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JOURNAL ARTICLE
Abiodun O Oluyomi, Sophie C Schneider, Catherine Christian, Juan M Alvarez, Orri Smárason, Wayne K Goodman, Eric A Storch
Obsessive-compulsive disorder is an impairing psychiatric condition affecting 1-2% of adults and youth. Cognitive-behavioral therapy with exposure and response prevention (CBT) is an efficacious intervention but requires specialty training and access is often limited. While certain factors are associated with treatment access, one key barrier that has not been explored is the geographic availability of OCD treatment providers. Using integrated geographically-referenced data, we examined the geographic distribution of OCD CBT specialty providers across the state of Texas, with particular attention to the relationship to neighborhood socioeconomic disadvantage, insurance status, and rural versus urban status...
July 2023: Journal of Obsessive-compulsive and related Disorders
#22
RANDOMIZED CONTROLLED TRIAL
Chris P Gale, Deborah D Stocken, Suleman Aktaa, Catherine Reynolds, Rachael Gilberts, David Brieger, Kathryn Carruthers, Derek P Chew, Shaun G Goodman, Catherine Fernandez, Linda D Sharples, Andrew T Yan, Keith Fox
OBJECTIVE: To determine the effectiveness of risk stratification using the Global Registry of Acute Coronary Events (GRACE) risk score (GRS) for patients presenting to hospital with suspected non-ST elevation acute coronary syndrome. DESIGN: Parallel group cluster randomised controlled trial. SETTING: Patients presenting with suspected non-ST elevation acute coronary syndrome to 42 hospitals in England between 9 March 2017 and 30 December 2019...
June 14, 2023: BMJ: British Medical Journal
#23
JOURNAL ARTICLE
Claire R Burbick, Virginia R Fajt, Erin Frey, Heather Fritz, Laura B Goodman, Catherine Lorenz, Brian V Lubbers, Edith Marshall, Shelley C Rankin, Marissa Silva
Antibiograms are important tools for antimicrobial stewardship that are often underutilized in veterinary medicine. Antibiograms summarize cumulative antimicrobial susceptibility testing (AST) data for specific pathogens over a defined time period; in veterinary medicine, they are often stratified by host species and site of infection. They can aid practitioners with empiric therapy choices and assessment of antimicrobial resistance trends within a population in support of one-health goals for antimicrobial stewardship...
June 19, 2023: American Journal of Veterinary Research
#24
JOURNAL ARTICLE
Matti Cervin, Andrew G Guzick, Jane Clinger, Eleanor E A Smith, Isabel A Draper, Wayne K Goodman, Marijn Lijffijt, Nicholas Murphy, Catherine E Rast, Sophie C Schneider, Eric A Storch
BACKGROUND: Misophonia is characterized by intense emotional reactions to specific sounds or visual stimuli and typically onsets during childhood. An obstacle for research and clinical practice is that no comprehensively evaluated measures for pediatric misophonia exist. METHODS: In a sample of 102 youth meeting the proposed diagnostic criteria of misophonia, we evaluated the child and parent-proxy versions of the self-reported Misophonia Assessment Questionnaire (MAQ; assessing broad aspects of misophonia) and the child version of the Amsterdam Misophonia Scale (A-MISO-S; assessing misophonia severity)...
May 30, 2023: Journal of Affective Disorders
#25
JOURNAL ARTICLE
Claudia A Alvarez, Areg Grigorian, Lourdes Swentek, Theresa Chin, Yigit Guner, Laura Goodman, Catherine Kuza, Jeffry Nahmias
BACKGROUND: Over 20% of United States adolescents are obese. A thicker layer of subcutaneous adiposity might provide a protective "armor" layer against penetrating wounds. We hypothesized that adolescents with obesity presenting after isolated thoracic and abdominal penetrating trauma have lower rates of severe injury and mortality than adolescents without obesity. METHODS: The 2017-2019 Trauma Quality Improvement Program database was queried for patients between 12 and 17 years old presenting with knife or gunshot wounds...
May 5, 2023: American Surgeon
#26
JOURNAL ARTICLE
HyoJong Jang, David P Goodman, Jessica Ausborn, Catherine R von Reyn
Spatially invariant feature detection is a property of many visual systems that rely on visual information provided by two eyes. However, how information across both eyes is integrated for invariant feature detection is not fully understood. Here we investigate spatial invariance of looming responses in descending neurons (DNs) of Drosophila melanogaster. We find multiple looming responsive DNs integrate looming information across both eyes, even though their dendrites are restricted to a single visual hemisphere...
