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Youngkyu Moon, Sook Whan Sung, Min Namkoong, Jae Kil Park
BACKGROUND: The prognosis of non-small cell lung cancer (NSCLC) presenting as a ground glass opacity (GGO) nodule is better than other types of lung cancer. The purpose of this study was to evaluate the necessity of mediastinal lymph node evaluation (MLE) in clinical N0 GGO-predominant NSCLC. METHODS: We conducted a retrospective chart review of 358 patients treated for clinical N0 NSCLC that was found by curative resection to be 3 cm or smaller in size. We analyzed clinicopathological findings and survival among three groups with either GGO-predominant or solid-predominant tumor: no mediastinal lymph node evaluation (NoMLE) group, mediastinal lymph node sampling (MLS) group, and mediastinal lymph node dissection (MLND) group...
September 2016: Journal of Thoracic Disease
Youngkyu Moon, Sook Whan Sung, Kyo Young Lee, Jae Kil Park
BACKGROUND: Ground glass opacity (GGO) generally associated with the lepidic component of lung adenocarcinoma. However, in some cases, GGO nodules have been associated with invasive adenocarcinomas, where a lepidic component is minimal or absent. The purpose of this study is to evaluate the clinicopathological characteristics and prognosis of non-lepidic invasive adenocarcinoma presenting as GGO nodules. METHODS: We reviewed computed tomography (CT) images from 168 patients diagnosed with non-lepidic invasive adenocarcinoma classified as stage T1N0M0 (≤3 cm) who underwent curative anatomical resection...
September 2016: Journal of Thoracic Disease
Youngkyu Moon, Kyo Young Lee, Seok Whan Moon, Jae Kil Park
BACKGROUND: Sublobar resection of lung cancer may benefit patients with lung cancer presenting as ground-glass opacity (GGO) nodules. The purpose of this study was to evaluate the effect of margin width on recurrence after sublobar resection in patients with clinical N0 non-small cell lung cancer presenting as GGO-predominant nodule. METHODS: We conducted a retrospective chart review of 91 patients treated for clinical N0 non-small cell lung cancer ≤3 cm by sublobar resection with clear resection margins...
October 7, 2016: World Journal of Surgery
Ming-Jue Si, Xiao-Feng Tao, Guang-Ye Du, Ling-Ling Cai, Hong-Xiu Han, Xi-Zi Liang, Jiang-Min Zhao
OBJECTIVE: To retrospectively compare focal interstitial fibrosis (FIF), atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), and minimally invasive adenocarcinoma (MIA) with pure ground-glass opacity (GGO) using thin-section computed tomography (CT). MATERIALS AND METHODS: Sixty pathologically confirmed cases were reviewed including 7 cases of FIF, 17 of AAH, 23of AIS, and 13 of MIA. All nodules kept pure ground glass appearances before surgical resection and their last time of thin-section CT imaging data before operation were collected...
October 2016: European Journal of Radiology
Zongwu Lin, Junjie Xi, Songtao Xu, Qun Wang
A 63-year-old male was referred to our hospital with two existing lesions in bilateral lungs. Computed tomography (CT) showed a 15-mm ground-glass opacity (GGO) in the superior segment of left lower lung (S6) and a 5-mm GGO in the center of the right upper lobe. The preoperative clinical diagnosis was stage I primary lung cancer for the left lesion while the right lesion needed follow-up. Uniportal video-assisted thoracic surgery (VATS) left superior segmentectomy in the semiprone position was performed in this case and the right upper lobe was kept untouched...
August 2016: Journal of Thoracic Disease
Youngkyu Moon, Sook Whan Sung, Seok Whan Moon, Jae Kil Park
BACKGROUND: Sublobar resection is considered controversial for non-small cell lung cancer (NSCLC) presenting as a solid-predominant nodule. The aim of this study was to identify risk factors related to recurrence in small-sized NSCLC presenting as a solid-predominant nodule. METHODS: We conducted a retrospective chart review of 118 patients who were treated for clinical N0 NSCLC sized ≤2 cm and who underwent sublobar resection with clear resection margins. We assigned them to two groups according to radiologic features: ground glass opacity (GGO)-predominant tumor and solid-predominant tumor...
August 2016: Journal of Thoracic Disease
Koujiro Ikushima, Hidetaka Arimura, Ze Jin, Hidetake Yabu-Uchi, Jumpei Kuwazuru, Yoshiyuki Shioyama, Tomonari Sasaki, Hiroshi Honda, Masayuki Sasaki
We have proposed a computer-assisted framework for machine-learning-based delineation of gross tumor volumes (GTVs) following an optimum contour selection (OCS) method. The key idea of the proposed framework was to feed image features around GTV contours (determined based on the knowledge of radiation oncologists) into a machine-learning classifier during the training step, after which the classifier produces the 'degree of GTV' for each voxel in the testing step. Initial GTV regions were extracted using a support vector machine (SVM) that learned the image features inside and outside each tumor region (determined by radiation oncologists)...
