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https://www.readbyqxmd.com/read/28988295/associations-between-clinical-data-and-computed-tomography-features-in-patients-with-epidermal-growth-factor-receptor-mutations-in-lung-adenocarcinoma
#1
Yiyuan Cao, Haibo Xu, Meiyan Liao, Yanjuan Qu, Liying Xu, Dongyong Zhu, Bicheng Wang, Sufang Tian
BACKGROUND: To analyse the differences in computed tomography (CT) features between patients with lung adenocarcinoma who have epidermal growth factor receptor (EGFR) mutations and those who have wild-type EGFR. METHODS: Patients with lung adenocarcinoma (n = 156) were enrolled from October 2013 to March 2016, including 56 patients with wild-type EGFR and 100 patients with EGFR mutations. Two independent radiologists evaluated patient characteristics and imaging features...
October 7, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28983707/clinical-and-radiological-discrimination-of-solitary-pulmonary-lesions-in-colorectal-cancer-patients
#2
Yoichi Ohtaki, Kimihiro Shimizu, Toshiteru Nagashima, Seshiru Nakazawa, Kai Obayashi, Yoko Azuma, Misaki Iijima, Takayuki Kosaka, Toshiki Yajima, Hiroomi Ogawa, Soichi Tsutsumi, Motohiro Arai, Akira Mogi, Hiroyuki Kuwano
OBJECTIVES: The lung is one of the most common organs of metastasis from colorectal cancer (CRC), and we have encountered lung cancer patients with a history of CRC. There have been few studies regarding methods used to discriminate between primary lung cancer (PLC) and pulmonary metastasis from CRC (PM-CRC) based only on preoperative findings. We retrospectively investigated predictive factors discriminating between these lesions in patients with a history of CRC. METHODS: Between 2006 and 2015, 117 patients with a history of CRC (44 patients with 47 PLC and 73 patients with 102 PM-CRC) underwent subsequent or concurrent resection of pulmonary lesions...
October 5, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28947198/prognostic-impact-of-a-ground-glass-opacity-component-in-the-clinical-t-classification-of-non-small-cell-lung-cancer
#3
Aritoshi Hattori, Takeshi Matsunaga, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki
OBJECTIVE: To determine whether solid component size and the presence of a ground glass opacity (GGO) component are independently associated with survival outcomes in patients with early-stage non-small cell lung cancer (NSCLC) using the eighth edition Lung Cancer Stage Classification. METHODS: We retrospectively evaluated 1029 surgically resected early-stage NSCLCs. T categories were assigned based on solid component size using the eighth classification. All tumors were classified into 1 of 2 groups: the GGO group or the solid group...
September 1, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28885371/clinical-and-diagnostic-features-of-angiosarcoma-with-pulmonary-metastases-a-retrospective-observational-study
#4
Hanping Wang, Juhong Shi, Hongrui Liu, Yeye Chen, Yining Wang, Wenze Wang, Li Zhang
Angiosarcoma with pulmonary metastasis is a rare, fatal disease that often presents with multiple pulmonary nodules and diffuse alveolar hemorrhage. We herein review the detailed clinical characteristics of pulmonary metastatic angiosarcoma and determine a reasonable diagnostic strategy.The medical records of 11 patients with pulmonary angiosarcoma were reviewed.The mean age of the patients was 45.7 years (range, 30-71 years). All patients were male. The most common symptom was hemoptysis (8/11). Common initial misdiagnoses were tuberculosis (5/11), vasculitis (2/11), nontuberculous infectious disease (1/11), and constrictive pericarditis (1/11)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28863952/survival-and-risk-factors-for-progression-after-resection-of-the-dominant-tumor-in-multifocal-lepidic-type-pulmonary-adenocarcinoma
#5
Rebecca W Gao, Mark F Berry, Christian A Kunder, Amanda A Khuong, Heather Wakelee, Joel W Neal, Leah M Backhus, Joseph B Shrager
BACKGROUND: It remains unclear whether a dominant lung adenocarcinoma that presents with multifocal ground glass opacities (GGOs) should be treated by local therapy. We sought to address survival in this setting and to identify risk factors for progression of unresected GGOs. METHODS: Retrospective review of 70 patients who underwent resection of a pN0, lepidic adenocarcinoma, who harbored at least 1 additional GGO. Features associated with GGO progression were determined using logistic regression and survival was evaluated using the Kaplan-Meier method...