April 17, 2023: Journal of Experimental Biology
#27
JOURNAL ARTICLE
Andy Bradshaw, Sophia Ostler, Claire Goodman, Izabele Batkovskyte, Clare Ellis-Smith, India Tunnard, Anna E Bone, Stephen Barclay, Martin Vernon, Irene J Higginson, Catherine J Evans, Katherine E Sleeman
INTRODUCTION: Little consideration has been given to how the provision of palliative and end-of-life care in care homes was affected by COVID-19. The aims of this study were to: (i) investigate the response of UK care homes in meeting the rapidly increasing need for palliative and end-of-life care during the COVID-19 pandemic and (ii) propose policy recommendations for strengthening the provision of palliative and end-of-life care within care homes. MATERIALS AND METHODS: A mixed methods observational study was conducted, which incorporated (i) an online cross-sectional survey of UK care homes and (ii) qualitative interviews with care home practitioners...
2023: Frontiers in Public Health
#28
JOURNAL ARTICLE
Somin Lee, Sarita S Deshpande, Edward M Merricks, Emily Schlafly, Robert Goodman, Guy M McKhann, Emad N Eskandar, Joseph R Madsen, Sydney S Cash, Michel J A M van Putten, Catherine A Schevon, Wim van Drongelen
The electrographic manifestation of neural activity can reflect the relationship between the faster action potentials of individual neurons and the slower fluctuations of the local field potential (LFP). This relationship is typically examined in the temporal domain using the spike-triggered average. In this study, we add a spatial component to this relationship. Here we first derive a theoretical model of the spike-LFP relationship across a macroelectrode. This mathematical derivation showed a special symmetry in the spike-LFP relationship wherein a sinc function in the temporal domain predicts a sinc function in the spatial domain...
March 25, 2023: Communications Biology
#29
JOURNAL ARTICLE
Emily A Knapp, Amii M Kress, Corette B Parker, Grier P Page, Kristen McArthur, Kennedy K Gachigi, Akram N Alshawabkeh, Judy L Aschner, Theresa M Bastain, Carrie V Breton, Casper G Bendixsen, Patricia A Brennan, Nicole R Bush, Claudia Buss, Carlos A Camargo, Diane Catellier, José F Cordero, Lisa Croen, Dana Dabelea, Sean Deoni, Viren D'Sa, Cristiane S Duarte, Anne L Dunlop, Amy J Elliott, Shohreh F Farzan, Assiamira Ferrara, Jody M Ganiban, James E Gern, Angelo P Giardino, Nissa R Towe-Goodman, Diane R Gold, Rima Habre, Ghassan B Hamra, Tina Hartert, Julie B Herbstman, Irva Hertz-Picciotto, Alison E Hipwell, Margaret R Karagas, Catherine J Karr, Kate Keenan, Jean M Kerver, Daphne Koinis-Mitchell, Bryan Lau, Barry M Lester, Leslie D Leve, Bennett Leventhal, Kaja Z LeWinn, Johnnye Lewis, Augusto A Litonjua, Kristen Lyall, Juliette C Madan, Cindy T McEvoy, Monica McGrath, John D Meeker, Rachel L Miller, Rachel Morello-Frosch, Jenae M Neiderhiser, Thomas G O'Connor, Emily Oken, Michael O'Shea, Nigel Paneth, Christina A Porucznik, Sheela Sathyanarayana, Susan L Schantz, Eliot R Spindel, Joseph B Stanford, Annemarie Stroustrup, Susan L Teitelbaum, Leonardo Trasande, Heather Volk, Pathik D Wadhwa, Scott T Weiss, Tracey J Woodruff, Rosalind J Wright, Qi Zhao, Lisa P Jacobson, On Behalf Of Program Collaborators For Environmental Influences On Child Health Outcomes
The Environmental influences on Child Health Outcomes (ECHO)-wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve children's health in the United States. The EWC harmonizes extant data and collects new data using a standardized protocol, the ECHO-wide Cohort data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but the frequency and timing of the visits vary across cohorts...