September 8, 2016: Journal of Radiation Research
Satoshi Sato, Yoji Uejima, Meika Nanbu, Eisuke Suganuma, Tadamasa Takano, Risa Tanaka, Tomoyuki Kabuki, Eiji Oguma, Tsutomu Oh-Ishi, Yutaka Kawano
OBJECTIVES: The aim of this study was to determine the clinical phenotype and outcome of interstitial lung disease (ILD) complicated with juvenile dermatomyositis (JDM) or juvenile polymyositis (JPM). METHODS: This was a single-center retrospective study. From 1984 to 2015, we retrospectively reviewed 29 patients who were diagnosed with JDM/JPM, among whom eight cases were ILD and 21 were non-ILD. The clinical features and laboratory findings included chest computed tomography (CT) images that were compared between the patients with ILD and non-ILD...
September 20, 2016: Modern Rheumatology
Xiang-Dong Mu, Peng Jia, Li Gao, Li Su, Cheng Zhang, Ren-Gui Wang, Guang-Fa Wang
BACKGROUND: Although radiological features of pneumocystis pneumonia (PCP) in non-Acquired Immune Deficiency Syndrome (AIDS) immunocompromised patients have been reported by other authors, there were no studies on the radiological stages of PCP previously. This study aimed to elucidate the radiological stages and prognoses of PCP in non-AIDS immunocompromised patients. METHODS: Retrospective analysis of radiological manifestations and prognoses of 105 non-AIDS PCP immunocompromised patients from August 2009 to April 2016 was conducted...
2016: Chinese Medical Journal
Geewon Lee, Ki Uk Kim, Ji Won Lee, Young Ju Suh, Yeon Joo Jeong
BACKGROUND: Although fibrotic idiopathic interstitial pneumonias (IIPs) alone and those combined with pulmonary emphysema are naturally progressive diseases, the process of deterioration and outcomes are variable. PURPOSE: To evaluate and compare serial changes of computed tomography (CT) abnormalities and prognostic predictive factors in fibrotic IIPs alone and those combined with pulmonary emphysema. MATERIAL AND METHODS: A total of 148 patients with fibrotic IIPs alone (82 patients) and those combined with pulmonary emphysema (66 patients) were enrolled...
August 26, 2016: Acta Radiologica
Sang Hyun Choi, Eun Jin Chae, So Youn Shin, Eun Young Kim, Ji-Eun Kim, Hyun Joo Lee, Sang Young Oh, Sang Min Lee
To evaluate the clinical usefulness of surgical resection of persistent malignant-looking ground-glass-opacity nodules (GGN) without a preoperative tissue diagnosis.From September 1998 to November 2011, we retrospectively enrolled 288 patients (126 men, 162 women; mean age, 59.3 years) with lung adenocarcinoma proven by surgery and which appeared as GGN on chest computed tomography (CT, ground-glass-opacity [GGO] proportion >20%). We divided the study subjects into 2 groups: patients with a preoperative tissue diagnosis (PTD group, n = 207) and patients without a preoperative tissue diagnosis (No-PTD group, n = 81)...
August 2016: Medicine (Baltimore)
Fenghao Sun, Cheng Zhan, Mengkun Shi, Xiaodong Yang, Lin Wang, Wei Jiang, Zongwu Lin, Junjie Xi, Yu Shi, Qun Wang
OBJECTIVES: Mediastinal lymph node dissection is an essential component of lung cancer surgery; however, choosing mediastinal lymph nodes stations to be dissected is subjective. We carried out this research to investigate the need for dissection of station 9 lymph nodes during lung cancer surgery. METHODS: Patients with primary lung cancer who underwent radical surgery between 2010 and 2014 were retrospectively reviewed. Clinical, pathologic, and prognosis data were obtained and analyzed...
August 20, 2016: International Journal of Surgery
Hyo Jung Park, Sang Min Lee, Jin Woo Song, Sang Min Lee, Sang Young Oh, Namkug Kim, Joon Beom Seo
OBJECTIVE: The aim of our study was to retrospectively determine predictive factors for a decline in forced vital capacity (FVC) on initial CT using texture-based automated quantification in patients with idiopathic pulmonary fibrosis (IPF). MATERIALS AND METHODS: For our study, 193 patients with IPF and 1-year follow-up pulmonary function tests were enrolled in our study. A texture-based automated system used in-house software to quantify six regional CT patterns: normal, ground-glass opacity (GGO), reticular opacity (RO), honeycombing, emphysema, and consolidation...
