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https://www.readbyqxmd.com/read/28319270/evaluation-of-a-transparent-perfluorodecalin-infused-patch-as-an-adjunct-to-laser-assisted-tattoo-removal-a-pivotal-trial
#1
Brian S Biesman, Cara Costner
BACKGROUND AND OBJECTIVE: Laser-assisted treatment of tattoos is well recognized to produce opaque epidermal whitening that prevents multiple sequential passes during a single treatment session. The amount of epidermal whitening produced in association with the procedure can be minimized by topical application of perfluorodecalin (PFD), which is an optical clearing agent. This pivotal trial assessed the ability of a transparent PFD-infused patch used in conjunction with a Q-switched nanosecond laser in the treatment of tattoos to permit multiple laser passes during a single 5 minute treatment session in comparison to the number of passes that could be completed using conventional treatment of the tattoo with the laser alone...
March 20, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28298809/predictive-value-of-mir-219-1-mir-938-mir-34b-c-and-mir-218-polymorphisms-for-gastric-cancer-susceptibility-and-prognosis
#2
Yanhua Wu, Zhifang Jia, Donghui Cao, Chuan Wang, Xing Wu, Lili You, Simin Wen, Yuchen Pan, Xueyuan Cao, Jing Jiang
Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility...
2017: Disease Markers
https://www.readbyqxmd.com/read/28295578/measurement-of-acetabular-version-based-on-biplanar-radiographs-with-3d-reconstructions-in-comparison-to-ct-as-reference-standard-in-cadavers
#3
Christoph A Agten, Maciej Jonczy, Oliver Ullrich, Christian W A Pfirrmann, Reto Sutter, Florian M Buck
INTRODUCTION: To quantify acetabular version using 3D reconstructions based on biplanar radiographs (BPR) with CT as reference standard. MATERIALS AND METHODS: No institutional review board approval was needed. Nine dry-bone pelvises underwent BPR in five different positions (rotation/tilt). 3D models of each pelvis were reconstructed by two radiologists on the basis of anatomical landmarks using semi-automated software. Automated software was used to assess the 3D models and to calculate acetabular versions perpendicular to the anterior pelvic plane on all levels in the craniocaudal direction in 1mm steps...
March 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28295491/national-trends-in-the-treatment-of-diabetic-nephropathy-in-the-united-states
#4
O Ajiboye, J B Segal
WHAT IS KNOWN AND OBJECTIVE: The prevalence of diabetic nephropathy continues to rise and it remains a strong predictor of morbidity and mortality in diabetic patients. Patients diagnosed with diabetic nephropathy are actively excluded from most trials involving diabetic medications and it is important to understand the prescription patterns in this subset of patients with diabetes. METHODS: Using the IMS Health's National Disease and Therapeutic Index, we analysed the medication prescription patterns for six classes of medications from 2010 to 2014 among patients, 35 years or older, with diabetic nephropathy...
March 15, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28295093/shot-noise-limited-laser-power-stabilization-for-the-aei-10%C3%A2-%C3%A2-m-prototype-interferometer-publisher-s-note
#5
Jonas Junker, Patrick Oppermann, Benno Willke
This note points out corrections to typographical errors in the published version of the article [Opt. Lett.42, 755 (2017)OPLEDP0146-959210.1364/OL.42.000755].
March 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28290833/-soluble-suppression-of-tumorogenicity-2-increases-opportunities-for-risk-stratification-after-acute-heart-failure-decompensation
#6
A A Skvortsov, V N Protasov, O Yu Narusov, D E Koshkina, S N Nasonova, V P Masenko, S N Tereschenko
PURPOSE: to evaluate the significance of soluble ST2-receptor (sST2) concentrations in patient (pts) risk stratification in with acute decompensated heart failure (ADHF) during long-term follow-up period. METHODS: In the prospective single-center study were included 159 pts with ADHF III-IV FC NYHA. Blood samples to determine NT-proBNP, sST2, hsTnT concentration were collected at the admission and at discharge from the hospital, and after 3, 6 and 12 months of follow-up...
January 2017: Kardiologiia
https://www.readbyqxmd.com/read/28290121/population-pharmacokinetic-analysis-of-ixazomib-an-oral-proteasome-inhibitor-including-data-from-the-phase-iii-tourmaline-mm1-study-to-inform-labelling
#7
Neeraj Gupta, Paul M Diderichsen, Michael J Hanley, Deborah Berg, Helgi van de Velde, R Donald Harvey, Karthik Venkatakrishnan
Ixazomib is an oral proteasome inhibitor, approved in USA, Canada, Australia and Europe in combination with lenalidomide and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one prior therapy. We report a population pharmacokinetic model-based analysis for ixazomib that was pivotal in describing the clinical pharmacokinetics of ixazomib, to inform product labelling. Plasma concentration-time data were collected from 755 patients who received oral or intravenous ixazomib in once- or twice-weekly schedules in ten trials, including the global phase III TOURMALINE-MM1 study...
