keyword
https://read.qxmd.com/read/37334767/the-association-of-intraleucocytic-malaria-pigment-and-disease-severity-in-papua-new-guinean-children-with-severe-p-falciparum-malaria
#21
JOURNAL ARTICLE
Elvin Lufele, Laurens Manning, Lina Lorry, Jonathan Warrel, Susan Aipit, Leanne J Robinson, Moses Laman
BACKGROUND: Plasmodium falciparum pigment-containing leucocytes (PCLs) are associated with adverse clinical manifestations of severe malaria in African children. However, limited data exist on the association of PCLs in settings outside of Africa. METHODS: Thin films on peripheral blood slides obtained from children ages 6 months-10 y with severe malaria were examined for PCLs. The intraleucocytic pigment data were correlated with clinical phenotypic data such as severe anaemia, metabolic acidosis and coma to determine the association of PCLs with clinical phenotypes of severe malaria and outcome...
June 19, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/37219006/omip-93-a-41-color-high-parameter-panel-to-characterize-various-co-inhibitory-molecules-and-their-ligands-in-the-lymphoid-and-myeloid-compartment-in-mice
#22
JOURNAL ARTICLE
Johannes Brandi, Carsten Wiethe, Mathias Riehn, Thomas Jacobs
This 41-color panel has been designed to characterize both the lymphoid and the myeloid compartments in mice. The number of immune cells isolated from organs is often low, whilst an increasing number of factors need to be analyzed to gain a deeper understanding of the complexity of an immune response. With a focus on T cells, their activation and differentiation status, as well as their expression of several co-inhibitory and effector molecules, this panel also allows the analysis of ligands to these co-inhibitory molecules on antigen-presenting cells...
May 23, 2023: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://read.qxmd.com/read/37195999/distinct-immune-responses-associated-with-vaccination-status-and-protection-outcomes-after-malaria-challenge
#23
JOURNAL ARTICLE
Damian A Oyong, Fergal J Duffy, Maxwell L Neal, Ying Du, Jason Carnes, Katharine V Schwedhelm, Nina Hertoghs, Seong-Hwan Jun, Helen Miller, John D Aitchison, Stephen C De Rosa, Evan W Newell, M Juliana McElrath, Suzanne M McDermott, Kenneth D Stuart
Understanding immune mechanisms that mediate malaria protection is critical for improving vaccine development. Vaccination with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) induces high level of sterilizing immunity against malaria and serves as a valuable tool for the study of protective mechanisms. To identify vaccine-induced and protection-associated responses during malarial infection, we performed transcriptome profiling of whole blood and in-depth cellular profiling of PBMCs from volunteers who received either PfRAS or noninfectious mosquito bites, followed by controlled human malaria infection (CHMI) challenge...
May 17, 2023: PLoS Pathogens
https://read.qxmd.com/read/37141324/plasmodium-falciparum-infected-erythrocyte-co-culture-with-the-monocyte-cell-line-thp-1-does-not-trigger-production-of-soluble-factors-reducing-brain-microvascular-barrier-function
#24
JOURNAL ARTICLE
Janet Storm, Grazia Camarda, Michael J Haley, David Brough, Kevin N Couper, Alister G Craig
Monocytes contribute to the pro-inflammatory immune response during the blood stage of a Plasmodium falciparum infection, but their precise role in malaria pathology is not clear. Besides phagocytosis, monocytes are activated by products from P. falciparum infected erythrocytes (IE) and one of the activation pathways is potentially the NLR family pyrin domain containing 3 (NLRP3) inflammasome, a multi-protein complex that leads to the production of interleukin (IL)-1β. In cerebral malaria cases, monocytes accumulate at IE sequestration sites in the brain microvascular and the locally produced IL-1β, or other secreted molecules, could contribute to leakage of the blood-brain barrier...
2023: PloS One
https://read.qxmd.com/read/37060041/the-ability-of-interleukin-10-to-negate-haemozoin-related-pro-inflammatory-effects-has-the-potential-to-restore-impaired-macrophage-function-associated-with-malaria-infection
#25
JOURNAL ARTICLE
Dumizulu Tembo, Visopo Harawa, Tam C Tran, Louise Afran, Malcolm E Molyneux, Terrie E Taylor, Karl B Seydel, Tonney Nyirenda, David G Russell, Wilson Mandala
BACKGROUND: Although pro-inflammatory cytokines are involved in the clearance of Plasmodium falciparum during the early stages of the infection, increased levels of these cytokines have been implicated in the pathogenesis of severe malaria. Amongst various parasite-derived inducers of inflammation, the malarial pigment haemozoin (Hz), which accumulates in monocytes, macrophages and other immune cells during infection, has been shown to significantly contribute to dysregulation of the normal inflammatory cascades...
