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https://www.readbyqxmd.com/read/29441995/short-term-curative-effect-of-s-1-plus-oxaliplatin-as-perioperative-chemotherapy-for-locally-advanced-gastric-cancer-a-prospective-comparison-study
#1
Qun Zhao, Yong Li, Jian Huang, Liqiao Fan, Bibo Tan, Yuan Tian, Peigang Yang, Zhikai Jiao, Xuefeng Zhao, Zhidong Zhang, Dong Wang, Yu Liu
This research aimed to investigate the efficacy of S-1 plus oxaliplatin (SOX) as perioperative chemotherapy for locally advanced gastric cancer. We enrolled 102 patients with preoperative clinical stage T3-4N×M0 gastric cancer who were then randomly assigned to receive SOX as either perioperative chemotherapy (group A, 50 patients) or postoperative adjuvant chemotherapy (group B, 52 patients). Short-term curative efficacy and adverse effects of perioperative chemotherapy were analyzed. The rates of R0 resection, surgical complications, combined multiple organ resection, overall survival (OS), and disease-free survival (DFS) were compared between the groups...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441461/superficially-spreading-signet-ring-cell-carcinoma-perpendicularly-colliding-with-gastric-adenoma-a-rare-case-report
#2
Takayuki Minami, Norihiro Yuasa, Eiji Takeuchi, Hideo Miyake, Hidemasa Nagai, Kanji Miyata, Ayami Kiriyama
No abstract text is available yet for this article.
February 14, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29438363/cd9-positive-exosomes-from-cancer-associated-fibroblasts-stimulate-the-migration-ability-of-scirrhous-type-gastric-cancer-cells
#3
Yuichiro Miki, Masakazu Yashiro, Tomohisa Okuno, Kishu Kitayama, Go Masuda, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Crosstalk between cancer cells and fibroblasts is crucial for tumour progression. It has been reported that exosomes derived from cancer cells play an important role in the intracellular communications involved in the development of carcinoma. However, the role of exosomes from fibroblasts remains unclear. This study aimed to clarify the effect of exosomes from fibroblasts on the motility of gastric cancer cells. METHODS: 5 gastric cancer cell lines were used: OCUM-12, NUGC-3, MKN45, FU97 and MKN74...
February 13, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29438173/fallopian-tube-mucosal-involvement-in-cervical-gastric-type-adenocarcinomas-report-of-a-series-with-discussion-of-the-distinction-from-synchronous-in-situ-tubal-lesions
#4
Simon Rajendran, Yaser Hussein, Kay J Park, W Glenn McCluggage
Cervical gastric-type adenocarcinomas are aggressive non-human papillomavirus-related carcinomas with a propensity for extracervical spread, including unusual sites such as the omentum, peritoneum, and ovary. We report 7 cases of cervical gastric-type adenocarcinoma with fallopian tube involvement predominantly in the form of mucosal colonization without underlying invasion. As far as we are aware, this has not been previously described and this report adds to the literature regarding metastatic neoplasms, which may exhibit tubal mucosal involvement and mimic an in situ lesion at this site...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29438172/gastric-carcinomas-with-lymphoid-stroma-an-evaluation-of-the-histopathologic-and-molecular-features
#5
Erika Hissong, Girish Ramrattan, Pan Zhang, Xi Kathy Zhou, Gloria Young, David S Klimstra, Jinru Shia, Helen Fernandes, Rhonda K Yantiss
Gastric carcinoma with lymphoid stroma is an uncommon variant enriched for mutually exclusive Epstein-Barr virus (EBV) positivity and mismatch repair (MMR) deficiency. We performed this study to evaluate molecular alterations in this morphologically homogeneous subtype and compare them with 295 conventional gastric cancers analyzed in The Cancer Genome Atlas study. We identified 31 study cases and subjected them to in situ hybridization for EBV-encoded RNAs and assessment for MMR status. Immunostains for PD-L1, β-catenin, and HER2 were performed; extracted DNA was sequenced with a Comprehensive Cancer Panel...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29438113/morphologic-and-immunohistochemical-appraisal-of-primary-gastric-carcinomas
#6
Gunes Guner, Aynur Isik, Erdem Karabulut, Gokhan Gedikoglu, Cenk Sokmensuer, Aytekin Akyol
Gastric carcinoma management requires adjustments answering their genetic and morphologic heterogeneity. We aim to assess the expression and significance of a myriad of biomarkers (p53, MLH1, MSH2, PMS2, MSH6, Epstein-Barr encoding region-RNA, c-erbB2, E-cadherin, CEA, chromogranin, Ki-67, CDX2, presenilin-1, cathepsin E, MUC5AC, cyclin-dependent kinase 1) in 117 gastric carcinomas, which we have morphologically subclassified with a simple algorithm. Immunohistochemical stains were applied to 3 tissue microarrays of primary gastric carcinomas (n=117) obtained from resection specimens of untreated patients...
