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Michael Reich

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https://www.readbyqxmd.com/read/27832874/essential-medicines-for-universal-health-coverage
#1
REVIEW
Veronika J Wirtz, Hans V Hogerzeil, Andrew L Gray, Maryam Bigdeli, Cornelis P de Joncheere, Margaret A Ewen, Martha Gyansa-Lutterodt, Sun Jing, Vera L Luiza, Regina M Mbindyo, Helene Möller, Corrina Moucheraud, Bernard Pécoul, Lembit Rägo, Arash Rashidian, Dennis Ross-Degnan, Peter N Stephens, Yot Teerawattananon, Ellen F M 't Hoen, Anita K Wagner, Prashant Yadav, Michael R Reich
No abstract text is available yet for this article.
November 4, 2016: Lancet
https://www.readbyqxmd.com/read/27816061/political-economy-challenges-in-nutrition
#2
Yarlini Balarajan, Michael R Reich
BACKGROUND: Historically, implementing nutrition policy has confronted persistent obstacles, with many of these obstacles arising from political economy sources. While there has been increased global policy attention to improving nutrition in recent years, the difficulty of translating this policy momentum into results remains. DISCUSSION: We present key political economy themes emanating from the political economy of nutrition literature. Together, these interrelated themes create a complex web of obstacles to moving nutrition policy forward...
November 5, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27786572/haplo-cord-transplant-hla-matching-determines-graft-dominance
#3
Koen van Besien, Nebu Koshy, Usama Gergis, Sebastian Mayer, Melissa Cushing, Hannah Rennert, Ronit Reich-Slotky, Tomer Mark, Roger Pearse, Adriana Rossi, Adrienne Phillips, Liljana Vasovic, Rosanna Ferrante, Yen-Michael Hsu, Tsiporah Shore
No abstract text is available yet for this article.
October 27, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27771325/latent-class-analysis-reveals-clinically-relevant-atopy-phenotypes-in-2-birth-cohorts
#4
Alexander J Hose, Martin Depner, Sabina Illi, Susanne Lau, Thomas Keil, Ulrich Wahn, Oliver Fuchs, Petra Ina Pfefferle, Elisabeth Schmaußer-Hechfellner, Jon Genuneit, Roger Lauener, Anne M Karvonen, Caroline Roduit, Jean-Charles Dalphin, Josef Riedler, Juha Pekkanen, Erika von Mutius, Markus J Ege
BACKGROUND: Phenotypes of childhood-onset asthma are characterized by distinct trajectories and functional features. For atopy, definition of phenotypes during childhood is less clear. OBJECTIVE: We sought to define phenotypes of atopic sensitization over the first 6 years of life using a latent class analysis (LCA) integrating 3 dimensions of atopy: allergen specificity, time course, and levels of specific IgE (sIgE). METHODS: Phenotypes were defined by means of LCA in 680 children of the Multizentrische Allergiestudie (MAS) and 766 children of the Protection against allergy: Study in Rural Environments (PASTURE) birth cohorts and compared with classical nondisjunctive definitions of seasonal, perennial, and food sensitization with respect to atopic diseases and lung function...
October 19, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27744425/german-neurology-and-the-third-reich
#5
Michael Martin, Heiner Fangerau, Axel Karenberg
BACKGROUND: This paper summarizes the current state of research into the role of German neurology during National Socialism (NS) on the basis of extensive secondary literature and key original sources. SUMMARY: As early as 1933, many neurologists and neuroscientists who had been branded as 'non-Aryan' and/or politically persecuted had to leave Germany, were driven to suicide or killed in concentration camps. Two years later, the regulatory merger with the Psychiatrists' Association caused the cautious attempts of the institutionally hampered discipline for autonomy to end in complete failure...