March 24, 2023: American Journal of Epidemiology
#30
JOURNAL ARTICLE
Martin Köbel, Eun-Young Kang, Ashley Weir, Peter F Rambau, Cheng-Han Lee, Gregg S Nelson, Prafull Ghatage, Nicola S Meagher, Marjorie J Riggan, Jennifer Alsop, Michael S Anglesio, Matthias W Beckmann, Christiani Bisinotto, Michelle Boisen, Jessica Boros, Alison H Brand, Angela Brooks-Wilson, Michael E Carney, Penny Coulson, Madeleine Courtney-Brooks, Kara L Cushing-Haugen, Cezary Cybulski, Suha Deen, Mona A El-Bahrawy, Esther Elishaev, Ramona Erber, Sian Fereday, Anna Fischer, Simon A Gayther, Arantzazu Barquin-Garcia, Aleksandra Gentry-Maharaj, C Blake Gilks, Helena Gronwald, Marcel Grube, Paul R Harnett, Holly R Harris, Andreas D Hartkopf, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y Hernandez, Yajue Huang, Anna Jakubowska, Mercedes Jimenez-Linan, Michael E Jones, Catherine J Kennedy, Tomasz Kluz, Jennifer M Koziak, Jaime Lesnock, Jenny Lester, Jan Lubiński, Teri A Longacre, Maria Lycke, Constantina Mateoiu, Bryan M McCauley, Valerie McGuire, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Paz-Ares, Teresa Ramón Y Cajal, Joseph H Rothstein, Matthias Ruebner, Minouk J Schoemaker, Mitul Shah, Raghwa Sharma, Mark E Sherman, Yurii B Shvetsov, Naveena Singh, Helen Steed, Sarah J Storr, Aline Talhouk, Nadia Traficante, Chen Wang, Alice S Whittemore, Martin Widschwendter, Lynne R Wilkens, Stacey J Winham, Javier Benitez, Andrew Berchuck, David D Bowtell, Francisco J Candido Dos Reis, Ian Campbell, Linda S Cook, Anna DeFazio, Jennifer A Doherty, Peter A Fasching, Renée T Fortner, María J García, Marc T Goodman, Ellen L Goode, Jacek Gronwald, David G Huntsman, Beth Y Karlan, Linda E Kelemen, Stefan Kommoss, Nhu D Le, Stewart G Martin, Usha Menon, Francesmary Modugno, Paul Dp Pharoah, Joellen M Schildkraut, Weiva Sieh, Annette Staebler, Karin Sundfeldt, Anthony J Swerdlow, Susan J Ramus, James D Brenton
Our objective was to test whether p53 expression status is associated with survival for women diagnosed with the most common ovarian carcinoma histotypes (high-grade serous carcinoma [HGSC], endometrioid carcinoma [EC], and clear cell carcinoma [CCC]) using a large multi-institutional cohort from the Ovarian Tumor Tissue Analysis (OTTA) consortium. p53 expression was assessed on 6,678 cases represented on tissue microarrays from 25 participating OTTA study sites using a previously validated immunohistochemical (IHC) assay as a surrogate for the presence and functional effect of TP53 mutations...
May 2023: Journal of Pathology. Clinical Research
#31
JOURNAL ARTICLE
Susan Bridgewater, Michael A Shepherd, Jill Dawson, Pamela Richards, Christine Silverthorne, Mwidimi Ndosi, Celia Almeida, Rachel J Black, Jonathan T L Cheah, Emma Dures, Nilasha Ghosh, Elizabeth A Hoon, Suellen Lyne, Iris Navarro-Millan, Diyu Pearce-Fisher, Carlee Ruediger, Joanna Tieu, Kevin Yip, Sarah L Mackie, Susan Goodman, Catherine Hill, Joanna C Robson
OBJECTIVES: Glucocorticoids (GCs) ('steroids') are used to treat rheumatic diseases but adverse effects are common. We aimed to explore the impact of GC therapy on health-related quality of life (HRQoL), to inform the development of a treatment-specific patient-reported outcome measure (PROM) for use in clinical trials and practice. METHODS: Semi-structured qualitative interviews were conducted with patients from the UK, USA and Australia, treated for a rheumatic condition with GCs in the last two years...