August 1, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28828379/asymmetry-in-acute-exacerbation-of-idiopathic-pulmonary-fibrosis
#6
Akihiko Sokai, Kiminobu Tanizawa, Tomohiro Handa, Takeshi Kubo, Seishu Hashimoto, Kohei Ikezoe, Yoshinari Nakatsuka, Kensaku Aihara, Yoshio Taguchi, Shigeo Muro, Toru Oga, Sonoko Nagai, Takateru Izumi, Toyohiro Hirai, Kazuo Chin, Michiaki Mishima
Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) results in poor survival. The objective of the present study was to elucidate the impact of asymmetrical ground-glass opacity (GGO) and/or consolidation on outcomes in patients with AE-IPF. The cases of 59 consecutive patients with AE-IPF were retrospectively reviewed. High-resolution computed tomography (HRCT) at diagnosis of an AE was assessed to determine the disease extent and asymmetry. Asymmetrical AE was defined as a right-to-left ratio of GGO and consolidation ≥2...
April 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28804681/luminol-amplified-chemiluminescence-detects-mainly-superoxide-anion-produced-by-human-neutrophils
#7
Samia Bedouhène, Farida Moulti-Mati, Margarita Hurtado-Nedelec, Pham My-Chan Dang, Jamel El-Benna
Reactive oxygen species (ROS) are produced by numerous biological systems and by several phagocytes such as neutrophils and macrophages. ROS include mostly superoxide anion, hydrogen peroxide, singlet oxygen and hydroxyl radical, which are involved in a variety of biological processes such as immunity, inflammation, apoptosis and cell signaling. Thus, there is a need for a sensitive and reliable method to measure ROS. The luminol-amplified chemiluminescence technique is widely used to measure ROS production by neutrophils; however, it is unclear which ROS species are detected by this technique...
2017: American Journal of Blood Research
https://www.readbyqxmd.com/read/28770963/characteristic-analysis-of-pulmonary-ground-glass-lesions-with-the-help-of-64-slice-ct-technology
#8
Y-G Lv, J-H Bao, D-U Xu, Q-H Yan, Y-J Li, D-L Yuan, J-H Ma
OBJECTIVE: With the help of new technologies like 64-slice spiral CT, including latest AW4.4, 2D nodule comparing and analyzing technology, MPR and 3D technology, MIP technology and the technology of analyzing pulmonary vascular density by the method of perfusion scanning, we performed characteristic analysis of ground-glass opacities (GGO) for the early diagnosis of lung cancer. PATIENTS AND METHODS: We selected 62 patients suspected of lung cancer, whose conventional CT showed that they were patients with GGO...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28749172/no-differences-in-radiological-changes-after-3d-conformal-vs-vmat-based-stereotactic-radiotherapy-for-early-stage-non-small-cell-lung-cancer
#9
COMPARATIVE STUDY
Serena Badellino, Jacopo Di Muzio, Giulia Schivazappa, Alessia Guarneri, Riccardo Ragona, Sara Bartoncini, Elisabetta Trino, Andrea Riccardo Filippi, Paolo Fonio, Umberto Ricardi
OBJECTIVE: To compare patterns of acute and late radiological lung injury following either 3D conformal or image-guided volumetric modulated arc therapy stereotactic radiotherapy for Stage I non-small-cell lung cancer. METHODS: We included 148 patients from a prospective mono-institutional stereotactic body radiation therapy (SBRT) series (time interval 2004-2014), treated with prescription BED10 Gy (at 80%) in the range 100-120 Gy. The first 95 patients (2004-2010) were planned with 3D-CRT, with a stereotactic body frame...
October 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28743420/presence-of-even-a-small-ground-glass-component-in-lung-adenocarcinoma-predicts-better-survival
#10
Mark F Berry, Rebecca Gao, Christian A Kunder, Leah Backhus, Amanda Khuong, Michael Kadoch, Ann Leung, Joseph Shrager
BACKGROUND: While lepidic-predominant lung adenocarcinomas are known to have better outcomes than similarly sized solid tumors, the impact of smaller noninvasive foci within predominantly solid tumors is less clearly characterized. We tested the hypothesis that lung adenocarcinomas with even a small ground-glass opacity (GGO) component have a better prognosis than otherwise similar pure solid (PS) adenocarcinomas. PATIENTS AND METHODS: The maximum total and solid-component diameters were determined by preoperative computed tomography in patients who underwent lobar or sublobar resection of clinical N0 adenocarcinomas without induction therapy between May 2003 and August 2013...
