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https://www.readbyqxmd.com/read/28089791/supplement-ct-guided-microcoil-placement-for-localising-ggo-lesions-at-blind-areas-of-the-conventional-hook-wire-technique
#1
Tao Zuo, Shunbin Shi, Long Wang, Zhe Shi, Chenyang Dai, Chuanyi Li, Xiaogang Zhao, Zhengyi Ni, Ke Fei, Chang Chen
BACKGROUND: In the conventional hook-wire technique of pulmonary nodular localisations there are several "blind areas", including the mediastinum-vicinity region, interlobar fissure-neighbouring areas and scapulae-shadowed areas. The present study aims to summarise the experiences of CT-guided microcoil placement as an alternative method for localising pulmonary ground-glass opacity (GGO) lesions before thoracoscopic wedge resections. METHODS: Sixteen GGO lesions at "blind areas" in 16 patients were localised with platinum-fibered microcoils under CT assistance before undergoing video-assisted thoracoscopic surgical resections...
November 19, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28068946/ct-characteristics-of-non-small-cell-lung-cancer-with-epidermal-growth-factor-receptor-mutation-a-systematic-review-and-meta-analysis
#2
Zenghui Cheng, Fei Shan, Yuesong Yang, Yuxin Shi, Zhiyong Zhang
BACKGROUND: To systematically investigate the relationship between CT morphological features and the presence of epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC). METHODS: All studies about the CT morphological features of NSCLC with EGFR mutations published between January 1, 2000 and March 15, 2015 were searched in the PubMed and EMBASE databases. Qualified studies were selected according to inclusion criteria. The frequency of EGFR mutations and CT features of ground-glass opacity (GGO) content, tumor size, cavitation, air-bronchogram, lobulation, and spiculation were extracted...
January 10, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28066679/image-guided-techniques-for-localizing-pulmonary-nodules-in-thoracoscopic-surgery
#3
REVIEW
Mong-Wei Lin, Jin-Shing Chen
Low-dose computed tomography (LDCT) screening has increased the detection rate for small pulmonary nodules with ground-glass opacity (GGO) in the peripheral lung parenchyma. Minimally invasive thoracoscopic surgery for these lung nodules is challenging for thoracic surgeons, and image-guided preoperative localization is mandatory for their successful resection. Image-guided localization methods primarily include two imaging tools: computed tomography (CT) and bronchoscopy. These different methods may use different localized materials, including hookwires, dyes, microcoils, fiducial markers, contrast media, and radiotracers...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28050004/interstitial-lung-disease-induced-by-pazopanib-treatment
#4
Shotaro Ide, Noriho Sakamoto, Shintaro Hara, Atsuko Hara, Tomoyuki Kakugawa, Yoichi Nakamura, Yoji Futsuki, Koichi Izumikawa, Yuji Ishimatsu, Katsunori Yanagihara, Hiroshi Mukae
Although pneumothorax has been reported to be a major pulmonary adverse event in patients treated with pazopanib, a multikinase inhibitor, drug-induced interstitial lung disease (DILD) has not been reported. A 74-year-old Japanese man who received pazopanib for the treatment of femoral leiomyosarcoma and lung metastasis presented with dyspnea and fatigue. He had mild interstitial pneumonia when pazopanib treatment was initiated. Chest computed tomography revealed progressive bilateral ground-glass opacity (GGO) and traction bronchiectasis...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28046577/tu-h-campus-jep2-03-machine-learning-based-delineation-framework-of-gtv-regions-of-solid-and-ground-glass-opacity-lung-tumors-at-datasets-of-planning-ct-and-pet-ct-images
#5
K Ikushima, H Arimura, Z Jin, H Yabuuchi, J Kuwazuru, Y Shioyama, T Sasaki, H Honda, M Sasaki
PURPOSE: In radiation treatment planning, delineation of gross tumor volume (GTV) is very important, because the GTVs affect the accuracies of radiation therapy procedure. To assist radiation oncologists in the delineation of GTV regions while treatment planning for lung cancer, we have proposed a machine-learning-based delineation framework of GTV regions of solid and ground glass opacity (GGO) lung tumors following by optimum contour selection (OCS) method. METHODS: Our basic idea was to feed voxel-based image features around GTV contours determined by radiation oncologists into a machine learning classifier in the training step, after which the classifier produced the degree of GTV for each voxel in the testing step...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28024542/guar-gum-oleate-graft-poly-methacrylic-acid-hydrogel-as-a-colon-specific-controlled-drug-delivery-carrier
#6
D Sathya Seeli, M Prabaharan
A novel type of ethylene glycol dimethacrylate (EGDMA) cross-linked guar gum oleate-graft-poly(methacrylic acid) (GGO-g-PMAc) hydrogel was prepared as a pH-responsive controlled release carrier for colon-specific drug delivery. The structure of GGO-g-PMAc hydrogel was characterized by FT-IR, (1)H NMR and X-ray diffraction (XRD) analysis. The swelling degree of the GGO-g-PMAc hydrogel at pH 7.4 was found to be higher than that at pH 1.2. The drug release studies performed in pH 7.4 and 1.2 buffer solutions at 37°C revealed that the rate and amount of drug released from the GGO-g-PMAc hydrogel at pH 7...
