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Heat shock protein 70

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https://www.readbyqxmd.com/read/29454917/marine-derived-xyloketal-derivatives-exhibit-anti-stress-and-anti-ageing-effects-through-hsf-pathway-in-caenorhabditis-elegans
#1
Jie-Bin Zhou, Ying-Lin Zheng, Yi-Xuan Zeng, Jia-Wei Wang, Zhong Pei, Ji-Yan Pang
Ageing is a complex but universal phenomenon that progressively challenges the homeostasis network and finally leads to the dysfunction of organisms and even death. Previous studies demonstrated that xyloketal B and its derivatives, a series of marine novel ketone compounds, possessed unique antioxidative effects on endothelial and neuronal oxidative injuries. In this study, we examined the effects of xyloketal derivatives on extending lifespan and healthspan of Caenorhabditis elegans. The results showed that most selected xyloketals could protect Caenorhabditis elegans against heat stress and extend the lifespan of worms...
February 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29454898/dietary-values-of-forsythia-suspensa-extract-in-penaeus-monodon-under-normal-rearing-and-vibrio-parahaemolyticus-3hp-vp-3hp-challenge-conditions-effect-on-growth-intestinal-barrier-function-immune-response-and-immune-related-gene-expression
#2
Jia-Jun Xie, Xu Chen, Tian-Yu Guo, Shi-Wei Xie, Hao-Hang Fang, Zhen-Lu Liu, Yan-Mei Zhang, Li-Xia Tian, Yong-Jian Liu, Jin Niu
Two trials were conducted to determine the effects of dietary Forsythia suspensa extract (FSE) on shrimp, Penaeus monodon, first on growth performance, second on the immune response and immune related gene expression of shrimp. In trial 1, shrimp (mean initial wet weight about 3.02 g) were fed with five diets containing 0% (basal diet), 0.01%, 0.02%, 0.04% and 0.06% FSE in triplicate for 60 days. Growth performance (final body wet weight, FBW; weight gain, WG; biomass gain, BG) of shrimp fed FSE diets were higher (P < 0...
February 15, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29454858/expression-of-heat-shock-protein-70-and-cell-death-kinetics-after-different-thermal-impacts-on-cultured-retinal-pigment-epithelial-cells
#3
Katharina Kern, Carla-Lotta Mertineit, Ralf Brinkmann, Yoko Miura
Recent technologies are broadening the possibility to treat the retinal pigment epithelium (RPE) with different thermal impacts, from sublethal to lethal ranges. Thus temperature-dependent subcellular molecular responses need to be elucidated in more detail. In this study, RPE cell viability and expression of heat shock protein 70 (Hsp70) were investigated after thermal irradiation with different temperature increase using an in-vitro model. Primary porcine RPE cell cultures were irradiated with different laser power of a thulium laser (λ = 1940 nm, beam-diameter 30 mm) for 10 s, such that the maximal temperatures at the center of the culture dish (Tmax ) reach 40, 44, 47, 51 or 59 °C after 10s' irradiation...
February 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29454324/investigation-of-the-anti-cataractogenic-mechanisms-of-curcumin-through-in-vivo-and-in-vitro-studies
#4
Jing Cao, Tao Wang, Meng Wang
BACKGROUND: Cataract is the leading cause of blindness in elderly people worldwide, especially in developing countries. Studies to identify strategies that can prevent or retard cataract formation are urgently required. This study aimed to investigate the potential mechanism of the cytoprotective effects of curcumin in in vivo and in vitro experiments. METHODS: Male Wistar rats were randomly divided into three groups: the control group, the model group (administered 20 μmol/kg sodium selenite), and the curcumin group (pretreated with 75 mg/kg body weight curcumin 24 h prior to the administration of sodium selenite)...
