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https://www.readbyqxmd.com/read/28743180/factors-predictive-of-occult-nipple-areolar-complex-involvement-in-patients-with-carcinoma-in-situ-of-the-breast
#1
Hyeoseong Hwang, Seho Park, Ja Seung Koo, Hyung Seok Park, Seung Il Kim, Young Up Cho, Byeong-Woo Park, Jung Hyun Yoon, Min Jung Kim, Eun-Kyung Kim
OBJECTIVES: To investigate predictors of occult nipple-areolar complex (NAC) involvement in patients with carcinoma in situ (CIS) and to validate an online probability calculator (CancerMath; www.lifemath.net/cancer/breastcancer/nipplecalc/index.php). METHODS: Mastectomized patients with CIS (n = 104) were retrospectively selected. Clinicopathology and preoperative mammography, ultrasound, and magnetic resonance imaging (MRI) findings were analyzed. RESULTS: Histopathological NAC-positivity was confirmed in 20 (19...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28743170/current-trends-in-patient-enrollment-for-robotic-assisted-laparoscopic-prostatectomy-in-belgium
#2
Simone Albisinni, Steven Joniau, Thierry Quackels, Greet De Coster, Peter Dekuyper, Ben Van Cleynenbreugel, Nancy Van Damme, Elisabeth Van Eycken, Filip Ameye, Thierry Roumeguère
BACKGROUND: During the last decade, an inverse stage migration has been observed in radical prostatectomy series at tertiary centers. However, it remains unclear whether similar trends can also be observed in solely robotic practices, including nonreferral centers. The aim of this study was to investigate the clinical and pathological trends in robotic-assisted laparoscopic prostatectomy (RALP) enrollment in Belgium over a period of 6 years through an analysis of a prospective registry...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28743047/bohr-effect-of-human-hemoglobin-separation-of-tertiary-and-quaternary-contributions-based-on-the-wyman-equation
#3
Kehinde Onwochei Okonjo
As a prelude to separating tertiary from quaternary structure contributions to the Bohr effect, we employed the Wyman equation to analyze Bohr data for human hemoglobin to which 2,3-bisphosphoglycerate, 2,3-BPG, is bound. Changes in the pKas of the histidine Bohr groups result in a net reduction of their contributions to the Bohr effect at pH 7.4 compared to their contributions in stripped hemoglobin. The non-histidine 2,3-BPG binding groups - the β-chain terminal amino group and Lys82β - make negative and positive contributions, respectively, to the Bohr effect...
July 15, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28743038/physiological-vascular-and-nanomechanical-assessment-of-hybrid-poplar-leaf-traits-in-micropropagated-plants-and-plants-propagated-from-root-cuttings-a-contribution-to-breeding-programs
#4
Jaroslav Ďurkovič, Hana Husárová, Lucia Javoříková, Ingrid Čaňová, Miriama Šuleková, Monika Kardošová, Ivan Lukáčik, Miroslava Mamoňová, Rastislav Lagaňa
Micropropagated plants experience significant stress from rapid water loss when they are transferred from an in vitro culture to either greenhouse or field conditions. This is caused both by inefficient stomatal control of transpiration and the change to a higher light intensity and lower humidity. Understanding the physiological, vascular and biomechanical processes that allow micropropagated plants to modify their phenotype in response to environmental conditions can help to improve both field performance and plant survival...
July 13, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28742756/cost-effectiveness-of-mindfulness-based-stress-reduction-vs-cognitive-behavioral-therapy-or-usual-care-among-adults-with-chronic-low-back-pain
#5
Patricia M Herman, Melissa L Anderson, Karen J Sherman, Benjamin H Balderson, Judith A Turner, Daniel C Cherkin
STUDY DESIGN: Economic evaluation alongside a randomized trial of cognitive-behavioral therapy (CBT) and mindfulness-based stress reduction (MBSR) versus usual care alone (UC) for chronic low-back pain (CLBP). OBJECTIVE: Determine the one-year cost-effectiveness of CBT and MBSR compared to UC. SUMMARY OF BACKGROUND DATA: CLBP is expensive in terms of healthcare costs and lost productivity. Mind-body interventions have been found effective for back pain, but their cost-effectiveness is unexplored...
