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https://www.readbyqxmd.com/read/27908944/use-of-neuromuscular-blockers-during-therapeutic-hypothermia-after-cardiac-arrest-a-nursing-protocol
#1
Coraline Boulila, Samia Ben Abdallah, Aude Marincamp, Vincent Coic, Romuald Lauverjat, Nicole Ericher, Wulfran Bougouin, Jean-Paul Mira, Alain Cariou, Guillaume Geri
BACKGROUND: Neuromuscular blockers used to prevent shivering during therapeutic hypothermia in comatose patients after out-of-hospital cardiac arrest are associated with adverse events. OBJECTIVE: To assess the influence of a nurse-implemented protocol on use of neuromuscular blockers in patients treated with 24-hour therapeutic hypothermia after out-of-hospital cardiac arrest. METHODS: A before and after study was done in a 24-bed cardiac arrest center...
December 2016: Critical Care Nurse
https://www.readbyqxmd.com/read/27904586/the-evaluation-of-effects-two-different-doses-of-hydrocortisone-on-the-intensity-of-perioperative-shivering-in-elective-surgery-under-spinal-anesthesia-a-double-blind-randomized-controlled-trial-study
#2
Mohammadreza Safavi, Azim Honarmand, Fatemeh Khosravi, Hamid Sariazdi, Masoud Nazem
BACKGROUND: Post- and intra-operative shivering is one of the most complications of spinal anesthesia so recommend a suitable drug with at least complications for prevention and control of postoperative shivering. This current study aimed to compare the preventive effect of hydrocortisone on intra- and post-operative shivering in patients undergoing surgery with spinal anesthesia. MATERIALS AND METHODS: In a clinical trial study, ninety patients who candidate for surgery with spinal anesthesia were selected and randomly divided into three groups...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27901032/from-the-past-to-future-from-energy-expenditure-to-energy-intake-to-energy-expenditure
#3
REVIEW
M J Müller, C Geisler
Although most recent research on energy balance focusses on energy intake (EI) there is still need to think about both sides of the energy balance. Current research on energy expenditure (EE) relates to metabolic adaptation to negative energy balance, mitochondrial metabolism associated with aging, obesity and type 2 diabetes mellitus, the role of EE in hunger and appetite control, non-shivering thermogenesis and brown adipose tissue activity, cellular bioenergetics as a target of obesity treatment and the evolutionary and ecological determinants of EE in humans and other primates...
November 30, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27900258/adipocyte-specific-hypoxia-inducible-gene-2-promotes-fat-deposition-and-diet-induced-insulin-resistance
#4
Marina T DiStefano, Rachel J Roth Flach, Ozlem Senol-Cosar, Laura V Danai, Joseph V Virbasius, Sarah M Nicoloro, Juerg Straubhaar, Sezin Dagdeviren, Martin Wabitsch, Olga T Gupta, Jason K Kim, Michael P Czech
OBJECTIVE: Adipose tissue relies on lipid droplet (LD) proteins in its role as a lipid-storing endocrine organ that controls whole body metabolism. Hypoxia-inducible Gene 2 (Hig2) is a recently identified LD-associated protein in hepatocytes that promotes hepatic lipid storage, but its role in the adipocyte had not been investigated. Here we tested the hypothesis that Hig2 localization to LDs in adipocytes promotes adipose tissue lipid deposition and systemic glucose homeostasis. METHOD: White and brown adipocyte-deficient (Hig2(fl/fl) × Adiponection cre+) and selective brown/beige adipocyte-deficient (Hig2(fl/fl) × Ucp1 cre+) mice were generated to investigate the role of Hig2 in adipose depots...
December 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27892859/the-identification-of-potential-behavioural-indicators-of-pain-in-periparturient-sows
#5
Sarah H Ison, Susan Jarvis, Kenneth M D Rutherford
Periparturient pain is a welfare concern and could contribute to piglet losses. This has led to studies investigating post-farrowing analgesia. A clear reduction in pain has not been demonstrated, partly due to a lack of pain indicators. This study quantified behaviours as potential pain indicators (PPIn) in sows: i) before, during and after farrowing, and ii) 2min before and after piglet births. Twenty-five sows were observed during and after, and ten pre-farrowing. Behaviour recorded included: 1) back leg forward (back leg pulled forward and/or in); 2) tremble (movement as if shivering); 3) back arch (leg(s) stretch forming an arched back); 4) paw (leg scraped in pawing motion); and 5) tail flick (tail moved rapidly up and down)...
