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https://www.readbyqxmd.com/read/29656628/cerebral-thromboembolic-events-during-anterior-cervical-spine-surgery-retrospective-case-series-study-with-diffusion-weighted-magnetic-resonance-imaging-follow-up-in-the-immediate-postoperative-period
#1
Seok-Won Chung, Min-Soo Kang, Sang-Ho Lee, Shin-Young Lee, Yong-Hwan Shin, Chan-Hong Park
OBJECTIVE: We evaluated the efficacy of diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting perioperative cerebral thromboembolic events after anterior cervical discectomy and fusion (ACDF). METHODS: This retrospective case series included 51 consecutive patients that underwent ACDF. To assess baseline presence of plaque or stenosis, all patients were assessed for risk factors of cerebrovascular events and underwent carotid ultrasound preoperatively and cerebral DW-MRI was performed in all patients postoperatively, with areas of high signal intensity interpreted as a cerebral thromboembolic event...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656607/expert-agreement-in-the-interpretation-of-lung-ultrasound-studies-performed-on-mechanically-ventilated-patients
#2
Scott J Millington, Robert T Arntfield, Robert Jie Guo, Seth Koenig, Pierre Kory, Vicki Noble, Haney Mallemat, Jordan R Schoenherr
OBJECTIVES: Although lung ultrasound (US) has been shown to have high diagnostic accuracy in patients presenting with acute dyspnea, its precision in critically ill patients is unknown. We investigated common areas of agreement and disagreement by studying 6 experts as they interpreted lung US studies in a cohort of intensive care unit (ICU) patients. METHODS: A previous study by our group asked experts to rate the quality of 150 lung US studies performed by 10 novices in a population of mechanically ventilated patients...
April 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29656593/review-article-investigations-and-the-pregnant-woman-in-the-emergency-department-part-1-laboratory-investigations
#3
REVIEW
Adam Morton, Stephanie Teasdale
Accurate assessment of the pregnant patient in the ED depends on knowledge of physiological changes in pregnancy, and how these changes may impact on pathology tests, appearance on point-of-care ultrasound and electrocardiography. In addition the emergency physician needs to be cognisant of disorders that are unique to or more common in pregnancy. Part 1 of this review addresses potential deviations in laboratory investigation reference intervals resulting from physiological alterations in pregnancy, and the important causes of abnormal laboratory results in pregnancy...
April 15, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29656484/did-poor-eyesight-influence-goya-s-late-works-medicine-and-art-history-in-search-for-an-interpretation-of-goya-s-late-paintings
#4
José M Pérez-Trullén, Francisco J Ascaso, María J Auría
PURPOSE: The aim of this article is to 'determine' the scope of Goya's eyesight difficulties and assess the extent to which those difficulties might explain his style of painting in the last years of his life. METHODS: We analyse the correspondence and late works of the Aragonese painter Francisco de Goya y Lucientes (1746-1828), who has been admired for his use of colour, his energetic loose brushstrokes, his disregard for details and his bold compositions, as well as for his different artistic styles throughout his life...
April 15, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29656446/hemodynamic-response-function-hrf-variability-confounds-resting-state-fmri-functional-connectivity
#5
D Rangaprakash, Guo-Rong Wu, Daniele Marinazzo, Xiaoping Hu, Gopikrishna Deshpande
PURPOSE: fMRI is the convolution of the hemodynamic response function (HRF) and unmeasured neural activity. HRF variability (HRFv) across the brain could, in principle, alter functional connectivity (FC) estimates from resting-state fMRI (rs-fMRI). Given that HRFv is driven by both neural and non-neural factors, it is problematic when it confounds FC. However, this aspect has remained largely unexplored even though FC studies have grown exponentially. We hypothesized that HRFv confounds FC estimates in the brain's default-mode-network...