February 12, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29436592/concomitant-modulation-of-pten-and-livin-in-gastric-cancer-treatment
#7
Chun-Lin Zhao, Sheng-Na Han, Zhi-Ju Wang, Shu-Hui Wang, Guo-Qiang Zhao, Xie-Fu Zhang, Jia-Xiang Wang
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and Livin are important in the development of gastric cancer (GC). PTEN and Livin are involved in the regulation of tumor cell proliferation, migration and apoptosis. The modulation of PTEN or Livin has been investigated extensively in various cancer models. However, no studies have been performed to evaluate the combined effect of concurrently modulating these two genes on the development of GC. In the present study, the BGC823 human gastric carcinoma cell line was transfected with a dual gene modified vector (pCL-neo-PTEN-siLivin) in parallel with single gene modified vectors (pCL‑neo‑PTEN or pRNAT‑U6...
February 8, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29435146/upregulation-of-lncrna-bcyrn1-promotes-tumor-progression-and-enhances-epcam-expression-in-gastric-carcinoma
#8
Hao Ren, Xiaomin Yang, Yongmei Yang, Xiaoyu Zhang, Rui Zhao, Ran Wei, Xin Zhang, Yi Zhang
Brain cytoplasmic RNA 1 (BCYRN1), along non-coding RNA, plays a critical role in various diseases, including some cancers. However, the expression of BCYRN1 and its roles in gastric carcinoma (GC) still remain unidentified. Thus, this study employed RT-qPCR to detect expression of BCYRN1 in 85 paired GC samples and adjacent normal tissues, and performed in vitro studies to explore effects of BCYRN1 in GC cells on cell proliferation, apoptosis and migration. We found BCYRN1 was significantly upregulated in GC samples, and its expression was positively correlated with advanced TNM stage (p = 0...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435059/macc1-and-hgf-are-associated-with-survival-in-patients-with-gastric-cancer
#9
Guokai Dong, Man Wang, Guangfu Gu, Shanshan Li, Xiaoming Sun, Zhouru Li, Hongxing Cai, Zhengqiu Zhu
Metastasis-associsated in colon cancer 1 (MACC1), a newly identified oncogene, promotes tumor cell proliferation and invasion. In the present study, the expression of MACC1, hepatocyte growth factor (HGF) and its receptor, MET proto-oncogene (c-Met), was investigated in human gastric cancer tissues and adjacent normal tissues by immunohistochemistry. The association between the expression levels of the proteins and the clinicopathological parameters of the tumors were statistically analyzed. Furthermore, lentiviral particles expressing MACC1 were used to infect the hepatic satellite cell (HSC) line LX2...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29435040/prostate-stem-cell-antigen-is-expressed-in-normal-and-malignant-human-brain-tissues
#10
Hiroe Ono, Hiromi Sakamoto, Teruhiko Yoshida, Norihisa Saeki
Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein and exhibits an organ-dependent expression pattern in cancer. PSCA is upregulated in prostate cancer and downregulated in gastric cancer. PSCA is expressed in a variety of human organs. Although certain studies previously demonstrated its expression in the mammalian and avian brain, its expression in the human brain has not been thoroughly elucidated. Additionally, it was previously reported that PSCA is weakly expressed in the astrocytes of the normal human brain but aberrantly expressed in glioma, suggesting that PSCA is a promising target of glioma therapy and prostate cancer therapy...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434991/mechanism-of-the-anti-angiogenic-effect-of-avemar-on-tumor-cells
#11
Nilüfer Gülmen Imir, Esra Aydemir, Ece Şimşek
Avemar, a derivative of fermented wheat germ extract, is a non-toxic and natural compound that is used as a dietary supplement by cancer patients undergoing chemotherapy and radiotherapy. Avemar has numerous biological activities, and several recent studies have reported that it may also have metastatic and anti-angiogenic effects. In the present study, the mechanism of the anti-angiogenic effect of Avemar on human cancer cells was investigated. The human cell lines NCI-N87 (gastric tubular adenocarcinoma), PC3 (prostate carcinoma), HeLa (endocervical adenocarcinoma) and A549 (lung adenocarcinoma) were treated with various doses (400, 800, 1,600 and 3,200 µg/ml) of Avemar, and the changes in mRNA and protein levels of two important markers of angiogenesis, vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (Cox-2), were assessed by reverse transcription-quantitative polymerase chain reaction and ELISA...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434732/sustained-multiple-organ-ischaemia-after-transarterial-chemoembolization-with-drug-eluting-beads-for-hepatocellular-carcinoma
