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Jessica Cohen

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https://www.readbyqxmd.com/read/29338380/transplantation-of-human-neural-progenitor-cells-reveals-structural-and-functional-improvements-in-the-spastic-han-wistar-rat-model-of-ataxia
#1
Ruslan L Nuryyev, Toni L Uhlendorf, Wesley Tierney, Suren Zatikyan, Oleg Kopyov, Alex Kopyov, Jessica Ochoa, William Van Trigt, Cindy S Malone, Randy W Cohen
The use of regenerative medicine to treat nervous system disorders like ataxia has been proposed to either replace or support degenerating neurons. In this study, we assessed the ability of human neural progenitor cells (hNPCs) to repair and restore the function of dying neurons within the spastic Han-Wistar rat (sHW), a model of ataxia. The sHW rat suffers from neurodegeneration of specific neurons, including cerebellar Purkinje cells and hippocampal CA3 pyramidal cells leading to the observed symptoms of forelimb tremor, hind-leg rigidity, gait abnormality, motor incoordination, and a shortened life span...
November 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29330739/patterns-and-outcomes-of-prescribing-venous-thromboembolism-prophylaxis-in-hospitalized-older-adults-a-retrospective-cohort-study
#2
Mark Goldin, Jessica Cohen, Alex Makhnevich, Colm Mulvany, Meredith Akerman, Liron Sinvani
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in the United States. Hospitalized, medically ill older adults have increased risk; despite guidelines, data suggest suboptimal pharmacologic prophylaxis rates. Factors influencing provider prescribing non-compliance are unclear. We aimed to describe VTE prophylaxis practices and identify risk factors for, and outcomes of, prescribing non-compliance. A retrospective study was conducted of hospitalized adults aged ≥ 75 years, admitted to the medicine service of a large academic tertiary center from May 1, 2014 to June 30, 2015...
January 12, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29318433/amor-and-social-stigma-asd-beliefs-among-immigrant-mexican-parents
#3
Shana R Cohen, Jessica Miguel
This study examined cultural beliefs about ASD and its causes among Mexican-heritage families. In focus group interviews, we asked 25 immigrant parents of children with ASD to identify words they associated with ASD and its causes. Participants free-listed, ranked, and justified their responses. Mixed methods analyses utilized saliency scores to calculate responses. Deductive interview analyses justified participants' responses. Salient responses for ASD perceptions included specific characteristics about the child (e...
January 9, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29310622/entrapment-as-a-mediator-of-suicide-crises
#4
Shuang Li, Zimri S Yaseen, Hae-Joon Kim, Jessica Briggs, Molly Duffy, Anna Frechette-Hagan, Lisa J Cohen, Igor I Galynker
BACKGROUND: Prior research has validated the construct of a suicide crisis syndrome (SCS), a specific psychological state that precedes and may precipitate suicidal behavior. The feeling of entrapment is a central concept of the SCS as well as of several other recent models of suicide. However, its exact relationship with suicidality is not fully understood. In efforts to clarify the exact role of entrapment in the suicidal process, we have examined if entrapment mediates the relationship of other components of the SCS, including ruminative flooding, panic-dissociation, fear of dying and emotional pain, with suicidal ideation (SI) in recently hospitalized psychiatric inpatients...
January 8, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29304947/trading-bankruptcy-for-health-a-discrete-choice-experiment
#5
Mark G Shrime, Milton C Weinstein, James K Hammitt, Jessica L Cohen, Joshua A Salomon
BACKGROUND: Although nearly two-third of bankruptcy in the United States is medical in origin, a common assumption is that individuals facing a potentially lethal disease opt for cure at any cost. This assumption has never been tested, and knowledge of how the American population values a trade-off between cure and bankruptcy is unknown. OBJECTIVES: To determine the relative importance among the general American population of improved health versus improved financial risk protection, and to determine the impact of demographics on these preferences...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29301454/association-between-coping-skills-past-injury-and-hip-pain-and-function-in-adolescent-elite-female-ballet-dancers
#6
Jessica Biernacki, Andrea Stracciolini, Kelsey Griffith, Pierre d'Hemecourt, Michael Owen, Dai Sugimoto
OBJECTIVES: The purpose of this study was to investigate the relationship between coping skills and current hip pain and function scores in ballet dancers. Secondly, we examined the relationship between coping skills and past injuries. Thirdly, we investigated the association between past injuries and current pain and function scores. METHODS: This was a cross-sectional observational study. Twenty-six young elite female dancers (mean age 15.9 years, range 14-17 years) participated...