February 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29445274/endoplasmic-reticulum-chaperone-grp78-mediates-cigarette-smoke-induced-necroptosis-and-injury-in-bronchial-epithelium
#5
Yong Wang, Jie-Sen Zhou, Xu-Chen Xu, Zhou-Yang Li, Hai-Pin Chen, Song-Min Ying, Wen Li, Hua-Hao Shen, Zhi-Hua Chen
Introduction: Bronchial epithelial cell death and airway inflammation induced by cigarette smoke (CS) have been involved in the pathogenesis of COPD. GRP78, belonging to heat shock protein 70 family, has been implicated in cell death and inflammation, while little is known about its roles in COPD. Here, we demonstrate that GRP78 regulates CS-induced necroptosis and injury in bronchial epithelial cells. Materials and methods: GRP78 and necroptosis markers were examined in human bronchial epithelial (HBE) cell line, primary mouse tracheal epithelial cells, and mouse lungs...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29444421/chloroplast-signaling-gates-thermotolerance-in-arabidopsis
#6
Patrick J Dickinson, Manoj Kumar, Claudia Martinho, Seong Jeon Yoo, Hui Lan, George Artavanis, Varodom Charoensawan, Mark Aurel Schöttler, Ralph Bock, Katja E Jaeger, Philip A Wigge
Temperature is a key environmental variable influencing plant growth and survival. Protection against high temperature stress in eukaryotes is coordinated by heat shock factors (HSFs), transcription factors that activate the expression of protective chaperones such as HEAT SHOCK PROTEIN 70 (HSP70); however, the pathway by which temperature is sensed and integrated with other environmental signals into adaptive responses is not well understood. Plants are exposed to considerable diurnal variation in temperature, and we have found that there is diurnal variation in thermotolerance in Arabidopsis thaliana, with maximal thermotolerance coinciding with higher HSP70 expression during the day...
February 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29435724/transcriptome-expression-and-activity-analyses-reveal-a-vital-heat-shock-protein-70-in-the-stress-response-of-stony-coral-pocillopora-damicornis
#7
Yidan Zhang, Zhi Zhou, Lingui Wang, Bo Huang
Coral bleaching occurs worldwide with increasing frequencies and intensities, which is caused by the stress response of stony coral to environmental change, especially increased sea surface temperature. In the present study, transcriptome, expression, and activity analyses were employed to illustrate the underlying molecular mechanisms of heat shock protein 70 (HSP70) in the stress response of coral to environmental changes. The domain analyses of assembled transcripts revealed 30 HSP70 gene contigs in stony coral Pocillopora damicornis...
February 12, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29432736/mir-223-hsp70-jnk-jun-mir-223-feedback-loop-modulates-the-chemoresistance-of-osteosarcoma-to-cisplatin
#8
Qi Tang, Qi Yuan, Hui Li, Wanchun Wang, Guangrong Xie, Kewei Zhu, Ding Li
Osteosarcoma (OS) is a primary bone malignancy with a five-year survival rate of 60%; the chemoresistance of OS still remains a huge challenge. Heat shock protein 70 (Hsp70), a member of HSP family, is overexpressed in OS cell lines and involved in the resistance of OS cell lines. In addition, miRNAs have been involved in the carcinogenesis and chemoresistance of OS; of them, miR-223 has been reported to be underexpressed and serve as a tumor suppressor in OS through targeting Hsp90B1, also a member of HSP family...
February 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29430372/analysis-of-differential-transcript-expression-in-chickpea-during-compatible-and-incompatible-interactions-with-fusarium-oxysporum-f-sp-ciceris-race-4
#9
Parasappa R Saabale, Sunil C Dubey, Kumari Priyanka, Tilak R Sharma
The present study reports the transcriptome analysis of resistance (WR315) and susceptible (JG62) genotypes of chickpea in response to Fusarium oxysporum f. sp. ciceris (Foc) race 4 using the method of suppression subtractive hybridization. Altogether, 162 chickpea-expressed sequence tags (ESTs) were identified from two libraries and analyzed to catalog eight functional categories. These ESTs could be assembled into 18 contigs and 144 singletons with 10 contigs and 68 singletons from compatible and 8 contigs and 70 singletons from incompatible interaction...
February 2018: 3 Biotech
https://www.readbyqxmd.com/read/29421932/the-70-kda-heat-shock-protein-hsp70-as-a-therapeutic-target-for-stroke
#10
Jong Youl Kim, Yeonseung Han, Jong Eun Lee, Midori A Yenari
The 70-kDa heat shock protein (Hsp70) is a cytosolic chaperone which facilitates protein folding, degradation, complex assembly, and translocation. Following stroke, these functions have the potential to lead to cytoprotection, and this has been demonstrated using genetic mutant models, direct gene transfer or the induction of Hsp70 via heat stress, approaches which limit its translational utility. Recently, the investigation of Hsp70-inducing pharmacological compounds, which, through their ability to inhibit Hsp90, has obvious clinical implications in terms of potential therapies to mitigate cell death and inflammation, and lead to neuroprotection from brain injury...