March 13, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28289696/dataset-of-tensile-strength-development-of-concrete-with-manufactured-sand
#8
Shunbo Zhao, Feijia Hu, Xinxin Ding, Mingshuang Zhao, Changyong Li, Songwei Pei
This article presents 755 groups splitting tensile strength tests data of concrete with manufactured sand (MSC) in different curing age ranged from 1 day to 388 days related to the research article "Experimental study on tensile strength development of concrete with manufactured sand" (Zhao et al., 2017) [1]. These data were used to evaluate the precision of the prediction formulas of tensile strength of MSC, and can be applied as dataset for further studies.
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28287266/identifications-of-putative-pka-substrates-with-quantitative-phosphoproteomics-and-primary-sequence-based-scoring
#9
Haruna Imamura, Omar Wagih, Tomoya Niinae, Naoyuki Sugiyama, Pedro Beltrao, Yasushi Ishihama
Protein kinase A (PKA or cAMP-dependent protein kinase) is a serine/threonine kinase that plays essential roles in the regulation of proliferation, differentiation and apoptosis. To better understand the functions of PKA, it is necessary to elucidate the direct interplay between PKA and their substrates in living human cells. In order to identify kinase target substrates in a high-throughput manner, we firstly quantified the change of phosphoproteome in the cells of which PKA activity was perturbed by drug stimulations...
March 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28282108/a-precursor-ion-scan-mode-based-strategy-for-fast-screening-of-polyether-ionophores-by-copper-induced-gas-phase-radical-fragmentation-reactions
#10
Eduardo J Crevelin, Bruna Possato, João Luis Callegari Lopes, Norberto Peporine Lopes, Antônio Eduardo Miller Crotti
The potential of copper(II) to induce gas-phase fragmentation reactions in macrotetrolides, a class of polyether ionophores produced by Streptomyces species, was investigated by accurate-mass electrospray tandem mass spectrometry (ESI-MS/MS). Copper(II)/copper(I) transition directly induced production of diagnostic acylium ions with m/z 199, 185, 181, and 167 from α‒cleavages of [macrotetrolides+Cu]2+. A UPLC-ESI-MS/MS methodology based on the precursor ion scan of these acylium ions was developed and successfully used to identify isodinactin (1), trinactin (2), and tetranactin (3) in a crude extract of Streptomyces sp...
March 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28280851/detection-and-prevalence-of-variant-sciatic-nerve-anatomy-in-relation-to-the-piriformis-muscle-on-mri
#11
Vanja Varenika, Amelie M Lutz, Christopher F Beaulieu, Matthew D Bucknor
OBJECTIVE: To determine whether known variant anatomical relationships between the sciatic nerve and piriformis muscle can be identified on routine MRI studies of the hip and to establish their imaging prevalence. METHODS: Hip MRI studies acquired over a period of 4 years at two medical centers underwent retrospective interpretation. Anatomical relationship between the sciatic nerve and the piriformis muscle was categorized according to the Beaton and Anson classification system...
March 10, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28277868/crizotinib-treatment-for-advanced-non-small-cell-lung-cancer-patients-a-budget-impact-analysis-based-in-thailand
#12
Sumitra Thongprasert, Unchalee Permsuwan
OBJECTIVE: With the advent of anaplastic lymphoma kinase (ALK) inhibitor, treatment of advanced non-small cell lung cancer (NSCLC) patients with ALK positive has become more effective while drug cost are still a major concern. This study aimed to estimate the budget impact of crizotinib versus other standard therapies in Thai advanced NSCLC patients with ALK rearrangement. METHODS: The budget impact model was developed to estimate the net budget impact of world with crizotinib compared with world without crizotinib considering payer's perspective over a three-year period...
February 21, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28275168/clinical-trial-characteristics-and-barriers-to-participant-accrual-the-md-anderson-cancer-center-experience-over-30-years-a-historical-foundation-for-trial-improvement
#13
Chad Tang, Steven I Sherman, Mellanie Price, Jun Weng, Suzanne E Davis, David S Hong, James C Yao, Aman Buzdar, George Wilding, J Jack Lee
Purpose: Slow-accruing clinical trials delay the translation of basic biomedical research, contribute to increasing health care costs, and may prohibit trials from reaching their original goals.Experimental Design: We analyzed a prospectively maintained institutional database that tracks all clinical studies at the MD Anderson Cancer Center (Houston, TX). Inclusion criteria were activated phase I-III trials, maximum projected accrual ≥10 participants, and activation prior to March 25, 2011. The primary outcome was slow accrual, defined as <2 participants per year...
March 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28267855/association-between-dietary-factors-and-mortality-from-heart-disease-stroke-and-type-2-diabetes-in-the-united-states
#14
Renata Micha, Jose L Peñalvo, Frederick Cudhea, Fumiaki Imamura, Colin D Rehm, Dariush Mozaffarian
Importance: In the United States, national associations of individual dietary factors with specific cardiometabolic diseases are not well established. Objective: To estimate associations of intake of 10 specific dietary factors with mortality due to heart disease, stroke, and type 2 diabetes (cardiometabolic mortality) among US adults. Design, Setting, and Participants: A comparative risk assessment model incorporated data and corresponding uncertainty on population demographics and dietary habits from National Health and Nutrition Examination Surveys (1999-2002: n = 8104; 2009-2012: n = 8516); estimated associations of diet and disease from meta-analyses of prospective studies and clinical trials with validity analyses to assess potential bias; and estimated disease-specific national mortality from the National Center for Health Statistics...
