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Ren-Li Cen, Fei Cui, Qi Wan, Ling Chen, Xiao-Yan Huang, Jia-Xuan Zhou, Shu-Ben Li, Qing-Si Zeng, Jian-Xing He
OBJECTIVES: To evaluate the safety and efficiency of computed tomography (CT)-guided medical adhesive, α-cyanoacrylate, for preoperative localisation of pulmonary ground-glass opacity (GGO) used for guiding the video-assisted thoracoscopic surgical (VATS) excision METHODS: The procedure was performed on 188 consecutive patients with solitary GGO (pure GGO = 90 cases; mixed GGO = 98 cases) prior to the thoracoscopic procedure. The complications and efficacy of this method were analysed...
April 17, 2018: European Radiology
Marcello Migliore, Mariaconcetta Fornito, Manuela Palazzolo, Alessandra Criscione, Mariapia Gangemi, Francesco Borrata, Paolo Vigneri, Marco Nardini, Joel Dunning
Pulmonary ground glass opacity (GGO) is becoming an important clinical dilemma in oncology as its diagnosis in clinical practice is increasing due to the introduction of low dose computed tomography (CT) scan and screening. The incidence of cancer in GGO has been reported as high as 63%. The purpose of this manuscript is to review best available evidence papers on management of GGO in lung cancer to address the following questions: (I) how to correlate CT findings with malignancy; (II) when and who operate? (III) how to perform intraoperative detection of intrapulmonary GGO? (IV) wedge, segmentectomy or lobectomy? Taking a cue from a clinical scenario, a review on PubMed was conducted...
March 2018: Annals of Translational Medicine
Jarrod D Predina, Andrew Newton, Christopher Corbett, Leilei Xia, Lydia Frenzel Sulyok, Michael Shin, Charuhas Deshpande, Leslie Litzky, Eduardo Barbosa, Philip S Low, John C Kucharczuk, Sunil Singhal
PURPOSE: Intraoperative localization and resection of ill-defined pulmonary ground-glass opacities (GGOs) during minimally invasive pulmonary resection is technically challenging. Current preoperative techniques to facilitate GGO localization include microcoil and hook-wire placement, but have logistic limitations, carry safety concerns, and do not help with margin assessment. In this clinical trial, we explore an alternative method involving near-infrared molecular imaging using a folate receptor-targeted agent, OTL38, to improve localization and margin confirmation of GGOs...
April 4, 2018: Journal of Thoracic Oncology
Hideko Onoda, Tokuhiro Kimura, Hiroyuki Tao, Kazunori Okabe, Tsuneo Matsumoto, Eiji Ikeda
BACKGROUND: Pleomorphic carcinoma (PC) of the lung is a rare histological type of lung carcinoma. The association between computed tomography (CT) findings and histology with outcome remains unclear. We examined the relationships between CT features and histopathologic findings, and evaluated the impact of CT features and other clinicopathologic factors on survival. METHODS: Thirty-five consecutive patients with PC of the lung who underwent surgery between October 2010 and December 2015 were enrolled in this study...
April 6, 2018: Thoracic Cancer
Chenxi Zhong, Hiroyuki Sakurai, Shenhai Wei, Wentao Fang, Hisao Asamura
Background: Segmentectomy for small-sized stage Ia non-small cell lung cancer (NSCLC) may be comparable to lobectomy regarding prognosis and local recurrence. However, the clinical results of wedge resection for such patients are still under debate. In this international multicenter study, we retrospectively studied surgical outcomes of sublobar resections for patients with small-sized stage Ia adenocarcinoma to elucidate whether wedge resection is inferior to segmentectomy for such patients...
February 2018: Journal of Thoracic Disease
Tsutomu Shinohara, Keishi Naruse, Norihiko Hamada, Takashi Yamasaki, Nobuo Hatakeyama, Fumitaka Ogushi
Radiological findings of pulmonary infarction have been well characterized mainly in established infarction. However, the early course CT appearance of patients who develop pulmonary infarction has not yet been fully elucidated. A 50-year-old female with a history of postmenopausal hormone replacement therapy (HRT) presented with dry cough and high-resolution computed tomography (HRCT) findings of fan-shaped segmental ground-glass opacity (GGO) in the right lower lobe. As the parenchymal density in the GGO gradually enlarged over a period of 4 weeks in spite of antibiotic treatment, the patient was referred to our hospital on clinical suspicion of bronchioloalveolar cell carcinoma...
January 2018: Journal of Thoracic Disease
Mengnan Zhao, Cheng Zhan, Ming Li, Xiaodong Yang, Xinyu Yang, Yong Zhang, Miao Lin, Yifeng Xia, Mingxiang Feng, Qun Wang
Background: The aberrant status of target genes and their associations with clinicopathologic characteristics are still unclear in primary lung adenocarcinoma. Methods: The common mutations and translocations of nine target genes were evaluated in 1,247 specimens of surgically-resected primary lung adenocarcinoma. Immunohistochemistry was used to analyze the expressions of programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) in 731 specimens. The frequency of the aberrations and their associations with clinicopathologic characteristics were analyzed...
