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Tsai-Wang Huang, Kuan-Hsun Lin, Hsu-Kai Huang, Yi-I Chen, Kai-Hsiung Ko, Cheng-Kuang Chang, Hsian-He Hsu, Hung Chang, Shih-Chun Lee
OBJECTIVES: The goal of this study was to investigate the role of the ground-glass opacity (GGO) ratio in lung adenocarcinoma in predicting surgical outcomes. METHODS: Patients who underwent surgical resection for pulmonary adenocarcinoma between January 2004 and December 2013 were reviewed. The clinical data, imaging characteristics of nodules, surgical approaches and outcomes were analysed with a mean follow-up of 87 months. RESULTS: Of 789 enrolled patients, 267 cases were categorized as having a GGO ratio ≥0...
February 19, 2018: European Journal of Cardio-thoracic Surgery
Jian Dai, Guoyou Yu, Jianqiang Yu
BACKGROUND: A meta-analysis was conducted to investigate the diagnostic performance of computed tomography (CT) imaging features of ground-glass opacity (GGO) to predict invasiveness. METHODS: Two reviewers independently searched PubMed, Medline, Web of Science, Cochrane Embase and CNKI for relevant studies. CT imaging signs of bubble lucency, speculation, lobulated margin, and pleural indentation were used as diagnostic references to discriminate pre-invasive and invasive disease...
February 15, 2018: Thoracic Cancer
Junichi Konma, Takuya Kotani, Takeshi Shoda, Takayasu Suzuka, Youhei Fujiki, Koji Nagai, Kenichiro Hata, Shuzo Yoshida, Tohru Takeuchi, Shigeki Makino, Shigeki Arawaka
OBJECTIVES: We retrospectively investigated efficacy and safety of combination therapy with prednisolone (PSL) and tacrolimus (TAC) for progressive interstitial pneumonitis with systemic sclerosis (SSc-PIP). METHODS: We studied 11 patients with SSc-PIP who received combination therapy with PSL (0.5 mg/kg/day) and TAC (3 mg/day). RESULTS: Baseline Hugh-Jones grades were I, II, III, and IV in 2, 6, 2, and 1 patients, respectively. KL-6 values were elevated to 914 (300-2614) U/mL...
February 14, 2018: Modern Rheumatology
Jitesh B Shewale, David B Nelson, David C Rice, Boris Sepesi, Wayne L Hofstetter, Reza J Mehran, Ara A Vaporciyan, Garrett L Walsh, Stephen G Swisher, Jack Roth, Mara B Antonoff
BACKGROUND: Among patients with previous lung cancer, the malignant potential of subsequent ground glass opacities (GGOs) on computed tomography (CT) remains unknown, with a lack of consensus regarding surveillance and intervention. We sought to describe the natural history of GGO in patients with a history of lung cancer. METHODS: A retrospective review was performed of 210 patients with a history of lung cancer and ensuing CT evidence of pure or mixed GGOs between 2007 and 2013...
February 9, 2018: Annals of Thoracic Surgery
Shigeki Suzuki, Hiroyuki Sakurai, Masaya Yotsukura, Kyohei Masai, Keisuke Asakura, Kazuo Nakagawa, Noriko Motoi, Shun-Ichi Watanabe
BACKGROUND: Ground glass opacity (GGO) dominant lung adenocarcinoma 3.0 cm or less in the whole tumor size is widely known that it has an excellent prognosis and is regarded as early lung cancer. However, the characteristics and prognosis of lung cancer showing GGO over 3.0 cm remains unclear. METHODS: From 2002 through 2012, we reviewed 3,735 lung cancers that underwent complete resection at our institution. We identified 160 (4.3%) lung cancers showing GGO over 3...
February 7, 2018: Annals of Thoracic Surgery
Fei Yao, Jian Wang, Ju Yao, Lei Xu, Junling Qian, Yongke Cao
BACKGROUND: Anatomic segmentectomy for stage I nonsmall cell lung cancer (NSCLC) has potential advantages such as preserving pulmonary function and reducing postoperative complications. However, many surgeons are deterred from this procedure for its anatomical complexity. Therefore, we presented our early experience with video-assisted thoracoscopic surgery (VATS) anatomic segmentectomy compared with our most recent VATS lobectomy cases. PATIENTS AND METHODS: Forty patients with cT1aN0M0 (ground-glass opacity [GGO] rate >50%) NSCLC underwent VATS segmentectomy from January 2015 to December 2016...
February 9, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Hanna M Nurmi, Hannu-Pekka Kettunen, Sanna-Katja Suoranta, Minna K Purokivi, Miia S Kärkkäinen, Tuomas A Selander, Riitta L Kaarteenaho
OBJECTIVE: To compare the presence and extent of several high-resolution computed tomography (HRCT) observations in different subtypes of rheumatoid arthritis-related interstitial lung disease (RA-ILD) and to examine associations between radiological findings, hospitalization, age, RA duration, pulmonary function tests (PFT) and survival. MATERIALS AND METHODS: HRCTs from 60 RA-ILD patients were independently evaluated and re-categorized into usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), organizing pneumonia (OP), diffuse alveolar damage (DAD) and unclassified subtypes by two radiologists...
