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https://www.readbyqxmd.com/read/28635220/-the-bisphenol-a-enhanced-activity-of-thyroid-carcinoma-cell-line-b-cpap-is-inhibited-by-icarrin
#1
C M Zheng, X Z Liu, Q L Li, J F Wang, Z Tan, M H Ge
Objective: To investigate the effect of icariin (ICA) on the bisphenol A (BPA)-enhanced proliferation function of thyroid carcinoma cell B-CPAP and underlying mechanism. Methods: The proliferation of Gastric B-CPAP cell line was evaluated by cell counting kit-8 (CCK-8). Apoptosis and ROS expression in B-CPAP cells were detected by flow cytometry. The expression of superoxide dismutase (SOD) and malondialdehyde (MDA) in B-CPAP cells were measured by individual assay kits. The expressions of Bcl-2 and γ-HA2X were detected by Western blot...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28632135/evaluation-of-the-branched-chain-amino-acid-to-tyrosine-ratio-prior-to-treatment-as-a-prognostic-predictor-in-patients-with-liver-cirrhosis
#2
Toru Ishikawa, Michitaka Imai, Masayoshi Ko, Hiroki Sato, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Toshiaki Yoshida
This study evaluated whether the branched-chain amino acid-to-tyrosine ratio (BTR) is a prognostic predictive factor in patients with liver cirrhosis by determining the relationship of the BTR with event-free survival in a retrospective, observational cohort study. The medical records of patients with liver cirrhosis who visited our institution from February 2000 to May 2012 were examined. Events due to liver cirrhosis were defined as death, worsening of esophageal and/or gastric varices, hepatocellular carcinoma, and liver failure...
June 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28631563/prognostic-significance-of-glutathione-peroxidase-2-in-gastric-carcinoma
#3
Dongzhe Liu, Liang Sun, Jinxue Tong, Xiuhui Chen, Hui Li, Qifan Zhang
Increasing evidence suggests that the glutathione peroxidase 2 may actually play important roles in tumorigenesis and progression in various human cancers such as colorectal carcinomas and lung adenocarcinomas. However, the role of glutathione peroxidase 2 in gastric carcinoma remains to be determined. In this study, the expression and prognostic significance of glutathione peroxidase 2 in gastric carcinoma were investigated and the well-known prognostic factor Ki-67 labeling index was also assessed as positive control...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28631148/early-postoperative-imaging-after-non-bariatric-gastric-resection-a-primer-for-radiologists
#4
REVIEW
Massimo Tonolini, Elena Bracchi
Surgical resection represents the mainstay treatment and only potentially curative option for gastric carcinoma, and is increasingly performed laparoscopically. Furthermore, other tumours and selected cases of non-malignant disorders of the stomach may require partial or total gastrectomy. Often performed in elderly patients, gastric resection remains a challenging procedure, with significant morbidity (14-43% complication rate) and non-negligible postoperative mortality (approximately 3%). This paper provides an overview of contemporary surgical techniques for non-bariatric gastric resection, reviews and illustrates the expected postoperative imaging appearances, common and unusual complications after partial and total gastrectomy...
June 19, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28628924/chrysin-alters-micrornas-expression-levels-in-gastric-cancer-cells-possible-molecular-mechanism
#5
Farideh Mohammadian, Younes Pilehvar-Soltanahmadi, Shahriar Alipour, Mehdi Dadashpour, Nosratollah Zarghami
Background Gastric carcinoma still remains the second most common cause of cancer mortality in the world. Chrysin, as a flavone, has showed cancer chemopreventive activity. The cellular and molecular mechanisms of chrysin in cancer cells have not been fully understood. Objective In this study, we investigate expression levels of let-7a, miR-9, mir-18a, miR-21, miR-22, miR-34a, miR-126 and mir-221 to describe the anti-cancer effects of chrysin. Materials and Methods The cytotoxic effects of chrysin were assessed using MTT assay...
June 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28625415/gastric-metastatic-extension-of-invasive-ductal-carcinoma-of-the-breast-with-atypical-endoscopic-presentation
#6
Claudia de Zárraga Mata, Guiem Thomas Salom, Angels Vilella Martorell, Francisca Salvà Ramonell, Ángela Laura Maura Oliver, Carlos Dolz Abadía
No abstract text is available yet for this article.
