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https://www.readbyqxmd.com/read/28212183/cxcl12-cxcr4-signaling-contributes-to-the-pathogenesis-of-opioid-tolerance-a-translational-study
#1
Chih-Peng Lin, Kai-Hsiang Kang, Huang-Ju Tu, Ming-Yueh Wu, Tzu-Hung Lin, Houng-Chi Liou, Wei-Zen Sun, Wen-Mei Fu
BACKGROUND: Long-term opioid therapy for chronic pain may lead to analgesic tolerance, especially when administered intrathecally, thus preventing adequate pain relief. Discovering drug targets to treat opioid tolerance using a mechanism-based approach targeting opioid-induced neuroinflammation provides new therapeutic opportunities. In this study, we provide translational evidence that CXCL12/CXCR4 signaling contributes to the pathogenesis of opioid tolerance. METHODS: The CXCL12 levels in the cerebrospinal fluid of opioid-tolerant patients were compared with those of opioid-naive subjects...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28206909/a-highly-pathogenic-avian-derived-influenza-virus-h5n1-with-2009-pandemic-h1n1-internal-genes-demonstrates-increased-replication-and-transmission-in-pigs
#2
Eugenio J Abente, Pravina Kitikoon, Kelly M Lager, Phillip C Gauger, Tavis K Anderson, Amy L Vincent
This study investigated the pathogenicity and transmissibility of a reverse-genetics-derived highly pathogenic avian influenza (HPAI) H5N1 lineage influenza A virus that was isolated from a human, A/Iraq/755/06. We also examined surface gene reassortant viruses composed of the haemagglutinin and neuraminidase from A/Iraq/755/06 and the internal genes of a 2009 pandemic H1N1 virus, A/New York/18/2009 (2Iraq/06 : 6NY/09 H5N1), and haemagglutinin and neuraminidase from A/New York/18/2009 with the internal genes of A/Iraq/755/06 (2NY/09 : 6Iraq/06 H1N1)...
January 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28193032/transcription-factor-response-elements-on-tip-a-sensitive-approach-for-large-scale-endogenous-transcription-factor-quantitative-identification
#3
Wenhao Shi, Kai Li, Lei Song, Mingwei Liu, Yunzhi Wang, Wanlin Liu, Xia Xia, Zhaoyu Qin, Bei Zhen, Yi Wang, Fuchu He, Jun Qin, Chen Ding
The ability to map endogenous transcription factors (TFs) DNA binding activity at the proteome scale will greatly enhance our understanding of various biological processes. Here we report a highly sensitive, rapid, and high-throughput approach, transcription factor response elements on tip-mass spectrometry (TOT-MS), that allows for quantitative measurement of endogenous TFs. A total of 150 TFs from 1 μg of nuclear extracts can be quantified with single shot mass spectrometry detection in 1 h of machine time...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28182642/prophylactic-mesh-placement-for-the-prevention-of-parastomal-hernias-the-presto-systematic-review-and-meta-analysis
#4
Frank Pianka, Pascal Probst, Anne-Valerie Keller, Daniel Saure, Kathrin Grummich, Markus W Büchler, Markus K Diener
BACKGROUND: Parastomal hernia (PH) is the most common complication after ostomy formation. Prophylactic mesh placement may be effective in reducing the rate of PH at the stoma site. The aims of this systematic review were to summarize the evidence with regard to the safety and effectiveness in comparison with the standard procedure without mesh placement and to identify important risk constellations. METHOD: A systematic literature search was performed in PubMed, EMBASE and the Cochrane library with no language or date restrictions...
2017: PloS One
https://www.readbyqxmd.com/read/28178043/outcomes-of-women-with-high-grade-and-low-grade-advanced-stage-serous-epithelial-ovarian-cancer
#5
Allison Gockley, Alexander Melamed, Amy J Bregar, Joel T Clemmer, Michael Birrer, John O Schorge, Marcela G Del Carmen, J Alejandro Rauh-Hain
OBJECTIVE: To compare outcomes of women with advanced-stage low-grade serous ovarian cancer and high-grade serous ovarian cancer and identify factors associated with survival among patients with advanced-stage low-grade serous ovarian cancer. METHODS: A retrospective study of patients diagnosed with grade 1 or 3, advanced-stage (stage IIIC and IV) serous ovarian cancer between 2003 and 2011 was undertaken using the National Cancer Database, a large administrative database...
