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Jessica Cohen

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https://www.readbyqxmd.com/read/29792742/screening-mammography-findings-from-one-standard-projection-only-in-the-era-of-full-field-digital-mammography-and-digital-breast-tomosynthesis
#1
Ethan O Cohen, Hilda H Tso, Kanchan A Phalak, Ray C Mayo, Jessica W T Leung
OBJECTIVE: The purpose of this article is to compare outcomes of findings seen on one view only from screening full-field digital mammography (FFDM) and FFDM plus digital breast tomosynthesis (DBT). MATERIALS AND METHODS: A retrospective review was performed of 103,070 consecutive screening mammograms obtained from February 2011 through June 2014 at two community-based breast centers. Recalled findings prospectively seen on one view only were analyzed. Pearson chi-square test and Fisher exact test were performed, and 95% CIs were determined...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29771690/heavily-pigmented-epithelioid-melanoma-with-loss-of-protein-kinase-a-regulatory-subunit-%C3%AE-expression
#2
Jarish N Cohen, Jessica A Spies, Fawn Ross, Angela Bohlke, Timothy H McCalmont
Heavily pigmented melanocytic neoplasms are genotypically and phenotypically diverse. Recently, a subset of this histopathologic spectrum was shown to harbor recurrent genetic alterations in the gene-encoding protein kinase A regulatory subunit-α (PRKAR1A). To date, no histopathologic descriptions of melanomas arising from this pathway have been described. We present a case of a darkly pigmented papule arising on the posterior neck of a 28-year-old man. Microscopically, the heavily pigmented compound melanocytic proliferation was centered in the dermis with permeation into the superficial subcutis...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29762252/high-intensity-interval-or-continuous-moderate-exercise-a-24-week-pilot-trial
#3
Sean R Locke, Jessica E Bourne, Mark R Beauchamp, Jonathan P Little, Julianne Barry, Joel Singer, Mary E Jung
PURPOSE: High-intensity interval training (HIIT) may lead to superior cardiometabolic improvements when compared to moderate-intensity continuous training (MICT). However, adherence to HIIT requires examination. The purpose of this pilot study was to examine moderate-to-vigorous physical activity (MVPA) adherence 24 weeks following a brief counselling intervention combined with either HIIT or MICT. METHODS: Individuals at high risk of type 2 diabetes (T2D) were randomized to HIIT (n = 15) or MICT (n = 17) and completed 10 exercise sessions accompanied by a brief 10-minute counselling intervention over a 2-week period...
May 14, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29750396/a-phase-1-2-dose-finding-safety-and-activity-study-of-cabazitaxel-in-pediatric-patients-with-refractory-solid-tumors-including-tumors-of-the-central-nervous-system
#4
Peter E Manley, Tanya Trippett, Amy A Smith, Margaret E Macy, Sarah E S Leary, Jessica Boklan, Kenneth J Cohen, Stewart Goldman, Lindsay B Kilburn, Girish Dhall, Jeanne Devin, Cynthia E Herzog, Sonia Partap, Floris Fauchet, Emmy Badreddine, John P Bernard, Susan N Chi
BACKGROUND: This phase 1/2 study (NCT01751308) evaluated cabazitaxel in pediatric patients. Phase 1 determined the maximum tolerated dose (MTD) in patients with recurrent/refractory solid tumors, including central nervous system (CNS) tumors. Phase 2 evaluated activity in pediatric recurrent high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG). PROCEDURE: In phase 1, a 3 + 3 dose-escalation study design was followed. Cabazitaxel was administered at a starting dose of 20 mg/m2 ...
