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COMMENT
Kenneth Lam, Irena Cenzer, Cari R Levy, Dan D Matlock, Alexander K Smith, Kenneth E Covinsky
IMPORTANCE: Many older persons move into long-term care facilities (LTCFs) due to disability and insufficient home caregiving options. However, the extent of disability and caregiving provided around the time of entry is unknown. OBJECTIVE: To quantitatively describe disability and caregiving before and after LTCF entry, comparing nursing home (NH), assisted living (AL), and independent living (IL) entrants. DESIGN, SETTING, AND PARTICIPANTS: A longitudinal cohort study using prospectively collected annual data from the National Health and Aging Trends Study from 2011 to 2020 including participants in the continental US...
December 1, 2023: JAMA Internal Medicine
#22
Yash Pershad, Taralynn Mack, Hannah Poisner, Yasminka A Jakubek, Adrienne M Stilp, Braxton D Mitchell, Joshua P Lewis, Eric Boerwinkle, Ruth J Loos, Nathalie Chami, Zhe Wang, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M Psaty, Joshua C Bis, Ali Shojaie, Edwin K Silverman, Michael H Cho, Jeong Yun, Dawn DeMeo, Daniel Levy, Andrew Johnson, Rasika Mathias, Margaret Taub, Donna Arnett, Kari North, Laura M Raffield, April Carson, Margaret F Doyle, Stephen S Rich, Jerome I Rotter, Xiuqing Guo, Nancy Cox, Dan M Roden, Nora Franceschini, Pinkal Desai, Alex Reiner, Paul L Auer, Paul Scheet, Siddhartha Jaiswal, Joshua S Weinstock, Alexander G Bick
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural rearrangements called mosaic chromosomal alterations (mCAs). The factors that influence the variations in mCA fitness and ultimately result in different clonal expansion rates are not well-understood. We used the Passenger-Approximated Clonal Expansion Rate (PACER) method to estimate clonal expansion rate for 6,381 individuals in the NHLBI TOPMed cohort with gain, loss, and copy-neutral loss of heterozygosity mCAs...
October 21, 2023: medRxiv
#23
Danny Morick, Vanessa M Bachmann, Eli Shemesh, Ana Maria Botero-Anug, Ziv Zemach-Shamir, Zahi Aizenberg, Nadav Davidovich, Daphne W Goldberg, Gaston Kan, Ron Ofri, Dan Tchernov, Yaniv Levy
Spirorchiid blood flukes are widespread in sea turtles, causing disease and mortality in their populations, with high prevalence in several ocean basins. Besides being leading parasitic causes of sea turtle strandings in several parts of the world, these infectious agents can cause endocarditis, vasculitis, thrombosis, miliary egg granulomas, and aneurysms, which ultimately may compromise the survival of green sea turtles. More severe cases may also result in multifocal granulomatous meningitis or pneumonia, both of which can be fatal...
2023: Frontiers in Veterinary Science
#24
JOURNAL ARTICLE
Khen Cohen, Omer Hershko, Homer Levy, David Mendlovic, Dan Raviv
This work demonstrates a novel, state-of-the-art method to reconstruct colored images via the dynamic vision sensor (DVS). The DVS is an image sensor that indicates only a binary change in brightness, with no information about the captured wavelength (color) or intensity level. However, the reconstruction of the scene's color could be essential for many tasks in computer vision and DVS. We present a novel method for reconstructing a full spatial resolution, colored image utilizing the DVS and an active colored light source...
October 9, 2023: Sensors
#25
JOURNAL ARTICLE
Xue Liu, Xianbang Sun, Yuankai Zhang, Wenqing Jiang, Meng Lai, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Wei Zhao, Achilleas Pitsillides, Jeffrey Haessler, Yinan Zheng, Thomas W Blackwell, Jie Yao, Xiuqing Guo, Yong Qian, Bharat Thyagarajan, Nathan Pankratz, Stephen S Rich, Kent D Taylor, Patricia A Peyser, Susan R Heckbert, Sudha Seshadri, Eric Boerwinkle, Megan L Grove, Nicholas B Larson, Jennifer A Smith, Ramachandran S Vasan, Annette L Fitzpatrick, Myriam Fornage, Jun Ding, April P Carson, Goncalo Abecasis, Josée Dupuis, Alexander Reiner, Charles Kooperberg, Lifang Hou, Bruce M Psaty, James G Wilson, Daniel Levy, Jerome I Rotter, Joshua C Bis, Claudia L Satizabal, Dan E Arking, Chunyu Liu
Background The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive. Methods and Results We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia)...
