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https://www.readbyqxmd.com/read/28931399/principles-practices-and-knowledge-of-clinicians-when-assessing-febrile-children-a-qualitative-study-in-kenya
#1
Anneka M Hooft, Kelsey Ripp, Bryson Ndenga, Francis Mutuku, David Vu, Kimberly Baltzell, Linnet N Masese, John Vulule, Dunstan Mukoko, A Desiree LaBeaud
BACKGROUND: Clinicians in low resource settings in malaria endemic regions face many challenges in diagnosing and treating febrile illnesses in children. Given the change in WHO guidelines in 2010 that recommend malaria testing prior to treatment, clinicians are now required to expand the differential when malaria testing is negative. Prior studies have indicated that resource availability, need for additional training in differentiating non-malarial illnesses, and lack of understanding within the community of when to seek care play a role in effective diagnosis and treatment...
September 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28930265/a-review-on-ethno-medicinal-and-pharmacological-activities-of-sphenocentrum-jollyanum-pierre
#2
REVIEW
Olubukola Sinbad Olorunnisola, Olumide Samuel Fadahunsi, Peter Adegbola
Sphenocentrum jollyanum Pierre is a member of a diverse family of plants known as Menispermaceae. They are famous for a plethora of important biological functions. S. jollyanum is a shrub native to the tropical forest zones of West Africa and thrives in deep shade. It is widely cultivated in Cameroun, Sierra Leone, Nigeria, Ghana, and Côte d'Ivoire. S. jollyanum is employed in folk medicine as a cure for wounds, fever, coughs, high blood pressure, breast tumor, constipation, and as an aphrodisiac. Phytochemical investigations revealed that the plant is a rich source of secondary metabolites such as annin, alkaloids, saponins, and flavonoids...
July 3, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28851358/treatment-seeking-patterns-for-malaria-in-pharmacies-in-five-sub-saharan-african-countries
#3
Joël Ladner, Ben Davis, Etienne Audureau, Joseph Saba
BACKGROUND: Artemisinin-based combination therapy (ACT) is recommended as the first-line anti-malarial treatment strategy in sub-Saharan African countries. WHO policy recommends parasitological confirmation by microscopy or rapid diagnostic test (RDT) in all cases of suspected malaria prior to treatment. Gaps remain in understanding the factors that influence patient treatment-seeking behaviour and anti-malarial drug purchase decisions in the private sector. The objective of this study was to identify patient treatment-seeking behaviour in Ghana, Kenya, Nigeria, Tanzania, and Uganda...
August 29, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28764792/deployment-and-use-of-mobile-phone-technology-for-real-time-reporting-of-fever-cases-and-malaria-treatment-failure-in-areas-of-declining-malaria-transmission-in-muheza-district-north-eastern-tanzania
#4
Filbert Francis, Deus S Ishengoma, Bruno P Mmbando, Acleus S M Rutta, Mwelecele N Malecela, Benjamin Mayala, Martha M Lemnge, Edwin Michael
BACKGROUND: Early detection of febrile illnesses at community level is essential for improved malaria case management and control. Currently, mobile phone-based technology has been commonly used to collect and transfer health information and services in different settings. This study assessed the applicability of mobile phone-based technology in real-time reporting of fever cases and management of malaria by village health workers (VHWs) in north-eastern Tanzania. METHODS: The community mobile phone-based disease surveillance and treatment for malaria (ComDSTM) platform, combined with mobile phones and web applications, was developed and implemented in three villages and one dispensary in Muheza district from November 2013 to October 2014...
August 1, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28728558/accuracy-of-a-plasmodium-falciparum-specific-histidine-rich-protein-2-rapid-diagnostic-test-in-the-context-of-the-presence-of-non-malaria-fevers-prior-anti-malarial-use-and-seasonal-malaria-transmission
#5
Francois Kiemde, Massa Dit Achille Bonko, Marc Christian Tahita, Palpouguini Lompo, Toussaint Rouamba, Halidou Tinto, Michael Boele van Hensbroek, Petra F Mens, Henk D F H Schallig
BACKGROUND: It remains challenging to distinguish malaria from other fever causing infections, as a positive rapid diagnostic test does not always signify a true active malaria infection. This study was designed to determine the influence of other causes of fever, prior anti-malarial treatment, and a possible seasonality of the performance of a PfHRP2 RDT for the diagnosis of malaria in children under-5 years of age living in a malaria endemic area. METHODS: A prospective etiology study was conducted in 2015 among febrile children under 5 years of age in Burkina Faso...
