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Michael Reich

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https://www.readbyqxmd.com/read/28905403/infectious-disease-prediction-with-kernel-conditional-density-estimation
#1
Evan L Ray, Krzysztof Sakrejda, Stephen A Lauer, Michael A Johansson, Nicholas G Reich
Creating statistical models that generate accurate predictions of infectious disease incidence is a challenging problem whose solution could benefit public health decision makers. We develop a new approach to this problem using kernel conditional density estimation (KCDE) and copulas. We obtain predictive distributions for incidence in individual weeks using KCDE and tie those distributions together into joint distributions using copulas. This strategy enables us to create predictions for the timing of and incidence in the peak week of the season...
September 14, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28878828/elevated-serum-interleukin-6-is-predictive-of-coronary-artery-disease-in-intermediate-risk-overweight-patients-referred-for-coronary-angiography
#2
Marco V Wainstein, Márcio Mossmann, Gustavo N Araujo, Sandro C Gonçalves, Gabriela L Gravina, Marlei Sangalli, Francine Veadrigo, Roselene Matte, Rejane Reich, Fernanda G Costa, Michael Andrades, Antônio Marcos V da Silva, Marcello C Bertoluci
BACKGROUND: Interleukin-6 (IL-6) plays a central role in atherosclerosis and inflammation. It may improve risk prediction in patients at intermediate cardiovascular risk. OBJECTIVE: To analyze the impact of serum IL-6 in predicting early angiographic coronary artery disease in patients at intermediate cardiovascular risk with chest pain. METHODS: In a cross-sectional study, patients referred for coronary angiography due to suspected coronary artery disease (CAD) were included...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28873982/-forgotten-chapters-in-the-history-of-transcervical-sterilization-carl-clauberg-and-hans-joachim-lindemann
#3
Sabine Hildebrandt, Susan Benedict, Erin Miller, Michael Gaffney, Michael A Grodin
Transcervical sterilization is a non-surgical method of permanent female sterilization that is widely used and critically discussed. A review of the historiography of the method reveals that instances of its coercive use are not included in the historical account. This study offers a reexamination of the work of Carl Clauberg and Hans-Joachim Lindemann, to more deeply contextualize within the framework of current usage the coercive use of transcervical sterilization during the Third Reich and in postwar Germany...
July 1, 2017: Journal of the History of Medicine and Allied Sciences
https://www.readbyqxmd.com/read/28852333/perioperative-considerations-when-treating-isolated-periprosthetic-distal-femur-fractures
#4
Michael S Reich, Mindy Duong, Mary A Breslin, Mai P Nguyen, Heather A Vallier
BACKGROUND: Periprosthetic distal femur (PPDF) fractures occur most frequently via low energy mechanisms in elderly patients. This population is often frail and ill-suited to the physiologic burden of trauma and surgery. Here, we describe the perioperative and early hospital course for patients with PPDF fractures, and identify risk factors for poor outcomes. METHODS: Consecutive patients with isolated PPDF fractures from 2005 - 2015 were treated operatively at a Level I trauma center...
2017: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/28822753/the-genepattern-notebook-environment
#5
Michael Reich, Thorin Tabor, Ted Liefeld, Helga Thorvaldsdóttir, Barbara Hill, Pablo Tamayo, Jill P Mesirov
Interactive analysis notebook environments promise to streamline genomics research through interleaving text, multimedia, and executable code into unified, sharable, reproducible "research narratives." However, current notebook systems require programming knowledge, limiting their wider adoption by the research community. We have developed the GenePattern Notebook environment (http://www.genepattern-notebook.org), to our knowledge the first system to integrate the dynamic capabilities of notebook systems with an investigator-focused, easy-to-use interface that provides access to hundreds of genomic tools without the need to write code...
August 23, 2017: Cell Systems
https://www.readbyqxmd.com/read/28783727/genetic-origins-of-the-minoans-and-mycenaeans
#6
Iosif Lazaridis, Alissa Mittnik, Nick Patterson, Swapan Mallick, Nadin Rohland, Saskia Pfrengle, Anja Furtwängler, Alexander Peltzer, Cosimo Posth, Andonis Vasilakis, P J P McGeorge, Eleni Konsolaki-Yannopoulou, George Korres, Holley Martlew, Manolis Michalodimitrakis, Mehmet Özsait, Nesrin Özsait, Anastasia Papathanasiou, Michael Richards, Songül Alpaslan Roodenberg, Yannis Tzedakis, Robert Arnott, Daniel M Fernandes, Jeffery R Hughey, Dimitra M Lotakis, Patrick A Navas, Yannis Maniatis, John A Stamatoyannopoulos, Kristin Stewardson, Philipp Stockhammer, Ron Pinhasi, David Reich, Johannes Krause, George Stamatoyannopoulos
The origins of the Bronze Age Minoan and Mycenaean cultures have puzzled archaeologists for more than a century. We have assembled genome-wide data from 19 ancient individuals, including Minoans from Crete, Mycenaeans from mainland Greece, and their eastern neighbours from southwestern Anatolia. Here we show that Minoans and Mycenaeans were genetically similar, having at least three-quarters of their ancestry from the first Neolithic farmers of western Anatolia and the Aegean, and most of the remainder from ancient populations related to those of the Caucasus and Iran...
