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https://www.readbyqxmd.com/read/29027279/long-non-coding-rna-pvt1-emerging-biomarker-in-digestive-system-cancer
#1
REVIEW
Dan-Dan Zhou, Xiu-Fen Liu, Cheng-Wei Lu, Om Prakash Pant, Xiao-Dong Liu
The digestive system cancers are leading cause of cancer-related death worldwide, and have high risks of morbidity and mortality. More and more long non-coding RNAs (lncRNAs) have been studied to be abnormally expressed in cancers and play a key role in the process of digestive system tumour progression. Plasmacytoma variant translocation 1 (PVT1) seems fairly novel. Since 1984, PVT1 was identified to be an activator of MYC in mice. Its role in human tumour initiation and progression has long been a subject of interest...
October 12, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29026322/molecular-classification-of-esophagogastric-junction-carcinoma-correlated-with-prognosis
#2
Long Zou, Yinying Wu, Ke Ma, Yangwei Fan, Danfeng Dong, Ningyan Geng, Enxiao Li
A novel molecular classification of gastric cancer by the Asian Cancer Research Group (ACRG) is a potential advance in diagnosis and treatment, and it helps to determine prognosis. The use of immunohistochemistry (IHC) rather than gene expression analysis to determine tumor subtypes was evaluated with the aim of determining the feasibility of using the ACRG molecular classification. A total of 69 esophagogastric junction (EGJ) carcinomas were classified as microsatellite instable (MSI, 17.40%, 12 of 69), microsatellite stable with markers of epithelial-to-mesenchymal transition (MSS/EMT, 18...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29026319/current-advances-of-long-non-coding-rna-highly-upregulated-in-liver-cancer-in-human-tumors
#3
REVIEW
Zhonghua Ma, Hesuyuan Huang, Yetao Xu, Xuezhi He, Jirong Wang, Bingqing Hui, Hao Ji, Jing Zhou, Keming Wang
Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs (ncRNAs) >200 nucleotides in length that govern diverse biological processes. Recent evidence suggests that lncRNAs are involved in cancer cell proliferation, apoptosis, invasion, migration, and metastasis. Dysregulation of lncRNAs has been observed in various tumors, and lncRNAs act as oncogenes or tumor suppressors in these malignancies. It has been revealed that lncRNA highly upregulated in liver cancer (HULC) is tightly correlated with a number of cancers such as hepatocellular carcinoma, gastric cancer, colorectal cancer, osteosarcoma, and diffuse large B-cell lymphoma...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29022892/the-lncrna-hulc-functions-as-an-oncogene-by-targeting-atg7-and-itgb1-in-epithelial-ovarian-carcinoma
#4
Shuo Chen, Dan-Dan Wu, Xiu-Bo Sang, Li-Li Wang, Zhi-Hong Zong, Kai-Xuan Sun, Bo-Liang Liu, Yang Zhao
Highly upregulated in liver cancer (HULC) is a long noncoding RNA (lncRNA), which has recently been identified as a key regulator in the progression of hepatocellular carcinoma, gliomas and gastric cancer. However, its role in epithelial ovarian carcinoma (EOC) remains unknown. In this study, HULC expression was examined in EOC, borderline and benign ovarian tumors, and normal ovarian tissues by RT-PCR. Ovarian cancer cell phenotypes, as well as autophagy-associated proteins were examined after HULC overexpression or downregulation by plasmid or small interfering RNA (siRNA) transfection, respectively...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29021786/a-new-role-for-helicobacter-pylori-urease-contributions-to-angiogenesis
#5
Deiber Olivera-Severo, Augusto F Uberti, Miguel S Marques, Marta T Pinto, Maria Gomez-Lazaro, Céu Figueiredo, Marina Leite, Célia R Carlini
Helicobacter pylori is a pathogen involved in gastric diseases such as ulcers and carcinomas. H. pylori's urease is an important virulence factor produced in large amounts by this bacterium. In previous studies, we have shown that this protein is able to activate several cell types like neutrophils, monocytes, platelets, endothelial cells, and gastric epithelial cells. Angiogenesis is a physiological process implicated in growth, invasion and metastization of tumors. Here, we have analyzed the angiogenic potential of H...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29019570/thoraco-laparoscopic-esophagectomy-thoracic-stage-in-prone-position
#6
Carlos Bernardo Cola, Flávio Duarte Sabino, Carlos Eduardo Pinto, Maria Ribeiro Morard, Pedro Portari, Tereza Guedes
OBJECTIVE: to analyze the National Cancer Institute Abdominopelvic Division (INCA / MS/HC I) initial experience with thoraco-laparoscopic esophagectomy with thoracic stage in prone position. METHODS: we studied 19 consecutive thoraco-laparoscopic esophagectomies from may 2012 to august 2014, including ten patients with squamous cells carcinoma (five of the middle third and five of the lower third) and nine cases of gastroesophageal junction adenocarcinoma (six Siewert I and three Siewert II)...
