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https://www.readbyqxmd.com/read/28439940/impact-of-operator-experience-and-training-strategy-on-procedural-outcomes-with-leadless-pacing-insights-from-the-micra-transcatheter-pacing-study
#1
Mikhael El Chami, Robert C Kowal, Kyoko Soejima, Philippe Ritter, Gabor Z Duray, Petr Neuzil, Lluis Mont, Alexander Kypta, Venkata Sagi, J Harrison Hudnall, Kurt Stromberg, Dwight Reynolds
BACKGROUND: Leadless pacemaker systems have been designed to avoid the need for a pocket and transvenous lead. However, delivery of this therapy requires a new catheter-based procedure. This study evaluates the role of operator experience and different training strategies on procedural outcomes. METHODS: A total of 726 patients underwent implant attempt with the Micra transcatheter pacing system (TPS) by 94 operators trained in a teaching laboratory using a simulator, cadaver, and large animal models (lab training) or locally at the hospital with simulator/demo model and proctorship (hospital training)...
April 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28438885/prognostic-nomograms-stratify-survival-of-patients-with-hepatocellular-carcinoma-without-portal-vein-tumor-thrombosis-after-curative-resection
#2
Yi-Peng Fu, Yong Yi, Jin-Long Huang, Chu-Yu Jing, Jian Sun, Xiao-Chun Ni, Zhu-Feng Lu, Ya Cao, Jian Zhou, Jia Fan, Shuang-Jian Qiu
BACKGROUND: The prognosis of patients with hepatocellular carcinoma (HCC) without portal vein tumor thrombosis (PVTT) after curative resection is at variance. We identified the risk factors of poor postoperative prognosis and consequently developed prognostic nomograms generating individual risk of death and recurrence for this subgroup of patients with HCC. METHODS: The risk factors were identified and nomograms were developed based on a retrospective study of 734 patients in the primary cohort who underwent curative resection for HCC from 2010 to 2012...
April 24, 2017: Oncologist
https://www.readbyqxmd.com/read/28437528/automated-staging-of-age-related-macular-degeneration-using-optical-coherence-tomography
#3
Freerk G Venhuizen, Bram van Ginneken, Freekje van Asten, Mark J J P van Grinsven, Sascha Fauser, Carel B Hoyng, Thomas Theelen, Clara I Sánchez
Purpose: To evaluate a machine learning algorithm that automatically grades age-related macular degeneration (AMD) severity stages from optical coherence tomography (OCT) scans. Methods: A total of 3265 OCT scans from 1016 patients with either no signs of AMD or with signs of early, intermediate, or advanced AMD were randomly selected from a large European multicenter database. A machine learning system was developed to automatically grade unseen OCT scans into different AMD severity stages without requiring retinal layer segmentation...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28434827/comprehensive-and-reliable-classification-system-for-primary-diagnosis-of-cleft-lip-and-palate
#4
Ahmed Elsherbiny, Ahmed S Mazeed
OBJECTIVE: Due to the lack of a universally accepted classification system, we are aiming to introduce a modified comprehensive, precise and relatively simple classification system for primary diagnosis of cleft lip and palate. METHODS: The proposed classification is based on the Kernahan's striped Y diagram with more details in cleft extent and with the addition of severity scores to each cleft component. Clear definitions of cleft extents and severity degrees were described based on 400 consecutive primary cases...
March 27, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28433586/a-comparison-of-hepatic-steatosis-index-controlled-attenuation-parameter-and-ultrasound-as-noninvasive-diagnostic-tools-for-steatosis-in-chronic-hepatitis-b
#5
Liang Xu, Wei Lu, Ping Li, Feng Shen, Yu-Qiang Mi, Jian-Gao Fan
AIMS: To evaluate the value of noninvasive tools for diagnosis of hepatic steatosis in patients with chronic hepatitis B (CHB). METHODS: Consecutive treatment-naïve patients with CHB with body mass index less than 30kg/m(2) who underwent liver biopsy, ultrasound and FibroScan(®) were enrolled. The diagnostic performance of controlled attenuation parameter (CAP), hepatic steatosis index (HSI) and ultrasound for hepatic steatosis compared with liver biopsy was assessed...