October 6, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27875631/intravenous-nutrients-for-preventing-inadvertent-perioperative-hypothermia-in-adults
#6
REVIEW
Sheryl Warttig, Phil Alderson, Sharon R Lewis, Andrew F Smith
BACKGROUND: Inadvertent perioperative hypothermia (a drop in core temperature to below 36°C) occurs because normal temperature regulation is disrupted during surgery, mainly because of the effects of anaesthetic drugs and exposure of the skin for prolonged periods. Many different ways of maintaining body temperature have been proposed, one of which involves administration of intravenous nutrients during the perioperative period that may reduce heat loss by increasing metabolism, thereby increasing heat production...
November 22, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27859725/effects-of-menthol-application-on-the-skin-during-prolonged-immersion-in-swimmers-and-controls
#7
P G Botonis, N D Geladas, S N Kounalakis, E D Cherouveim, M D Koskolou
We hypothesized that menthol application on the skin would enhance vasoconstriction of subjects immersed in cool water, which would reduce heat loss and rectal temperature (Tre) cooling rate. Furthermore, it was hypothesized that this effect would be greater in individuals acclimatized to immersion in 24 °C water, such as swimmers. Seven swimmers (SW) and seven physical education students (CON) cycled at 60% VO2 max until Tre attained 38 °C, and were then immediately immersed in stirred water maintained at 24 °C on two occasions: without (NM) and with (M; 4...
November 18, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27856931/5-ht3-receptor-antagonists-for-the-prevention-of-postoperative-shivering-a-meta-analysis
#8
Chengmao Zhou, Yu Zhu, Zhen Liu, Lin Ruan
OBJECTIVE: We evaluated the efficacy of 5-HT3 receptor antagonists for the prevention of postoperative shivering. METHODS: We searched PubMed, the Cochrane Library, EMBASE and Web of Knowledge to find randomized controlled trials (RCT) of 5-HT3 receptor antagonists for the prevention of postoperative shivering. Two researchers independently screened studies, extracted data, and assessed quality in accordance with the inclusion and exclusion criteria, and then conducted a meta-analysis using RevMan 5...
November 17, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27855944/-the-effects-of-intra-cerebroventricular-administered-rocuronium-on-the-central-nervous-system-of-rats-and-determination-of-its-epileptic-seizure-inducing-dose
#9
Mehmet Baykal, Necati Gökmen, Alper Doğan, Serhat Erbayraktar, Osman Yılmaz, Elvan Ocmen, Hale Aksu Erdost, Atalay Arkan
BACKGROUND: The aim of this study was to investigate the effects of intracerebroventricularly administered rocuronium bromide on the central nervous system, determine the seizure threshold dose of rocuronium bromide in rats, and investigate the effects of rocuronium on the central nervous system at 1/5, 1/10, and 1/100 dilutions of the determined seizure threshold dose. METHODS: A permanent cannula was placed in the lateral cerebral ventricle of the animals. The study was designed in two phases...
November 14, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27836993/diacylglycerol-acyltransferase-2-dgat2-links-glucose-utilization-to-fatty-acid-oxidation-in-the-brown-adipocytes
#10
Zehra Irshad, Federica Dimitri, Mark Christian, Victor A Zammit
Brown adipose tissue uptake of glucose and fatty acids is very high during non-shivering thermogenesis. Adrenergic stimulation markedly increases glucose uptake, de novo lipogenesis and FA oxidation simultaneously. The mechanism that enables this concerted response has hitherto been unknown. Here we find that in a primary brown adipocytes and brown adipocyte-derived cell line (IMBAT-1) acute inhibition and longer-term knockdown of DGAT2 links the increased de novo synthesis of fatty acids from glucose to a pool of TG which is simultaneously hydrolysed, providing FA for mitochondrial oxidation...
