keyword
https://read.qxmd.com/read/38536508/examining-racial-disparities-in-utilization-rate-and-perioperative-outcomes-following-knee-and-hip-arthroplasty
#1
JOURNAL ARTICLE
Tyler Thorne, Scott Nishioka, Krystin Wong, Dylan R Y Lawton, Sian Yik Lim, Cass K Nakasone
BACKGROUND: Previous arthroplasty utilization research predominantly examined Black and White populations within the US. This is the first known study to examine utilization and complications in poorly studied minority racial groups such as Asians and Native Hawaiian/Pacific-Islanders (NHPI) as compared to Whites. RESULTS: Data from 3304 primary total hip and knee arthroplasty patients (2011 to 2019) were retrospectively collected, involving 1789 Asians (52.2%), 1164 Whites (34%) and 320 Native Hawaiians/Pacific Islanders (NHPI) (9...
March 27, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38536174/cdc-s-hospital-onset-clostridioides-difficile-prevention-framework-in-a-regional-hospital-network
#2
JOURNAL ARTICLE
Nicholas A Turner, Jay Krishnan, Alicia Nelson, Christopher R Polage, Ronda L Sinkowitz-Cochran, Lucy Fike, David T Kuhar, Preeta K Kutty, Rachel L Snyder, Deverick J Anderson
IMPORTANCE: Despite modest reductions in the incidence of hospital-onset Clostridioides difficile infection (HO-CDI), CDI remains a leading cause of health care-associated infection. As no single intervention has proven highly effective on its own, a multifaceted approach to controlling HO-CDI is needed. OBJECTIVE: To assess the effectiveness of the Centers for Disease Control and Prevention's Strategies to Prevent Clostridioides difficile Infection in Acute Care Facilities Framework (hereafter, the Framework) in reducing HO-CDI incidence...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38535874/association-between-prepregnancy-body-mass-index-and-newborn-breastfeeding-initiation
#3
JOURNAL ARTICLE
Melanie Boyd, Clare C Brown, Anthony Goudie
Background: The benefits of breastfeeding a newborn are well documented. Identification of mothers who do not initiate breastfeeding is essential for developing initiatives to improve breastfeeding initiation. Methods: The study used data from the National Center for Health Statistics (NCHS) National Vital Statistics System (NVSS) birth certificate data (2014-2021) to identifying 15,599,930 in-hospital deliveries. We used multivariable logistic regression to assess the association between seven body mass index (BMI) categories and initiation of breastfeeding before hospital discharge...
March 27, 2024: Breastfeeding Medicine
https://read.qxmd.com/read/38535738/move-to-flow-the-benefits-and-barriers-of-a-physical-activity-nature-based-pilot-programme
#4
JOURNAL ARTICLE
Celia Marcen, Antonio José Cardona-Linares, Francisco Pradas, Miguel Ángel Ortega-Zayas
This study aims to assess the potential benefits and barriers of Move to Flow (MtF), a nature-based physical activity (PA) programme structured in two levels that include movements related to the animal, vegetal, and inert nature. A questionnaire was applied to 133 participants from Spain, Latvia, and Serbia. The instrument was structured in the following sections: socio-economic variables; sports participation; and health and physical condition perception. In addition, the Exercise Benefits and Barriers Scale (EBBS), which assesses these aspects on the physical, psychological, and social levels, was included...
March 6, 2024: Sports
https://read.qxmd.com/read/38534501/improving-generalizability-of-pet-dl-algorithms-list-mode-reconstructions-improve-dotatate-pet-hepatic-lesion-detection-performance
#5
JOURNAL ARTICLE
Xinyi Yang, Michael Silosky, Jonathan Wehrend, Daniel V Litwiller, Muthiah Nachiappan, Scott D Metzler, Debashis Ghosh, Fuyong Xing, Bennett B Chin
Deep learning (DL) algorithms used for DOTATATE PET lesion detection typically require large, well-annotated training datasets. These are difficult to obtain due to low incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and the high cost of manual annotation. Furthermore, networks trained and tested with data acquired from site specific PET/CT instrumentation, acquisition and processing protocols have reduced performance when tested with offsite data. This lack of generalizability requires even larger, more diverse training datasets...
