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Malarial fever

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https://www.readbyqxmd.com/read/27895939/malaria-moderate-to-severe-anaemia-and-malarial-anaemia-in-children-at-presentation-to-hospital-in-the-mount-cameroon-area-a-cross-sectional-study
#1
Irene Ule Ngole Sumbele, Sharon Odmia Sama, Helen Kuokuo Kimbi, Germain Sotoing Taiwe
Background. Malaria remains a major killer of children in Sub-Saharan Africa, while anaemia is a public health problem with significant morbidity and mortality. Examining the factors associated with moderate to severe anaemia (MdSA) and malarial anaemia as well as the haematological characteristics is essential. Methodology. Children (1-14 years) at presentation at the Regional Hospital Annex-Buea were examined clinically and blood samples were collected for malaria parasite detection and full blood count evaluation...
2016: Anemia
https://www.readbyqxmd.com/read/27842555/low-prevalence-of-laboratory-confirmed-malaria-in-clinically-diagnosed-adult-women-from-the-wakiso-district-of-uganda
#2
Sergey Yegorov, Ronald M Galiwango, Aloysious Ssemaganda, Moses Muwanga, Irene Wesonga, George Miiro, David A Drajole, Kevin C Kain, Noah Kiwanuka, Bernard S Bagaya, Rupert Kaul
BACKGROUND: The malaria burden in sub-Saharan Africa (SSA) has fallen substantially. Nevertheless, malaria remains a serious health concern, and Uganda ranks third in SSA in total malaria burden. Epidemiological studies of adult malaria in Uganda are scarce and little is known about rates of malaria in non-pregnant adult women. This pilot study assessed malaria prevalence among adult women from Wakiso district, historically a highly malaria endemic region. METHODS: Adult women using public health services were screened for malaria, HIV and pregnancy...
November 14, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27830190/phenotypic-screens-identify-parasite-genetic-factors-associated-with-malarial-fever-response-in-plasmodium-falciparum-piggybac-mutants
#3
Phaedra Thomas, Jennifer Sedillo, Jenna Oberstaller, Suzanne Li, Min Zhang, Naresh Singh, Chengqi C Q Wang, Kenneth Udenze, Rays H Y Jiang, John H Adams
Malaria remains one of the most devastating parasitic diseases worldwide, with 90% of the malaria deaths in Africa in 2013 attributable to Plasmodium falciparum. The clinical symptoms of malaria include cycles of fever, corresponding to parasite rupture from red blood cells every 48 h. Parasite pathways involved in the parasite's ability to survive the host fever response, and indeed, the functions of ~40% of P. falciparum genes as a whole, are still largely unknown. Here, we evaluated the potential of scalable forward-genetic screening methods to identify genes involved in the host fever response...
September 2016: MSphere
https://www.readbyqxmd.com/read/27825318/prevalence-of-malaria-typhoid-toxoplasmosis-and-rubella-among-febrile-children-in-cameroon
#4
Olivia A Achonduh-Atijegbe, Kenji O Mfuh, Aristid H E Mbange, Jean P Chedjou, Diane W Taylor, Vivek R Nerurkar, Wilfred F Mbacham, Rose Leke
BACKGROUND: The current roll-out of rapid diagnostic tests (RDTs) in many endemic countries has resulted in the reporting of fewer cases of malaria-attributed illnesses. However, lack of knowledge of the prevalence of other febrile illnesses and affordable diagnostic tests means that febrile patients are not managed optimally. This study assessed the prevalence of commonly treatable or preventable febrile illnesses in children between 6 months and 15 years using rapid diagnostic tests at the point-of-care...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27821127/treatment-seeking-behaviour-and-associated-costs-for-malaria-in-papua-indonesia
#5
Muhammad Karyana, Angela Devine, Enny Kenangalem, Lenny Burdarm, Jeanne Rini Poespoprodjo, Ram Vemuri, Nicholas M Anstey, Emiliana Tjitra, Ric N Price, Shunmay Yeung
BACKGROUND: Malaria remains a significant public health issue in Eastern Indonesia, where multidrug resistant Plasmodium falciparum and Plasmodium vivax are highly prevalent. The objective of this study was to describe treatment-seeking behaviour and household costs prior to a change to a unified treatment policy of dihydroartemisinin-piperaquine in Mimika district, Papua province in 2006. METHODS: In 2005 a randomized cross-sectional household survey was conducted to collect data on demographics, socio-economic status (SES), treatment-seeking, case management, and household costs...