March 30, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28430632/association-analysis-of-apo-gene-polymorphisms-with-ischemic-stroke-risk-a-case-control-study-in-a-chinese-han-population
#6
Rongjun Xiao, Shuaiqi Sun, Jiayi Zhang, Yongri Ouyang, Ning Zhang, Min Yang, Tianbo Jin, Ying Xia
This study aimed to assess the association of APO gene polymorphisms and ischemic stroke risk in a Chinese Han population. In this case-control study, we geno-typed 14 single nucleotide polymorphisms (SNPs) in 3 APO genes in 488 cases and 503 controls using Sequenom Mass-ARRAY technology and evaluated their association with ischemic stroke using the χ2 and genetic model analysis. In the allelic model analysis, we determined three SNPs were significantly associated with ischemic stroke: rs693 with a p value of 0...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427170/association-of-pre-operative-depressive-and-anxiety-symptoms-with-five-year-survival-of-glioma-and-meningioma-patients-a-prospective-cohort-study
#7
Adomas Bunevicius, Vytenis Pranas Deltuva, Arimantas Tamasauskas
BACKGROUND: Mental symptoms are common and associated with worse health status of brain tumor patients. We evaluated the association of pre-operative depressive and anxiety symptoms with 5-year mortality of glioma and meningioma patients. METHODS: One-hundred and fifty-two patients (mean age 56.9±14.7 years, 69% women) were evaluated for functional status (Barthel index), and depressive and anxiety symptom severity (Hospital Anxiety and Depression scale or HADS)...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426885/prognostic-implications-of-left-ventricular-global-longitudinal-strain-in-heart-failure-patients-with-narrow-qrs-complex-treated-with-cardiac-resynchronization-therapy-a-subanalysis-of-the-randomized-echocrt-trial
#8
Jeroen J Bax, Victoria Delgado, Peter Sogaard, Jagmeet P Singh, William T Abraham, Jeffrey S Borer, Kenneth Dickstein, Daniel Gras, Josep Brugada, Michele Robertson, Ian Ford, Henry Krum, Johannes Holzmeister, Frank Ruschitzka, John Gorcsan
Aim: Left ventricular (LV) global longitudinal strain (GLS) reflects LV systolic function and correlates inversely with the extent of LV myocardial scar and fibrosis. The present subanalysis of the Echocardiography Guided CRT trial investigated the prognostic value of LV GLS in patients with narrow QRS complex. Methods and results: Left ventricular (LV) global longitudinal strain (GLS) was measured on the apical 2-, 4- and 3-chamber views using speckle tracking analysis...
March 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28420406/genomics-insights-into-different-cellobiose-hydrolysis-activities-in-two-trichoderma-hamatum-strains
#9
Peng Cheng, Bo Liu, Yi Su, Yao Hu, Yahui Hong, Xinxin Yi, Lei Chen, Shengying Su, Jeffrey S C Chu, Nansheng Chen, Xingyao Xiong
BACKGROUND: Efficient biomass bioconversion is a promising solution to alternative energy resources and environmental issues associated with lignocellulosic wastes. The Trichoderma species of cellulolytic fungi have strong cellulose-degrading capability, and their cellulase systems have been extensively studied. Currently, a major limitation of Trichoderma strains is their low production of β-glucosidases. RESULTS: We isolated two Trichoderma hamatum strains YYH13 and YYH16 with drastically different cellulose degrading efficiencies...