January 2018: Respiratory Medicine
Guanfu Liu, Mengying Li, Guosheng Li, Zhiyong Li, Ailian Liu, Renwang Pu, Huizhi Cao, Yijun Liu
Objective: To exploit material decomposition analysis in dual-energy spectral computed tomography (CT) to assess the blood supply status of the ground-glass opacity (GGO) in lungs. Materials and Methods: This retrospective study included 48 patients with lung adenocarcinoma, who underwent a contrast-enhanced dual-energy spectral CT scan before treatment (53 GGOs in total). The iodine concentration (IC) and water content (WC) of the GGO, the contralateral and ipsilateral normal lung tissues were measured in the arterial phase (AP) and their differences were analyzed...
January 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
L Zhang, M Li, S He, R Tong, J Q Zhu, G Q Wang
Objective: To explore the diagnostic value of endobronchial ultrasonography with a guide sheath (EBUS-GS) for peripheral pulmonary ground glass opacity (GGO). Methods: The clinical data of 27 consecutive patients with 27 GGOs diagnosed by EBUS-GS between November 2014 to December 2015 in our Cancer Hospital were retrospectively analyzed. The average age of these 27 patients, including 9 males and 18 females, was 59±11 years. The median lesion size of the 27 GGOs was 2.9±1.2 cm, including 24 mixed GGOs and 3 pure GGOs...
November 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
Kieran Singhal, Andrew D Newton, Christopher Corbett, Jarrod D Predina
Partial anomalous pulmonary venous connections (PAPVCs) are rare congenital anomalies that are frequently asymptomatic in adults. When PAPVCs are encountered in the patient requiring pulmonary resection, improper management can result in fulminant right-heart failure and death. In this report, we note our management of a 70-year-old male who presented with a right upper lobe ground-glass opacity (GGO) and a PAPVC. We also provide a systematic review of all contemporary reports and provide an algorithm for PAPVC management in the adult patient requiring pulmonary resection...
December 2017: Journal of Thoracic Disease
Guang Zhao, Long Sun, Guojun Geng, Hongming Liu, Ning Li, Suhuan Liu, Bing Hao, Xiuyi Yu, Jie Jiang
Background: The aim of this study was to compare the effects of currently available preoperative localization methods, including semi-rigid single hook-wire, double-thorn hook-wire, and microcoil, in localizing the pulmonary nodules, thus to select the best technology to assist video-assisted thoracoscopic surgery (VATS) for small ground glass opacities (GGO). Methods: Preoperative CT-guided localizing techniques including semi-rigid single hook-wire, double-thorn hook-wire and microcoil were used in re-aerated fresh swine lung for location experiments...
December 2017: Journal of Thoracic Disease
Hao-Zhe Huang, Guang-Zhi Wang, Li-Chao Xu, Guo-Dong Li, Ying Wang, Yao-Hui Wang, Xin-Hong He, Wen-Tao Li
The optimal screening or treatment strategies of solitary pulmonary nodules especially ground-glass opacities (GGOs) remain controversial. With CT-guided Hookwire localization, it is accurate to find the small lesions during video-assisted thoracoscopic surgery (VATS). In this study, we evaluate the efficiency and safety of CT-guided Hookwire localization of GGO-dominant (GGO component > 50%) pulmonary nodules before VATS and investigate the correlation between the radiologic features and pathology. From April 2008 to April 2014, a total of 273 patients with solitary GGO-dominant pulmonary nodules were included...
December 8, 2017: Oncotarget
Kimikazu Takeuchi, Kazuhiko Nakayama, Mitsumasa Okano, Naoki Tamada, Hideya Suehiro, Yuto Shinkura, Kenichi Yanaka, Hiroyuki Onishi, Hidekazu Tanaka, Toshiro Shinke, Noriaki Emoto, Ken-Ichi Hirata
Clinical efficacy of combination therapy using vasodilators for pulmonary arterial hypertension (PAH) is well established. However, information on its safety are limited. We experienced a case of primary Sjogren's syndrome associated with PAH where the patient developed pulmonary edema immediately after the introduction of upfront triple combination therapy. Although the combination therapy successfully stabilized her pre-shock state, multiple ground glass opacities (GGO) emerged. We aborted the dose escalation of epoprostenol and initiated continuous furosemide infusion and noninvasive positive pressure ventilation (NPPV), but this did not prevent an exacerbation of pulmonary edema...
