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https://www.readbyqxmd.com/read/29232640/decomposition-of-ibuprofen-in-water-via-an-electrochemical-process-with-nano-sized-carbon-black-coated-carbon-cloth-as-oxygen-permeable-cathode-integrated-with-ultrasound
#1
Reza Darvishi Cheshmeh Soltani, Masumeh Mashayekhi
The main aim of the present investigation was the treatment of ibuprofen (IBP)-polluted aquatic phase using a novel oxygen-permeable cathode (OPC)-equipped electrochemical process (ECP) integrated with ultrasound (US). According to kinetic modeling, the decomposition rate of IBP by the integrated process was 3.2 × 10-2 min-1 which was significant in comparison with the OPC-equipped ECP (1.4 × 10-2 min-1) and US alone (2.4 × 10-3 min-1). Increasing the current resulted in the enhanced generation of H2O2 and consequently, improved the degradation of IBP in the solution...
December 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29232602/cooperative-protein-unfolding-a-statistical-mechanical-model-for-the-action-of-denaturants
#2
J Seelig
Knowledge of protein stability is of utmost importance in various fields of biotechnology. Protein stability can be assessed in solution by increasing the concentration of denaturant and recording the structural changes with spectroscopic or thermodynamic methods. The standard interpretation of the experimental data is to assume a 2-state equilibrium between completely folded and completely unfolded protein molecules. Here we propose a cooperative model based on the statistical-mechanical Zimm-Bragg theory...
December 5, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/29232519/using-density-based-indexes-and-wavefunction-methods-for-the-description-of-excited-states-excited-state-proton-transfer-reactions-as-test-case
#3
Juan Sanz García, Federica Maschietto, Marco Campetella, Ilaria Ciofini
To provide tools to interpret photochemical reactions, in this paper we demonstrate how a recently developed density-based index (DCT), up to now used in conjunction with Time Dependent Density Functional Theory methods, can be extended to multi-configurational methods. This index can guide chemists in the interpretation of photochemical reactions providing a measure of the spatial extent of a photo-induced charge transfer and, more generally, of charge transfer phenomena. This qualitative and quantitative description can be particularly relevant in the case of multi-configurational calculations providing a simple tool for the interpretation of their complex outputs...
December 12, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29232475/front-line-therapy-of-advanced-ovarian-cancer-new-approaches
#4
J A Ledermann
Background: The 5-year survival of ovarian cancer has slowly increased but to date much of this has been due to the use of more lines of treatment rather than better first-line therapy. In this setting, there has been little improvement over the past 15 years. The introduction of new treatments to extend time to first progression and overall survival remains a key objective of clinical research. Design: The focus of research in the previous decade has been on the incorporation of anti-angiogenic therapy or dose-dense scheduling of paclitaxel (Taxol) to improve outcome...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29232474/is-intraperitoneal-chemotherapy-still-an-acceptable-option-in-primary-adjuvant-chemotherapy-for-advanced-ovarian-cancer
#5
B J Monk, J K Chan
The role of intraperitoneal (i.p.) chemotherapy in treating newly diagnosed advanced epithelial ovarian cancer (EOC) has been the subject of controversy for almost three decades. Three large intergroup phase III trials (GOG 104, 114, 172) have demonstrated a survival benefit associated with i.p. over intravenous (i.v.) therapy in advanced, low-volume EOC. Despite the positive clinical trial results and a subsequent National Cancer Institute alert in 2006, i.p. treatment has not been widely accepted as the standard of care in the United States and is infrequently used in Europe...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29232403/genomics-clarifies-taxonomic-boundaries-in-a-difficult-species-complex
#6
Jason Baumsteiger, Peter B Moyle, Andres Aguilar, Sean M O'Rourke, Michael R Miller
Efforts to taxonomically delineate species are often confounded with conflicting information and subjective interpretation. Advances in genomic methods have resulted in a new approach to taxonomic identification that stands to greatly reduce much of this conflict. This approach is ideal for species complexes, where divergence times are recent (evolutionarily) and lineages less well defined. The California Roach/Hitch fish species complex is an excellent example, experiencing a convoluted geologic history, diverse habitats, conflicting species designations and potential admixture between species...
2017: PloS One
https://www.readbyqxmd.com/read/29232387/improved-sample-treatment-protocol-for-accurate-detection-of-live-salmonella-spp-in-food-samples-by-viability-pcr
#7
Mai Dinh Thanh, Gemma Agustí, Anneluise Mader, Bernd Appel, Francesc Codony
Culture-based detection is still considered as the standard way for detection of Salmonella in foods, although molecular methods, such as viability PCR (vPCR), have been introduced to overcome some disadvantages of traditional culture methods. Despite the success of the vPCR methodology, the problem of false-positive results is a major drawback, especially when applied to environmental samples, hindering the interpretation of the results. To improve the efficiency of vPCR, many approaches have been introduced by several authors during the last years...