April 14, 2023: Malaria Journal
https://read.qxmd.com/read/36978912/antioxidant-anti-inflammatory-and-anti-diabetic-activities-of-tectona-grandis-methanolic-extracts-fractions-and-isolated-compounds
#26
JOURNAL ARTICLE
Mei Han, Fengxian Yang, Kun Zhang, Jiyan Ni, Xia Zhao, Xuelin Chen, Zhennan Zhang, Hanlei Wang, Jing Lu, Yumei Zhang
Tectona grandis is a traditional Dai medicine plant belonging to the Lamiaceae family, which can be used to treat malaria, inflammation, diabetes, liver disease, bronchitis, tumors, cholelithiasis, jaundice, skin disease and as an anti-helminthic. To find more novel therapeutic agents contained in this medicinal plant, the antioxidant, anti-inflammatory and anti-diabetic activities of T. grandis methanolic extract, fractions and compounds were evaluated. In this study, 26 compounds were isolated from the leaves and branches of T...
March 8, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36931472/mechanistic-insights-into-immunopathogenesis-of-murine-cerebral-malaria-cues-from-young-c57bl-6j-and-balb-c-mice
#27
JOURNAL ARTICLE
Shweta Rai, Meetali Girdhar, Fouzia Siraj, Sheetal Sharma, Mukesh Kumar, Anju Katyal
Cerebral malaria (CM), a major cause of mortality in children <5 years, presents disparity in pathophysiological features and poor prognosis compared to adults. Adult C57BL/6J mice infected with Plasmodium berghei ANKA (PbA) are widely used to understand CM pathogenesis compared to relatively less prone BALB/c mice; however, age and immune status of the host also influence disease sequelae and cerebral manifestations. Murine models of CM known so far do not project complete disease spectrum of pediatric CM...
March 15, 2023: Immunology Letters
https://read.qxmd.com/read/36820809/the-enemy-within-lipid-asymmetry-in-intracellular-parasite-host-interactions
#28
JOURNAL ARTICLE
Merryn Fraser, Kai Matuschewski, Alexander G Maier
Eukaryotic pathogens with an intracellular parasitic lifestyle are shielded from extracellular threats during replication and growth. In addition to many nutrients, parasites scavenge host cell lipids to establish complex membrane structures inside their host cells. To counteract the disturbance of the host cell plasma membrane they have evolved strategies to regulate phospholipid asymmetry. In this review, the function and importance of lipid asymmetry in the interactions of intracellular protozoan parasites with the target and immune cells of the host are highlighted...
February 23, 2023: Emerging Topics in Life Sciences
https://read.qxmd.com/read/36768950/differential-effect-of-extracellular-vesicles-derived-from-plasmodium-falciparum-infected-red-blood-cells-on-monocyte-polarization
#29
JOURNAL ARTICLE
Ladawan Khowawisetsut, Sinmanus Vimonpatranon, Kittima Lekmanee, Hathai Sawasdipokin, Narinee Srimark, Kesinee Chotivanich, Kovit Pattanapanyasat
Malaria is a life-threatening tropical arthropod-borne disease caused by Plasmodium spp. Monocytes are the primary immune cells to eliminate malaria-infected red blood cells. Thus, the monocyte's functions are one of the crucial factors in controlling parasite growth. It is reasoned that the activation or modulation of monocyte function by parasite products might dictate the rate of disease progression. Extracellular vesicles (EVs), microvesicles, and exosomes, released from infected red blood cells, mediate intercellular communication and control the recipient cell function...
January 30, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36766633/high-plasma-levels-of-neopterin-are-associated-with-increased-mortality-among-children-with-severe-malaria-in-benin
#30
JOURNAL ARTICLE
Samuel Odarkwei Blankson, Lauriane Rietmeyer, Patrick Tettey, Liliane Dikroh, Bernard Tornyigah, Rafiou Adamou, Azizath Moussiliou, Caroline Padounou, Annick Amoussou, Benedicta Ayiedu Mensah, Maroufou J Alao, Gordon Awandare, Nicaise Tuikue Ndam, Christian Roussilhon, Rachida Tahar
Among the barriers to accessing adequate treatment and high-level monitoring for malaria febrile patients is the lack of effective prognostic markers. Neopterin, which is a marker of monocyte/macrophage activation, was found have increased during severe malaria. In this study, we used quantitative ELISA in order to assess the levels of plasma soluble neopterin in 151 patients from a cohort of Beninese children with severe malaria. We evaluated the prognostic accuracy of this molecule in order to predict the outcome of the disease...