August 10, 2017: Nature
https://www.readbyqxmd.com/read/28760408/relationship-between-serum-inflammatory-markers-and-vascular-function-in-a-cohort-of-adolescents-with-type-1-diabetes
#7
Etienne Sochett, Damien Noone, Michael Grattan, Cameron Slorach, Rahim Moineddin, Yesmino Elia, Farid H Mahmud, David B Dunger, Neil Dalton, David Cherney, James Scholey, Heather Reich, John Deanfield
OBJECTIVE: The contribution of inflammation to endothelial/vascular dysfunction in early Type I Diabetes (T1D) is not well understood. The objective of this study was to examine the interaction between systemic inflammation and vascular function in adolescent's with and without-T1D. METHODS: 51 subjects from our observational cohort of adolescents with T1D (JDRF-CCTN), and 59 healthy controls (HC) were studied. Serum cytokines-chemokines were quantified using Human 41-Plex Array, and vascular function was measured by Flow Mediated Dilatation (FMD), Pulse Wave Velocity (PWV) and Blood Pressure (BP)...
July 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28725403/potential-and-limitations-of-inferring-ecosystem-photosynthetic-capacity-from-leaf-functional-traits
#8
Talie Musavi, Mirco Migliavacca, Martine Janet van de Weg, Jens Kattge, Georg Wohlfahrt, Peter M van Bodegom, Markus Reichstein, Michael Bahn, Arnaud Carrara, Tomas F Domingues, Michael Gavazzi, Damiano Gianelle, Cristina Gimeno, André Granier, Carsten Gruening, Kateřina Havránková, Mathias Herbst, Charmaine Hrynkiw, Aram Kalhori, Thomas Kaminski, Katja Klumpp, Pasi Kolari, Bernard Longdoz, Stefano Minerbi, Leonardo Montagnani, Eddy Moors, Walter C Oechel, Peter B Reich, Shani Rohatyn, Alessandra Rossi, Eyal Rotenberg, Andrej Varlagin, Matthew Wilkinson, Christian Wirth, Miguel D Mahecha
The aim of this study was to systematically analyze the potential and limitations of using plant functional trait observations from global databases versus in situ data to improve our understanding of vegetation impacts on ecosystem functional properties (EFPs). Using ecosystem photosynthetic capacity as an example, we first provide an objective approach to derive robust EFP estimates from gross primary productivity (GPP) obtained from eddy covariance flux measurements. Second, we investigate the impact of synchronizing EFPs and plant functional traits in time and space to evaluate their relationships, and the extent to which we can benefit from global plant trait databases to explain the variability of ecosystem photosynthetic capacity...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28649995/cytokines-in-systemic-lupus-erythematosus-far-beyond-th1-th2-dualism
#9
Poliana Macedo Guimarães, Bruna Miglioranza Scavuzzi, Nicole Perugini Stadtlober, Lorena Flor da Rosa Santos Silva, Marcell Alysson Batisti Lozovoy, Tathiana Mayumi Veiga Iriyoda, Neide Tomimura Costa, Edna Maria Vissoci Reiche, Michael Maes, Isaias Dichi, Andréa Name Colado Simão
The aims of this study were to delineate cytokines profiles of systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, and to examine the associations between TNFB Ncol polymorphism, body mass index (BMI), and vitamin D levels with cytokine levels. 200 SLE patients and 196 healthy controls participated in this case-control study. Plasma cytokines levels of TNF-α, IFN-γ, IL-1β, IL- 4, IL-6, IL-10, IL-12, IL-17 were measured and cytokines profiles were computed...
June 26, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28648302/nephrotic-syndrome-with-cancer-immunotherapies-a-report-of-2-cases
#10
Abhijat Kitchlu, Warren Fingrut, Carmen Avila-Casado, Christopher T Chan, Michael Crump, David Hogg, Heather N Reich
Oncologic immunotherapies use a patient's immune response to eliminate tumor cells by modulation of immune checkpoints, including programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) proteins. Immune-mediated sequelae, including interstitial nephritis, have been reported; however, glomerular disease appears rare. We describe 2 cases of nephrotic syndrome in patients treated with these agents. Patient 1 received the anti-PD-1 antibody pembrolizumab for Hodgkin lymphoma. Following his second dose, he developed nephrotic syndrome and acute kidney injury...
