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William Hsiao

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https://www.readbyqxmd.com/read/28253632/nickel-catalyzed-synthesis-of-quinazolinediones
#1
Gregory L Beutner, Yi Hsiao, Thomas Razler, Eric M Simmons, William Wertjes
A nickel(0)-catalyzed method for the synthesis of quinazolinediones from isatoic anhydrides and isocyanates is described. High-throughput ligand screening revealed that XANTPHOS was the optimal ligand for this transformation. Subsequent optimization studies, supported by kinetic analysis, significantly expanded the reaction scope. The reaction exhibits a case of substrate inhibition kinetics with respect to the isocyanate. Preliminary results on an asymmetric synthesis of atropisomeric quinazolinediones are reported...
March 3, 2017: Organic Letters
https://www.readbyqxmd.com/read/28240221/mammalian-trappiii-complex-positively-modulates-the-recruitment-of-sec13-31-onto-copii-vesicles
#2
Shan Zhao, Chun Man Li, Xiao Min Luo, Gavin Ka Yu Siu, Wen Jia Gan, Lin Zhang, William K K Wu, Hsiao Chang Chan, Sidney Yu
The Transport protein particle (TRAPP) complex is a tethering factor for COPII vesicle. Of three forms of TRAPP (TRAPPI, II and III) complexes identified so far, TRAPPIII has been largely considered to play a role in autophagy. While depletion of TRAPPIII specific subunits caused defects in the early secretory pathway and TRAPPIII might interact with components of the COPII vesicle coat, its exact role remains to be determined. In this study, we studied the function of TRAPPIII in early secretory pathway using a TRAPPIII-specific subunit, TRAPPC12, as starting point...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28159067/infection-control-in-the-new-age-of-genomic-epidemiology
#3
REVIEW
Patrick Tang, Matthew A Croxen, Mohammad R Hasan, William W L Hsiao, Linda M Hoang
With the growing importance of infectious diseases in health care and communicable disease outbreaks garnering increasing attention, new technologies are playing a greater role in helping us prevent health care-associated infections and provide optimal public health. The microbiology laboratory has always played a large role in infection control by providing tools to identify, characterize, and track pathogens. Recently, advances in DNA sequencing technology have ushered in a new era of genomic epidemiology, where traditional molecular diagnostics and genotyping methods are being enhanced and even replaced by genomics-based methods to aid epidemiologic investigations of communicable diseases...
February 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28110250/detection-and-discrimination-of-maintenance-and-de-novo-cpg-methylation-events-using-methylbreak
#4
William Hsu, Augustus T Mercado, George Hsiao, Jui-Ming Yeh, Chung-Yung Chen
Understanding the principles governing the establishment and maintenance activities of DNA methyltransferases (DNMTs) can help in the development of predictive biomarkers associated with genetic disorders and diseases. A detection system was developed that distinguishes and quantifies methylation events using methylation-sensitive endonucleases and molecular beacon technology. MethylBreak (MB) is a 22-mer oligonucleotide with one hemimethylated and two unmethylated CpG sites, which are also recognition sites for Sau96I and SacII, and is attached to a fluorophore and a quencher...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28017372/a-syndromic-neurodevelopmental-disorder-caused-by-de-novo-variants-in-ebf3
#5
Hsiao-Tuan Chao, Mariska Davids, Elizabeth Burke, John G Pappas, Jill A Rosenfeld, Alexandra J McCarty, Taylor Davis, Lynne Wolfe, Camilo Toro, Cynthia Tifft, Fan Xia, Nicholas Stong, Travis K Johnson, Coral G Warr, Shinya Yamamoto, David R Adams, Thomas C Markello, William A Gahl, Hugo J Bellen, Michael F Wangler, May Christine V Malicdan
Early B cell factor 3 (EBF3) is a member of the highly evolutionarily conserved Collier/Olf/EBF (COE) family of transcription factors. Prior studies on invertebrate and vertebrate animals have shown that EBF3 homologs are essential for survival and that loss-of-function mutations are associated with a range of nervous system developmental defects, including perturbation of neuronal development and migration. Interestingly, aristaless-related homeobox (ARX), a homeobox-containing transcription factor critical for the regulation of nervous system development, transcriptionally represses EBF3 expression...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27914715/prostate-cancer-in-young-adults-seventeen-year-clinical-experience-of-a-single-center
#6
Tzu-Hao Huang, Junne-Yih Kuo, Yi-Hsiu Huang, Hsiao-Jen Chung, William J S Huang, Howard H H Wu, Yen-Hwa Chang, Alex T L Lin, Kuang-Kuo Chen
BACKGROUND: In the general population, prostate adenocarcinoma affects predominately older men. If fact, most current guidelines suggest that males over the age of 50 years should undergo prostate cancer screening. However, the clinical behavior and prognosis of prostate cancer in young adults is not well defined. The aim of this study was to evaluate the clinical behavior, pathological characteristics, and prognosis of prostate cancer in young adults. METHODS: We retrospectively reviewed the records of young patients (age, ≤50 years) in our hospital with prostate adenocarcinoma between 1997 and 2013...