July 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28670638/a-comparison-of-rapid-diagnostic-testing-by-plasmodium-lactate-dehydrogenase-and-quantitative-buffy-coat-technique-in-malaria-diagnosis-in-children
#6
Ifeanyi Kanayo Ifeorah, Biobele J Brown, Olugbemiro O Sodeinde
BACKGROUND: The World Health Organization (WHO) considers early and rapid diagnosis as one of the strategies to control malaria. This study compared the performance of Quantitative Buffy Coat (QBC) test and the Plasmodium lactate dehydrogenase (pLDH) rapid diagnostic test (RDT) with microscopy as the gold standard. MATERIALS AND METHODS: The study involved children ages 0-5 years who presented with a history of fever at the University College Hospital, Ibadan, Nigeria...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28545583/private-sector-role-readiness-and-performance-for-malaria-case-management-in-uganda-2015
#7
Henry Kaula, Peter Buyungo, Jimmy Opigo
BACKGROUND: Several interventions have been put in place to promote access to quality malaria case management services in Uganda's private sector, where most people seek treatment. This paper describes evidence using a mixed-method approach to examine the role, readiness and performance of private providers at a national level in Uganda. These data will be useful to inform strategies and policies for improving malaria case management in the private sector. METHODS: The ACTwatch national anti-malarial outlet survey was conducted concurrently with a fever case management study...
May 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28526075/testing-times-trends-in-availability-price-and-market-share-of-malaria-diagnostics-in-the-public-and-private-healthcare-sector-across-eight-sub-saharan-african-countries-from-2009-to-2015
#8
Kara Hanson, Catherine Goodman
BACKGROUND: The World Health Organization guidelines have recommended that all cases of suspected malaria should receive a confirmatory test with microscopy or a malaria rapid diagnostic test (RDT), however evidence from sub-Saharan Africa (SSA) illustrates that only one-third of children under five with a recent fever received a test. The aim of this study was to evaluate availability, price and market share of microscopy and RDT from 2009/11 to 2014/15 in 8 SSA countries, to better understand barriers to improving access to malaria confirmatory testing in the public and private health sectors...
May 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28521900/diagnosis-of-malarial-infection-using-change-in-properties-of-optically-trapped-red-blood-cells
#9
Apurba Paul, Ponnan Padmapriya, Vasant Natarajan
BACKGROUND: In previous work studying the properties of red blood cells (RBCs) held in an optical tweezers trap, we observed an increase in the spectrum of Brownian fluctuations for RBCs from a Plasmodium falciparum culture-due to increased rigidity of the cells-compared to normal RBCs. We wanted to extend the study to patient samples, since the earlier work was done with cultures grown in the lab. METHODS: Individual RBCs were held in an optical-tweezers trap. Its position fluctuations were measured and the power spectrum determined...
April 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28500775/vaccines-against-malaria-still-a-long-way-to-go
#10
REVIEW
Kai Matuschewski
Several species of Plasmodium cause a broad spectrum of human disease that range from nausea and fever to severe anemia, cerebral malaria, and multiorgan failure. In malaria-endemic countries, continuous exposure to Plasmodium sporozoite inoculations and subsequent blood infections elicit only partial and short-lived immunity, which gradually develops over many years of parasite exposure and multiple clinical episodes. The ambitious goal of malaria vaccinology over the past 70 years has been to develop an immunization strategy that mounts protection superior to naturally acquired immunity...
