keyword
MENU ▼
Read by QxMD icon Read
search

ASAM

keyword
https://www.readbyqxmd.com/read/28494467/expression-and-characterization-of-functional-recombinant-bet-v-1-0101-in-the-chloroplast-of-chlamydomonas-reinhardtii
#1
Sonja Hirschl, Claudia Ralser, Claudia Asam, Alessandro Gangitano, Sara Huber, Christof Ebner, Barbara Bohle, Martin Wolf, Peter Briza, Fatima Ferreira, Christoph Griesbeck, Michael Wallner
BACKGROUND: Allergen immunotherapy (AIT) still plays a minor role in the treatment of allergic diseases. To improve the acceptance of AIT by allergic patients, the treatment has to become more convenient and efficacious. One possibility is the oral application of allergens or derivatives thereof. Therefore, we sought to produce a recombinant allergen in the green alga Chlamydomonas reinhardtii as a novel production platform. METHODS: The major birch pollen allergen Bet v 1 was selected as candidate molecule, and a codon-optimized gene was synthesized and stably integrated into the microalga C...
May 12, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28473515/-our-care-through-our-eyes-impact-of-a-co-produced-digital-educational-programme-on-nurses-knowledge-confidence-and-attitudes-in-providing-care-for-children-and-young-people-who-have-self-harmed-a-mixed-methods-study-in-the-uk
#2
Joseph C Manning, Tim Carter, Asam Latif, Angela Horsley, Joanne Cooper, Marie Armstrong, Jamie Crew, Damian Wood, Patrick Callaghan, Heather Wharrad
OBJECTIVES: (1) To determine the impact of a digital educational intervention on the knowledge, attitudes, confidence and behavioural intention of registered children's nurses working with children and young people (CYP) admitted with self-harm.(2) To explore the perceived impact, suitability and usefulness of the intervention. INTERVENTION: A digital educational intervention that had been co-produced with CYP service users, registered children's nurses and academics...
May 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28464293/amb-a-1-isoforms-unequal-siblings-with-distinct-immunological-features
#3
Martin Wolf, Teresa E Twaroch, Sara Huber, Manuel Reithofer, Markus Steiner, Lorenz Aglas, Michael Hauser, Iris Aloisi, Claudia Asam, Heidi Hofer, Maria A Parigiani, Christof Ebner, Barbara Bohle, Peter Briza, Neubauer Angela, Frank Stolz, Beatrice Jahn-Schmid, Michael Wallner, Fatima Ferreira
BACKGROUND: Ragweed pollen represents a major allergy risk factor. Ragweed extracts contain five different isoforms of the major allergen Amb a 1. However, the immunologic characteristics of Amb a 1 isoforms are not fully investigated. Here we compared the physicochemical and immunological properties of three most important Amb a 1 isoforms. METHODS: After purification, the isoforms were physicochemically characterized, tested for antibody-binding and induction of human T cell proliferative responses...
May 2, 2017: Allergy
https://www.readbyqxmd.com/read/28456805/allergens-of-blomia-tropicalis-an-overview-of-recombinant-molecules
#4
Eduardo Santos da Silva, Claudia Asam, Peter Lackner, Heidi Hofer, Michael Wallner, Carina Silva Pinheiro, Neuza Maria Alcântara-Neves, Fatima Ferreira
Allergic diseases are considered a major problem for healthcare systems in both developed and developing countries. House dust mites are well-known triggers of allergic manifestations. While the Dermatophagoides genus is widely distributed globally, Blomia tropicalis is the most prominent mite species in the tropical and subtropical regions of the world. Over the last decades, an increase in sensitization rates to B. tropicalis has been reported, leading to increased research efforts on Blomia allergens. In fact, 8 new allergens have been identified and characterized to different degrees...