February 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28166070/prevalence-of-respiratory-diseases-according-to-spirometry-findings-among-patients-attending-the-spirometry-department-of-dhulikhel-hospital
#6
B K Prajapati, S Pradhan
Background Spirometry is a standard test for screening and evaluation of patients with symptoms of cough and shortness of breath. Despite its easy availability, low cost and ease of performance it has not been widely used in clinical practice in Nepal. Objective To assess the prevalence of respiratory diseases in a regional referral centre in patients referred for spirometry. Method This is a descriptive cross-sectional study including patients referred for spirometry to the spirometry unit of Dhulikhel Hospital, Kathmandu University Hospital from 2014 July to 2015 October...
April 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/28165143/potentially-modifiable-factors-associated-with-physical-activity-in-individuals-with-multiple-sclerosis
#7
Nadia Reider, Amber R Salter, Gary R Cutter, Tuula Tyry, Ruth Ann Marrie
Physical activity levels among persons with multiple sclerosis (MS) are worryingly low. We aimed to identify the factors associated with physical activity for people with MS, with an emphasis on factors that have not been studied previously (bladder and hand dysfunction) and are potentially modifiable. This study was a secondary analysis of data collected in the spring of 2012 during the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry. NARCOMS participants were surveyed regarding smoking using questions from the Behavioral Risk Factor Surveillance Survey; disability using the Patient Determined Disease Steps; fatigue, cognition, spasticity, sensory, bladder, vision and hand function using self-reported Performance Scales; health literacy using the Medical Term Recognition Test; and physical activity using questions from the Health Information National Trends Survey...
February 6, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/28164671/urinary-intestine-fatty-acid-binding-protein-is-associated-with-poor-outcome-of-pneumonia-patients-in-intensive-care-unit
#8
Sai-Wai Ho, Shi-Chuan Chang, Lee-Wei Chen
BACKGROUND: Urinary intestine fatty acid binding protein (U-IFABP) is a biomarker for gut injury. Previous studies showed that enterocyte damage in critically ill patients was common and appeared to be associated with poor prognosis. However, the impact of enterocyte damage on the outcome of critically ill patients with pneumonia has not yet been well investigated. The aim of the study is to evaluate the prognostic value of U-IFABP in critically ill patients with pneumonia. METHODS: A prospective observational study was performed in the intensive care unit (ICU) from September 1, 2013 to April 30, 2014...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28159221/trace-elements-in-early-phase-type-2-diabetes-mellitus-a-population-based-study-the-hunt-study-in-norway
#9
Ailin Falkmo Hansen, Anica Simić, Bjørn Olav Åsvold, Pål Richard Romundstad, Kristian Midthjell, Tore Syversen, Trond Peder Flaten
Differences in trace elements levels between individuals with type 2 diabetes and controls have been reported in several studies in various body fluids and tissues, but results have been inconsistent. In order to examine trace element levels in the early phase of type 2 diabetes, we investigated the association between whole blood levels of 26 trace elements and the prevalence of previously undiagnosed, screening-detected type 2 diabetes. The study was conducted as a case-control study nested within the third survey of the population-based Nord-Trøndelag Health Study (HUNT3 Survey)...
March 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28159129/attitudes-toward-abortion-among-students-at-the-university-of-cape-coast-ghana
#10
Sarah D Rominski, Eugene Darteh, Kwamena Sekyi Dickson, Michelle Munro-Kramer
OBJECTIVES: This study aimed to describe the attitudes toward abortion of Ghanaian University students and to determine factors which are associated with supporting a woman's right to an abortion. METHODS: This cross-sectional survey was administered to residential students at the University of Cape Coast. Participants were posed a series of 26 statements to determine to what extent they were supportive of abortion as a woman's right. An exploratory factor analysis was used to create a scale with the pertinent factors that relate to abortion attitudes and a multivariable linear regression model explored the relationships among significant variables noted during exploratory factor analysis...