August 2017: FEBS Journal
https://www.readbyqxmd.com/read/28407772/the-end-of-a-dogma-the-safety-of-doxycycline-use-in-young-children-for-malaria-treatment
#11
REVIEW
Tiphaine Gaillard, Sébastien Briolant, Marylin Madamet, Bruno Pradines
Anti-malarial drug resistance to chloroquine and sulfadoxine-pyrimethamine has spread from Southeast Asia to Africa. Furthermore, the recent emergence of resistance to artemisinin-based combination therapy (ACT) in Southeast Asia highlights the need to identify new anti-malarial drugs. Doxycycline is recommended for malaria chemoprophylaxis for travel in endemic areas, or in combination with the use of quinine for malaria treatment when ACT is unavailable or when the treatment of severe malaria with artesunate fails...
April 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28406330/precarity-and-preparedness-non-adherence-as-institutional-work-in-diagnosing-and-treating-malaria-in-uganda
#12
René Umlauf
Access to anti-malarial drugs is increasingly governed by novel regulation technologies like rapid diagnostic tests (RDTs). However, high rates of non-adherence particularly to negative RDT results have been reported, threatening the cost-effectiveness of the two interrelated goals of improving diagnosis and reducing the over-prescription of expensive anti-malarial drugs. Below I set out to reconstruct prior treatment forms like presumptive treatment of malaria by paying particular attention to their institutional groundings...
July 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28404504/burden-of-asymptomatic-malaria-among-a-tribal-population-in-a-forested-village-of-central-india-a%C3%A2-hidden-challenge-for-malaria-control-in-india
#13
M K Chourasia, K Raghavendra, R M Bhatt, D K Swain, N Valecha, I Kleinschmidt
OBJECTIVE: Chhattisgarh in India is a malaria-endemic state with seven southern districts that contributes approximately 50-60% of the reported malaria cases in the state every year. The problem is further complicated due to asymptomatic malaria cases which are largely responsible for persistent transmission. This study was undertaken in one of the forested villages of the Keshkal subdistrict in Kondagaon district to ascertain the proportion of the population harbouring subclinical malarial infections...
June 2017: Public Health
https://www.readbyqxmd.com/read/28372570/malaria-over-diagnosis-in-cameroon-diagnostic-accuracy-of-fluorescence-and-staining-technologies-fast-malaria-stain-and-led-microscopy-versus-giemsa-and-bright-field-microscopy-validated-by-polymerase-chain-reaction
#14
Sean M Parsel, Steven A Gustafson, Edward Friedlander, Alexander A Shnyra, Aderosoye J Adegbulu, Ying Liu, Nicole M Parrish, Syed A Jamal, Eve Lofthus, Leo Ayuk, Charles Awasom, Carolyn J Henry, Carole P McArthur
BACKGROUND: Malaria is a major world health issue and its continued burden is due, in part, to difficulties in the diagnosis of the illness. The World Health Organization recommends confirmatory testing using microscopy-based techniques or rapid diagnostic tests (RDT) for all cases of suspected malaria. In regions where Plasmodium species are indigenous, there are multiple etiologies of fever leading to misdiagnoses, especially in populations where HIV is prevalent and children. To determine the frequency of malaria infection in febrile patients over an 8-month period at the Regional Hospital in Bamenda, Cameroon, we evaluated the clinical efficacy of the Flourescence and Staining Technology (FAST) Malaria stain and ParaLens Advance(TM) microscopy system (FM) and compared it with conventional bright field microscopy and Giemsa stain (GS)...
April 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28320390/false-negative-malaria-rapid-diagnostic-tests-in-rwanda-impact-of-plasmodium-falciparum-isolates-lacking-hrp2-and-declining-malaria-transmission
#15
Christina T Kozycki, Noella Umulisa, Stephen Rulisa, Emil I Mwikarago, Jean Pierre Musabyimana, Jean Pierre Habimana, Corine Karema, Donald J Krogstad
BACKGROUND: Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative RDTs and there are concerns the sensitivity of HRP2-based RDTs may fall when the intensity of transmission decreases. METHODS: This observational study enrolled 9226 patients at three health centres in Rwanda from April 2014 to April 2015...