February 27, 2024: Bioengineering
https://read.qxmd.com/read/38533993/a-national-database-analysis-of-the-evolution-of-outcomes-of-surgery-for-anal-melanoma
#6
JOURNAL ARTICLE
Sameh H Emile, Nir Horesh, Zoe Garoufalia, Rachel Gefen, Justin Dourado, Steven D Wexner
BACKGROUND: This study assessed trends in treatment and outcomes of anal melanomas over a 17-year period. METHODS: NCDB was searched for patients with anal melanoma (2004-2020). Receiver-operating characteristic curve analysis was used to determine cutoff year marking increased overall survival (OS) of anal melanoma. Characteristics, treatments, and outcomes in consecutive time periods were compared. RESULTS: A total of 815 patients (mean age: 67...
March 27, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38532550/evaluation-of-tadalafil-supplementation-on-the-neutrophil-lymphocyte-and-the-platelet-lymphocyte-ratios-in-patients-with-erectile-dysfunction-a-prospective-study
#7
JOURNAL ARTICLE
Sameh Fayek GamalEl Din, Nashaat Nabil Ismail, Hanan Hosni Moawad, Iten Mohamed Adel, Ahmad Motawi, Hisham Foaad
OBJECTIVES: We aimed to evaluate the effect of daily 5 mg tadalafil on the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in patients with erectile dysfunction (ED). PATIENTS AND METHODS: 30 subjects with ED were given tadalafil as well as 30 subjects with ED who were not receiving tadalafil were recruited. 30 healthy individuals served as controls. RESULTS: Receiver operating characteristic curve (ROC) showed that the best cut off point of pre-treatment and post treatment NLR in the ED treatment group was found <1...
March 26, 2024: Urologia
https://read.qxmd.com/read/38532363/quantitative-differentiation-of-non-invasive-bladder-urothelial-carcinoma-and-inverted-papilloma-based-on-ct-urography
#8
JOURNAL ARTICLE
Pengfei Jin, Liqin Yang, Yitao Liu, Jiehui Huang, Xu Wang
PURPOSE: To investigate the value of CT urography (CTU) indicators in the quantitative differential diagnosis of bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB). MATERIAL AND METHODS: The clinical and preoperative CTU imaging data of continuous 103 patients with histologically confirmed BUC or IPB were retrospectively analyzed. The imaging data included 6 qualitative indicators and 7 quantitative measures. The recorded clinical information and imaging features were subjected to univariate and multivariate logistic regression analysis to find independent risk factors for BUC, and a combined multi-indicator prediction model was constructed, and the prediction model was visualized using nomogram...
March 26, 2024: BMC Urology
https://read.qxmd.com/read/38532180/a-diverse-panel-of-755-bread-wheat-accessions-harbors-untapped-genetic-diversity-in-landraces-and-reveals-novel-genetic-regions-conferring-powdery-mildew-resistance
#9
JOURNAL ARTICLE
Rebecca Leber, Matthias Heuberger, Victoria Widrig, Esther Jung, Etienne Paux, Beat Keller, Javier Sánchez-Martín
A bread wheat panel reveals rich genetic diversity in Turkish, Pakistani and Iranian landraces and novel resistance loci to diverse powdery mildew isolates via subsetting approaches in association studies. Wheat breeding for disease resistance relies on the availability and use of diverse genetic resources. More than 800,000 wheat accessions are globally conserved in gene banks, but they are mostly uncharacterized for the presence of resistance genes and their potential for agriculture. Based on the selective reduction of previously assembled collections for allele mining for disease resistance, we assembled a trait-customized panel of 755 geographically diverse bread wheat accessions with a focus on landraces, called the LandracePLUS panel...