April 19, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28419878/effect-of-gross-total-resection-gtr-in-who-grade-ii-astrocytomas-a-seer-based-survival-analysis
#10
Alexander J Schupper, Brian R Hirshman, Kate T Carroll, Mir Amaan Ali, Bob S Carter, Clark C Chen
INTRODUCTION: We wished to compare the survival benefit associated with gross total resection (GTR) in World Health Organization (WHO) grade II astrocytomas (A2) to those of grade III (A3) and grade IV (glioblastoma) astrocytomas. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) Program (1999-2010) database, we identified 4,113 A2 patients. Surgical resection was defined as GTR, subtotal resection (STR), or no resection. Kaplan-Meier and multivariate Cox proportional hazards analyses were used to assess survival with respect to extent of resection (EOR)...
April 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28415064/physical-demands-of-multimodal-training-competitions-and-their-relationship-to-measures-of-performance
#11
Andrew R Jagim, Owen Rader, Margaret T Jones, Jonathan M Oliver
Jagim, AR, Rader, O, Jones, MT, and Oliver, JM. Physical demands of multimodal training competitions and their relationship to measures of performance. J Strength Cond Res 31(5): 1212-1220, 2017-The purpose of this study was to identify the physical demands of multimodal training (MMT) competitions and to determine the extent of their relationship to select measures of performance. Eighteen (>1.5 years of strength training experience) men (n = 10) and women (n = 8) (mean ± SD; age: 37.8 ± 10.6 years, height: 172...
May 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28414006/unit-cost-of-common-illness-management-a-comparison-between-a-primary-care-unit-and-a-community-pharmacy-in-thailand
#12
Kritsanee Saramunee, Chanuttha Ploylearmsang, Surasak Chaiyasong, Wiraphol Phimarn, Phayom Sookaneknun
Aim This study was to perform unit cost analysis of managing common illnesses comparing between a primary care unit (PCU) and a community pharmacy. BACKGROUND: PCU is a key point of access for primary care in Thailand. Although a community pharmacy is an ideal setting, it has not been successfully incorporated in Thailand's health service. Common illnesses are encountered everyday by community pharmacists, an appropriate compensation for this service has not been established. METHODS: A primary care service of one educational institution was a study site...
April 17, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28413644/reduction-in-mirna-125b-5p-levels-is-associated-with-obstructive-renal-injury
#13
Silu Wang, Lianfeng Wu, Linyong Du, Hong Lu, Bicheng Chen, Yongheng Bai
Obstructive renal injury is a common disease that leads to progressive glomerulosclerosis, tubulointerstitial fibrosis and loss of renal function. MicroRNAs (miRNAs/miRs) are small non-coding molecules that may be involved in the progression of many renal diseases. The aim of the present study was to investigate the roles of miRNAs, including miR-125b, miR-326 and miR-324p, in obstructive renal injury. Blood samples were collected from 91 patients with ureteral obstruction and 76 controls to examine renal function...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28413086/clinically-feasible-stratification-of-3-year-chronic-disease-risk-in-primary-care-the-mental-health-integration-risk-score
#14
Heidi T May, Brenda Reiss-Brennan, Kimberly D Brunisholz, Benjamin D Horne
BACKGROUND: Depression is a common illness that imposes a disproportionately large health burden. Depression is generally associated with a higher prevalence of chronic disease risk factors and may contribute to higher chronic disease risk. OBJECTIVE: This study aimed to create and validate sex-specific Mental Health Integration Risk Scores (MHIRS) that predict 3-year chronic disease diagnosis. METHODS: MHIRS was created to predict the first diagnosis of any of the 10 chronic diseases in patients completing a Patient Health Questionnaire-9 Depression Survey who were free at baseline from those 10 chronic disease diagnoses...
March 9, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28412067/trend-based-analysis-of-ganglion-cell-inner-plexiform-layer-thickness-changes-on-optical-coherence-tomography-in-glaucoma-progression
#15
Won June Lee, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
PURPOSE: To evaluate the rate of thinning in ganglion cell-inner plexiform layer (GCIPL) thickness by optical coherence tomography (OCT) in glaucomatous eyes and to use a trend-based approach to determine its diagnostic ability for detecting glaucoma progression. DESIGN: Prospective, observational study. PARTICIPANTS: Sixty-five patients with primary open-angle glaucoma with a minimum 3-year follow-up involving serial spectral-domain OCT measurement of GCIPL thickness...