March 2017: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/28156175/docosahexaenoic-acid-mediated-targeted-and-sustained-brain-delivery-of-curcumin-microemulsion
#11
Rajshree L Shinde, Padma V Devarajan
We disclose microemulsions (ME) of curcumin (CUR) with docosahexaenoic acid (DHA)-rich oil (CUR DHA ME) for targeted delivery to the brain. MEs of CUR (5 mg/mL) with and without DHA-rich oil (CUR Capmul ME) suitable for intravenous and intranasal administration exhibited negative zeta potential, globule size  <20 nm and good stability. Following intravenous delivery MEs exhibited high brain concentration with CUR DHA ME exhibiting a 2.8-fold higher Cmax than CUR solution. Furthermore, high and sustained concentration was demonstrated even at 24 h, which was 8- and 2-fold higher than CUR solution and CUR Capmul ME, respectively...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28150957/model-flexibility-analysis-does-not-measure-the-persuasiveness-of-a-fit
#12
Nathan J Evans, Zachary L Howard, Andrew Heathcote, Scott D Brown
Recently, Veksler, Myers, and Gluck (2015) proposed model flexibility analysis as a method that "aids model evaluation by providing a metric for gauging the persuasiveness of a given fit" (p. 755) Model flexibility analysis measures the complexity of a model in terms of the proportion of all possible data patterns it can predict. We show that this measure does not provide a reliable way to gauge complexity, which prevents model flexibility analysis from fulfilling either of the 2 aims outlined by Veksler et al...
February 2, 2017: Psychological Review
https://www.readbyqxmd.com/read/28144967/oncological-outcomes-after-radical-prostatectomy-for-high-risk-prostate-cancer-based-on-new-gleason-grouping-system-a-validation-study-from-university-of-southern-california-with-3-755-cases
#13
Hooman Djaladat, Erfan Amini, Weichen Xu, Jie Cai, Siamak Daneshmand, Gary Lieskovsky
BACKGROUNDS: To assess the prognostic value of new Gleason grade grouping system in high-risk prostate cancer patients, we compared oncological outcomes after radical prostatectomy for patients with Gleason score 8 versus 9-10. METHODS: Between 1987 and 2008, 3,755 men underwent radical prostatectomy with curative intent at University of Southern California. Patients who had Gleason score 8-10 at final histopathological evaluation (pT2-4N0) were included in this study...
February 1, 2017: Prostate
https://www.readbyqxmd.com/read/28139230/comparison-of-operative-outcomes-between-surgical-gastrostomy-and-percutaneous-endoscopic-gastrostomy-in-infants
#14
Shin Miyata, Fanglong Dong, Olga Lebedevskiy, Hanna Park, Nam Nguyen
PURPOSE: Safety profile of different gastrostomy procedures in small children has not been well studied. This study was conducted to investigate whether complication and mortality rates differ between surgical gastrostomy (G-tube) and percutaneous endoscopic gastrostomy (PEG) in infants and neonates. METHODS: In this retrospective study utilizing the Kids' Inpatient Database, all infants who underwent either G-tube or PEG as a sole procedure were identified. Variables included age, gender, race, presence of neurological impairment, prematurity, complex chronic condition, and severity of illness/risk of mortality subclasses...
January 23, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28138180/histopathological-pattern-of-benign-endoscopic-gastric-biopsies-in-western-saudi-arabia-a-review-of-1236-cases
#15
Zeinab Moustafa Elsawaf, Abdulkader Mohammed Albasri, Akbar Shah Hussainy, Ahmed Safar Alhujaily
OBJECTIVE: To determine the histopathological pattern of gastritis and benign gastric diseases in western Saudi Arabia. METHODS: TThis retrospective histopathology-based study was conducted in a tertiary care hospital in Madinah, Saudi Arabia, and comprised medical records of all patients who were diagnosed to have benign gastric diseases from January 2006 to December 2015.SPSS 19 was used for data analysis. RESULTS: Of the 1,236 patients, 669(54...
