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https://www.readbyqxmd.com/read/28334109/comparison-of-biofilm-ecology-supporting-growth-of-individual-naegleria-species-in-a-drinking-water-distribution-system
#1
Geoffrey J Puzon, Jason T Wylie, Tom Walsh, Kalan Braun, Matthew J Morgan
Free-living amoebae (FLA) are common components of microbial communities in drinking water distribution systems (DWDS). FLA are of clinical importance both as pathogens and as reservoirs for bacterial pathogens, so identifying the conditions promoting amoebae colonisation of DWDSs is an important public health concern for water utilities. We used high-throughput amplicon sequencing to compare eukaryotic and bacterial communities associated with DWDS biofilms supporting distinct FLA species (N. fowleri, N. lovaniensis or Vermamoeba sp...
February 21, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28290675/development-of-untargeted-metabolomics-methods-for-the-rapid-detection-of-pathogenic-naegleria-fowleri
#2
Zhihao Yu, Haylea C Miller, Geoffrey J Puzon, Brian H Clowers
Despite comparatively low levels of infection, primary amoebic meningoencephalitis (PAM) induced by Naegleria fowleri is extremely lethal with mortality rates above 95%. As a thermophile, this organism is often found in moderate to warm climates and has the potential to colonize drinking water distribution systems (DWDSs). Current detection approaches require days to obtain results whereas swift corrective action can maximize the benefit of public health. Presently, there is little information regarding the underlying in situ metabolism for this amoeba but the potential exists to exploit differentially expressed metabolic signatures as a rapid detection technique...
March 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28225265/targeting-brain-eating-amoebae-infections
#3
Naveed Ahmed Khan, Timothy Yu Yee Ong, Ruqaiyyah Siddiqui
Brain infections due to Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri often lead to death. Despite differences in the preferential sites of infection in the brain, the mode of delivery of drugs is often intravenous. Here, we discuss targeted therapeutic approach to affect parasite viability without affecting the host cells, with an eye to improve formulation of drugs and/or administration of drugs against brain-eating amoebae.
February 22, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28224696/can-contaminated-water-be-rendered-safe-for-nasal-saline-irrigations
#4
Allison G Ordemann, James K Stanford, Donna C Sullivan, J Mark Reed
OBJECTIVES/HYPOTHESIS: To compare sterile water to three methods of sterilization (carbon filtration, boiling, and ultraviolet [UV] light) for preparation of nasal saline irrigants free of bacterial and amebic contaminants. STUDY DESIGN: Bench-top translational research and cost comparison. METHODS: Sterile water was compared to common sterilization methods. Sterile water was contaminated with known concentrations of Staphylococcus aureus, Pseudomonas aeruginosa, Moraxella catarrhalis, Acinetobacter baumannii, Klebsiella pneumonia, Legionella pneumophila, and Naegleria fowleri...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28212409/pathogenic-waterborne-free-living-amoebae-an-update-from-selected-southeast-asian-countries
#5
Mohamad Azlan Abdul Majid, Tooba Mahboob, Brandon G J Mong, Narong Jaturas, Reena Leeba Richard, Tan Tian-Chye, Anusorn Phimphila, Panomphanh Mahaphonh, Kyaw Nyein Aye, Wai Lynn Aung, Joon Chuah, Alan D Ziegler, Atipat Yasiri, Nongyao Sawangjaroen, Yvonne A L Lim, Veeranoot Nissapatorn
Data on the distribution of free-living amoebae is still lacking especially in Southeast Asian region. The aquatic environment revealed a high occurrence of free-living amoebae (FLA) due to its suitable condition and availability of food source, which subsequently causes infection to humans. A total of 94 water samples consisted of both treated and untreated from Laos (31), Myanmar (42), and Singapore (21) were investigated for the presence of pathogenic FLA. Each water sample was filtered and cultured onto non-nutrient agar seeded with live suspension of Escherichia coli and incubated at room temperature...
2017: PloS One
https://www.readbyqxmd.com/read/28030337/occurrence-of-naegleria-species-in-therapeutic-geothermal-water-sources-northern-iran
#6
Ali Reza Latifi, Maryam Niyyati, Jacob Lorenzo-Morales, Ali Haghighi, Seyyed Javad Seyyed Tabaei, Zohreh Lasjerdi, Eznolah Azargashb
Potentially pathogenic Free-Living Amoebae include members belonging to Naegleria genus. The species N. fowleri is known worldwide as the causative agent of the lethal Primary Amoebic Meningoencephalitis (PAM). Only one clinical case of N. fowleri has been reported in Iran. Several species of Naegleria have been reported to be natural carriers of other potentially pathogenic microbial agents. The thermotolerance properties of this genus facilitates their presence in geothermal water sources including hot springs and spas...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28013053/surviving-naegleria-fowleri-infections-a-successful-case-report-and-novel-therapeutic-approach
#7
Travis W Heggie, Thomas Küpper
Naegleria fowleri is a deadly human pathogen recognized as the causative agent of Primary Amoebic Meningitis (PAM). N. fowleri is commonly found in warm freshwater environments such as natural or man-made lakes, hot springs, and resort spas frequented by tourists. PAM infections have a mortality rate between 95 and 99% with minimal progress being made toward a successful treatment therapy. We report the case of a 12-year old American female who survived a PAM infection and propose a new drug therapy which includes the antimicrobial drug Miltefosine...