2016: European Neurology
https://www.readbyqxmd.com/read/27738143/positive-biodiversity-productivity-relationship-predominant-in-global-forests
#6
Jingjing Liang, Thomas W Crowther, Nicolas Picard, Susan Wiser, Mo Zhou, Giorgio Alberti, Ernst-Detlef Schulze, A David McGuire, Fabio Bozzato, Hans Pretzsch, Sergio de-Miguel, Alain Paquette, Bruno Hérault, Michael Scherer-Lorenzen, Christopher B Barrett, Henry B Glick, Geerten M Hengeveld, Gert-Jan Nabuurs, Sebastian Pfautsch, Helder Viana, Alexander C Vibrans, Christian Ammer, Peter Schall, David Verbyla, Nadja Tchebakova, Markus Fischer, James V Watson, Han Y H Chen, Xiangdong Lei, Mart-Jan Schelhaas, Huicui Lu, Damiano Gianelle, Elena I Parfenova, Christian Salas, Eungul Lee, Boknam Lee, Hyun Seok Kim, Helge Bruelheide, David A Coomes, Daniel Piotto, Terry Sunderland, Bernhard Schmid, Sylvie Gourlet-Fleury, Bonaventure Sonké, Rebecca Tavani, Jun Zhu, Susanne Brandl, Jordi Vayreda, Fumiaki Kitahara, Eric B Searle, Victor J Neldner, Michael R Ngugi, Christopher Baraloto, Lorenzo Frizzera, Radomir Bałazy, Jacek Oleksyn, Tomasz Zawiła-Niedźwiecki, Olivier Bouriaud, Filippo Bussotti, Leena Finér, Bogdan Jaroszewicz, Tommaso Jucker, Fernando Valladares, Andrzej M Jagodzinski, Pablo L Peri, Christelle Gonmadje, William Marthy, Timothy O'Brien, Emanuel H Martin, Andrew R Marshall, Francesco Rovero, Robert Bitariho, Pascal A Niklaus, Patricia Alvarez-Loayza, Nurdin Chamuya, Renato Valencia, Frédéric Mortier, Verginia Wortel, Nestor L Engone-Obiang, Leandro V Ferreira, David E Odeke, Rodolfo M Vasquez, Simon L Lewis, Peter B Reich
The biodiversity-productivity relationship (BPR) is foundational to our understanding of the global extinction crisis and its impacts on ecosystem functioning. Understanding BPR is critical for the accurate valuation and effective conservation of biodiversity. Using ground-sourced data from 777,126 permanent plots, spanning 44 countries and most terrestrial biomes, we reveal a globally consistent positive concave-down BPR, showing that continued biodiversity loss would result in an accelerating decline in forest productivity worldwide...
October 14, 2016: Science
https://www.readbyqxmd.com/read/27665707/evaluating-the-performance-of-infectious-disease-forecasts-a-comparison-of-climate-driven-and-seasonal-dengue-forecasts-for-mexico
#7
Michael A Johansson, Nicholas G Reich, Aditi Hota, John S Brownstein, Mauricio Santillana
Dengue viruses, which infect millions of people per year worldwide, cause large epidemics that strain healthcare systems. Despite diverse efforts to develop forecasting tools including autoregressive time series, climate-driven statistical, and mechanistic biological models, little work has been done to understand the contribution of different components to improved prediction. We developed a framework to assess and compare dengue forecasts produced from different types of models and evaluated the performance of seasonal autoregressive models with and without climate variables for forecasting dengue incidence in Mexico...
September 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27663079/secukinumab-is-superior-to-ustekinumab-in-clearing-skin-of-subjects-with-moderate-to-severe-plaque-psoriasis-up-to-1%C3%A2-year-results-from-the-clear-study
#8
Andrew Blauvelt, Kristian Reich, Tsen-Fang Tsai, Stephen Tyring, Francisco Vanaclocha, Külli Kingo, Michael Ziv, Andreas Pinter, Ronald Vender, Sophie Hugot, Ruquan You, Marina Milutinovic, Diamant Thaçi
BACKGROUND: Secukinumab demonstrated superior efficacy to ustekinumab at week 4 and week 16 of the CLEAR study, with comparable safety, in subjects with moderate-to-severe plaque psoriasis. OBJECTIVE: To compare the efficacy and safety of secukinumab and ustekinumab use over 52 weeks. METHODS: Analysis of 52-week data from CLEAR, a randomized, double-blind, phase 3b study. RESULTS: Among 676 randomized subjects, secukinumab demonstrated superiority to ustekinumab at week 52 in the proportion of subjects with ≥90% improvement in Psoriasis Area and Severity Index (PASI 90) (76% vs 61% [P < ...