February 8, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29421306/prenatal-cold-stress-effect-on-maternal-hippocampus-and-offspring-behavior-in-rats
#11
Shuai Lian, Di Wang, Bin Xu, Wenjin Guo, Lipeng Wang, Wenjie Li, Hong Ji, Jianfa Wang, Fanzhi Kong, Li Zhen, Shize Li, Liping Zhang, Jingru Guo, Huanmin Yang
In mammals, environmental factors including cold stress exert dramatic effects on adult health during late gestation, the cold stress response refers to an organism's response to cold. Indeed, cells and organs, including the hippocampus, are coordinated to respond to prevent hypothermia. The hippocampus act as an important brain structure that regulates the activity of the hypothalamic-pituitary-adrenal (HPA) axis, and suppress the stress reaction through feedback regulation of the HPA axis. To evaluate the response of the hippocampus during prenatal cold stress, we established a prenatal cold stress rat model...
February 5, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29421151/fractional-excretion-as-a-new-marker-of-tubular-damage-in-children-with-chronic-kidney-disease
#12
Kinga Musiał, Danuta Zwolińska
OBJECTIVES: Vitamin D-binding protein (VDBP), retinol-binding protein (RBP)4, and heat shock proteins (hsp) are markers of tubular function and apoptosis, accompanying chronic kidney disease (CKD) from its earliest stages. Fractional excretion of proteins with urine is a marker of tubular damage. The aim of study was to assess the usefulness of fractional excretion (FE) of VDBP, RBP4, HSF1 and Hsp27 as markers of tubular damage in the course of CKD. METHODS: The study group consisted of 70 children with CKD stages 1-5, treated conservatively, and 12 age-matched controls with normal kidney function...
February 6, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29416499/a-metadata-analysis-of-oxidative-stress-etiology-in-preclinical-amyotrophic-lateral-sclerosis-benefits-of-antioxidant-therapy
#13
Leila Bond, Kamren Bernhardt, Priyank Madria, Katherine Sorrentino, Hailee Scelsi, Cassie S Mitchell
Oxidative stress, induced by an imbalance of free radicals, incites neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). In fact, a mutation in antioxidant enzyme superoxide dismutase 1 (SOD1) accounts for 20% of familial ALS cases. However, the variance among individual studies examining ALS oxidative stress clouds corresponding conclusions. Therefore, we construct a comprehensive, temporal view of oxidative stress and corresponding antioxidant therapy in preclinical ALS by mining published quantitative experimental data and performing metadata analysis of 41 studies...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29414793/high-throughput-screen-for-inhibitors-of-protein-protein-interactions-in-a-reconstituted-heat-shock-protein-70-hsp70-complex
#14
Isabelle R Taylor, Bryan M Dunyak, Tomoko Komiyama, Hao Shao, Xu Ran, Victoria A Assimon, Chakrapani Kalyanaraman, Jennifer N Rauch, Matthew P Jacobson, Erik R P Zuiderweg, Jason E Gestwicki
Protein-protein interactions (PPIs) are an important category of putative drug targets. Improvements in high throughput screening (HTS) have significantly accelerated the discovery of inhibitors for some categories of PPIs. However, methods suitable for screening multi-protein complexes (e.g. those composed of three or more different components) have been slower to emerge. Here, we explored an approach that uses reconstituted multi-protein complexes (RMPCs). As a model system, we chose heat shock protein 70 (Hsp70), which is an ATP-dependent molecular chaperone that interacts with co-chaperones, including DnaJA2 and BAG2...
February 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29409719/comparison-of-heat-shock-protein-70%C3%A2-kda-and-18s-rdna-genes-for-molecular-detection-and-phylogenetic-analysis-of-babesia-vogeli-from-whole-blood-of-naturally-infected-dogs
#15
Patrícia G Paulino, Marcus S Pires, Claudia B da Silva, Maristela Peckle, Renata L da Costa, Gabriela L V Vitari, Ana Paula M de Abreu, Nádia R P Almosny, Carlos L Massard, Huarrisson A Santos
A total of 300 blood samples of domiciliated dogs in rural and urban areas of southeast Rio de Janeiro State, Brazil, were used to compare the 18S ribosomal DNA region (18S rDNA) and the heat shock protein 70 kDa (hsp70) gene for molecular detection of Babesia vogeli and to perform a phylogenetic study comparing the two genes for B. vogeli classification. Using conventional polymerase chain reaction (cPCR) of 18S rDNA and hsp70 sequences, we were able to detect B. vogeli with the same sensitivity (96.15%) and specificity (99...