January 2018: Journal of Thoracic Disease
Dohun Kim, Hong Kwan Kim, Seok-Hyung Kim, Ho Yun Lee, Jong Ho Cho, Yong Soo Choi, Kwhanmien Kim, Jhingook Kim, Jae Ill Zo, Young Mog Shim
Background: We investigated the prognostic value of the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification and assessed the relationship between pathologic invasiveness and tumor disappearance rate (TDR) in lung adenocarcinoma with ground-glass opacity (GGO). Methods: We reviewed data from 202 consecutive patients operated on between 2000 and 2009 for clinical T1-2N0 lung adenocarcinoma with GGO and reclassified their histologic subtypes according to the IASLC/ATS/ERS classification...
January 2018: Journal of Thoracic Disease
Hanran Wu, Changqing Liu, Meiqing Xu, Ran Xiong, Guangwen Xu, Caiwei Li, Mingran Xie
BACKGROUND: Recently, the detectable rate of ground-glass opacity (GGO ) was significantly increased, a appropriate diagnosis before clinic treatment tends to be important for patients with GGO lesions. The aim of this study is to validate the ability of the mean computed tomography (m-CT) value to predict tumor invasiveness, and compared with other measurements such as Max CT value, GGO size, solid size of GGO and C/T ratio (consolid/tumor ratio, C/T) to find out the best measurement to predict tumor invasiveness...
March 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Yang Song, Naixin Liang, Shanqing Li
Due to emphasis on early screening for lung cancer, the detection rate of multiple ground glass opacities (GGOs) on computed tomography (CT) image increases in recent years, and research on multifocal adenocarcinomas presented by GGOs has been thriving. It is more common in women and non-smokers and has excellent prognosis both in patients with natural history and after surgery. These clinical features suggest that it is likely to be a distinct disease entity. From the perspective of molecular genetics, lesions in the same individual are likely to have distinct clonal features...
March 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Shaohua Ma, Tiansheng Yan, Keyi Wang, Jingdi Wang, Jintao Song, Tong Wang, Wei He, Jie Bai, Liang Jin, Hailong Liang
BACKGROUND: Segmentectomy can retains more healthy lung tissue than lobectomy, but it remains controversial in oncology for early stage lung cancer. The aim of this study is to discuss the problems of video-assisted thoracic surgery (VATS) segmentectomy in early stage lung cancer, by analyzing the clinical and pathological data of 35 cases and reviewing the literature. METHODS: There were 35 patients who received segmentectomy by complete video-assisted thoracic surgery, from May 2013 to July 2017, in single operation group in the Third Hospital of Peking University...
February 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Jianqiang Yu, Shiqiang Zhu, Zufeng Ge, Beilei Shen, Yazhi Shen, Chaojun Wang, Xiong Fang, Jian Dai
Objective: This study aimed to evaluate the value of multislice spiral computed tomography (CT) in differential diagnosis of benign or malignant pulmonary ground-glass opacity (GGO). Materials and Methods: A total of 68 patients with pulmonary GGO who received surgical treatment in our hospital from January 2014 to January 2017 were retrospectively analyzed. Postoperative pathology showed that there were 22 cases of benign GGO and 47 cases of malignant GGO (adenocarcinoma)...
January 2018: Journal of Cancer Research and Therapeutics
Tsai-Wang Huang, Kuan-Hsun Lin, Hsu-Kai Huang, Yi-I Chen, Kai-Hsiung Ko, Cheng-Kuang Chang, Hsian-He Hsu, Hung Chang, Shih-Chun Lee
OBJECTIVES: The goal of this study was to investigate the role of the ground-glass opacity (GGO) ratio in lung adenocarcinoma in predicting surgical outcomes. METHODS: Patients who underwent surgical resection for pulmonary adenocarcinoma between January 2004 and December 2013 were reviewed. The clinical data, imaging characteristics of nodules, surgical approaches and outcomes were analysed with a mean follow-up of 87 months. RESULTS: Of 789 enrolled patients, 267 cases were categorized as having a GGO ratio ≥0...
February 19, 2018: European Journal of Cardio-thoracic Surgery
Jian Dai, Guoyou Yu, Jianqiang Yu
BACKGROUND: A meta-analysis was conducted to investigate the diagnostic performance of computed tomography (CT) imaging features of ground-glass opacity (GGO) to predict invasiveness. METHODS: Two reviewers independently searched PubMed, Medline, Web of Science, Cochrane Embase and CNKI for relevant studies. CT imaging signs of bubble lucency, speculation, lobulated margin, and pleural indentation were used as diagnostic references to discriminate pre-invasive and invasive disease...
