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Petra Bacher, Frederik Heinrich, Ulrik Stervbo, Mikalai Nienen, Marco Vahldieck, Christina Iwert, Katrin Vogt, Jutta Kollet, Nina Babel, Birgit Sawitzki, Carsten Schwarz, Stefan Bereswill, Markus M Heimesaat, Guido Heine, Gabriele Gadermaier, Claudia Asam, Mario Assenmacher, Olaf Kniemeyer, Axel A Brakhage, Fátima Ferreira, Michael Wallner, Margitta Worm, Alexander Scheffold
FOXP3+ regulatory T cells (Tregs) maintain tolerance against self-antigens and innocuous environmental antigens. However, it is still unknown whether Treg-mediated tolerance is antigen specific and how Treg specificity contributes to the selective loss of tolerance, as observed in human immunopathologies such as allergies. Here, we used antigen-reactive T cell enrichment to identify antigen-specific human Tregs. We demonstrate dominant Treg-mediated tolerance against particulate aeroallergens, such as pollen, house dust mites, and fungal spores...
October 18, 2016: Cell
Alemayehu Desalegn, Asamer Tsegaw, Destaye Shiferaw, Haile Woretaw
BACKGROUND: Refractive error is the main cause of visual impairment in the world. Spectacles are the most frequently used options for correcting refractive errors. In addition, they can be used for protection and fashion. It is the simplest, cheapest and only method used in developing countries like Ethiopia. This study aims to explore the knowledge, attitude, practice and associated factors towards spectacles use among adult population of Gondar town, northwest Ethiopia. METHODS: Community based cross sectional study was conducted on 780 participants using a pre-tested structured questionnaire in Gondar...
October 21, 2016: BMC Ophthalmology
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Journal of Addiction Medicine
(no author information available yet)
No abstract text is available yet for this article.
July 2016: Journal of Addiction Medicine
Jill M Williams, Marc L Steinberg, Alexandra N Kenefake, Michael V Burke
Tobacco use is a major threat to public health in the United States, and the number one cause of preventable death. Although most smokers try to quit unaided, robust data indicate that pairing behavioral support to US Food Drug Administration-approved cessation medications significantly increase cessation rates. Those who do receive assistance in quitting usually receive very low intensity treatment, regardless of the severity of their dependence or their medical and environmental circumstances. This is in stark contrast to how other substance use disorders are treated, where there are varying levels of care depending on addiction severity and biopsychosocial circumstances...
September 2016: Journal of Addiction Medicine
Kenneth Blum, Mark Gold, H Westley Clark, Kristina Dushaj, Rajendra D Badgaiyan
Attention must be focused on needed changes to the current United States law that restricts physicians who prescribe buprenorphine for the detoxification or treatment of Opioid Use Disorder, to accepting no more than 100 patients. The current system does not provide comprehensive treatment as defined by the American Society of Addiction Medicine (ASAM) criteria. In addition, it suffers from both fragmentation and stigma and will require a significant change to comply with ASAM's call for integrated delivery of comprehensive addiction treatment...
October 14, 2016: Substance Use & Misuse
Hatem Ali, Asam Murtaza, John Anderton, Aimun Ahmed
[This corrects the article DOI: 10.1186/s40064-015-1292-0.].
2016: SpringerPlus
Asam Murtaza, Hatem Ali, Beena Nair, Aimun K Ahmed
We report a case of recurrent tubulointerstitial nephritis without uveitis in a patient with previous tubulointerstitial nephritis and uveitis syndrome after transplant. A 26-year-old male patient who had been diagnosed with tubulointerstitial nephritis and uveitis syndrome at 8 years of age developed end-stage renal failure and subsequently underwent living-donor related renal transplant at 17 years old. The 1st recurrence of tubulointerstitial nephritis and uveitis occurred 36 months after transplant, which was treated with increased immunosuppressive drugs...
June 29, 2016: Experimental and Clinical Transplantation
(no author information available yet)
No abstract text is available yet for this article.
May 2016: Journal of Addiction Medicine
Jeroen Walravens, Hannes Mikula, Michael Rychlik, Stefan Asam, Tom Devos, Emmanuel Njumbe Ediage, José Diana Di Mavungu, Liesbeth Jacxsens, Anita Van Landschoot, Lynn Vanhaecke, Sarah De Saeger
Ultraperformance liquid chromatography tandem mass spectrometry and Quick, Easy, Cheap, Effective, Rugged, and Safe based analytical methodologies to quantitate both free (alternariol (1), alternariol monomethyl ether (2), tenuazonic acid (3), tentoxin (4), altenuene (5), altertoxin-I (6)) and conjugated (sulfates and glucosides of 1 and 2) Alternaria toxins in fruit and vegetable juices and tomato products were developed and validated. Acceptable limits of quantitation (0.7-5.7 μg/kg), repeatability (RSDr < 15...
June 22, 2016: Journal of Agricultural and Food Chemistry
Olivia E McKenna, Claudia Asam, Galber R Araujo, Anargyros Roulias, Luiz R Goulart, Fatima Ferreira
Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross-reactivity between related and unrelated allergenic sources. Such cross-reactivities include reactions between various pollen sources, pollen and plant-derived foods as well as invertebrate-derived inhalants and foodstuff. Here, we provide an overview on the most clinically relevant panallergens from plants (profilins, polcalcins, non-specific lipid transfer proteins, pathogenesis-related protein family 10 members) and on the prominent animal-derived panallergen family, tropomyosins...
