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JOURNAL ARTICLE
Hsiang-Po Huang, Chung-Hsin Chen, Kai-Hsiung Chang, Ming-Shyue Lee, Cheng-Fan Lee, Yen-Hsiang Chao, Shih-Yu Lu, Tzu-Fan Wu, Sung-Tzu Liang, Chih-Yu Lin, Yuan Chi Lin, Shih-Ping Liu, Yu-Chuan Lu, Chia-Tung Shun, William J Huang, Tzu-Ping Lin, Ming-Hsuan Ku, Hsiao-Jen Chung, Yen-Hwa Chang, Chun-Hou Liao, Chih-Chin Yu, Shiu-Dong Chung, Yao-Chou Tsai, Chia-Chang Wu, Kuan-Chou Chen, Chen-Hsun Ho, Pei-Wen Hsiao, Yeong-Shiau Pu
PURPOSE: Currently, there are no accurate markers for predicting potentially lethal prostate cancer (PC) before biopsy. This study aimed to develop urine tests to predict clinically significant PC (sPC) in men at risk. METHODS: Urine samples from 928 men, namely, 660 PC patients and 268 benign subjects, were analyzed by gas chromatography/quadrupole time-of-flight mass spectrophotometry (GC/Q-TOF MS) metabolomic profiling to construct four predictive models. Model I discriminated between PC and benign cases...
October 11, 2023: Journal of Translational Medicine
#22
JOURNAL ARTICLE
Geoffrey N Pronovost, Kristie B Yu, Elena J L Coley-O'Rourke, Sahil S Telang, Angela S Chen, Helen E Vuong, Drake W Williams, Anisha Chandra, Tomiko K Rendon, Jorge Paramo, Reuben H Kim, Elaine Y Hsiao
The maternal microbiome is an important regulator of gestational health, but how it affects the placenta as the interface between mother and fetus remains unexplored. Here, we show that the maternal gut microbiota supports placental development in mice. Depletion of the maternal gut microbiota restricts placental growth and impairs feto-placental vascularization. The maternal gut microbiota modulates metabolites in the maternal and fetal circulation. Short-chain fatty acids (SCFAs) stimulate cultured endothelial cell tube formation and prevent abnormalities in placental vascularization in microbiota-deficient mice...
October 6, 2023: Science Advances
#23
JOURNAL ARTICLE
Gabriela Baldeon Vaca, Michelle Meyer, Ana Cadete, Chiaowen Joyce Hsiao, Anne Golding, Albert Jeon, Eric Jacquinet, Emily Azcue, Chenxia Monica Guan, Xavier Sanchez-Felix, Colette A Pietzsch, Chad E Mire, Matthew A Hyde, Margaret E Comeaux, Julie M Williams, Jean C Sung, Andrea Carfi, Darin K Edwards, Alexander Bukreyev, Kapil Bahl
Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy of intranasally administered messenger RNA (mRNA)-lipid nanoparticle (LNP) encapsulated vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Syrian golden hamsters. Intranasal mRNA-LNP vaccination systemically induced spike-specific binding [immunoglobulin G (IgG) and IgA] and neutralizing antibodies...
September 22, 2023: Science Advances
#24
JOURNAL ARTICLE
Betty Hsiao, Julie S Downs, Mandy Lanyon, Susan J Blalock, Jeffrey R Curtis, Leslie R Harrold, William Benjamin Nowell, Carole Wiedmeyer, Shilpa Venkatachalam, Mark T Patterson, Kelly Gavigan, Laura Stradford, Danielle Ali, Liana Fraenkel
OBJECTIVE: Uptake of treat-to-target (TTT) strategies for rheumatoid arthritis (RA) management is low. Our objective was to understand the heterogeneity in patients' conceptualisation of RA treatment to inform interventions improving TTT uptake. DESIGN: Eligible participants recruited from an online research registry rated 56 items (on 5-point scales) reflecting concepts raised from patient interviews. Using items describing adhering to physician recommendations to create a binary criterion variable for medication adherence, we conducted a principal components analysis on the remaining items using Varimax rotation, describing how these factors predict adherence over and above demographic characteristics...