February 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27895751/value-of-window-technique-in-diagnosis-of-the-ground-glass-opacities-in-patients-with-non-small-cell-pulmonary-cancer
#7
Gang Yao
The aim of the present study was to examine the value of window technique in qualitative diagnosis of the ground glass opacities (GGO) in patients with non-small cell pulmonary cancer. A total of 124 clinically suspected pulmonary cancer patients were analyzed retrospectively. The lesions were affirmed by puncture biopsy, and were GGO on pulmonary window while were invisible on mediastinal window. Sixty-four multi-detector spiral computed tomography with the window width and window level of 1,500 Hounsfield units (HU) and -450 HU on pulmonary window, while the window width and window level of 400 and 40 HU on mediastinal window, was used in the study...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27894283/small-lung-lesions-invisible-under-fluoroscopy-are-located-accurately-by-three-dimensional-localization-technique-on-chest-wall-surface-and-performed-bronchoscopy-procedures-to-increase-diagnostic-yields
#8
Chaosheng Deng, Xiaoming Cao, Dawen Wu, Haibo Ding, Ruixiong You, Qunlin Chen, Linying Chen, Xin Zhang, Qiaoxian Zhang, Yongquan Wu
BACKGROUND: Nowadays, small peripheral pulmonary lesions (PPLs) are frequently detected and the prognosis of lung cancer depends on the early diagnosis. Because of the high fee and requiring specialized training, many advanced techniques are not available in many developing countries and rural districts. METHODS: Three sets of opaque soft copper wires visible under the fluoroscopy (Flu) in the Flu-flexible bronchoscopy (FB) group (n = 24), which determined the three planes of the lesion, were respectively placed firmly on the surface of the chest wall with adhesive tape on the chest wall...
November 29, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27866521/-progressions-on-diagnosis-and-treatment-of-ground-glass-opacity
#9
Yue Zhao, Rui Wang, Haiquan Chen
Pulmonary ground-glass opacity (GGO) has raised increasing attention of clinical oncologists and thoracic surgeons in recent years. GGO appears as hazy increased opacity of lung, with preservation of bronchial and vascular margins. GGO is less opaque than consolidation, in which bronchovascular margins are obscured. In most cases, GGOs are indolent, while in other cases, they may grow malignant. This pattern makes it difficult to find a standard way to treat patients with GGO. Moreover, with the improvement of technology, more and more GGOs are found in patients' computed tomgraphy (CT) scan, making it a global problem...
November 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27858088/specific-branches-of-hypoglossal-nerve-to-genioglossus-muscle-as-a-potential-target-of-selective-neurostimulation-in-obstructive-sleep-apnea-anatomical-and-morphometric-study
#10
Philippe Delaey, Jérôme Duisit, Catherine Behets, Thierry Duprez, Pierre Gianello, Benoît Lengelé
PURPOSE: To determine the ideal implantation site for selective tongue neurostimulation in obstructive sleep apnea, anatomy of the distal branching of the hypoglossal nerve (HGN) was revisited. METHODS: The HGN distal course and intramuscular distribution to the tongue muscles were studied in 17 embalmed and 5 fresh heads (age 60-98, BMI 20-35). Medial branches supplying selectively the genioglossus (GG) muscle were identified. Then, the distinct bundles entering the oblique (GGo) and horizontal (GGh) parts of the GG were located...
