keyword
https://read.qxmd.com/read/38491387/characteristics-of-the-oral-and-gastric-microbiome-in-patients-with-early-stage-intramucosal-esophageal-squamous-cell-carcinoma
#1
JOURNAL ARTICLE
Han Chen, Xingzhou Jiang, Fengyi Zhu, Ruoyun Yang, Xin Yu, Xiaoying Zhou, Nana Tang
BACKGROUND: Oral microbiome dysbacteriosis has been reported to be associated with the pathogenesis of advanced esophageal cancer. However, few studies investigated the potential role of oral and gastric microbiota in early-stage intramucosal esophageal squamous carcinoma (EIESC). METHOD: A total of 104 samples were collected from 31 patients with EIESC and 21 healthy controls. The compositions of oral and gastric microbiota were analyzed using 16 S rRNA V3-V4 amplicon sequencing...
March 15, 2024: BMC Microbiology
https://read.qxmd.com/read/38486303/successful-multidisciplinary-treatment-for-synchronous-advanced-esophageal-and-cecal-cancers-after-total-gastrectomy-with-reconstruction-by-jejunal-interposition
#2
JOURNAL ARTICLE
Yuta Sato, Yoshihiro Tanaka, Kazuo Yamamoto, Takeshi Horaguchi, Masahiro Fukada, Yuki Sengoku, Itaru Yasufuku, Ryuichi Asai, Jesse Yu Tajima, Shigeru Kiyama, Takazumi Kato, Katsutoshi Murase, Nobuhisa Matsuhashi
BACKGROUND: Esophageal squamous cell carcinoma is characterized by field cancerization, wherein multiple cancers occur in the esophagus, head and neck, and stomach. Synchronous esophageal and colorectal cancers are also encountered with a certain frequency. A good prognosis can be expected if the tumors in both locations can be safely and completely removed. For patients with multiple cancers that occur simultaneously with esophageal cancer, it is necessary to perform a staged operation, taking into consideration the associated surgical invasiveness...
March 14, 2024: World Journal of Surgical Oncology
https://read.qxmd.com/read/38484586/recent-development-of-vegfr-small-molecule-inhibitors-as-anticancer-agents-a-patent-review-2021-2023
#3
REVIEW
Jing Zeng, Qichuan Deng, Zheng Chen, Shuang Yan, Qin Dong, Yuyu Zhang, Yuan Cui, Ling Li, Yuxin He, Jianyou Shi
VEGFR, a receptor tyrosine kinase inhibitor (TKI), is an important regulatory factor that promotes angiogenesis and vascular permeability. It plays a significant role in processes such as tumor angiogenesis, tumor cell invasion, and metastasis. VEGFR is mainly composed of three subtypes: VEGFR-1, VEGFR-2, and VEGFR-3. Among them, VEGFR-2 is the crucial signaling receptor for VEGF, which is involved in various pathological and physiological functions. At present, VEGFR-2 is closely related to a variety of cancers, such as non-small cell lung cancer (NSCLC), Hepatocellular carcinoma, Renal cell carcinoma, breast cancer, gastric cancer, glioma, etc...