June 15, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28625333/liver-metastases-from-gastric-carcinoma-a-case-report-and-review-of-the-literature
#7
Beata Polkowska-Pruszyńska, Karol Rawicz-Pruszyński, Bogumiła Ciseł, Robert Sitarz, Grażyna Polkowska, Witold Krupski, Wojciech P Polkowski
Gastric carcinoma (GC) is the fifth most common malignancy worldwide but the third leading cause of cancer death, and surgery remains the only curative treatment option. Prognosis of patients with liver metastases from gastric carcinoma (LMGC) is poor, and the optimal treatment of metastatic gastric cancer remains a matter of debate. In 2002, a 53-year-old male patient with GC and synchronous oligometastatic lesion in liver VIII segment underwent a total gastrectomy combined with metastasectomy. The pathologic diagnosis was stage IV gastric adenocarcinoma (pT3N2M1), which was treated with adjuvant chemotherapy (cisplatin, epirubicin, leucovorin, and 5-fluorouracil)...
May 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/28625066/a-rectal-neuroendocrine-neoplasm
#8
Modesto J Varas Lorenzo, Fernando Muñoz Agel
The incidence of gastric and rectal carcinoids is increasing. This is probably due to endoscopic screening. The prognosis is primarily dependent upon tumor size, aggressiveness (pathology, Ki-67), metastatic disease and stage. However, neuroendocrine carcinoma usually behaves as an adenocarcinoma.
June 19, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28625044/her2-status-and-its-heterogeneity-in-gastric-carcinoma-of-vietnamese-patients
#9
Dang Anh Thu Phan, Vu Thien Nguyen, Thi Ngoc Ha Hua, Quoc Dat Ngo, Thi Phuong Thao Doan, Sao Trung Nguyen, Anh Tu Thai, Van Thanh Nguyen
Background: Human epidermal growth factor receptor 2 (HER2) is related to the pathogenesis and poor outcome of numerous types of carcinomas, including gastric carcinoma. Gastric cancer patients with HER2 positivity have become potential candidates for targeted therapy with trastuzumab. Materials and Methods: We investigated 208 gastric cancer specimens using immunohistochemistry (IHC), fluorescence in situ hybridization and dual in situ hybridization (ISH). We also investigated the concordance between IHC and ISH...
June 19, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28623738/iridoids-from-the-roots-of-valeriana-jatamansi-jones
#10
Ru-Jing Wang, Hai-Mei Chen, Fan Yang, Yun Deng, Hui Ao, Xiao-Fang Xie, Hong-Xiang Li, Hai Zhang, Zhi-Xing Cao, Li-Xia Zhu, Yin Chen, Cheng Peng, Yu-Zhu Tan
Five iridoids, named as chlorovaltrate P-T, together with six known analogues, (4β,8β)-8-methoxy-3-methoxy-10-methylene-2,9-dioxatricyclo[4.3.1.0(3,7)]decan-4-ol, chlorovaltrate A, (1R,3R,5R,7S,8R,9S)-3,8-epoxy-1-O-ethyl-5-hydroxyvalechlorine, 8-methoxy-4-acetoxy-3-chlormethyl-10-methylen-2,9-dioxa-tricyclo[4.3.1.0(3,7)]decan, (1S,3R,5R,7S,8R,9S)-3,8-epoxy-1-O-ethyl-5-hydroxyvalechlorine, (1R,3R,5R,7S,8R,9S)-3,8-epoxy-1-O-methyl-5-hydroxyvalechlorine were isolated from the roots of Valeriana jatamansi (syn...
