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https://www.readbyqxmd.com/read/29679631/possible-early-detection-of-coronary-artery-calcium-progression-in-type-1-diabetes-a-case-control-study-of-normoalbuminuric-type-1-diabetes-patients-and-matched-controls
#1
Henrik Ø Hjortkjær, Tonny Jensen, Jannik Hilsted, Helle Corinth, Ulrik M Mogensen, Lars Køber, Andreas Fuchs, Børge G Nordestgaard, Klaus F Kofoed
AIMS: Coronary artery calcium (CAC) is associated with cardiovascular (CV) disease and progression of CAC is an independent predictor of mortality. Type 1 diabetes is associated with increased CV risk, especially in persons with cardiovascular autonomic neuropathy (CAN). This study aimed to examine whether short-term progression of CAC is increased in persons with type 1 diabetes compared to matched controls and if CAN increases risk of CAC progression. METHODS: Fifty-three normoalbuminuric persons with long-term type 1 diabetes (20 with CAN) were matched in a 1:2 ratio with 106 controls without diabetes according to age, sex and baseline CAC...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29674364/health-and-prevention-enhancement-h-peace-a-retrospective-population-based-cohort-study-conducted-at-the-seoul-national-university-hospital-gangnam-center-korea
#2
Changhyun Lee, Eun Kyung Choe, Ji Min Choi, Yunji Hwang, Young Lee, Boram Park, Su Jin Chung, Min-Sun Kwak, Jong-Eun Lee, Joo Sung Kim, Sue Kyung Park, Sang-Heon Cho
PURPOSE: The Health and Prevention Enhancement (H-PEACE) study was designed to investigate the association of diagnostic imaging results, biomarkers and the predisease stage of non-communicable diseases (NCDs), such as malignancies and metabolic diseases, in an average-risk population in Korea. PARTICIPANTS: This study enrolled a large-scale retrospective cohort at the Healthcare System Gangnam Center, Seoul National University Hospital, from October 2003 to December 2014...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29667200/treatment-in-a-preventive-cardiology-clinic-utilizing-advanced-practice-providers-apps-effectively-closes-atherosclerotic-cardiovascular-disease-ascvd-risk-management-gaps-amongst-a-primary-prevention-population-compared-with-a-propensity-matched-primary-care
#3
Emilio Fentanes, Anthony G Vande Hei, R Scott Holuby, Norma Suarez, Yousif Slim, Jennifer N Slim, Ahmad M Slim, Dustin Thomas
BACKGROUND: Advanced Practice Providers (APPs) can fill access to care gaps created by physician shortages and improve adherence/compliance with preventive atherosclerotic cardiovascular disease (ASCVD) interventions. METHODS: We retrospectively reviewed data on 595 patients enrolled in a preventive cardiology clinic (PCC) utilizing APPs compared with a propensity-matched cohort (PMC) of 595 patients enrolled in primary care clinics alone. PCC patients were risk stratified using Framingham risk scoring (FRS) and coronary artery calcium scoring (CACS) and treated based on published guideline-based algorithms...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29627375/longer-diabetes-duration-reduces-myocardial-blood-flow-in-remote-myocardium-assessed-by-dynamic-myocardial-ct-perfusion
#4
Nobuo Tomizawa, Yusuke Fujino, Masaru Kamitani, Shengpu Chou, Kodai Yamamoto, Shinichi Inoh, Takeshi Nojo, Sunao Nakamura
AIMS: To investigate the relationship of type 2 diabetes duration and myocardial blood flow (MBF) assessed by myocardial CT perfusion. MATERIALS AND METHODS: We prospectively included 140 patients with type 2 diabetes who underwent dynamic myocardial CT perfusion exam. MBF of the remote myocardium was calculated using the deconvolution technique and the Voronoi method. The relationships of MBF and diabetic duration, diabetic complications, conventional risk factors, coronary calcium, and coronary stenosis were assessed by logistic regression analysis...