February 25, 2023: Rheumatology
#32
JOURNAL ARTICLE
Jessica Julia Carne King, Timothy Powell-Jackson, James Hargreaves, Christina Makungu, Catherine Goodman
BACKGROUND: Poor quality of care, including overprovision (unnecessary care) is a global health concern. Greater provider effort has been shown to increase the likelihood of correct treatment, but its relationship with overprovision is less clear. Providers who make more effort may give more treatment overall, both correct and unnecessary, or may have lower rates of overprovision; we test which is true in the Tanzanian private health sector. METHODS: Standardised patients visited 227 private-for-profit and faith-based facilities in Tanzania, presenting with symptoms of asthma and TB...
February 23, 2023: BMC Health Services Research
#33
JOURNAL ARTICLE
Greg J Goodman, Cara B McDonald, Adrian Lim, Catherine E Porter, Anand K Deva, Mark Magnusson, Anita Patel, Sarah Hart, Peter Callan, Alice Rudd, Stefania Roberts, Katy Wallace, Philip Bekhor, Michael Clague, Linda Williams, Niamh Corduff, Nina Wines, Firas Al-Niaimi, Sabrina G Fabi, Howard M Studniberg, Saxon Smith, Angelo Tsirbas, Sean Arendse, Antoinette Ciconte, Terence Poon
BACKGROUND: The pathogenesis of delayed onset tissue nodules (DTNs) due to hyaluronic acid (HA) injections is uncertain. OBJECTIVES: To formulate a rational theory for DTN development and their avoidance and treatment. METHODS: A multi-disciplinary and multi country DTN consensus panel was established with 20 questions posed and consensus sought. Consensus was set at 75% agreement. RESULTS: Consensus was reached in 16/20 questions regarding the pathogenesis of DTNs forming the basis of a classification and treatment guide...
February 10, 2023: Aesthetic Surgery Journal
#34
JOURNAL ARTICLE
Rohit Loomba, Daniel Q Huang, Arun J Sanyal, Quentin Mark Anstee, Michael Trauner, Eric J Lawitz, Dora Ding, Lily Ma, Catherine Jia, Andrew Billin, Ryan S Huss, Chuhan Chung, Zachary Goodman, Vincent Wai-Sun Wong, Takeshi Okanoue, Manuel Romero-Gómez, Manal F Abdelmalek, Andrew Muir, Nezam Afdhal, Jaime Bosch, Stephen Harrison, Zobair M Younossi, Robert P Myers
OBJECTIVE: In retrospective studies, liver stiffness (LS) by vibration-controlled transient elastography (VCTE) is associated with the risk of liver decompensation in patients with non-alcoholic steatohepatitis (NASH), but prospective data in biopsy-confirmed cohorts with advanced fibrosis are limited. We aimed to establish thresholds for LS by VCTE that predict progression to cirrhosis among patients with bridging fibrosis and hepatic decompensation among patients with cirrhosis due to NASH...
March 2023: Gut
#35
JOURNAL ARTICLE
Eun-Young Kang, Ashley Weir, Nicola S Meagher, Kyo Farrington, Gregg S Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J Riggan, Adelyn Bolithon, Gordana Popovic, Betty Leung, Katrina Tang, Neil Lambie, Joshua Millstein, Jennifer Alsop, Michael S Anglesio, Beyhan Ataseven, Ellen Barlow, Matthias W Beckmann, Jessica Berger, Christiani Bisinotto, Hans Bösmüller, Jessica Boros, Alison H Brand, Angela Brooks-Wilson, Sara Y Brucker, Michael E Carney, Yovanni Casablanca, Alicia Cazorla-Jiménez, Paul A Cohen, Thomas P Conrads, Linda S Cook, Penny Coulson, Madeleine Courtney-Brooks, Daniel W Cramer, Philip Crowe, Julie M Cunningham, Cezary Cybulski, Kathleen M Darcy, Mona A El-Bahrawy, Esther Elishaev, Ramona Erber, Rhonda Farrell, Sian Fereday, Anna Fischer, María J García, Simon A Gayther, Aleksandra Gentry-Maharaj, C Blake Gilks, Marcel Grube, Paul R Harnett, Shariska Petersen Harrington, Philipp Harter, Arndt Hartmann, Jonathan L Hecht, Sebastian Heikaus, Alexander Hein, Florian Heitz, Joy Hendley, Brenda Y Hernandez, Susanna Hernando Polo, Sabine Heublein, Akira Hirasawa, Estrid Høgdall, Claus K Høgdall, Hugo M Horlings, David G Huntsman, Tomasz Huzarski, Andrea Jewell, Mercedes Jimenez-Linan, Michael E Jones, Scott H Kaufmann, Catherine J Kennedy, Dineo Khabele, Felix K F Kommoss, Roy F P M Kruitwagen, Diether Lambrechts, Nhu D Le, Marcin Lener, Jenny Lester, Yee Leung, Anna Linder, Liselore Loverix, Jan Lubiński, Rashna Madan, G Larry Maxwell, Francesmary Modugno, Susan