November 17, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27825686/usefulness-of-endobronchial-ultrasonography-with-a-guide-sheath-and-virtual-bronchoscopic-navigation-for-ground-glass-opacity-lesions
#11
Yasuyuki Ikezawa, Naofumi Shinagawa, Noriaki Sukoh, Megumi Morimoto, Hajime Kikuchi, Masahiro Watanabe, Kosuke Nakano, Satoshi Oizumi, Masaharu Nishimura
BACKGROUND: Endobronchial ultrasonography with guide sheath (EBUS-GS) could be useful for diagnosing ground-glass opacity (GGO) predominant-type lesions in the peripheral lung. Furthermore, several studies have reported that transbronchial biopsy using EBUS-GS and virtual bronchoscopic navigation (VBN) was safe and effective for diagnosing small peripheral lung lesions. Our objectives were to diagnose solitary peripheral GGO predominant-type lesions by transbronchial biopsy using EBUS-GS and VBN under radiographic fluoroscopic guidance, and to evaluate the clinical factors associated with diagnostic yield...
November 5, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27776643/clinical-and-ct-characteristics-of-surgically-resected-lung-adenocarcinomas-harboring-alk-rearrangements-or-egfr-mutations
#12
Hua Wang, Matthew B Schabath, Ying Liu, Ying Han, Qi Li, Robert J Gillies, Zhaoxiang Ye
PURPOSE: To determine if clinical and CT characteristics of surgically resected lung adenocarcinomas can distinguish those harboring ALK rearrangements from EGFR mutations. MATERIALS AND METHODS: Patients who had surgical resection and histologically confirmed lung adenocarcinoma were enrolled, including 41 patients with ALK rearrangements and 66 patients with EGFR mutations. Eighteen categorical and six quantitative CT characteristics were used to evaluate the tumors...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27747016/the-effectiveness-of-mediastinal-lymph-node-evaluation-in-a-patient-with-ground-glass-opacity-tumor
#13
Youngkyu Moon, Sook Whan Sung, Min Namkoong, Jae Kil Park
BACKGROUND: The prognosis of non-small cell lung cancer (NSCLC) presenting as a ground glass opacity (GGO) nodule is better than other types of lung cancer. The purpose of this study was to evaluate the necessity of mediastinal lymph node evaluation (MLE) in clinical N0 GGO-predominant NSCLC. METHODS: We conducted a retrospective chart review of 358 patients treated for clinical N0 NSCLC that was found by curative resection to be 3 cm or smaller in size. We analyzed clinicopathological findings and survival among three groups with either GGO-predominant or solid-predominant tumor: no mediastinal lymph node evaluation (NoMLE) group, mediastinal lymph node sampling (MLS) group, and mediastinal lymph node dissection (MLND) group...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27747010/clinicopathological-characteristics-and-prognosis-of-non-lepidic-invasive-adenocarcinoma-presenting-as-ground-glass-opacity-nodule
#14
Youngkyu Moon, Sook Whan Sung, Kyo Young Lee, Jae Kil Park
BACKGROUND: Ground glass opacity (GGO) generally associated with the lepidic component of lung adenocarcinoma. However, in some cases, GGO nodules have been associated with invasive adenocarcinomas, where a lepidic component is minimal or absent. The purpose of this study is to evaluate the clinicopathological characteristics and prognosis of non-lepidic invasive adenocarcinoma presenting as GGO nodules. METHODS: We reviewed computed tomography (CT) images from 168 patients diagnosed with non-lepidic invasive adenocarcinoma classified as stage T1N0M0 (≤3 cm) who underwent curative anatomical resection...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27718002/sublobar-resection-margin-width-does-not-affect-recurrence-of-clinical-n0-non-small-cell-lung-cancer-presenting-as-ggo-predominant-nodule-of-3%C3%A2-cm-or-less
#15
Youngkyu Moon, Kyo Young Lee, Seok Whan Moon, Jae Kil Park
BACKGROUND: Sublobar resection of lung cancer may benefit patients with lung cancer presenting as ground-glass opacity (GGO) nodules. The purpose of this study was to evaluate the effect of margin width on recurrence after sublobar resection in patients with clinical N0 non-small cell lung cancer presenting as GGO-predominant nodule. METHODS: We conducted a retrospective chart review of 91 patients treated for clinical N0 non-small cell lung cancer ≤3 cm by sublobar resection with clear resection margins...