November 8, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27814767/optimal-price-subsidies-for-appropriate-malaria-testing-and-treatment-behaviour
#6
Kristian Schultz Hansen, Tine Hjernø Lesner, Lars Peter Østerdal
BACKGROUND: Malaria continues to be a serious public health problem particularly in Africa. Many people infected with malaria do not access effective treatment due to high price. At the same time many individuals receiving malaria drugs do not suffer from malaria because of the common practice of presumptive diagnosis. A global subsidy on artemisinin-based combination therapy (ACT) has recently been suggested to increase access to the most effective malaria treatment. METHODS: Following the recommendation by World Health Organization that parasitological testing should be performed before treatment and ACT prescribed to confirmed cases only, it is investigated in this paper if a subsidy on malaria rapid diagnostic tests (RDTs) should be incorporated...
November 4, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27762108/clinical-and-laboratory-profile-of-hospitalized-malarial-patients-an-agra-based-study
#7
Rajesh Deshwal
OBJECTIVE: The clinical presentations and laboratory profile of malaria has been changing over the years. Therefore this study was undertaken to study the clinical profile and laboratory parameters of malarial patients. METHODS: This prospective observational study was undertaken in military hospital with high prevalence of malaria. A total of 320 patients were studied. All patients tested positive by peripheral blood smear or rapid diagnostic test were included...
August 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27737665/therapeutic-efficacy-of-artemether-lumefantrine-for-the-treatment-of-uncomplicated-plasmodium-falciparum-malaria-from-three-highly-malarious-states-in-india
#8
Praveen K Bharti, Man M Shukla, Pascal Ringwald, Sri Krishna, Pushpendra P Singh, Ajay Yadav, Sweta Mishra, Usha Gahlot, Jai P Malaiya, Amit Kumar, Shambhu Prasad, Pradeep Baghel, Mohan Singh, Jaiprakash Vadadi, Mrigendra P Singh, Maria Dorina G Bustos, Leonard I Ortega, Eva-Maria Christophel, Sher S Kashyotia, Gagan S Sonal, Neeru Singh
BACKGROUND: Anti-malarial drug resistance continues to be a leading threat to malaria control efforts and calls for continued monitoring of waning efficacy of artemisinin-based combination therapy (ACT). Artesunate + sulfadoxine/pyrimethamine (AS + SP) is used for the treatment of uncomplicated Plasmodium falciparum malaria in India. However, resistance against AS + SP is emerged in northeastern states. Therefore, artemether-lumefantrine (AL) is the recommended first line treatment for falciparum malaria in north eastern states...
October 13, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27737634/a-prospective-study-of-the-importance-of-enteric-fever-as-a-cause-of-non-malarial-febrile-illness-in-patients-admitted-to-chittagong-medical-college-hospital-bangladesh
#9
Rapeephan R Maude, Aniruddha Ghose, Rasheda Samad, Hanna K de Jong, Masako Fukushima, Lalith Wijedoru, Mahtab Uddin Hassan, Md Amir Hossain, Md Rezaul Karim, Abdullah Abu Sayeed, Stannie van den Ende, Sujat Pal, A S M Zahed, Wahid Rahman, Rifat Karnain, Rezina Islam, Dung Thi Ngoc Tran, Tuyen Thanh Ha, Anh Hong Pham, James I Campbell, H Rogier van Doorn, Richard J Maude, Tom van der Poll, W Joost Wiersinga, Nicholas P J Day, Stephen Baker, Arjen M Dondorp, Christopher M Parry, Md Abul Faiz
BACKGROUND: Fever is a common cause of hospital admission in Bangladesh but causative agents, other than malaria, are not routinely investigated. Enteric fever is thought to be common. METHODS: Adults and children admitted to Chittagong Medical College Hospital with a temperature of ≥38.0 °C were investigated using a blood smear for malaria, a blood culture, real-time PCR to detect Salmonella Typhi, S. Paratyphi A and other pathogens in blood and CSF and an NS1 antigen dengue ELISA...
October 13, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27693771/exploring-the-antimalarial-potential-of-whole-cymbopogon-citratus-plant-therapy
#10
Uchechukwu M Chukwuocha, Omar Fernández-Rivera, Martha Legorreta-Herrera
ETHNOPHARMACOLOGICAL RELEVANCE: Cymbopogon citratus (lemon grass) has been used in traditional medicine as an herbal infusion to treat fever and malaria. Generally, whole plant extracts possess higher biological activity than purified compounds. However, the antimalarial activity of the whole C. citratus plant has not been experimentally tested. AIM OF THE STUDY: To evaluate the antimalarial activity of an herbal infusion and the whole Cymbopogon citratus plant in two experimental models of malaria...