February 1, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29402790/unravelling-pathophysiology-of-crystalline-nephropathy-in-ceftriaxone-associated-acute-kidney-injury-a-cellular-proteomic-approach
#16
Supawat Chatchen, Nutkridta Pongsakul, Chantragan Srisomsap, Wararat Chiangjong, Suradej Hongeng, Jisnuson Svasti, Somchai Chutipongtanate
BACKGROUND: Previous studies showed that ceftriaxone can cause acute kidney injury (AKI) in the pediatric population. This study proposed a cellular model of crystalline nephropathy in ceftriaxone-associated AKI and explored the related pathophysiology by using a proteomic approach. METHODS: Ceftriaxone was crystallized with calcium in artificial urine. Madin-Darby Canine Kidney (MDCK) cells, a model of distal renal tubular cell, were cultured in the absence (untreated control) or presence of ceftriaxone crystals for 48-h (n = 5 each)...
January 16, 2018: Nephron
https://www.readbyqxmd.com/read/29396434/cooperation-between-hsp90-and-mortalin-grp75-in-resistance-to-cell-death-induced-by-complement-c5b-9
#17
Perri Rozenberg, Lea Ziporen, Dana Gancz, Moran Saar-Ray, Zvi Fishelson
Cancer cells are commonly more resistant to cell death activated by the membranolytic protein complex C5b-9. Several surface-expressed and intracellular proteins that protect cells from complement-dependent cytotoxicity (CDC) have been identified. In this study, we investigated the function of heat shock protein 90 (Hsp90), an essential and ubiquitously expressed chaperone, overexpressed in cancer cells, in C5b-9-induced cell death. As shown, inhibition of Hsp90 with geldanamycin or radicicol is enhancing sensitivity of K562 erythroleukemia cells to CDC...
February 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29395577/hsp72-functionally-inhibits-the-anti-neoplastic-effects-of-hdac-inhibitors
#18
Kazuyasu Fujii, Norihiro Suzuki, Nozomi Jimura, Masashi Idogawa, Tadashi Kondo, Keiji Iwatsuki, Takuro Kanekura
BACKGROUND: The anticancer effects of histone deacetylase inhibitors (HDACi) vary between patients, and their molecular mechanisms remain poorly understood. Previously, we have identified heat shock 70 kDa protein 1A (HSPA1A, also known as HSP72) as the most overexpressed protein in valproic acid (VPA)-resistant cell lines. KNK437, an inhibitor of heat shock proteins, enhanced the cytotoxic effects of not only VPA but also vorinostat, another HDACi. However, the mechanisms underlying the role of HSP72 in resistance against HDACi remain largely unknown...
January 30, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29394239/matrine-protects-cardiomyocytes-from-ischemia-reperfusion-injury-by-regulating-hsp70-expression-via-activation-of-the-jak2-stat3-pathway
#19
Suping Guo, Chuanyu Gao, Wentao Xiao, Jing Zhang, Yongsheng Qu, Jiang Li, Famin Ye
Studies have shown that matrine showed cardiovascular protective effects; however, its role and mechanism in myocardial ischemia/reperfusion (I/R) injury remain unknown. The Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway activation and elevated heat shock protein (HSP) 70 are closely related to the prevention of myocardial I/R injury. The cardioprotective effects of matrine were determined in hypoxia/reoxygenation (H/R) treated primary rat cardiomyocytes and left anterior descending coronary artery ligation and reperfusion animal models...
February 1, 2018: Shock
https://www.readbyqxmd.com/read/29385708/differential-glycosylation-and-modulation-of-camel-and-human-hsp-isoforms-in-response-to-thermal-and-hypoxic-stresses
#20
Abdullah Hoter, Mahdi Amiri, Abdelbary Prince, Hassan Amer, Mohamad Warda, Hassan Y Naim
Increased expression of heat shock proteins (HSPs) following heat stress or other stress conditions is a common physiological response in almost all living organisms. Modification of cytosolic proteins including HSPs by O-GlcNAc has been shown to enhance their capabilities for counteracting lethal levels of cellular stress. Since HSPs are key players in stress resistance and protein homeostasis, we aimed to analyze their forms at the cellular and molecular level using camel and human HSPs as models for efficient and moderate thermotolerant mammals, respectively...
January 30, 2018: International Journal of Molecular Sciences
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