March 9, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38483129/gastric-metastasis-from-breast-cancer-five-cases-and-a-single-institutional-review
#4
JOURNAL ARTICLE
Meng Cheng, Zhanli Jia, Guoyu Zhang, Yingnan Wang, Sainan Li, Shan Yang, Chunxiao Li, Cuizhi Geng
Gastric metastasis from breast cancer has a high rate of misdiagnosis and missed diagnosis. Data of patients who had gastric metastasis from breast cancer were retrieved from our hospital between 2014 and 2020. The gastric metastasis from breast cancer incidence was 0.04% (5/14,169 cases of breast cancer). Four patients had invasive lobular carcinoma, and the other patient had invasive ductal carcinoma. The time from the initial diagnosis of breast cancer to the appearance of gastric metastasis ranged from 0 to 12 years...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38482443/comprehensive-analysis-of-the-effects-of-the-cuprotosis-associated-gene-slc31a1-on-patient-prognosis-and-tumor-microenvironment-in-human-cancer
#5
JOURNAL ARTICLE
Guiqian Zhang, Ning Wang, Shixun Ma, Pengxian Tao, Hui Cai
BACKGROUND: Solute carrier family 31 (copper transporter), member 1 ( SLC31A1 ) is a key factor in maintaining intracellular copper concentration and an important factor affecting cancer energy metabolism. Therefore, exploring the potential biological function and value of SLC31A1 could provide a new direction for the targeted therapy of tumors. METHODS: This study assessed gene expression levels, survival, clinicopathology, gene mutations, methylation levels, the tumor mutational burden (TMB), microsatellite instability (MSI), and the immune cell infiltration of SLC31A1 in pan-cancer using the Tumor Immune Estimation Resource 2...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38480051/prognostic-factors-in-clinicopathology-of-oesophagogastric-adenocarcinoma-a-single-centre-longitudinal-study-of-347-cases-over-a-20-year-period
#6
JOURNAL ARTICLE
Qin Huang, Edward Lew, Yuqing Cheng, Kevin Huang, Vikram Deshpande, Shweta Shinagare, Xin Yuan, Jason S Gold, Daniel Wiener, H Christian Weber
Oesophagogastric adenocarcinoma (EGA) includes oesophageal (EA), gastro-oesophageal junctional (GEJA), and gastric (GA) adenocarcinomas. The prognostic values of clinicopathological factors in these tumours remain obscure, especially for GEJA that has been inconsistently classified and staged. We studied the prognosis of EGA patients among the three geographic groups in 347 consecutive patients with a median age of 70 years (range 47-94). All patients were male, and 97.1% were white. Based on tumour epicentre location, EGAs were sub-grouped into EA (over 2 cm above the GEJ; n=3, 18...
February 27, 2024: Pathology
https://read.qxmd.com/read/38474415/building-a-better-defense-expanding-and-improving-natural-killer-cells-for-adoptive-cell-therapy
#7
REVIEW
Andreia Maia, Mubin Tarannum, Joana R Lérias, Sara Piccinelli, Luis Miguel Borrego, Markus Maeurer, Rizwan Romee, Mireia Castillo-Martin
Natural killer (NK) cells have gained attention as a promising adoptive cell therapy platform for their potential to improve cancer treatments. NK cells offer distinct advantages over T-cells, including major histocompatibility complex class I (MHC-I)-independent tumor recognition and low risk of toxicity, even in an allogeneic setting. Despite this tremendous potential, challenges persist, such as limited in vivo persistence, reduced tumor infiltration, and low absolute NK cell numbers. This review outlines several strategies aiming to overcome these challenges...
March 5, 2024: Cells
https://read.qxmd.com/read/38469021/gastric-adenocarcinoma-with-unusual-clear-tubulopapillary-morphology-a-case-report
#8
Nadir Miry, Younesse Najioui, Anass Haloui, Nassira Karich, Amal Bennani
Gastric clear cell adenocarcinoma is an extremely rare variant of papillary adenocarcinoma of the stomach. It is associated with a poor prognosis due to its frequent lymphovascular invasion and also its higher risk of recurrence. It is characterized morphologically by a clear appearance of tumor cells, which can be easily confused with a metastasis of a clear cell carcinoma, particularly of renal origin. Very few cases have been previously reported in the literature, which makes it a very poorly known variant...
February 2024: Curēus
https://read.qxmd.com/read/38464547/prognostic-impact-of-thrombocytosis-in-gastric-cancer-a-retrospective-study
#9
JOURNAL ARTICLE
Bárbara Neto Castro, Catarina Costa, Daniel Martins, Andreia Amado, Mariana Santos, Susana Graça, Amélia Tavares, António Ferreira, Fernando Viveiros, Sílvio Vale, Manuel Oliveira
BACKGROUND: Solid tumors are a common cause of secondary thrombocytosis, which has been identified as a prognostic factor in various cancers. However, the impact of thrombocytosis on the prognosis of gastric cancer is not yet well defined. The aim of this study was to assess the prevalence and prognostic value of thrombocytosis in patients with gastric cancer. METHODS: This was a retrospective study of patients with gastric carcinoma treated surgically, with curative intent, in our hospital, Centro Hospitalar Vila Nova de Gaia/Espinho, between January 2009 and December 2019...