December 22, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27980707/a-fluorescence-polarization-biophysical-assay-for-the-naegleria-dna-hydroxylase-tet1
#8
Laura J Marholz, Wei Wang, Yu Zheng, Xiang Wang
The discovery of the 5-methylcytosine (5mC) oxidation by the ten-eleven translocation (Tet) protein family was an important advancement in our understanding of DNA-modified epigenetics. Potent inhibitors of these proteins are greatly desired for both the understanding of the functions of these enzymes and to serve as eventual therapeutic leads. So far, the discovery of such small molecules with high affinity has been quite limited. Original tools to screen for activity are greatly needed in order to accelerate this process...
February 11, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27974249/elimination-of-naegleria-fowleri-from-bulk-water-and-biofilm-in-an-operational-drinking-water-distribution-system
#9
Haylea C Miller, Matthew J Morgan, Jason T Wylie, Anna H Kaksonen, David Sutton, Kalan Braun, Geoffrey J Puzon
Global incidence of primary amoebic meningoencephalitis cases associated with domestic drinking water is increasing. The need for understanding disinfectant regimes capable of eliminating the causative microorganism, Naegleria fowleri, from bulk water and pipe wall biofilms is critical. This field study demonstrated the successful elimination of N. fowleri from the bulk water and pipe wall biofilm of a persistently colonised operational drinking water distribution system (DWDS), and the prevention of further re-colonisation...
November 27, 2016: Water Research
https://www.readbyqxmd.com/read/27898739/environmental-free-living-amoebae-isolated-from-soil-in-khon-kaen-thailand-antagonize-burkholderia-pseudomallei
#10
Parumon Noinarin, Pisit Chareonsudjai, Pinich Wangsomnuk, Surasak Wongratanacheewin, Sorujsiri Chareonsudjai
Presence of Burkholderia pseudomallei in soil and water is correlated with endemicity of melioidosis in Southeast Asia and northern Australia. Several biological and physico-chemical factors have been shown to influence persistence of B. pseudomallei in the environment of endemic areas. This study was the first to evaluate the interaction of B. pseudomallei with soil amoebae isolated from B. pseudomallei-positive soil site in Khon Kaen, Thailand. Four species of amoebae, Paravahlkampfia ustiana, Acanthamoeba sp...
2016: PloS One
https://www.readbyqxmd.com/read/27867026/artemisinin-and-its-derivatives-in-treating-protozoan-infections-beyond-malaria
#11
REVIEW
Cecilia Shi Ni Loo, Nelson Siu Kei Lam, Deying Yu, Xin-Zhuan Su, Fangli Lu
Parasitic protozoan diseases continue to rank among the world's greatest global health problems, which are also common among poor populations. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. Artemisinin (ART) and its derivatives are some of the most important classes of antimalarial agents originally derived from Artemisia annua L. However, besides the outstanding antimalarial and antischistosomal activities, ART and its derivatives also possess activities against other parasitic protozoa...
November 17, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27796560/ubiquitin-like-atg8-protein-is-expressed-during-autophagy-and-the-encystation-process-in-naegleria-gruberi
#12
Roberto Cárdenas-Zúñiga, Virginia Sánchez-Monroy, Rosa María Bermúdez-Cruz, Mario Alberto Rodríguez, Jesús Serrano-Luna, Mineko Shibayama
Members of the Naegleria genus are free-living amoebae, and the only pathogenic specie described to date for humans is N. fowleri. However, as the complete genome of this specie has not been reported, non-pathogenic N. gruberi is employed to describe molecular pathways in N. fowleri. Regardless, certain mechanisms, such as autophagy, have not yet been characterized in N. gruberi. Autophagy is involved in different cellular processes in some protozoa, including the recycling of unnecessary organelles, development, and cell differentiation...
January 2017: Parasitology Research
https://www.readbyqxmd.com/read/27772819/primary-amoebic-meningoencephalitis-in-north-queensland-the-diagnostic-challenges-of-naegleria-fowleri
#13
Fiona Parsonson, Claire Nicholls
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27730363/coexistence-of-free-living-amoebae-and-bacteria-in-selected-south-african-hospital-water-distribution-systems
#14
P Muchesa, M Leifels, L Jurzik, K B Hoorzook, T G Barnard, C Bartie
Pathogenic free-living amoebae (FLA), such as Naegleria fowleri, Balamuthia mandrillaris and Acanthamoeba species isolated from aquatic environments have been implicated in central nervous system, eye and skin human infections. They also allow the survival, growth and transmission of bacteria such as Legionella, Mycobacteria and Vibrio species in water systems. The purpose of this study was to investigate the co-occurrence of potentially pathogenic FLA and their associated bacteria in hospital water networks in Johannesburg, South Africa...