September 29, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27660149/filling-gaps-on-ivermectin-knowledge-effects-on-the-survival-and-reproduction-of-anopheles-aquasalis-a-latin-american-malaria-vector
#11
Vanderson S Sampaio, Tatiana P Beltrán, Kevin C Kobylinski, Gisely C Melo, José B P Lima, Sara G M Silva, Íria C Rodriguez, Henrique Silveira, Maria G V B Guerra, Quique Bassat, Paulo F P Pimenta, Marcus V G Lacerda, Wuelton M Monteiro
BACKGROUND: Strategies designed to advance towards malaria elimination rely on the detection and treatment of infections, rather than fever, and the interruption of malaria transmission between mosquitoes and humans. Mass drug administration with anti-malarials directed at eliminating parasites in blood, either to entire populations or targeting only those with malaria infections, are considered useful strategies to progress towards malaria elimination, but may be insufficient if applied on their own...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27642433/-asymptomatic-parasitemia-in-under-five-school-age-children-and-households-self-medication-lubumbashi-democratic-republic-of-congo
#12
Sompwe Eric Mukomena, Cilundika Mulenga Philipe, Mashinda Kulimba Désiré, Lutumba Tshindele Pascal, Mapatano Mala Ali, Luboya Numbi Oscar
INTRODUCTION: Long neglected, asymptomatic malaria is currently recognized as a potential threat and obstacle to malaria control. In DR Congo, the prevalence of this parasite is poorly documented. This study aims to determine the prevalence of asymptomatic parasitaemia in children less than 5 years of age as well as in those aged over five years for what concerns ongoing mass control interventions (LLINs). METHODS: This is a cross-sectional study conducted among school age children, children less than 5 years of age living in the household of Lubumbashi...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27604542/multi-method-assessment-of-patients-with-febrile-illness-reveals-over-diagnosis-of-malaria-in-rural-uganda
#13
Ria R Ghai, Mary I Thurber, Azza El Bakry, Colin A Chapman, Tony L Goldberg
BACKGROUND: Health clinics in rural Africa are typically resource-limited. As a result, many patients presenting with fever are treated with anti-malarial drugs based only on clinical presentation. This is a considerable issue in Uganda, where malaria is routinely over-diagnosed and over-treated, constituting a wastage of resources and an elevated risk of mortality in wrongly diagnosed patients. However, rapid diagnostic tests (RDTs) for malaria are increasingly being used in health facilities...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27579480/efficacy-of-chloroquine-for-the-treatment-of-vivax-malaria-in-northwest-ethiopia
#14
Habtamu Bedimo Beyene, Melkamu Bedimo Beyene, Yehenew Asmamaw Ebstie, Zelalem Desalegn
BACKGROUND: Resistance to anti-malarials is a major challenge for effective malaria control in sub-Saharan Africa. This triggered a need for routine monitoring of the efficacy of the antimalarial drugs every two years in all malaria endemic countries. Chloroquine remained the drug of choice for the treatment of vivax malaria in Ethiopia. Though, a strong scientific evidence of chloroquine resistance to P.vivax that could have brought change of treatment regimen is yet to be established in Ethiopia, continuous and regular monitoring of drug's efficacy is critical for establishing rational anti-malarial drug policies...
2016: PloS One
https://www.readbyqxmd.com/read/27560094/lack-of-household-clustering-of-malaria-in-a-complex-humanitarian-emergency-implications-for-active-case-detection
#15
Hasan Hamze, Rhianna Charchuk, Makelele Katsuva Jean Paul, Kasereka Masumbuko Claude, Mashukano Léon, Michael T Hawkes
BACKGROUND: Malaria contributes to elevated morbidity and mortality in populations displaced by conflict in tropical zones. In an attempt to reduce malaria transmission in an internally displaced persons (IDP) camp in eastern Democratic Republic of Congo (DRC), we tested a strategy of active case detection of household contacts of malaria cases. METHODS: Prospective community-based survey. RESULTS: From a convenience sample of 100 febrile patients under 5 years of age from the IDP camp presenting to a nearby clinic for management of a fever episode, 19 cases of uncomplicated malaria and 81 controls with non-malarial febrile illness (NFMI) were diagnosed...