2024: Porto Biomedical Journal
https://read.qxmd.com/read/38462175/regulation-mechanism-of-ebv-encoded-eber1-and-lmp2a-on-yap1-and-the-impact-of-yap1-on-the-ebv-infection-status-in-ebv-associated-gastric-carcinoma
#10
JOURNAL ARTICLE
Yujie Sun, Duo Shi, Jiting Sun, Yan Zhang, Wen Liu, Bing Luo
This study aims to explore the role and regulatory mechanism of Yes-associated protein 1 (YAP1) in the development of Epstein-Barr virus-associated gastric cancer (EBVaGC). Here we showed that EBV can upregulate the expression and activity of YAP1 protein through its encoded latent products EBV-encoded small RNA 1 (EBER1) and latent membrane protein 2A (LMP2A), enhancing the malignant characteristics of EBVaGC cells. In addition, we also showed that overexpression of YAP1 induced the expression of EBV encoding latent and lytic phase genes and proteins in the epithelial cell line AGS-EBV infected with EBV, and increased the copy number of the EBV genome, while loss of YAP1 expression reduced the aforementioned indicators...
March 11, 2024: Virus Research
https://read.qxmd.com/read/38462149/multi-disciplinary-management-of-esophageal-carcinoma-current-practices-and-future-directions
#11
REVIEW
Chanyoot Bandidwattanawong
Esophageal cancer in one of the most malignant and hard-to-treat cancers. Esophageal squamous carcinoma (ESCC) is most common in Asian countries, whereas adenocarcinoma at the esophago-gastric junction (EGJ AC) is more prevalent in the Western countries. Due to differences in both genetic background and response to chemotherapy and radiotherapy, both histologic subtypes need different paradigms of management. Since the landmark CROSS study has demonstrated the superior survival benefit of tri-modality including neoadjuvant chemoradiotherapy prior to esophagectomy, the tri-modality becomes the standard of care; however, it is suitable for a highly-selected patient...
March 8, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38459566/the-spectrum-of-tp53-mutations-in-rwandan-patients-with-gastric-cancer
#12
JOURNAL ARTICLE
Augustin Nzitakera, Jean Bosco Surwumwe, Ella Larissa Ndoricyimpaye, Schifra Uwamungu, Delphine Uwamariya, Felix Manirakiza, Marie Claire Ndayisaba, Gervais Ntakirutimana, Benoit Seminega, Vincent Dusabejambo, Eric Rutaganda, Placide Kamali, François Ngabonziza, Rei Ishikawa, Belson Rugwizangonga, Yuji Iwashita, Hidetaka Yamada, Kimio Yoshimura, Haruhiko Sugimura, Kazuya Shinmura
BACKGROUND: Gastric cancer is the sixth most frequently diagnosed cancer and third in causing cancer-related death globally. The most frequently mutated gene in human cancers is TP53, which plays a pivotal role in cancer initiation and progression. In Africa, particularly in Rwanda, data on TP53 mutations are lacking. Therefore, this study intended to obtain TP53 mutation status in Rwandan patients with gastric cancer. RESULTS: Formalin-fixed paraffin-embedded tissue blocks of 95 Rwandan patients with histopathologically proven gastric carcinoma were obtained from the University Teaching Hospital of Kigali...
March 8, 2024: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://read.qxmd.com/read/38458911/prognostic-significance-of-serum-tumor-markers-in-various-pathologic-subtypes-of-gastric-cancer
#13
JOURNAL ARTICLE
Chuhong Pang, Yubo Ma, Wenyi Shi, Mengli Zi, Jinxia Chen, Chen Liang, Xiao Li, Zhuo Liu, Yian Du
PURPOSE: This study aimed to assess the utility of 6 serum tumor markers in prognosis between gastric adenocarcinoma and gastric signet ring cell carcinoma (SRCC). METHODS: A cohort of 3131 cases of gastric adenocarcinoma and 275 cases of gastric SRCC was assembled. The serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 125, alpha fetoprotein (AFP), carbohydrate antigen 242 (CA242), and carbohydrate antigen 724 (CA724) were measured in all cases...