April 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29656430/individual-differences-in-stop-related-activity-are-inflated-by-the-adaptive-algorithm-in-the-stop-signal-task
#6
Nicholas D'Alberto, Bader Chaarani, Catherine A Orr, Philip A Spechler, Matthew D Albaugh, Nicholas Allgaier, Alexander Wonnell, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Patricia J Conrod, Sylvane Desrivières, Herta Flor, Juliane H Fröhner, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Itterman, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Trevor W Robbins, Michael N Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Alexandra S Potter, Hugh Garavan
Research using the Stop Signal Task employing an adaptive algorithm to accommodate individual differences often report inferior performance on the task in individuals with ADHD, OCD, and substance use disorders compared to non-clinical controls. Furthermore, individuals with deficits in inhibitory control tend to show reduced neural activity in key inhibitory regions during successful stopping. However, the adaptive algorithm systematically introduces performance-related differences in objective task difficulty that may influence the estimation of individual differences in stop-related neural activity...
April 15, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29656353/adsorption-of-cu-ii-and-ni-ii-from-aqueous-solutions-by-taro-stalks-chemically-modified-with-diethylenetriamine
#7
Yao Lu, Deliang He, Huibin Lei, Jun Hu, Houqiang Huang, Huiying Ren
Taro stalks (TS) were modified by diethylenetriamine (DETA) to obtain the modified taro stalks adsorbents (recorded as MTSA). This kind of raw material is unprecedented and the method of modification is relatively simple. The physicochemical properties of MTSA were characterized by scanning electron microscope (SEM), FTIR, and zeta potential analyzer. The capacity of MTSA for adsorbing heavy metals under different influencing factors was tested by UV-visible spectrophotometer. The results indicated that the gaps between the microspheres of MTSA are more, which are conducive to adsorption...
April 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29656241/material-properties-of-ultra-high-molecular-weight-polyethylene-comparison-of-tension-compression-nanomechanics-and-microstructure-across-clinical-formulations
#8
Louis G Malito, Sofia Arevalo, Adam Kozak, Stephen Spiegelberg, Anuj Bellare, Lisa Pruitt
This is the first study to simultaneously measure material properties in tension, compression, nanoindentation as well as microstructure (crystallinity and lamellar level properties) across a wide variety of clinically relevant ultra-high molecular weight polyethylene (UHMWPE) formulations. Methodologies for the measurement of UHMWPE mechanical properties-namely elastic modulus, yield stress, yield strain, ultimate strength, energetic toughness, Poisson's ratio, hardness and constitutive variables-are evaluated...
April 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29656086/hiv-1-non-r5-tropism-correlates-with-a-larger-size-of-the-cellular-viral-reservoir-and-a-detectable-residual-viremia-in-patients-under-suppressive-art
#9
Francesca Lombardi, Simone Belmonti, Lucrezia Rapone, Alberto Borghetti, Arturo Ciccullo, Roberta Gagliardini, Gianmaria Baldin, Francesca Montagnani, Davide Moschese, Arianna Emiliozzi, Barbara Rossetti, Andrea De Luca, Simona Di Giambenedetto
BACKGROUND: The influence of HIV-1 co-receptor usage on the course of therapy in subjects fully responding to ART has been poorly investigated. OBJECTIVES: To explore the relationship between co-receptor tropism and cellular reservoir size, residual viremia and subsequent virological outcome in ART-treated patients with HIV-1 RNA stable <50 copies/mL. STUDY DESIGN: Viral co-receptor usage was predicted by viral env DNA sequencing with geno2pheno interpretation (FPR20%) and classified as R5 and non-R5...
