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https://www.readbyqxmd.com/read/29243737/clinical-outcome-of-descemet-stripping-automated-endothelial-keratoplasty-in-18-cases-with-iridocorneal-endothelial-syndrome
#1
M Ao, Y Feng, G Xiao, Y Xu, J Hong
PurposeTo evaluate the clinical outcome of Descemet stripping automated endothelial keratoplasty (DSAEK) in eyes with iridocorneal endothelial (ICE) syndrome.Patients and methodsA retrospective case series study was conducted. Eighteen consecutive Chinese patients with 20 DSAEK grafts were enrolled. Participants were evaluated by anterior segment optical coherence tomography and confocal microscopy. Postoperative complications, graft survival, endothelial cell counts, corneal thickness, and anterior chamber depth were analysed...
December 15, 2017: Eye
https://www.readbyqxmd.com/read/29237169/outer-retina-and-choroidal-thickness-in-intermediate-age-related-macular-degeneration-reticular-pseudodrusen-findings
#2
Pedro Camacho, Marco Dutra-Medeiros, Diogo Cabral, Rufino Silva
PURPOSE: To evaluate outer retina and choroidal thickness in subjects with intermediate age-related macular degeneration (iAMD) and to describe associations with the presence of reticular pseudodrusen (RPD). METHODS: This was a retrospective, cross-sectional analysis of 157 consecutive eyes (specifically: 62 eyes classified as having RPD and 95 eyes with drusen ≥125 µm). Only cases with digital color fundus photographs, red-free, and infrared, obtained and graded according to the Age-Related Eye Disease Study to define iAMD, were used for this study...
December 14, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29233016/the-association-between-the-metabolic-syndrome-and-metabolic-syndrome-score-and-pulmonary-function-in-non-smoking-adults
#3
Hyun Yoon, Mi Young Gi, Ju Ae Cha, Chan Uk Yoo, Sang Muk Park
OBJECTIVE: This study assessed the association of metabolic syndrome and metabolic syndrome score with the predicted forced vital capacity and predicted forced expiratory volume in 1 s (predicted forced expiratory volume in 1 s) values in Korean non-smoking adults. METHODS: We analysed data obtained from 6684 adults during the 2013-2015 Korean National Health and Nutrition Examination Survey. RESULTS: After adjustment for related variables, metabolic syndrome ( p < 0...
December 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29229723/prospective-study-of-fasting-blood-glucose-and-intracerebral-hemorrhagic-risk
#4
Cheng Jin, Guohong Li, Kathryn M Rexrode, Mahmut E Gurol, Xiaodong Yuan, Ying Hui, Chunyu Ruan, Anand Vaidya, Yanxiu Wang, Shouling Wu, Xiang Gao
BACKGROUND AND PURPOSE: Although diabetes mellitus is an established independent risk factor for ischemic stroke, the association between fasting blood glucose and intracerebral hemorrhage (ICH) is limited and inconsistent. The objective of the current study was to examine the potential impact of long-term fasting blood glucose concentration on subsequent risk of ICH. METHODS: This prospective study included 96 110 participants of the Kailuan study, living in Kailuan community, Tangshan city, China, who were free of cardiovascular diseases and cancer at baseline (2006)...
December 11, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29223768/verbal-learning-and-hippocampal-dysfunction-in-schizophrenia-a-meta-analysis
#5
REVIEW
Mathilde Antoniades, Tabea Schoelera, Joaquim Radua, Isabel Valli, Paul Allen, Matthew J Kempton, Philip McGuire
This meta-analysis summarizes research examining whether deficits in verbal learning are related to bilateral hippocampal volume reductions in patients with or at risk for schizophrenia and in healthy controls. 17 studies with 755 patients with schizophrenia (SCZ), 232 Genetic High Risk (GHR) subjects and 914 healthy controls (HC) were included. Pooled correlation coefficients were calculated between hemisphere (left, right or total) and type of recall (immediate or delayed) for each diagnostic group individually (SCZ, GHR and HC)...