September 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28993866/cdh1-mutation-screen-in-a-brca1-2-negative-familial-breast-ovarian-cancer-cohort
#7
Frederik Stuebs, Simone Heidemann, Almuth Caliebe, Christoph Mundhenke, Norbert Arnold
PURPOSE: Mutations in the CDH1 gene are linked both to diffuse gastric cancer and invasive lobular carcinoma (ILC). A high mutation rate is found in families fulfilling the diagnostic criteria for hereditary diffuse gastric cancer. Aim of this study was to clarify whether or not there is a significant contribution of CDH1 mutations in hereditary breast-/ovarian cancer (HBOC). METHODS: Ninety-seven unrelated probands fulfilling the diagnostic criteria for HBOC (96 affected, 1 unaffected) but tested negative for pathogenic BRCA1/2 mutations were screened for CDH1 mutations by denaturing high performance liquid chromatography (DHPLC) and subsequent Sanger sequencing of suspicious and positive DHPLC results...
October 9, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28990284/the-oncogenic-role-of-epstein-barr-virus-encoded-micrornas-in-epstein-barr-virus-associated-gastric-carcinoma
#8
REVIEW
Jinglin Zhang, Tingting Huang, Yuhang Zhou, Alfred S L Cheng, Jun Yu, Ka Fai To, Wei Kang
Epstein-Barr virus (EBV) infection is detected in various epithelial malignancies, such as nasopharyngeal carcinoma (NPC) and gastric cancer (GC). EBV comprises some unique molecular features and encodes viral genes and microRNAs (miRNAs) by its own DNA sequence. EBV genes are required to maintain latency and contribute to oncogenic property. miRNAs encoded by EBV have been shown to contribute to initiation and progression of EBV-related malignancies. By a number of genomic profiling studies, some EBV miRNAs were confirmed to be highly expressed in EBV-associated gastric cancer (EBVaGC) samples and cell lines...
October 9, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28990095/kangfuxin-promotes-apoptosis-of-gastric-cancer-cells-through-activating-er%C3%A2-stress-and-autophagy
#9
Pian-Pian Chen, Xiu-Ying Ma, Qian Lin, He-Lin Xu, Hong-Xue Shi, Hong-Yu Zhang, Jian Xiao, Fu-Neng Geng, Ying-Zheng Zhao
Gastric cancer is a leading cause of cancer‑associated mortality worldwide. In studies on the mechanisms of antigastric cancer drugs, autophagy and endoplasmic reticulum (ER) stress have been demonstrated to serve an active role in gastric cancer. The organic extract of Periplaneta americana (also termed American Cockroach), which is named Kangfuxin (KFX) in China, has been used clinically as a traditional Chinese medicine against disorders, including stomach bleeding, gastric ulcers, tuberculosis, burns and trauma...
October 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28990045/anti%C3%A2-tumor-effects-of-bakuchiol-on-human-gastric-carcinoma-cell-lines-are-mediated-through-pi3k-akt-and-mapk-signaling-pathways
#10
Long Lv, Bo Liu
Bakuchiol is extracted from Psoralea corylifolia, a member of the Leguminosae family, has been used in Indian Ayurvedic and Chinese traditional medicine, and it possesses an anticancer effect. The primary aim of the present study was to identify the molecular mechanisms underlying the anticancer effect of bakuchiol monoterpenes. Bakuchiol treatment significantly inhibited NUGC3 human gastric cancer cell viability in a concentration dependent manner. In addition, bakuchiol significantly increased the apoptotic cell population in the sub‑G1 phase, and Annexin‑V‑fluorescein isothiocyanate/propidium iodide double staining confirmed the increase in apoptosis...
