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https://www.readbyqxmd.com/read/29765871/optimizing-medicine-use-for-people-who-are-homebound-an-evaluation-of-a-pilot-domiciliary-medicine-use-review-dmur-service-in-england
#1
Asam Latif, Baguiasri Mandane, Emma Anderson, Caroline Barraclough, Samantha Travis
Background: As global life expectancy increases, older people with chronic diseases are being required to manage multiple and complex medicine regimes. However, polypharmacy raises the risk of medicine-related problems and preventable hospital admissions. To improve medicine use, English community pharmacies are commissioned to deliver Medicines Use Reviews (MURs), which are typically delivered from the pharmacy. People who are homebound rarely receive the service. This paper describes the uptake and impact of a pilot project that seeks to provide domiciliary Medicines Use Reviews (dMURs)...
2018: Integrated Pharmacy Research and Practice
https://www.readbyqxmd.com/read/29671885/-i-expected-just-to-walk-in-get-my-tablets-and-then-walk-out-on-framing-new-community-pharmacy-services-in-the-english-healthcare-system
#2
Asam Latif, Justin Waring, Deborah Watmough, Matthew J Boyd, Rachel A Elliott
Reconfiguration of the healthcare division of labour is becoming increasingly attractive in the context of increased patient demand and resource constraints. One example is the introduction of extended roles for pharmacists to provide patients additional support to manage their medicines, while also reducing work pressures experienced by other health professionals. Understanding how such policies are framed by those delivering and receiving care has been under-theorised. Using Goffman's frame theory, we examine one newly introduced community pharmacy service (New Medicines Service (NMS)) to illustrate how a policy intended to support patient medicine-taking through the extended roles of pharmacists is framed and where this deviates from its proposed aims...
April 19, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29601307/applying-american-society-of-addiction-medicine-performance-measures-in-commercial-health-insurance-and-services-data
#3
Cindy Parks Thomas, Grant A Ritter, Alex H S Harris, Deborah W Garnick, Kenneth I Freedman, Barbara Herbert
OBJECTIVES: ASAM's Standards of Care for the Addiction Specialist established appropriate care for the treatment of substance use disorders. ASAM identified three high priority performance measures for specification and testing for feasibility in various systems using administrative claims: use of pharmacotherapy for alcohol use disorder (AUD); use of pharmacotherapy for opioid use disorder (OUD); and continuity of care after withdrawal management services. This study adds to the initial testing of these measures in the Veteran's Health Administration (VHA) by testing the feasibility of specifications in commercial insurance data (Cigna)...
March 29, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29569381/an-exploration-of-predictors-of-children-s-nurses-attitudes-knowledge-confidence-and-clinical-behavioural-intentions-towards-children-and-young-people-who-self-harm
#4
Tim Carter, Asam Latif, Patrick Callaghan, Joseph C Manning
AIMS AND OBJECTIVES: To explore the potential predictors of children's nurses' attitudes, knowledge and confidence towards caring for children and young people admitted to hospital with self-harm. BACKGROUND: Admissions to paediatric inpatient settings for individuals who have self-harmed are growing. Limited previous research suggests nurses have mixed attitudes towards people who have self-harmed, and potentially lack the confidence to provide effective care. There is a specific paucity of research in this area for children's nurses...
March 22, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29382062/giving-voice-to-the-medically-under-served-a-qualitative-co-production-approach-to-explore-patient-medicine-experiences-and-improve-services-to-marginalized-communities
#5
Asam Latif, Sana Tariq, Nasa Abbasi, Baguiasri Mandane
BACKGROUND: With an aging population, the appropriate, effective and safe use of medicines is a global health priority. However, "'medically under-served" patients continue to experience significant inequalities around access to healthcare services. AIM: This study forms part of a wider project to co-develop and evaluate a digital educational intervention for community pharmacy. The aim of this paper is to explore the medicine needs of patients from marginalized communities and suggest practical way on how services could be better tailored to their requirements...
