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https://www.readbyqxmd.com/read/29784001/appropriateness-of-malaria-diagnosis-and-treatment-for-fever-episodes-according-to-patient-history-and-anti-malarial-blood-measurement-a-cross-sectional-survey-from-tanzania
#1
Joanna Gallay, Dominic Mosha, Erick Lutahakana, Festo Mazuguni, Martin Zuakulu, Laurent Arthur Decosterd, Blaise Genton, Emilie Pothin
BACKGROUND: Monitoring the impact of case management strategies at large scale is essential to evaluate the public health benefit they confer. The use of methodologies relying on objective and standardized endpoints, such as drug levels in the blood, should be encouraged. Population drug use, diagnosis and treatment appropriateness in case of fever according to patient history and anti-malarials blood concentration was evaluated. METHODS: A cross-sectional survey took place between May and August 2015 in three regions of Tanzania with different levels of malaria endemicity...
May 21, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29780012/epidemiological-clinical-and-laboratory-evaluation-of-plasmodium-falciparum-malaria-cases-followed-in-firat-university-hospital-a-6-year-retrospective-analysis
#2
Ayşe Sağmak Tartar, Ayhan Akbulut
OBJECTIVE: Malaria is an infectious disease caused by Plasmodium parasite. Sporadic cases have not been observed in Turkey since 2010, but imported malaria cases are still prevalent owing to migration. The present study aimed to evaluate Plasmodium falciparum malaria in patients hospitalized in our hospital. METHODS: A total of 15 adult patients (14 males and 1 female) who were diagnosed with malaria and who were managed at our clinic between January 2011 and 2017 were evaluated retrospectively for their epidemiological, clinical, and laboratory findings; treatment; and prognosis...
March 2018: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#3
REVIEW
José Moreira, Clarisse S Bressan, Patricia Brasil, Andre M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America (LA) are diverse and its complexity increase as the proportion of fever due to malaria decreases as control and new pathogens emerge in the region. In this context, it is important to shed light over the gaps on the epidemiological characteristics and the geographic range for many AFI aetiologies. AIMS: To review studies on community-acquired fever etiology other than malaria in LA, and to highlight knowledge gaps and challenges needing further investigation...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29774286/biological-control-of-anopheles-darlingi-aedes-aegypti-and-culex-quinquefasciatus-larvae-using-shrimps
#4
Willian Marinho Dourado Coelho, Juliana de Carvalho Apolinário Coêlho, Katia Denise Saraiva Bresciani, Wilma Aparecida Starke Buzetti
Mosquitoes can act as vectors of important diseases such as malaria, dengue, Zika virus, yellow fever, Chikungunya and Mayaro fever, in addition to filariasis. The use of insecticides, larvicides, bed nets and repellents, besides the use of drugs as chemoprevention and the treatment of the sick are currently the pillars of the control of these vectors. We studied the biological control against of Anopheles darlingi , Aedes aegypti and Culex quinquefasciatus larvae using shrimps of the species M. pantanalense , M...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29769128/the-impact-of-the-scale-up-of-malaria-rapid-diagnostic-tests-on-the-routine-clinical-diagnosis-procedures-for-febrile-illness-a-series-of-repeated-cross-sectional-studies-in-papua-new-guinea
#5
Justin Pulford, Serah Kurumop, Ivo Mueller, Peter M Siba, Manuel W Hetzel
BACKGROUND: This paper examines the impact of the scale-up of malaria rapid diagnostic tests (RDT) on routine clinical diagnosis procedures for febrile illness in primary healthcare settings in Papua New Guinea. METHODS: Repeat, cross-sectional surveys in randomly selected primary healthcare services were conducted. Surveys included passive observation of consecutive febrile case management cases and were completed immediately prior to RDT scale-up (2011) and at 12- (2012) and 60-months (2016) post scale-up...