January 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27903913/functional-rnas-combined-assembly-and-packaging-in-vlps
#7
Po-Yu Fang, Lizzette M Gómez Ramos, Stefany Y Holguin, Chiaolong Hsiao, Jessica C Bowman, Hung-Wei Yang, Loren Dean Williams
We describe here a one pot RNA production, packaging and delivery system based on bacteriophage Qβ. We demonstrate a method for production of a novel RNAi scaffold, packaged within Qβ virus-like particles (VLPs). The RNAi scaffold is a general utility chimera that contains a functional RNA duplex with paired silencing and carrier sequences stabilized by a miR-30 stem-loop. The Qβ hairpin on the 5' end confers affinity for the Qβ coat protein (CP). Silencing sequences can include mature miRNAs and siRNAs, and can target essentially any desired mRNA...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27881825/effects-of-a-gut-pathobiont-in-a-gnotobiotic-mouse-model-of-childhood-undernutrition
#8
Vitas E Wagner, Neelendu Dey, Janaki Guruge, Ansel Hsiao, Philip P Ahern, Nicholas P Semenkovich, Laura V Blanton, Jiye Cheng, Nicholas Griffin, Thaddeus S Stappenbeck, Olga Ilkayeva, Christopher B Newgard, William Petri, Rashidul Haque, Tahmeed Ahmed, Jeffrey I Gordon
To model how interactions among enteropathogens and gut microbial community members contribute to undernutrition, we colonized gnotobiotic mice fed representative Bangladeshi diets with sequenced bacterial strains cultured from the fecal microbiota of two 24-month-old Bangladeshi children: one healthy and the other underweight. The undernourished donor's bacterial collection contained an enterotoxigenic Bacteroides fragilis strain (ETBF), whereas the healthy donor's bacterial collection contained two nontoxigenic strains of B...
November 23, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27806082/metagenomic-investigation-of-plasma-in-individuals-with-me-cfs-highlights-the-importance-of-technical-controls-to-elucidate-contamination-and-batch-effects
#9
Ruth R Miller, Miguel Uyaguari-Diaz, Mark N McCabe, Vincent Montoya, Jennifer L Gardy, Shoshana Parker, Theodore Steiner, William Hsiao, Matthew J Nesbitt, Patrick Tang, David M Patrick
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease causing indefinite fatigue. ME/CFS has long been hypothesised to have an infectious cause; however, no specific infectious agent has been identified. We used metagenomics to analyse the RNA from plasma samples from 25 individuals with ME/CFS and compare their microbial content to technical controls as well as three control groups: individuals with alternatively diagnosed chronic Lyme syndrome (N = 13), systemic lupus erythematosus (N = 11), and healthy controls (N = 25)...
2016: PloS One
https://www.readbyqxmd.com/read/27627042/dermatology-and-possession
#10
Chu Hsiao, Eric Laurent Maranda, William A Estes, Gabriela M Soza, Keyvan Nouri
No abstract text is available yet for this article.