January 27, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29192156/unbiased-quantitative-proteomics-reveals-a-crucial-role-of-the-allergen-context-for-the-activation-of-human-dendritic-cells
#6
L Strasser, H-H Dang, H Schwarz, C Asam, F Ferreira, J Horejs-Hoeck, C G Huber
Worldwide, more than 1 billion people suffer from allergic diseases. However, until now it is not fully understood how certain proteins can induce allergic immune responses, while others cannot. Studies suggest that allergenicity is a process not only determined by properties of the allergen itself but also by costimulatory factors, that are not classically associated with allergic reactions. To investigate the allergenicity of the major birch pollen allergen Bet v 1 and the impact of adjuvants associated with pollen, e...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29119822/co-producing-a-digital-educational-programme-for-registered-children-s-nurses-to-improve-care-of-children-and-young-people-admitted-with-self-harm
#7
Asam Latif, Timothy Carter, Lucy Rychwalska-Brown, Heather Wharrad, Joseph Manning
Despite the increasing prevalence of hospital admissions for self-harm in children and young people (CYP), there is paucity of registered children's nurse (rCN) training or involvement of children to improve care for this often stigmatized patient group. This article describes a participatory approach towards using co-production with CYP and rCN to develop a digital educational programme to improve nurses' knowledge, attitudes and confidence in caring for CYP with self-harm injuries. A priority-setting workshop with rCNs was used to establish consensus of information needs...
June 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29035299/two-distinct-conformations-in-bet-v-2-determine-its-proteolytic-resistance-to-cathepsin-s
#8
Wai Tuck Soh, Peter Briza, Elfriede Dall, Claudia Asam, Mario Schubert, Sara Huber, Lorenz Aglas, Barbara Bohle, Fatima Ferreira, Hans Brandstetter
Birch pollen allergy affects more than 20% of the European allergic population. On a molecular level, birch pollen allergy can be linked to the two dominant allergens Bet v 1 and Bet v 2. Bet v 2 belongs to the profilin family, which is abundant in the plant kingdom. Importantly, the homologous plant profilins have a conserved cysteine motif with a currently unknown functional relevance. In particular, it is unknown whether the motif is relevant for disulfide formation and to what extent it would affect the profilins' structural, functional and immunological properties...
October 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28974818/optimization-of-osmotic-dehydration-of-terung-asam-solanum-lasiocarpum-dunal
#9
Moi-Thin Chiu, Heng Jin Tham, Jau-Shya Lee
This study was designed to determine the effect of osmotic dehydration (OD) process temperature (35-55 °C), sucrose concentration (40-60% w/w) and immersion time (90-210 min) on the water loss (WL), solid gain (SG), DPPH radical scavenging activity, ferric reducing antioxidant power (FRAP) and sensory quality of the dehydrated Terung Asam slices. Response Surface Methodology with Central Composite Design was applied to investigate the influence of these variables on the aforementioned responses. The increase in the levels of these processing parameters increased the WL and SG...
September 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28922646/synthesis-spectral-characterization-and-computed-optical-analysis-of-potent-triazole-based-compounds
#10
Sajjad H Sumrra, Fazila Mushtaq, Muhammad Khalid, Muhammad Asam Raza, Muhammad Faizan Nazar, Bakhat Ali, Ataualpa A C Braga
Biologically active triazole Schiff base ligand (L) and metal complexes [Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)] are reported herein. The ligand acted as tridentate and coordinated towards metallic ions via azomethine-N, triazolic-N moiety and deprotonated-O of phenyl substituents in an octahedral manner. These compounds were characterized by physical, spectral and analytical analysis. The synthesized ligand and metal complexes were screened for antibacterial pathogens against Chromohalobacter salexigens, Chromohalobacter israelensi, Halomonas halofila and Halomonas salina, antifungal bioassay against Aspergillus niger and Aspergellus flavin, antioxidant (DPPH, phosphomolybdate) and also for enzyme inhibition [butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)] studies...
February 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28776320/cost-effectiveness-of-support-for-people-starting-a-new-medication-for-a-long-term-condition-through-community-pharmacies-an-economic-evaluation-of-the-new-medicine-service-nms-compared-with-normal-practice
#11
Rachel A Elliott, Lukasz Tanajewski, Georgios Gkountouras, Anthony J Avery, Nick Barber, Rajnikant Mehta, Matthew J Boyd, Asam Latif, Antony Chuter, Justin Waring
BACKGROUND: The English community pharmacy New Medicine Service (NMS) significantly increases patient adherence to medicines, compared with normal practice. We examined the cost effectiveness of NMS compared with normal practice by combining adherence improvement and intervention costs with the effect of increased adherence on patient outcomes and healthcare costs. METHODS: We developed Markov models for diseases targeted by the NMS (hypertension, type 2 diabetes mellitus, chronic obstructive pulmonary disease, asthma and antiplatelet regimens) to assess the impact of patients' non-adherence...