April 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28408113/surgical-outcomes-in-women-%C3%A2-70-years-undergoing-mastectomy-with-and-without-reconstruction-for-breast-cancer
#16
Simone Mays, Hanan Alabdulkareem, Paul Christos, Rache Simmons, Tracy-Ann Moo
BACKGROUND: Approximately 4% of women age 70 will develop breast cancer during the next ten years. Reconstruction has become a standard option for young women undergoing mastectomy for breast cancer, however may not be offered to older women due to the presence of co-morbidities. There is limited data on the outcomes of mastectomy with reconstruction in patient's ≥ 70. This study examines comorbidities and 30-day complication rates in patients ≥70 undergoing mastectomy for breast cancer...
April 5, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28407975/chemical-composition-of-lycium-europaeum-fruit-oil-obtained-by-supercritical-co2-extraction-and-evaluation-of-its-antioxidant-activity-cytotoxicity-and-cell-absorption
#17
Antonella Rosa, Andrea Maxia, Danilo Putzu, Angela Atzeri, Benedetta Era, Antonella Fais, Cinzia Sanna, Alessandra Piras
We studied the total phenols and flavonoids, liposoluble antioxidants, fatty acid and triacylglycerol profiles, and oxidative status of oil obtained from Lycium europaeum fruits following supercritical CO2 extraction (at 30MPa and 40°C). Linoleic (52%), palmitic (18%), oleic (13%), and α-linolenic (6%) were the main oil fatty acids, while trilinolein and palmitodilinolein/oleodilinolein represented the main triacylglycerols. The oil was characterized by high levels of all-trans-zeaxanthin and all-trans-β-carotene (755 and 332μg/g of oil, respectively), α-tocopherol (308μg/g of oil), total phenols (13...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28407824/-association-between-high-mobility-group-box-1-and-neonatal-respiratory-distress-syndrome
#18
Wen-Xiu Wang, Bo Chen, Wei Zhang, Hui-Rong Zhang
OBJECTIVE: To study the association between serum level of high-mobility group box 1(HMGB1) and neonatal respiratory distress syndrome (NRDS). METHODS: A total of 35 infants with NRDS and 35 normal neonates (control group) were enrolled. Peripheral venous blood samples were collected with 12-24 hours after birth. ELISA was used to measure the serum level of HMGB1. RESULTS: The infants with mild and severe NRDS had a significantly higher serum level of HMGB1 than the control group (P<0...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28406866/successful-treatment-of-a-residual-thick-infantile-hemangioma-in-a-darker-phototype-pediatric-patient-using-the-755-nm-long-pulsed-alexandrite-laser
#19
Hao Feng, Arielle N B Kauvar
No abstract text is available yet for this article.
April 11, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28396964/space-time-analysis-of-gravitropism-in-etiolated-arabidopsis-hypocotyls-using-bioluminescence-imaging-of-the-iaa19-promoter-fusion-with-a-destabilized-luciferase-reporter
#20
Kotaro T Yamamoto, Masaaki K Watahiki, Jun Matsuzaki, Soichirou Satoh, Hisayo Shimizu
Imaging analysis was carried out during the gravitropic response of etiolated Arabidopsis hypocotyls, using an IAA19 promoter fusion of destabilized luciferase as a probe. From the bright-field images we obtained the local deflection angle to the vertical, A, local curvature, C, and the partial derivative of C with respect to time, [Formula: see text]. These were determined every 19.9 µm along the curvilinear length of the hypocotyl, at ~10 min intervals over a period of ~6 h after turning hypocotyls through 90° to the horizontal...
April 10, 2017: Journal of Plant Research
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