October 7, 2023: Journal of the American Heart Association
#26
JOURNAL ARTICLE
Yun Soo Hong, Stephanie L Battle, Wen Shi, Daniela Puiu, Vamsee Pillalamarri, Jiaqi Xie, Nathan Pankratz, Nicole J Lake, Monkol Lek, Jerome I Rotter, Stephen S Rich, Charles Kooperberg, Alex P Reiner, Paul L Auer, Nancy Heard-Costa, Chunyu Liu, Meng Lai, Joanne M Murabito, Daniel Levy, Megan L Grove, Alvaro Alonso, Richard Gibbs, Shannon Dugan-Perez, Lukasz P Gondek, Eliseo Guallar, Dan E Arking
Mitochondria carry their own circular genome and disruption of the mitochondrial genome is associated with various aging-related diseases. Unlike the nuclear genome, mitochondrial DNA (mtDNA) can be present at 1000 s to 10,000 s copies in somatic cells and variants may exist in a state of heteroplasmy, where only a fraction of the DNA molecules harbors a particular variant. We quantify mtDNA heteroplasmy in 194,871 participants in the UK Biobank and find that heteroplasmy is associated with a 1...
September 30, 2023: Nature Communications
#27
JOURNAL ARTICLE
Amey Nimkar, Khorsed Alam, Gil Bergman, Mikhael D Levi, Dan Thomas Major, Netanel Shpigel, Doron Aurbach
The introduction of the water-in-salt (WIS) electrolytes concept to prevent water splitting and widen the electrochemical stability window, has spurred extensive research efforts toward development of improved aqueous batteries. The successful implementation of these electrolyte solutions in many electrochemical systems shifts the focus from diluted to WIS electrolyte solutions. Considering the high costs and the tendency of these nearly saturated solutions to crystallize, this trend can be carefully re-evaluated...
September 25, 2023: Angewandte Chemie
#28
Caroline M Nievergelt, Adam X Maihofer, Elizabeth G Atkinson, Chia-Yen Chen, Karmel W Choi, Jonathan Ri Coleman, Nikolaos P Daskalakis, Laramie E Duncan, Renato Polimanti, Cindy Aaronson, Ananda B Amstadter, Soren B Andersen, Ole A Andreassen, Paul A Arbisi, Allison E Ashley-Koch, S Bryn Austin, Esmina Avdibegoviç, Dragan Babic, Silviu-Alin Bacanu, Dewleen G Baker, Anthony Batzler, Jean C Beckham, Sintia Belangero, Corina Benjet, Carisa Bergner, Linda M Bierer, Joanna M Biernacka, Laura J Bierut, Jonathan I Bisson, Marco P Boks, Elizabeth A Bolger, Amber Brandolino, Gerome Breen, Rodrigo Affonseca Bressan, Richard A Bryant, Angela C Bustamante, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Anders D Børglum, Sigrid Børte, Leah Cahn, Joseph R Calabrese, Jose Miguel Caldas-de-Almeida, Chris Chatzinakos, Sheraz Cheema, Sean A P Clouston, LucÍa Colodro-Conde, Brandon J Coombes, Carlos S Cruz-Fuentes, Anders M Dale, Shareefa Dalvie, Lea K Davis, Jürgen Deckert, Douglas L Delahanty, Michelle F Dennis, Terri deRoon-Cassini, Frank Desarnaud, Christopher P DiPietro, Seth G Disner, Anna R Docherty, Katharina Domschke, Grete Dyb, Alma Dzubur Kulenovic, Howard J Edenberg, Alexandra Evans, Chiara Fabbri, Negar Fani, Lindsay A Farrer, Adriana Feder, Norah C Feeny, Janine D Flory, David Forbes, Carol E Franz, Sandro Galea, Melanie E Garrett, Bizu Gelaye, Joel Gelernter, Elbert Geuze, Charles F Gillespie, Aferdita Goci, Slavina B Goleva, Scott D Gordon, Lana Ruvolo Grasser, Camila Guindalini, Magali Haas, Saskia Hagenaars, Michael A