April 29, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28151491/clinical-and-molecular-consequences-of-disease-associated-de-novo-mutations-in-satb2
#5
Hemant Bengani, Mark Handley, Mohsan Alvi, Rita Ibitoye, Melissa Lees, Sally Ann Lynch, Wayne Lam, Madeleine Fannemel, Ann Nordgren, H Malmgren, M Kvarnung, Sarju Mehta, Shane McKee, Margo Whiteford, Fiona Stewart, Fiona Connell, Jill Clayton-Smith, Sahar Mansour, Shehla Mohammed, Alan Fryer, Jenny Morton, Detelina Grozeva, Tara Asam, David Moore, Alejandro Sifrim, Jeremy McRae, Matthew E Hurles, Helen V Firth, F Lucy Raymond, Usha Kini, Christoffer Nellåker, Ddd Study, David R FitzPatrick
PURPOSE: To characterize features associated with de novo mutations affecting SATB2 function in individuals ascertained on the basis of intellectual disability. METHODS: Twenty previously unreported individuals with 19 different SATB2 mutations (11 loss-of-function and 8 missense variants) were studied. Fibroblasts were used to measure mutant protein production. Subcellular localization and mobility of wild-type and mutant SATB2 were assessed using fluorescently tagged protein...
February 2, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28081194/t-cell-epitope-containing-domains-of-ragweed-amb-a-1-and-mugwort-art-v-6-modulate-immunologic-responses-in-humans-and-mice
#6
Ana I Sancho, Michael Wallner, Michael Hauser, Birgit Nagl, Martin Himly, Claudia Asam, Christof Ebner, Beatrice Jahn-Schmid, Barbara Bohle, Fatima Ferreira
BACKGROUND: Ragweed (Ambrosia artemisiifolia) and mugwort (Artemisia vulgaris) are the major cause of pollen allergy in late summer. Allergen-specific lymphocytes are crucial for immune modulation during immunotherapy. We sought to generate and pre-clinically characterise highly immunogenic domains of the homologous pectate lyases in ragweed (Amb a 1) and mugwort pollen (Art v 6) for immunotherapy. METHODS: Domains of Amb a 1 (Amb a 1α) and Art v 6 (Art v 6α) and a hybrid molecule, consisting of both domains, were designed, expressed in E...
2017: PloS One
https://www.readbyqxmd.com/read/28004997/effect-of-long-term-low-dose-aspirin-therapy-on-renal-graft-function
#7
Hatem Ali, Ahmed Shaaban, Asam Murtaza, Laura E Howell, Aimun Ahmed
OBJECTIVES: Despite improvements in immunosuppressive protocols for renal transplant, long-term success of renal transplant is still limited by the occurrence of interstitial fibrosis and tubular atrophy. Some studies have shown that aspirin decreases the severity of kidney ischemia-reperfusion injury and the development of tubular atrophy in animal models. This study aimed to assess the effects of aspirin therapy started at the time of transplant on long-term graft function. MATERIALS AND METHODS: We compared renal graft function of 82 patients on low-dose aspirin 75 mg once daily who underwent renal transplant between 1 January 2000 and 31 December 2010 from a single center with 65 patients not taking aspirin...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27957687/evaluation-of-an-enzyme-immunoassay-for-the-detection-of-the-mycotoxin-tenuazonic-acid-in-sorghum-grains-and-sorghum-based-infant-food
#8
Madeleine Gross, Stefan Asam, Michael Rychlik
An enzyme-linked immunosorbent assay (ELISA) for the Alternaria mycotoxin tenuazonic acid (TeA) was evaluated by comparative analysis of naturally contaminated sorghum grains and sorghum-based infant food, using a stable isotope dilution LC-MS assay (SIDA; limit of detection (LOD) 1.0 μg/kg) as the reference method. LODs of the ELISA were 30 μg/kg in sorghum grains and 220 μg/kg in sorghum-based infant cereals. With SIDA, 100% of the samples (n = 28) had been positive for TeA in a concentration range of 6-584 μg/kg (mean 113 μg/kg)...
