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Malaria fever

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https://www.readbyqxmd.com/read/27914754/antiparasitic-and-disease-modifying-activity-of-nyctanthes-arbor-tristis-linn-in-malaria-an-exploratory-clinical-study
#1
Chhaya S Godse, Prakash S Tathed, Sameer S Talwalkar, Rama A Vaidya, Ashok J Amonkar, Akhil B Vaidya, Ashok D B Vaidya
BACKGROUND: An unceasing threat of drug resistance continuously poses demand for new antimalarial drugs. A scientific assessment of traditionally used antimalarial plants through reverse pharmacology is crucial for a fast track drug discovery. An Ayurvedic plant Nyctanthesarbor-tristis Linn. - (Parijat) had shown antimalarial activity, with a parasite clearance in 76.6% of 120 patients, in an earlier clinical study. OBJECTIVE: To further explore antimalarial potential of the plant through additional objective markers...
November 30, 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27907013/development-and-implementation-of-the-ebola-traveler-monitoring-program-and-clinical-outcomes-of-monitored-travelers-during-october-may-2015-minnesota
#2
Aaron DeVries, Pamela Talley, Kristin Sweet, Susan Kline, Patricia Stinchfield, Pritish Tosh, Richard Danila
BACKGROUND: In October 2014, the United States began actively monitoring all persons who had traveled from Guinea, Liberia, and Sierra Leone in the previous 21 days. State public health departments were responsible for monitoring all travelers; Minnesota has the largest Liberian population in the United States. The MDH Ebola Clinical Team (ECT) was established to assess travelers with symptoms of concern for Ebola virus disease (EVD), coordinate access to healthcare at appropriate facilities including Ebola Assessment and Treatment Units (EATU), and provide guidance to clinicians...
2016: PloS One
https://www.readbyqxmd.com/read/27895939/malaria-moderate-to-severe-anaemia-and-malarial-anaemia-in-children-at-presentation-to-hospital-in-the-mount-cameroon-area-a-cross-sectional-study
#3
Irene Ule Ngole Sumbele, Sharon Odmia Sama, Helen Kuokuo Kimbi, Germain Sotoing Taiwe
Background. Malaria remains a major killer of children in Sub-Saharan Africa, while anaemia is a public health problem with significant morbidity and mortality. Examining the factors associated with moderate to severe anaemia (MdSA) and malarial anaemia as well as the haematological characteristics is essential. Methodology. Children (1-14 years) at presentation at the Regional Hospital Annex-Buea were examined clinically and blood samples were collected for malaria parasite detection and full blood count evaluation...
2016: Anemia
https://www.readbyqxmd.com/read/27881136/community-health-workers-adherence-to-referral-guidelines-evidence-from-studies-introducing-rdts-in-two-malaria-transmission-settings-in-uganda
#4
Sham Lal, Richard Ndyomugenyi, Lucy Paintain, Neal D Alexander, Kristian S Hansen, Pascal Magnussen, Daniel Chandramohan, Siân E Clarke
BACKGROUND: Many malaria-endemic countries have implemented national community health worker (CHW) programmes to serve remote populations that have poor access to malaria diagnosis and treatment. Despite mounting evidence of CHWs' ability to adhere to malaria rapid diagnostic tests (RDTs) and treatment guidelines, there is limited evidence whether CHWs adhere to the referral guidelines and refer severely ill children for further management. In southwest Uganda, this study examined whether CHWs referred children according to training guidelines and described factors associated with adherence to the referral guideline...
