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https://www.readbyqxmd.com/read/28821734/transcriptional-transitions-in-alphonso-mango-mangifera-indica-l-during-fruit-development-and-ripening-explain-its-distinct-aroma-and-shelf-life-characteristics
#1
Ashish B Deshpande, Krishanpal Anamika, Vineet Jha, Hemangi G Chidley, Pranjali S Oak, Narendra Y Kadoo, Keshav H Pujari, Ashok P Giri, Vidya S Gupta
Alphonso is known as the "King of mangos" due to its unique flavor, attractive color, low fiber pulp and long shelf life. We analyzed the transcriptome of Alphonso mango through Illumina sequencing from seven stages of fruit development and ripening as well as flower. Total transcriptome data from these stages ranged between 65 and 143 Mb. Importantly, 20,755 unique transcripts were annotated and 4,611 were assigned enzyme commission numbers, which encoded 142 biological pathways. These included ethylene and flavor related secondary metabolite biosynthesis pathways, as well as those involved in metabolism of starch, sucrose, amino acids and fatty acids...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28820885/diagnostic-efficacy-of-noninvasive-liver-fibrosis-indexes-in-predicting-portal-hypertension-in-patients-with-cirrhosis
#2
Le Wang, Yuemin Feng, Xiaowen Ma, Guangchuan Wang, Hao Wu, Xiaoyu Xie, Chunqing Zhang, Qiang Zhu
BACKGROUND: Recent data suggest that noninvasive liver fibrosis indexes could be useful for predicting esophageal varices (EV) in cirrhotic patients. However, thus far, the diagnostic efficacy of these indexes in predicting portal hypertension (PH) in cirrhotic patients has been poorly evaluated. AIMS: To evaluate the diagnostic efficacy of noninvasive liver fibrosis indexes in the diagnosis of PH. METHODS: A total of 238 cirrhotic patients underwent hepatic venous pressure gradient (HVPG) evaluation and relevant serum tests to analyze the variables associated with PH grade...
2017: PloS One
https://www.readbyqxmd.com/read/28818551/adverse-pathology-after-neoadjuvant-chemotherapy-and-radical-cystectomy-the-role-of-adjuvant-chemotherapy
#3
William P Parker, Elizabeth B Habermann, Courtney N Day, Harras B Zaid, Igor Frank, R Houston Thompson, Matthew K Tollefson, Stephen A Boorjian, Lance C Pagliaro, R Jeffrey Karnes
BACKGROUND: The current guidelines do not recommend adjuvant chemotherapy (AC) for patients with adverse pathologic findings after neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) for bladder cancer. We sought to evaluate the association of AC with overall survival (OS) in these patients. MATERIALS AND METHODS: The National Cancer Database was used to identify patients with adverse pathologic findings (ypT3N0, ypT4N0, or ypTanyN1-N3) after NAC and RC for bladder cancer from 2006 to 2012...
July 22, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28818212/national-trends-in-hospitalizations-for-venous-thromboembolism
#4
Anand Brahmandam, Marwan S Abougergi, Cassius Iyad Ochoa Chaar
OBJECTIVE: The management of venous thromboembolism (VTE) has evolved during the last decade. This study sheds light on the national trends in hospital admissions, outcomes, and economic burden for VTE. METHODS: The National Inpatient Sample (NIS) was reviewed between 2003 and 2013 for hospitalizations for VTE, defined as admissions with a principal diagnosis of deep venous thrombosis (DVT) or pulmonary embolism (PE). Outcomes measured were incidence, inpatient mortality, rates of interventions, hospital length of stay (LOS), and charges...
September 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28809990/topical-desoximetasone-0-25-spray-and-its-vehicle-have-little-potential-for-irritation-or-sensitization
#5
Anish Nadkarni, Mohammed D Saleem, Steven R Feldman
<p>BACKGROUND: Topical corticosteroids are the most common dermatologic medications and are available in numerous different vehicles. Adherence is limited by traditional vehicles because they are messy and time consuming to apply. The preferred spray formulations have the advantage of being applied with ease, resulting in improved adherence and subsequently improved psoriasis. One limitation of topical treatments, especially spray vehicles, is the potential for irritation and sensitization.</p> <p>OBJECTIVE: To evaluate the irritation and sensitization potential of topical desoximetasone spray formulation...