April 2, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29656081/utilizing-dipole-dipole-cross-correlated-relaxation-for-the-measurement-of-angles-between-pairs-of-opposing-c%C3%AE-h%C3%AE-c%C3%AE-h%C3%AE-bonds-in-anti-parallel-%C3%AE-sheets
#10
T Michael Sabo, Vytautas Gapsys, Korvin F A Walter, R Bryn Fenwick, Stefan Becker, Xavier Salvatella, Bert L de Groot, Donghan Lee, Christian Griesinger
Dipole-dipole cross-correlated relaxation (CCR) between two spin pairs is rich with macromolecular structural and dynamic information on inter-nuclear bond vectors. Measurement of short range dipolar CCR rates has been demonstrated for a variety of inter-nuclear vector spin pairs in proteins and nucleic acids, where the multiple quantum coherence necessary for observing the CCR rate is created by through-bond scalar coupling. In principle, CCR rates can be measured for any pair of inter-nuclear vectors where coherence can be generated between one spin of each spin pair, regardless of both the distance between the two spin pairs and the distance of the two spins forming the multiple quantum coherence...
April 12, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29656051/the-private-journey-an-interpretative-phenomenological-analysis-of-exclusive-breastfeeding
#11
Samantha J Charlick, Lois McKellar, Andrea L Gordon, Jan Pincombe
BACKGROUND: Exclusive breast milk provides complete nutrition for a baby's first six months of life. In Australia, breastfeeding initiation rates are high, however duration rates are low. Although numerous studies have explored the reasons behind low levels of breastfeeding, few have examined the experiences of women who maintain exclusive breastfeeding for the recommended six-month duration. AIM: This paper will present an in-depth, idiographic interpretation of first-time mothers' experience of exclusive breastfeeding for six months in Australia...
April 11, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29656014/and-then-i-saw-her-race-race-based-expectations-affect-infants-word-processing
#12
Drew Weatherhead, Katherine S White
How do our expectations about speakers shape speech perception? Adults' speech perception is influenced by social properties of the speaker (e.g., race). When in development do these influences begin? In the current study, 16-month-olds heard familiar words produced in their native accent (e.g., "dog") and in an unfamiliar accent involving a vowel shift (e.g., "dag"), in the context of an image of either a same-race speaker or an other-race speaker. Infants' interpretation of the words depended on the speaker's race...
April 12, 2018: Cognition
https://www.readbyqxmd.com/read/29655938/delineation-of-early-brain-development-from-fetuses-to-infants-with-diffusion-mri-and-beyond
#13
REVIEW
Minhui Ouyang, Jessica Dubois, Qinlin Yu, Pratik Mukherjee, Hao Huang
Dynamic macrostructural and microstructural changes take place from the mid-fetal stage to 2 years after birth. Delineating brain structural changes during this early developmental period provides new insights into the complicated processes of both typical brain development and the pathological mechanisms underlying various psychiatric and neurological disorders including autism, attention deficit hyperactivity disorder and schizophrenia. Decades of histological studies have identified strong spatial and functional gradients of maturation in human brain gray and white matter...
April 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29655510/histopathological-validation-of-optical-coherence-tomography-findings-of-the-coronary-arteries
#14
REVIEW
Kenichi Fujii, Rika Kawakami, Seiichi Hirota
Optical coherence tomography (OCT), a catheter-based imaging modality for the visualization of coronary arteries, is widely used during percutaneous coronary intervention to improve the understanding of the anatomy of coronary artery stenosis and to elucidate the mechanisms of atherosclerosis. In this review, we provide a short description of the histopathological validations of OCT for visualizing atherosclerotic plaques and vascular healing response after drug-eluting stent (DES) implantation. Because OCT measures the intensity of light returning from within a tissue, tissue having a higher heterogeneity of optical index of refraction, such as microcalcification deposition and foam cell accumulation on the luminal surface, may exhibit stronger optical scattering that appears as a thin-cap fibroatheroma image...