Hauser, Andrew C Heath, Sian Mj Hemmings, Victor Hesselbrock, Ian B Hickie, Kelleigh Hogan, David Michael Hougaard, Hailiang Huang, Laura M Huckins, Kristian Hveem, Miro Jakovljevic, Arash Javanbakht, Gregory D Jenkins, Jessica Johnson, Ian Jones, Tanja Jovanovic, Karen-Inge Karstoft, Milissa L Kaufman, James L Kennedy, Ronald C Kessler, Alaptagin Khan, Nathan A Kimbrel, Anthony P King, Nastassja Koen, Roman Kotov, Henry R Kranzler, Kristi Krebs, William S Kremen, Pei-Fen Kuan, Bruce R Lawford, Lauren A M Lebois, Kelli Lehto, Daniel F Levey, Catrin Lewis, Israel Liberzon, Sarah D Linnstaedt, Mark W Logue, Adriana Lori, Yi Lu, Benjamin J Luft, Michelle K Lupton, Jurjen J Luykx, Iouri Makotkine, Jessica L Maples-Keller, Shelby Marchese, Charles Marmar, Nicholas G Martin, Gabriela A MartÍnez-Levy, Kerrie McAloney, Alexander McFarlane, Katie A McLaughlin, Samuel A McLean, Sarah E Medland, Divya Mehta, Jacquelyn Meyers, Vasiliki Michopoulos, Elizabeth A Mikita, Lili Milani, William Milberg, Mark W Miller, Rajendra A Morey, Charles Phillip Morris, Ole Mors, Preben Bo Mortensen, Mary S Mufford, Elliot C Nelson, Merete Nordentoft, Sonya B Norman, Nicole R Nugent, Meaghan O'Donnell, Holly K Orcutt, Pedro M Pan, Matthew S Panizzon, Gita A Pathak, Edward S Peters, Alan L Peterson, Matthew Peverill, Robert H Pietrzak, Melissa A Polusny, Bernice Porjesz, Abigail Powers, Xue-Jun Qin, Andrew Ratanatharathorn, Victoria B Risbrough, Andrea L Roberts, Barbara O Rothbaum, Alex O Rothbaum, Peter Roy-Byrne, Kenneth J Ruggiero, Ariane Rung, Heiko Runz, Bart P F Rutten, Stacey Saenz de Viteri, Giovanni Abrahão Salum, Laura Sampson, Sixto E Sanchez, Marcos Santoro, Carina Seah, Soraya Seedat, Julia S Seng, Andrey Shabalin, Christina M Sheerin, Derrick Silove, Alicia K Smith, Jordan W Smoller, Scott R Sponheim, Dan J Stein, Synne Stensland, Jennifer S Stevens, Jennifer A Sumner, Martin H Teicher, Wesley K Thompson, Arun K Tiwari, Edward Trapido, Monica Uddin, Robert J Ursano, Unnur Valdimarsdóttir, Leigh Luella van den Heuvel, Miranda Van Hooff, Sanne Jh van Rooij, Eric Vermetten, Christiaan H Vinkers, Joanne Voisey, Zhewu Wang, Yunpeng Wang, Monika Waszczuk, Heike Weber, Frank R Wendt, Thomas Werge, Michelle A Williams, Douglas E Williamson, Bendik S Winsvold, Sherry Winternitz, Erika J Wolf, Christiane Wolf, Yan Xia, Ying Xiong, Rachel Yehuda, Ross McD Young, Keith A Young, Clement C Zai, Gwyneth C Zai, Mark Zervas, Hongyu Zhao, Lori A Zoellner, John-Anker Zwart, Murray B Stein, Kerry J Ressler, Karestan C Koenen
Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 novel)...
September 2, 2023: medRxiv
#29
JOURNAL ARTICLE
Margarita Kublanovsky, Gizem T Ulu, Sara Weirich, Nurit Levy, Michal Feldman, Albert Jeltsch, Dan Levy
The protein lysine methyltransferase SETD6 has been shown to influence different cellular activities and to be critically involved in the regulation of diverse developmental and pathological processes. However, the upstream signals which regulate the mRNA expression of SETD6 are not known. Bioinformatic analysis revealed that the SETD6 promoter has a binding site for the transcription factor E2F1. Using various experimental approaches, we show that E2F1 binds to the SETD6 promoter and regulates SETD6 mRNA expression...
