keyword
MENU ▼
Read by QxMD icon Read
search

Heat shock protein 70

keyword
https://www.readbyqxmd.com/read/29684601/the-effect-of-intermittent-hypoxia-under-different-temperature-on-the-immunomodulation-in-streptococcus-agalactiae-vaccinated-nile-tilapia-oreochromis-niloticus
#1
Jing Wang, Dan-Qi Lu, Biao Jiang, Heng-Li Luo, Ge-Ling Lu, An-Xing Li
Dissolved oxygen (DO) and temperature are the potential immunomodulators in fish and play the important roles in regulating immunity. We studied the effect of intermittent hypoxia under different temperature on the immunomodulation in vaccinated Nile tilapia (Oreochromis niloticus). The expression of immune-related genes, enzymatic activities, histology, cumulative mortality, and S. agalactiae clearance were assessed. Study conditions were intermittently hypoxic (4.0 ± 1.0 mg/L DO) at 30 ± 0.5 °C or 35 ± 0...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684060/moyvh1-subverts-rice-defense-through-functions-of-ribosomal-protein-momrt4-in-magnaporthe-oryzae
#2
Xinyu Liu, Jie Yang, Bin Qian, Yongchao Cai, Xi Zou, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang
The accumulation of the reactive oxygen species (ROS) in rice is important in its interaction with the rice blast fungus Magnaporthe oryzae during which the pathogen scavenges ROS through the production of extracellular enzymes that promote blast. We previously characterized the MoYvh1 protein phosphatase from M. oryzae that plays a role in scavenging of ROS. To understand the underlying mechanism, we found that MoYvh1 is translocated into the nucleus following oxidative stress and that this translocation is dependent on MoSsb1 and MoSsz1 that are homologous to heat-shock protein 70 (Hsp70) proteins...
April 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29679484/the-role-of-autoimmune-reactivity-induced-by-heat-shock-protein-70-in-the-pathogenesis-of-essential-hypertension
#3
REVIEW
Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
Autoimmunity is increasingly recognized as having a central role in essential hypertension. Heat shock proteins are immunodominant molecules with high interspecies homology and autoimmune reactivity directed against HSP70 may play a role in the pathogenesis of hypertension. Autoimmunity to HSP70 may result from molecular mimicry between human HSP and bacterial HSP, or alternatively, as a response to HSP70-peptide complexes generated during cellular stress and delivered to the major histocompatibility complex in antigen presenting cells...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29678721/acute-tissue-reactions-inner-segment-pathology-and-effects-of-the-antioxidant-%C3%AE-1-microglobulin-in-an-in-vitro-model-of-retinal-detachment
#4
Fredrik Ghosh, Bo Åkerström, Jesper Bergwik, Hodan Abdshill, Lina Gefors, Linnéa Taylor
The purpose of this study was to explore acute tissue reactions, ultrastructural photoreceptor morphology with emphasis on inner segments, and the effect of antioxidant treatment in an in vitro model of rhegmatogenous retinal detachment (RRD). A previously described method of RRD simulation was used with adult retinal porcine explants kept free-floating in culture medium with or without treatment with the radical scavenger α1 -microglobulin (A1M). Explants were examined at 5 time points from 1 to 24 h using transmission electron microscopy as well as quantitative real-time PCR (RT-PCR) to quantify gene expression of the cell stress marker heat shock protein 70 (Hsp70) and oxidative stress marker heme oxygenase (HO-1)...
April 17, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29678642/heat-shock-protein-70-accelerates-atherosclerosis-by-downregulating-the-expression-of-abca1-and-abcg1-through-the-jnk-elk-1-pathway
#5
Zhen-Wang Zhao, Min Zhang, Ling-Yan Chen, Duo Gong, Xiao-Dan Xia, Xiao-Hua Yu, Si-Qi Wang, Xiang Ou, Xiao-Yan Dai, Xi-Long Zheng, Da-Wei Zhang, Chao-Ke Tang
BACKGROUND AND AIMS: Recent studies have suggested that heat shock protein 70 (HSP70) may play critical roles in cardiovascular disease. However, the effects of HSP70 on the development of atherosclerosis in apoE-/- mice remain largely unknown. This study was to investigate the role and potential mechanism of HSP70 in atherosclerosis. METHODS: HSP70 was overexpressed in apoE-/- mice and THP-1-derived macrophages with lentiviral vectors. Oil Red O, hematoxylin-eosin, and Masson staining were performed to evaluate atherosclerotic plaque in apoE-/- mice fed the Western type diet...