February 20, 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38457192/clinicopathological-characteristics-of-gastric-neuroendocrine-neoplasms-a-comprehensive-analysis
#14
JOURNAL ARTICLE
Mengli Zi, Yubo Ma, Jinxia Chen, Chuhong Pang, Xiao Li, Li Yuan, Zhuo Liu, Pengfei Yu
OBJECTIVE: This study aimed to explore the clinicopathological characteristics and prognostic implications of gastric neuroendocrine neoplasms (g-NENs). METHODS: A retrospective enrollment of 142 patients diagnosed with g-NENs was conducted at Zhejiang Cancer Hospital between January 1, 2007 and December 31, 2021. The study compared essential clinicopathological features and survival rates. Additionally, the prognosis of gastric neuroendocrine carcinomas/mixed neuroendocrine-non-neuroendocrine neoplasms (g-NEC/MiNEN) were contrasted with those of gastric adenocarcinoma (GAC) and signet ring cell carcinoma (SRCC)...
February 2024: Cancer Medicine
https://read.qxmd.com/read/38455368/genomic-characterization-of-peritoneal-lavage-cytology-positive-gastric-cancer
#15
JOURNAL ARTICLE
Zhouqiao Wu, Tingfei Gu, Changxian Xiong, Jinyao Shi, Jingpu Wang, Ting Guo, Xiaofang Xing, Fei Pang, Ning He, Rulin Miao, Fei Shan, Yuan Zhou, Ziyu Li, Jiafu Ji
OBJECTIVE: Positive peritoneal lavege cytology (CY1) gastric cancer is featured by dismal prognosis, with high risks of peritoneal metastasis. However, there is a lack of evidence on pathogenic mechanism and signature of CY1 and there is a continuous debate on CY1 therapy. Therefore, exploring the mechanism of CY1 is crucial for treatment strategies and targets for CY1 gastric cancer. METHODS: In order to figure out specific driver genes and marker genes of CY1 gastric cancer, and ultimately offer clues for potential marker and risk assessment of CY1, 17 cytology-positive gastric cancer patients and 31 matched cytology-negative gastric cancer patients were enrolled in this study...
February 29, 2024: Chinese Journal of Cancer Research
https://read.qxmd.com/read/38455367/molecular-features-of-gastroenteropancreatic-neuroendocrine-carcinoma-a-comparative-analysis-with-lung-neuroendocrine-carcinoma-and-digestive-adenocarcinomas
#16
JOURNAL ARTICLE
Jianwei Zhang, Hanxiao Chen, Junli Zhang, Sha Wang, Yanfang Guan, Wenguang Gu, Jie Li, Xiaotian Zhang, Jian Li, Xicheng Wang, Zhihao Lu, Jun Zhou, Zhi Peng, Yu Sun, Yang Shao, Lin Shen, Minglei Zhuo, Ming Lu
OBJECTIVE: There is an ongoing debate about whether the management of gastroenteropancreatic (GEP) neuroendocrine carcinoma (NEC) should follow the guidelines of small-cell lung cancer (SCLC). We aim to identify the genetic differences of GEPNEC and its counterpart. METHODS: We recruited GEPNEC patients as the main cohort, with lung NEC and digestive adenocarcinomas as comparative cohorts. All patients undergone next-generation sequencing (NGS). Different gene alterations were compared and analyzed between GEPNEC and lung NEC (LNEC), GEPNEC and adenocarcinoma to yield the remarkable genes...