December 6, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29222364/investigating-inpatient-medication-administration-using-the-theory-of-planned-behavior
#6
Joseph W Rogers, Marc Fleming, Joyce Tipton, Angela Ward, Kevin W Garey, Elizabeth P Pitman
PURPOSE: Results of a study to determine behavioral factors that help explain why nurses often do not obtain and administer medications from automated dispensing cabinets (ADCs) "one patient at a time" are reported. METHODS: To investigate nurses' frequent failure to adhere to best-practice standards for ADC use, a 12-item questionnaire developed using information obtained from an elicitation study and a focus group session was e-mailed to 755 nurses at an academic medical center...
December 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29221439/catheter-related-blood-stream-infections-in-hemodialysis-patients-a-prospective-cohort-study
#7
Stephanie Thompson, Natasha Wiebe, Scott Klarenbach, Rick Pelletier, Brenda R Hemmelgarn, John S Gill, Braden J Manns, Marcello Tonelli
BACKGROUND: For people requiring hemodialysis, infectious mortality is independently associated with geographic distance from a nephrologist. We aimed to determine if differential management of catheter-related blood stream infections (CRBSIs) could explain poorer outcomes. METHODS: We prospectively collected data from adults initiating hemodialysis with a central venous catheter between 2005 and 2015 in Alberta, Canada. We collected indicators of CRBSI management (timely catheter removal, relapsing bacteremia); frequency of CRBSIs; hospitalizations; predictors of CRBSIs, and bacteremia...
December 8, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29218911/convergent-downstream-candidate-mechanisms-of-independent-intergenic-polymorphisms-between-co-classified-diseases-implicate-epistasis-among-noncoding-elements
#8
Jiali Han, Jianrong Li, Ikbel Achour, Lorenzo Pesce, Ian Foster, Haiquan Li, Yves A Lussier
Eighty percent of DNA outside protein coding regions was shown biochemically functional by the ENCODE project, enabling studies of their interactions. Studies have since explored how convergent downstream mechanisms arise from independent genetic risks of one complex disease. However, the cross-talk and epistasis between intergenic risks associated with distinct complex diseases have not been comprehensively characterized. Our recent integrative genomic analysis unveiled downstream biological effectors of disease-specific polymorphisms buried in intergenic regions, and we then validated their genetic synergy and antagonism in distinct GWAS...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29214662/airborne-particulate-concentration-during-laser-hair-removal-a-comparison-between-cold-sapphire-with-aqueous-gel-and-cryogen-skin-cooling
#9
Edward V Ross, Gary S Chuang, Arisa E Ortiz, Scott A Davenport
BACKGROUND: High concentrations of sub-micron nanoparticles have been shown to be released during laser hair removal (LHR) procedures. These emissions pose a potential biohazard to healthcare workers that have prolonged exposure to LHR plume. OBJECTIVE: We sought to demonstrate that cold sapphire skin cooling done in contact mode might suppress plume dispersion during LHR. METHODS: A total of 11 patients were recruited for laser hair removal...
December 7, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29200769/treatment-of-melasma-and-post-inflammatory-hyperpigmentation-by-a-picosecond-755-nm-alexandrite-laser-in-asian-patients
#10
Ye Jin Lee, Ho Jeong Shin, Tai-Kyung Noh, Kwang-Ho Choi, Sung-Eun Chang
The picosecond lasers have shown to effectively treat tattoo pigments that are intractable to previous multiple Q-switched (QS) laser treatments. Therefore we hypothesized that a picosecond laser would show better efficacy with minimal adverse events in the treatment of melasma and post-inflammatory hyperpigmentation (PIH) that are difficult to treat with conventional QS lasers. Two patients with melasma and one patient with PIH were treated with a Picosecond 755-nm Alexandrite Laser (Cyanosure, USA). All patients were Korean with skin type IV and no longer responding to QS laser treatments...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29200062/is-compliance-with-surgical-care-improvement-project-cardiac-scip-card-2-measures-for-perioperative-%C3%AE-blockers-associated-with-reduced-incidence-of-mortality-and-cardiovascular-related-critical-quality-indicators-after-noncardiac-surgery
#11
Miklos D Kertai, Mary Cooter, Richard J Pollard, William Buhrman, Solomon Aronson, Joseph P Mathew, Mark Stafford-Smith
BACKGROUND: While continuation of β-blockers (BBs) perioperatively has become a national quality improvement measure, the relationship between BB withdrawal and mortality and cardiovascular-related critical quality indicators has not been studied in a contemporary cohort of patients undergoing noncardiac surgery. METHODS: For this retrospective study, the quality assurance database of a large community-based anesthesiology group practice was used to identify 410,288 surgical cases, 18 years of age or older, who underwent elective or emergent noncardiac surgical procedures between January 1, 2009, and December 31, 2014...