June 14, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28621235/mmp-2-together-with-mmp-9-overexpression-correlated-with-lymph-node-metastasis-and-poor-prognosis-in-early-gastric-carcinoma
#11
Zhihua Yao, Tian Yuan, Haiying Wang, Shuna Yao, Yan Zhao, Ying Liu, Shuiling Jin, Junfeng Chu, Yuanlin Xu, Wenping Zhou, Shujun Yang, Yanyan Liu
The aim of this study was to correlate matrix metalloproteinase-2 and matrix metalloproteinase-9 expression with the clinicopathological features and outcome of patients with early gastric cancer and to clinically elucidate more information on the role of matrix metalloproteinase-2 and matrix metalloproteinase-9 protein overexpression with regard to lymph node metastasis of early gastric cancer. The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 protein expression were assessed by immunohistochemistry...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28619681/gastric-carcinoma-after-sleeve-gastrectomy-for-obesity
#12
Miljana Vladimirov, Uwe Hesse, Hubert J Stein
Obesity is associated with an increased risk of cancer development in the upper gastrointestinal tract. We present the case of a female patient with gastric carcinoma after sleeve gastrectomy. Before bariatric surgery, one rationale for performing routine endoscopy is to detect clinically relevant conditions with the potential to change the surgical procedure. After bariatric surgery in symptomatic patients and in patients with unspecific symptoms, early upper endoscopy should be performed to detect potential carcinomas of the upper gastrointestinal tract...
April 25, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28618943/long-non-coding-rna-dancr-a-prognostic-indicator-promotes-cell-growth-and-tumorigenicity-in-gastric-cancer
#13
Yan-Ping Hao, Jing-Hui Qiu, Dong-Bo Zhang, Cheng-Gong Yu
Gastric cancer remains the third leading cause of cancer-related mortality worldwide, and proliferation of gastric cancer represents the major reason for its poor prognosis. Recent evidence indicates that long non-coding RNAs play crucial roles in development and progression of gastric cancer. Long non-coding RNA differentiation antagonizing non-protein coding RNA is upregulated in hepatic cell carcinoma, but the role of lncRNA differentiation antagonizing non-protein coding RNA in gastric cancer has not been explored...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28618942/prognostic-role-of-fibroblast-growth-factor-receptor-2-in-human-solid-tumors-a-systematic-review-and-meta-analysis
#14
REVIEW
Gang Liu, Disheng Xiong, Rui Xiao, Zhengjie Huang
In the past decades, the oncogenic role of fibroblast growth factor receptor 2 has been demonstrated in a number of cancer types. However, studies have reported contradictory findings concerning the correlation between fibroblast growth factor receptor 2 expression and prognosis in solid tumors. To address this discrepancy, we performed a meta-analysis with 18 published studies (2975 patients) retrieved from PubMed, EMBASE, and Web of science. Data were extracted and computed into odds ratios. The results showed that fibroblast growth factor receptor 2 overexpression was significantly associated with decreased 3-year overall survival (odds ratio = 1...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28617917/genomic-profiling-of-small-bowel-adenocarcinoma
#15
Alexa B Schrock, Craig E Devoe, Robert McWilliams, James Sun, Thomas Aparicio, Philip J Stephens, Jeffrey S Ross, Richard Wilson, Vincent A Miller, Siraj M Ali, Michael J Overman
Importance: Small-bowel adenocarcinomas (SBAs) are rare cancers with a significantly lower incidence, later stage at diagnosis, and worse overall survival than other intestinal-derived cancers. To date, comprehensive genomic analysis of SBA is lacking. Objective: To perform in-depth genomic characterization of a large series of SBAs and other gastrointestinal tumors to draw comparisons and identify potentially clinically actionable alterations. Design, Setting, and Participants: Prospective analysis was performed of clinical samples from patients with SBA (n = 317), colorectal cancer (n = 6353), and gastric carcinoma (n = 889) collected between August 24, 2012, and February 3, 2016, using hybrid-capture-based genomic profiling, at the request of the individual treating physicians in the course of clinical care for the purpose of making therapy decisions...
