Sandra Romero-Hidalgo, José Flores-Rivera, Verónica Rivas-Alonso, Rodrigo Barquera, María Teresa Villarreal-Molina, Bárbara Antuna-Puente, Luis Rodrigo Macias-Kauffer, Marisela Villalobos-Comparán, Jair Ortiz-Maldonado, Neng Yu, Tatiana V Lebedeva, Sharon M Alosco, Juan Daniel García-Rodríguez, Carolina González-Torres, Sandra Rosas-Madrigal, Graciela Ordoñez, Jorge Luis Guerrero-Camacho, Irene Treviño-Frenk, Monica Escamilla-Tilch, Maricela García-Lechuga, Víctor Hugo Tovar-Méndez, Hanna Pacheco-Ubaldo, Victor Acuña-Alonzo, Maria-Cátira Bortolini, Carla Gallo, Gabriel Bedoya, Francisco Rothhammer, Rolando González-Jose, Andrés Ruiz-Linares, Samuel Canizales-Quinteros, Edmond Yunis, Julio Granados, Teresa Corona
Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68...
August 13, 2020: Scientific Reports