November 24, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27876974/mosquito-larvicidal-activity-of-cadmium-nanoparticles-synthesized-from-petal-extracts-of-marigold-tagetes-sp-and-rose-rosa-sp-flower
#5
Amita Hajra, Snehali Dutta, Naba Kumar Mondal
Mosquitoes are blood-thirsty insects and serve as the most important vectors for spreading most notorious diseases such as malaria, yellow fever, dengue fever, and filariasis. The extensive use of synthetic mosquito repellent has resulted in resistance in mosquitoes. Therefore, the development of a reliable, eco-friendly processes for the synthesis of nano dimensional materials is an utmost important aspect of nanotechnology. In the present study, authors report absolute green synthesis of cadmium nanoparticles using marigold and rose flower petal extract...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27866822/correlates-of-physical-activity-among-young-children-with-moderate-acute-malnutrition
#6
Charles W Yaméogo, Bernardette Cichon, Christian Fabiansen, Ann-Sophie Iuel-Brockdorf, Susan Shepherd, Suzanne Filteau, Alfred S Traoré, Vibeke B Christensen, Kim F Michaelsen, Soren Brage, Henrik Friis, Daniel Faurholt-Jepsen
OBJECTIVE: To assess the levels of physical activity among young children with moderate acute malnutrition and to identify clinical, biochemical, anthropometric, and sociodemographic correlates of physical activity. STUDY DESIGN: In a cross-sectional study, 1609 children aged 6-23 months wore a triaxial accelerometer (ActiGraph GT3x+; ActiGraph, Pensacola, Florida) for 6 consecutive days, from which total physical activity were determined. Data on morbidity were collected based by history and physical examination, and serum C-reactive protein and α1-acid glycoprotein were measured...
November 18, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27860197/crispr-cas9-the-ultimate-weapon-to-battle-infectious-diseases
#7
REVIEW
M Doerflinger, W Forsyth, G Ebert, M Pellegrini, M J Herold
Infectious diseases are a leading cause of death worldwide. Novel therapeutics are urgently required to treat multidrug-resistant organisms such as Mycobacterium tuberculosis and to mitigate morbidity and mortality caused by acute infections such as malaria and dengue fever virus as well as chronic infections such as human immunodeficiency virus-1 and hepatitis B virus. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system, which has revolutionized biomedical research, holds great promise for the identification and validation of novel drug targets...
November 16, 2016: Cellular Microbiology
https://www.readbyqxmd.com/read/27859692/louse-borne-relapsing-fever-in-finland-in-two-asylum-seekers-from-somalia
#8
Jukka Hytönen, Tamim Khawaja, Juha O Grönroos, Anna Jalava, Seppo Meri, Jarmo Oksi
We report two cases of louse-borne relapsing fever (LBRF) in young Somali asylum seekers having recently arrived to Finland. They had sought medical attention for a febrile illness. Blood smears were examined for suspected malaria, but instead, spirochete shaped bacteria were observed. The bacteria were confirmed as Borrelia recurrentis by PCR and sequencing. The patients survived, but their treatment was complicated by Jarisch-Herxheimer reaction. We conclude that LBRF must be considered as a diagnostic option in febrile refugees also in the northernmost parts of Europe...
November 16, 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27857610/predictors-of-specific-anti-brucella-antibodies-among-humans-in-agro-pastoral-communities-in-sengerema-district-mwanza-tanzania-the-need-for-public-awareness
#9
Elifuraha B Mngumi, Mariam M Mirambo, Sospeter Wilson, Stephen E Mshana
BACKGROUND: Human brucellosis remains to be a neglected zoonotic disease among agro-pastoral communities where livestock rearing is one of the main economic activities. This study was conducted in different agro-pastoral communities in Sengerema district, Mwanza, Tanzania, to determine seroprevalence and predictors of anti-Brucella antibodies, information that may influence public awareness on the risk factors and strategies to improve the diagnosis of brucellosis in developing countries...
2016: Tropical Medicine and Health
https://www.readbyqxmd.com/read/27855644/febrile-illness-diagnostics-and-the-malaria-industrial-complex-a-socio-environmental-perspective
#10
Justin Stoler, Gordon A Awandare
BACKGROUND: Global prioritization of single-disease eradication programs over improvements to basic diagnostic capacity in the Global South have left the world unprepared for epidemics of chikungunya, Ebola, Zika, and whatever lies on the horizon. The medical establishment is slowly realizing that in many parts of sub-Saharan Africa (SSA), particularly urban areas, up to a third of patients suffering from acute fever do not receive a correct diagnosis of their infection. MAIN BODY: Malaria is the most common diagnosis for febrile patients in low-resource health care settings, and malaria misdiagnosis has soared due to the institutionalization of malaria as the primary febrile illness of SSA by international development organizations and national malaria control programs...