October 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28988405/a-case-of-adenocarcinoma-developed-in-the-small-intestine-with-chronic-strongyloidiasis
#11
Satoshi Ishikawa, Tamaki Maeda, Kimiaki Hattori, Takahiro Watanabe, Takanori Kuramoto, Saori Ueno, Goro Ueno, Tadahiro Yamada, Akifumi Kanazawa, Masahiro Sakaguchi, Yoshitane Tsukamoto
We experienced a case of intestinal strongyloidiasis complicated by jejunal carcinoma. A Japanese male in his 50s, who has a 7-year medical history of duodenal ulcers, complained of loss of appetite, nausea, vomiting and diarrhea. Computed tomography and gastroduodenal endoscopic examination revealed a stenosis of the duodenum. To remove the stenosis, gastric bypass surgery was performed. The pathological diagnosis of the resected jejunum was strongyloidiasis and well-differentiated adenocarcinoma with subserosal invasion and vascular infiltration...
October 7, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28987942/mir-205-regulation-of-ict1-has-an-oncogenic-potential-via-promoting-the-migration-and-invasion-of-gastric-cancer-cells
#12
Youmao Tao, Yan Song, Tao Han, Changjing Wang, Tongquan Zhao, Ye Gu
Immature colon carcinoma transcript-1 (ICT1) is a newly identified oncogene, which regulates mobility, apoptosis, cell cycle progression and proliferation of cancer cells. Nevertheless, the role of ICT1 and its clinical significance in gastric cancer (GC) is largely uncovered. Here, we found that ICT1 displayed higher expression in GC tissues compared to corresponding tumor-adjacent tissues. Further investigation confirmed ICT1 overexpression in GC cell lines. Clinical data disclosed that high ICT1 expression correlated with distant metastasis and advanced tumor-node-metastasis (TNM) stage...
October 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28985030/a-double-edged-sword-the-world-according-to-capicua-in-cancer
#13
REVIEW
Miwa Tanaka, Toyoki Yoshimoto, Takuro Nakamura
CIC/Capicua is a HMG-box transcription factor that is well conserved during evolution. CIC recognizes the T(G/C)AATG(A/G)A sequence and represses its target genes such as PEA3 family genes. The RTK/RAS/MAPK signals downregulate CIC and relieves CIC's target genes from the transrepressional activity, and CIC thus acts as an important downstream molecule of the pathway and as a tumor suppressor. CIC loss-of-function mutations are frequently observed in several human neoplasms such as oligodendroglioma, and lung and gastric carcinoma...
October 6, 2017: Cancer Science
https://www.readbyqxmd.com/read/28983895/lncrna-ghet1-promotes-esophageal-squamous-cell-carcinoma-cells-proliferation-and-invasion-via-induction-of-emt
#14
Hongfen Liu, Qiang Zhen, Yakun Fan
BACKGROUND: Recent studies have shown that long noncoding RNA (lncRNA) gastric carcinoma highly expressed transcript 1 (GHET1) was involved in the progression of tumors. However, the role of GHET1 in esophageal squamous cell carcinoma (ESCC) remains unclear. METHODS: The expression of lncRNA GHET1 was examined in 55 paired ESCC tissues and adjacent nontumor tissues. Molecular and cellular techniques were used to explore the role of GHET1 on ESCC cells. RESULTS: Our data showed that GHET1 expression was significantly increased in ESCC tissues and cell lines...
October 4, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28981387/aldh1a1-and-hltf-modulate-the-activity-of-lysosomal-autophagy-inhibitors-in-cancer-cells
#15
Shengfu Piao, Rani Ojha, Vito W Rebecca, Arabinda Samanta, Xiao-Hong Ma, Quentin Mcafee, Michael C Nicastri, Meghan Buckley, Eric Brown, Jeffrey D Winkler, Phyllis A Gimotty, Ravi K Amaravadi
Lysosomal autophagy inhibitors (LAI) such as hydroxychloroquine (HCQ) have significant activity in a subset of cancer cell lines. LAIs are being evaluated in cancer clinical trials, but genetic determinants of sensitivity to LAIs are unknown, making it difficult to predict which tumors would be most susceptible. Here we characterize differentially expressed genes in HCQ-sensitive (-S) and -resistant (-R) cancer cells. Notably, expression of canonical macroautophagy/autophagy genes was not associated with sensitivity to HCQ...