2017: PloS One
https://www.readbyqxmd.com/read/29232365/monitoring-compliance-with-standards-of-care-for-chronic-diseases-using-healthcare-administrative-databases-in-italy-strengths-and-limitations
#8
Rosa Gini, Martijn J Schuemie, Alessandro Pasqua, Emanuele Carlini, Francesco Profili, Iacopo Cricelli, Patrizio Dazzi, Valentina Barletta, Paolo Francesconi, Francesco Lapi, Andrea Donatini, Giulia Dal Co, Modesta Visca, Mariadonata Bellentani, Miriam Sturkenboom, Niek Klazinga
BACKGROUND: A recent comprehensive report on healthcare quality in Italy published by the Organization of Economic Co-operation and Development (OECD) recommended that regular monitoring of quality of primary care by means of compliance with standards of care for chronic diseases is performed. A previous ecological study demonstrated that compliance with standards of care could be reliably estimated on regional level using administrative databases. This study compares estimates based on administrative data with estimates based on GP records for the same persons, to understand whether ecological fallacy played a role in the results of the previous study...
2017: PloS One
https://www.readbyqxmd.com/read/29232260/high-alert-medication-stratification-tool-revised-an-exploratory-study-of-an-objective-standardized-medication-safety-tool
#9
Natalie C Washburn, Heather A Dossett, Andrew C Fritschle, Kerri E Degenkolb, Monica R Macik, Todd A Walroth
OBJECTIVE: To develop an objective tool designed to standardize the identification of high-alert medications (HAMs) according to patient safety risk. METHODS: Medications were evaluated using the High-Alert Medication Stratification Tool (HAMST). Tool revision occurred through assessing medications on an organization-approved HAM list and comparing scores with control medications not included on the list. Because of variations in HAMST interpretation by end users in interdisciplinary committees, a revision of the scoring tool was completed to create the High-Alert Medication Stratification Tool-Revised (HAMST-R), and the assessment was repeated...
December 12, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/29232195/crossover-design-in-transcranial-direct-current-stimulation-studies-on-motor-learning-potential-pitfalls-and-difficulties-in-interpretation-of-findings
#10
Mana Biabani, Michael Farrell, Maryam Zoghi, Gary Egan, Shapour Jaberzadeh
Crossover designs are used by a high proportion of studies investigating the effects of transcranial direct current stimulation (tDCS) on motor learning. These designs necessitate attention to aspects of data collection and analysis to take account of design-related confounds including order, carryover, and period effects. In this systematic review, we appraised the method sections of crossover-designed tDCS studies of motor learning and discussed the strategies adopted to address these factors. A systematic search of 10 databases was performed and 19 research papers, including 21 experimental studies, were identified...
December 12, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29232137/inhibition-of-human-cyp3a4-by-rationally-designed-ritonavir-like-compounds-impact-and-interplay-of-the-side-group-functionalities
#11
Eric R Samuels, Irina Sevrioukova
Structure-function relationships of nine rationally designed ritonavir-like compounds were investigated to better understand the ligand binding and inhibitory mechanism in human drug-metabolizing cytochrome P450 3A4 (CYP3A4). The analogs had a similar backbone and pyridine and tert-butyloxycarbonyl (Boc) as the heme-ligating and terminal groups, respectively. N-Isopropyl, N-cyclopentyl, or N-phenyl were the R1-side group substituents alone (compounds 5a-c) or in combination with phenyl or indole at the R2 position (8a-c and 8d-f subseries, respectively)...
December 12, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29232036/diurnal-variations-in-intraocular-pressure-and-central-corneal-thickness-and-the-correlation-between-these-factors-in-dogs
#12
Alicia Garzón-Ariza, Alicia Guisado, Alba Galán, Eva Martín-Suárez
OBJECTIVE: To study the diurnal variation in intraocular pressure (IOP) and central corneal thickness (CCT) in healthy Beagles by rebound tonometry and ultrasonic pachymetry, respectively, in addition to determining whether a correlation exists between these two variables. ANIMALS STUDIED: Twenty eyes from 10 healthy Beagle dogs were included in the study. PROCEDURES: The IOP and CCT were measured by rebound tonometry and ultrasonic pachymetry, respectively, at 2-h intervals over an 8-hour period between 10:00 and 18:00...
December 12, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29231771/spinal-metastasis-with-neurologic-deficits
#13
Panagiotis Tsagozis, Henrik C F Bauer
Background and purpose - A significant number of patients with spinal metastases are treated non-surgically, but may need surgical treatment at a later stage due to progression of symptoms. Therefore, we investigated the need for late surgical decompression in patients with spinal metastasis who were initially deemed as non-surgical candidates, as well as the outcome of late surgery. Patients and methods - 116 patients who were referred to the orthopedic oncology department between 2002 and 2011 due to spinal metastasis with neurologic symptoms were deemed to be non-surgical candidates...
