Oliver L Eichmüller, Nina S Corsini, Ábel Vértesy, Ilaria Morassut, Theresa Scholl, Victoria-Elisabeth Gruber, Angela M Peer, Julia Chu, Maria Novatchkova, Johannes A Hainfellner, Mercedes F Paredes, Martha Feucht, Jürgen A Knoblich
Evolutionary development of the human brain is characterized by the expansion of various brain regions. Here, we show that developmental processes specific to humans are responsible for malformations of cortical development (MCDs), which result in developmental delay and epilepsy in children. We generated a human cerebral organoid model for tuberous sclerosis complex (TSC) and identified a specific neural stem cell type, caudal late interneuron progenitor (CLIP) cells. In TSC, CLIP cells over-proliferate, generating excessive interneurons, brain tumors, and cortical malformations...
January 28, 2022: Science