April 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29676863/nitrite-stress-disrupts-the-structural-integrity-and-induces-oxidative-stress-response-in-the-intestines-of-pacific-white-shrimp-litopenaeus-vannamei
#6
Yafei Duan, Jiasong Zhang, Yun Wang, Qingsong Liu, Dalin Xiong
The acute toxicity of nitrite on the mucosal morphology and oxidative stress response was investigated in the intestines of Litopenaeus vannamei after the exposure of 20 mg/L nitrite for 72 hr. The duration of nitrite stress influenced the shrimp survival, and the cumulative mortality rate was 36.7% at 72 hr. Hematoxylin and eosin (HE) stain showed that nitrite stress damaged the intestine connective and epithelium tissue. Specifically, nitrite stress increased the content of reactive oxygen species (ROS) production (O2 - generation capacity), lipid peroxidation (LPO), and malondialdehyde (MDA)...
April 20, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29675023/increased-plasma-levels-of-danger-associated-molecular-patterns-are-associated-with-immune-suppression-and-postoperative-infections-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#7
Guus P Leijte, Hettie Custers, Jelle Gerretsen, Amon Heijne, Johannes Roth, Thomas Vogl, Gert J Scheffer, Peter Pickkers, Matthijs Kox
Introduction: Danger-associated molecular patterns (DAMPs) can elicit immune responses and may subsequently induce an immune-suppressed state. Previous work showed that increased plasma levels of DAMPs are associated with immune suppression and increased susceptibility toward infections in trauma patients. Like trauma, major surgical procedures, such as cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC), are also thought to cause profound DAMP release...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29673284/reducing-myeloperoxidase-activity-decreases-inflammation-and-increases-cellular-protection-in-ischemic-stroke
#8
Hyeon J Kim, Ying Wei, Gregory R Wojtkiewicz, Ji Y Lee, Michael A Moskowitz, John W Chen
Myeloperoxidase (MPO) is a pro-inflammatory enzyme abundantly secreted by activated myeloid cells after stroke. We show that when MPO activity is either blocked by the specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) in wildtype (WT) mice or congenitally absent (MPO-/- ), there was decreased cell loss, including degenerating neurons and oligodendrocytes, in the ischemic brains compared to vehicle-treated WT mice after stroke. MPO inhibition also reduced the number of activated myeloid cells after ischemia...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29667911/experimental-heat-stress-nephropathy-and-liver-injury-are-improved-by-allopurinol
#9
Carlos A Roncal-Jimenez, Yuka Sato, Tamara Milagres, Ana Andres-Hernando, Gabriela E Garcia, Petter Bjornstad, Jaime Butler-Dawson, Cecilia Sorensen, Lee Newman, Lyndsay Krisher, Magdalena Madero, Jason Glaser, Ramon Garcia-Trabannino, Emmanuel Jarquin-Romero, Zhilin Song, Thomas Jensen, Masanari Kuwabara, Bernardo Rodriguez-Iturbe, Laura-Gabriela Sanchez-Lozada, Miguel A Lanaspa, Richard J Johnson
BACKGROUND: An epidemic of chronic kidney disease (CKD) has been observed in Central America among workers in the sugarcane fields. One hypothesis is that the CKD may be caused by recurrent heat stress and dehydration, and potentially by hyperuricemia. Accordingly, we developed a murine model of kidney injury associated with recurrent heat stress. In the current experiment, we tested whether treatment with allopurinol (a xanthine oxidase inhibitor that reduces serum urate) provides renal protection against recurrent heat stress and dehydration...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29663990/-expression-and-role-of-heat-shock-protein-70-and-apoptosis-related-proteins-in-muscle-tissue-of-pressure-injury
#10
Nan Zhang, Haiyan Liu, Yan Qu
OBJECTIVE: To observe the phenomenon of apoptosis and expression of related proteins in injured muscle tissue during the formation of pressure injury, and to explore its mechanism of action on the pressure injury. METHODS: Forty male Sprague-Dawley (SD) rats were divided into normal control group, 3, 5, 7 and 9 compression groups according to the random number table, with 8 rats in each group. The pressure injury models on the gracilis muscle of hind limbs were reproduced by using a way of cycle compression of ischemia/reperfusion (I/R) magnet...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29659877/cytosolic-phosphoenolpyruvate-carboxykinase-is-a-response-gene-involved-in-porcine-adipocyte-adaptation-to-heat-stress
#11
H Qu, K M Ajuwon
Heat stress (HS) leads to increased lipid storage and expression of cytosolic phosphoenolpyruvate carboxykinase (PCK1) in pig adipocytes. However, the importance of PCK1 activation and lipid storage in the adaptive response to heat stress is unknown. Therefore, in vitro experiments were conducted to investigate the effect of PCK1 inhibition with 3-mercaptopicolinic acid (3MPA) on lipid storage and adipocyte response during HS. In vitro culture of adipocytes under heat stress (41.0 °C) increased (P < 0.05) triacylglycerol (TAG) accumulation compared with control (37...
