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Jessica Cohen

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https://www.readbyqxmd.com/read/28089765/intracerebroventricular-delivery-as-a-safe-long-term-route-of-administration
#1
REVIEW
Jessica L Cohen-Pfeffer, Sridharan Gururangan, Thomas Lester, Daniel A Lim, Adam J Shaywitz, Manfred Westphal, Irene Slavc
Intrathecal delivery methods have been used for many decades to treat a broad range of central nervous system disorders. A literature review demonstrated that intracerebroventricular route is an established and well-tolerated method for prolonged central nervous system drug delivery in pediatric and adult populations. Intracerebroventricular devices were present in patients from one to 7156 days. The number of punctures per device ranged from 2 to 280. Noninfectious complication rates per patient (range, 1...
November 10, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/28081302/education-and-support-needs-in-patients-with-head-and-neck-cancer-a-multi-institutional-survey
#2
Joe Jabbour, Chris Milross, Puma Sundaresan, Ardalan Ebrahimi, Heather L Shepherd, Haryana M Dhillon, Gary Morgan, Bruce Ashford, Muzib Abdul-Razak, Eva Wong, Michael Veness, Carsten E Palme, Cate Froggatt, Ruben Cohen, Rafael Ekmejian, Jessica Tay, David Roshan, Jonathan R Clark
BACKGROUND: Head and neck cancer (HNC) encompasses a diverse group of tumors, and thus providing appropriate and tailored information to patients before, during, and after treatment is a challenge. The objective of the current study was to characterize the experience and unmet needs of patients with HNC with regard to information and support provision. METHODS: A 28-question, cross-sectional survey was completed by patients treated for HNC at 1 of 4 institutions in New South Wales, Australia (Chris O'Brien Lifehouse and Liverpool, Westmead, and Wollongong hospitals)...
January 12, 2017: Cancer
https://www.readbyqxmd.com/read/28081041/a-systematic-literature-review-approach-to-estimate-the-therapeutic-index-of-selected-immunosuppressant-drugs-after-renal-transplantation
#3
Jessica E Ericson, Kanecia O Zimmerman, Daniel Gonzalez, Chiara Melloni, Jeffrey T Guptill, Kevin D Hill, Huali Wu, Michael Cohen-Wolkowiez
BACKGROUND: Drugs that exhibit close margins between therapeutic and toxic blood concentrations are considered to have a narrow therapeutic index (NTI). The Food and Drug Administration has proposed that NTI drugs should have more stringent bioequivalence standards for approval of generic formulations. However, many immunosuppressant drugs do not have a well-defined therapeutic index (TI). METHODS: We sought to determine whether safety, efficacy, and pharmacokinetic data obtained from the medical literature through a comprehensive literature search could be used to estimate the TI of cyclosporine, tacrolimus, and sirolimus...
February 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28061033/breastfeeding-infants-with-ankyloglossia-insight-into-mothers-experiences
#4
Kevin Wong, Punam Patel, Michael B Cohen, Jessica R Levi
INTRODUCTION: Breastfeeding difficulty from ankyloglossia can affect both the mother and baby in a breastfeeding dyad. With renewed emphasis in today's culture on breast milk, mothers may feel increasing pressure to breastfeed, and the inability for some to do so may cause significant distress. Recently, online parenting forums have seen exponential growth; these forums allow mothers to connect with peers undergoing similar life transitions. The purpose of this study was to review online discussions regarding ankyloglossia to understand mothers' experiences with breastfeeding...
January 6, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28043901/mother-child-language-style-matching-predicts-children-s-and-mothers-emotion-reactivity
#5
Hannah F Rasmussen, Jessica L Borelli, Patricia A Smiley, Chloe Cohen, Ryan Cheuk Ming Cheung, Schuyler Fox, Matthew Marvin, Betsy Blackard
Co-regulation of behavior occurring within parent-child attachment relationships is thought to be the primary means through which children develop the capacity to regulate emotion, an ability that is protective across development. Existing research on parent-child co-regulation focuses predominantly on parent-infant dyads, and operationalizes co-regulation as the matching of facial expressions; however, matching can occur on other behaviors, including vocal tone, body movement, and language. Studies with young children find that greater matching is associated with children's lower emotion reactivity, but with unknown impacts on parents...
December 30, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27997236/impact-of-a-text-messaging-program-on-adolescent-reproductive-health-a-cluster-randomized-trial-in-ghana
#6
Slawa Rokicki, Jessica Cohen, Joshua A Salomon, Günther Fink
OBJECTIVES: To evaluate whether text-messaging programs can improve reproductive health among adolescent girls in low- and middle-income countries. METHODS: We conducted a cluster-randomized controlled trial among 756 female students aged 14 to 24 years in Accra, Ghana, in 2014. We randomized 38 schools to unidirectional intervention (n = 12), interactive intervention (n = 12), and control (n = 14). The unidirectional intervention sent participants text messages with reproductive health information...
February 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27996898/the-legality-of-biometric-screening-of-professional-athletes
#7
Jessica L Roberts, I Glenn Cohen, Christopher R Deubert, Holly Fernandez Lynch
No abstract text is available yet for this article.