August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28809634/-wear-and-roughness-of-bearing-surface-in-retrieved-polyethylene-bicon-plus-cups
#6
M Ranuša, J Gallo, M Hobza, M Vrbka, D Nečas, M Hartl
PURPOSE OF THE STUDY By 7th December 2016, 4,755 Bicon-Plus cups in total were implanted in the Czech Republic. Some of them have been continuously re-operated, while the most frequent reason of failure is polyethylene wear and aseptic loosening. The present study is focused on surface analysis of retrieved polyethylene Bicon-Plus cups and the determination of the roughness of their bearing surfaces. MATERIAL AND METHODS In this study, we had 13 high molecular weight polyethylene cups with the average time in situ of 8...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28802528/how-young-is-too-young-in-breast-cancer-young-breast-cancer-is-not-a-unique-biological-subtype
#7
Jianfei Fu, Lunpo Wu, Wei Fu, Yinuo Tan, Tiantian Xu, Zhongwu Hong, Fan Wang, Shuguang Li
BACKGROUND: There is no uniformly adopted cutoff value to define "young patients" with breast cancer. This study was designed to determine an optimal cutoff value, to investigate prognostic factors and to explore gene expression profiles of young female breast cancer. MATERIALS AND METHODS: The Surveillance, Epidemiology, and End Results database was examined to identify cases of female breast cancer diagnosed between 2000 and 2007. The optimal cutoff value for young age was determined using the X-tile program (Yale University, version 3...
June 8, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28801424/a-cost-effectiveness-comparison-of-the-nice-2015-and-who-2013-diagnostic-criteria-for-women-with-gestational-diabetes-with-and-without-risk-factors
#8
Paul Brian Jacklin, Michael Ja Maresh, Chris C Patterson, Katharine P Stanley, Anne Dornhorst, Shona Burman-Roy, Rudy W Bilous
OBJECTIVES: To compare the cost-effectiveness (CE) of the National Institute for Health and Care Excellence (NICE) 2015 and the WHO 2013 diagnostic thresholds for gestational diabetes mellitus (GDM). SETTING: The analysis was from the perspective of the National Health Service in England and Wales. PARTICIPANTS: 6221 patients from four of the Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) study centres (two UK, two Australian), 6308 patients from the Atlantic Diabetes in Pregnancy study and 12 755 patients from UK clinical practice...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799748/exceptionally-high-piezoelectric-coefficient-and-low-strain-hysteresis-in-grain-oriented-ba-ca-ti-zr-o3-through-integrating-crystallographic-texture-and-domain-engineering
#9
Yingchun Liu, Yunfei Chang, Fei Li, Bin Yang, Yuan Sun, Jie Wu, Shantao Zhang, Ruixue Wang, Wenwu Cao
Both low strain hysteresis and high piezoelectric performance are required for practical applications in precisely controlled piezoelectric devices and systems. Unfortunately, enhanced piezoelectric properties were usually obtained with the presence of a large strain hysteresis in BaTiO3 (BT)-based piezoceramics. In this work, we propose to integrate crystallographic texturing and domain engineering strategies into BT-based ceramics to resolve this challenge. [001]c grain-oriented (Ba0.94Ca0.06)(Ti0.95Zr0.05)O3 (BCTZ) ceramics with a texture degree as high as 98...