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28135370/patient-satisfaction-reporting-after-total-hip-arthroplasty-a-systematic-review
#16
Cynthia A Kahlenberg, Benedict U Nwachukwu, William W Schairer, Michael E Steinhaus, Michael B Cross
This review evaluated the quality of patient satisfaction reporting after total hip arthroplasty. The initial search of the MEDLINE database yielded 755 studies. Twenty-four met the inclusion criteria. Most studies provided level III or IV evidence (n=15, 62.5%). The most common method used to assess satisfaction was the 10-point visual analog scale (7 studies, 29.2%), followed by an ordinal satisfaction scale (6 studies, 25.0%). The quality of evidence was poor, and the methods used to assess satisfaction were not standardized...
January 30, 2017: Orthopedics
https://www.readbyqxmd.com/read/28135194/validation-of-a-novel-claims-based-stroke-severity-index-in-patients-with-intracerebral-hemorrhage
#17
Ling-Chien Hung, Sheng-Feng Sung, Cheng-Yang Hsieh, Ya-Han Hu, Huey-Juan Lin, Yu-Wei Chen, Yea-Huei Kao Yang, Sue-Jane Lin
BACKGROUND: Stroke severity is an important outcome predictor for intracerebral hemorrhage (ICH) but is typically unavailable in administrative claims data. We validated a claims-based stroke severity index (SSI) in patients with ICH in Taiwan. METHODS: Consecutive ICH patients from hospital-based stroke registries were linked with a nationwide claims database. Stroke severity, assessed using the National Institutes of Health Stroke Scale (NIHSS), and functional outcomes, assessed using the modified Rankin Scale (mRS), were obtained from the registries...
January 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28131532/high-frequency-spectral-changes-induced-by-single-pulse-electric-stimulation-comparison-between-physiologic-and-pathologic-networks
#18
Mihai Dragos Mălîia, Cristian Donos, Andrei Barborica, Ioana Mindruta, Irina Popa, Mirela Ene, Sándor Beniczky
OBJECTIVE: To investigate functional coupling between brain networks using spectral changes induced by single-pulse electric stimulation (SPES). METHOD: We analyzed 20 patients with focal epilepsy, implanted with depth electrodes. SPES was applied to each pair of adjacent contacts, and responses were recorded from all other contacts. The mean response amplitude value was quantified in three time-periods after stimulation (10-60, 60-255, 255-500ms) for three frequency-ranges (Gamma, Ripples, Fast-Ripples), and compared to baseline...
December 28, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28125633/new-insights-into-the-complex-relationship-between-weight-and-maturity-of-burgundy-truffles-tuber-aestivum
#19
Ulf Büntgen, István Bagi, Oszkár Fekete, Virginie Molinier, Martina Peter, Richard Splivallo, Maryam Vahdatzadeh, Franck Richard, Claude Murat, Willy Tegel, Ulrich Stobbe, Fernando Martínez-Peña, Ludger Sproll, Lisa Hülsmann, Daniel Nievergelt, Barbara Meier, Simon Egli
Despite an increasing demand for Burgundy truffles (Tuber aestivum), gaps remain in our understanding of the fungus' overall lifecycle and ecology. Here, we compile evidence from three independent surveys in Hungary and Switzerland. First, we measured the weight and maturity of 2,656 T. aestivum fruit bodies from a three-day harvest in August 2014 in a highly productive orchard in Hungary. All specimens ranging between 2 and 755 g were almost evenly distributed through five maturation classes. Then, we measured the weight and maturity of another 4,795 T...
2017: PloS One
https://www.readbyqxmd.com/read/28125302/psychological-distress-among-re-education-through-labour-camp-detainees-in-guangxi-autonomous-region-china
#20
Lorraine Yap, Su Shu, Lei Zhang, Wei Liu, Yi Chen, Zunyou Wu, Jianghong Li, Handan Wand, Basil Donovan, Tony Butler
BACKGROUND: There is currently no information about the prevalence of, and factors contributing to psychological distress experienced by re-education through labour camp detainees in China. METHODS: A cross-sectional face-to-face survey was conducted in three labour camps in Guangxi, China. The questionnaire covered socio-demographic characteristics; sexually transmissible infections (STIs); drug use; psychological distress (K-10); and health service usage and access inside the labour camps...
January 26, 2017: Journal of Mental Health
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