April 6, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29651925/heptamer-peptide-disassembles-native-amyloid-in-human-plasma-via-heat-shock-protein-70
#12
Timothy James Cunningham, Jeffrey I Greenstein, Lihua Yao, Itzhak Fischer, Theresa Conners
Proteostasis, which includes the repair and disposal of misfolded proteins, depends in part on the activity of heat shock proteins, a well-known class of chaperone molecules. When this process fails abnormally folded proteins may accumulate in cells, tissues, and blood. These species are a hallmark of protein aggregation diseases but also amass during aging, often in the absence of an identified clinical disorder. We report that a neuroprotective cyclic heptapeptide, CHEC-7, which has been applied systemically as a therapeutic in animal neurodegeneration models, disrupts such aggregates and inhibits amyloidogenesis when added in nanomolar concentrations to human plasma...
April 13, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29649272/in-field-and-in-vitro-study-of-the-moss-leptodictyum-riparium-as-bioindicator-of-toxic-metal-pollution-in-the-aquatic-environment-ultrastructural-damage-oxidative-stress-and-hsp70-induction
#13
Sergio Esposito, Stefano Loppi, Fabrizio Monaci, Luca Paoli, Andrea Vannini, Sergio Sorbo, Viviana Maresca, Lina Fusaro, Elham Asadi Karam, Marco Lentini, Alessia De Lillo, Barbara Conte, Piergiorgio Cianciullo, Adriana Basile
This study evaluates the effects of toxic metal pollution in the highly contaminated Sarno River (South Italy), by using the aquatic moss Leptodictyum riparium in bags at 3 representative sites of the river. Biological effects were assessed by metal bioaccumulation, ultrastructural changes, oxidative stress, as Reactive Oxygen Species (ROS) production and Glutathione S-transferase (GST) activity, as well as Heat Shock Proteins 70 (HSP70s) induction. The results showed that L. riparium is a valuable bioindicator for toxic metal pollution of water ecosystem, accumulating different amounts of toxic metals from the aquatic environment...
2018: PloS One
https://www.readbyqxmd.com/read/29626669/the-effects-of-feeding-lactobacillus-pentosus-on-growth-immunity-and-disease-resistance-in-haliotis-discus-hannai-ino
#14
Gao Xiaolong, Zhang Mo, Li Xian, Han Yin, Wu Fucun, Liu Ying
To study the effects of probiotic-added food on the survival and growth of abalone (Haliotis discus hannai Ino), the expression levels of nonspecific immune genes and the anti-Vibrio parahaemolyticus infection were examined. During an 8-week culturing experiment in an indoor aquarium and a 2-week V. parahaemolyticus artificial infection experiment, the control group was fed with untreated food once a day, while the experimental groups (L1, L2 and L3) were fed with Lactobacillus pentosus added food. The concentration of probiotics in the experimental food was 103  cfu/g (L1), 105  cfu/g (L2) and 107  cfu/g (L3), respectively...
April 4, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29625344/response-of-antioxidant-enzymes-to-cd-and-pb-exposure-in-water-flea-daphnia-magna-differential-metal-and-age-specific-patterns
#15
Haeyeon Kim, Ji-Soo Kim, Pyoung-Joong Kim, Eun-Ji Won, Young-Mi Lee
To investigate oxidative stress responses to cadmium and lead, the freshwater water flea Daphnia magna was exposed to Cd and Pb for 48 h. Following treatment with sub-lethal concentrations, intracellular reactive oxygen species (ROS) levels, as well as modulation of multiple biomarker, such as superoxide dismutase (SOD) activity, glutathione (GSH) contents, glutathione S-transferase (GST) activity, antioxidant enzyme - coding genes (three GST isoforms, glutaredoxin [GRx], glutathione peroxidase [GPx], and thioredoxin [TRx]), and stress-response proteins (heat shock protein 70 [Hsp70] and Hsp90) were examined...