May 11, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29721192/pd-l1-expression-in-medulloblastoma-an-evaluation-by-subgroup
#5
Allison M Martin, Christopher J Nirschl, Magda J Polanczyk, W Robert Bell, Thomas R Nirschl, Sarah Harris-Bookman, Jillian Phallen, Jessica Hicks, Daniel Martinez, Aleksandra Ogurtsova, Haiying Xu, Lisa M Sullivan, Alan K Meeker, Eric H Raabe, Kenneth J Cohen, Charles G Eberhart, Peter C Burger, Mariarita Santi, Janis M Taube, Drew M Pardoll, Charles G Drake, Michael Lim
Background: This study evaluated the expression of PD-L1 and markers of immune mediated resistance in human medulloblastoma (MB), the most common malignant pediatric brain tumor. Results: Overall levels of PD-L1 in human MB were low; however, some cases demonstrated robust focal expression associated with increased immune infiltrates. The case with highest PD-L1 expression was a sonic hedgehog (SHH) MB. In cell lines, SHH MB, which are low-MYC expressing, demonstrated both constitutive and inducible expression of PD-L1 while those in Group 3/4 that expressed high levels of MYC had only inducible expression...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29709285/prenatal-exposure-to-sand-and-dust-storms-and-children-s-cognitive-function-in-china-a-quasi-experimental-study
#6
Zhihui Li, Lincoln Chen, Mingqiang Li, Jessica Cohen
BACKGROUND: While there is evidence that sand and dust storms can have adverse health effects, the effects of such storms on children's cognitive function has not been explored. We examined whether prenatal exposure to sand and dust storms affects children's cognitive function and, if so, whether harmful effects of sand and dust storms vary by the trimester of exposure. METHODS: This study used nationally representative data from the China Family Panel Studies between 2010 and 2014 and data on sand and dust storms from the national Sand and Dust Weather Almanac...
May 2018: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29701486/can-an-automated-sleep-detection-algorithm-for-waist-worn-accelerometry-replace-sleep-logs
#7
Tiago V Barreira, Jessica G Redmond, Tom D Brutsaert, John M Schuna, Emily F Mire, Peter T Katzmarzyk, Catrine Tudor-Locke
The purpose of this study was to test whether estimates of bedtime, wake time, and sleep period time (SPT) were comparable between an automated algorithm (ALG) applied to waist-worn accelerometry data and a sleep log (LOG), in an adult sample. A total of 104 participants were asked to log evening bedtime and morning wake time and wear an ActiGraph GT3X+ accelerometer at their waist 24 h/days for 7 consecutive days. Mean difference (MD) and mean absolute difference (MAD) were computed. Pearson correlations and dependent sample t-tests were used to compare LOG-based and ALG-based sleep variables...
April 27, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29674185/associations-of-prenatal-and-child-sugar-intake-with-child-cognition
#8
Juliana F W Cohen, Sheryl L Rifas-Shiman, Jessica Young, Emily Oken
INTRODUCTION: Sugar consumption among Americans is above recommended limits, and excess sugar intake may influence cognition. The aim of this study was to examine associations of pregnancy and offspring sugar consumption (sucrose, fructose) with child cognition. Additionally, associations of maternal and child consumption of sugar-sweetened beverages (SSBs), other beverages (diet soda, juice), and fruit with child cognition were examined. METHODS: Among 1,234 mother-child pairs enrolled 1999-2002 in Project Viva, a pre-birth cohort, in 2017 diet was assessed during pregnancy and early childhood, and cognitive outcomes in early and mid-childhood (median ages 3...
April 9, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29665518/early-intervention-for-adolescents-at-risk-for-bipolar-disorder-a-pilot-randomized-trial-of-interpersonal-and-social-rhythm-therapy-ipsrt
#9
Tina R Goldstein, John Merranko, Megan Krantz, Matthew Garcia, Peter Franzen, Jessica Levenson, David Axelson, Boris Birmaher, Ellen Frank
OBJECTIVE: To conduct a pilot randomized trial of Interpersonal and Social Rhythm Therapy plus Data-Informed Referral (IPSRT + DIR) versus DIR-alone for adolescents at-risk for bipolar disorder (BP). METHOD: Eligible participants included youth (12-18) with a BP parent; youth with BP were excluded. Participants (n = 42) were randomized to receive IPSRT + DIR to treat any psychiatric disorders present at baseline, or DIR-alone. A blind evaluator assessed outcomes at baseline, 3- and 6-months...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29629761/small-gd-iii-tags-for-gd-iii-gd-iii-distance-measurements-in-proteins-by-epr-spectroscopy
#10
Georgia Prokopiou, Michael D Lee, Alberto Collauto, Elwy H Abdelkader, Thorsten Bahrenberg, Akiva Feintuch, Marie Ramirez-Cohen, Jessica Clayton, James D Swarbrick, Bim Graham, Gottfried Otting, Daniella Goldfarb
The C7-Gd and C8-Gd tags are compact hydrophilic cyclen-based lanthanide tags for conjugation to cysteine residues in proteins. The tags are enantiomers, which differ in the configuration of the 2-hydroxylpropyl pendant arms coordinating the lanthanide ion. Here, we report the electron paramagnetic resonance (EPR) performance of the C7-Gd ( S configuration) and C8-Gd ( R configuration) tags loaded with Gd(III) on two mutants of the homodimeric ERp29 protein. The W-band EPR spectra were found to differ between the tags in the free state and after conjugation to the protein...