June 22, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28609656/kupffer-cell-derived-tnf-triggers-cholangiocellular-tumorigenesis-through-jnk-due-to-chronic-mitochondrial-dysfunction-and-ros
#11
Detian Yuan, Shan Huang, Emanuel Berger, Lei Liu, Nina Gross, Florian Heinzmann, Marc Ringelhan, Tracy O Connor, Mira Stadler, Michael Meister, Julia Weber, Rupert Öllinger, Nicole Simonavicius, Florian Reisinger, Daniel Hartmann, Rüdiger Meyer, Maria Reich, Marco Seehawer, Valentina Leone, Bastian Höchst, Dirk Wohlleber, Simone Jörs, Marco Prinz, Duncan Spalding, Ulrike Protzer, Tom Luedde, Luigi Terracciano, Matthias Matter, Thomas Longerich, Percy Knolle, Thomas Ried, Verena Keitel, Fabian Geisler, Kristian Unger, Einat Cinnamon, Eli Pikarsky, Norbert Hüser, Roger J Davis, Darjus F Tschaharganeh, Roland Rad, Achim Weber, Lars Zender, Dirk Haller, Mathias Heikenwalder
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant, heterogeneous cancer with poor treatment options. We found that mitochondrial dysfunction and oxidative stress trigger a niche favoring cholangiocellular overgrowth and tumorigenesis. Liver damage, reactive oxygen species (ROS) and paracrine tumor necrosis factor (Tnf) from Kupffer cells caused JNK-mediated cholangiocellular proliferation and oncogenic transformation. Anti-oxidant treatment, Kupffer cell depletion, Tnfr1 deletion, or JNK inhibition reduced cholangiocellular pre-neoplastic lesions...
June 12, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28586141/connectivity-predicts-deep-brain-stimulation-outcome-in-parkinson-disease
#12
Andreas Horn, Martin Reich, Johannes Vorwerk, Ningfei Li, Gregor Wenzel, Qianqian Fang, Tanja Schmitz-Hübsch, Robert Nickl, Andreas Kupsch, Jens Volkmann, Andrea A Kühn, Michael D Fox
OBJECTIVE: The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may depend on connectivity between the stimulation site and other brain regions, but which regions and whether connectivity can predict outcome in patients remain unknown. Here, we identify the structural and functional connectivity profile of effective DBS to the subthalamic nucleus (STN) and test its ability to predict outcome in an independent cohort. METHODS: A training dataset of 51 PD patients with STN DBS was combined with publicly available human connectome data (diffusion tractography and resting state functional connectivity) to identify connections reliably associated with clinical improvement (motor score of the Unified Parkinson Disease Rating Scale [UPDRS])...
July 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28585920/palaeogenomes-of-eurasian-straight-tusked-elephants-challenge-the-current-view-of-elephant-evolution
#13
Matthias Meyer, Eleftheria Palkopoulou, Sina Baleka, Mathias Stiller, Kirsty E H Penkman, Kurt W Alt, Yasuko Ishida, Dietrich Mania, Swapan Mallick, Tom Meijer, Harald Meller, Sarah Nagel, Birgit Nickel, Sven Ostritz, Nadin Rohland, Karol Schauer, Tim Schüler, Alfred L Roca, David Reich, Beth Shapiro, Michael Hofreiter
The straight-tusked elephants Palaeoloxodon spp. were widespread across Eurasia during the Pleistocene. Phylogenetic reconstructions using morphological traits have grouped them with Asian elephants (Elephas maximus), and many paleontologists place Palaeoloxodon within Elephas. Here, we report the recovery of full mitochondrial genomes from four and partial nuclear genomes from two P. antiquus fossils. These fossils were collected at two sites in Germany, Neumark-Nord and Weimar-Ehringsdorf, and likely date to interglacial periods ~120 and ~244 thousand years ago, respectively...
June 6, 2017: ELife
https://www.readbyqxmd.com/read/28423023/nanoscale-modifications-in-the-early-heating-stages-of-bone-are-heterogeneous-at-the-microstructural-scale
#14
Aurélien Gourrier, Céline Chadefaux, Estelle Lemaitre, Ludovic Bellot-Gurlet, Michael Reynolds, Manfred Burghammer, Marie Plazanet, Georges Boivin, Delphine Farlay, Oliver Bunk, Ina Reiche
Nanoscale studies of bone provide key indicators to evidence subtle structural changes that may occur in the biomedical, forensic and archaeological contexts. One specific problem encountered in all those disciplines, for which the identification of nanostructural cues could prove useful, is to properly monitor the effect of heating on bone tissue. In particular, the mechanisms at work at the onset of heating are still relatively unclear. Using a multiscale approach combining Raman microspectroscopy, transmission electron microscopy (TEM), synchrotron quantitative scanning small-angle X-ray scattering imaging (qsSAXSI) and polarized light (PL) microscopy, we investigate the ultrastructure of cortical bovine bone heated at temperatures < 300°C, from the molecular to the macroscopic scale...