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28617871/hypoxia-inducible-factor-1%C3%AE-plays-roles-in-epstein-barr-virus-s-natural-life-cycle-and-tumorigenesis-by-inducing-lytic-infection-through-direct-binding-to-the-immediate-early-bzlf1-gene-promoter
#16
Richard J Kraus, Xianming Yu, Blue-Leaf A Cordes, Saraniya Sathiamoorthi, Tawin Iempridee, Dhananjay M Nawandar, Shidong Ma, James C Romero-Masters, Kyle G McChesney, Zhen Lin, Kathleen R Makielski, Denis L Lee, Paul F Lambert, Eric C Johannsen, Shannon C Kenney, Janet E Mertz
When confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible factor alphas (HIF-αs). We report here that HIF-1α also regulates the life cycle of Epstein-Barr virus (EBV). Incubation of EBV-positive gastric carcinoma AGS-Akata and SNU-719 and Burkitt lymphoma Sal and KemIII cell lines with a prolyl hydroxylase inhibitor, L-mimosine or deferoxamine, or the NEDDylation inhibitor MLN4924 promoted rapid and sustained accumulation of both HIF-1α and lytic EBV antigens...
June 15, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28615102/-effect-of-golgi-%C3%AE-mannosidase-2-gm2-gene-knockdown-on-adhesion-abilities-of-human-gastric-carcinoma-cell-line-bgc-823-and-its-mechanism
#17
Bo Zeng, Zhen Zeng, Chang Liu, Yaying Yang
Objective To investigate the effect of Golgi α-mannosidase II (GM2) gene knockdown on adhesion abilities of BGC-823 human gastric carcinoma cells. Methods Three plasmid vectors expressing GM2 shRNAs and a negative control plasmid vector were designed, constructed and then transfected into BGC-823 cells by Lipofectamine(TM) 2000. After transfection, the mRNA and protein levels of GM2 in BGC-823 cells were detected by real-time quantitative PCR (qRT-PCR) and Western blotting to evaluate the transfection efficacy...
June 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28612195/human-epidermal-growth-factor-receptor-2-in-sri-lankan-gastric-carcinoma-patients-with-clinicopathological-association-and-survival
#18
Duminda Subasinghe, Sivasuriya Sivaganesh, Ananthi Samarsekera, Mariyan Priyanthi Kumarasinghe, Dharmabandhu Nandadeva Samarasekera, Menaka Dilani Samarwickrema Lokuhetty
BACKGROUND: HER2 protein expression indicates adverse prognosis in gastric adenocarcinoma (GCa). GCa HER2 positivity ranges from 10 to 22.8%. Similar data are scarce in South Asia and unavailable in Sri Lanka. AIM: To evaluate HER2 protein expression, its clinicopathological relationship and survival in a Sri Lankan GCa cohort. METHODS: One hundred consecutive GCa patients were recruited prospectively for 2 years. Histological diagnosis was confirmed on endoscopic biopsies/gastrectomy specimens...
June 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28611977/clinicopathology-of-early-gastric-carcinoma-an-update-for-pathologists-and-gastroenterologists
#19
REVIEW
Qin Huang, Xiaoping Zou
BACKGROUND: The WHO defines early gastric carcinoma (EGC) as invasive carcinoma up to the submucosal layer, regardless of nodal metastasis. The recent study results indicate that EGC varies in location, histology, nodal metastasis, and prognosis. SUMMARY: The heterogeneity in EGC may be related to various types of epithelial stem cells. The most important stem cells include Lgr5(+) cells at the base of a gastric unit in the antrum-pylorus-cardia, Mist1(+) cells at the isthmus/Troy(+) cells at the base in the corpus-fundus, and Sox2(+) cells at the base in almost all regions...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28611525/clinical-significance-of-expression-of-proliferating-cell-nuclear-antigen-and-e-cadherin-in-gastric-carcinoma
#20
Lin Hu, Hong-Lang Li, Wei-Feng Li, Jun-Min Chen, Jian-Tao Yang, Jun-Jing Gu, Lin Xin
AIM: to investigate the expression of proliferating cell nuclear antigen (PCNA) and E-cadherin in gastric carcinoma and to analyze their clinical significance. METHODS: A total of 146 patients were selected for this study, including 38 patients with intestinal metaplasia, 42 with dysplasia, and 66 with primary gastric cancer. In addition, 40 patients with normal gastric tissues were selected as controls. The expression of PCNA and E-cadherin was detected by immunohistochemistry...
May 28, 2017: World Journal of Gastroenterology: WJG
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