L Neuhausen, Alexander Olawaiye, Siel Olbrecht, Sandra Orsulic, José Palacios, Celeste Leigh Pearce, Malcolm C Pike, Carmel M Quinn, Ganendra Raj Mohan, Cristina Rodríguez-Antona, Matthias Ruebner, Andy Ryan, Stuart G Salfinger, Naoko Sasamoto, Joellen M Schildkraut, Minouk J Schoemaker, Mitul Shah, Raghwa Sharma, Yurii B Shvetsov, Naveena Singh, Gabe S Sonke, Linda Steele, Colin J R Stewart, Karin Sundfeldt, Anthony J Swerdlow, Aline Talhouk, Adeline Tan, Sarah E Taylor, Kathryn L Terry, Aleksandra Tołoczko, Nadia Traficante, Koen K Van de Vijver, Maaike A van der Aa, Toon Van Gorp, Els Van Nieuwenhuysen, Lilian van-Wagensveld, Ignace Vergote, Robert A Vierkant, Chen Wang, Lynne R Wilkens, Stacey J Winham, Anna H Wu, Javier Benitez, Andrew Berchuck, Francisco J Candido Dos Reis, Anna DeFazio, Peter A Fasching, Ellen L Goode, Marc T Goodman, Jacek Gronwald, Beth Y Karlan, Stefan Kommoss, Usha Menon, Hans-Peter Sinn, Annette Staebler, James D Brenton, David D Bowtell, Paul D P Pharoah, Susan J Ramus, Martin Köbel
BACKGROUND: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with survival, but to date no large-scale, histotype-specific validation has been performed. The hypothesis was that high-level amplification of CCNE1 and CCNE1 overexpression, as well as a combination of the two, are linked to shorter overall survival in HGSC...
December 26, 2022: Cancer
#36
JOURNAL ARTICLE
Timothy Chege, Francis Wafula, Eric Tama, Irene Khayoni, Dosila Ogira, Njeri Gitau, Catherine Goodman
BACKGROUND: In most low- and middle-income countries, health facility regulation is fragmented, ineffective and under-resourced. The Kenyan Government piloted an innovative regulatory regime involving Joint Health Inspections (JHI) which synthesized requirements across multiple regulatory agencies; increased inspection frequency; digitized inspection tools; and introduced public display of regulatory results. The pilot significantly improved regulatory compliance. We calculated the costs of the development and implementation of the JHI pilot and modelled the costs of national scale-up in Kenya...
November 14, 2022: BMC Health Services Research
#37
JOURNAL ARTICLE
Ashley Weir, Eun-Young Kang, Nicola S Meagher, Gregg S Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J Riggan, Aleksandra Gentry-Maharaj, Andy Ryan, Naveena Singh, Martin Widschwendter, Jennifer Alsop, Michael S Anglesio, Matthias W Beckmann, Jessica Berger, Christiani Bisinotto, Jessica Boros, Alison H Brand, James D Brenton, Angela Brooks-Wilson, Michael E Carney, Julie M Cunningham, Kara L Cushing-Haugen, Cezary Cybulski, Esther Elishaev, Ramona Erber, Sian Fereday, Anna Fischer, Luis Paz-Ares, Javier Gayarre, Blake C Gilks, Marcel Grube, Paul R Harnett, Holly R Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y Hernandez, Sabine Heublein, Yajue Huang, Tomasz Huzarski, Anna Jakubowska, Mercedes Jimenez-Linan, Catherine J Kennedy, Felix K F Kommoss, Jennifer M Koziak, Bernhard Kraemer, Nhu D Le, Jaime Lesnock, Jenny Lester, Jan Lubiński, Janusz Menkiszak, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Robles-Díaz, Matthias Ruebner, Mitul Shah, Raghwa Sharma, Yurii B Shvetsov, Helen Steed, Aline Talhouk, Sarah E Taylor, Nadia Traficante, Robert A Vierkant, Chen Wang, Lynne R Wilkens, Stacey J Winham, Javier Benitez, Andrew Berchuck, David D Bowtell, Francisco J Candido Dos Reis, Linda S Cook, Anna DeFazio, Jennifer A Doherty, Peter A Fasching, María J García, Ellen L Goode, Marc T Goodman, Jacek Gronwald, David G Huntsman, Beth Y Karlan, Stefan Kommoss, Francesmary Modugno, Joellen M Schildkraut, Hans-Peter Sinn, Annette Staebler, Linda E Kelemen, Caroline E Ford, Usha Menon, Paul D P Pharoah, Martin Köbel, Susan J Ramus
BACKGROUND: Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed to translate prognostic mRNA markers into protein expression assays by immunohistochemistry and validate their survival association in HGSC. METHODS: Two prognostic genes, FOXJ1 and GMNN, were selected based on high-quality antibodies, correlation with protein expression and variation in immunohistochemical scores in a preliminary cohort (n = 134 and n = 80, respectively)...