September 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27537774/visceral-leishmaniasis-on-the-indian-subcontinent-modelling-the-dynamic-relationship-between-vector-control-schemes-and-vector-life-cycles
#11
David M Poché, William E Grant, Hsiao-Hsuan Wang
BACKGROUND: Visceral leishmaniasis (VL) is a disease caused by two known vector-borne parasite species (Leishmania donovani, L. infantum), transmitted to man by phlebotomine sand flies (species: Phlebotomus and Lutzomyia), resulting in ≈50,000 human fatalities annually, ≈67% occurring on the Indian subcontinent. Indoor residual spraying is the current method of sand fly control in India, but alternative means of vector control, such as the treatment of livestock with systemic insecticide-based drugs, are being evaluated...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27491287/cost-effectiveness-of-granulocyte-colony-stimulating-factor-prophylaxis-in-chemotherapy-induced-febrile-neutropenia-among-breast-cancer-and-non-hodgkin-s-lymphoma-patients-under-taiwan-s-national-health-insurance-system
#12
Tsun-Jen Wen, Yu-Wen Wen, Chun-Ru Chien, Shao-Chin Chiang, William Wei-Yuan Hsu, Li-Jiuan Shen, Fei-Yuan Hsiao
RATIONALE, AIM AND OBJECTIVE: The beneficial effects of granulocyte colony-stimulating factor (G-CSF) prophylaxis on reducing the risk of chemotherapy-induced febrile neutropenia (CIFN) were well documented throughout the literature. However, existing data regarding its cost-effectiveness were conflicting. We estimated the cost-effectiveness of G-CSF prophylaxis in CIFN under Taiwan's National Health Insurance (NHI) system. METHODS: Data on clinical outcomes and direct medical costs were derived for 5179 newly diagnosed breast cancer and 629 non-Hodgkin's lymphoma (NHL) patients from the NHI claims database...
August 4, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27362227/allosteric-inhibition-of-shp2-phosphatase-inhibits-cancers-driven-by-receptor-tyrosine-kinases
#13
Ying-Nan P Chen, Matthew J LaMarche, Ho Man Chan, Peter Fekkes, Jorge Garcia-Fortanet, Michael G Acker, Brandon Antonakos, Christine Hiu-Tung Chen, Zhouliang Chen, Vesselina G Cooke, Jason R Dobson, Zhan Deng, Feng Fei, Brant Firestone, Michelle Fodor, Cary Fridrich, Hui Gao, Denise Grunenfelder, Huai-Xiang Hao, Jaison Jacob, Samuel Ho, Kathy Hsiao, Zhao B Kang, Rajesh Karki, Mitsunori Kato, Jay Larrow, Laura R La Bonte, Francois Lenoir, Gang Liu, Shumei Liu, Dyuti Majumdar, Matthew J Meyer, Mark Palermo, Lawrence Perez, Minying Pu, Edmund Price, Christopher Quinn, Subarna Shakya, Michael D Shultz, Joanna Slisz, Kavitha Venkatesan, Ping Wang, Markus Warmuth, Sarah Williams, Guizhi Yang, Jing Yuan, Ji-Hu Zhang, Ping Zhu, Timothy Ramsey, Nicholas J Keen, William R Sellers, Travis Stams, Pascal D Fortin
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor signalling and was the first reported oncogenic tyrosine phosphatase. Activating mutations of SHP2 have been associated with developmental pathologies such as Noonan syndrome and are found in multiple cancer types, including leukaemia, lung and breast cancer and neuroblastoma. SHP2 is ubiquitously expressed and regulates cell survival and proliferation primarily through activation of the RAS–ERK signalling pathway...