August 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28798814/editorial-childhood-cancer-in-sub-saharan-africa
#10
EDITORIAL
Donald Maxwell Parkin, Cristina Stefan
Measurement of incidence rates of childhood cancer in Africa is difficult. The study 'Cancer of Childhood in sub Saharan Africa' [Stefan C, Bray F, Ferlay J, Parkin DM and Liu B (2017) Cancer of Childhood in sub-Saharan Africaecancer11(755)] brings together results from 16 population-based registries which, as members of the African Cancer Registry Network (AFCRN), have been evaluated as achieving adequate coverage of their target population. The cancers are classified according to the third revision of the International Classification of Childhood Cancer (ICCC-3) and recorded rates in Africa are compared with those in childhood populations in the UK, France, and the USA...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28798483/continental-scale-variability-of-foliar-nitrogen-and-carbon-isotopes-in-populus-balsamifera-and-their-relationships-with-climate
#11
Andrew J Elmore, Joseph M Craine, David M Nelson, Steven M Guinn
Variation across climate gradients in the isotopic composition of nitrogen (N) and carbon (C) in foliar tissues has the potential to reveal ecological processes related to N and water availability. However, it has been a challenge to separate spatial patterns related to direct effects of climate from effects that manifest indirectly through species turnover across climate gradients. Here we compare variation along environmental gradients in foliar N isotope (δ(15)N) and C isotopic discrimination (Δ(13)C) measured in 755 specimens of a single widely distributed tree species, Populus balsamifera, with variation represented in global databases of foliar isotopes...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797125/accuracy-and-reproducibility-of-mouse-cortical-bone-microporosity-as-quantified-by-desktop-microcomputed-tomography
#12
Haniyeh Hemmatian, Michaël R Laurent, Samaneh Ghazanfari, Dirk Vanderschueren, Astrid D Bakker, Jenneke Klein-Nulend, G Harry van Lenthe
Bone's microporosity plays important roles in bone biology and bone mechanical quality. In this study, we explored the accuracy and reproducibility of nondestructive desktop μCT for 3D visualization and subsequent morphometric analysis of mouse cortical bone microporosity including the vascular canal network and osteocyte lacunae. The accuracy of measurements was evaluated in five murine fibula using confocal laser scanning microscopy (CLSM) in conjunction with Fluorescein isothiocyanate (FITC) staining as the reference method...
2017: PloS One
https://www.readbyqxmd.com/read/28796837/whole-genome-sequence-of-two-rathayibacter-toxicus-strains-reveals-a-tunicamycin-biosynthetic-cluster-similar-to-streptomyces-chartreusis
#13
Aaron J Sechler, Matthew A Tancos, David J Schneider, Jonas G King, Christine M Fennessey, Brenda K Schroeder, Timothy D Murray, Douglas G Luster, William L Schneider, Elizabeth E Rogers
Rathayibacter toxicus is a forage grass associated Gram-positive bacterium of major concern to food safety and agriculture. This species is listed by USDA-APHIS as a plant pathogen select agent because it produces a tunicamycin-like toxin that is lethal to livestock and may be vectored by nematode species native to the U.S. The complete genomes of two strains of R. toxicus, including the type strain FH-79, were sequenced and analyzed in comparison with all available, complete R. toxicus genomes. Genome sizes ranged from 2,343,780 to 2,394,755 nucleotides, with 2079 to 2137 predicted open reading frames; all four strains showed remarkable synteny over nearly the entire genome, with only a small transposed region...
2017: PloS One
https://www.readbyqxmd.com/read/28795030/comparison-of-the-outcomes-between-surgical-aortic-valve-replacement-and-transcatheter-aortic-valve-replacement-in-patients-aged-above-80
#14
Jeong-Woo Lee, Jihoon Kim, Sung-Ho Jung, Cheol Hyun Chung, Jae Won Lee
BACKGROUND: Transcatheter aortic valve replacement (TAVR) has been suggested as a less invasive treatment for high-risk patients with aortic valve disease. In this study, we compared the outcomes of conventional surgical aortic valve replacement (AVR) and TAVR in elderly patients aged over 80. METHODS: A total of 108 patients aged 80 years or older who underwent isolated AVR (n=35) or TAVR (n=73) from 2010 through 2015 at Asan Medical Center were identified. Early and late clinical outcomes, including echocardiographic findings, were evaluated in both groups...
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28789774/maternal-childhood-cardiometabolic-risk-factors-and-pregnancy-complications
#15
Maeve Wallace, Lydia Bazzano, Wei Chen, Emily Harville
PURPOSE: The influence of childhood health on later-life health outcomes is increasingly hypothesized but rarely tested. We examined the relationship between cardiometabolic indicators in childhood and risk of pregnancy-induced hypertension, preeclampsia, and gestational diabetes. METHODS: Childhood measurements from 755 women in the Bogalusa Heart Study included body mass index, systolic and diastolic blood pressure (SBP and DBP), low- and high-density lipoprotein cholesterol, total cholesterol, triglycerides, insulin, and glucose...