September 20, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27648638/lysophosphatidic-acids-and-autotaxin-in-retinal-vein-occlusion
#9
Ivanka Dacheva, Christoph Ullmer, Karolina Ceglowska, Everson Nogoceke, Guido Hartmann, Stephan Müller, Robert Rejdak, Katarzyna Nowomiejska, Michael Reich, Matthias Nobl, Tamer Tandogan, Florian T A Kretz, Gerd U Auffarth, Michael J Koss
PURPOSE: To analyze the levels of lysophosphatidic acids (LPAs) and autotaxin (ATX) in undiluted vitreous of untreated patients with retinal vein occlusion (RVO). METHODS: Sixty-four vitreous samples (40 RVO, 24 controls with idiopathic floaters) were analyzed in this retrospective case series using LC/MS for LPAs 16:0, 18:0, 18:1, 20:4, and ELISA kits or Luminex technology for ATX, angiopoetin-1 (ANG-1), interleukin-6 (IL-6), interleukin-7 (IL-7), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), pigment epithelium-derived factor (PEDF), and vascular endothelial growth factor (VEGF)...
December 2016: Retina
https://www.readbyqxmd.com/read/27516608/team-training-in-the-perioperative-arena-a-methodology-for-implementation-and-auditing-behavior
#10
Amanda J Rhee, Yessenia Valentin-Salgado, David Eshak, David Feldman, Pat Kischak, David L Reich, Vicki LoPachin, Michael Brodman
Preventable medical errors in the operating room are most often caused by ineffective communication and suboptimal team dynamics. TeamSTEPPS is a government-funded, evidence-based program that provides tools and education to improve teamwork in medicine. The study hospital implemented TeamSTEPPS in the operating room and merged the program with a surgical safety checklist. Audits were performed to collect both quantitative and qualitative information on time out (brief) and debrief conversations, using a standardized audit tool...
August 10, 2016: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/27506672/transluminal-angioplasty-and-stenting-versus-conservative-treatment-in-patients-with-symptomatic-basilar-artery-stenosis-perspective-for-future-clinical-trials
#11
Ilko L Maier, André Karch, Christina Lipke, Daniel Behme, Anastasios Mpotsaris, Christoph Kabbasch, Thomas Liebig, Andrea Faymonville, Arno Reich, Omid Nikoubashman, Jan-Hendrik Buhk, Patrick von Schoenfeld, Werner Weber, Rafael T Mikolajczyk, Mathias Bähr, Michael Knauth, Kai Kallenberg, Jan Liman
PURPOSE: Two recent randomized controlled trials (RCT) consistently showed superiority of aggressive medical treatment versus percutaneous transluminal angioplasty and stenting (PTAS) in patients with intracranial artery stenosis. Patients with symptomatic basilar stenosis have a higher long-term risk of recurrent stroke compared to patients with anterior circulation stenosis but no study has specifically focused on the role of PTAS in this subgroup. The aim of our study was to investigate the subgroup of patients with symptomatic basilar artery stenosis to find evidence for the feasibility of a future clinical trial...
August 9, 2016: Clinical Neuroradiology
https://www.readbyqxmd.com/read/27479754/single-shot-diffraction-data-from-the-mimivirus-particle-using-an-x-ray-free-electron-laser
#12
COMMENT
Tomas Ekeberg, Martin Svenda, M Marvin Seibert, Chantal Abergel, Filipe R N C Maia, Virginie Seltzer, Daniel P DePonte, Andrew Aquila, Jakob Andreasson, Bianca Iwan, Olof Jönsson, Daniel Westphal, Duško Odić, Inger Andersson, Anton Barty, Meng Liang, Andrew V Martin, Lars Gumprecht, Holger Fleckenstein, Saša Bajt, Miriam Barthelmess, Nicola Coppola, Jean-Michel Claverie, N Duane Loh, Christoph Bostedt, John D Bozek, Jacek Krzywinski, Marc Messerschmidt, Michael J Bogan, Christina Y Hampton, Raymond G Sierra, Matthias Frank, Robert L Shoeman, Lukas Lomb, Lutz Foucar, Sascha W Epp, Daniel Rolles, Artem Rudenko, Robert Hartmann, Andreas Hartmann, Nils Kimmel, Peter Holl, Georg Weidenspointner, Benedikt Rudek, Benjamin Erk, Stephan Kassemeyer, Ilme Schlichting, Lothar Strüder, Joachim Ullrich, Carlo Schmidt, Faton Krasniqi, Günter Hauser, Christian Reich, Heike Soltau, Sebastian Schorb, Helmut Hirsemann, Cornelia Wunderer, Heinz Graafsma, Henry Chapman, Janos Hajdu
Free-electron lasers (FEL) hold the potential to revolutionize structural biology by producing X-ray pules short enough to outrun radiation damage, thus allowing imaging of biological samples without the limitation from radiation damage. Thus, a major part of the scientific case for the first FELs was three-dimensional (3D) reconstruction of non-crystalline biological objects. In a recent publication we demonstrated the first 3D reconstruction of a biological object from an X-ray FEL using this technique. The sample was the giant Mimivirus, which is one of the largest known viruses with a diameter of 450 nm...