November 2, 2022: British Journal of Cancer
#38
JOURNAL ARTICLE
Paul T Heath, Eva P Galiza, David Neil Baxter, Marta Boffito, Duncan Browne, Fiona Burns, David R Chadwick, Rebecca Clark, Catherine A Cosgrove, James Galloway, Anna L Goodman, Amardeep Heer, Andrew Higham, Shalini Iyengar, Christopher Jeanes, Philip A Kalra, Christina Kyriakidou, Judy M Bradley, Chigomezgo Munthali, Angela M Minassian, Fiona McGill, Patrick Moore, Imrozia Munsoor, Helen Nicholls, Orod Osanlou, Jonathan Packham, Carol H Pretswell, Alberto San Francisco Ramos, Dinesh Saralaya, Ray P Sheridan, Richard Smith, Roy L Soiza, Pauline A Swift, Emma C Thomson, Jeremy Turner, Marianne Elizabeth Viljoen, Louis Fries, Iksung Cho, Irene McKnight, Greg Glenn, E Joy Rivers, Andreana Robertson, Katia Alves, Kathy Smith, Seth Toback
BACKGROUND: The recombinant protein-based vaccine, NVX-CoV2373, demonstrated 89.7% efficacy against COVID-19 in a phase 3, randomized, observer-blinded, placebo-controlled trial in the United Kingdom. The protocol was amended to include a blinded crossover; data to the end of the placebo-controlled phase are reported. METHODS: Adults aged 18-84 years received two doses of NVX-CoV2373 or placebo (1:1) and were monitored for virologically confirmed mild, moderate, or severe COVID-19 (onset from 7 days after second vaccination)...
October 10, 2022: Clinical Infectious Diseases
#39
JOURNAL ARTICLE
Jennifer T Anger, Kai B Dallas, Catherine Bresee, Amanda M De Hoedt, Kamil E Barbour, Katherine J Hoggatt, Marc T Goodman, Jayoung Kim, Stephen J Freedland
Importance: Interstitial cystitis/bladder pain syndrome (IC/BPS) is an immense burden to both patients and the American healthcare system; it is notoriously difficult to diagnose. Prevalence estimates vary widely (150-fold range in women and >500-fold range in men). Objectives: We aimed to create accurate national IC/BPS prevalence estimates by employing a novel methodology combining a national population-based dataset with individual chart abstraction. Study design: In this epidemiological survey, all living patients, with ≥2 clinic visits from 2016 to 2018 in the Veterans Health Administration, with an ICD-9/10 code for IC/BPS ( n = 9,503) or similar conditions that may represent undiagnosed IC/BPS ( n = 124,331), were identified (other were controls n = 5,069,695)...
2022: Front Pain Res (Lausanne)
#40
JOURNAL ARTICLE
Jeannette M Schenk, Cathee Till, Marian L Neuhouser, Phyllis J Goodman, M Scott Lucia, Ian M Thompson, Catherine M Tangen
BACKGROUND: Multivitamin use is a common health behavior but there is conflicting evidence from prospective studies about whether this behavior increases or decreases prostate cancer (PCa) risk. METHODS: Associations of multivitamin (MVI) use and PCa risk were evaluated using data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Cox proportional hazards models estimated associations of MVI use with risk of total, low- and high-grade PCa. Longitudinal data were used to evaluate screening and biopsy patterns...
September 9, 2022: Cancer Epidemiology, Biomarkers & Prevention
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