September 4, 2023: BMJ Open
#25
JOURNAL ARTICLE
Ruixue Lian, Vivian Hsiao, Juwon Hwang, Yue Ou, Sarah E Robbins, Nadine P Connor, Cameron L Macdonald, Rebecca S Sippel, William A Sethares, David F Schneider
BACKGROUND: Patient-reported outcomes (PRO) allow clinicians to measure health-related quality of life (HRQOL) and understand patients' treatment priorities, but obtaining PRO requires surveys which are not part of routine care. We aimed to develop a preliminary natural language processing (NLP) pipeline to extract HRQOL trajectory based on deep learning models using patient language. MATERIALS AND METHODS: Our data consisted of transcribed interviews of 100 patients undergoing surgical intervention for low-risk thyroid cancer, paired with HRQOL assessments completed during the same visits...
2023: Intelligence-based medicine
#26
JOURNAL ARTICLE
Spencer R Rosario, Bowen Dong, Yali Zhang, Hua-Hsin Hsiao, Emily Isenhart, Jianmin Wang, Erin M Siegel, Arta M Monjazeb, Dwight H Owen, Prasenjit Dey, Fred K Tabung, Daniel J Spakowicz, William J Murphy, Stephen Edge, Sai Yendamuri, Sami Ibrahimi, Jill M Kolesar, Patsy H McDonald, Deepak Vadehra, Michelle Churchman, Song Liu, Pawel Kalinski, Sarbajit Mukherjee
The prevalence of obesity, defined as the body mass index (BMI) ≥ 30 kg/m2 , has reached epidemic levels. Obesity is associated with an increased risk of various cancers, including gastrointestinal ones. Recent evidence has suggested that obesity disproportionately impacts males and females with cancer, resulting in varied transcriptional and metabolic dysregulation. This study aimed to elucidate the differences in the metabolic milieu of adenocarcinomas of the gastrointestinal (GI) tract both related and unrelated to sex in obesity...
June 29, 2023: International Journal of Molecular Sciences
#27
JOURNAL ARTICLE
Ping-Hsuan Yu, Tzu-Chun Wei, Yen-Hwa Chang, Hsiao-Jen Chung, Eric Yi-Hsiu Huang, Tzu-Ping Lin, William J Huang
BACKGROUND: Radium-223 (Ra-223), an α-particle-emitting isotope, inhibits bony metastases and prevents patients from skeletal-related events in metastatic castration-resistant prostate cancer (mCRPC). We retrospectively reviewed the treatment response, predictive factors, and adverse events (AEs) of Ra-223 prior to National Health Insurance reimbursement in a Taiwanese tertiary institute. METHODS: Patients treated with Ra-223 before January 2019 were enrolled and categorized into progressive disease (PD) and clinical benefits (CB) groups...
June 14, 2023: Journal of the Chinese Medical Association: JCMA
#28
JOURNAL ARTICLE
Eric Yi-Hsiu Huang, Meng-Che Tai, Hsiao-Jen Chung, Yen-Hwa Chang, William J Huang
PURPOSE: To compare the effects of different combinations of radical nephroureterectomy (RNU) and bladder cuff excision (BCE) surgical procedures on intravesical recurrence (IVR) in patients with upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: This retrospective observational study included 452 patients who underwent RNU with BCE for UTUC between January 2010 and December 2020. The patients were classified into three groups based on different combinations of RNU and BCE surgical procedures: open RNU with open BCE (group 1, n=104), minimally invasive (MIS) RNU with open BCE (group 2, n=196), and MIS RNU with intracorporeal BCE (group 3, n=152)...
2023: International Braz J Urol: Official Journal of the Brazilian Society of Urology
#29
JOURNAL ARTICLE
Damion Dooley, Matthew H Nguyen, William W L Hsiao
An application ontology often reuses terms from other related, compatible ontologies. The extent of this interconnectedness is not readily apparent when browsing through larger textual presentations of term class hierarchies, be it Manchester text format OWL files or within an ontology editor like Protege. Users must either note ontology sources in term identifiers, or look at ontology import file term origins. Diagrammatically, this same information may be easier to perceive in 2 dimensional network or hierarchical graphs that visually code ontology term origins...