July 7, 2016: Nature
https://www.readbyqxmd.com/read/27016234/molecular-classification-of-high-grade-endometrioid-and-clear-cell-ovarian-cancer-using-tcga-gene-expression-signatures
#14
Boris Winterhoff, Habib Hamidi, Chen Wang, Kimberly R Kalli, Brooke L Fridley, Judy Dering, Hsiao-Wang Chen, William A Cliby, He-Jing Wang, Sean Dowdy, Bobbie S Gostout, Gary L Keeney, Ellen L Goode, Gottfried E Konecny
BACKGROUND: It is unclear whether the transcriptional subtypes of high grade serous ovarian cancer (HGSOC) apply to high grade clear cell (HGCCOC) or high grade endometrioid ovarian cancer (HGEOC). We aim to delineate transcriptional profiles of HGCCOCs and HGEOCs. METHODS: We used Agilent microarrays to determine gene expression profiles of 276 well annotated ovarian cancers (OCs) including 37 HGCCOCs and 66 HGEOCs. We excluded low grade OCs as these are known to be distinct molecular entities...
April 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/26974368/caring-for-coronary-artery-disease-in-china-managing-modernization
#15
COMMENT
David Blumenthal, William Hsiao, Daniel M Blumenthal
No abstract text is available yet for this article.
April 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/26970558/mechanistic-study-of-the-anti-cancer-effect-of-gynostemma-pentaphyllum-saponins-in-the-apc-min-mouse-model
#16
William Chi-Shing Tai, Wing-Yan Wong, Magnolia Muk-Lan Lee, Brandon Dow Chan, Cheng Lu, Wen-Luan Wendy Hsiao
Gynostemma pentaphyllum saponins (GpS) have been shown to have anti-cancer activity. However, the underlying mechanisms remain unclear. In this study, we used the Apc(Min) (/+) colorectal cancer (CRC) mouse model to investigate the anti-cancer effect of GpS and we demonstrated that GpS treatment could significantly reduce the number and size of intestinal polyps in Apc(Min) (/+) mice. In order to identify the potential targets and mechanisms involved, a comparative proteomics analysis was performed and 40 differentially expressed proteins after GpS treatment were identified...
May 2016: Proteomics
https://www.readbyqxmd.com/read/26903488/range-expansion-of-invasive-shrubs-implication-for-crown-fire-risk-in-forestlands-of-the-southern-usa
#17
Hsiao-Hsuan Wang, Carissa L Wonkka, William E Grant, William E Rogers
Non-native plant invasions and changing management activities have dramatically altered the structure and composition of forests worldwide. Invasive shrubs and fire suppression have led to increased densification and biomass accumulation in forest ecosystems of the southeastern USA. Notably, Chinese and European privets are rapid growing, shade-tolerant shrubs which number among the most aggressive invasive species in these forests. Privet encroachment has caused losses of native diversity, alteration of ecosystem processes and changes in community structure...
2016: AoB Plants
https://www.readbyqxmd.com/read/26873713/identifying-the-effect-of-patient-sharing-on-between-hospital-genetic-differentiation-of-methicillin-resistant-staphylococcus-aureus
#18
Hsiao-Han Chang, Janina Dordel, Tjibbe Donker, Colin J Worby, Edward J Feil, William P Hanage, Stephen D Bentley, Susan S Huang, Marc Lipsitch
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient sharing on MRSA transmission, a previous study collected 2,214 samples from 30 hospitals in Orange County, California and showed by spa typing that genetic differentiation decreased significantly with increased patient sharing. In the current study, we focused on the 986 samples with spa type t008 from the same population...
February 13, 2016: Genome Medicine
https://www.readbyqxmd.com/read/26828895/triclosan-tcs-exposure-impairs-lipid-metabolism-in-zebrafish-embryos
#19
Jeff C H Ho, C D Hsiao, K Kawakami, William K F Tse
Triclosan (TCS) is an active antimicrobial ingredient used in many household products, such as skin creams and toothpaste. It is produced in high volumes, and humans are directly exposed to it and dispose it on a daily basis. TCS has been found to contaminate water worldwide. This study aimed to understand the potential developmental and metabolic abnormalities caused by TCS exposure by using zebrafish as the experimental model. Four developmental stages (70-85% epiboly, 10-12 somite, prim-5, and 5dpf) were selected to perform in situ hybridization staining to investigate the effects of TCS on dorsal ventral patterning, segmentation, brain development, and organ formation...