May 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29769064/antimicrobial-and-antioxidant-activities-of-triterpenoid-and-phenolic-derivatives-from-two-cameroonian-melastomataceae-plants-dissotis-senegambiensis-and-amphiblemma-monticola
#6
Raissa Tioyem Nzogong, Fabrice Sterling Tchantchou Ndjateu, Steve Endeguele Ekom, Jules-Arnaud Mboutchom Fosso, Maurice Ducret Awouafack, Mathieu Tene, Pierre Tane, Hiroyuki Morita, Muhammad Iqbal Choudhary, Jean-de-Dieu Tamokou
BACKGROUND: Antimicrobial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antimicrobial and antioxidant activities of ethanol extracts and compounds isolated from Dissotis senegambiensis and Amphiblemma monticola, two Cameroonian Melastomataceae species traditionally used for the treatment of fever, malaria and infectious diseases. METHODS: The plant extracts were prepared by maceration in ethanol...
May 16, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29740973/findings-from-a-cluster-randomised-trial-of-unconditional-cash-transfers-in-niger
#7
Victoria L Sibson, Carlos S Grijalva-Eternod, Garba Noura, Julia Lewis, Kwanli Kladstrup, Hassan Haghparast-Bidgoli, Jolene Skordis-Worrall, Tim Colbourn, Joanna Morrison, Andrew J Seal
Unconditional cash transfers (UCTs) are used as a humanitarian intervention to prevent acute malnutrition, despite a lack of evidence about their effectiveness. In Niger, UCT and supplementary feeding are given during the June-September "lean season," although admissions of malnourished children to feeding programmes may rise from March/April. We hypothesised that earlier initiation of the UCT would reduce the prevalence of global acute malnutrition (GAM) in children 6-59 months old in beneficiary households and at population level...
May 8, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29737455/current-and-future-use-of-chloroquine-and-hydroxychloroquine-in-infectious-immune-neoplastic-and-neurological-diseases-a-mini-review
#8
REVIEW
Domenico Plantone, Tatiana Koudriavtseva
The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), rheumatological (systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, Sjögren's syndrome), and other immunological diseases. Indeed, they have anti-inflammatory, immunomodulating, anti-infective, antithrombotic, and metabolic effects...
May 8, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29734716/nutraceutical-and-ethnopharmacological-properties-of-vangueria-infausta-subsp-infausta
#9
REVIEW
Alfred Maroyi
Vangueria infausta subsp. infausta (VI) is a nutraceutical with plant parts valued in several cultures for its medicinal properties. Traditionally, VI is used against gastro-intestinal disorders, malaria, pneumonia, cough, menstrual problems, parasitic worms, chest complaints, snake bites, infertility, fever, candidiasis and abdominal pains. This study aims to critically summarize the nutraceutical properties, phytochemistry and pharmacology of VI with a view to provide baseline data required for further investigations on this plant...
May 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29734660/syzygium-cordatum-hochst-ex-krauss-an-overview-of-its-ethnobotany-phytochemistry-and-pharmacological-properties
#10
REVIEW
Alfred Maroyi
Syzygium cordatum is a valuable medicinal plant in the materia medica of east and southern Africa. The aim of this study was to review the botany, medicinal uses, phytochemistry and ethnopharmacological properties of S. cordatum . Relevant literature search was carried out using internet sources such as ACS, Web of Science, Wiley, SpringerLink, Scopus, Mendeley, Google Scholar, Pubmed, SciFinder, BioMed Central, Science Direct and Elsevier. Other literature sources were conference papers, book chapters, books, theses and websites...
May 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29720163/caregivers-compliance-with-referral-advice-evidence-from-two-studies-introducing-mrdts-into-community-case-management-of-malaria-in-uganda
#11
Sham Lal, Richard Ndyomugenyi, Lucy Paintain, Neal D Alexander, Kristian S Hansen, Pascal Magnussen, Daniel Chandramohan, Siân E Clarke
BACKGROUND: Several malaria endemic countries have implemented community health worker (CHW) programmes to increase access to populations underserved by health care. There is considerable evidence on CHW adherence to case management guidelines, however, there is limited evidence on the compliance to referral advice and the outcomes of children under-5 referred by CHWs. This analysis examined whether caregivers complied with CHWs referral advice. METHODS: Data from two cluster (village) randomised trials, one in a moderate-to-high malaria transmission setting, another in a low-transmission setting conducted between January 2010-July 2011 were analysed...