March 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28267707/a-new-potential-predictor-of-coronary-artery-disease-the-ratio-of-mitral-peak-filling-velocity-to-mitral-annular-velocity-in-early-diastole
#15
Li Ma, Yanhong Li, Zhisheng Wu, Yuming Mu
BACKGROUND The aim of this study was to explore the value of the ratio of mitral peak filling velocity (E) to mitral annular velocity (e') in early diastole as a predictor of coronary artery disease (CAD). MATERIAL AND METHODS The study population consisted of 83 consecutive patients (aged 38-77 years, 22 women and 61 men) who received coronary angiography. The E/e' ratio was estimated by echocardiographic examination. Statistical significance was determined by receiver operating characteristic (ROC) curve and multiple logistic regression analyses...
March 7, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28253572/-clinical-comparative-analysis-of-surgical-resection-of-the-pregnancy-by-hysterotomy-and-hysterectomy-for-cesarean-scar-pregnancy
#16
Z Y Chen, L Zhao, Asiyan Nusilati, D Zhao, M Zhou, X M Zhang
Objective: To assess the indication and safety of surgical resection of the pregnancy by hysterotomy (SRPH) and hysterectomy for cesarean scar pregnancy (CSP). Methods: A retrospective study of women with CSP was conducted at the Women's Hospital, School of Medicine, Zhejiang University, from Jan. 2003 to Mar. 2016. The women underwent SRPH (SRPH group, n=35) and hysterectomy (Hysterectomy group, n=14) were included. The gestational age (GA), size of gestational mass(GM), level of serum β-hCG, previous treatments and clinical outcomes were analyzed...
February 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28251621/burden-of-human-scabies-in-sub-saharan-african-prisons-evidence-from-the-west-region-of-cameroon
#17
Emmanuel Armand Kouotou, Jobert Richie Nansseu, Abdoulaye Sangare, Léonnelle-Lynda Moguieu Bogne, Isidore Sieleunou, Hugues Adegbidi, Joël Tameyi Tatsa, Roger Moyou Somo
BACKGROUND/OBJECTIVES: There is little data on the profile and magnitude of scabies in sub-Saharan African prisons. The present study aimed to assess the prevalence and determinants of scabies in prisons of the west region of Cameroon. METHODS: We conducted a cross-sectional study from March to August 2014, and consecutively recruited volunteer detainees of three randomly selected prisons in the West Region of Cameroon. The diagnosis was based on clinical findings after assessment by two experienced and well-trained dermatologists...
March 1, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28245686/analyzing-cost-effectiveness-of-ulnar-and-median-nerve-transfers-to-regain-forearm-flexion
#18
Arvin R Wali, Charlie C Park, Justin M Brown, Ross Mandeville
OBJECTIVE Peripheral nerve transfers to regain elbow flexion via the ulnar nerve (Oberlin nerve transfer) and median nerves are surgical options that benefit patients. Prior studies have assessed the comparative effectiveness of ulnar and median nerve transfers for upper trunk brachial plexus injury, yet no study has examined the cost-effectiveness of this surgery to improve quality-adjusted life years (QALYs). The authors present a cost-effectiveness model of the Oberlin nerve transfer and median nerve transfer to restore elbow flexion in the adult population with upper brachial plexus injury...
March 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28244911/effects-of-the-length-of-stay-on-the-cost-of-total-knee-and-total-hip-arthroplasty-from-2002-to-2013
#19
Ilda B Molloy, Brook I Martin, Wayne E Moschetti, David S Jevsevar
BACKGROUND: Utilization of total knee and hip arthroplasty has greatly increased in the past decade in the United States; these are among the most expensive procedures in patients with Medicare. Advances in surgical techniques, anesthesia, and care pathways decrease hospital length of stay. We examined how trends in hospital cost were altered by decreases in length of stay. METHODS: Procedure, demographic, and economic data were collected on 6.4 million admissions for total knee arthroplasty and 2...
March 1, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28244777/obesidad-y-riesgo-de-infarto-de-miocardio-en-una-muestra-de-varones-europeos-el-%C3%A3-ndice-cintura-cadera-sesga-el-riesgo-real-de-la-obesidad-abdominal
#20
Ángel Martín Castellanos, María Dolores Cabañas Armesilla, Francisco Javier Barca Durán, Pedro Martín Castellanos, José Javier Gómez Barrado
Introducción: la obesidad es un factor de riesgo asociado al infarto de miocardio aunque el índice cintura-cadera ha mostrado mayor poder predictivo.Objetivo: análisis antropométrico Receiver Operating Characteristic(ROC) en infartados para identificar la fuerza discriminatoria de mediciones, obesidad, ratios cintura-cadera, ratios cintura-talla e índice de conicidad.Métodos: estudio caso-control de infarto miocárdico en varones europeos. Ciento doce casos/112 controles de 30-74 años fueron reclutados...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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