November 11, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27829055/a-novel-approach-for-studying-the-physiology-and-pathophysiology-of-myelinated-and-non-myelinated-axons-in-the-cns-white-matter
#11
Lijun Li, Alexander A Velumian, Marina Samoilova, Michael G Fehlings
Advances in brain connectomics set the need for detailed knowledge of functional properties of myelinated and non-myelinated (if present) axons in specific white matter pathways. The corpus callosum (CC), a major white matter structure interconnecting brain hemispheres, is extensively used for studying CNS axonal function. Unlike another widely used CNS white matter preparation, the optic nerve where all axons are myelinated, the CC contains also a large population of non-myelinated axons, making it particularly useful for studying both types of axons...
2016: PloS One
https://www.readbyqxmd.com/read/27812971/efficacy-and-safety-of-dexmedetomidine-as-an-adjuvant-in-epidural-analgesia-and-anesthesia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Xu Zhang, Dong Wang, Min Shi, YuanGuo Luo
BACKGROUND AND OBJECTIVE: Several clinical trials have examined and indicated the usefulness of epidural dexmedetomidine therapy. However, there has been no systematic analysis of the findings of these trials to date. We undertook this systematic review and meta-analysis to investigate the efficacy and safety of epidural dexmedetomidine adjunctive therapy in different surgical procedures. MATERIALS AND METHODS: We searched EMBASE, PubMed, the Cochrane Library, and the Clinical Trials...
November 4, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27797961/a-replication-defective-human-cytomegalovirus-vaccine-for-prevention-of-congenital-infection
#13
Dai Wang, Daniel C Freed, Xi He, Fengsheng Li, Aimin Tang, Kara S Cox, Sheri A Dubey, Suzanne Cole, Muneeswara Babu Medi, Yaping Liu, Jingyuan Xu, Zhi-Qiang Zhang, Adam C Finnefrock, Liping Song, Amy S Espeseth, John W Shiver, Danilo R Casimiro, Tong-Ming Fu
Congenital human cytomegalovirus (HCMV) infection occurs in ~0.64% of infants born each year in the United States and is the leading nongenetic cause of childhood neurodevelopmental disabilities. No licensed HCMV vaccine is currently available. Natural immunity to HCMV in women before pregnancy is associated with a reduced risk of fetal infection, suggesting that a vaccine is feasible if it can reproduce immune responses elicited by natural infection. On the basis of this premise, we developed a whole-virus vaccine candidate from the live attenuated AD169 strain, with genetic modifications to improve its immunogenicity and attenuation...
October 26, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27766254/increased-cost-of-motor-activity-and-heat-transfer-between-non-shivering-thermogenesis-motor-activity-and-thermic-effect-of-feeding-in-mice-housed-at-room-temperature-implications-in-pre-clinical-studies
#14
Patrick C Even, Anne Blais
The components of energy expenditure, total metabolic rate (TMR), resting metabolic rate (RMR), thermogenic response to feeding (TEF), activity, and cost of activity were measured in fed and fasted mice housed at 22 and 30°C. Mice housed at 22°C had more than two times larger TMR and RMR. Mice at 22°C were less active when fasted but more active when fed. Cost of activity was nearly doubled in the fasted and in the fed state. Analysis of the short-term relation between TMR, RMR, and bouts of activity showed that, at 22°C, the bouts of activity induced a decrease in the intensity of RMR that reflected the reduced need for thermal regulation induced by the heat released from muscular contraction...
2016: Frontiers in Nutrition
https://www.readbyqxmd.com/read/27756210/prevalence-associated-factors-and-treatment-of-post-spinal-shivering-in-a-sub-saharan-tertiary-hospital-a-prospective-observational-study
#15
Tonny Stone Luggya, Richard Nicholas Kabuye, Cephas Mijumbi, Joseph Bahe Tindimwebwa, Andrew Kintu
BACKGROUND: Surgery and anaesthesia cause shivering due to thermal dysregulation as a compensatory mechanism and is worsened by vasodilatation from spinal anaesthesia that redistributes core body heat. Due to paucity of data Mulago Hospital's post spinal shivering burden is unknown yet it causes discomfort and morbidity. METHODS: Ethical approval was obtained to perform the study among consenting mothers due for elective caesarean section from March to May 2011...