January 5, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29296769/wnt-ligands-contribute-to-the-immune-response-during-septic-shock-and-amplify-endotoxemia-driven-inflammation-in-mice
#7
Marcela Gatica-Andrades, Dimitrios Vagenas, Jessica Kling, Tam T K Nguyen, Helen Benham, Ranjeny Thomas, Heinrich Körner, Bala Venkatesh, Jeremy Cohen, Antje Blumenthal
Improved understanding of the molecular mechanisms underlying dysregulated inflammatory responses in severe infection and septic shock is urgently needed to improve patient management and identify new therapeutic opportunities. The WNT signaling pathway has been implicated as a novel constituent of the immune response to infection, but its contribution to the host response in septic shock is unknown. Although individual WNT proteins have been ascribed pro- or anti-inflammatory functions, their concerted contributions to inflammation in vivo remain to be clearly defined...
July 11, 2017: Blood Advances
https://www.readbyqxmd.com/read/29285638/the-use-of-online-posts-to-identify-barriers-to-and-facilitators-of-hiv-pre-exposure-prophylaxis-prep-among-men-who-have-sex-with-men-a-comparison-to-a-systematic-review-of-the-peer-reviewed-literature
#8
Alisse Hannaford, Madeleine Lipshie-Williams, Joanna L Starrels, Julia H Arnsten, Jessica Rizzuto, Phillip Cohen, Damon Jacobs, Viraj V Patel
Pre-exposure prophylaxis (PrEP) remains an under-utilized HIV prevention tool among men who have sex with men (MSM). To more comprehensively elucidate barriers and facilitators to PrEP use among US MSM, we conducted a systematic review of peer-reviewed published articles and content analysis of online posts about PrEP. We searched peer-reviewed databases (Medline, Web of Science, Google Scholar) using MESH headings and keywords about PrEP and/or HIV prevention from 2005 to 2015. We included original studies among MSM in the US that reported on barriers, facilitators, or other factors related to PrEP use...
December 28, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29258459/-once-the-delivery-is-done-they-have-finished-a-qualitative-study-of-perspectives-on-postnatal-care-referrals-by-traditional-birth-attendants-in-ebonyi-state-nigeria
#9
Adanna Chukwuma, Chinyere Mbachu, Jessica Cohen, Thomas Bossert, Margaret McConnell
BACKGROUND: While 79% of Nigerian mothers who deliver in facilities receive postnatal care within 48 h of delivery, this is only true for 16% of mothers who deliver outside facilities. Most maternal deaths can be prevented with access to timely and competent health care. Thus, the World Health Organization, International Confederation of Midwives, and International Federation of Gynecology and Obstetrics recommend that unskilled birth attendants be involved in advocacy for skilled care use among mothers...
December 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29207366/differences-in-approaches-and-outcomes-of-defibrillator-lead-implants-between-high-volume-and-low-volume-operators-results-from-the-pacemaker-and-implantable-defibrillator-leads-survival-study-paidless
#10
Zohaib A Shaikh, Jessica A Chung, Daniel J Kersten, Alyssa M Feldman, Wilbur J Asheld, Joseph Germano, Shahidul Islam, Todd J Cohen
OBJECTIVES: The purpose of this study was to investigate the relationship between operator volume and implantable defibrillator lead failure and patient mortality at a single large implanting center. METHODS: This study analyzed the differences between high-volume and low-volume defibrillator implanters in the Pacemaker and Implantable Defibrillator Lead Survival Study ("PAIDLESS") between February 1, 1996 and December 31, 2011 at NYU Winthrop Hospital. "High-volume" was defined as performing ≥500 implants over the study period, while "low-volume" was defined as performing <500 implants...