2016: Scientific Data
https://www.readbyqxmd.com/read/27459054/genomic-insights-into-the-origin-of-farming-in-the-ancient-near-east
#13
Iosif Lazaridis, Dani Nadel, Gary Rollefson, Deborah C Merrett, Nadin Rohland, Swapan Mallick, Daniel Fernandes, Mario Novak, Beatriz Gamarra, Kendra Sirak, Sarah Connell, Kristin Stewardson, Eadaoin Harney, Qiaomei Fu, Gloria Gonzalez-Fortes, Eppie R Jones, Songül Alpaslan Roodenberg, György Lengyel, Fanny Bocquentin, Boris Gasparian, Janet M Monge, Michael Gregg, Vered Eshed, Ahuva-Sivan Mizrahi, Christopher Meiklejohn, Fokke Gerritsen, Luminita Bejenaru, Matthias Blüher, Archie Campbell, Gianpiero Cavalleri, David Comas, Philippe Froguel, Edmund Gilbert, Shona M Kerr, Peter Kovacs, Johannes Krause, Darren McGettigan, Michael Merrigan, D Andrew Merriwether, Seamus O'Reilly, Martin B Richards, Ornella Semino, Michel Shamoon-Pour, Gheorghe Stefanescu, Michael Stumvoll, Anke Tönjes, Antonio Torroni, James F Wilson, Loic Yengo, Nelli A Hovhannisyan, Nick Patterson, Ron Pinhasi, David Reich
We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time between ~12,000 and 1,400 bc, from Natufian hunter-gatherers to Bronze Age farmers. We show that the earliest populations of the Near East derived around half their ancestry from a 'Basal Eurasian' lineage that had little if any Neanderthal admixture and that separated from other non-African lineages before their separation from each other. The first farmers of the southern Levant (Israel and Jordan) and Zagros Mountains (Iran) were strongly genetically differentiated, and each descended from local hunter-gatherers...
August 25, 2016: Nature
https://www.readbyqxmd.com/read/27380040/comparison-of-automated-brain-volumetry-methods-with-stereology-in-children-aged-2-to-3%C3%A2-years
#14
Kristina N Mayer, Beatrice Latal, Walter Knirsch, Ianina Scheer, Michael von Rhein, Bettina Reich, Jürgen Bauer, Kerstin Gummel, Neil Roberts, Ruth O'Gorman Tuura
INTRODUCTION: The accurate and precise measurement of brain volumes in young children is important for early identification of children with reduced brain volumes and an increased risk for neurodevelopmental impairment. Brain volumes can be measured from cerebral MRI (cMRI), but most neuroimaging tools used for cerebral segmentation and volumetry were developed for use in adults and have not been validated in infants or young children. Here, we investigate the feasibility and accuracy of three automated software methods (i...
September 2016: Neuroradiology
https://www.readbyqxmd.com/read/27373151/neucode-proteomics-reveals-bap1-regulation-of-metabolism
#15
Joshua M Baughman, Christopher M Rose, Ganesh Kolumam, Joshua D Webster, Emily M Wilkerson, Anna E Merrill, Timothy W Rhoads, Rajkumar Noubade, Paula Katavolos, Justin Lesch, Donald S Stapleton, Mary E Rabaglia, Kathy L Schueler, Raymond Asuncion, Melanie Domeyer, Jose Zavala-Solorio, Michael Reich, Jason DeVoss, Mark P Keller, Alan D Attie, Alexander S Hebert, Michael S Westphall, Joshua J Coon, Donald S Kirkpatrick, Anwesha Dey
We introduce neutron-encoded (NeuCode) amino acid labeling of mice as a strategy for multiplexed proteomic analysis in vivo. Using NeuCode, we characterize an inducible knockout mouse model of Bap1, a tumor suppressor and deubiquitinase whose in vivo roles outside of cancer are not well established. NeuCode proteomics revealed altered metabolic pathways following Bap1 deletion, including profound elevation of cholesterol biosynthetic machinery coincident with reduced expression of gluconeogenic and lipid homeostasis proteins in liver...