November 17, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27852705/non-treatment-of-children-with-community-health-worker-diagnosed-fast-breathing-pneumonia-in-rural-malawi-exploratory-subanalysis-of-a-prospective-cohort-study
#11
Carina King, Tim Colbourn, Limangeni Mankhambo, James Beard, Debbie C Hay Burgess, Anthony Costello, Rasa Izadnegahdar, Norman Lufesi, Charles Mwansambo, Bejoy Nambiar, Eric S Johnson, Robert W Platt, David Mukanga, Eric D McCollum
BACKGROUND: Despite recent progress, pneumonia remains the largest infectious killer of children globally. This paper describes outcomes of not treating community-diagnosed fast-breathing pneumonia on patient recovery. METHODS: We conducted an exploratory subanalysis of an observational prospective cohort study in Malawi. We recruited children (2-59 months) diagnosed by community health workers with fast-breathing pneumonia using WHO integrated community case management (iCCM) guidelines...
November 16, 2016: BMJ Open
https://www.readbyqxmd.com/read/27848905/-splenomegaly-in-an-eritrean-refugee-the-hyper-reactive-malaria-splenomegaly-syndrome
#12
M M Cruijsen, I J Reuling, M Keuter, R W Sauerwein, A J van der Ven, Q de Mast
BACKGROUND: Hyper-reactive malaria splenomegaly (HMS) is a rare and potentially severe complication of malaria. It is likely that the incidence of patients with HMS will rise in the Netherlands due to the recent increase in asylum-seekers from Sub-Saharan Africa. It can be difficult to diagnose this disease, as this case shows. CASE DESCRIPTION: A 31-year-old male from Eritrea was admitted with fever and dyspnea, caused by an influenza A-infection. The patient also presented with cachexia, pronounced hepatosplenomegaly and pancytopenia...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27847373/a-multicenter-pivotal-clinical-trial-of-a-urine-malaria-test-umt-for-the-rapid-diagnosis-of-plasmodium-falciparum-malaria
#13
Wellington A Oyibo, Nnenna Ezeigwe, Godwin Ntadom, Oladipo O Oladosu, Kaitlin Rainwater, Wendy O'Meara, Evaezi Okpokoro, William Brieger
BACKGROUND: The need to expand malaria diagnosis alongside policy requirements for mandatory testing before treatment motivates exploration of non-invasive rapid diagnostic tests (RDTs). We report the outcome of the first cross-sectional, single-blind clinical performance evaluation of a Urine Malaria Test (UMT) for Plasmodium falciparum (Pf) malaria diagnosis in febrile patients. METHODS: Matched urine and fingerprick blood from participants ≥2 years with fever (axillary temperature ≥37...
November 9, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27843830/international-classification-of-primary-care-2-coding-of-primary-care-data-at-the-general-out-patients-clinic-of-general-hospital-lagos-nigeria
#14
Olawunmi Abimbola Olagundoye, Kees van Boven, Chris van Weel
BACKGROUND: Primary care serves as an integral part of the health systems of nations especially the African continent. It is the portal of entry for nearly all patients into the health care system. Paucity of accurate data for health statistics remains a challenge in the most parts of Africa because of inadequate technical manpower and infrastructure. Inadequate quality of data systems contributes to inaccurate data. A simple-to-use classification system such as the International Classification of Primary Care (ICPC) may be a solution to this problem at the primary care level...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27842555/low-prevalence-of-laboratory-confirmed-malaria-in-clinically-diagnosed-adult-women-from-the-wakiso-district-of-uganda
#15
Sergey Yegorov, Ronald M Galiwango, Aloysious Ssemaganda, Moses Muwanga, Irene Wesonga, George Miiro, David A Drajole, Kevin C Kain, Noah Kiwanuka, Bernard S Bagaya, Rupert Kaul
BACKGROUND: The malaria burden in sub-Saharan Africa (SSA) has fallen substantially. Nevertheless, malaria remains a serious health concern, and Uganda ranks third in SSA in total malaria burden. Epidemiological studies of adult malaria in Uganda are scarce and little is known about rates of malaria in non-pregnant adult women. This pilot study assessed malaria prevalence among adult women from Wakiso district, historically a highly malaria endemic region. METHODS: Adult women using public health services were screened for malaria, HIV and pregnancy...