September 8, 2023: Journal of Biological Chemistry
#30
JOURNAL ARTICLE
Olav Søvik, Arnstein Tveiten, Halvor Øygarden, Pål Johan Stokkeland, Hanne Brit Hetland, Magnus Sundgot Schneider, Knut Olav Sandve, Marianne Altmann, Dan Levi Hykkerud, Johanna Ospel, Mayank Goyal, Hege Langli Ersdal, Martin Wilhelm Kurz, Per Kristian Hyldmo
BACKGROUND: Virtual reality simulation training may improve the technical skills of interventional radiologists when establishing endovascular thrombectomy at limited-volume stroke centers. The aim of this study was to investigate whether the technical thrombectomy performance of interventional radiologists improved after a defined virtual reality simulator training period. As part of the quality surveillance of clinical practice, we also assessed patient outcomes and thrombectomy quality indicators at the participating centers...
September 6, 2023: Interventional Neuroradiology
#31
JOURNAL ARTICLE
Ofer Margalit, Einat Shacham-Shmueli, Gal Strauss, Yu-Xiao Yang, Yaacov R Lawerence, Alon Ben Nun, Idan Levy, Kim A Reiss, Talia Golan, Naama Halpern, Dan Aderka, Bruce Giantonio, Ronac Mamtani, Ben Boursi
Current guidelines recommend that clinically staged T1N0 esophageal cancers are to be referred to surgery or endoscopic resection. Using the National Cancer Database we identified 733 individuals with clinically staged T1N0 esophageal carcinoma, who underwent upfront surgery and did not receive any prior treatment. We assessed upstaging, which was defined as ≥ T2 disease or positive lymph nodes. Poorly-differentiated adenocarcinomas were associated with upstaging, whereas squamous cell carcinomas were not...
September 4, 2023: Cancer Investigation
#32
JOURNAL ARTICLE
Nagy A Mekhail, Robert M Levy, Timothy R Deer, Leonardo Kapural, Sean Li, Kasra Amirdelfan, Jason E Pope, Corey W Hunter, Steven M Rosen, Shrif J Costandi, Steven M Falowski, Abram H Burgher, Christopher A Gilmore, Farooq A Qureshi, Peter S Staats, James Scowcroft, Tory McJunkin, Jonathan Carlson, Christopher K Kim, Michael I Yang, Thomas Stauss, Erika A Petersen, Jonathan M Hagedorn, Richard Rauck, Jan W Kallewaard, Ganesan Baranidharan, Rod S Taylor, Lawrence Poree, Dan Brounstein, Rui V Duarte, Gerrit E Gmel, Robert Gorman, Ian Gould, Erin Hanson, Dean M Karantonis, Abeer Khurram, Angela Leitner, Dave Mugan, Milan Obradovic, Zhonghua Ouyang, John Parker, Peter Single, Nicole Soliday
INTRODUCTION: The evidence for spinal cord stimulation (SCS) has been criticized for the absence of blinded, parallel randomized controlled trials (RCTs) and limited evaluations of the long-term effects of SCS in RCTs. The aim of this study was to determine whether evoked compound action potential (ECAP)-controlled, closed-loop SCS (CL-SCS) is associated with better outcomes when compared with fixed-output, open-loop SCS (OL-SCS) 36 months following implant. METHODS: The EVOKE study was a multicenter, participant-blinded, investigator-blinded, and outcome assessor-blinded, randomized, controlled, parallel-arm clinical trial that compared ECAP-controlled CL-SCS with fixed-output OL-SCS...
August 27, 2023: Regional Anesthesia and Pain Medicine
#33
JOURNAL ARTICLE
Levi-Dan Azoulay, Marine Bravetti, Fleur Cohen Aubart, Jean-François Emile, Frédéric Charlotte, Zahir Amoura, Philippe Cluzel, Julien Haroche
No abstract text is available yet for this article.
August 23, 2023: Blood Advances
#34
Andrew S Blaeser, Jun Zhao, Arthur U Sugden, Simone Carneiro-Nascimento, Mark L Andermann, Dan Levy
Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-photon calcium imaging via a closed cranial window in awake mice to investigate changes in the responses of meningeal afferents using a preclinical model of migraine involving cortical spreading depolarization (CSD). A single CSD episode caused a seconds-long wave of calcium activation that propagated across afferents and along the length of individual afferents...
August 10, 2023: bioRxiv
#35
JOURNAL ARTICLE
Luba Tau, David Hagin, Tal Freund, Tamar Halperin, Amos Adler, Rotem Marom, Svetlana Ahsanov, Natasha Matus, Inbar Levi, Gal Gerber, Shir Lev, Tomer Ziv-Baran, Dan Turner
BACKGROUND: Recent studies have shown good serological and cellular immune responses in people living with human immunodeficiency virus ( PLWH) after receipt of 2 doses of messenger RNAA (mRNA) severe acute respiratory syndrome coronavirus 2 vaccine. Data are missing regarding the response after 3 vaccine doses. METHODS: We followed up a group of PLWH who received 3 doses of the mRNA BNT162b2 vaccine and for whom data of humoral immune response after 2 vaccine doses were available...
