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https://www.readbyqxmd.com/read/28081194/t-cell-epitope-containing-domains-of-ragweed-amb-a-1-and-mugwort-art-v-6-modulate-immunologic-responses-in-humans-and-mice
#1
Ana I Sancho, Michael Wallner, Michael Hauser, Birgit Nagl, Martin Himly, Claudia Asam, Christof Ebner, Beatrice Jahn-Schmid, Barbara Bohle, Fatima Ferreira
BACKGROUND: Ragweed (Ambrosia artemisiifolia) and mugwort (Artemisia vulgaris) are the major cause of pollen allergy in late summer. Allergen-specific lymphocytes are crucial for immune modulation during immunotherapy. We sought to generate and pre-clinically characterise highly immunogenic domains of the homologous pectate lyases in ragweed (Amb a 1) and mugwort pollen (Art v 6) for immunotherapy. METHODS: Domains of Amb a 1 (Amb a 1α) and Art v 6 (Art v 6α) and a hybrid molecule, consisting of both domains, were designed, expressed in E...
2017: PloS One
https://www.readbyqxmd.com/read/28004997/effect-of-long-term-low-dose-aspirin-therapy-on-renal-graft-function
#2
Hatem Ali, Ahmed Shaaban, Asam Murtaza, Laura E Howell, Aimun Ahmed
OBJECTIVES: Despite improvements in immunosuppressive protocols for renal transplant, long-term success of renal transplant is still limited by the occurrence of interstitial fibrosis and tubular atrophy. Some studies have shown that aspirin decreases the severity of kidney ischemia-reperfusion injury and the development of tubular atrophy in animal models. This study aimed to assess the effects of aspirin therapy started at the time of transplant on long-term graft function. MATERIALS AND METHODS: We compared renal graft function of 82 patients on low-dose aspirin 75 mg once daily who underwent renal transplant between 1 January 2000 and 31 December 2010 from a single center with 65 patients not taking aspirin...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27957687/evaluation-of-an-enzyme-immunoassay-for-the-detection-of-the-mycotoxin-tenuazonic-acid-in-sorghum-grains-and-sorghum-based-infant-food
#3
Madeleine Gross, Stefan Asam, Michael Rychlik
An enzyme-linked immunosorbent assay (ELISA) for the Alternaria mycotoxin tenuazonic acid (TeA) was evaluated by comparative analysis of naturally contaminated sorghum grains and sorghum-based infant food, using a stable isotope dilution LC-MS assay (SIDA; limit of detection (LOD) 1.0 μg/kg) as the reference method. LODs of the ELISA were 30 μg/kg in sorghum grains and 220 μg/kg in sorghum-based infant cereals. With SIDA, 100% of the samples (n = 28) had been positive for TeA in a concentration range of 6-584 μg/kg (mean 113 μg/kg)...
December 12, 2016: Mycotoxin Research
https://www.readbyqxmd.com/read/27940633/supporting-underserved-patients-with-their-medicines-a-study-protocol-for-a-patient-professional-coproduced-education-intervention-for-community-pharmacy-staff-to-improve-the-provision-and-delivery-of-medicine-use-reviews-murs
#4
Asam Latif, Kristian Pollock, Claire Anderson, Justin Waring, Josie Solomon, Li-Chia Chen, Emma Anderson, Sulma Gulzar, Nasa Abbasi, Heather Wharrad
INTRODUCTION: Community pharmacy increasingly features in global strategies to modernise the delivery of primary healthcare. Medicine Use Reviews (MURs) form part of the English Government's medicines management strategy to improve adherence and reduce medicine waste. MURs provide space for patient-pharmacist dialogue to discuss the well-known problems patients experience with medicine taking. However, 'underserved' communities (eg, black and minority ethnic communities, people with mental illness), who may benefit the most, may not receive this support...
December 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/27939703/tackling-bet-v-1-and-associated-food-allergies-with-a-single-hybrid-protein
#5
Heidi Hofer, Claudia Asam, Michael Hauser, Birgit Nagl, Josef Laimer, Martin Himly, Peter Briza, Christof Ebner, Roland Lang, Thomas Hawranek, Barbara Bohle, Peter Lackner, Fátima Ferreira, Michael Wallner
BACKGROUND: Allergy vaccines should be easily applicable, safe, and efficacious. For Bet v 1-mediated birch pollen and associated food allergies, a single wild-type allergen does not provide a complete solution. OBJECTIVE: We aimed to combine immunologically relevant epitopes of Bet v 1 and the 2 clinically most important related food allergens from apple and hazelnut to a single hybrid protein, termed MBC4. METHODS: After identification of T cell epitope-containing parts on each of the 3 parental allergens, the hybrid molecule was designed to cover relevant epitopes and evaluated in silico...