May 2, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29718912/microrna-profiles-and-functions-in-mosquitoes
#12
Xinyu Feng, Shuisen Zhou, Jingwen Wang, Wei Hu
Mosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization and function of individual miRNAs and their potential targets have not been fully determined to date. We conducted a systematic review of published literature following PRISMA guidelines. We summarize the information about miRNAs in mosquitoes to better understand their metabolism, development, and responses to microorganisms...
May 2, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29706314/dengue-haemorrhagic-fever-an-emerging-disease-in-nigeria-west-africa
#13
REVIEW
Ademola Hezekiah Fagbami, Anyebe Bernard Onoja
INTRODUCTION: In Nigeria, dengue fever caused by dengue virus, types 1 and 2 has been diagnosed for many years. Although, seroepidemiological surveys have shown that dengue virus activity is, widespread in the country, there is scanty information on dengue, hemorrhagic fever with little attention paid to dengue fever largely, because it presents as classical dengue fever characterized by fever, myalgia, headache, arthralgia, retro-orbital pain, gastro intestinal, symptoms and skin rash...
April 26, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29703200/characterization-of-plasmodium-falciparum-and-plasmodium-vivax-recent-exposure-in-an-area-of-significantly-decreased-transmission-intensity-in-central-vietnam
#14
Johanna Helena Kattenberg, Annette Erhart, Minh Hieu Truong, Eduard Rovira-Vallbona, Khac Anh Dung Vu, Thi Hong Ngoc Nguyen, Van Hong Nguyen, Van Van Nguyen, Melanie Bannister-Tyrrell, Michael Theisen, Adam Bennet, Andrew A Lover, Thanh Duong Tran, Xuan Xa Nguyen, Anna Rosanas-Urgell
BACKGROUND: In Vietnam, malaria transmission has been reduced to very low levels over the past 20 years, and as a consequence, the country aims to eliminate malaria by 2030. This study aimed to characterize the dynamics and extent of the parasite reservoir in Central Vietnam, in order to further target elimination strategies and surveillance. METHODS: A 1-year prospective cohort study (n = 429) was performed in three rural communities in Quang Nam province...
April 27, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29703185/retrospective-analysis-of-risk-factors-of-slide-positivity-among-febrile-patients-in-the-salween-river-valley-of-shan-special-region-ii-northern-myanmar
#15
Hui Liu, Jian-Wei Xu, Qi-Zhang Xu, Yi-Rou Zeng
BACKGROUND: In Myanmar, epidemiological conditions have been unclear due to a lack of accurate data. In 2014 and 2016, malaria outbreaks occurred in the Shan Special Region II (SSR2). It was reported that these outbreaks were caused by malaria patients from the Salween River Valley (SRV), but further research is needed to confirm these reports. To examine the risks of malaria infection in the SSR2 section of the SRV, this paper offers a retrospective analysis based on the data we collected in 2009...
April 27, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29702253/infectious-disease-profiles-of-syrian-and-eritrean-migrants-presenting-in-europe-a-systematic-review
#16
Egon Isenring, Jan Fehr, Nejla Gültekin, Patricia Schlagenhauf
BACKGROUND: In the past decade, a large influx of migrants presented in Europe. Their country of origin was mainly either Syria or Eritrea. Public health institutions in host countries in Europe are challenged to screen and care for migrant populations with regard to infectious diseases. METHODS: We performed a systematic literature review (according to PRISMA guidelines) to define the infectious disease profile of migrants originating in Syria and Eritrea. RESULTS: The search resulted in 825 papers of possible relevance for infectious diseases in migrants from Syria, of which, after screening, we included 35 in the systematic review...