April 9, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29626598/ewsr1-nfatc2-gene-fusion-in-a-soft-tissue-tumor-with-epithelioid-round-cell-morphology-and-abundant-stroma-a-case-report-and-review-of-the-literature
#11
Jarish N Cohen, Amit J Sabnis, Gregor Krings, Soo-Jin Cho, Andrew E Horvai, Jessica L Davis
Mesenchymal round cell tumors are a diverse group of neoplasms defined by primitive, often high-grade cytomorphology. The most common molecular alterations detected in these tumors are gene rearrangements involving EWSR1 to one of many fusion partners. Rare EWSR1-NFATC2 gene rearrangements, corresponding to a t(20;22) gene translocation, have been described in mesenchymal tumors with clear round cell morphology and a predilection for the skeleton. We present a case of a tumor harboring the EWSR1-NFATC2 gene fusion arising in the subcutaneous tissue of a young woman...
April 4, 2018: Human Pathology
https://www.readbyqxmd.com/read/29622127/problem-solving-mr-imaging-for-equivocal-imaging-findings-and-indeterminate-clinical-symptoms-of-the-breast
#12
REVIEW
Ethan Cohen, Jessica W T Leung
Breast MR imaging is commonly used for high-risk screening and for assessing the extent of disease in patients with newly diagnosed breast cancer, but its utility for assessing suspicious symptoms and equivocal imaging findings is less widely accepted. The authors review current literature and guidelines regarding the use of breast MR imaging for these indications. Overall, problem-solving breast MR imaging is best reserved for pathologic nipple discharge and sonographically occult architectural distortion with limited biopsy options...
May 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29618564/postnatal-zika-virus-infection-is-associated-with-persistent-abnormalities-in-brain-structure-function-and-behavior-in-infant-macaques
#13
Maud Mavigner, Jessica Raper, Zsofia Kovacs-Balint, Sanjeev Gumber, Justin T O'Neal, Siddhartha K Bhaumik, Xiaodong Zhang, Jakob Habib, Cameron Mattingly, Circe E McDonald, Victoria Avanzato, Mark W Burke, Diogo M Magnani, Varian K Bailey, David I Watkins, Thomas H Vanderford, Damien Fair, Eric Earl, Eric Feczko, Martin Styner, Sherrie M Jean, Joyce K Cohen, Guido Silvestri, R Paul Johnson, David H O'Connor, Jens Wrammert, Mehul S Suthar, Mar M Sanchez, Maria C Alvarado, Ann Chahroudi
The Zika virus (ZIKV) epidemic is associated with fetal brain lesions and other serious birth defects classified as congenital ZIKV syndrome. Postnatal ZIKV infection in infants and children has been reported; however, data on brain anatomy, function, and behavioral outcomes following infection are absent. We show that postnatal ZIKV infection of infant rhesus macaques (RMs) results in persistent structural and functional alterations of the central nervous system compared to age-matched controls. We demonstrate ZIKV lymphoid tropism and neurotropism in infant RMs and histopathologic abnormalities in the peripheral and central nervous systems including inflammatory infiltrates, astrogliosis, and Wallerian degeneration...
April 4, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29616137/video-monitoring-a-simulation-based-quality-improvement-program-in-bihar-india
#14
Jessica Dyer, Hilary Spindler, Amelia Christmas, Malay Bharat Shah, Melissa Morgan, Susanna R Cohen, Jason Sterne, Tanmay Mahapatra, Dilys Walker
Background: Simulation-based training has become an accepted clinical training andragogy in high-resource settings with its use increasing in low-resource settings. Video recordings of simulated scenarios are commonly used by facilitators. Beyond using the videos during debrief sessions, researchers can also analyze the simulation videos to quantify technical and nontechnical skills during simulated scenarios over time. Little is known about the feasibility and use of large-scale systems to video record and analyze simulation and debriefing data for monitoring and evaluation in low-resource settings...
