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Michael Reich

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https://www.readbyqxmd.com/read/28423023/nanoscale-modifications-in-the-early-heating-stages-of-bone-are-heterogeneous-at-the-microstructural-scale
#1
Aurélien Gourrier, Céline Chadefaux, Estelle Lemaitre, Ludovic Bellot-Gurlet, Michael Reynolds, Manfred Burghammer, Marie Plazanet, Georges Boivin, Delphine Farlay, Oliver Bunk, Ina Reiche
Nanoscale studies of bone provide key indicators to evidence subtle structural changes that may occur in the biomedical, forensic and archaeological contexts. One specific problem encountered in all those disciplines, for which the identification of nanostructural cues could prove useful, is to properly monitor the effect of heating on bone tissue. In particular, the mechanisms at work at the onset of heating are still relatively unclear. Using a multiscale approach combining Raman microspectroscopy, transmission electron microscopy (TEM), synchrotron quantitative scanning small-angle X-ray scattering imaging (qsSAXSI) and polarized light (PL) microscopy, we investigate the ultrastructure of cortical bovine bone heated at temperatures < 300°C, from the molecular to the macroscopic scale...
2017: PloS One
https://www.readbyqxmd.com/read/28396877/visual-and-refractive-outcomes-following-implantation-of-a-new-trifocal-intraocular-lens
#2
Michael Lawless, Chris Hodge, Joe Reich, Lewis Levitz, Uday K Bhatt, Colm McAlinden, Kate Roberts, Timothy V Roberts
BACKGROUND: Independence from all optical aids, and freedom from unwanted symptoms, following cataract and lens surgery remains the ultimate goal of both patient and surgeon. The development of trifocal IOL technology provides an ever-increasing range of options. The purpose of our study is to understand the predictability, safety and efficacy of a new trifocal intraocular lens (IOL) following cataract or refractive lens exchange (RLE) surgery. METHODS: This was a retrospective consecutive case series of patients undergoing cataract extraction or RLE followed by implantation of the Alcon IQ Panoptix IOL...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28342209/from-somatic-pain-to-psychic-pain-the-body-in-the-psychoanalytic-field
#3
Thomas Hartung, Michael Steinbrecher
The integration of psyche and soma begins with a baby's earliest contact with his or her parents. With the help of maternal empathy and reverie, β-elements are transformed into α-elements. While we understand this to be the case, we would like to enquire what actually happens to those parts of the affect which have not been transformed? For the most part they may be dealt with by evacuation, but they can also remain within the body, subsequently contributing to psychosomatic symptoms. This paper describes how the body serves as an intermediate store between the psychic (inner) and outer reality...
March 24, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28255729/make-the-most-of-the-data-you-ve-got-bayesian-models-and-a-surrogate-species-approach-to-assessing-benefits-of-upstream-migration-flows-for-the-endangered-australian-grayling
#4
J Angus Webb, Wayne M Koster, Ivor G Stuart, Paul Reich, Michael J Stewardson
Environmental water managers must make best use of allocations, and adaptive management is one means of improving effectiveness of environmental water delivery. Adaptive management relies on generation of new knowledge from monitoring and evaluation, but it is often difficult to make clear inferences from available monitoring data. Alternative approaches to assessment of flow benefits may offer an improved pathway to adaptive management. We developed Bayesian statistical models to inform adaptive management of the threatened Australian grayling (Prototroctes maraena) in the coastal Thomson River, South-East Victoria Australia...
March 3, 2017: Environmental Management
https://www.readbyqxmd.com/read/28240620/infection-rates-and-treatment-of-low-velocity-extremity-gunshot-injuries
#5
Mai P Nguyen, Jonathan C Savakus, Jeffrey A O'Donnell, Nicholas F Prayson, Michael S Reich, Joseph F Golob, Amy A McDonald, John J Como, Heather A Vallier
OBJECTIVES: To determine the rates of infection in low-energy gunshot wounds (GSWs) to the extremity. DESIGN: Retrospective review. SETTING: Level I trauma center. PATIENTS/PARTICIPANTS: Patients (N=140) with at least 90-day follow-up for extremity-only low-energy GSW injuries from 2010-2014 were retrospectively reviewed. Treatment was recorded, including type and duration of antibiotics and details of non-operative and operative management...
February 23, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28230571/infection-and-complications-following-low-velocity-intra-articular-gunshot-injuries
#6
Mai P Nguyen, Michael S Reich, Jeffrey A O'Donnell, Jonathan C Savakus, Nicholas F Prayson, Joseph F Golob, Amy A McDonald, John J Como, Heather A Vallier
OBJECTIVES: The purpose of this study is to characterize the demographics, interventions, infection rates, and other complications following intra-articular gunshot wounds. DESIGN: Retrospective review. SETTING: Level I trauma center. PATIENTS/PARTICIPANTS: Fifty-three patients with 55 civilian low-velocity intra-articular gunshot injuries with a minimum of four weeks follow-up were included in the study. Seven patients had associated vascular injuries...