March 27, 2024: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://read.qxmd.com/read/38529408/identification-of-testis-development-related-genes-by-combining-iso-seq-and-rna-seq-in-zeugodacus-tau
#10
JOURNAL ARTICLE
Peipei Liu, Ziniu Li, Qiuyuan Zhang, Jiao Qiao, Chenjun Zheng, Wenping Zheng, Hongyu Zhang
Introduction: Zeugodacus tau (Walker) is an invasive pest. An effective method to control this pest is the sterile insect technique (SIT). To better apply this technique, it is necessary to understand testis development progression. Methods: Differentially expressed genes (DEGs) during testis development were analyzed by PacBio Iso-Seq and RNA-seq. Results: RNA-Seq library of Z. tau testes on day 1, 6, and 11 post eclosion were constructed. We identified 755 and 865 differentially expressed genes in the comparisons of T6 (testes on day 6) vs...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38525338/association-between-organophosphate-flame-retardant-exposure-and-lipid-metabolism-data-from-the-2013-2014-national-health-and-nutrition-examination-survey
#11
JOURNAL ARTICLE
Fu-Jen Cheng, Kai-Fan Tsai, Kuo-Chen Huang, Chia-Te Kung, Wan-Ting Huang, Huey-Ling You, Shau-Hsuan Li, Chin-Chou Wang, Wen-Chin Lee, Hsiu-Yung Pan
Organophosphate flame retardants (OPFRs) are emerging environmental pollutants that can be detected in water, dust, and biological organisms. Certain OPFRs can disrupt lipid metabolism in animal models and cell lines. However, the effects of OPFRs on human lipid metabolism remain unclear. We included 1,580 participants (≥20 years) from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) to explore the relationship between OPFR exposure and lipid metabolism biomarkers. After adjusting for confounding factors, results showed that one-unit increases in the log levels of diphenyl phosphate (DPhP) (regression coefficient = -5...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38524448/development-of-high-performance-coconut-oil-based-rigid-polyurethane-urea-foam-a-novel-sequential-amidation-and-prepolymerization-process
#12
JOURNAL ARTICLE
Louell Nikki A Hipulan, Roger G Dingcong, Dave Joseph E Estrada, Gerard G Dumancas, John Christian S Bondaug, Arnold C Alguno, Hernando P Bacosa, Roberto M Malaluan, Arnold A Lubguban
The utilization of coconut diethanolamide ( p -CDEA) as a substitute polyol for petroleum-based polyol in fully biobased rigid polyurethane-urea foam (RPUAF) faces challenges due to its short chain and limited cross-linking capability. This leads to compromised cell wall resistance during foam expansion, resulting in significant ruptured cells and adverse effects on mechanical and thermal properties. To address this, a novel sequential amidation-prepolymerization route was employed on coconut oil, yielding a hydroxyl-terminated poly(urethane-urea) prepolymer polyol (COPUAP)...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38523608/the-efficacy-and-safety-of-novel-antiepileptic-drugs-in-treatment-of-epilepsy-of-patients-with-brain-tumors
#13
REVIEW
Weiwei Zhai, Qiaoling Yu, Huizhen Wu
OBJECTIVE: This meta-analysis aimed to assess the effectiveness and safety of novel antiepileptic drugs (AEDs) in treating epilepsy in patients with brain tumors (BTRE). METHODS: A search was conducted on PubMed, EMBASE, Web of Science, and the Cochrane Library from inception to February 2023, with English language restriction. RESULTS: In this meta-analysis, 18 clinical trials involving 755 BTRE patients were included to assess the efficacy and safety of novel AEDs in BTRE treatment...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38521899/epidemiology-of-congenital-polydactyly-and-syndactyly-in-hunan-province-china
#14
JOURNAL ARTICLE
Xu Zhou, Ting Li, Haiyan Kuang, Ying Zhou, Donghua Xie, Jian He, Juan Xiao, Chanchan Chen, Yurong Jiang, Junqun Fang, Hua Wang
OBJECTIVE: To describe the prevalence and epidemiology of congenital polydactyly and syndactyly in Hunan Province, China, 2016-2020. METHODS: Data were obtained from the Birth Defects Surveillance System in Hunan Province, China, 2016-2020. Prevalence of birth defects (polydactyly or syndactyly) is the number of cases per 1000 births (unit: ‰). Prevalence and 95% confidence intervals (CI) were calculated by the log-binomial method. Chi-square trend tests (χ2 trend ) were used to determine trends in prevalence by year...
March 23, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38519901/comparison-of-asl-and-dsc-perfusion-methods-in-the-evaluation-of-response-to-treatment-in-patients-with-a-history-of-treatment-for-malignant-brain-tumor
#15
JOURNAL ARTICLE
Ezgi Suat Bayraktar, Gokhan Duygulu, Yusuf Kenan Çetinoğlu, Mustafa Fazıl Gelal, Melda Apaydın, Hülya Ellidokuz
OBJECTIVE: Perfusion MRI is of great benefit in the post-treatment evaluation of brain tumors. Interestingly, dynamic susceptibility contrast-enhanced (DSC) perfusion has taken its place in routine examination for this purpose. The use of arterial spin labeling (ASL), a perfusion technique that does not require exogenous contrast material injection, has gained popularity in recent years. The aim of the study was to compare two different perfusion techniques, ASL and DSC, using qualitative and quantitative measurements and to investigate the diagnostic effectiveness of both...