October 7, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27666606/thin-section-computed-tomography-histopathologic-comparisons-of-pulmonary-focal-interstitial-fibrosis-atypical-adenomatous-hyperplasia-adenocarcinoma-in-situ-and-minimally-invasive-adenocarcinoma-with-pure-ground-glass-opacity
#16
Ming-Jue Si, Xiao-Feng Tao, Guang-Ye Du, Ling-Ling Cai, Hong-Xiu Han, Xi-Zi Liang, Jiang-Min Zhao
OBJECTIVE: To retrospectively compare focal interstitial fibrosis (FIF), atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), and minimally invasive adenocarcinoma (MIA) with pure ground-glass opacity (GGO) using thin-section computed tomography (CT). MATERIALS AND METHODS: Sixty pathologically confirmed cases were reviewed including 7 cases of FIF, 17 of AAH, 23of AIS, and 13 of MIA. All nodules kept pure ground glass appearances before surgical resection and their last time of thin-section CT imaging data before operation were collected...
October 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27621886/uniportal-video-assisted-thoracic-surgery-left-superior-segmentectomy-with-systematic-lymphadenectomy-in-the-semiprone-position
#17
Zongwu Lin, Junjie Xi, Songtao Xu, Qun Wang
A 63-year-old male was referred to our hospital with two existing lesions in bilateral lungs. Computed tomography (CT) showed a 15-mm ground-glass opacity (GGO) in the superior segment of left lower lung (S6) and a 5-mm GGO in the center of the right upper lobe. The preoperative clinical diagnosis was stage I primary lung cancer for the left lesion while the right lesion needed follow-up. Uniportal video-assisted thoracic surgery (VATS) left superior segmentectomy in the semiprone position was performed in this case and the right upper lobe was kept untouched...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27621855/risk-factors-for-recurrence-after-sublobar-resection-in-patients-with-small-2-cm-or-less-non-small-cell-lung-cancer-presenting-as-a-solid-predominant-tumor-on-chest-computed-tomography
#18
Youngkyu Moon, Sook Whan Sung, Seok Whan Moon, Jae Kil Park
BACKGROUND: Sublobar resection is considered controversial for non-small cell lung cancer (NSCLC) presenting as a solid-predominant nodule. The aim of this study was to identify risk factors related to recurrence in small-sized NSCLC presenting as a solid-predominant nodule. METHODS: We conducted a retrospective chart review of 118 patients who were treated for clinical N0 NSCLC sized ≤2 cm and who underwent sublobar resection with clear resection margins. We assigned them to two groups according to radiologic features: ground glass opacity (GGO)-predominant tumor and solid-predominant tumor...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27609193/computer-assisted-framework-for-machine-learning-based-delineation-of-gtv-regions-on-datasets-of-planning-ct-and-pet-ct-images
#19
Koujiro Ikushima, Hidetaka Arimura, Ze Jin, Hidetake Yabu-Uchi, Jumpei Kuwazuru, Yoshiyuki Shioyama, Tomonari Sasaki, Hiroshi Honda, Masayuki Sasaki
We have proposed a computer-assisted framework for machine-learning-based delineation of gross tumor volumes (GTVs) following an optimum contour selection (OCS) method. The key idea of the proposed framework was to feed image features around GTV contours (determined based on the knowledge of radiation oncologists) into a machine-learning classifier during the training step, after which the classifier produces the 'degree of GTV' for each voxel in the testing step. Initial GTV regions were extracted using a support vector machine (SVM) that learned the image features inside and outside each tumor region (determined by radiation oncologists)...
September 8, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27588444/clinical-analysis-and-outcome-of-interstitial-lung-disease-complicated-with-juvenile-dermatomyositis-and-juvenile-polymyositis
#20
Satoshi Sato, Yoji Uejima, Meika Nanbu, Eisuke Suganuma, Tadamasa Takano, Risa Tanaka, Tomoyuki Kabuki, Eiji Oguma, Tsutomu Oh-Ishi, Yutaka Kawano
OBJECTIVES: The aim of this study was to determine the clinical phenotype and outcome of interstitial lung disease (ILD) complicated with juvenile dermatomyositis (JDM) or juvenile polymyositis (JPM). METHODS: This was a single-center retrospective study. From 1984 to 2015, we retrospectively reviewed 29 patients who were diagnosed with JDM/JPM, among whom eight cases were ILD and 21 were non-ILD. The clinical features and laboratory findings included chest computed tomography (CT) images that were compared between the patients with ILD and non-ILD...
September 20, 2016: Modern Rheumatology
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