April 24, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29695527/development-and-evaluation-of-a-novel-lamp-assay-for-the-diagnosis-of-cutaneous-and-visceral-leishmaniasis
#17
Emily Rebecca Adams, Gerard Schoone, Inge Versteeg, Maria Adelaida Gomez, Ermias Diro, Yasuyoshi Mori, Desiree Perlee, Tim Downing, Nancy Saravia, Ashenafi Assaye, Asrat Hailu, Audrey Albertini, Joseph Mathu Ndung'u, Henk Schallig
INTRODUCTION: A novel Pan-Leishmania LAMP assay was developed for diagnosis of Cutaneous and Visceral Leishmaniasis (CL & VL) which can be used in near-patient settings. METHODS: Primers were designed on the 18S rDNA and the conserved region of minicircle kDNA selected on the basis of high copy number. LAMP assays were evaluated for CL in a prospective cohort trial of 105 patients in South-West Colombia. Lesion swab samples from CL suspects were collected and tested using LAMP and compared to a composite reference of microscopy AND/OR culture to calculate diagnostic accuracy...
April 25, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29692310/gametocyte-development-and-carriage-in-ghanaian-individuals-with-uncomplicated-plasmodium-falciparum-malaria
#18
Bismarck Dinko, Felix Ansah, Comfort Agyare-Kwabi, Senyo Tagboto, Linda Eva Amoah, Britta C Urban, Colin J Sutherland, Gordon A Awandare, Kim C Williamson, Fred N Binka, Kirk W Deitsch
Plasmodium falciparum gametocytes develop over 9-12 days while sequestered in deep tissues. On emergence into the bloodstream, they circulate for varied amounts of time during which certain host factors might influence their further development. We aimed to evaluate the potential association of patient clinical parameters with gametocyte development and carriage via in vivo methods. Seventy-two patients were enrolled from three hospitals in the Volta region of Ghana in 2016. Clinical parameters were documented for all patients, and gametocyte prevalence by microscopy was estimated at 12...
April 23, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29681410/development-of-a-bivalent-conjugate-vaccine-candidate-against-malaria-transmission-and-typhoid-fever
#19
So Jung An, Puthupparampil V Scaria, Beth Chen, Emma Barnafo, Olga Muratova, Charles Anderson, Lynn Lambert, Myung Hwa Chae, Jae Seung Yang, Patrick E Duffy
Immune responses to poorly immunogenic antigens, such as polysaccharides, can be enhanced by conjugation to carriers. Our previous studies indicate that conjugation to Vi polysaccharide of Salmonella Typhi may also enhance immunogenicity of some protein carriers. We therefore explored the possibility of generating a bivalent vaccine against Plasmodium falciparum malaria and typhoid fever, which are co-endemic in many parts of the world, by conjugating Vi polysaccharide, an approved antigen in typhoid vaccine, to Pfs25, a malaria transmission blocking vaccine antigen in clinical trials...
April 19, 2018: Vaccine
https://www.readbyqxmd.com/read/29678190/neonatal-and-congenital-malaria-a-case-series-in-malaria-endemic-eastern-uganda
#20
Peter Olupot-Olupot, Emma I E Eregu, Ketty Naizuli, Julie Ikiror, Linda Acom, Kathy Burgoine
BACKGROUND: Congenital malaria is the direct infection of an infant with malaria parasites from their mother prior to or during birth. Neonatal malaria is due to an infective mosquito bite after birth. Neonatal and congenital malaria (NCM) are potentially life-threatening conditions that are believed to occur at relatively low rates in malaria endemic regions. However, recent reports suggest that the number of NCM cases is increasing, and its epidemiology remains poorly described. NCM can mimic other neonatal conditions and because it is thought to be rare, blood film examinations for malaria are not always routinely performed...
April 20, 2018: Malaria Journal
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