December 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28744179/determination-of-drought-tolerance-related-traits-in-helianthus-argophyllus-helianthus-annuus-and-their-hybrids
#12
Muhammad Mubashar Hussain, Saeed Rauf, Muhammad Asam Riaz, Jameel Muhammad Al-Khayri, Philippe Monneveux
Drought is a major constraint for sunflower (Helianthus annuus) production worldwide. Drought tolerance traits have been identified in the related wild species Helianthus argophyllus. This study was initiated to develop sunflower drought-tolerant genotypes by crossing cultivated sunflower with this species and analyze drought tolerance traits in the H. annuus and H. argophyllus populations, H. annuus intraspecific hybrids, and H. annuus × H. argophyllus interspecific hybrids along with the commercial hybrid Hysun-33 under three stress regimes: exogenous application of ABA, both by foliar spray and irrigation, and 5% PEG-induced osmotic stress...
June 2017: Breeding Science
https://www.readbyqxmd.com/read/28729676/proteomic-profiling-of-the-weed-feverfew-a-neglected-pollen-allergen-source
#13
Isabel Pablos, Stephanie Eichhorn, Peter Briza, Claudia Asam, Ulrike Gartner, Martin Wolf, Christof Ebner, Barbara Bohle, Naveen Arora, Stefan Vieths, Fatima Ferreira, Gabriele Gadermaier
Feverfew (Parthenium hysterophorus), an invasive weed from the Asteraceae family, has been reported as allergen source. Despite its relevance, knowledge of allergens is restricted to a partial sequence of a hydroxyproline-rich glycoprotein. We aimed to obtain the entire sequence for recombinant production and characterize feverfew pollen using proteomics and immunological assays. Par h 1, a defensin-proline fusion allergen was obtained by cDNA cloning and recombinantly produced in E. coli. Using two complementary proteomic strategies, a total of 258 proteins were identified in feverfew pollen among those 47 proteins belonging to allergenic families...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28648623/isolation-of-anticancer-and-antimicrobial-metabolites-from-epicoccum-nigrum-endophyte-of-ferula-sumbul
#14
Irum Perveen, Muhammad Asam Raza, Tahir Iqbal, Iffat Naz, Shama Sehar, Safia Ahmed
Owing to the importance of endophytes, current research was aimed to purify the secondary metabolites from targeted source. Ferula sumbul, a lipophilic extract of the endophyte was prepared in 10% methanol and partitioned with ethyl acetate and bioassay guided isolation was carried using standard protocols against bacterial, fungal and cancer cells. The active fractions consisted of three new metabolites (2-methyl-3-nonyl prodiginine, Bis (2-ethylhexyl) phthalate, and a meroterpenoid, Preaustinoid A). Their structures were confirmed with LCMS/MS...
June 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28594355/comparing-proteolytic-fingerprints-of-antigen-presenting-cells-during-allergen-processing
#15
Heidi Hofer, Tamara Weidinger, Peter Briza, Claudia Asam, Martin Wolf, Teresa E Twaroch, Frank Stolz, Angela Neubauer, Elfriede Dall, Peter Hammerl, Alain Jacquet, Michael Wallner
Endolysosomal processing has a critical influence on immunogenicity as well as immune polarization of protein antigens. In industrialized countries, allergies affect around 25% of the population. For the rational design of protein-based allergy therapeutics for immunotherapy, a good knowledge of T cell-reactive regions on allergens is required. Thus, we sought to analyze endolysosomal degradation patterns of inhalant allergens. Four major allergens from ragweed, birch, as well as house dust mites were produced as recombinant proteins...