August 17, 2016: AJR. American Journal of Roentgenology
Xiaohua Wu, Dawei Dong, Daqing Ma
BACKGROUND SARS is not only an acute disease, but also leads to long-term impaired lung diffusing capacity in some survivors. However, there is a paucity of data regarding long-term CT findings in survivors after SARS. The aim of this study was to assess the changes in lung function and lung thin-section computed tomography (CT) features in patients recovering from severe acute respiratory syndrome (SARS), especially the dynamic changes in ground-glass opacity (GGO). MATERIAL AND METHODS Clinical and radiological data from 11 patients with SARS were collected...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Youngkyu Moon, Sook Whan Sung, Kyo Young Lee, Sung Bo Sim, Jae Kil Park
BACKGROUND: Pure ground-glass opacity (GGO) on computed tomography (CT) is considered a diagnostic feature of noninvasive lung adenocarcinoma. However, pure GGO can sometimes be associated with invasive adenocarcinoma (IA). The purpose of this study was to determine the predictive factors for IA when pure GGO is present. METHODS: Between 2011 and 2014, 83 patients with persistent pure GGO on chest CT underwent surgical treatment for lung cancer. We compared the clinical, surgical, and pathological characteristics of non-IA with those of IA...
July 2016: Journal of Thoracic Disease
Junyan Zha, Dong Xie, Huikang Xie, Liping Zhang, Fangyu Zhou, Pengqing Ying, Lilan Zhao, Gening Jiang, Ke Fei, Chang Chen
BACKGROUND: Radiologically characteristic ground-glass opacity (GGO) represents a special cohort of pulmonary adenocarcinomas that has been unanimously defined as biologically inert. Lymph node metastasis, however, occurs occasionally in these biologically "indolent" cancers. The incidence and underlying risk factors of nodal metastasis remain unknown. METHODS: All surgically removed GGO lesions between January 2008 and December 2014 were retrospectively reviewed from a single treatment institution...
July 2016: Journal of Thoracic Disease
Shigeki Sawada, Natsumi Yamashita, Ryujiro Sugimoto, Tsuyoshi Ueno, Motohiro Yamashita
BACKGROUND: The long-term outcomes of follow-up care for ground-glass opacity (GGO) need to be clarified. METHODS: Between 2000 and 2005, 226 patients with pure or mixed GGOs of 3 cm or smaller in size were registered. The CT findings and changes in the findings during the follow-up period and the outcomes of the 226 patients were subsequently reviewed. RESULTS: Overall, 124 patients underwent resections, 57 did not receive follow-up examinations after 68 months because of stable disease or disease reduction and 45 were continuing to receive follow-up examinations...
July 16, 2016: Chest
Woo Sik Yu, Sae Rom Hong, Jin Gu Lee, Jae Seok Lee, Hee Suk Jung, Dae Joon Kim, Kyung Young Chung, Chang Young Lee
PURPOSE: We investigated the relationship between various parameters, including volumetric parameters, and tumor invasiveness according to the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification. MATERIALS AND METHODS: We retrospectively reviewed 99 patients with completely resected stage IA lung adenocarcinoma. The correlation between several parameters [one-dimensional ground glass opacity (1D GGO) ratio, two-dimensional (2D) GGO ratio, three-dimensional (3D) GGO ratio, 1D solid size, 2D solid size, and 3D solid size] and tumor invasiveness according to IASLC/ATS/ERS classification was investigated using receiver operating characteristic (ROC) analysis...
September 2016: Yonsei Medical Journal
Patrick Bogdanowicz, Marie-José Haure, Isabelle Ceruti, Sandrine Bessou-Touya, Nathalie Castex-Rizzi
BACKGROUND: Glycation is an aging reaction of naturally occurring sugars with dermal proteins. Type I collagen and elastin are most affected by glycation during intrinsic chronological aging. AIM: To study the in vitro and ex vivo assays in human skin cells and explants and the antiaging effects of glycylglycine oleamide (GGO). MATERIALS AND METHODS: The antiglycation effect of GGO was assessed in a noncellular in vitro study on collagen and, ex vivo, by immunohistochemical staining on human skin explants (elastin network glycation)...
2016: Clinical, Cosmetic and Investigational Dermatology
Jian Hu, Feichao Bao
Lung cancer is the leading cause of cancer-related deaths worldwide, computed tomography screening has made the disease spectrum of lung cancer shift from the previously predominating central local advanced squamous cell carcinoma to early stage lung adenocarcinoma represented by solitary pulmonary nodule, ground-glass opacity (GGO) and sub-centimeter nodule. This paper reviewed the recent proceeding in the surgical management of early stage lung cancer.
June 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
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