December 7, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27773482/regulatory-t-cell-specificity-directs-tolerance-versus-allergy-against-aeroantigens-in-humans
#6
Petra Bacher, Frederik Heinrich, Ulrik Stervbo, Mikalai Nienen, Marco Vahldieck, Christina Iwert, Katrin Vogt, Jutta Kollet, Nina Babel, Birgit Sawitzki, Carsten Schwarz, Stefan Bereswill, Markus M Heimesaat, Guido Heine, Gabriele Gadermaier, Claudia Asam, Mario Assenmacher, Olaf Kniemeyer, Axel A Brakhage, Fátima Ferreira, Michael Wallner, Margitta Worm, Alexander Scheffold
FOXP3+ regulatory T cells (Tregs) maintain tolerance against self-antigens and innocuous environmental antigens. However, it is still unknown whether Treg-mediated tolerance is antigen specific and how Treg specificity contributes to the selective loss of tolerance, as observed in human immunopathologies such as allergies. Here, we used antigen-reactive T cell enrichment to identify antigen-specific human Tregs. We demonstrate dominant Treg-mediated tolerance against particulate aeroallergens, such as pollen, house dust mites, and fungal spores...
October 18, 2016: Cell
https://www.readbyqxmd.com/read/27769198/knowledge-attitude-practice-and-associated-factors-towards-spectacles-use-among-adults-in-gondar-town-northwest-ethiopia
#7
Alemayehu Desalegn, Asamer Tsegaw, Destaye Shiferaw, Haile Woretaw
BACKGROUND: Refractive error is the main cause of visual impairment in the world. Spectacles are the most frequently used options for correcting refractive errors. In addition, they can be used for protection and fashion. It is the simplest, cheapest and only method used in developing countries like Ethiopia. This study aims to explore the knowledge, attitude, practice and associated factors towards spectacles use among adult population of Gondar town, northwest Ethiopia. METHODS: Community based cross sectional study was conducted on 780 participants using a pre-tested structured questionnaire in Gondar...
October 21, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27685684/society-news-asam-magazine
#8
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27471924/society-news-asam-magazine
#9
(no author information available yet)
No abstract text is available yet for this article.
July 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27466070/an-argument-for-change-in-tobacco-treatment-options-guided-by-the-asam-criteria-for-patient-placement
#10
Jill M Williams, Marc L Steinberg, Alexandra N Kenefake, Michael V Burke
Tobacco use is a major threat to public health in the United States, and the number one cause of preventable death. Although most smokers try to quit unaided, robust data indicate that pairing behavioral support to US Food Drug Administration-approved cessation medications significantly increase cessation rates. Those who do receive assistance in quitting usually receive very low intensity treatment, regardless of the severity of their dependence or their medical and environmental circumstances. This is in stark contrast to how other substance use disorders are treated, where there are varying levels of care depending on addiction severity and biopsychosocial circumstances...
September 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27462930/should-the-united-states-government-repeal-restrictions-on-buprenorphine-naloxone-treatment
#11
Kenneth Blum, Mark Gold, H Westley Clark, Kristina Dushaj, Rajendra D Badgaiyan
Attention must be focused on needed changes to the current United States law that restricts physicians who prescribe buprenorphine for the detoxification or treatment of Opioid Use Disorder, to accepting no more than 100 patients. The current system does not provide comprehensive treatment as defined by the American Society of Addiction Medicine (ASAM) criteria. In addition, it suffers from both fragmentation and stigma and will require a significant change to comply with ASAM's call for integrated delivery of comprehensive addiction treatment...
October 14, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/27429873/erratum-to-post-renal-biopsy-complication-rate-and-diagnostic-yield-comparing-hands-free-ultrasound-assisted-and-ultrasound-guided-biopsy-techniques-of-renal-allografts-and-native-kidneys
#12
Hatem Ali, Asam Murtaza, John Anderton, Aimun Ahmed
[This corrects the article DOI: 10.1186/s40064-015-1292-0.].
2016: SpringerPlus
https://www.readbyqxmd.com/read/27364115/recurrence-of-tubulointerstitial-nephritis-without-uveitis-in-a-patient-with-previous-tubulointerstitial-nephritis-and-uveitis-syndrome-after-transplant
#13
Asam Murtaza, Hatem Ali, Beena Nair, Aimun K Ahmed
We report a case of recurrent tubulointerstitial nephritis without uveitis in a patient with previous tubulointerstitial nephritis and uveitis syndrome after transplant. A 26-year-old male patient who had been diagnosed with tubulointerstitial nephritis and uveitis syndrome at 8 years of age developed end-stage renal failure and subsequently underwent living-donor related renal transplant at 17 years old. The 1st recurrence of tubulointerstitial nephritis and uveitis occurred 36 months after transplant, which was treated with increased immunosuppressive drugs...