January 31, 2023: Diagnostics
https://read.qxmd.com/read/36622216/plasmodium-berghei-purified-hemozoin-associated-with-dna-strongly-inhibits-p-berghei-liver-stage-development-in-balb-c-mice-after-intravenous-inoculation
#31
JOURNAL ARTICLE
Adriano Franco, Yevel Flores-Garcia, Fidel Zavala, David J Sullivan
In the acidic lysosome-like digestive vacuole, Plasmodium parasites crystallize heme from hemoglobin into hemozoin, or malaria pigment. Upon release of progeny merozoites, the residual hemozoin is phagocytized by macrophages principally in the liver and spleen where the heme crystals can persist for months to years, as heme oxygenase does not readily degrade the crystal. Previous studies demonstrated hemozoin modulation of monocytes and macrophages. Hemozoin modulates immune function activity of monocytes/macrophages...
January 9, 2023: Infection and Immunity
https://read.qxmd.com/read/36563075/-discovering-uncommon-nephropathies-a-case-of-acute-kidney-damage-from-malaria
#32
Francesca Chiappo, Loretta Zambianchi, Alessandra Spazzoli, Maria Francesca Lifrieri, Stefania Cristino, Marco De Fabritiis, Claudio Americo, Maria Laura Angelini, Benedetta Fabbrizio, Giovanna Cenacchi, Giovanni Mosconi
Malaria is one of the most common infectious diseases in the world with a high prevalence in developing countries. Renal impairment occurs in 40% of Plasmodium falciparum infections; glomeruli, tubules or interstitium can be involved with different pathophysiological mechanisms. We describe a case of severe acute renal failure caused by P. falciparum malaria in a young woman from the Ivory Coast. Renal biopsy revealed severe and widespread acute tubular necrosis and the presence of blackish pigment granules in the glomerular and peritubular capillaries, negative for iron histochemical staining; in electron microscopy we found rounded-oval-shaped structures containing cytoplasmic organelles, electrondensic granules and cellular debris, likely of infectious origin, within monocyte-macrophages located in the tubular lumen...
October 31, 2022: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://read.qxmd.com/read/36396745/uptake-of-plasmodium-chabaudi-hemozoin-drives-kupffer-cell-death-and-fuels-superinfections
#33
JOURNAL ARTICLE
Isabella C Hirako, Maísa Mota Antunes, Rafael Machado Rezende, Natália Satchiko Hojo-Souza, Maria Marta Figueiredo, Thomaz Dias, Helder Nakaya, Gustavo Batista Menezes, Ricardo Tostes Gazzinelli
Kupffer cells (KCs) are self-maintained tissue-resident macrophages that line liver sinusoids and play an important role on host defense. It has been demonstrated that upon infection or intense liver inflammation, KCs might be severely depleted and replaced by immature monocytic cells; however, the mechanisms of cell death and the alterations on liver immunity against infections deserves further investigation. We explored the impact of acute Plasmodium infection on KC biology and on the hepatic immune response against secondary infections...
November 17, 2022: Scientific Reports
https://read.qxmd.com/read/36384279/evaluation-of-pharmacokinetics-biodistribution-and-antimalarial-efficacy-of-artemether-loaded-polymeric-nanorods
#34
JOURNAL ARTICLE
Atharva R Bhide, Mansi Suri, Sapna Katnoria, Sukhbir Kaur, Yugandhara B Jirwankar, Vikas D Dighe, Anil B Jindal
Artemether oily injection is recommended for the treatment of severe malaria by the intramuscular route. The major limitations of the artemisinin combination therapy are erratic absorption from the injection site and high dosing frequency due to a very short elimination half-life of the drug. Advanced drug delivery systems have shown significant improvement in the current malaria therapy; the desired drug concentration within infected erythrocytes is yet the major challenge. Recently, we have reported the fabrication of artemether-loaded polymeric nanorods for intravenous malaria therapy which was found to be biocompatible with THP-1 monocytes and rat erythrocytes...
November 17, 2022: Molecular Pharmaceutics
https://read.qxmd.com/read/36380373/multicohort-transcriptome-analysis-of-whole-blood-identifies-robust-human-response-signatures-in-plasmodium-falciparum-infections
#35
JOURNAL ARTICLE
Yan-Hui Zhang, Xin-Zhuan Su, Jian Li, Jia-Jian Shi, Li-Hua Xie
BACKGROUND: To understand how Plasmodium falciparum malaria is controlled, it is essential to elucidate the transcriptomic responses of the human host in naturally-exposed populations. Various individual studies of the human transcriptomic responses to naturally transmitted P. falciparum infections have been reported with varying results. Multicohort gene expression analysis by aggregating data from diverse populations into a single analysis will increase the reproducibility and reliability of the results...