#12
Young Woon Kim, Jung Hyun Kwon, Soon Woo Nam, Jeong Won Jang, Hyun Suk Jung, Yu Ri Shin, Eun Su Park, Dong Jae Shim
Transarterial chemoembolization (TACE) with drug-eluting beads (DC beads) may enhance drug delivery to tumours and reduce systemic toxicity. TACE with DC beads leads to significantly fewer serious side-effects compared with conventional TACE. A 66-year-old man with hepatocellular carcinoma (HCC) complained of continuous abdominal pain 1 month after TACE with DC beads. At the time of TACE, angiography revealed severe stenosis of both hepatic arteries. The diagnostic work up on admission suggested severe bile duct injury with regional bile duct dilatation, segmental liver and spleen infarction, necrotizing pancreatitis, as well as gastric and duodenal ulcers...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434495/carcinosarcoma-of-stomach-confined-to-the-mucosa
#13
Hirohiko Kuroda, Hiroaki Saito, Yusuke Kono, Yuki Murakami, Yuji Shishido, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Kanae Nosaka, Yoshihisa Umekita, Yoshiyuki Fujiwara
Carcinosarcoma is a malignant tumor composed of both epithelial and mesenchymal malignant tumor components. A 78-year-old man was transferred to our hospital because of hematemesis and tarry stool. An emergency gastrointestinal endoscopic examination revealed active bleeding from an ulcerative lesion on the posterior wall of the gastric body; endoscopic hemostasis was successfully performed. A gastrointestinal endoscopy performed two months later showed a polypoid lesion at the same place where the ulcer had been...
December 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/29434448/promotion-of-sema4d-expression-by-tumor-associated-macrophages-significance-in-gastric-carcinoma
#14
Han Li, Jin-Shen Wang, Lin-Jun Mu, Ke-Shu Shan, Le-Ping Li, Yan-Bing Zhou
AIM: To study the role of semaphorin 4D (Sema4D) expression promoted by tumor-associated macrophages (TAMs) in gastric carcinoma cells and its clinical significance in the invasion and metastasis of gastric carcinoma. METHODS: CD68 and Sema4D expression was analyzed in gastric carcinoma and adjacent normal tissues from 290 patients using the immunohistochemical streptavidin-peroxidase method, and their relationships with clinicopathological features were evaluated...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29434119/a-case-of-helicobacter-pylori-negative-advanced-gastric-cancer-with-massive-eosinophilia
#15
Atsushi Takagi, Hideki Ozawa, Masayuki Oki, Hidetaka Yanagi, Kazuhito Nabeshima, Naoto Nakamura
The incidence of Helicobacter pylori-negative gastric cancer is very low. A 60-year-old man was referred to Tokai University Hospital from a local clinic because of eosinophilia. The laboratory data revealed prominent eosinophilia, with a white blood cell count of 7,900/μl and increased eosinophil granulocyte level of 1,659/μl. After an examination for secondary eosinophilia, esophagogastroduodenoscopy showed an enlarged gastric fold in the corpus, suggesting type 4 gastric cancer. Repeated EGD and a re-biopsy demonstrated poorly differentiated adenocarcinoma and signet ring cell carcinoma...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29429272/-multivariate-analysis-of-the-association-between-consumption-of-fried-food-and-gastric-cancer-and-precancerous-lesions
#16
L W Guo, S Z Liu, M Zhang, Q Chen, S K Zhang, X B Sun
Objective: To investigate the effect of fried food intake on the pathogenesis of gastric cancer and precancerous lesions. Methods: From 2005 to 2013, the residents aged 40-69 years from 11 counties/cities where cancer screening of upper gastrointestinal cancer were conducted in rural areas of Henan province as the subjects (82 367 cases). The information such as demography and lifestyle was collected. The residents were screened with endoscopic examination. The biopsy sampleswere diagnosed pathologically, according to pathological diagnosis criteria, the subjects with high risk were divided into the groups with different pathological degrees...