September 2016: Pathogens and Global Health
https://www.readbyqxmd.com/read/27543112/assessment-of-submicroscopic-infections-and-gametocyte-carriage-of-plasmodium-falciparum-during-peak-malaria-transmission-season-in-a-community-based-cross-sectional-survey-in-western-kenya-2012
#16
Zhiyong Zhou, Rebecca M Mitchell, Simon Kariuki, Christopher Odero, Peter Otieno, Kephas Otieno, Philip Onyona, Vincent Were, Ryan E Wiegand, John E Gimnig, Edward D Walker, Meghna Desai, Ya Ping Shi
BACKGROUND: Although malaria control intervention has greatly decreased malaria morbidity and mortality in many African countries, further decline in parasite prevalence has stagnated in western Kenya. In order to assess if malaria transmission reservoir is associated with this stagnation, submicroscopic infection and gametocyte carriage was estimated. Risk factors and associations between malaria control interventions and gametocyte carriage were further investigated in this study. METHODS: A total of 996 dried blood spot samples were used from two strata, all smear-positives (516 samples) and randomly selected smear-negatives (480 samples), from a community cross-sectional survey conducted at peak transmission season in 2012 in Siaya County, western Kenya...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27517717/malaria-related-perceptions-care-seeking-after-onset-of-fever-and-anti-malarial-drug-use-in-malaria-endemic-settings-of-southwest-ethiopia
#17
Zewdie Birhanu, Lakew Abebe, Morankar Sudhakar, Gunawardena Dissanayake, Yemane Ye-Ebiyo Yihdego, Guda Alemayehu, Delenasaw Yewhalaw
BACKGROUND: Prompt care seeking and appropriate use of anti-malarial drugs are critical components of malaria prevention and control. This study assessed malaria related perceptions, care seeking behavior and anti-malarial drug use in malaria endemic settings of Ethiopia. METHODS: Data were generated from a community based cross-sectional study conducted among 798 households during January 2014 as part of a larger household behavioral study in three malaria endemic districts of Jimma Zone, Southwest Ethiopia...
2016: PloS One
https://www.readbyqxmd.com/read/27488343/integrated-paediatric-fever-management-and-antibiotic-over-treatment-in-malawi-health-facilities-data-mining-a-national-facility-census
#18
Emily White Johansson, Katarina Ekholm Selling, Humphreys Nsona, Bonnie Mappin, Peter W Gething, Max Petzold, Stefan Swartling Peterson, Helena Hildenwall
BACKGROUND: There are growing concerns about irrational antibiotic prescription practices in the era of test-based malaria case management. This study assessed integrated paediatric fever management using malaria rapid diagnostic tests (RDT) and Integrated Management of Childhood Illness (IMCI) guidelines, including the relationship between RDT-negative results and antibiotic over-treatment in Malawi health facilities in 2013-2014. METHODS: A Malawi national facility census included 1981 observed sick children aged 2-59 months with fever complaints...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27384596/therapeutic-efficacy-and-effects-of-artesunate-amodiaquine-and-artemether-lumefantrine-on-malaria-associated-anaemia-in-nigerian-children-aged-two-years-and-under
#19
Akintunde Sowunmi, Kazeem Akano, Adejumoke I Ayede, Godwin Ntadom, Elsie O Adewoye, Bayo Fatunmbi, Temitope Aderoyeje
BACKGROUND: Artemisinin-based combination therapies are recommended as first-line treatments for uncomplicated falciparum malaria, but there is little evaluation of their efficacy and effects on uncomplicated malaria-associated anaemia in children aged 2 years and under. METHODS: Parasitological efficacy and effects on malaria-associated anaemia were evaluated in 250 malarious children aged 2 years and under, and efficacy was evaluated in 603 malarious children older than two but younger than 5 years of age following treatment with artesunate-amodiaquine (AA) or artemether-lumefantrine (AL)...
July 6, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27353131/understanding-malarial-toxins
#20
REVIEW
Katarina Starkl Renar, Jernej Iskra, Igor Križaj
Recognized since antiquity, malaria is one of the most infamous and widespread infectious diseases in humans and, although the death rate during the last century has been diminishing, it still accounts for more than a half million deaths annually. It is caused by the Plasmodium parasite and typical symptoms include fever, shivering, headache, diaphoresis and nausea, all resulting from an excessive inflammatory response induced by malarial toxins released into the victim's bloodstream. These toxins are hemozoin and glycosylphosphatidylinositols...
September 1, 2016: Toxicon: Official Journal of the International Society on Toxinology
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