December 12, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/29231511/-meridian-differentiation-of-low-back-pain-in-neijing-inner-canon-of-yellow-emperor
#14
Qiulei Guo, Wenrui Jia, Qisheng Sun, Qiying Guo, Ying Huang, Zongyu Jin, Fangyuan Yang, He Wang, He Zhan, Qingguo Liu
There are various contents about diagnosis and treatment of low back pain in Neijing (Inner Canon of Yellow Emperor), which are closely related to meridians and collaterals, forming a complete theoretical system of meridian differentiation for low back pain. Its theory and application are interpreted in this paper from five main aspects, including 18 meridians and collaterals densely distributing in the tendons and bones of the waist, the pathogenesis of low back pain lying in the disorders of the meridian qi and blood, the nature of low back pain being reflected by the color and shape of meridians and collaterals, the disordered meridians of low back pain being first identified based on syndrome differentiation, the acupuncture prescription being selected according to meridian differentiation...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231504/-explanation-on-acupoint-intention
#15
Feng Shen
The spiritual qi "circulating" "exiting and entering", and "nothing relevant with skin, flesh, tendon and bone" are the clues to understand the original intention of acupoint recorded in Lingshu (Miraculous Pivota). In the paper, regarding the interpretation of these words and phrases in Shuowen Jiezi (Origin of Chinese Characters), in combination with TCM theory, the connotations of acupoint are summarized in 4 aspects, including the essential characteristics of the changes in the antipathogenic qi, functional property of pathway communication, the clinical features of diagnosis and treatment and the three-dimensional structural characteristics...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231489/-origin-exploration-of-the-fifty-nine-acupoints-for-febrile-disease
#16
Guangyi Li
Fifty-nine acupoints for febrile disease is recorded in Huangdi Neijing (Huangdi's Internal Classics). By analyzing the combination of these acupoints, the writer discovered the acupoint composition and detected their origins from Huangdi's Internal Classics, in which the terms biaoben, qijie and beishu are involved in the theoretic evidence. The writer thought the "fifty-nine acupoints for febrile disease" implied the self-evolution of some acupuncture school in ancient time, which was formed by absorbing the theoretic experiences of the other schools...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231128/exploring-the-experiences-of-persons-who-frequently-visit-the-emergency-department-for-mental-health-related-reasons
#17
Amanda Digel Vandyk, Lisa Young, Colleen MacPhee, Katharine Gillis
In this qualitative study, the experiences of persons who frequently visit the emergency department (ED) for mental health-related reasons were explored. Interpretive Description guided the design, and data were collected through interviews with 10 adults who made 12+ ED visits within a 1-year time frame (2015). Thematic analysis was used to analyze data inductively. The participants' experiences were described with the help of three themes emerging from the data: The Experience, The Providers, and Protective Factors...
December 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/29231090/esophageal-dysmotility-in-patients-following-total-laryngectomy
#18
Teng Zhang, Julia Maclean, Michal Szczesniak, Paul P Bertrand, Harry Quon, Raymond K Tsang, Peter I Wu, Peter Graham, Ian J Cook
Objectives Dysphagia is common in total laryngectomees, with some symptoms suggesting esophageal dysmotility. Tracheoesophageal (TE) phonation requires effective esophagopharyngeal air passage. Hence, esophageal dysmotility may affect deglutition or TE phonation. This study aimed to determine (1) the characteristics of esophageal dysmotility in laryngectomees, (2) whether clinical history is sensitive in detecting esophageal dysmotility, and (3) the relationship between esophageal dysmotility and TE prosthesis dysfunction...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29230975/negative-pap-tests-in-women-with-high-grade-cervical-lesions-on-follow-up-biopsies-contributing-factors-and-role-of-human-papillomavirus-genotyping
#19
Steven Goodman, Roxanne R Mody, Donna Coffey, Blythe K Gorman, Eric Luna, Donna Armylagos, Mary R Schwartz, Dina R Mody, Yimin Ge
BACKGROUND: Previous studies have indicated that negative Papanicolaou (Pap) tests can precede high-grade cervical lesions (HGCL) on biopsy. This study aims to determine the contributing factors for cytologic discrepancy and the potential role of human papilloma virus (HPV) testing in risk evaluation of women with negative Pap tests. METHODS: Of 42,797 Pap tests interpreted as negative for intraepithelial lesion or malignancy (NILM) from March 1, 2013 to December 30, 2014, 426 had available HPV testing and follow-up biopsy...
December 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29230939/normative-values-and-factors-affecting-water-perfused-esophageal-high-resolution-impedance-manometry-for-a-chinese-population
#20
P-H Tseng, R K M Wong, J-F Wu, C-C Chen, C-H Tu, Y-C Lee, H-C Lee, H-P Wang, M-S Wu
BACKGROUND: Combined esophageal high-resolution impedance manometry (HRIM) measures multiple pressures and bolus transit simultaneously, facilitating detailed assessment of esophageal motility. Currently, normative values for water-perfused HRIM systems for Chinese populations are lacking. METHODS: Healthy volunteers were enrolled for comprehensive anthropometric measures, blood biochemistry tests, and an HRIM study using 22 water-perfused pressure sensors and 12 impedance channels...
December 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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