July 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28781819/progression-free-survival-of-first-line-treatment-with-molecular-targeted-therapy-may-be-a-meaningful-intermediate-endpoint-for-overall-survival-in-patients-with-metastatic-renal-cell-carcinoma
#16
Nobuki Furubayashi, Takahito Negishi, Takuya Yamashita, Shuhei Kusano, Kenichi Taguchi, Mototsugu Shimokawa, Motonobu Nakamura
The aim of the present study was to investigate the association between clinical parameters and the overall survival (OS) of Japanese patients with metastatic renal cell carcinoma (mRCC). The medical records of 59 consecutive mRCC patients receiving molecular-targeted therapy were retrospectively assessed. Kaplan-Meier and log-rank analyses were used to evaluate the progression-free survival (PFS) and OS, and a multivariate Cox proportional hazard model was used to analyze the clinical parameters for their prognostic relevance...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28776242/neonatal-infant-and-under-5-mortality-and-morbidity-burden-in-the-eastern-mediterranean-region-findings-from-the-global-burden-of-disease-2015-study
#17
Ali H Mokdad
OBJECTIVES: Although substantial reductions in under-5 mortality have been observed during the past 35 years, progress in the Eastern Mediterranean Region (EMR) has been uneven. This paper provides an overview of child mortality and morbidity in the EMR based on the Global Burden of Disease (GBD) study. METHODS: We used GBD 2015 study results to explore under-5 mortality and morbidity in EMR countries. RESULTS: In 2015, 755,844 (95% uncertainty interval (UI) 712,064-801,565) children under 5 died in the EMR...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28774077/well-dispersed-co-coo-c-nanospheres-with-tunable-morphology-as-high-performance-anodes-for-lithium-ion-batteries
#18
Bingqing Xu, Jingwei Li, Rujun Chen, Yuanhua Lin, Cewen Nan, Yang Shen
Well-dispersed Co/CoO/C nanospheres have been designed and constructed through a facile electrospinning method with a strategy controlling the morphology of nanocomposites via adjusting the pre-oxidized and heat treatments. Scanning electron microscopy results reveal that the as-synthesized sample pre-oxidized at 275 °C shows better spherical morphology with a diameter of around 300 nm without conspicuous agglomeration. X-ray diffraction analysis confirms the coexistence of cobalt and cobalt monoxide in the sample...
November 24, 2016: Materials
https://www.readbyqxmd.com/read/28771487/cardiorespiratory-dynamics-measured-from-continuous-ecg-monitoring-improves-detection-of-deterioration-in-acute-care-patients-a-retrospective-cohort-study
#19
Travis J Moss, Matthew T Clark, James Forrest Calland, Kyle B Enfield, John D Voss, Douglas E Lake, J Randall Moorman
BACKGROUND: Charted vital signs and laboratory results represent intermittent samples of a patient's dynamic physiologic state and have been used to calculate early warning scores to identify patients at risk of clinical deterioration. We hypothesized that the addition of cardiorespiratory dynamics measured from continuous electrocardiography (ECG) monitoring to intermittently sampled data improves the predictive validity of models trained to detect clinical deterioration prior to intensive care unit (ICU) transfer or unanticipated death...
2017: PloS One
https://www.readbyqxmd.com/read/28764620/the-australian-snakebite-project-2005-2015-asp-20
#20
MULTICENTER STUDY
Christopher I Johnston, Nicole M Ryan, Colin B Page, Nicholas A Buckley, Simon Ga Brown, Margaret A O'Leary, Geoffrey K Isbister
OBJECTIVE: To describe the epidemiology, treatment and adverse events after snakebite in Australia. DESIGN: Prospective, multicentre study of data on patients with snakebites recruited to the Australian Snakebite Project (2005-2015) and data from the National Coronial Information System. Setting, participants: Patients presenting to Australian hospitals with suspected or confirmed snakebites from July 2005 to June 2015 and consenting to participation. MAIN OUTCOME MEASURES: Demographic data, circumstances of bites, clinical effects of envenoming, results of laboratory investigations and snake venom detection kit (SVDK) testing, antivenom treatment and adverse reactions, time to discharge, deaths...
August 7, 2017: Medical Journal of Australia
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