December 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29181875/integration-of-routine-qa-data-into-mega-analysis-may-improve-quality-and-sensitivity-of-multisite-diffusion-tensor-imaging-studies
#11
Peter Kochunov, Erin W Dickie, Joseph D Viviano, Jessica Turner, Peter B Kingsley, Neda Jahanshad, Paul M Thompson, Meghann C Ryan, Els Fieremans, Dmitry Novikov, Jelle Veraart, Elliot L Hong, Anil K Malhotra, Robert W Buchanan, Sofia Chavez, Aristotle N Voineskos
A novel mega-analytical approach that reduced methodological variance was evaluated using a multisite diffusion tensor imaging (DTI) fractional anisotropy (FA) data by comparing white matter integrity in people with schizophrenia to controls. Methodological variance was reduced through regression of variance captured from quality assurance (QA) and by using Marchenko-Pastur Principal Component Analysis (MP-PCA) denoising. N = 192 (119 patients/73 controls) data sets were collected at three sites equipped with 3T MRI systems: GE MR750, GE HDx, and Siemens Trio...
November 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29167082/disparities-in-health-literacy-and-healthcare-utilization-among-adolescents-and-young-adults-with-chronic-or-end-stage-kidney-disease
#12
Robyn Levine, Karina Javalkar, Meaghan Nazareth, Richard A Faldowski, Maria Diaz-Gonzalez de Ferris, Sarah Cohen, Jessica Cuttance, Stephen R Hooper, Eniko Rak
PURPOSE: Low health literacy adversely affects health outcomes in adults with chronic kidney disease. The current study examined associations between limited/inadequate health literacy and health services utilization among adolescents and young adults (AYA) with chronic or end-stage kidney disease (CKD or ESKD). DESIGN AND METHODS: This was a retrospective cohort study that enrolled patients from both the pediatric- and adult-focused nephrology clinics of a major university hospital...
October 31, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29137506/measuring-the-impact-of-cash-transfers-and-behavioral-nudges-on-maternity-care-in-nairobi-kenya
#13
Jessica Cohen, Claire Rothschild, Ginger Golub, George N Omondi, Margaret E Kruk, Margaret McConnell
Many patients in low-income countries express preferences for high-quality health care but often end up with low-quality providers. We conducted a randomized controlled trial with pregnant women in Nairobi, Kenya, to analyze whether cash transfers, enhanced with behavioral "nudges," can help women deliver in facilities that are consistent with their preferences and are of higher quality. We tested two interventions. The first was a labeled cash transfer (LCT), which explained that the cash was to help women deliver where they wanted...
November 2017: Health Affairs
https://www.readbyqxmd.com/read/29134193/snowball-earth-climate-dynamics-and-cryogenian-geology-geobiology
#14
Paul F Hoffman, Dorian S Abbot, Yosef Ashkenazy, Douglas I Benn, Jochen J Brocks, Phoebe A Cohen, Grant M Cox, Jessica R Creveling, Yannick Donnadieu, Douglas H Erwin, Ian J Fairchild, David Ferreira, Jason C Goodman, Galen P Halverson, Malte F Jansen, Guillaume Le Hir, Gordon D Love, Francis A Macdonald, Adam C Maloof, Camille A Partin, Gilles Ramstein, Brian E J Rose, Catherine V Rose, Peter M Sadler, Eli Tziperman, Aiko Voigt, Stephen G Warren
Geological evidence indicates that grounded ice sheets reached sea level at all latitudes during two long-lived Cryogenian (58 and ≥5 My) glaciations. Combined uranium-lead and rhenium-osmium dating suggests that the older (Sturtian) glacial onset and both terminations were globally synchronous. Geochemical data imply that CO2 was 10(2) PAL (present atmospheric level) at the younger termination, consistent with a global ice cover. Sturtian glaciation followed breakup of a tropical supercontinent, and its onset coincided with the equatorial emplacement of a large igneous province...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29122942/a-special-report-on-the-nhlbi-initiative-to-study-cellular-and-molecular-mechanisms-of-arterial-stiffness-and-its-association-with-hypertension
#15
Young S Oh, Dan E Berkowitz, Richard A Cohen, C Alberto Figueroa, David G Harrison, Jay D Humphrey, Douglas F Larson, Jane A Leopold, Robert P Mecham, Nelson Ruiz-Opazo, Lakshmi Santhanam, Francesca Seta, John Y J Shyy, Zhongjie Sun, Philip S Tsao, Jessica E Wagenseil, Zorina S Galis
No abstract text is available yet for this article.