February 20, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28196044/is-oxinium-losing-its-luster-commentary-on-an-article-by-christopher-j-vertullo-mbbs-fracs-orth-faortha-et-al-twelve-year-outcomes-of-an-oxinium-total-knee-replacement-compared-with-the-same-cobalt-chromium-design-an-analysis-of-17-577-prostheses-from-the-australian
#7
https://www.readbyqxmd.com/read/28152396/insulin-resistance-atherogenicity-and-iron-metabolism-in-multiple-sclerosis-with-and-without-depression-associations-with-inflammatory-and-oxidative-stress-biomarkers-and-uric-acid
#8
Sayonara Rangel Oliveira, Ana Paula Kallaur, Josiane Lopes, Andrea Name Colado Simão, Edna Maria Vissoci Reiche, Elaine Regina Delicato de Almeida, Helena Kaminami Morimoto, Wildea Lice de Carvalho Jennings de Pereira, Daniela Frizon Alfieri, Tamires Flauzino, Caio de Meleck Proença, Anna Maria Gomes, Damacio Ramón Kaimen-Maciel, Michael Maes
Depression is accompanied by metabolic disorders in iron metabolism, lipoproteins, and insulin resistance. We measured plasma levels of ferritin, iron, lipids, insulin, and glucose and computed the homeostasis model assessment (HOMA2IR) and atherogenic index of plasma (AIP) in MS patients with and without depression and healthy controls. Explanatory variables were serum uric acid, interleukin (IL)-6, lipid hydroperoxides (CL-LOOH), albumin, and C-reactive protein (CRP). Depression was assessed using the Hospital Anxiety and Depression Scale (HADS), neurological disability using the Expanded Disability Status Scale (EDSS), and disease progression using ∆EDSS over five years earlier...
April 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28088579/the-microrna-449-family-inhibits-tgf-%C3%AE-mediated-liver-cancer-cell-migration-by-targeting-sox4
#9
Maria Sandbothe, Reena Buurman, Nicole Reich, Luisa Greiwe, Beate Vajen, Engin Gürlevik, Vera Schäffer, Marlies Eilers, Florian Kühnel, Alejandro Vaquero, Thomas Longerich, Stephanie Roessler, Peter Schirmacher, Michael P Manns, Thomas Illig, Brigitte Schlegelberger, Britta Skawran
BACKGROUND & AIMS: Modulation of microRNA expression is a potential treatment for hepatocellular carcinoma (HCC). Therefore, the epigenetically regulated microRNA-449 family (miR-449a, miR-449b, miR-449c) was characterized with regards to its functional effects and target genes in HCC. METHODS: After transfection of miR-449a, miR-449b, and/or miR-449c, tumor-relevant functional effects were analyzed using in vitro assays and a xenograft mouse model. Binding specificities, target genes, and regulated pathways of each miRNA were identified by microarray analyses...
January 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28060239/a-risk-factor-out-of-control-commentary-on-an-article-by-alon-ben-ari-md-et-al-preoperative-opioid-use-is-associated-with-early-revision-after-total-knee-arthroplasty-a-study-of-male-patients-treated-in-the-veterans-affairs-system
#10
https://www.readbyqxmd.com/read/28057361/efficacy-and-safety-of-guselkumab-an-anti-interleukin-23-monoclonal-antibody-compared-with-adalimumab-for-the-treatment-of-patients-with-moderate-to-severe-psoriasis-with-randomized-withdrawal-and-retreatment-results-from-the-phase-iii-double-blind-placebo
#11
RANDOMIZED CONTROLLED TRIAL
Kristian Reich, April W Armstrong, Peter Foley, Michael Song, Yasmine Wasfi, Bruce Randazzo, Shu Li, Y-K Shen, Kenneth B Gordon
BACKGROUND: Phase II data suggested that guselkumab, an anti-interleukin-23 monoclonal antibody, was efficacious in psoriasis. OBJECTIVE: We sought to assess efficacy and safety of guselkumab in moderate to severe psoriasis versus placebo and adalimumab, including interrupted treatment and switching adalimumab nonresponders to guselkumab. METHODS: Patients were randomized to guselkumab 100 mg (weeks 0 and 4, then every 8 weeks; n = 496); placebo→guselkumab (weeks 0, 4, and 12 then guselkumab at weeks 16 and 20; n = 248); or adalimumab (80 mg week 0, then 40 mg week 1, and every 2 weeks through week 23; n = 248)...