July 12, 2016: Cell Reports
https://www.readbyqxmd.com/read/27362861/proteomic-analysis-of-vitreous-humor-in-retinal-vein-occlusion
#16
Michael Reich, Ivanka Dacheva, Matthias Nobl, Justyna Siwy, Joost P Schanstra, William Mullen, Frank H J Koch, Jürgen Kopitz, Florian T A Kretz, Gerd U Auffarth, Michael J Koss
PURPOSE: To analyze the protein profile of human vitreous of untreated patients with retinal vein occlusion (RVO). METHODS: Sixty-eight vitreous humor (VH) samples (44 from patients with treatment naïve RVO, 24 controls with idiopathic floaters) were analyzed in this clinical-experimental study using capillary electrophoresis coupled to mass spectrometer and tandem mass spectrometry. To define potential candidate protein markers of RVO, proteomic analysis was performed on RVO patients (n = 30) and compared with controls (n = 16)...
2016: PloS One
https://www.readbyqxmd.com/read/27333804/cord-blood-chimerism-and-relapse-after-haplo-cord-transplantation
#17
Koen van Besien, Nebu Koshy, Usama Gergis, Sebastian Mayer, Melissa Cushing, Hannah Rennert, Ronit Reich-Slotky, Tomer Mark, Roger Pearse, Adriana Rossi, Adrienne Phillips, Liljana Vasovic, Rosanna Ferrante, Yen-Michael Hsu, Tsiporah Shore
Haplo-cord stem cell transplantation combines the infusion of CD34 selected hematopoietic progenitors from a haplo-identical donor with an umbilical cord blood (UCB) graft from an unrelated donor and allows faster count recovery, with low rates of disease recurrence and chronic graft-versus-host disease (GVHD). But the contribution of the umbilical cord blood graft to long-term transplant outcome remains unclear. We analyzed 39 recipients of haplo-cord transplants with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), engrafted and in remission at 2 months...
June 23, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27284963/convergent-acclimation-of-leaf-photosynthesis-and-respiration-to-prevailing-ambient-temperatures-under-current-and-warmer-climates-in-eucalyptus-tereticornis
#18
Michael J Aspinwall, John E Drake, Courtney Campany, Angelica Vårhammar, Oula Ghannoum, David T Tissue, Peter B Reich, Mark G Tjoelker
Understanding physiological acclimation of photosynthesis and respiration is important in elucidating the metabolic performance of trees in a changing climate. Does physiological acclimation to climate warming mirror acclimation to seasonal temperature changes? We grew Eucalyptus tereticornis trees in the field for 14 months inside 9-m tall whole-tree chambers tracking ambient air temperature (Tair ) or ambient Tair  + 3°C (i.e. 'warmed'). We measured light- and CO2 -saturated net photosynthesis (Amax ) and night-time dark respiration (R) each month at 25°C to quantify acclimation...
October 2016: New Phytologist
https://www.readbyqxmd.com/read/27281232/protection-of-vine-plants-against-esca-disease-by-breathable-electrospun-antifungal-nonwovens
#19
Viola Buchholz, Melanie Molnar, Hui Wang, Steffen Reich, Seema Agarwal, Michael Fischer, Andreas Greiner
The harmful Esca disease in vine plants caused by wood-inhabiting fungi including Phaeomoniella chlamydospora (Pch) is spreading all across the world. This disease leads to poor vine crops and a slow decline or to a sudden dieback of the vine plants. The pruning wounds of vine plants are the main entry point for Pch. While model experiments with aerosol particles recommend electrospun nonwovens as a suitable barrier to block Pch, tests with living spores show clearly that only electrospun fibrous nonwovens do not prevent Pch invasion...
September 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27274072/characterizing-treatment-pathways-at-scale-using-the-ohdsi-network
#20
George Hripcsak, Patrick B Ryan, Jon D Duke, Nigam H Shah, Rae Woong Park, Vojtech Huser, Marc A Suchard, Martijn J Schuemie, Frank J DeFalco, Adler Perotte, Juan M Banda, Christian G Reich, Lisa M Schilling, Michael E Matheny, Daniella Meeker, Nicole Pratt, David Madigan
Observational research promises to complement experimental research by providing large, diverse populations that would be infeasible for an experiment. Observational research can test its own clinical hypotheses, and observational studies also can contribute to the design of experiments and inform the generalizability of experimental research. Understanding the diversity of populations and the variance in care is one component. In this study, the Observational Health Data Sciences and Informatics (OHDSI) collaboration created an international data network with 11 data sources from four countries, including electronic health records and administrative claims data on 250 million patients...
July 5, 2016: Proceedings of the National Academy of Sciences of the United States of America
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