January 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/27974697/surrogate-in-vitro-activation-of-innate-immunity-synergizes-with-interleukin-7-to-unleash-rapid-antigen-driven-outgrowth-of-cd4-and-cd8-human-peripheral-blood-t-cells-naturally-recognizing-muc1-her2-neu-and-other-tumor-associated-antigens
#8
Latha B Pathangey, Dustin B McCurry, Sandra J Gendler, Ana L Dominguez, Jessica E Gorman, Girish Pathangey, Laurie A Mihalik, Yushe Dang, Mary L Disis, Peter A Cohen
Effective adoptive immunotherapy has proved elusive for many types of human cancer, often due to difficulties achieving robust expansion of natural tumor-specific T-cells from peripheral blood. We hypothesized that antigen-driven T-cell expansion might best be triggered in vitro by acute activation of innate immunity to mimic a life-threatening infection. Unfractionated peripheral blood mononuclear cells (PBMC) were subjected to a two-step culture, first synchronizing their exposure to exogenous antigens with aggressive surrogate activation of innate immunity, followed by γ-chain cytokine-modulated T-cell hyperexpansion...
December 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27958883/glutaredoxin-1-deficiency-causes-fatty-liver-and-dyslipidemia-by-inhibiting-sirtuin-1
#9
Di Shao, Jingyan Han, Xiuyun Hou, Jessica L Fry, Jessica B Behring, Francesca Seta, Michelle Long, Hemant Roy, Richard A Cohen, Reiko Matsui, Markus Michael Bachschmid
<b>Aims:</b> Non-alcoholic fatty liver (NAFL) is a common liver disease associated with metabolic syndrome, obesity and diabetes that is rising in prevalence worldwide. Various molecular perturbations of key regulators and enzymes in hepatic lipid metabolism cause NAFL. However, redox regulation through glutathione (GSH) adducts in NAFL remains largely elusive. Glutaredoxin-1 (Glrx) is a small thioltransferase that removes protein GSH adducts without having direct antioxidant properties. The liver contains abundant Glrx but its metabolic function is unknown...
December 13, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27903719/the-segregation-and-integration-of-distinct-brain-networks-and-their-relationship-to-cognition
#10
Jessica R Cohen, Mark D'Esposito
: A critical feature of the human brain that gives rise to complex cognition is its ability to reconfigure its network structure dynamically and adaptively in response to the environment. Existing research probing task-related reconfiguration of brain network structure has concluded that, although there are many similarities in network structure during an intrinsic, resting state and during the performance of a variety of cognitive tasks, there are meaningful differences as well. In this study, we related intrinsic, resting state network organization to reconfigured network organization during the performance of two tasks: a sequence tapping task, which is thought to probe motor execution and likely engages a single brain network, and an n-back task, which is thought to probe working memory and likely requires coordination across multiple networks...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27886285/high-mof-loading-in-mixed-matrix-membranes-utilizing-styrene-butadiene-copolymers
#11
Jessica C Moreton, Michael S Denny, Seth M Cohen
A series of styrene/butadiene polymers were combined with up to 90 wt% UiO-66 to form mixed-matrix membranes with varying physical properties. Notably, polystyrene-block-polybutadiene (SBS) membranes retained much of the processability and flexibility of the native polymer component and the porosity, chemical tunability, and adsorption of the native MOF.
December 13, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27881975/membrane-complexes-of-syntrophomonas-wolfei-involved-in-syntrophic-butyrate-degradation-and-hydrogen-formation
#12
Bryan R Crable, Jessica R Sieber, Xinwei Mao, Lisa Alvarez-Cohen, Robert Gunsalus, Rachel R Ogorzalek Loo, Hong Nguyen, Michael J McInerney
Syntrophic butyrate metabolism involves the thermodynamically unfavorable production of hydrogen and/or formate from the high potential electron donor, butyryl-CoA. Such redox reactions can occur only with energy input by a process called reverse electron transfer. Previous studies have demonstrated that hydrogen production from butyrate requires the presence of a proton gradient, but the biochemical machinery involved has not been clearly elucidated. In this study, the gene and enzyme systems involved in reverse electron transfer by Syntrophomonas wolfei were investigated using proteomic and gene expression approaches...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27829189/dti-microstructural-abnormalities-in-adolescent-siblings-of-patients-with-childhood-onset-schizophrenia
#13
Dana Waltzman, Barbara Jean Knowlton, Jessica Rachel Cohen, Susan Yost Bookheimer, Robert Martin Bilder, Robert Franklin Asarnow
No abstract text is available yet for this article.