February 15, 2018: Thoracic Cancer
Junichi Konma, Takuya Kotani, Takeshi Shoda, Takayasu Suzuka, Youhei Fujiki, Koji Nagai, Kenichiro Hata, Shuzo Yoshida, Tohru Takeuchi, Shigeki Makino, Shigeki Arawaka
OBJECTIVES: We retrospectively investigated efficacy and safety of combination therapy with prednisolone (PSL) and tacrolimus (TAC) for progressive interstitial pneumonitis with systemic sclerosis (SSc-PIP). METHODS: We studied 11 patients with SSc-PIP who received combination therapy with PSL (0.5 mg/kg/d) and TAC (3 mg/d). RESULTS: Baseline Hugh-Jones grades were I, II, III, and IV in 2, 6, 2, and 1 patients, respectively. Krebs von den Lungen-6 (KL-6) values were elevated to 914 (range 300-2614) U/mL...
March 2, 2018: Modern Rheumatology
Jitesh B Shewale, David B Nelson, David C Rice, Boris Sepesi, Wayne L Hofstetter, Reza J Mehran, Ara A Vaporciyan, Garrett L Walsh, Stephen G Swisher, Jack Roth, Mara B Antonoff
BACKGROUND: Among patients with previous lung cancer, the malignant potential of subsequent ground glass opacities (GGOs) on computed tomography (CT) remains unknown, with a lack of consensus regarding surveillance and intervention. We sought to describe the natural history of GGO in patients with a history of lung cancer. METHODS: A retrospective review was performed of 210 patients with a history of lung cancer and ensuing CT evidence of pure or mixed GGOs between 2007 and 2013...
February 9, 2018: Annals of Thoracic Surgery
Shigeki Suzuki, Hiroyuki Sakurai, Masaya Yotsukura, Kyohei Masai, Keisuke Asakura, Kazuo Nakagawa, Noriko Motoi, Shun-Ichi Watanabe
BACKGROUND: Ground glass opacity (GGO) dominant lung adenocarcinoma 3.0 cm or less in the whole tumor size is widely known that it has an excellent prognosis and is regarded as early lung cancer. However, the characteristics and prognosis of lung cancer showing GGO over 3.0 cm remains unclear. METHODS: From 2002 through 2012, we reviewed 3,735 lung cancers that underwent complete resection at our institution. We identified 160 (4.3%) lung cancers showing GGO over 3...
February 7, 2018: Annals of Thoracic Surgery
Fei Yao, Jian Wang, Ju Yao, Lei Xu, Junling Qian, Yongke Cao
BACKGROUND: Anatomic segmentectomy for stage I nonsmall cell lung cancer (NSCLC) has potential advantages such as preserving pulmonary function and reducing postoperative complications. However, many surgeons are deterred from this procedure for its anatomical complexity. Therefore, we presented our early experience with video-assisted thoracoscopic surgery (VATS) anatomic segmentectomy compared with our most recent VATS lobectomy cases. PATIENTS AND METHODS: Forty patients with cT1aN0M0 (ground-glass opacity [GGO] rate >50%) NSCLC underwent VATS segmentectomy from January 2015 to December 2016...
February 9, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Hanna M Nurmi, Hannu-Pekka Kettunen, Sanna-Katja Suoranta, Minna K Purokivi, Miia S Kärkkäinen, Tuomas A Selander, Riitta L Kaarteenaho
OBJECTIVE: To compare the presence and extent of several high-resolution computed tomography (HRCT) observations in different subtypes of rheumatoid arthritis-related interstitial lung disease (RA-ILD) and to examine associations between radiological findings, hospitalization, age, RA duration, pulmonary function tests (PFT) and survival. MATERIALS AND METHODS: HRCTs from 60 RA-ILD patients were independently evaluated and re-categorized into usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), organizing pneumonia (OP), diffuse alveolar damage (DAD) and unclassified subtypes by two radiologists...
January 2018: Respiratory Medicine
Guanfu Liu, Mengying Li, Guosheng Li, Zhiyong Li, Ailian Liu, Renwang Pu, Huizhi Cao, Yijun Liu
Objective: To exploit material decomposition analysis in dual-energy spectral computed tomography (CT) to assess the blood supply status of the ground-glass opacity (GGO) in lungs. Materials and Methods: This retrospective study included 48 patients with lung adenocarcinoma, who underwent a contrast-enhanced dual-energy spectral CT scan before treatment (53 GGOs in total). The iodine concentration (IC) and water content (WC) of the GGO, the contralateral and ipsilateral normal lung tissues were measured in the arterial phase (AP) and their differences were analyzed...
January 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
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