July 24, 2017: Spine
https://www.readbyqxmd.com/read/28742381/systemic-error-in-radiology
#6
Stephen Waite, Jinel Moore Scott, Alan Legasto, Srinivas Kolla, Brian Gale, Elizabeth A Krupinski
OBJECTIVE: Interpretive errors in diagnostic imaging result in significant patient morbidity and mortality, but the importance of errors and process failures in the imaging cycle other than during image interpretation is underappreciated. In this article, we describe these errors and potential solutions, providing a framework to improve patient safety and understand the changing roles of radiologists beyond image interpretation. CONCLUSION: For comprehensive improvements to health care delivery, other failures in the cycle besides diagnostic interpretive error-such as ordering inappropriate studies, PACS failures, and a lack of accurate clinician contact information (with resultant communication failure)-should be recognized as contributors to patient harm because they lead to wasted resources and delayed care...
July 25, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28742358/swelling-of-random-copolymer-networks-in-pure-and-mixed-solvents-multi-component-flory-rehner-theory
#7
Rutvik V Godbole, Fardin Khabaz, Rajesh Khare, Ronald Carl Hedden
A generalized extension of Flory-Rehner (FR) theory is derived to describe equilibrium swelling of polymer networks, including copolymers with two or more chemically distinct repeat units, in either pure or mixed solvents. The model is derived by equating the chemical potential of each solvent in the liquid and gel phases at equilibrium, while assuming the deformation of the network chains is affine. Simplifications of the model are derived for specific cases involving homopolymer networks, copolymer networks, pure solvents, and binary solvent mixtures...
July 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28742015/topical-tranexamic-acid-reduces-transfusion-rates-in-simultaneous-bilateral-total-knee-arthroplasty-a-retrospective-case-series
#8
Christopher Kim, Sam S Park, Herman S Dhotar, Anthony V Perruccio, Michael G Zywiel, J Roderick Davey
BACKGROUND: Topical tranexamic acid (TA) has been reported to be effective in reducing postoperative bleeding and transfusions after TKA. The main objective of this study was to retrospectively assess the effectiveness and safety of topical TA administration in patients undergoing simultaneous bilateral TKA. METHODS: We conducted a retrospective chart review of consecutive cohorts of patients undergoing simultaneous bilateral TKA. We compared the patients who received TA with patients from a similar time frame who did not receive TA...
August 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28741940/directed-%C3%AE-c-h-amination-of-alcohols-via-radical-relay-chaperones
#9
Ethan A Wappes, Kohki M Nakafuku, David A Nagib
A radical-mediated strategy for β C-H amination of alcohols has been developed. This approach employs a radical relay chaperone, which serves as a traceless director that facilitates selective C-H functionalization via 1,5-hydrogen atom transfer (HAT) and enables net incorporation of ammonia at the β carbon of alcohols. The chaperones presented herein enable direct access to imidate radicals, allowing their first use for H atom abstraction. A streamlined protocol enables rapid conversion of alcohols to their β-amino analogs (via in situ conversion of alcohols to imidates, directed C-H amination, and hydrolysis to NH2)...
July 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28741934/mixed-spin-diamond-chain-cu2fepo4f4-h2o-4-with-a-noncollinear-spin-order-and-possible-successive-phase-transitions
#10
Hongcheng Lu, Naoaki Hayashi, Yuki Matsumoto, Hiroshi Takatsu, Hiroshi Kageyama
A diamond spin chain system, one of the one-dimensional frustrated lattices, is known to exhibit novel properties, but experimental studies have been exclusively confined to materials with a single spin component. Here, we report on the synthesis, structure, and magnetic properties of a new diamond chain compound Cu2FePO4F4(H2O)4 1 composed of mixed-spins of Cu(2+) (S = 1/2 × 2) and Fe(3+) (S = 5/2). Compound 1 crystallizes in the space group C2/c of the monoclinic crystal system with a = 7.7546(4) Å, b = 12...