July 8, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28738834/the-value-of-99m-tc-methylene-diphosphonate-single-photon-emission-computed-tomography-computed-tomography-in-diagnosis-of-fibrous-dysplasia
#11
Linqi Zhang, Qiao He, Wei Li, Rusen Zhang
BACKGROUND: Fibrous dysplasia (FD) is a rare benign bone disorder in which the normal bone is replaced by immature fibro-osseous tissue. However, some case reports have reported that FD showed significantly increased (99m)Tc-methylene diphosphonate ((99m)Tc-MDP) uptake on whole-body bone scintigraphy (WBS), which may mimic bone metastasis or skeletal involvement of the patients with known cancer. Thus, the purpose of present study is to observe the reliable characteristics and usefulness of single photon emission computed tomography/computed tomography (SPECT/CT) for the diagnosis of FD...
July 24, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28691431/low-dose-computed-tomography-in-assessment-of-pulmonary-abnormalities-in-children-with-febrile-neutropenia-suffering-from-malignant-diseases
#12
Urszula Zaleska-Dorobisz, Cyprian Michal Olchowy, Mateusz Łasecki, Dąbrówka Sokołowska-Dąbek, Aleksander Pawluś, Jowita Frączkiewicz, Ewa Gorczyńska
BACKGROUND: Management of febrile neutropenia in pediatric patients is challenging. Chest X-ray and CT help to identify infective foci; however, exposure to radiation is a risk factor for development of secondary cancer. For this reason, attention is paid to reduce radiation exposure. OBJECTIVES: TTo define the role of LDCT examination in early detection of pulmonary lesions in children during oncology or autoimmune treatment complicated by neutropenia related fever...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28688028/novel-assessment-of-interstitial-lung-disease-using-the-computer-aided-lung-informatics-for-pathology-evaluation-and-rating-caliper-software-system-in-idiopathic-inflammatory-myopathies
#13
Patompong Ungprasert, Katelynn M Wilton, Floranne C Ernste, Sanjay Kalra, Cynthia S Crowson, Srinivasan Rajagopalan, Brian J Bartholmai
PURPOSE: To evaluate the correlation between measurements from quantitative thoracic high-resolution CT (HRCT) analysis with "Computer-Aided Lung Informatics for Pathology Evaluation and Rating" (CALIPER) software and measurements from pulmonary function tests (PFTs) in patients with idiopathic inflammatory myopathies (IIM)-associated interstitial lung disease (ILD). METHODS: A cohort of patients with IIM-associated ILD seen at Mayo Clinic was identified from medical record review...
July 7, 2017: Lung
https://www.readbyqxmd.com/read/28649310/lung-ultrasound-has-limited-diagnostic-value-in-rare-cystic-lung-diseases-a-cross-sectional-study
#14
Jesper Rømhild Davidsen, Elisabeth Bendstrup, Daniel P Henriksen, Ole Graumann, Christian B Laursen
Background: Lung ultrasound (LUS) used to identify interstitial syndrome (IS) and pleural thickening related to diffuse parenchymal lung disease (DPLD) has shown significant correlations with ground glass opacity (GGO) on high-resolution computed tomography (HRCT). However, the applicability of LUS in patients with DPLD subtypes as rare cystic lung diseases has not previously been investigated. This study aimed to observe if distinctive LUS findings could be found in patients with lymphangioleiomyomatosis (LAM), pulmonary Langerhans cell histiocytosis (PLCH), and Birt-Hogg-Dubé syndrome (BHDS)...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28616906/-diagnosis-and-surgical-treatment-of-lung-ground-glass-opacities-a-review-of-663-cases
#15
Shi-You Wei, Ke-Jia Zhao, Cheng-Lin Guo, Jian-Dong Mei, Qiang Pu, Lin Ma, Guo-Wei Che, Long-Qi Chen, Zhu Wu, Yun Wang, Ying-Li Kou, Yi-Dan Lin, Wei-Min Li, Lun-Xu Liu
OBJECTIVES: To retrospectively investigate the clinical characteristics, surgical treatments of the patients with lung ground-glass opacities (GGO). METHODS: All the patients, who underwent surgical resection of GGO in our department from Jan. 2013 to Dec. 2016 were retrospectively reviewed. The clinicpathological features were analyzed. RESULTS: A total of 663 patients were included in this study. The rate of malignancy was 92.6% (614/663)...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28616298/imaging-guided-thoracoscopic-resection-of-a-ground-glass-opacity-lesion-in-a-hybrid-operating-room-equipped-with-a-robotic-c-arm-ct-system