February 2017: Mycotoxin Research
https://www.readbyqxmd.com/read/27940633/supporting-underserved-patients-with-their-medicines-a-study-protocol-for-a-patient-professional-coproduced-education-intervention-for-community-pharmacy-staff-to-improve-the-provision-and-delivery-of-medicine-use-reviews-murs
#9
Asam Latif, Kristian Pollock, Claire Anderson, Justin Waring, Josie Solomon, Li-Chia Chen, Emma Anderson, Sulma Gulzar, Nasa Abbasi, Heather Wharrad
INTRODUCTION: Community pharmacy increasingly features in global strategies to modernise the delivery of primary healthcare. Medicine Use Reviews (MURs) form part of the English Government's medicines management strategy to improve adherence and reduce medicine waste. MURs provide space for patient-pharmacist dialogue to discuss the well-known problems patients experience with medicine taking. However, 'underserved' communities (eg, black and minority ethnic communities, people with mental illness), who may benefit the most, may not receive this support...
December 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/27939703/tackling-bet-v-1-and-associated-food-allergies-with-a-single-hybrid-protein
#10
Heidi Hofer, Claudia Asam, Michael Hauser, Birgit Nagl, Josef Laimer, Martin Himly, Peter Briza, Christof Ebner, Roland Lang, Thomas Hawranek, Barbara Bohle, Peter Lackner, Fátima Ferreira, Michael Wallner
BACKGROUND: Allergy vaccines should be easily applicable, safe, and efficacious. For Bet v 1-mediated birch pollen and associated food allergies, a single wild-type allergen does not provide a complete solution. OBJECTIVE: We aimed to combine immunologically relevant epitopes of Bet v 1 and the 2 clinically most important related food allergens from apple and hazelnut to a single hybrid protein, termed MBC4. METHODS: After identification of T cell epitope-containing parts on each of the 3 parental allergens, the hybrid molecule was designed to cover relevant epitopes and evaluated in silico...
December 7, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27773482/regulatory-t-cell-specificity-directs-tolerance-versus-allergy-against-aeroantigens-in-humans
#11
Petra Bacher, Frederik Heinrich, Ulrik Stervbo, Mikalai Nienen, Marco Vahldieck, Christina Iwert, Katrin Vogt, Jutta Kollet, Nina Babel, Birgit Sawitzki, Carsten Schwarz, Stefan Bereswill, Markus M Heimesaat, Guido Heine, Gabriele Gadermaier, Claudia Asam, Mario Assenmacher, Olaf Kniemeyer, Axel A Brakhage, Fátima Ferreira, Michael Wallner, Margitta Worm, Alexander Scheffold
FOXP3+ regulatory T cells (Tregs) maintain tolerance against self-antigens and innocuous environmental antigens. However, it is still unknown whether Treg-mediated tolerance is antigen specific and how Treg specificity contributes to the selective loss of tolerance, as observed in human immunopathologies such as allergies. Here, we used antigen-reactive T cell enrichment to identify antigen-specific human Tregs. We demonstrate dominant Treg-mediated tolerance against particulate aeroallergens, such as pollen, house dust mites, and fungal spores...
November 3, 2016: Cell
https://www.readbyqxmd.com/read/27769198/knowledge-attitude-practice-and-associated-factors-towards-spectacles-use-among-adults-in-gondar-town-northwest-ethiopia
#12
Alemayehu Desalegn, Asamer Tsegaw, Destaye Shiferaw, Haile Woretaw
BACKGROUND: Refractive error is the main cause of visual impairment in the world. Spectacles are the most frequently used options for correcting refractive errors. In addition, they can be used for protection and fashion. It is the simplest, cheapest and only method used in developing countries like Ethiopia. This study aims to explore the knowledge, attitude, practice and associated factors towards spectacles use among adult population of Gondar town, northwest Ethiopia. METHODS: Community based cross sectional study was conducted on 780 participants using a pre-tested structured questionnaire in Gondar...
October 21, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27685684/society-news-asam-magazine
#13
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27471924/society-news-asam-magazine
#14
(no author information available yet)
No abstract text is available yet for this article.