July 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28741500/immunity-gone-astray-nets-in-cancer
#11
Jessica Cedervall, Anna-Karin Olsson
Neutrophil extracellular traps (NETs) have emerged as significant contributors to cancer-associated pathologies such as metastasis, thrombosis, and organ dysfunction in preclinical models. We review recent discoveries of the involvement of NETs in human cancers and suggest tumor-induced NET formation as an interesting potential therapeutic target in oncology.
November 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28741420/outreach-syncope-clinic-managed-by-a-nurse-practitioner-outcome-and-cost-effectiveness
#12
Mohamed H Hamdan, Kathleen E Walsh, Michele Brignole, Jamie Key
Introduction The purpose of this study was to assess the clinical and financial outcomes of a novel outreach syncope clinic. Methods We compared the clinical outcome of the Faint and Fall Clinic at the American Center (January-June 2016) with that of the University of Wisconsin Health and Clinics Faint and Fall Clinic (January 2013-December 2014). The American Center-Faint and Fall Clinic is run solely by a nurse practitioner, assisted by online faint-decision software and consultancy of a faint specialist through video-conferencing...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28741361/3d-printed-shape-memory-objects-based-on-olefin-ionomer-of-zinc-neutralized-poly-ethylene-co-methacrylic-acid
#13
Zhiyang Zhao, Fang Peng, Kevin A Cavicchi, Mukerrem Miko Cakmak, Robert A Weiss, Bryan D Vogt
3D printing enables the net shape manufacturing of objects with minimal material waste and low tooling costs, but the functionality is generally limited by available materials, especially for extrusion based printing such as Fused Deposition Modeling (FDM). Here we demonstrate shape memory behavior of 3D printed objects with FDM using a commercially available olefin ionomer, Surlyn 9520, which is zinc neutralized poly(ethylene-co-methacrylic acid). The initial fixity for 3D printed and compression molded samples was similar, but the initial recovery was much lower for the 3D printed sample (R=58%) than the compression molded sample (R=83%)...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28741186/effects-of-caffeine-supplementation-on-performance-in-ball-games
#14
REVIEW
Jingyi Shannon Chia, Laura Ann Barrett, Jia Yi Chow, Stephen Francis Burns
Although a large body of evidence exists documenting the ergogenic properties of caffeine, most studies have focused on endurance performance. However, findings from endurance sports cannot be generalized to performance in ball games where, apart from having a high level of endurance, successful athletic performances require a combination of physiological, technical and cognitive capabilities. The purpose of this review was to critically evaluate studies that have examined the effect of a single dose of caffeine in isolation on one or more of the following performance measures: total distance, sprint performance, agility, vertical jump performance and accuracy in ball games...
July 24, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28741105/transmission-fitness-in-co-colonization-and-the-persistence-of-bacterial-pathogens
#15
Maria Gaivão, Francisco Dionisio, Erida Gjini
Humans are often colonized by polymorphic bacteria such as Streptococcus pneumoniae, Bordetella pertussis, Staphylococcus Aureus, and Haemophilus influenzae. Two co-colonizing pathogen clones may interact with each other upon host entry and during within-host dynamics, ranging from competition to facilitation. Here we examine the significance of these exploitation strategies for bacterial spread and persistence in host populations. We model SIS epidemiological dynamics to capture the global behavior of such multi-strain systems, focusing on different parameters of single and dual colonization...