November 10, 2017: Circulation Research
https://www.readbyqxmd.com/read/29117965/diagnostic-accuracy-of-the-d-dimer-in-children
#16
Jessica Kanis, Cassandra L Hall, Jonathan Pike, Jeffrey A Kline
BACKGROUND: We sought to measure the diagnostic accuracy of D-dimer in children with suspected pulmonary embolism (PE). METHODS: We queried our electronic medical record for quantitative D-dimer values obtained in all children ages 5-17 over 10 years in our 10-hospital system. Patients who had a D-dimer obtained in the evaluation of PE underwent supervised chart review to extract baseline demographics (age, sex, ethnicity), medical history, laboratory data and imaging results...
November 8, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29112050/inference-with-difference-in-differences-with-a-small-number-of-groups-a-review-simulation-study-and-empirical-application-using-share-data
#17
Slawa Rokicki, Jessica Cohen, Günther Fink, Joshua A Salomon, Mary Beth Landrum
BACKGROUND: Difference-in-differences (DID) estimation has become increasingly popular as an approach to evaluate the effect of a group-level policy on individual-level outcomes. Several statistical methodologies have been proposed to correct for the within-group correlation of model errors resulting from the clustering of data. Little is known about how well these corrections perform with the often small number of groups observed in health research using longitudinal data. METHODS: First, we review the most commonly used modeling solutions in DID estimation for panel data, including generalized estimating equations (GEE), permutation tests, clustered standard errors (CSE), wild cluster bootstrapping, and aggregation...
November 3, 2017: Medical Care
https://www.readbyqxmd.com/read/29031721/cdkal1-a-type-2-diabetes-susceptibility-gene-regulates-mitochondrial-function-in-adipose-tissue
#18
Colin J Palmer, Raphael J Bruckner, Joao A Paulo, Lawrence Kazak, Jonathan Z Long, Amir I Mina, Zhaoming Deng, Katherine B LeClair, Jessica A Hall, Shangyu Hong, Peter-James H Zushin, Kyle L Smith, Steven P Gygi, Susan Hagen, David E Cohen, Alexander S Banks
OBJECTIVES: Understanding how loci identified by genome wide association studies (GWAS) contribute to pathogenesis requires new mechanistic insights. Variants within CDKAL1 are strongly linked to an increased risk of developing type 2 diabetes and obesity. Investigations in mouse models have focused on the function of Cdkal1 as a tRNA(Lys) modifier and downstream effects of Cdkal1 loss on pro-insulin translational fidelity in pancreatic β-cells. However, Cdkal1 is broadly expressed in other metabolically relevant tissues, including adipose tissue...
October 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29026520/work-related-musculoskeletal-injuries-sustained-by-australian-osteopaths-qualitative-analysis-of-effects-on-practitioner-health-clinical-practice-and-patient-care
#19
Gopi Anne McLeod, Katerina Annels, Jessica Cohen, Samuel Edwards, Daniel Hodgins, Brett Vaughan
BACKGROUND: There is limited literature that explores the experiences of osteopaths injured while engaging in clinical practice. Evidence from other similar health professions has described the numerous effects of work-related musculoskeletal injuries (WRMI). Work-related musculoskeletal injury refers to trauma to joints, ligaments, muscles and tendons resulting from injury sustained while undertaking work duties. This research aimed to gain a contextualised understanding of the experiences of osteopaths who have sustained a work-related musculoskeletal injury while performing clinical practice...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28981986/the-menstrual-cycle-and-blood-loss-during-laparoscopic-myomectomy
#20
Nisse V Clark, Karen C Wang, Jessica Opoku-Anane, Catherine I Hill-Lydecker, Allison F Vitonis, Jon I Einarsson, Sarah L Cohen
INTRODUCTION: Operative morbidity of laparoscopic myomectomy largely relates to the potential for intraoperative blood loss. We sought to determine if blood loss varies according to the menstrual cycle. MATERIAL AND METHODS: A retrospective review of 268 women who underwent a laparoscopic myomectomy from 2007 to 2012. Patients were categorized into five menstrual groups: follicular phase, luteal phase, oligomenorrheic or amenorrheic on hormonal therapy, postmenopausal or other...
October 5, 2017: Acta Obstetricia et Gynecologica Scandinavica
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