#16
Chen-Ping Hsieh, Ming-Ju Hsieh, Hsin-Yueh Fang, Yin-Kai Chao
The intraoperative identification of small pulmonary nodules through video-assisted thoracoscopic surgery remains challenging. Although preoperative CT-guided nodule localization is commonly used to detect tumors during video-assisted thoracoscopic surgery (VATS), this approach carries inherent risks. We report the case of a patient with stage I lung cancer presenting as an area of ground-glass opacity (GGO) in the right upper pulmonary lobe. He successfully underwent a single-stage, CT-guided localization and removal of the pulmonary nodule within a hybrid operating room (OR) equipped with a robotic C-arm...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28577952/stereotactic-body-radiotherapy-for-operable-early-stage-non-small-cell-lung-cancer
#17
Takahisa Eriguchi, Atsuya Takeda, Naoko Sanuki, Yuichiro Tsurugai, Yousuke Aoki, Yohei Oku, Yu Hara, Takeshi Akiba, Naoyuki Shigematsu
PURPOSE: To analyze outcomes of stereotactic body radiotherapy (SBRT) for operable patients with early-stage non-small cell lung cancer (NSCLC) and to evaluate factors associated with outcomes. METHODS: We retrospectively analyzed operable patients with NSCLC, staged as cT1-2N0M0, treated with SBRT between 2006 and 2015. Both biopsy-proven and clinically diagnosed NSCLC were included. Local control and survival rates were calculated and compared between subsets of patients...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28550666/-the-correlation-study-of-ground-glass-opacity-and-lepidic-growth-pattern-component-in-stage-i-lung-invasive-adenocarcinoma
#18
L Zhang, N Wu, M Li, W Sun, L Lyu, D H Hou, D M Lin
Objective: To investigate the correlation between Ground Glass Opacity (GGO) component proportion and quantitative classification of lepidic growth pattern in pathological stage Ⅰpulmonary adenocarcinoma. Methods: Pathological and HRCT data of 183 stage Ⅰ invasive adenocarcinoma patients from January 2005 to December 2012 were retrospectively reviewed. The proportion of GGO was calculated from diameter and volume.The correlation between GGO component proportion and lepidic growth pattern in pathological were analyzed by Spearman correlation...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28523176/ct-localization-for-a-patient-with-a-ground-glass-opacity-pulmonary-nodule-expecting-thoracoscopy-a-mixture-of-lipiodol-and-india-ink
#19
Kyung Soo Kim, Kyongmin Sarah Beck, Kyo Young Lee, Seok Whan Moon
Small and deeply seated pure ground-glass opacity (GGO) pulmonary nodules (PNs) are not discernible during video-assisted thoracoscopic surgery (VATS). Moreover, pathologists have difficulty in detecting these nodules due to insufficient localization. We percutaneously injected a mixture of lipiodol and India ink during preoperative CT-guided localization in a 52-year-old female patient presenting with a pure GGO PN. A black-pigmented tattoo lesion was clearly identified, and thoracoscopic wedge resection was performed without difficulty...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28503304/clinico-pathologic-presentation-of-hypersensitivity-pneumonitis-in-egyptian-patients-a-multidisciplinary-study
#20
Dalia Abd El-Kareem, Yosri M Akl, Gina A Nakhla, Ali A Elhindawi, Mahmoud A Eltorky
BACKGROUND: Hypersensitivity pneumonitis (HP) is a common diffuse parenchymal lung disease in Egypt which can be difficult to recognize due to the dynamic symptoms & associated environmental factors. METHODS: Forty-three Egyptian patients were enrolled in this study, presenting with dyspnea and cough, predominant ground-glass opacity (GGO) in high-resolution computed tomography (HRCT) where lung biopsy was needed to establish the diagnosis. RESULTS: The age range was 15 to 60 years...
2017: Multidisciplinary Respiratory Medicine
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