April 3, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29623929/quinacrine-pretreatment-reduces-microwave-induced-neuronal-damage-by-stabilizing-the-cell-membrane
#16
Xue-Feng Ding, Yan Wu, Wen-Rui Qu, Ming Fan, Yong-Qi Zhao
Quinacrine, widely used to treat parasitic diseases, binds to cell membranes. We previously found that quinacrine pretreatment reduced microwave radiation damage in rat hippocampal neurons, but the molecular mechanism remains poorly understood. Considering the thermal effects of microwave radiation and the protective effects of quinacrine on heat damage in cells, we hypothesized that quinacrine would prevent microwave radiation damage to cells in a mechanism associated with cell membrane stability. To test this, we used retinoic acid to induce PC12 cells to differentiate into neuron-like cells...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29622083/role-of-drug-transporters-and-heat-shock-proteins-during-ethanol-exposure-to-human-neural-precursor-cells-and-its-lineages
#17
Sandeep Kumar Vishwakarma, Nusrath Fatima, Chandrakala Lakkireddy, Nagarapu Raju, Avinash Bardia, A Sandhya, Syed Ameer Basha Paspala, Vishnupriya Satti, Aleem Ahmed Khan
INTRODUCTION: Ethanol exposure to developing brain may alter the growth and differentiation of neurological cells resulting in unfavorable pathologies. Earlier studies have provided very limited mechanistic insights of cellular and molecular mechanisms which do not mimic with human situation due to varying cell types and poses potential challenges for investigation. Therefore, the present study was undertaken to evaluate the role of ABC transporters and heat shock proteins mediated response in human neural precursor cells (NPCs) and its lineages during proliferation and lineage differentiation against ethanol exposure...
April 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29616455/topical-heat-shock-protein-70-prevents-imiquimod-induced-psoriasis-like-inflammation-in-mice
#18
Federico G Seifarth, Julia E-M Lax, Jennifer Harvey, Paul E DiCorleto, M Elaine Husni, Unnikrishnan M Chandrasekharan, Michael Tytell
Psoriasis is a chronic inflammatory skin disease with systemic manifestations and potential genetic etiology. The newest treatments utilize antibodies against one of several cytokines known to underlie the inflammatory signaling molecules that produce the skin and systemic symptoms. However, these agents must be regularly injected, and they may compromise the normal responses of the immune system. Furthermore, they do not address the causes of the abnormal immunoregulatory responses of the disease because the etiology is not yet completely understood...
April 3, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29615414/suppression-of-mir-26a-attenuates-physiological-disturbances-arising-from-exposure-of-nile-tilapia-oreochromis-niloticus-to-ammonia
#19
Yan Zhao, Haotian Zhou, Christian Larbi Ayisi, Yan Wang, Jun Wang, Xiaowu Chen, Jinling Zhao
MicroRNAs may affect stress responses because they act as rapid responders at the post-translation level. In this study, we found that miR-26a is abundantly expressed in brain and gill tissues of tilapia. Expression of miR-26a in the brains decreased significantly with increasing ammonia concentrations using stem-loop qPCR. To analyze the function of miRNA in vivo, miR-26a was stably knocked down with an antagomir in tilapia. Following ammonia challenge, miR-26a antagomir treatment significantly suppressed blood ammonia / [Cl- ] / [K+ ] concentration and the reactive oxygen species production, while markedly enhanced glutamine accumulation and antioxidant enzyme activity in the brain of tilapia, indicating that miR-26a may be involved in the remission of physiological disturbances upon ammonia stress...
April 3, 2018: Biology Open
https://www.readbyqxmd.com/read/29614969/27-hydroxycholesterol-increases-%C3%AE-synuclein-protein-levels-through-proteasomal-inhibition-in-human-dopaminergic-neurons
#20
Jared Schommer, Gurdeep Marwarha, Trevor Schommer, Travis Flick, Jonah Lund, Othman Ghribi
BACKGROUND: Accumulation of the α-synuclein (α-syn) protein is a hallmark of a group of brain disorders collectively known as synucleinopathies. The mechanisms responsible for α-syn accumulation are not well understood. Several studies suggest a link between synucleinopathies and the cholesterol metabolite 27-hydroxycholesterol (27-OHC). 27-OHC is the major cholesterol metabolite in the blood that crosses the blood brain barrier, and its levels can increase following hypercholesterolemia, aging, and oxidative stress, which are all factors for increased synucleinopathy risk...
April 3, 2018: BMC Neuroscience
keyword
keyword
33025
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"