March 16, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29625564/urinary-proteomics-for-prediction-of-mortality-in-patients-with-type-2-diabetes-and-microalbuminuria
#5
Gemma E Currie, Bernt Johan von Scholten, Sheon Mary, Jose-Luis Flores Guerrero, Morten Lindhardt, Henrik Reinhard, Peter K Jacobsen, William Mullen, Hans-Henrik Parving, Harald Mischak, Peter Rossing, Christian Delles
BACKGROUND: The urinary proteomic classifier CKD273 has shown promise for prediction of progressive diabetic nephropathy (DN). Whether it is also a determinant of mortality and cardiovascular disease in patients with microalbuminuria (MA) is unknown. METHODS: Urine samples were obtained from 155 patients with type 2 diabetes and confirmed microalbuminuria. Proteomic analysis was undertaken using capillary electrophoresis coupled to mass spectrometry to determine the CKD273 classifier score...
April 6, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29622969/relationship-between-serum-osteoprotegerin-and-vascular-calcifications-in-hemodialysis-patients
#6
Tarek Z El Baz, Osama A Khamis, Amal El-Shehaby, Hussein Chahine, Ahmad Alaa Al-Din Ahmed, Mostafa A Alsawasany
Background: Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with end stage kidney disease who were maintained on regular hemodialysis. Methods: Sixty clinically stable chronic renal failure patients undergoing regular hemodialysis were enrolled in this cross sectional study...
June 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29597077/urine-cotinine-level-with-smoking-history-predicts-a-risk-of-coronary-artery-calcification
#7
Hui-Jin Yu, Sangeun Lim, Min-Kyeong Kim, Seungjun Lee, Min-Jung Kwon, Hyosoon Park, Hee-Yeon Woo
We investigated whether urine cotinine level, alone or combined with smoking status and cumulative smoking amount, could predict coronary calcium (CAC) score increase over time. The study population included 10,980 subjects. We analysed an association between CAC score increase over time and single or combined smoking-related factors. Urine cotinine level of ≥100 ng/mL, current or ex-smokers, and cumulative smoking amount of ≥1 pack-years (PY) showed significantly higher odds ratios (ORs) for CAC score increase over time...
March 21, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29590332/subclinical-coronary-artery-disease-in-swiss-hiv-positive-and-hiv-negative-persons
#8
Philip E Tarr, Bruno Ledergerber, Alexandra Calmy, Thanh Doco-Lecompte, Alex Marzel, Rainer Weber, Philipp A Kaufmann, René Nkoulou, Ronny R Buechel, Helen Kovari
Aims: HIV-positive persons have increased cardiovascular event rates but data on the prevalence of subclinical atherosclerosis compared with HIV-negative persons are not uniform. We assessed subclinical atherosclerosis utilizing coronary artery calcium (CAC) scoring and coronary computed tomography angiography (CCTA) in 428 HIV-positive participants of the Swiss HIV Cohort Study and 276 HIV-negative controls concurrently referred for clinically indicated CCTA. Methods and results: We assessed the association of HIV infection, cardiovascular risk profile, and HIV-related factors with subclinical atherosclerosis in univariable and multivariable analyses...
March 24, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29589390/high-brachial-ankle-pulse-wave-velocity-as-a-marker-for-predicting-coronary-artery-stenosis-in-patients-with-type-2-diabetes
#9
Bo Hyun Kim, Jae Sik Jang, Yong Seop Kwon, June Hyung Kim, In Joo Kim, Chang Won Lee
BACKGROUND: We evaluated the ability of brachial ankle pulse wave velocity (baPWV) to predict coronary artery stenosis (CAS) in patients with type 2 diabetes, and compared the predictive power of baPWV to that of well-known cardiovascular disease (CVD) risk calculators. METHODS: The study group included 83 consecutive patients over 30 years old with type 2 diabetes who complained of vague chest discomfort. An automatic pulse waveform analyzer was used to measure baPWV...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29579601/circulating-interleukin-6-is-a-biomarker-for-coronary-atherosclerosis-in-nonalcoholic-fatty-liver-disease-results-from-the-multi-ethnic-study-of-atherosclerosis
#10
Tracey G Simon, Maria Esther Perez Trejo, Robyn McClelland, Ryan Bradley, Michael J Blaha, Irfan Zeb, Kathleen E Corey, Matthew J Budoff, Raymond T Chung
BACKGROUND: Biomarkers to predict the presence and severity of subclinical cardiovascular disease (CVD) in nonalcoholic fatty liver disease (NAFLD) are lacking. METHODS: 3876 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), without known chronic liver disease underwent baseline non-contrast cardiac CT, with NAFLD defined by validated liver:spleen ratio (L:S) < 1.0, and subclinical CVD defined by coronary artery calcium (CAC) score > 0...