2018: Respiratory Medicine Case Reports
Hiroaki Komatsu, Nobuhiro Izumi, Takuma Tsukioka, Michihito Toda, Kantaro Hara, Hikaru Miyamoto, Noritoshi Nishiyama
A 66-year-old woman underwent right nephrectomy for treatment of renal cell carcinoma (RCC). Two years later, she underwent wedge resection of the right lung for treatment of metastatic RCC and primary adenocarcinoma of the lung. She began oral sorafenib for the remaining nodules of the left lung, which were suspected to be metastatic RCC. Two years later, the sorafenib was changed to everolimus because of slight enlargement of the left pulmonary nodules. The carcinoembryonic antigen (CEA) concentration then increased to 25...
December 15, 2017: Annals of Thoracic and Cardiovascular Surgery
Keiju Aokage, Tomohiro Miyoshi, Genichiro Ishii, Masahiro Kusumoto, Shogo Nomura, Shinya Katsumata, Keigo Sekihara, Kenta Tane, Masahiro Tsuboi
INTRODUCTION: The aim was to clarify the influence on patient prognosis of ground glass opacity (GGO) component in each new TNM stage and propose grouping reflecting the prognosis more accurately. METHODS: We examined the data on 1290 patients who underwent lung cancer resection from 2003 to 2011. The demographics and overall survival of patients with adenocarcinoma with and without GGO, squamous cell carcinoma, and the others were compared according to clinical stage from 0 to IB...
December 13, 2017: Journal of Thoracic Oncology
Motoyasu Sagawa, Hiroyuki Oizumi, Hiroyuki Suzuki, Hidetaka Uramoto, Katsuo Usuda, Akira Sakurada, Masayuki Chida, Satoshi Shiono, Jiro Abe, Tohru Hasumi, Masami Sato, Nobuyuki Sato, Jotaro Shibuya, Hiroyuki Deguchi, Yoshinori Okada
OBJECTIVES: The incidence of small-sized pulmonary adenocarcinomas with ground-glass opacity (GGO) has recently increased, with excellent postoperative prognosis. The limited resection of such cancers has been deemed to be acceptable based on retrospective studies. We conducted a prospective multi-institutional study evaluating the validity of limited resection for small-sized pulmonary adenocarcinoma with GGO. METHODS: The inclusion criteria were 25-80 years of age, no prior treatment, a maximum tumour diameter of 8-20 mm, a GGO ratio of ≥ 80%, clinical T1N0M0, lower 18F-fluorodeoxyglucose accumulation than the mediastinum, resectable by sublobar resection, pulmonary lobectomy tolerable and an intraoperative pathological diagnosis of bronchiloalveolar carcinoma...
December 9, 2017: European Journal of Cardio-thoracic Surgery
Liang Xue, Yunfeng Yuan
A ground-glass opacity (GGO) lesion was discovered in a 64-year-old female 1 year ago. One month before administration, a follow-up CT showed the lesion in the apical segment of left upper lobe had increased from 8 to 11 mm in diameter. The lesion was diagnosed to be cT1aN0M0 non-small cell lung cancer (NSCLC) and a 3-port video-assisted thoracic surgery (VATS) anatomic segmentectomy was performed. Intraoperative frozen sections revealed a microinvasive adenocarcinoma. Systematic lymph node dissection was then carried out...
September 2017: Journal of Thoracic Disease
Tatsuya Nitawaki, Yoshihiko Sakata, Kodai Kawamura, Kazuya Ichikado
BACKGROUND: Alectinib, a second-generation anaplastic lymphoma kinase (ALK) inhibitor, is a key drug for ALK rearranged lung adenocarcinoma. Interstitial lung disease (ILD) is an important adverse effect of alectinib, which generally requires termination of treatment. However, we treated two patients with drug-induced ILD who continued to receive alectinib. CASE PRESENTATION: Patient 1 was a 57-year-old male with an ALK-rearranged Stage IV lung adenocarcinoma who was administered alectinib as first-line therapy...
December 6, 2017: BMC Pulmonary Medicine
Yanmei Zhu, Ning Qu, Lili Sun, Xiao Meng, Xiaoyan Li, Yong Zhang
Solitary pulmonary capillary hemangioma (SPCH) is a rare type of benign lung tumor, which must be distinguished from early lung cancer and precancerous lesions of the lung that manifest in a similar way upon imaging. The current study describes a case of SPCH and a review of the literature is performed. The patient was a 40-year-old Chinese woman who was referred to the Liaoning Cancer Hospital and Institute (Shenyang, China) in October, 2015 with a cough without obvious inducement. Computed tomography (CT) demonstrated pure ground glass opacity (GGO) in the right upper lung...
December 2017: Biomedical Reports
Julip Jung, Helen Hong, Jin Mo Goo
We propose a ground-glass nodule (GGN) segmentation method that can separate solid component and ground-glass opacity (GGO) using an asymmetric multi-phase deformable model in chest CT images. First, initial solid component and GGO were extracted using intensity-based segmentation with histogram modeling. Second, the initial extracted regions were refined using an asymmetric multi-phase deformable model with modified energy functional and intensity-constrained averaging function. Finally, vessel-like structures are removed based on multi-scale shape analysis...
November 20, 2017: Computers in Biology and Medicine
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