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27832874/essential-medicines-for-universal-health-coverage
#12
REVIEW
Veronika J Wirtz, Hans V Hogerzeil, Andrew L Gray, Maryam Bigdeli, Cornelis P de Joncheere, Margaret A Ewen, Martha Gyansa-Lutterodt, Sun Jing, Vera L Luiza, Regina M Mbindyo, Helene Möller, Corrina Moucheraud, Bernard Pécoul, Lembit Rägo, Arash Rashidian, Dennis Ross-Degnan, Peter N Stephens, Yot Teerawattananon, Ellen F M 't Hoen, Anita K Wagner, Prashant Yadav, Michael R Reich
No abstract text is available yet for this article.
November 4, 2016: Lancet
https://www.readbyqxmd.com/read/27816061/political-economy-challenges-in-nutrition
#13
Yarlini Balarajan, Michael R Reich
BACKGROUND: Historically, implementing nutrition policy has confronted persistent obstacles, with many of these obstacles arising from political economy sources. While there has been increased global policy attention to improving nutrition in recent years, the difficulty of translating this policy momentum into results remains. DISCUSSION: We present key political economy themes emanating from the political economy of nutrition literature. Together, these interrelated themes create a complex web of obstacles to moving nutrition policy forward...
November 5, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27786572/haplo-cord-transplant-hla-matching-determines-graft-dominance
#14
Koen van Besien, Nebu Koshy, Usama Gergis, Sebastian Mayer, Melissa Cushing, Hannah Rennert, Ronit Reich-Slotky, Tomer Mark, Roger Pearse, Adriana Rossi, Adrienne Phillips, Liljana Vasovic, Rosanna Ferrante, Yen-Michael Hsu, Tsiporah Shore
No abstract text is available yet for this article.
October 27, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27771325/latent-class-analysis-reveals-clinically-relevant-atopy-phenotypes-in-2-birth-cohorts
#15
Alexander J Hose, Martin Depner, Sabina Illi, Susanne Lau, Thomas Keil, Ulrich Wahn, Oliver Fuchs, Petra Ina Pfefferle, Elisabeth Schmaußer-Hechfellner, Jon Genuneit, Roger Lauener, Anne M Karvonen, Caroline Roduit, Jean-Charles Dalphin, Josef Riedler, Juha Pekkanen, Erika von Mutius, Markus J Ege
BACKGROUND: Phenotypes of childhood-onset asthma are characterized by distinct trajectories and functional features. For atopy, definition of phenotypes during childhood is less clear. OBJECTIVE: We sought to define phenotypes of atopic sensitization over the first 6 years of life using a latent class analysis (LCA) integrating 3 dimensions of atopy: allergen specificity, time course, and levels of specific IgE (sIgE). METHODS: Phenotypes were defined by means of LCA in 680 children of the Multizentrische Allergiestudie (MAS) and 766 children of the Protection against allergy: Study in Rural Environments (PASTURE) birth cohorts and compared with classical nondisjunctive definitions of seasonal, perennial, and food sensitization with respect to atopic diseases and lung function...
October 19, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27744425/german-neurology-and-the-third-reich
#16
Michael Martin, Heiner Fangerau, Axel Karenberg
BACKGROUND: This paper summarizes the current state of research into the role of German neurology during National Socialism (NS) on the basis of extensive secondary literature and key original sources. SUMMARY: As early as 1933, many neurologists and neuroscientists who had been branded as 'non-Aryan' and/or politically persecuted had to leave Germany, were driven to suicide or killed in concentration camps. Two years later, the regulatory merger with the Psychiatrists' Association caused the cautious attempts of the institutionally hampered discipline for autonomy to end in complete failure...