February 29, 2024: Chinese Journal of Cancer Research
https://read.qxmd.com/read/38454538/a-genome-wide-study-of-gastric-intramucosal-neoplasia-based-on-somatic-copy-number-alterations-gene-mutations-and-mrna-expression-patterns
#17
JOURNAL ARTICLE
Yoshihiko Koike, Mitsumasa Osakabe, Ryo Sugimoto, Noriyuku Uesugi, Takayuki Matsumoto, Hiromu Suzuki, Naoki Yanagawa, Tamotsu Sugai
We performed comprehensive analyses of somatic copy number alterations (SCNAs) and gene expression profiles of gastric intramucosal neoplasia (IMN) using array-based methods in 97 intestinal-type IMNs, including 39 low-grade dysplasias (LGDs), 37 high-grade dysplasias (HGDs), and 26 intramucosal carcinomas (IMCs) with stromal invasion of the lamina propria to identify the molecular mechanism of IMN. In addition, we examined gene mutations using gene panel analyses. We used cluster analyses for exclusion of arbitrariness to identify SCNA patterns and expression profiles...
March 2024: Journal of Pathology. Clinical Research
https://read.qxmd.com/read/38452587/harnessing-the-supremacy-of-meg3-lncrna-to-defeat-gastrointestinal-malignancies
#18
REVIEW
H H Rashwan, A M Taher, H A Hassan, A A Awaji, C J Kiriacos, R A Assal, R A Youness
Evidence suggests that long non-coding RNAs (lncRNAs) play a pivotal role in the carcinogenesis and progression of various human malignancies including gastrointestinal malignancies. This comprehensive review reports the functions and mechanisms of the lncRNA maternally expressed gene 3 (MEG3) involved in gastrointestinal malignancies. It summarizes its roles in mediating the regulation of cellular proliferation, apoptosis, migration, invasiveness, epithelial-to-mesenchymal transition, and drug resistance in several gastrointestinal cancers such as colorectal cancer, gall bladder cancer, pancreatic cancer, gastric cancer, esophageal cancer, cholangiocarcinoma, gastrointestinal stromal tumors and most importantly, hepatocellular carcinoma...
February 23, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38452580/cadherin-17-cdh17-expression-in-human-cancer-a-tissue-microarray-study-on-18-131-tumors
#19
JOURNAL ARTICLE
Frank Jacobsen, Ramesh Pushpadevan, Florian Viehweger, Morton Freytag, Ria Schlichter, Natalia Gorbokon, Franziska Büscheck, Andreas M Luebke, Devita Putri, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Christoph Fraune, Christian Bernreuther, Patrick Lebok, Guido Sauter, Sarah Minner, Stefan Steurer, Ronald Simon, Eike Burandt, David Dum, Florian Lutz, Andreas H Marx, Till Krech, Till S Clauditz
Cadherin-17 (CDH17) is a membranous cell adhesion protein predominantly expressed in intestinal epithelial cells. CDH17 is therefore considered a possible diagnostic and therapeutic target. This study was to comprehensively determine the expression of CDH17 in cancer and to further assess the diagnostic utility of CDH17 immunohistochemistry (IHC). A tissue microarray containing 14,948 interpretable samples from 150 different tumor types and subtypes as well as 76 different normal tissue types was analyzed by IHC...
January 28, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38452473/molecular-insights-into-gastric-cancer-the-impact-of-tgfbr2-and-hsa-mir-107-revealed-by-microarray-sequencing-and-bioinformatics
#20
JOURNAL ARTICLE
Zhengsen Jin, Zhihong Huang, Chao Wu, Fanqin Zhang, Yifei Gao, Siyu Guo, Xiaoyu Tao, Shan Lu, Jingyuan Zhang, Jiaqi Huang, Yiyan Zhai, Rui Shi, Peizhi Ye, Jiarui Wu
BACKGROUND: Gastric carcinoma (GC) remains a significant therapeutic challenge, garnering widespread attention. Oxymatrine (OMT), an active component of the traditional Chinese medicine compound Kushen injection (CKI), has shown promising results in combination with chemotherapy for the treatment of GC. However, the molecular mechanisms underlying OMT's therapeutic effects in GC have yet to be elucidated. METHODS: The transcriptomic expression data of HGC-27 post-OMT intervention were obtained through microarray sequencing, while the miRNA and mRNA sequencing data for GC patients were sourced from the TCGA database...
March 2, 2024: Computers in Biology and Medicine
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