October 5, 2017: Autophagy
https://www.readbyqxmd.com/read/28979726/safe-use-of-capecitabine-cisplatin-in-metastatic-gastric-carcinoma-with-severe-liver-dysfunction-a-case-report-from-algeria
#16
Lasgaa Meryem, Ghomari Soumia, Boudali Bouchra
Due to its high incidence and poor prognosis, gastric cancer is an important health problem worldwide. The liver is the most frequent site of metastases. Advanced cancer in the setting of liver dysfunction poses a dilemma for physicians, as many cancer chemotherapeutic agents undergo hepatic metabolism. This paper reports the case of a patient with liver failure due to liver metastases of gastric cancer. The initial liver function tests showed an elevation of transaminases (aspartate amino transferase 180 IU/l, alanine aminotransferase 110 UI/l), hyperbilirubinemia (total bilirubin at 24 mg/dl), alkaline phosphatase at 1127 UI/l and elevation of tumor markers (carcinoembryonic antigen >1000 ng/ml and CA19,9 at 180 UI/l)...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28978999/low-dose-yc-1-combined-with-glucose-and-insulin-selectively-induces-apoptosis-in-hypoxic-gastric-carcinoma-cells-by-inhibiting-anaerobic-glycolysis
#17
Kota Wakiyama, Yoshihiko Kitajima, Tomokazu Tanaka, Masao Kaneki, Kazuyoshi Yanagihara, Shinichi Aishima, Jun Nakamura, Hirokazu Noshiro
This study aimed to establish a therapeutic strategy targeting hypoxic cancer cells in gastric carcinoma (GC). YC-1 is a HIF-1α inhibitor, and we revealed that low-dose YC-1 (10 µM) suppressed HIF-1α expression, and induced hypoxia-dependent apoptosis in the GC cell line 58As9. This hypoxia-specific apoptosis induction by YC-1 involved excessive reactive oxygen species (ROS) generation. The apoptotic effect of 10 µM YC-1 was enhanced by additional glucose (G) and insulin (I) treatments. RT-PCR demonstrated that 10 µM YC-1 reduced hypoxia-induced expression of HIF-1α targets involved in anaerobic glycolysis...
October 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28978884/a-case-of-synchronous-quintuple-gastric-cancer-with-large-cell-endocrine-carcinoma
#18
Momotaro Muto, Mizue Muto, Kazuhiko Ichiki, Chisato Ishikawa, Takaaki Hosoki, Mitsutaka Inoue, Junichi Goto, Satoshi Inaba
The patient was a 73-year-old man who visited our department with black stools as the chief complaint. Upper digestive tract endoscopy revealed three type 2 lesions in the lesser curvature of the gastric antrum and the gastric angle and the posterior wall of the upper gastric body, which were diagnosed by biopsy as tub2, por, and sig, respectively. Total gastrectomy was performed. The final pathological diagnosis was quintuple gastric cancer with a main lesion of large-cell endocrine carcinoma and four adenocarcinoma sublesions...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28978106/a-prospective-appraisal-of-preoperative-body-mass-index-in-d2-resected-patients-with-non-metastatic-gastric-carcinoma-and-siewert-type-ii-iii-adenocarcinoma-of-esophagogastric-junction-results-from-a-large-scale-cohort
#19
Lei Huang, Zhi-Jian Wei, Tuan-Jie Li, Yu-Ming Jiang, A-Man Xu
OBJECTIVE: To prospectively investigate associations of presurgical body mass index (BMI) with clinicopathological factors and its prognostic significance in radically D2-resected patients with non-metastasized gastric cancer (GC) and Siewert type II/III adenocarcinoma of esophagogastric junction (AEG). METHODS: A large prospective cohort consisting of radically-resected GC and AEG patients was analyzed. Follow-up was successful in 671 out of 700 patients, who were categorized into underweight (BMI<18...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28978001/tenascin-c-and-fibronectin-in-normal-esophageal-mucosa-barrett-s-esophagus-dysplasia-and-adenocarcinoma
#20
Joni Leppänen, Sara Bogdanoff, Petri P Lehenkari, Juha Saarnio, Joonas H Kauppila, Tuomo J Karttunen, Heikki Huhta, Olli Helminen
BACKGROUND: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is poorly known. The aim of this study was to evaluate the expression of tenascin-C and fibronectin in esophageal adenocarcinoma and its precursor stages. RESULTS: Stromal tenascin-C and fibronectin expression were found in all evaluated lesion types. Expression of both molecules increased from gastric metaplasia towards adenocarcinoma (p<0...
September 15, 2017: Oncotarget
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