2016: European Neurology
https://www.readbyqxmd.com/read/27738143/positive-biodiversity-productivity-relationship-predominant-in-global-forests
#17
Jingjing Liang, Thomas W Crowther, Nicolas Picard, Susan Wiser, Mo Zhou, Giorgio Alberti, Ernst-Detlef Schulze, A David McGuire, Fabio Bozzato, Hans Pretzsch, Sergio de-Miguel, Alain Paquette, Bruno Hérault, Michael Scherer-Lorenzen, Christopher B Barrett, Henry B Glick, Geerten M Hengeveld, Gert-Jan Nabuurs, Sebastian Pfautsch, Helder Viana, Alexander C Vibrans, Christian Ammer, Peter Schall, David Verbyla, Nadja Tchebakova, Markus Fischer, James V Watson, Han Y H Chen, Xiangdong Lei, Mart-Jan Schelhaas, Huicui Lu, Damiano Gianelle, Elena I Parfenova, Christian Salas, Eungul Lee, Boknam Lee, Hyun Seok Kim, Helge Bruelheide, David A Coomes, Daniel Piotto, Terry Sunderland, Bernhard Schmid, Sylvie Gourlet-Fleury, Bonaventure Sonké, Rebecca Tavani, Jun Zhu, Susanne Brandl, Jordi Vayreda, Fumiaki Kitahara, Eric B Searle, Victor J Neldner, Michael R Ngugi, Christopher Baraloto, Lorenzo Frizzera, Radomir Bałazy, Jacek Oleksyn, Tomasz Zawiła-Niedźwiecki, Olivier Bouriaud, Filippo Bussotti, Leena Finér, Bogdan Jaroszewicz, Tommaso Jucker, Fernando Valladares, Andrzej M Jagodzinski, Pablo L Peri, Christelle Gonmadje, William Marthy, Timothy O'Brien, Emanuel H Martin, Andrew R Marshall, Francesco Rovero, Robert Bitariho, Pascal A Niklaus, Patricia Alvarez-Loayza, Nurdin Chamuya, Renato Valencia, Frédéric Mortier, Verginia Wortel, Nestor L Engone-Obiang, Leandro V Ferreira, David E Odeke, Rodolfo M Vasquez, Simon L Lewis, Peter B Reich
The biodiversity-productivity relationship (BPR) is foundational to our understanding of the global extinction crisis and its impacts on ecosystem functioning. Understanding BPR is critical for the accurate valuation and effective conservation of biodiversity. Using ground-sourced data from 777,126 permanent plots, spanning 44 countries and most terrestrial biomes, we reveal a globally consistent positive concave-down BPR, showing that continued biodiversity loss would result in an accelerating decline in forest productivity worldwide...
October 14, 2016: Science
https://www.readbyqxmd.com/read/27665707/evaluating-the-performance-of-infectious-disease-forecasts-a-comparison-of-climate-driven-and-seasonal-dengue-forecasts-for-mexico
#18
Michael A Johansson, Nicholas G Reich, Aditi Hota, John S Brownstein, Mauricio Santillana
Dengue viruses, which infect millions of people per year worldwide, cause large epidemics that strain healthcare systems. Despite diverse efforts to develop forecasting tools including autoregressive time series, climate-driven statistical, and mechanistic biological models, little work has been done to understand the contribution of different components to improved prediction. We developed a framework to assess and compare dengue forecasts produced from different types of models and evaluated the performance of seasonal autoregressive models with and without climate variables for forecasting dengue incidence in Mexico...
September 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27663079/secukinumab-is-superior-to-ustekinumab-in-clearing-skin-of-subjects-with-moderate-to-severe-plaque-psoriasis-up-to-1%C3%A2-year-results-from-the-clear-study
#19
RANDOMIZED CONTROLLED TRIAL
Andrew Blauvelt, Kristian Reich, Tsen-Fang Tsai, Stephen Tyring, Francisco Vanaclocha, Külli Kingo, Michael Ziv, Andreas Pinter, Ronald Vender, Sophie Hugot, Ruquan You, Marina Milutinovic, Diamant Thaçi
BACKGROUND: Secukinumab demonstrated superior efficacy to ustekinumab at week 4 and week 16 of the CLEAR study, with comparable safety, in subjects with moderate-to-severe plaque psoriasis. OBJECTIVE: To compare the efficacy and safety of secukinumab and ustekinumab use over 52 weeks. METHODS: Analysis of 52-week data from CLEAR, a randomized, double-blind, phase 3b study. RESULTS: Among 676 randomized subjects, secukinumab demonstrated superiority to ustekinumab at week 52 in the proportion of subjects with ≥90% improvement in Psoriasis Area and Severity Index (PASI 90) (76% vs 61% [P < ...
January 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27648638/lysophosphatidic-acids-and-autotaxin-in-retinal-vein-occlusion
#20
Ivanka Dacheva, Christoph Ullmer, Karolina Ceglowska, Everson Nogoceke, Guido Hartmann, Stephan Müller, Robert Rejdak, Katarzyna Nowomiejska, Michael Reich, Matthias Nobl, Tamer Tandogan, Florian T A Kretz, Gerd U Auffarth, Michael J Koss
PURPOSE: To analyze the levels of lysophosphatidic acids (LPAs) and autotaxin (ATX) in undiluted vitreous of untreated patients with retinal vein occlusion (RVO). METHODS: Sixty-four vitreous samples (40 RVO, 24 controls with idiopathic floaters) were analyzed in this retrospective case series using LC/MS for LPAs 16:0, 18:0, 18:1, 20:4, and ELISA kits or Luminex technology for ATX, angiopoetin-1 (ANG-1), interleukin-6 (IL-6), interleukin-7 (IL-7), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), pigment epithelium-derived factor (PEDF), and vascular endothelial growth factor (VEGF)...
December 2016: Retina
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