January 2017: Parasitology Research
https://www.readbyqxmd.com/read/27724947/molecular-detection-of-acanthamoeba-spp-naegleria-fowleri-and-vermamoeba-hartmannella-vermiformis-as-vectors-for-legionella-spp-in-untreated-and-solar-pasteurized-harvested-rainwater
#15
Penelope H Dobrowsky, Sehaam Khan, Thomas E Cloete, Wesaal Khan
BACKGROUND: Legionella spp. employ multiple strategies to adapt to stressful environments including the proliferation in protective biofilms and the ability to form associations with free-living amoeba (FLA). The aim of the current study was to identify Legionella spp., Acanthamoeba spp., Vermamoeba (Hartmannella) vermiformis and Naegleria fowleri that persist in a harvested rainwater and solar pasteurization treatment system. METHODS: Pasteurized (45 °C, 65 °C, 68 °C, 74 °C, 84 °C and 93 °C) and unpasteurized tank water samples were screened for Legionella spp...
October 10, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27681975/primary-amoebic-meningoencephalitis-in-north-queensland-the-paediatric-experience
#16
Claire L Nicholls, Fiona Parsonson, Lawrence Ek Gray, Adele Heyer, Steven Donohue, Greg Wiseman, Robert Norton
Primary amoebic meningoencephalitis (PAM) is a fulminant, diffuse haemorrhagic meningoencephalitis caused by Naegleria fowleri, with an almost invariably fatal outcome. In Australia and the developed world, PAM remains a rare disease, although it is very likely that large numbers of cases go undetected in developing countries. N. fowleri is a thermophilic, free-living amoeba with a worldwide distribution. It is acquired when contaminated fresh water is flushed into the nose and penetrates the central nervous system via the cribriform plate...
October 3, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27643668/heterolobosean-amoebae-from-arctic-and-antarctic-extremes-18-novel-strains-of-allovahlkampfia-vahlkampfia-and-naegleria
#17
Tomáš Tyml, Kateřina Skulinová, Jan Kavan, Oleg Ditrich, Martin Kostka, Iva Dyková
The diversity of heterolobosean amoebae, important members of soil, marine and freshwater microeukaryote communities in the temperate zones, is greatly under-explored in high latitudes. To address this imbalance, we studied the diversity of this group of free-living amoebae in the Arctic and the Antarctic using culture dependent methods. Eighteen strain representatives of three heterolobosean genera, Allovahlkampfia Walochnik et Mulec, 2009 (1 strain), Vahlkampfia Chatton et Lalung-Bonnaier, 1912 (2) and Naegleria Alexeieff, 1912 (15) were isolated from 179 samples of wet soil and fresh water with sediments collected in 6 localities...
October 2016: European Journal of Protistology
https://www.readbyqxmd.com/read/27616699/biology-and-pathogenesis-of-naegleria-fowleri
#18
REVIEW
Ruqaiyyah Siddiqui, Ibne Karim M Ali, Jennifer R Cope, Naveed Ahmed Khan
Naegleria fowleri is a protist pathogen that can cause lethal brain infection. Despite decades of research, the mortality rate related with primary amoebic meningoencephalitis owing to N. fowleri remains more than 90%. The amoebae pass through the nose to enter the central nervous system killing the host within days, making it one of the deadliest opportunistic parasites. Accordingly, we present an up to date review of the biology and pathogenesis of N. fowleri and discuss needs for future research against this fatal infection...
December 2016: Acta Tropica
https://www.readbyqxmd.com/read/27614893/primary-amebic-meningoencephalitis-what-have-we-learned-in-the-last-5%C3%A2-years
#19
REVIEW
Jennifer R Cope, Ibne K Ali
Primary amebic meningoencephalitis (PAM) is a devastating infection of the brain caused by the thermophilic free-living ameba, Naegleria fowleri. Infection can occur when water containing the ameba enters the body through the nose, usually during recreational water activities such as swimming or diving. Historically, in the USA, cases were mostly reported from the warmer southern-tier states. In the last 5 years, several notable changes have been documented in PAM epidemiology including a northward expansion of infections and new types of water exposures...
September 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/27599632/asexual-amoebae-escape-muller-s-ratchet-through-polyploidy
#20
Sutherland K Maciver
While some amoebae reproduce sexually, many amoebae (e.g., Acanthamoeba, Naegleria) reproduce asexually and therefore, according to popular doctrine, are likely to have been genetically disadvantaged as a consequence. In the absence of sex, mutations are proposed to accumulate by a mechanism known as Muller's ratchet. I hypothesise that amoebae can escape the ravages of accumulated mutation by virtue of their being polyploid. The polyploid state reduces spontaneous mutation accumulation by gene conversion, the freshly mutated copy being corrected by the presence of the many other wild-type copies...
September 3, 2016: Trends in Parasitology
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