September 2016: Pediatric Allergy and Immunology
Muhammad Asam Raza, Farwa Anwar, Durre Shahwar, Abdul Majeed, Muhammad Waseem Mumtaz, Muhammad Danish, Muhammad Faizan Nazar, Irum Perveen, Salah Ud-Din Khan
The current study was designed to check the antioxidant and enzyme inhibition potential of various extracts/ fractions of three selected plants. The aerial parts of Conocarpus erectus (Combretaceae), Ficus variegata (Moraceae) and Ficus maclellandii (Moraceae) were extracted with ethanol (95%) and the resulting crude extracts were partitioned with n-hexane, chloroform and n-butanol successively. Folin-Ciocalteu reagent was used to calculate the total phenolic contents, flavonoids contents were calculated with aluminum chloride while antioxidant and enzyme studies were carried out through standard protocols...
March 2016: Pakistan Journal of Pharmaceutical Sciences
Isabel Pablos, Sabrina Wildner, Claudia Asam, Michael Wallner, Gabriele Gadermaier
Pollen allergens are one of the main causes of type I allergies affecting up to 30% of the population in industrialized countries. Climatic changes affect the duration and intensity of pollen seasons and may together with pollution contribute to increased incidences of respiratory allergy and asthma. Allergenic grasses, trees, and weeds often present similar habitats and flowering periods compromising clinical anamnesis. Molecule-based approaches enable distinction between genuine sensitization and clinically mostly irrelevant IgE cross-reactivity due to, e...
April 2016: Current Allergy and Asthma Reports
(no author information available yet)
No abstract text is available yet for this article.
March 2016: Journal of Addiction Medicine
Alex H S Harris, Constance M Weisner, Mady Chalk, Victor Capoccia, Cheng Chen, Cindy Parks Thomas
OBJECTIVES: In 2013, the American Society of Addiction Medicine (ASAM) approved its Standards of Care for the Addiction Specialist Physician. Subsequently, an ASAM Performance Measures Panel identified and prioritized the standards to be operationalized into performance measures. The goal of this study is to describe the process of operationalizing 3 of these standards into quality measures, and to present the initial measure specifications and results of pilot testing these measures in a large health care system...
May 2016: Journal of Addiction Medicine
Asam Latif, Justin Waring, Deborah Watmough, Nick Barber, Anthony Chuter, James Davies, Nde-Eshimuni Salema, Matthew J Boyd, Rachel A Elliott
BACKGROUND: Community pharmacies are increasingly commissioned to deliver new, complex health interventions in response to the growing demands on family doctors and secondary health care services. Little is known about how these complex interventions are being accommodated and translated into the community pharmacy setting and whether their aims and objectives are realized in practice. The New Medicine Service (NMS) is a complex medicine management intervention that aims to support patients' adherence to newly prescribed medicines for a long-term condition...
December 29, 2015: Research in Social & Administrative Pharmacy: RSAP
Justin Waring, Asam Latif, Matthew Boyd, Nick Barber, Rachel Elliott
Community pharmacists play a growing role in the delivery of primary healthcare. This has led many to consider the changing power of the pharmacy profession in relation to other professions and patient groups. This paper contributes to these debates through developing a Foucauldian analysis of the changing dynamics of power brought about by extended roles in medicines management and patient education. Examining the New Medicine Service, the study considers how both patient and pharmacist subjectivities are transformed as pharmacists seek to survey patient's medicine use, diagnose non-adherence to prescribed medicines, and provide education to promote behaviour change...
January 2016: Social Science & Medicine
Nurhanani Razali, Sarni Mat Junit, Azhar Ariffin, Nur Siti Fatimah Ramli, Azlina Abdul Aziz
BACKGROUND: Tamarindus indica L. (T. indica) or locally known as "asam jawa" belongs to the family Leguminosae. T. indica seeds as by-products from the fruits were previously reported to contain high polyphenolic content. However, identification of their bioactive polyphenols using recent technologies is less well researched but nonetheless important. Hence, it was the aim of this study to provide further information on the polyphenolic content and antioxidant activities as well as to identify and quantify its bioactive polyphenols...
2015: BMC Complementary and Alternative Medicine
Stephanie L Mayne, Brian K Lee, Amy H Auchincloss
BACKGROUND: Quasi-experimental studies of menu labeling have found mixed results for improving diet. Differences between experimental groups can hinder interpretation. Propensity scores are an increasingly common method to improve covariate balance, but multiple methods exist and the improvements associated with each method have rarely been compared. In this re-analysis of the impact of menu labeling, we compare multiple propensity score methods to determine which methods optimize balance between experimental groups...
2015: PloS One
Rachel Ann Elliott, Matthew J Boyd, Nde-Eshimuni Salema, James Davies, Nicholas Barber, Rajnikant Laxmishanker Mehta, Lukasz Tanajewski, Justin Waring, Asam Latif, Georgios Gkountouras, A J Avery, Antony Chuter, Christopher Craig
OBJECTIVE: To examine the effectiveness of the New Medicine Service (NMS), a national community pharmacy service to support medicines-taking in people starting a new medicine for a long-term condition, compared with normal practice. METHODS: Pragmatic patient-level parallel randomised controlled trial, in 46 community pharmacies in England. Patients 1:1 block randomisation stratified by drug/disease group within each pharmacy. 504 participants (NMS: 251) aged 14 years and over, identified in the pharmacy on presentation of a prescription for asthma/chronic obstructive pulmonary disease, hypertension, type 2 diabetes or an anticoagulant/antiplatelet agent...
October 2016: BMJ Quality & Safety
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