August 2023: Open Forum Infectious Diseases
#36
JOURNAL ARTICLE
Jun Zhao, Samantha Harrison, Dan Levy
Cortical spreading depolarization (CSD) is a key pathophysiological event that underlies visual and sensory auras in migraine. CSD is also thought to drive the headache phase in migraine by promoting the activation and mechanical sensitization of trigeminal primary afferent nociceptive neurons that innervate the cranial meninges. The factors underlying meningeal nociception in the wake of CSD remain poorly understood but potentially involve the parenchymal release of algesic mediators and damage-associated molecular patterns, particularly ATP...
July 24, 2023: Journal of Neuroscience
#37
JOURNAL ARTICLE
Nadav Frenkel, Einav Scharf, Gur Lubin, Adar Levi, Yossef E Panfil, Yonatan Ossia, Josep Planelles, Juan I Climente, Uri Banin, Dan Oron
Coupled colloidal quantum dot molecules (CQDMs) are an emerging class of nanomaterials, manifesting two coupled emission centers and thus introducing additional degrees of freedom for designing quantum-dot-based technologies. The properties of multiply excited states in these CQDMs are crucial to their performance as quantum light emitters, but they cannot be fully resolved by existing spectroscopic techniques. Here we study the characteristics of biexcitonic species, which represent a rich landscape of different configurations essentially categorized as either segregated or localized biexciton states...
August 8, 2023: ACS Nano
#38
Elio Riboli, Frederick A Beland, Dirk W Lachenmeier, M Matilde Marques, David H Phillips, Eva Schernhammer, Abdul Afghan, Ricardo Assunção, Giovanna Caderni, J Christopher Corton, Gisela de Aragão Umbuzeiro, Daphne de Jong, Melanie Deschasaux-Tanguy, Allison Hodge, Junko Ishihara, Dan D Levy, Daniele Mandrioli, Marjorie L McCullough, Sarah A McNaughton, Takeshi Morita, Anne P Nugent, Kumiko Ogawa, Arun R Pandiri, Consolato M Sergi, Mathilde Touvier, Luoping Zhang, Lamia Benbrahim-Tallaa, Shirisha Chittiboyina, Danila Cuomo, Nathan L DeBono, Charlotte Debras, Aline de Conti, Fatiha El Ghissassi, Emma Fontvieille, Rhea Harewood, John Kaldor, Heidi Mattock, Elisa Pasqual, Gabrielle Rigutto, Hannah Simba, Eero Suonio, Susana Viegas, Roland Wedekind, Mary K Schubauer-Berigan, Federica Madia
No abstract text is available yet for this article.
August 2023: Lancet Oncology
#39
JOURNAL ARTICLE
Dor Goshen, Daniel Stein, Jenny Kurman, Dan Farbstein, Adi Enoch-Levy, Erez Aival-Naveh, Eitan Gur, Neta Yoeli, Tali Bretler, Danny Koren, Lily Rothschild-Yakar
BACKGROUND: A large theoretical body of knowledge exists emphasizing the importance of parental mentalizing in the context of anorexia-nervosa (AN). However, the empirical support to these assumptions is still scarce. The aim of the present study was to examine whether parents of patients with AN are characterized by a lower mentalizing ability, and whether it is associated with impaired mentalizing, AN symptomatology and eating disorder (ED) related psychological traits in the daughters...
July 11, 2023: Journal of Eating Disorders
#40
JOURNAL ARTICLE
Gabriel Levy, Franziska Kocher, Grégoire Thuerig, Thomas Meszaros, Daniel Petek
An iron deficient athlete is likely to develop iron deficiency anemia, a pathology that may lead to a decrease in performance. If adult athletes, women and men, are aware of the need for regular monitoring, young people under 18 are not necessarily aware of the risks associated with competitive sports practice in the presence of anemia. Even if the guidelines are well known and described, a lack of regular monitoring is found for the aforementioned age group. In junior female athletes practicing basketball, a significant rate of iron deficiency or even iron deficiency anemia was found during annual analyses...
July 5, 2023: Revue Médicale Suisse
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