April 11, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29655499/genetic-testing-in-clinical-settings
#15
Nora Franceschini, Amber Frick, Jeffrey B Kopp
Genetic testing is used for screening, diagnosis, and prognosis of diseases consistent with a genetic cause and to guide drug therapy to improve drug efficacy and avoid adverse effects (pharmacogenomics). This In Practice review aims to inform about DNA-related genetic test availability, interpretation, and recommended clinical actions based on results using evidence from clinical guidelines, when available. We discuss challenges that limit the widespread use of genetic information in the clinical care setting, including a small number of actionable genetic variants with strong evidence of clinical validity and utility, and the need for improving the health literacy of health care providers and the public, including for direct-to-consumer tests...
April 11, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29655458/standardization-of-bnp-and-nt-probnp-immunoassays-in-light-of-the-diverse-and-complex-nature-of-circulating-bnp-related-peptides
#16
Alexander G Semenov, Evgeniya E Feygina
Brain natriuretic peptide (BNP) and the N-terminal fragment of the BNP precursor (NT-proBNP) are widely used as heart failure (HF) biomarkers. Since the discovery of BNP in 1988, much effort has been allocated to the precise detection of BNP and NT-proBNP levels for reliable HF diagnostics. As a result, measurements of these biomarkers are globally accepted and used in clinical practice for the diagnosis of acute and chronic HF, risk stratification, and monitoring response to therapy. Several immunoassays specific for BNP and NT-proBNP are currently commercially available...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29655425/estimating-the-number-of-components-and-detecting-outliers-using-angle-distribution-of-loading-subspaces-adls-in-pca-analysis
#17
Y J Liu, T Tran, G Postma, L M C Buydens, J Jansen
Principal Component Analysis (PCA) is widely used in analytical chemistry, to reduce the dimensionality of a multivariate data set in a few Principal Components (PCs) that summarize the predominant patterns in the data. An accurate estimate of the number of PCs is indispensable to provide meaningful interpretations and extract useful information. We show how existing estimates for the number of PCs may fall short for datasets with considerable coherence, noise or outlier presence. We present here how Angle Distribution of the Loading Subspaces (ADLS) can be used to estimate the number of PCs based on the variability of loading subspace across bootstrap resamples...
August 22, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29655346/spatially-resolved-proton-momentum-distributions-in-kdp-from-first-principles
#18
Edgar A Engel
The ferroelectric to paraelectric (PE) phase transition of KH2 PO4 (KDP) is investigated as a stringent test of the first-principles, normal modes framework proposed for calculating anharmonic quantum nuclear motion. Accurate spatially resolved momentum distribution functions (MDFs) are directly calculated from the nuclear wavefunction, overcoming the limitations of path-integral molecular dynamics methods. They indicate coherent, correlated tunneling of protons across hydrogen bonds in the PE phase in agreement with neutron Compton scattering data and reproduces the key features of the experimental MDF...
April 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29653404/static-postural-control-among-school-aged-youth-with-down-syndrome-a-systematic-review
#19
REVIEW
Christophe Maïano, Olivier Hue, Danielle Tracey, Geneviève Lepage, Alexandre J S Morin, Grégory Moullec
BACKGROUND: Youth with Down syndrome are characterized by motor delays when compared to typically developing (TD) youth, which may be explained by a lower postural control or reduced postural tone. OBJECTIVE: In the present article, we summarize research comparing the static postural control, assessed by posturography, between youth with Down syndrome and TD youth. METHODS: A systematic literature search was performed in 10 databases and seven studies, published between 2001 and 2017, met our inclusion criteria...
March 16, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29653383/characterizing-fretting-damage-in-different-test-media-for-cardiovascular-device-durability-testing
#20
J D Weaver, L Ramirez, S Sivan, M Di Prima
In vitro durability tests of cardiovascular devices are often used to evaluate the potential for fretting damage during clinical use. Evaluation of fretting damage is important because severe fretting can concentrate stress and lead to the loss of structural integrity. Most international standards call for the use of phosphate buffered saline (PBS) for such tests although there has been little evidence to date that the use of PBS is appropriate in terms of predicting the amount of fretting damage that would occur in vivo...
April 4, 2018: Journal of the Mechanical Behavior of Biomedical Materials
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