November 15, 2022: Malaria Journal
https://read.qxmd.com/read/36371433/the-prognostic-and-diagnostic-value-of-intraleukocytic-malaria-pigment-in-patients-with-severe-falciparum-malaria
#36
JOURNAL ARTICLE
Ketsanee Srinamon, James A Watson, Kamolrat Silamut, Benjamas Intharabut, Nguyen Hoan Phu, Pham Thi Diep, Kirsten E Lyke, Caterina Fanello, Lorenz von Seidlein, Kesinee Chotivanich, Arjen M Dondorp, Nicholas P J Day, Nicholas J White
Severe falciparum malaria is a major cause of death in tropical countries, particularly in African children. Rapid and accurate diagnosis and prognostic assessment are critical to clinical management. In 6027 prospectively studied patients diagnosed with severe malaria we assess the prognostic value of peripheral blood film counts of malaria pigment containing polymorphonuclear leukocytes (PMNs) and monocytes. We combine these results with previously published data and show, in an individual patient data meta-analysis (n = 32,035), that the proportion of pigment containing PMNs is predictive of in-hospital mortality...
November 12, 2022: Nature Communications
https://read.qxmd.com/read/36310859/kinetics-of-monocyte-subpopulations-during-experimental-cerebral-malaria-and-its-resolution-in-a-model-of-late-chloroquine-treatment
#37
JOURNAL ARTICLE
Jade Royo, Aissata Camara, Benedicte Bertrand, Philippe Batigne, Agnes Coste, Bernard Pipy, Agnes Aubouy
Cerebral malaria (CM) is one of the most severe forms of malaria and is a neuropathology that can lead to death. Monocytes have been shown to accumulate in the brain microvasculature at the onset of neurological symptoms during CM. Monocytes have a remarkable ability to adapt their function to their microenvironment from pro-inflammatory to resolving activities. This study aimed to describe the behavior of monocyte subpopulations during infection and its resolution. C57BL/6 mice were infected with the Plasmodium berghei ANKA strain and treated or not with chloroquine (CQ) on the first day of the onset of neurological symptoms (day 6) for 4 days and followed until day 12 to mimic neuroinflammation and its resolution during experimental CM...
2022: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/36232861/gene-signatures-associated-with-temporal-rhythm-as-diagnostic-markers-of-major-depressive-disorder-and-their-role-in-immune-infiltration
#38
JOURNAL ARTICLE
Jing Wang, Pan Ai, Yi Sun, Hui Shi, Anshi Wu, Changwei Wei
Temporal rhythm (TR) is involved in the pathophysiology and treatment response of major depressive disorder (MDD). However, there have been few systematic studies on the relationship between TR-related genes (TRRGs) and MDD. This study aimed to develop a novel prognostic gene signature based on the TRRGs in MDD. We extracted expression information from the Gene Expression Omnibus (GEO) database and retrieved TRRGs from GeneCards. Expressed genes (TRRDEGs) were identified differentially, and their potential biological functions were analyzed...
September 30, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36207868/-correlation-analysis-between-lactic-procalcitonin-and-disease-severity-in-patients-with-imported-malaria-from-africa
#39
JOURNAL ARTICLE
S H Du, Y X Li, Y J Liu, T Liang, W J Lai, Y Liu, X L Deng
Objective: To explore the clinical characteristics, the correlation between lactate, procalcitonin and disease severity of imported malaria from Africa. Methods: The clinical data of 186 patients with imported malaria were collected from January 1, 2018 to April 30, 2021 in the Guangzhou Eighth People's Hospital, Guangzhou Medical University. The general conditions, clinical symptoms, laboratory tests, treatment, and prognosis of the patients were analyzed retrospectively. Receiver operating characteristic (ROC) curves were drawn to evaluate the value of relevant indicators in predicting severe malaria...
October 11, 2022: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/36136633/leukocyte-and-igm-responses-to-immunization-with-the-cidr1%C3%AE-pfemp1-recombinant-protein-in-the-wistar-rat
#40
JOURNAL ARTICLE
Erma Sulistyaningsih, Renaldi Wibisono, Rosita Dewi
The malaria vaccine is an important strategy for the global malaria elimination program, but the complexity of the Plasmodium antigen is a major hurdle in malaria vaccine development. The cysteine-rich interdomain region 1α (CIDR1α) of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is crucial in malaria pathogenesis, making it a vaccine candidate. This study investigated the leukocyte and IgM response generated after administering a CIDR1α-PfEMP1 recombinant protein injection in Wistar rats...
September 2, 2022: Tropical Medicine and Infectious Disease
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