April 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/26732429/meta-analysis-of-genome-wide-association-studies-identifies-multiple-lung-cancer-susceptibility-loci-in-never-smoking-asian-women
#20
Zhaoming Wang, Wei Jie Seow, Kouya Shiraishi, Chao A Hsiung, Keitaro Matsuo, Jie Liu, Kexin Chen, Taiki Yamji, Yang Yang, I-Shou Chang, Chen Wu, Yun-Chul Hong, Laurie Burdett, Kathleen Wyatt, Charles C Chung, Shengchao A Li, Meredith Yeager, Amy Hutchinson, Wei Hu, Neil Caporaso, Maria T Landi, Nilanjan Chatterjee, Minsun Song, Joseph F Fraumeni, Takashi Kohno, Jun Yokota, Hideo Kunitoh, Kyota Ashikawa, Yukihide Momozawa, Yataro Daigo, Tetsuya Mitsudomi, Yasushi Yatabe, Toyoaki Hida, Zhibin Hu, Juncheng Dai, Hongxia Ma, Guangfu Jin, Bao Song, Zhehai Wang, Sensen Cheng, Zhihua Yin, Xuelian Li, Yangwu Ren, Peng Guan, Jiang Chang, Wen Tan, Chien-Jen Chen, Gee-Chen Chang, Ying-Huang Tsai, Wu-Chou Su, Kuan-Yu Chen, Ming-Shyan Huang, Yuh-Min Chen, Hong Zheng, Haixin Li, Ping Cui, Huan Guo, Ping Xu, Li Liu, Motoki Iwasaki, Taichi Shimazu, Shoichiro Tsugane, Junjie Zhu, Gening Jiang, Ke Fei, Jae Yong Park, Yeul Hong Kim, Jae Sook Sung, Kyong Hwa Park, Young Tae Kim, Yoo Jin Jung, Chang Hyun Kang, In Kyu Park, Hee Nam Kim, Hyo-Sung Jeon, Jin Eun Choi, Yi Young Choi, Jin Hee Kim, In-Jae Oh, Young-Chul Kim, Sook Whan Sung, Jun Suk Kim, Ho-Il Yoon, Sun-Seog Kweon, Min-Ho Shin, Adeline Seow, Ying Chen, Wei-Yen Lim, Jianjun Liu, Maria Pik Wong, Victor Ho Fun Lee, Bryan A Bassig, Margaret Tucker, Sonja I Berndt, Wong-Ho Chow, Bu-Tian Ji, Junwen Wang, Jun Xu, Alan Dart Loon Sihoe, James C M Ho, John K C Chan, Jiu-Cun Wang, Daru Lu, Xueying Zhao, Zhenhong Zhao, Junjie Wu, Hongyan Chen, Li Jin, Fusheng Wei, Guoping Wu, She-Juan An, Xu-Chao Zhang, Jian Su, Yi-Long Wu, Yu-Tang Gao, Yong-Bing Xiang, Xingzhou He, Jihua Li, Wei Zheng, Xiao-Ou Shu, Qiuyin Cai, Robert Klein, William Pao, Charles Lawrence, H Dean Hosgood, Chin-Fu Hsiao, Li-Hsin Chien, Ying-Hsiang Chen, Chung-Hsing Chen, Wen-Chang Wang, Chih-Yi Chen, Chih-Liang Wang, Chong-Jen Yu, Hui-Ling Chen, Yu-Chun Su, Fang-Yu Tsai, Yi-Song Chen, Yao-Jen Li, Tsung-Ying Yang, Chien-Chung Lin, Pan-Chyr Yang, Tangchun Wu, Dongxin Lin, Baosen Zhou, Jinming Yu, Hongbing Shen, Michiaki Kubo, Stephen J Chanock, Nathaniel Rothman, Qing Lan
Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21...
February 1, 2016: Human Molecular Genetics
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