July 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27466070/an-argument-for-change-in-tobacco-treatment-options-guided-by-the-asam-criteria-for-patient-placement
#15
Jill M Williams, Marc L Steinberg, Alexandra N Kenefake, Michael V Burke
Tobacco use is a major threat to public health in the United States, and the number one cause of preventable death. Although most smokers try to quit unaided, robust data indicate that pairing behavioral support to US Food Drug Administration-approved cessation medications significantly increase cessation rates. Those who do receive assistance in quitting usually receive very low intensity treatment, regardless of the severity of their dependence or their medical and environmental circumstances. This is in stark contrast to how other substance use disorders are treated, where there are varying levels of care depending on addiction severity and biopsychosocial circumstances...
September 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27462930/should-the-united-states-government-repeal-restrictions-on-buprenorphine-naloxone-treatment
#16
Kenneth Blum, Mark Gold, H Westley Clark, Kristina Dushaj, Rajendra D Badgaiyan
Attention must be focused on needed changes to the current United States law that restricts physicians who prescribe buprenorphine for the detoxification or treatment of Opioid Use Disorder, to accepting no more than 100 patients. The current system does not provide comprehensive treatment as defined by the American Society of Addiction Medicine (ASAM) criteria. In addition, it suffers from both fragmentation and stigma and will require a significant change to comply with ASAM's call for integrated delivery of comprehensive addiction treatment...
October 14, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/27429873/erratum-to-post-renal-biopsy-complication-rate-and-diagnostic-yield-comparing-hands-free-ultrasound-assisted-and-ultrasound-guided-biopsy-techniques-of-renal-allografts-and-native-kidneys
#17
Hatem Ali, Asam Murtaza, John Anderton, Aimun Ahmed
[This corrects the article DOI: 10.1186/s40064-015-1292-0.].
2016: SpringerPlus
https://www.readbyqxmd.com/read/27364115/recurrence-of-tubulointerstitial-nephritis-without-uveitis-in-a-patient-with-previous-tubulointerstitial-nephritis-and-uveitis-syndrome-after-transplant
#18
Asam Murtaza, Hatem Ali, Beena Nair, Aimun K Ahmed
We report a case of recurrent tubulointerstitial nephritis without uveitis in a patient with previous tubulointerstitial nephritis and uveitis syndrome after transplant. A 26-year-old male patient who had been diagnosed with tubulointerstitial nephritis and uveitis syndrome at 8 years of age developed end-stage renal failure and subsequently underwent living-donor related renal transplant at 17 years old. The 1st recurrence of tubulointerstitial nephritis and uveitis occurred 36 months after transplant, which was treated with increased immunosuppressive drugs...
June 29, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27223839/society-news-asam-magazine
#19
(no author information available yet)
No abstract text is available yet for this article.
May 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27180605/validated-uplc-ms-ms-methods-to-quantitate-free-and-conjugated-alternaria-toxins-in-commercially-available-tomato-products-and-fruit-and-vegetable-juices-in-belgium
#20
Jeroen Walravens, Hannes Mikula, Michael Rychlik, Stefan Asam, Tom Devos, Emmanuel Njumbe Ediage, José Diana Di Mavungu, Liesbeth Jacxsens, Anita Van Landschoot, Lynn Vanhaecke, Sarah De Saeger
Ultraperformance liquid chromatography tandem mass spectrometry and Quick, Easy, Cheap, Effective, Rugged, and Safe based analytical methodologies to quantitate both free (alternariol (1), alternariol monomethyl ether (2), tenuazonic acid (3), tentoxin (4), altenuene (5), altertoxin-I (6)) and conjugated (sulfates and glucosides of 1 and 2) Alternaria toxins in fruit and vegetable juices and tomato products were developed and validated. Acceptable limits of quantitation (0.7-5.7 μg/kg), repeatability (RSDr < 15...
June 22, 2016: Journal of Agricultural and Food Chemistry
keyword
keyword
33049
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"