March 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28219910/severe-plasmodium-knowlesi-with-dengue-coinfection
#16
Mohd Jazman Che Rahim, Nurashikin Mohammad, Alwi Muhd Besari, Wan Syamimee Wan Ghazali
We report a case of severe Plasmodium knowlesi and dengue coinfection in a previously healthy 59-year-old Malay man who presented with worsening shortness of breath, high-grade fever with chills and rigors, dry cough, myalgia, arthralgia, chest discomfort and poor appetite of 1 week duration. There was a history mosquito fogging around his neighbourhood in his hometown. Further history revealed that he went to a forest in Jeli (northern part of Kelantan) 3 weeks prior to the event. Initially he was treated as severe dengue with plasma leakage complicated with type 1 respiratory failure as evidenced by positive serum NS1-antigen and thrombocytopenia...
February 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28193740/development-of-delayed-hemolytic-anemia-after-treatment-with-oral-artemether-lumefantrine-in-two-patients-with-severe-falciparum-malaria
#17
Yasuhiro Tsuchido, Fukumi Nakamura-Uchiyama, Kasumi Toyoda, Moritoshi Iwagami, Kentaro Tochitani, Koh Shinohara, Naokuni Hishiya, Taku Ogawa, Kenji Uno, Kei Kasahara, Yukiteru Ouji, Shigeyuki Kano, Keiichi Mikasa, Tsunehiro Shimizu, Masahide Yoshikawa, Haruhiko Maruyama
AbstractRecently, reports of delayed hemolytic anemia after treatment with artemisinin and its derivatives have emerged. Here we report two cases of delayed hemolytic anemia in a patient with severe falciparum malaria after treatment with oral artemether-lumefantrine (AL). The first patient, a 20-year-old Japanese male student, was diagnosed with falciparum malaria and was administered AL. As having a high parasitemia rate (20.6%) was the only severe malaria criterion met in this case and his general condition was stable, we continued with AL treatment...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28185296/a-report-of-cerebral-malaria-treated-with-automated-red-blood-cell-exchange
#18
Waseem Q Anani, Gerald P Smith, Mehraboon Irani, Kathleen E Puca
BACKGROUND: Adjunctive automated whole blood or red blood cell exchange (RBCEx) can rapidly decrease malarial hyperparasitemia. Several case reports and series suggest improvement in clinical symptomatology; however, recent Centers of Disease Control and Prevention (CDC) recommendations concluded that RBCEx has no efficacy as an adjunctive therapy. We present a case of mental status changes secondary to cerebral malaria treated with automated RBCEx resulting in rapid and dramatic neurologic improvement...
April 2017: Transfusion
https://www.readbyqxmd.com/read/28153468/anti-malarial-synergy-of-secondary-metabolites-from-morinda-lucida-benth
#19
Bertha Chithambo, Xavier Siwe Noundou, Rui W M Krause
ETHNOPHARMACOLOGICAL RELEVANCE: The roots, stem and leaves of Morinda lucida are used in some African countries as treatment against different types of fevers including yellow fever, malaria, trypanosomiasis and feverish conditions during child birth. AIM OF THE STUDY: To determine the in vitro cell toxicity and anti-malarial activity of the extracts of stem bark of M. lucida and to identify the secondary metabolites in the extract that may be responsible for this activity...
March 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28152649/anti-inflammatory-anti-cholinergic-and-cytotoxic-effects-of-sida-rhombifolia
#20
Siau Hui Mah, Soek Sin Teh, Gwendoline Cheng Lian Ee
CONTEXT: Sida (Malvaceae) has been used as a traditional remedy for the treatment of diarrhoea, malarial, gastrointestinal dysentery, fevers, asthma and inflammation. OBJECTIVES: This study evaluates the anti-inflammatory, cytotoxic and anti-cholinergic activities of Sida rhombifolia Linn. whole plant for the first time. MATERIALS AND METHODS: S. rhombifolia whole plant was extracted by n-hexane, ethyl acetate and methanol using Soxhlet apparatus...
December 2017: Pharmaceutical Biology
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