July 24, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28740863/a-nanosecond-time-resolved-xfel-analysis-of-structural-changes-associated-with-co-release-from-cytochrome-c-oxidase
#16
Atsuhiro Shimada, Minoru Kubo, Seiki Baba, Keitaro Yamashita, Kunio Hirata, Go Ueno, Takashi Nomura, Tetsunari Kimura, Kyoko Shinzawa-Itoh, Junpei Baba, Keita Hatano, Yuki Eto, Akari Miyamoto, Hironori Murakami, Takashi Kumasaka, Shigeki Owada, Kensuke Tono, Makina Yabashi, Yoshihiro Yamaguchi, Sachiko Yanagisawa, Miyuki Sakaguchi, Takashi Ogura, Ryo Komiya, Jiwang Yan, Eiki Yamashita, Masaki Yamamoto, Hideo Ago, Shinya Yoshikawa, Tomitake Tsukihara
Bovine cytochrome c oxidase (CcO), a 420-kDa membrane protein, pumps protons using electrostatic repulsion between protons transferred through a water channel and net positive charges created by oxidation of heme a (Fe a ) for reduction of O2 at heme a3 (Fe a3). For this process to function properly, timing is essential: The channel must be closed after collection of the protons to be pumped and before Fe a oxidation. If the channel were to remain open, spontaneous backflow of the collected protons would occur...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28740487/determinants-of-bacterial-morphology-from-fundamentals-to-possibilities-for-antimicrobial-targeting
#17
REVIEW
Muriel C F van Teeseling, Miguel A de Pedro, Felipe Cava
Bacterial morphology is extremely diverse. Specific shapes are the consequence of adaptive pressures optimizing bacterial fitness. Shape affects critical biological functions, including nutrient acquisition, motility, dispersion, stress resistance and interactions with other organisms. Although the characteristic shape of a bacterial species remains unchanged for vast numbers of generations, periodical variations occur throughout the cell (division) and life cycles, and these variations can be influenced by environmental conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28739647/compensatory-distal-reabsorption-drives-diuretic-resistance-in-human-heart-failure
#18
Veena S Rao, Noah Planavsky, Jennifer S Hanberg, Tariq Ahmad, Meredith A Brisco-Bacik, Francis P Wilson, Daniel Jacoby, Michael Chen, W H Wilson Tang, David Z I Cherney, David H Ellison, Jeffrey M Testani
Understanding the tubular location of diuretic resistance (DR) in heart failure (HF) is critical to developing targeted treatment strategies. Rodents chronically administered loop diuretics develop DR due to compensatory distal tubular sodium reabsorption, but whether this translates to human DR is unknown. We studied consecutive patients with HF (n=128) receiving treatment with loop diuretics at the Yale Transitional Care Center. We measured the fractional excretion of lithium (FELi), the gold standard for in vivo assessment of proximal tubular and loop of Henle sodium handling, to assess sodium exit after loop diuretic administration and FENa to assess the net sodium excreted into the urine...
July 24, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28739609/a-national-quitline-service-and-its-promotion-in-the-mass-media-modelling-the-health-gain-health-equity-and-cost-utility
#19
Nhung Nghiem, Christine L Cleghorn, William Leung, Nisha Nair, Frederieke S van der Deen, Tony Blakely, Nick Wilson
BACKGROUND: Mass media campaigns and quitlines are both important distinct components of tobacco control programmes around the world. But when used as an integrated package, the effectiveness and cost-effectiveness are not well described. We therefore aimed to estimate the health gain, health equity impacts and cost-utility of the package of a national quitline service and its promotion in the mass media. METHODS: We adapted an established Markov and multistate life-table macro-simulation model...
July 24, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28739218/phase-behavior-of-a-fc-fusion-protein-reveals-generic-patterns-of-ion-specific-perturbation-on-protein-protein-interactions
#20
Le Zhang, Lei Yu, Jian Zhang-Van Enk, Gang Huang, Jifeng Zhang
Modulation of liquid-liquid phase separation temperature (Tph) for liquid-liquid phase separation (LLPS) of a Fc-fusion protein was studied at pH values below, near and above its pI where the net charge of the protein was positive, neutral and negative, respectively, in KF, KCl, KSCN and MgCl2 solutions. At the pH value near the pI, the monotonic drop in Tph for all the salt solutions suggests that both the anion and cation can disrupt attractive protein-protein interactions, effectively salting-in the protein...
July 21, 2017: Journal of Pharmaceutical Sciences
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