May 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29574458/coffee-consumption-and-coronary-artery-calcium-score-cross-sectional-results-of-elsa-brasil-brazilian-longitudinal-study-of-adult-health
#11
Andreia M Miranda, Josiane Steluti, Alessandra C Goulart, Isabela M Benseñor, Paulo A Lotufo, Dirce M Marchioni
BACKGROUND: Available evidence for the relationship between coffee intake and subclinical atherosclerosis is limited and inconsistent. This study aimed to evaluate the association between coffee consumption and coronary artery calcium (CAC) in ELSA-Brasil (Brazilian Longitudinal Study of Adult Health). METHODS AND RESULTS: This cross-sectional study is based on baseline data from participants of the ELSA-Brasil cohort. Only participants living in São Paulo, Brazil, who underwent a CAC measurement (n=4426) were included...
March 24, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29572286/add-on-antihypertensive-medications-to-angiotensin-aldosterone-system-blockers-in-diabetes-a-comparative-effectiveness-study
#12
Emily B Schroeder, Michel Chonchol, Susan M Shetterly, J David Powers, John L Adams, Julie A Schmittdiel, Gregory A Nichols, Patrick J O'Connor, John F Steiner
BACKGROUND AND OBJECTIVES: In individuals with diabetes, the comparative effectiveness of add-on antihypertensive medications added to an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker on the risk of significant kidney events is unknown. DESIGN, SETTING PARTICIPANTS, & MEASUREMENTS: We used an observational, multicenter cohort of 21,897 individuals with diabetes to compare individuals who added β -blockers, dihydropyridine calcium channel blockers, loop diuretics, or thiazide diuretics to angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers...
March 23, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29571781/influence-of-image-reconstruction-parameters-on-cardiovascular-risk-reclassification-by-computed-tomography-coronary-artery-calcium-score
#13
Cesare Mantini, Erica Maffei, Patrizia Toia, Fabrizio Ricci, Sara Seitun, Alberto Clemente, Roberto Malagò, Giuseppe Runza, Ludovico La Grutta, Massimo Midiri, Antonio Raffaele Cotroneo, Ernesto Forte, Filippo Cademartiri
OBJECTIVE: To investigate the influence of different CT reconstruction parameters on coronary artery calcium scoring (CACS) values and reclassification of predicted cardiovascular (CV) risk. METHODS: CACS was evaluated in 113 patients undergoing ECG-gated 64-slice CT. Reference CACS protocol included standard kernel filter (B35f) with slice thickness/increment of 3/1.5 mm, and field-of-view (FOV) of 150-180 mm. Influence of different image reconstruction algorithms (reconstructed slice thickness/increment 2...
April 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29564352/management-of-sequelae-of-kawasaki-disease-in-adults
#14
REVIEW
John B Gordon, Jane C Burns
Background: A growing population of young adults is presenting to cardiologists with late manifestations of Kawasaki disease (KD) that include cardiomyopathy, ischemia, and infarction. The management of these conditions differs in important ways from atherosclerotic heart disease, and yet there is little awareness in the adult cardiology community regarding the special challenges posed by the cardiovascular sequelae of KD. Methods: Observations were made on a population of 140 adult KD patients enrolled in the San Diego Adult KD Collaborative Study...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29562761/the-value-of-big-endothelin-1-in-the-assessment-of-the-severity-of-coronary-artery-calcification
#15
Fang Wang, Tiewei Li, Xiangfeng Cong, Zhihui Hou, Bin Lu, Zhou Zhou, Xi Chen
Progression of coronary artery calcification (CAC) was significantly associated with all-cause mortality, and high coronary artery calcium score (CACS) portends a particularly high risk of cardiovascular events. But how often one should rescan is still an unanswered question. Preliminary screening by testing circulating biomarker may be an alternative before repeat computed tomography (CT) scan. The aim of this study was to investigate the value of big endothelin-1 (bigET-1), the precursor of endothelin-1 (ET-1), in predicting the severity of CAC...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29556943/imaging-the-myocardial-ischemic-cascade
#16
REVIEW
Arthur E Stillman, Matthijs Oudkerk, David A Bluemke, Menko Jan de Boer, Jens Bremerich, Ernest V Garcia, Matthias Gutbertlet, Pim van der Harst, W Gregory Hundley, Michael Jerosch-Herold, Dirkjan Kuijpers, Raymond Y Kwong, Eike Nagel, Stamatios Lerakis, John Oshinski, Jean-François Paul, Riemer H J A Slart, Vinod Thourani, Rozemarijn Vliegenthart, Bernd J Wintersperger
Non-invasive imaging plays a growing role in the diagnosis and management of ischemic heart disease from its earliest manifestations of endothelial dysfunction to myocardial infarction along the myocardial ischemic cascade. Experts representing the North American Society for Cardiovascular Imaging and the European Society of Cardiac Radiology have worked together to organize the role of non-invasive imaging along the framework of the ischemic cascade. The current status of non-invasive imaging for ischemic heart disease is reviewed along with the role of imaging for guiding surgical planning...