October 18, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27755687/seasonal-control-of-mammalian-energy-balance-recent-advances-in-the-understanding-of-daily-torpor-and-hibernation
#16
Martin Jastroch, Sylvain Giroud, Perry Barrett, Fritz Geiser, Gerhard Heldmaier, Annika Herwig
Endothermic mammals and birds require intensive energy turnover to sustain high body temperatures and metabolic rates. To cope with energetic bottlenecks associated with the change of seasons, and to minimise energy expenditure, complex mechanisms and strategies, such as daily torpor and hibernation, are used. During torpor metabolic depression and low body temperatures save energy. However, these bouts of torpor lasting for hours to weeks are interrupted by active 'euthermic' phases with high body temperatures...
October 18, 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/27755068/clinical-practice-guidelines-for-sustained-neuromuscular-blockade-in-the-adult-critically-ill-patient
#17
Michael J Murray, Heidi DeBlock, Brian Erstad, Anthony Gray, Judi Jacobi, Che Jordan, William McGee, Claire McManus, Maureen Meade, Sean Nix, Andrew Patterson, M Karen Sands, Richard Pino, Ann Tescher, Richard Arbour, Bram Rochwerg, Catherine Friederich Murray, Sangeeta Mehta
OBJECTIVE: To update the 2002 version of "Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient." DESIGN: A Task Force comprising 17 members of the Society of Critical Medicine with particular expertise in the use of neuromuscular-blocking agents; a Grading of Recommendations Assessment, Development, and Evaluation expert; and a medical writer met via teleconference and three face-to-face meetings and communicated via e-mail to examine the evidence and develop these practice guidelines...
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27747684/confusion-between-two-amphotericin-b-formulations-leading-to-a-paediatric-rehospitalisation
#18
Mapi Fleury, Caroline Fonzo-Christe, Charline Normand, Pascal Bonnabry
A heavily immunosuppressed, 43-kg, 9-year-old patient was recovering from a bone marrow transplant. Primary prophylaxis against invasive fungal infections was liposomal amphotericin B (AmBisome(®), 2.3 mg/kg [100 mg] two times per week). Once home, following a first amphotericin B infusion, he presented with strong diarrhoea and vomiting; this was repeated after the second infusion. The clinical situation worsened rapidly and the patient was rehospitalised. On admission, he presented with acute renal failure...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27746565/evaluation-of-antihypotensive-techniques-for-cesarean-section-under-spinal-anesthesia-rapid-crystalloid-hydration-versus-intravenous-ephedrine
#19
Kalpana Rajendra Kulkarni, Amruta Girish Naik, Sunetra Girish Deshpande
BACKGROUND: Spinal anesthesia is a preferred technique over general anesthesia for cesarean delivery. It avoids maternal airway related complications, aspiration and neonatal depression. However hypotension following spinal anesthesia can lead to decrease in uterine blood flow and neonatal hypoxia. AIMS: We aimed to evaluate the efficacy of 15 mL.kg- 1of crystalloid preloading versus prophylactic intravenous bolus of 10 mg ephedrine as an antihypotensive measure for cesarean section...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27746526/efficacy-of-lipophilic-vs-lipophobic-opioids-in-addition-to-hyperbaric-bupivacaine-for-patients-undergoing-lower-segment-caeserean-section
#20
Amit Agrawal, Veena Asthana, J P Sharma, Vineeta Gupta
BACKGROUND: Subarachnoid block is the preferred technique for providing anesthesia for patients undergoing cesarean section. Various pharmacological agents in added to local anesthetics (LA) modify their original effects in terms of block characteristics and quality of analgesia. However, there is ongoing debate about this practice of using adjuncts with LA. We tested whether addition of lipophilic versus lipophobic opioids to LA gives any clinical benefits to maternal and fetal outcome when used in these patients requiring spinal anesthesia...
September 2016: Anesthesia, Essays and Researches
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