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27807554/mycobacterium-avium-intracellulare-complex-mac-producing-a-periportal-pseudotumor-in-a-patient-with-hiv-and-a-normal-cd4-count
#14
Jessica Johnson, Meghan Driscoll, Michael Cohen, Douglas G Adler
Mycobacterium avium-intracellulare complex (MAC) is an opportunistic infection typically associated with profound immunosuppression, such as AIDS. The presentation of disseminated MAC can be subtle and mimic systemic symptoms associated with lymphoma; abdominal pseudotumor is an exceptionally rare presentation. In the era of highly active anti-retroviral therapy (HAART), opportunistic infections are increasingly rare, and secondary prophylaxis for MAC may be discontinued after adequate therapy and immune reconstitution...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27797661/a-case-series-on-the-effects-of-kripalu-yoga-for-generalized-anxiety-disorder
#15
Jessica R Morgan, Marlysa Sullivan, Akihiko Masuda, Erin Tully, Lindsey L Cohen, Page L Anderson
Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder associated with substantial impairment and poor treatment response. Yoga influences processes that are linked to the maintenance of GAD including mindfulness, anxiety, and heart rate variability, but has yet to be evaluated among people with the disorder. The present study is a first step toward documenting the efficacy of yoga for reducing worry among people with GAD using a single-subject AB design case series and daily ratings of worry...
January 2016: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/27794549/clinicians-use-of-prescription-drug-monitoring-programs-in-clinical-practice-and-decision-making
#16
Gillian J Leichtling, Jessica M Irvine, Christi Hildebran, Deborah J Cohen, Sara E Hallvik, Richard A Deyo
OBJECTIVES:  Little is known about clinicians' use of prescription drug monitoring program (PDMP) profiles in decision-making. The objective of this qualitative study was to understand how clinicians use, interpret, and integrate PDMP profiles with other information in making clinical decisions. DESIGN : Qualitative interviews of clinician PDMP users. SETTING:  Oregon registrants in the state's PDMP. SUBJECTS:  Thirty-three clinicians practicing in primary care, emergency medicine, pain management, psychiatry, dentistry, and surgery...
October 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27793431/parent-mediated-social-communication-therapy-for-young-children-with-autism-pact-long-term-follow-up-of-a-randomised-controlled-trial
#17
Andrew Pickles, Ann Le Couteur, Kathy Leadbitter, Erica Salomone, Rachel Cole-Fletcher, Hannah Tobin, Isobel Gammer, Jessica Lowry, George Vamvakas, Sarah Byford, Catherine Aldred, Vicky Slonims, Helen McConachie, Patricia Howlin, Jeremy R Parr, Tony Charman, Jonathan Green
BACKGROUND: It is not known whether early intervention can improve long-term autism symptom outcomes. We aimed to follow-up the Preschool Autism Communication Trial (PACT), to investigate whether the PACT intervention had a long-term effect on autism symptoms and continued effects on parent and child social interaction. METHODS: PACT was a randomised controlled trial of a parent-mediated social communication intervention for children aged 2-4 years with core autism...
November 19, 2016: Lancet
https://www.readbyqxmd.com/read/27780873/effects-of-eight-week-web-based-mindfulness-training-on-pain-intensity-pain-acceptance-and-life-satisfaction-in-individuals-with-chronic-pain
#18
Jessica Henriksson, Emma Wasara, Michael Rönnlund
This study examined the effects of an eight-week-web-based mindfulness program designed for individuals with chronic pain. A sample of 107 participants with chronic pain (M = 51.0 years, SD = 9.3) were randomly assigned to a treatment group and a control group. The mindfulness program involved 20 minutes of training per day, six days a week, for eight weeks. During this period, the control group was invited to an online discussion forum involving pain-related topics. A total of 77 participants completed the postintervention assessment (n = 36 in the treatment group, n = 41 in the control group)...
December 2016: Psychological Reports
https://www.readbyqxmd.com/read/27735925/early-manifestations-of-type-1-gaucher-disease-in-presymptomatic-children-diagnosed-after-parental-carrier-screening
#19
Amy C Yang, Louise Bier, Jessica R Overbey, Jessica Cohen-Pfeffer, Khyati Desai, Robert J Desnick, Manisha Balwani
PURPOSE: The overall published experience with pediatric type 1 Gaucher disease (GD1) has been based on ascertainment through clinical presentation of the disease. We describe the longitudinal follow-up in a presymptomatic pediatric cohort. METHODS: The cohort includes children diagnosed with GD1, either prenatally or postnatally by molecular genetic testing, and followed for clinical care at our center from 1998 to 2016. All patients' parents were GBA mutation carriers identified through carrier screening programs...
October 13, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27712028/prediction-of-suicidal-behavior-in-high-risk-psychiatric-patients-using-an-assessment-of-acute-suicidal-state-the-suicide-crisis-inventory
#20
Igor Galynker, Zimri S Yaseen, Abigail Cohen, Ori Benhamou, Mariah Hawes, Jessica Briggs
BACKGROUND: We have developed the Suicide Crisis Inventory (SCI) to evaluate the intensity of the Suicidal Crisis Syndrome, an acute state hypothesized to precede suicide attempt. The psychometric properties of the SCI, including predictive validity for suicidal behavior (SB), were assessed. METHODS: Adult psychiatric patients (n = 201) hospitalized for high suicide risk were assessed. Logistic regression models assessed the SCI's predictive validity for SB in the 4-8 weeks following hospital discharge and its incremental predictive validity over traditional risk factors (n = 137, 64% f/u rate)...
October 6, 2016: Depression and Anxiety
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