March 19, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29556802/assessing-cardiovascular-disease-risk-and-responses-to-preventive-therapies-in-clinical-practice
#17
REVIEW
Kevin C Maki, Mary R Dicklin
PURPOSE OF REVIEW: The aims of this review are to provide perspective on evaluation of relative and absolute cardiovascular disease (CVD) risk reductions for assessing the efficacy of preventive therapies and to summarize methods for evaluation of CVD risk in clinical practice. RECENT FINDINGS: Major CVD risk factors can be used to stratify patients into risk categories. Results from recent trials reinforce the view that benefits of preventive therapies will be greatest in those with the highest absolute risk and in those with the most severe disturbance in the risk factor targeted...
March 20, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29554376/high-sensitivity-cardiac-troponin-i-is-a-biomarker-for-occult-coronary-plaque-burden-and-cardiovascular-events-in-patients-with-rheumatoid-arthritis
#18
George A Karpouzas, Joel Estis, Panteha Rezaeian, John Todd, Matthew J Budoff
Objectives: Patients with RA display greater occult coronary atherosclerosis burden and experience higher cardiovascular morbidity and mortality compared with controls. We here explored whether pro-inflammatory cytokines and high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, correlated with plaque burden and cardiovascular events (CVEs) in RA. Methods: We evaluated 150 patients with 64-slice coronary CT angiography. Coronary artery calcium, number of segments with plaque (segment involvement score), stenotic severity and plaque burden were assessed...
March 14, 2018: Rheumatology
https://www.readbyqxmd.com/read/29551663/high-pitch-versus-sequential-mode-for-coronary-calcium-in-individuals-with-a-high-heart-rate-potential-for-dose-reduction
#19
Marleen Vonder, Rozemarijn Vliegenthart, Merel A Kaatee, Carlijn M van der Aalst, Peter M A van Ooijen, Geertruida H de Bock, Jan Willem Gratama, Dirkjan Kuijpers, Harry J de Koning, Matthijs Oudkerk
BACKGROUND: To determine the impact of high-pitch spiral acquisition on radiation dose and cardiovascular disease (CVD) risk stratification by coronary artery calcium (CAC) assessment with computed tomography in individuals with a high heart rate. METHODS: Of the ROBINSCA trial, 1990 participants with regular rhythm and heart rates >65 beats per minute (bpm) were included. As reference, 390 participants with regular heart rates ≤65 bpm were used. All participants underwent prospectively electrocardiographically(ECG)-triggered imaging of the coronary arteries using dual source CT at 120 kVp, 80 ref mAs using both high-pitch spiral mode and sequential mode...
March 1, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29550494/elevated-lipoprotein-a-levels-are-associated-with-coronary-artery-calcium-scores-in-asymptomatic-individuals-with-a-family-history-of-premature-atherosclerotic-cardiovascular-disease
#20
Simone L Verweij, Maurice W J de Ronde, Rutger Verbeek, S Matthijs Boekholdt, R Nils Planken, Erik S G Stroes, Sara-Joan Pinto-Sietsma
BACKGROUND: Elevated lipoprotein(a) (Lp(a)) levels are associated with increased risk for atherosclerotic cardiovascular disease (ASCVD). Individuals with a family history of premature ASCVD are at increased cardiovascular risk with concomitantly a higher burden of (subclinical) atherosclerosis. However, whether Lp(a) contributes to the increased atherosclerotic burden in these individuals remains to be established. OBJECTIVE: In this study, we evaluated the association between Lp(a) levels and coronary atherosclerotic burden, assessed by coronary arterty calcium (CAC) scores, in asymptomatic individuals with a family history of premature ASCVD...
February 16, 2018: Journal of Clinical Lipidology
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