February 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29427669/high-kif2a-expression-promotes-proliferation-migration-and-predicts-poor-prognosis-in-lung-adenocarcinoma
#17
Tian Xie, Xingyu Li, Fei Ye, Chenxi Lu, Haitao Huang, Fei Wang, Xiaolei Cao, Chongjun Zhong
The Kinesin family member 2a (KIF2A), that belongs to the Kinesin-13 microtubule depolymerases, plays an important role in cancer cell proliferation, migration and apoptosis in various types of cancer such as gastric cancer, breast cancer, and squamous cell carcinoma of the oral tongue, but, its role and mechanism in lung adenocarcinoma (LUAD) is largely unknown. The present study reported that KIF2A was overexpressed in LUAD tissues as compared with adjacent normal tissues. KIF2A was closely correlated with TNM stage and lymph node metastasis (P < 0...
February 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29425880/protoporphyrinogen-oxidase-is-involved-in-the-fluorescence-intensity-of-5-aminolevulinic-acid-mediated-laser-based-photodynamic-endoscopic-diagnosis-for-early-gastric-cancer
#18
Hiroki Kurumi, Tsutomu Kanda, Koichiro Kawaguchi, Kazuo Yashima, Hiroki Koda, Kumi Ogihara, Kayoko Matsushima, Kazuhiko Nakao, Hiroaki Saito, Yoshiyuki Fujiwara, Mitsuhiko Osaki, Futoshi Okada, Hajime Isomoto
BACKGROUND/AIM: Laser-based photodynamic endoscopic diagnosis (LPDED) is a type of endoscopic diagnosis that uses the fluorescence caused by the photochemical reaction that occurs when a fluorescent substance is irradiated by a light of a specific wavelength. Although 5-aminolevulinic acid (5-ALA) can detect early gastric cancer (EGC) during LPDED, there is an unresolved issue of the differences in fluorescence intensity among histopathological types of gastric cancer. Thus, the aim of the present study was to assess whether protoporphyrinogen oxidase (PPOX), involved in the activation of protoporphyrin IX, can affect the fluorescence intensity in EGC...
February 6, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29424266/silencing-of-lncrna-zfas1-inhibits-malignancies-by-blocking-wnt-%C3%AE-catenin-signaling-in-gastric-cancer-cells
#19
Weiran Xu, Liang He, Ying Li, Yan Tan, Fan Zhang, Hong Xu
Gastric cancer is a common malignancy with high mortality. Long noncoding RNA (lncRNA) zinc finger antisense (ZFAS)1 is upregulated in gastric cancer specimens compared with the para-carcinoma tissues. The silencing of ZFAS1 inhibited the growth, proliferation, cell cycle progress, migration, invasion and epithelial-mesenchymal transition (EMT), and enhanced the sensitivity to cis-platinum or paclitaxel in SGC7901 cells, as evidenced by the expression changes of proliferating cell nuclear antigen, Cyclin D1, Cyclin E, Cyclin B1, E-cadherin, N-cadherin, vimentin, matrix metalloproteinase (MMP)-2 and MMP-14...
February 9, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29417935/hydroxysafflor-yellow-a-induces-human-gastric-carcinoma-bgc-823-cell-apoptosis-by-activating-peroxisome-proliferator-activated-receptor-gamma-ppar%C3%AE
#20
Li Liu, Na Si, YiCong Ma, DongYu Ge, Xue Yu, AngRan Fan, Xu Wang, JingHong Hu, Peng Wei, Long Ma, ZiWei Chen, Qian Zhang, CuiLing Feng
BACKGROUND Anti-tumor properties of hydroxysafflor-yellow A (HSYA) have been recently revealed, as a series of apoptotic factors were confirmed to be regulated by HSYA and associated with peroxisome proliferator-activated receptor Gamma (PPARγ). In this study, we investigated the cell apoptosis mechanism of HSYA via activated PPARγ signal in human gastric carcinoma cells. MATERIAL AND METHODS BGC-823 cells were cultured and divided into 5 independent groups: Tumor, HSYA, HSYA+PPARγ inhibitor (GW9662), and PPARg agonist (RGZ), RGZ+GW9662...
February 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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