2017: PloS One
https://www.readbyqxmd.com/read/28396877/visual-and-refractive-outcomes-following-implantation-of-a-new-trifocal-intraocular-lens
#15
Michael Lawless, Chris Hodge, Joe Reich, Lewis Levitz, Uday K Bhatt, Colm McAlinden, Kate Roberts, Timothy V Roberts
BACKGROUND: Independence from all optical aids, and freedom from unwanted symptoms, following cataract and lens surgery remains the ultimate goal of both patient and surgeon. The development of trifocal IOL technology provides an ever-increasing range of options. The purpose of our study is to understand the predictability, safety and efficacy of a new trifocal intraocular lens (IOL) following cataract or refractive lens exchange (RLE) surgery. METHODS: This was a retrospective consecutive case series of patients undergoing cataract extraction or RLE followed by implantation of the Alcon IQ Panoptix IOL...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28342209/from-somatic-pain-to-psychic-pain-the-body-in-the-psychoanalytic-field
#16
Thomas Hartung, Michael Steinbrecher
The integration of psyche and soma begins with a baby's earliest contact with his or her parents. With the help of maternal empathy and reverie, β-elements are transformed into α-elements. While we understand this to be the case, we would like to enquire what actually happens to those parts of the affect which have not been transformed? For the most part they may be dealt with by evacuation, but they can also remain within the body, subsequently contributing to psychosomatic symptoms. This paper describes how the body serves as an intermediate store between the psychic (inner) and outer reality...
March 24, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28255729/make-the-most-of-the-data-you-ve-got-bayesian-models-and-a-surrogate-species-approach-to-assessing-benefits-of-upstream-migration-flows-for-the-endangered-australian-grayling
#17
J Angus Webb, Wayne M Koster, Ivor G Stuart, Paul Reich, Michael J Stewardson
Environmental water managers must make best use of allocations, and adaptive management is one means of improving effectiveness of environmental water delivery. Adaptive management relies on generation of new knowledge from monitoring and evaluation, but it is often difficult to make clear inferences from available monitoring data. Alternative approaches to assessment of flow benefits may offer an improved pathway to adaptive management. We developed Bayesian statistical models to inform adaptive management of the threatened Australian grayling (Prototroctes maraena) in the coastal Thomson River, South-East Victoria Australia...
March 3, 2017: Environmental Management
https://www.readbyqxmd.com/read/28240620/infection-rates-and-treatment-of-low-velocity-extremity-gunshot-injuries
#18
Mai P Nguyen, Jonathan C Savakus, Jeffrey A OʼDonnell, Nicholas F Prayson, Michael S Reich, Joseph F Golob, Amy A McDonald, John J Como, Heather A Vallier
OBJECTIVES: To determine the rates of infection in low-energy gunshot wounds (GSWs) to the extremity. DESIGN: Retrospective review. SETTING: Level I trauma center. PATIENTS/PARTICIPANTS: Patients (N = 140) with at least 90-day follow-up for extremity-only low-energy GSW injuries from 2010-2014 were retrospectively reviewed. Treatment was recorded, including type and duration of antibiotics and details of nonoperative and operative managements...
June 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28230571/infection-and-complications-after-low-velocity-intra-articular-gunshot-injuries
#19
Mai P Nguyen, Michael S Reich, Jeffrey A OʼDonnell, Jonathan C Savakus, Nicholas F Prayson, Joseph F Golob, Amy A McDonald, John J Como, Heather A Vallier
OBJECTIVES: The purpose of this study is to characterize the demographics, interventions, infection rates, and other complications after intra-articular (IA) gunshot wounds. DESIGN: Retrospective review. SETTING: Level I trauma center. PATIENTS/PARTICIPANTS: Fifty-three patients with 55 civilian low-velocity IA gunshot injuries with a minimum of 4 weeks follow-up were included in the study. Seven patients had associated vascular injuries...
June 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28196044/is-oxinium-losing-its-luster-commentary-on-an-article-by-christopher-j-vertullo-mbbs-fracs-orth-faortha-et-al-twelve-year-outcomes-of-an-oxinium-total-knee-replacement-compared-with-the-same-cobalt-chromium-design-an-analysis-of-17-577-prostheses-from-the-australian
#20
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