April 2018: Clinical Simulation in Nursing
https://www.readbyqxmd.com/read/29611711/an-irt-analysis-of-the-reading-the-mind-in-the-eyes-test
#15
Jessica E Black
The Reading the Mind in the Eyes Test (RMET; Baron-Cohen, Wheelwright, Hill, Raste, & Plumb, 2001 ), originally designed for use in clinical populations, has been used with increasing frequency as a measure of advanced social cognition in nonclinical samples (e.g., Domes, Heinriches, Michel, Berger, & Herpertz, 2007 ; Kidd & Castano, 2013 ; Mar, Oatley, Hirsh, de la Paz, & Peterson, 2006 ). The purpose of this research was to use item response theory to assess the ability of the RMET to detect differences at the high levels of theory of mind to be expected in neurotypical adults...
April 3, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29601453/safety-effectiveness-and-exposure-response-of-micafungin-in-infants-application-of-an-established-pharmacokinetics-model-to-electronic-health-records
#16
Nazario D Rivera-Chaparro, Jessica Ericson, Huali Wu, P Brian Smith, Reese H Clark, Daniel K Benjamin, Michael Cohen-Wolkowiez, Rachel G Greenberg
Micafungin is used off-label in the United States to treat invasive candidiasis in neonates. We used an established pharmacokinetic model to determine micafungin exposures for 46 courses in 39 hospitalized infants. In this small cohort of infants, micafungin exposure was not associated with laboratory markers of liver toxicity, death, or failure of microbiological clearance.
March 29, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29599112/clinical-monitoring-of-well-appearing-infants-born-to-mothers-with-chorioamnionitis
#17
Neha S Joshi, Arun Gupta, Jessica M Allan, Ronald S Cohen, Janelle L Aby, Brittany Weldon, Juliann L Kim, William E Benitz, Adam Frymoyer
BACKGROUND: The risk of early-onset sepsis is low in well-appearing late-preterm and term infants even in the setting of chorioamnionitis. The empirical antibiotic strategies for chorioamnionitis-exposed infants that are recommended by national guidelines result in antibiotic exposure for numerous well-appearing, uninfected infants. We aimed to reduce unnecessary antibiotic use in chorioamnionitis-exposed infants through the implementation of a treatment approach that focused on clinical presentation to determine the need for antibiotics...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29558436/motor-planning-error-toward-measuring-cognitive-frailty-in-older-adults-using-wearables
#18
He Zhou, Hyoki Lee, Jessica Lee, Michael Schwenk, Bijan Najafi
Practical tools which can be quickly administered are needed for measuring subtle changes in cognitive-motor performance over time. Frailty together with cognitive impairment, or 'cognitive frailty', are shown to be strong and independent predictors of cognitive decline over time. We have developed an interactive instrumented trail-making task (iTMT) platform, which allows quantification of motor planning error (MPE) through a series of ankle reaching tasks. In this study, we examined the accuracy of MPE in identifying cognitive frailty in older adults...
March 20, 2018: Sensors
https://www.readbyqxmd.com/read/29553778/the-burden-of-co-occurring-alcohol-use-disorder-and-ptsd-in-u-s-military-veterans-comorbidities-functioning-and-suicidality
#19
Sonya B Norman, Moira Haller, Jessica L Hamblen, Steven M Southwick, Robert H Pietrzak
Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are among the most prevalent disorders in U.S. military veterans and often co-occur. To date, most studies have focused on treatment-seeking samples, although many veterans with AUD/PTSD do not seek treatment. We evaluated the prevalence of psychiatric comorbidities, functioning, and quality of life in a nationally representative sample of U.S. veterans (using data from the National Health and Resilience in Veterans Study) with AUD alone, PTSD alone, and comorbid AUD/PTSD to understand the incremental burden of having both disorders relative to either one...
March 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29553629/precommitment-cash-transfers-and-timely-arrival-for-birth-evidence-from-a-randomized-controlled-trial-in-nairobi-kenya
#20
Jessica Cohen, Katherine Lofgren, Margaret McConnell
No abstract text is available yet for this article.
May 2017: American Economic Review
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