November 14, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27842542/asymptomatic-only-at-first-sight-malaria-infection-among-schoolchildren-in-highland-rwanda
#16
Kevin C Sifft, Dominik Geus, Caritas Mukampunga, Jean Claude Mugisha, Felix Habarugira, Kira Fraundorfer, Claude Bayingana, Jules Ndoli, Irenee Umulisa, Corine Karema, George von Samson-Himmelstjerna, Toni Aebischer, Peter Martus, Augustin Sendegeya, Jean Bosco Gahutu, Frank P Mockenhaupt
BACKGROUND: Plasmodium infection and malaria in school children are increasingly recognized as a relevant public health problem, but data on actual prevalence and health consequences are insufficient. The present study from highland southern Rwanda aimed at estimating infection prevalence among children attending school, at identifying associated factors and at assessing the clinical consequences of these infections. METHODS: In a survey including 12 schools in the Huye district of Rwanda, 1089 children aged 6-10 years were clinically and anthropometrically examined, malaria parasites were diagnosed by microscopy and PCR, haemoglobin concentrations were measured, and socio-economic and behavioural parameters as well as medical histories were obtained...
November 14, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27830190/phenotypic-screens-identify-parasite-genetic-factors-associated-with-malarial-fever-response-in-plasmodium-falciparum-piggybac-mutants
#17
Phaedra Thomas, Jennifer Sedillo, Jenna Oberstaller, Suzanne Li, Min Zhang, Naresh Singh, Chengqi C Q Wang, Kenneth Udenze, Rays H Y Jiang, John H Adams
Malaria remains one of the most devastating parasitic diseases worldwide, with 90% of the malaria deaths in Africa in 2013 attributable to Plasmodium falciparum. The clinical symptoms of malaria include cycles of fever, corresponding to parasite rupture from red blood cells every 48 h. Parasite pathways involved in the parasite's ability to survive the host fever response, and indeed, the functions of ~40% of P. falciparum genes as a whole, are still largely unknown. Here, we evaluated the potential of scalable forward-genetic screening methods to identify genes involved in the host fever response...
September 2016: MSphere
https://www.readbyqxmd.com/read/27826886/rarity-of-mixed-species-malaria-with-plasmodium-falciparum-and-plasmodium-malariae-in-travelers-to-saarland-in-germany
#18
Josef Yayan, Kurt Rasche
Malaria is an acute, life-threatening infectious disease that spreads in tropical and subtropical regions. Malaria is mainly brought over to Germany by travelers, so the disease can be overlooked due to its nonspecific symptoms and a lack of experience of attending physicians. The aim of this study was to analyze, retrospectively, epidemiological and clinical data from patients examined for malaria. Patient data were collected from hospital charts at the Department of Internal Medicine, Saarland University Medical Center, Germany, for the period of 2004-2012...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27825738/the-gametocytocidal-efficacy-of-different-single-doses-of-primaquine-with-dihydroartemisinin-piperaquine-in-asymptomatic-parasite-carriers-in-the-gambia-a-randomized-controlled-trial
#19
Joseph Okebe, Teun Bousema, Muna Affara, Gian Luca Di Tanna, Edgard Dabira, Abdoulaye Gaye, Frank Sanya-Isijola, Henry Badji, Simon Correa, Davis Nwakanma, Jean-Pierre Van Geertruyden, Chris Drakeley, Umberto D'Alessandro
BACKGROUND: Asymptomatic low-density gametocyte carriers represent the majority of malaria-infected individuals. However, the impact of recommended treatment with single low dose of primaquine and an artemisinin-based combination therapy to reduce transmission in this group is unknown. METHODS: This was a four-arm, open label, randomized controlled trial comparing the effect of dihydroartemisinin-piperaquine (DHAP) alone or combined with single dose of primaquine (PQ) at 0...
October 23, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27825318/prevalence-of-malaria-typhoid-toxoplasmosis-and-rubella-among-febrile-children-in-cameroon
#20
Olivia A Achonduh-Atijegbe, Kenji O Mfuh, Aristid H E Mbange, Jean P Chedjou, Diane W Taylor, Vivek R Nerurkar, Wilfred F Mbacham, Rose Leke
BACKGROUND: The current roll-out of rapid diagnostic tests (RDTs) in many endemic countries has resulted in the reporting of fewer cases of malaria-attributed illnesses. However, lack of knowledge of the prevalence of other febrile illnesses and affordable diagnostic tests means that febrile patients are not managed optimally. This study assessed the prevalence of commonly treatable or preventable febrile illnesses in children between 6 months and 15 years using rapid diagnostic tests at the point-of-care...
November 8, 2016: BMC Infectious Diseases
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