November 30, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29198274/fifty-years-of-prefrontal-cortex-research-impact-on-assessment
#12
Paul W Burgess, Donald T Stuss
Our knowledge of the functions of the prefrontal cortex, often called executive, supervisory, or control, has been transformed over the past 50 years. After operationally defining terms for clarification, we review the impact of advances in functional, structural, and theoretical levels of understanding upon neuropsychological assessment practice as a means of identifying 11 principles/challenges relating to assessment of executive function. Three of these were already known 50 years ago, and 8 have been confirmed or emerged since...
October 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29191210/new-clues-to-the-nature-of-immunoglobulin-g4-related-disease-a-retrospective-japanese-multicenter-study-of-baseline-clinical-features-of-334-cases
#13
Kazunori Yamada, Motohisa Yamamoto, Takako Saeki, Ichiro Mizushima, Shoko Matsui, Yuhei Fujisawa, Satoshi Hara, Hiroki Takahashi, Hideki Nomura, Shigeyuki Kawa, Mitsuhiro Kawano
BACKGROUND: The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. METHODS: Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1996 and 2015 in five hospitals by analyzing their baseline clinical features, laboratory, imaging, and pathological test findings, and treatment...
December 1, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29188293/variation-of-thyroidectomy-specific-outcomes-among-hospitals-and-their-association-with-risk-adjustment-and-hospital-performance
#14
Jason B Liu, Julie A Sosa, Raymon H Grogan, Yaoming Liu, Mark E Cohen, Clifford Y Ko, Bruce L Hall
Importance: Current surgical quality metrics might be insufficient to fully judge the quality of certain operations because they are not procedure specific. Hypocalcemia, recurrent laryngeal nerve (RLN) injury, and hematoma are considered to be the most relevant outcomes to measure after thyroidectomy. Whether these outcomes can be used as hospital quality metrics is unknown. Objectives: To evaluate whether thyroidectomy-specific outcomes vary among hospitals, whether the addition of thyroidectomy-specific variables affects risk adjustment, and whether differences in hospital performance are associated with thyroidectomy-specific care processes...
November 29, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29179578/impact-of-ssri-therapy-on-risk-of-conversion-from-mild-cognitive-impairment-to-alzheimer-s-dementia-in-individuals-with-previous-depression
#15
Claudia Bartels, Michael Wagner, Steffen Wolfsgruber, Hannelore Ehrenreich, Anja Schneider
OBJECTIVE: Depression is associated with an increased risk of Alzheimer's disease. Research has shown that the selective serotonin reuptake inhibitor (SSRI) citalopram decreases amyloid-β generation and plaque load. The authors evaluated the impact of SSRI treatment on CSF biomarkers and progression from mild cognitive impairment (MCI) to Alzheimer's dementia. METHOD: Data sets from 755 currently nondepressed participants from the longitudinal Alzheimer's Disease Neuroimaging Initiative were evaluated by Kaplan-Meier analysis and analyses of variance and covariance with ApoE4 status and age as covariates...