March 22, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38519717/identification-of-four-novel-mutations-in-vsp13a-in-iranian-patients-with-chorea-acanthocytosis-chac
#16
JOURNAL ARTICLE
Vadieh Ghodsinezhad, Abdoreza Ghoreishi, Mohammad Rohani, Mahdi Dadfar, Akbar Mohammadzadeh, Ali Rostami, Hamzeh Rahimi
Chorea-acanthocytosis (ChAc) is a rare autosomal recessive neurodegenerative disorder characterized by a variety of involuntary movements, predominantly chorea, and the presence of acanthocytosis in peripheral blood smears. ChAc is caused by mutations in the vacuolar protein sorting-associated protein 13A (VPS13A) gene. The aim of the present study was to conduct a clinical and genetic analysis of five patients with suspected ChAc in Iran. This study included five patients who were referred to the genetic department of the Endocrinology and Metabolism Research Institute between 2020 and 2022, with a suspicion of ChAc...
March 22, 2024: Molecular Genetics and Genomics: MGG
https://read.qxmd.com/read/38518592/immune-related-adverse-events-associated-with-first-line-immune-checkpoint-inhibitors-for-metastatic-renal-cell-carcinoma-a-systematic-review-and-network-meta-analysis
#17
REVIEW
Shan Wang, Hongwei Lv, Jing Yu, Miao Chen
BACKGROUND: In the realm of metastatic renal cell carcinoma (mRCC), the introduction of immune checkpoint inhibitors (ICIs) has revolutionized treatment paradigms. Despite their effectiveness, the comprehensive safety profile of these therapies remains inadequately explored. This network meta-analysis aims to comparing the safety profiles of ICI-based treatments in mRCC, offering vital insights that could lead to the optimization of treatment strategies and improvement of patient care...
March 21, 2024: International Immunopharmacology
https://read.qxmd.com/read/38516313/missense-mutation-of-angiotensin-converting-enzyme-gene-in-an-alzheimer-s-disease-patient-a-case-report
#18
Mingyue He, Fan Zhang, Jing Qi, Wei Zhang
Alzheimer's disease (AD) is the most common type of cognitive impairment in the elderly. In this report, we presented a case of a 52-year-old woman with rapid disease progression within 6 months. She was diagnosed with mild dementia according to the clinical symptoms and neuropsychological assessment results. Based on the results of neuropathological proteins in cerebrospinal fluid, cranial magnetic resonance imaging, and positron emission tomography/computed tomography, the patient showed the presence of β amyloid deposition, pathologic tau along with neurodegeneration [A+T+(N+)], indicative of AD...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38516133/spotlight-on-eltrombopag-concentration-in-pediatric-immune-thrombocytopenia-a-single-center-observational-study-in-china
#19
JOURNAL ARTICLE
Shuyue Dong, Zhifa Wang, Nan Wang, Jingyao Ma, Jinxi Meng, Yixin Sun, Xiaoling Cheng, Runhui Wu
IMPORTANCE: Eltrombopag has been recommended for pediatric immune thrombocytopenia (ITP). Response and adverse drug reactions (ADRs) varied widely between individuals, even at the same dose of eltrombopag. The appropriate eltrombopag concentration in ITP has not been reported. OBJECTIVE: This study aims to explore the appropriate eltrombopag concentration in pediatric ITP. METHODS: This was a single-center, prospective cohort study. Children diagnosed with refractory persistent/chronic ITP and platelet count < 30×109 /L were treated with eltrombopag and followed up for at least 2 months...
March 2024: Pediatric Investigation
https://read.qxmd.com/read/38513180/effects-of-isocaloric-resistance-aerobic-and-concurrent-exercise-on-excess-postexercise-oxygen-consumption-in-older-adults
#20
JOURNAL ARTICLE
Rui Pilon, Lenifran Matos-Santos, Marcelle Passeri Matlez, Guilherme Rodrigues, Felipe Amorim, Eduardo Lattari, Paulo Farinatti, Walace Monteiro
Pilon, R, Matos-Santos, L, Matlez, MP, Rodrigues, G, Amorim, F, Lattari, E, Farinatti, P, and Monteiro, W. Effects of isocaloric resistance, aerobic, and concurrent exercise on excess postexercise oxygen consumption in older adults. J Strength Cond Res 38(4): 755-761, 2024-Excess postexercise oxygen consumption (EPOC) is a major determinant of exercise-related caloric expenditure and metabolic adaptations. Exercise modality may influence the EPOC, but this issue has not been investigated in older adults. This study compared the EPOC after isocaloric bouts of continuous aerobic exercise (AE), resistance exercise (RE), and concurrent exercise (CE) in older individuals...
April 1, 2024: Journal of Strength and Conditioning Research
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