2023: PloS One
#30
JOURNAL ARTICLE
Dong-Joo Choi, Georgina Armstrong, Brittney Lozzi, Prashanth Vijayaraghavan, Sharon E Plon, Terence C Wong, Eric Boerwinkle, Donna M Muzny, Hsiao-Chi Chen, Richard A Gibbs, Quinn T Ostrom, Beatrice Melin, Benjamin Deneen, Melissa L Bondy, Matthew N Bainbridge, Christopher I Amos, Jill S Barnholtz-Sloan, Jonine L Bernstein, Elizabeth B Claus, Richard S Houlston, Dora Il'yasova, Robert B Jenkins, Christoffer Johansen, Daniel Lachance, Rose Lai, Beatrice S Melin, Ryan T Merrell, Sara H Olson, Siegal Sadetzki, Joellen Schildkraut, Sanjay Shete, J C Ambrose, P Arumugam, R Bevers, M Bleda, F Boardman-Pretty, C R Boustred, H Brittain, M A Brown, M J Caulfield, G C Chan, A Giess, J N Griffin, A Hamblin, S Henderson, T J P Hubbard, R Jackson, L J Jones, D Kasperaviciute, M Kayikci, A Kousathanas, L Lahnstein, A Lakey, S E A Leigh, I U S Leong, F J Lopez, F Maleady-Crowe, M McEntagart, F Minneci, J Mitchell, L Moutsianas, M Mueller, N Murugaesu, A C Need, P O'Donovan, C A Odhams, C Patch, D Perez-Gil, M B Pereira, J Pullinger, T Rahim, A Rendon, T Rogers, K Savage, K Sawant, R H Scott, A Siddiq, A Sieghart, S C Smith, A Sosinsky, A Stuckey, M Tanguy, A L Taylor Tavares, E R A Thomas, S R Thompson, A Tucci, M J Welland, E Williams, K Witkowska, S M Wood, M Zarowiecki
Glioma is a rare brain tumor with a poor prognosis. Familial glioma is a subset of glioma with a strong genetic predisposition that accounts for approximately 5% of glioma cases. We performed whole-genome sequencing on an exploratory cohort of 203 individuals from 189 families with a history of familial glioma and an additional validation cohort of 122 individuals from 115 families. We found significant enrichment of rare deleterious variants of seven genes in both cohorts, and the most significantly enriched gene was HERC2 ( P = 0...
April 28, 2023: Science Advances
#31
JOURNAL ARTICLE
Fedor Romanov-Michailidis, Chien-Chi Hsiao, Lorenz M Urner, Soufyan Jerhaoui, Michel Surkyn, Bradley Miller, Ann Vos, Maria Dominguez Blanco, Ruud Bueters, Petra Vinken, Mariette Bekkers, David Walker, Beth Pietrak, Werner Eyckmans, José Luís Dores-Sousa, Seong Joo Koo, William Lento, Marcus Bauser, Ulrike Philippar, Frederik J R Rombouts
Avoidance of apoptosis is critical for the development and sustained growth of tumors. The pro-survival protein myeloid cell leukemia 1 (Mcl-1) is an anti-apoptotic member of the Bcl-2 family of proteins which is overexpressed in many cancers. Upregulation of Mcl-1 in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy. Therefore, pharmacological inhibition of Mcl-1 is regarded as an attractive approach to treating relapsed or refractory malignancies. Herein, we disclose the design, synthesis, optimization, and early preclinical evaluation of a potent and selective small-molecule inhibitor of Mcl-1...
April 28, 2023: Journal of Medicinal Chemistry
#32
EDITORIAL
Yan-Gao Man, Ciaran Mannion, Alexander Stojadinovic, George E Peoples, William Cs Cho, Sidney W Fu, Xiaohui Tan, Yi-Hsuan Hsiao, Aijun Liu, Andrzej Semczuk, Paul Zarogoulidis, Andrei B Gapeev, Xiyun Deng, Xiaoning Peng, Boris A Reva, Tatiana Omelchenko, Jialian Wang, Guohong Song, Tingtao Chen
Breast cancer development and progression are believed to be a sequential process, from normal to hyperplastic, to in situ , and to invasive and metastatic stages. Given that over 90% of cancer deaths are caused by invasive and metastatic lesions, countless factors and multiple theories have been proposed as the triggering factor for the cascade of actions of cancer invasion. However, those factors and theories are largely based on the studies of cell lines or animal models. In addition, corresponding interventions based on these factors and theories have failed to reduce the incidence rate of invasive and metastatic lesions, suggesting that previous efforts may have failed to arm at the right target...
2023: Journal of Cancer
#33
Melina L Corriveau, Sabrina I Amaya, Mary Clare Koebel, Vanesa C Lerma, Sydney L Michener, Alicia Turner, Rebecca J Schultz, Elaine S Seto, Gloria E Diaz-Medina, William J Craigen, John W Swann, Mingshan Xue, Hsiao-Tuan Chao
The p-21-activated kinase 1 (PAK1) protein, encoded by the PAK1 gene, is an evolutionarily conserved serine/threonine-protein kinase that regulates key cellular developmental processes. To date, seven de novo PAK1 variants have been reported to cause the Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech Delay (IDDMSSD). In addition to the namesake features, other common characteristics include structural brain anomalies, delayed development, hypotonia, and dysmorphic features. Here, we report a de novo PAK1 NM_002576...