June 29, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27223839/society-news-asam-magazine
#14
(no author information available yet)
No abstract text is available yet for this article.
May 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27180605/validated-uplc-ms-ms-methods-to-quantitate-free-and-conjugated-alternaria-toxins-in-commercially-available-tomato-products-and-fruit-and-vegetable-juices-in-belgium
#15
Jeroen Walravens, Hannes Mikula, Michael Rychlik, Stefan Asam, Tom Devos, Emmanuel Njumbe Ediage, José Diana Di Mavungu, Liesbeth Jacxsens, Anita Van Landschoot, Lynn Vanhaecke, Sarah De Saeger
Ultraperformance liquid chromatography tandem mass spectrometry and Quick, Easy, Cheap, Effective, Rugged, and Safe based analytical methodologies to quantitate both free (alternariol (1), alternariol monomethyl ether (2), tenuazonic acid (3), tentoxin (4), altenuene (5), altertoxin-I (6)) and conjugated (sulfates and glucosides of 1 and 2) Alternaria toxins in fruit and vegetable juices and tomato products were developed and validated. Acceptable limits of quantitation (0.7-5.7 μg/kg), repeatability (RSDr < 15...
June 22, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27129102/how-relevant-is-panallergen-sensitization-in-the-development-of-allergies
#16
REVIEW
Olivia E McKenna, Claudia Asam, Galber R Araujo, Anargyros Roulias, Luiz R Goulart, Fatima Ferreira
Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross-reactivity between related and unrelated allergenic sources. Such cross-reactivities include reactions between various pollen sources, pollen and plant-derived foods as well as invertebrate-derived inhalants and foodstuff. Here, we provide an overview on the most clinically relevant panallergens from plants (profilins, polcalcins, non-specific lipid transfer proteins, pathogenesis-related protein family 10 members) and on the prominent animal-derived panallergen family, tropomyosins...
September 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27087094/antioxidant-and-antiacetylcholine-esterase-potential-of-aerial-parts-of-conocarpus-erectus-ficus-variegata-and-ficus-maclellandii
#17
COMPARATIVE STUDY
Muhammad Asam Raza, Farwa Anwar, Durre Shahwar, Abdul Majeed, Muhammad Waseem Mumtaz, Muhammad Danish, Muhammad Faizan Nazar, Irum Perveen, Salah Ud-Din Khan
The current study was designed to check the antioxidant and enzyme inhibition potential of various extracts/ fractions of three selected plants. The aerial parts of Conocarpus erectus (Combretaceae), Ficus variegata (Moraceae) and Ficus maclellandii (Moraceae) were extracted with ethanol (95%) and the resulting crude extracts were partitioned with n-hexane, chloroform and n-butanol successively. Folin-Ciocalteu reagent was used to calculate the total phenolic contents, flavonoids contents were calculated with aluminum chloride while antioxidant and enzyme studies were carried out through standard protocols...
March 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27002515/pollen-allergens-for-molecular-diagnosis
#18
REVIEW
Isabel Pablos, Sabrina Wildner, Claudia Asam, Michael Wallner, Gabriele Gadermaier
Pollen allergens are one of the main causes of type I allergies affecting up to 30% of the population in industrialized countries. Climatic changes affect the duration and intensity of pollen seasons and may together with pollution contribute to increased incidences of respiratory allergy and asthma. Allergenic grasses, trees, and weeds often present similar habitats and flowering periods compromising clinical anamnesis. Molecule-based approaches enable distinction between genuine sensitization and clinically mostly irrelevant IgE cross-reactivity due to, e...
April 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/26985650/society-news-asam-magazine
#19
(no author information available yet)
No abstract text is available yet for this article.
March 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/26933875/specifying-and-pilot-testing-quality-measures-for-the-american-society-of-addiction-medicine-s-standards-of-care
#20
Alex H S Harris, Constance M Weisner, Mady Chalk, Victor Capoccia, Cheng Chen, Cindy Parks Thomas
OBJECTIVES: In 2013, the American Society of Addiction Medicine (ASAM) approved its Standards of Care for the Addiction Specialist Physician. Subsequently, an ASAM Performance Measures Panel identified and prioritized the standards to be operationalized into performance measures. The goal of this study is to describe the process of operationalizing 3 of these standards into quality measures, and to present the initial measure specifications and results of pilot testing these measures in a large health care system...
May 2016: Journal of Addiction Medicine
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