June 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28494467/expression-and-characterization-of-functional-recombinant-bet-v-1-0101-in-the-chloroplast-of-chlamydomonas-reinhardtii
#16
Sonja Hirschl, Claudia Ralser, Claudia Asam, Alessandro Gangitano, Sara Huber, Christof Ebner, Barbara Bohle, Martin Wolf, Peter Briza, Fatima Ferreira, Christoph Griesbeck, Michael Wallner
BACKGROUND: Allergen immunotherapy (AIT) still plays a minor role in the treatment of allergic diseases. To improve the acceptance of AIT by allergic patients, the treatment has to become more convenient and efficacious. One possibility is the oral application of allergens or derivatives thereof. Therefore, we sought to produce a recombinant allergen in the green alga Chlamydomonas reinhardtii as a novel production platform. METHODS: The major birch pollen allergen Bet v 1 was selected as candidate molecule, and a codon-optimized gene was synthesized and stably integrated into the microalga C...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28473515/-our-care-through-our-eyes-impact-of-a-co-produced-digital-educational-programme-on-nurses-knowledge-confidence-and-attitudes-in-providing-care-for-children-and-young-people-who-have-self-harmed-a-mixed-methods-study-in-the-uk
#17
Joseph C Manning, Tim Carter, Asam Latif, Angela Horsley, Joanne Cooper, Marie Armstrong, Jamie Crew, Damian Wood, Patrick Callaghan, Heather Wharrad
OBJECTIVES: (1) To determine the impact of a digital educational intervention on the knowledge, attitudes, confidence and behavioural intention of registered children's nurses working with children and young people (CYP) admitted with self-harm.(2) To explore the perceived impact, suitability and usefulness of the intervention. INTERVENTION: A digital educational intervention that had been co-produced with CYP service users, registered children's nurses and academics...
May 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28464293/amb-a-1-isoforms-unequal-siblings-with-distinct-immunological-features
#18
M Wolf, T E Twaroch, S Huber, M Reithofer, M Steiner, L Aglas, M Hauser, I Aloisi, C Asam, H Hofer, M A Parigiani, C Ebner, B Bohle, P Briza, A Neubauer, F Stolz, B Jahn-Schmid, M Wallner, F Ferreira
BACKGROUND: Ragweed pollen represents a major allergy risk factor. Ragweed extracts contain five different isoforms of the major allergen Amb a 1. However, the immunological characteristics of Amb a 1 isoforms are not fully investigated. Here, we compared the physicochemical and immunological properties of three most important Amb a 1 isoforms. METHODS: After purification, the isoforms were physicochemically characterized, tested for antibody binding and induction of human T-cell proliferative responses...
December 2017: Allergy
https://www.readbyqxmd.com/read/28456805/allergens-of-blomia-tropicalis-an-overview-of-recombinant-molecules
#19
REVIEW
Eduardo Santos da Silva, Claudia Asam, Peter Lackner, Heidi Hofer, Michael Wallner, Carina Silva Pinheiro, Neuza Maria Alcântara-Neves, Fatima Ferreira
Allergic diseases are considered a major problem for healthcare systems in both developed and developing countries. House dust mites are well-known triggers of allergic manifestations. While the Dermatophagoides genus is widely distributed globally, Blomia tropicalis is the most prominent mite species in the tropical and subtropical regions of the world. Over the last decades, an increase in sensitization rates to B. tropicalis has been reported, leading to increased research efforts on Blomia allergens. In fact, 8 new allergens have been identified and characterized to different degrees...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28151491/clinical-and-molecular-consequences-of-disease-associated-de-novo-mutations-in-satb2
#20
Hemant Bengani, Mark Handley, Mohsan Alvi, Rita Ibitoye, Melissa Lees, Sally Ann Lynch, Wayne Lam, Madeleine Fannemel, Ann Nordgren, H Malmgren, M Kvarnung, Sarju Mehta, Shane McKee, Margo Whiteford, Fiona Stewart, Fiona Connell, Jill Clayton-Smith, Sahar Mansour, Shehla Mohammed, Alan Fryer, Jenny Morton, Detelina Grozeva, Tara Asam, David Moore, Alejandro Sifrim, Jeremy McRae, Matthew E Hurles, Helen V Firth, F Lucy Raymond, Usha Kini, Christoffer Nellåker, Ddd Study, David R FitzPatrick
PURPOSE: To characterize features associated with de novo mutations affecting SATB2 function in individuals ascertained on the basis of intellectual disability. METHODS: Twenty previously unreported individuals with 19 different SATB2 mutations (11 loss-of-function and 8 missense variants) were studied. Fibroblasts were used to measure mutant protein production. Subcellular localization and mobility of wild-type and mutant SATB2 were assessed using fluorescently tagged protein...
August 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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