March 10, 2023: American Journal of Medical Genetics. Part A
#34
JOURNAL ARTICLE
Alexandra Bishop, Hsiao-Hsuan Wang, Taylor G Donaldson, Emily E Brockinton, Esha Kothapalli, Scott Clark, Tanvi Vishwanath, Tatyana Canales, Krishnendu Sreekumar, William E Grant, Pete D Teel
Tularemia is a rare but potentially serious bacterial zoonosis, which has been reported in the 47 contiguous states of the USA during 2001-2010. This report summarizes the passive surveillance data of tularemia cases reported to the Centers for Disease Control and Prevention from 2011 through 2019. There were 1984 cases reported in the USA during this period. The average national incidence was 0.07 cases per 100,000 person-years (PY), compared to 0.04 cases per 100,000 PY during 2001-2010. The highest statewide reported case 2011-2019 was in Arkansas (374 cases, 20...
2023: Curr Res Parasitol Vector Borne Dis
#35
Geoffrey N Pronovost, Sahil S Telang, Angela S Chen, Elena J L Coley, Helen E Vuong, Drake W Williams, Kristie B Yu, Tomiko K Rendon, Jorge Paramo, Reuben H Kim, Elaine Y Hsiao
The maternal microbiome is an important regulator of gestational health, but how it impacts the placenta as the interface between mother and fetus remains unexplored. Here we show that the maternal gut microbiota supports placental development in mice. Depletion of the maternal gut microbiota restricts placental growth and impairs feto-placental vascularization. The maternal gut microbiota modulates metabolites in the maternal and fetal circulation. Short-chain fatty acids (SCFAs) stimulate angiogenesis-related tube formation by endothelial cells and prevent abnormalities in placental vascularization in microbiota-deficient mice...
February 15, 2023: bioRxiv
#36
JOURNAL ARTICLE
William C Hsiao
No abstract text is available yet for this article.
March 2023: Social Science & Medicine
#37
JOURNAL ARTICLE
William C Hsiao, Winnie Yip
The international consensus in support of universal health coverage (UHC), though commendable, thus far lacks a clear mechanism to finance and deliver accessible and effective basic healthcare to the two billion rural residents and informal workers of low- and lower-middle-income countries (LLMICs). Importantly, the two preferred financing modes for UHC, general tax revenue and social health insurance, are often infeasible for LLMICs. We identify from historical examples a community-based model that we argue shows promise as a solution to this problem...
February 9, 2023: Social Science & Medicine
#38
Scott Russo, Flurin Cathomas, Hsiao-Yun Lin, Kenny Chan, Long Li, Romain Durand-de Cuttoli, Lyonna Parise, Antonio Aubry, Samer Muhareb, Fiona Desland, Yusuke Shimo, Aarthi Ramakrishnan, Molly Estill, Carmen Ferrer-Perez, Eric Parise, Jun Wang, Allison Sowa, William Janssen, Sara Costi, Adeeb Rahman, Nicolas Fernandez, Filip Swirski, Eric Nestler, Li Shen, Miriam Merad, James Murrough
Psychosocial stress has profound effects on the body, including the peripheral immune system and the brain1,2. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD)3,4,5, the underlying mechanisms are not well understood. Here we show that a peripheral myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is elevated in serum of subjects with MDD as well as in stress-susceptible (SUS) mice following chronic social defeat stress (CSDS)...
January 30, 2023: Research Square
#39
JOURNAL ARTICLE
Philipa Mladovsky, Ruth Prince, Fatoumata Hane, Valéry Ridde
No abstract text is available yet for this article.
January 28, 2023: Social Science & Medicine
#40
JOURNAL ARTICLE
Sarah A Savic Kallesoe, Tian Rabbani, Erin E Gill, Fiona Brinkman, Emma J Griffiths, Ma'n Zawati, Hanshi Liu, Nicole Palmour, Yann Joly, William W L Hsiao
OBJECTIVES: COVID-19 research has significantly contributed to pandemic response and the enhancement of public health capacity. COVID-19 data collected by provincial/territorial health authorities in Canada are valuable for research advancement yet not readily available to the public, including researchers. To inform developments in public health data-sharing in Canada, we explored Canadians' opinions of public health authorities sharing deidentified individual-level COVID-19 data publicly...
February 7, 2023: BMJ Open
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