November 28, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29176509/doppler-indexes-of-left-ventricular-systolic-and-diastolic-function-in-relation-to-haemodynamic-load-components-in-a-general-population
#16
Nicholas Cauwenberghs, Judita Knez, José Boggia, Jan D'hooge, Wen-Yi Yang, Fang-Fei Wei, Lutgarde Thijs, Jan A Staessen, Tatiana Kuznetsova
BACKGROUND: The contribution of central pulsatility to left ventricular (LV) dysfunction might be mediated by the haemodynamic loads of forward (Pf) and backward (Pb) pulse waves. We investigated the relation between echocardiographic indexes of LV function and pulsatile loads derived by wave separation analysis (WSA). METHODS: In 755 participants, we assessed LV dimensions, transmitral blood flow and mitral annular tissue velocities. We derived central pulse pressure (cPP) from radial tonometric recordings and calculated Pf, Pb and their ratio (reflection magnitude) using an automated, pressure-based WSA algorithm...
November 25, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29175115/comparison-of-four-pd-l1-immunohistochemical-assays-in-lung-cancer
#17
Shona Hendry, David J Byrne, Gavin M Wright, Richard J Young, Sue Sturrock, Wendy A Cooper, Stephen B Fox
INTRODUCTION: Four different PD-L1 immunohistochemical assays are approved or in development as companion or complementary diagnostics to different immunotherapeutic agents in lung carcinoma. We sought to determine whether these assays are technically equivalent and whether one antibody can be used on an alternate staining platform. METHODS: Serial sections of tissue microarrays constructed from 368 cases of resected lung cancer were stained for 22C3 and 28-8 on the Dako Link 48 platform, and for SP142 and SP263 on the Ventana Benchmark Ultra platform, strictly as per product insert...
November 23, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29174520/liver-dysfunction-during-pregnancy-and-its-association-of-with-preterm-birth-in-china-a-prospective-cohort-study
#18
Xun Zhuang, Ai-Min Cui, Qin Wang, Xiao-Yan Cheng, Yi Shen, Wei-Hua Cai, Hai-Bo Li, Sheng Zhang, Gang Qin
BACKGROUND: Liver dysfunction is common in pregnancy but its association with adverse pregnancy outcomes such as preterm birth (PTB) remains unclear. METHODS: A prospective cohort of HBV-infected or uninfected pregnant women attending antenatal care was recruited at Nantong Maternal and Child Health Hospital between January 1, 2012, and June 30, 2016. Liver function tests (LFTs) were monitored through pregnancy. The primary outcomes were PTB and very PTB (delivery prior 37 and 32weeks' gestation respectively)...
November 21, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29170144/coexistence-of-tachyarrhythmias-in-patients-with-tetralogy-of-fallot
#19
Elisabeth M J P Mouws, Jolien W Roos-Hesselink, Ad J J C Bogers, Natasja M S de Groot
BACKGROUND: The expanding population of adult patients with Tetralogy of Fallot(ToF) requires knowledge of their long-term sequelae. OBJECTIVE: To examine coexistence and order of appearance of AF, other SVT, VT and VF and their impact on survival during long-term follow-up METHODS: Adult, corrected ToF patients(N=225,128male,41±12(19-79)years)were included. Medical correspondence, electrocardiograms(ECG) and Holter registrations were reviewed for documented AF, other SVT, VT and VF...
November 20, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29167892/association-of-prognostic-value-of-primary-tumor-location-in-stage-iii-colon-cancer-with-ras-and-braf-mutational-status
#20
Julien Taieb, Hampig Raphael Kourie, Jean-François Emile, Karine Le Malicot, Ralyath Balogoun, Josep Tabernero, Enrico Mini, Gunnar Folprecht, Jean-Luc Van Laethem, Claire Mulot, Olivier Bouché, Thomas Aparicio, Pierre Michel, Josef Thaler, John Bridgewater, Eric Van Cutsem, Géraldine Perkins, Come Lepage, Ramon Salazar, Pierre Laurent-Puig
Importance: We know of no data on the prognostic value of primary tumor location (PTL) according to BRAF, RAS, and microsatellite instability (MSI) status in patients who have undergone resection for colon cancer (CC) and have been treated with current standard adjuvant chemotherapy. Objective: To determine the prognostic and predictive value of PTL according to BRAF, RAS, and MSI status in patients with stage III CC receiving adjuvant treatment with FOLFOX (folinic acid [leucovorin calcium], fluorouracil, and oxaliplatin) with or without cetuximab...
November 22, 2017: JAMA Oncology
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