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https://www.readbyqxmd.com/read/29783270/reducing-alarm-fatigue-in-two-neonatal-intensive-care-units-through-a-quality-improvement-collaboration
#1
Kendall R Johnson, James I Hagadorn, David W Sink
OBJECTIVE:  To reduce nonactionable oximeter alarms by 80% without increasing time infants were hypoxemic (oxygen saturation [SpO2 ] ≤ 80%) or hyperoxemic (SpO2  > 95% while on supplemental oxygen). STUDY DESIGN:  In 2015, a multidisciplinary team at Connecticut Children's Medical Center initiated a quality improvement project to reduce nonactionable oximeter alarms in two referral neonatal intensive care units (NICUs). Changes made through improvement cycles included reduction of the low oximeter alarm limit for specific populations, increased low alarm delay, development of postmenstrual age-based alarm profiles, and updated bedside visual reminders...
May 21, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29783195/performance-of-a-biotrickling-filter-for-the-anaerobic-utilization-of-gas-phase-methanol-coupled-to-thiosulphate-reduction-and-resource-recovery-through-volatile-fatty-acids-production
#2
Tejaswini Eregowda, Luck Matanhike, Eldon R Rene, Piet N L Lens
The anaerobic removal of continuously fed gas-phase methanol (2.5-30 g/m3 .h) and the reduction of step-fed thiosulphate (1000 mg/L) was investigated in a biotrickling filter (BTF) operated for 123 d at an empty bed residence time (EBRT) of 4.6 and 2.3 min. The BTF performance during steady step-feed and special operational phases like intermittent liquid trickling in 6 and 24 h cycles and operation without pH regulation were evaluated. Performance of the BTF was not affected and nearly 100% removal of gas-phase methanol was achieved with an ECmax of 21 g/m3 ...
April 25, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29783155/construction-of-hierarchically-porous-monoliths-from-covalent-organic-frameworks-cofs-and-their-application-for-bisphenol-a-removal
#3
Zhongshan Liu, Hongwei Wang, Junjie Ou, Lianfang Chen, Mingliang Ye
Subject to synthetic conditions, covalent organic frameworks (COFs) are usually in powder form. Herein, taking an azine-linked COF as an example, detailed characterizations indicated that accessible aldehyde groups and hydrazine groups (CNNH2 , 88 μmol g-1 ) concurrently existed on its surface. Intrigued by such feature, we have developed an approach based on ring-opening polymerization to shape COF powder into monoliths. The crystallinity and micropore of COF in monoliths were well remained, meanwhile, the ring-opening polymerization remarkably generated macropores ranging from 0...
May 11, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29783117/changes-in-soil-nitrogen-dynamics-caused-by-prescribed-fires-in-dense-gorse-lands-in-sw-pyrenees
#4
Leire Múgica, Rosa M Canals, Leticia San Emeterio
Rural depopulation, abandonment of traditional land uses and decrease of extensive stockfarming is accelerating shrub encroachment in mountain areas. In NW Spain, gorse (Ulex gallii Planch.) is expanding, developing dense shrublands that accumulate high fuel-loads, ignite easily and persist during long periods as alternate stable states. Under this scenario, traditional bush-to-bush farming fires are being replaced by high fuel-load burnings performed by specialised teams to reduce fuels and promote mosaic landscapes...
May 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29783073/methylation-analysis-of-cmtm3-and-dusp1-gene-promoters-in-high-quality-brush-hair-in-the-yangtze-river-delta-white-goat
#5
Wang Qiang, Haiyan Guo, Yongjun Li, Jianfei Shi, Xiuyuan Yin, Jingwen Qu
The Yangtze River delta white goat is the only goat breed that produces high-quality brush hair, which is specifically used in top-grade writing brushes. Previous studies have indicated that the CMTM3 and DUSP1 genes are involved in the growth and cycle of high-quality brush hair, and these genes are thought to be involved in the formation of high-quality brush hair traits. In this study, we investigated the relationship between methylation of CMTM3 and DUSP1 and such traits. The results indicated that the relative expression levels of the CMTM3 and DUSP1 genes were higher in non-high-quality brush hair than in high-quality brush hair...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29783037/premature-progesterone-rise-on-day-of-hcg-negatively-correlated-with-live-birth-rate-in-ivf-cycles-an-analysis-of-1-022-cycles
#6
Lepage Julien, Keromnès Gwenola, Sylvie Epelboin, Luton Dominique, Yazbeck Chadi
OBJECTIVE: To investigate the relationship between serum P levels on the day of hCG administration and pregnancy outcomes in patients undergoing IVF. DESIGN: Retrospective study SETTING: Teaching hospital PATIENTS: A total of 1022 IVF-ICSI cycles, frozen embryo transfer excluded INTERVENTION(S):: Patients- all types of responder - underwent IVF with agonist or antagonist protocols. Clinical outcomes of IVF were analyzed according to plasma P levels. MAIN OUTCOME MEASURE(S): Ongoing pregnancy rates...
May 18, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29783033/coordination-of-symbiosis-and-cell-cycle-functions-in-sinorhizobium-meliloti
#7
REVIEW
Shuanghong Xue, Emanuele G Biondi
The symbiotic nitrogen fixing species Sinorhizobium meliloti represents a remarkable model system for the class Alphaproteobacteria, which includes genera such as Caulobacter, Agrobacterium and Brucella. It is capable of living free in the soil, and is also able to establish a complex symbiosis with leguminous plants, during which its cell cycle program is completely rewired presumably due, at least in part, to the action of peptides secreted by the plant. Here we will discuss how the cell cycle regulation works in S...
May 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29783020/immune-modulation-of-a-novel-lipid-soluble-extract-of-pinellia-pedatisecta-schott-in-the-tumor-microenvironment-of-an-hpv-tumor-burdened-mouse-model
#8
Haixia Huang, Mingxing Zhang, Meng Zhang, Jing Peng, Guiling Li, Congjian Xu, Suiqi Gui
ETHNOPHARMACOLOGICAL RELEVANCE: Pinellia pedatisecta Schott extract (PE), a traditional Chinese medicine, has been used to reduce swelling, dry dampness and suppress cervical tumors. AIMS: To evaluate the roles of PE in the regulation of anti-tumor effects and the cellular immune response in the tumor microenvironment. METHODS: The immune microenvironment of HPV+ TC-1 tumors was examined by immunohistochemistry, real-time PCR and flow cytometry...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29783017/the-hydro-ethanolic-extract-of-acacia-seyal-mimosaceae-stem-barks-induced-death-in-an-er-negative-breast-cancer-cell-line-by-the-intrinsic-pathway-of-apoptosis-and-inhibited-cell-migration
#9
Stephane Zingue, Thomas Michel, Julia Cisilotto, Alain Brice Tueche, Derek Tantoh Ndinteh, Leônidas João Mello, Dieudonné Njamen, Tânia Beatriz Creczynski-Pasa
BACKGROUND: Despite the significant developments occurring in the treatment of cancer, it still remains the second deadly disease, responsible for 8.2 million deaths every year. Various natural substances have been studied for active molecules of tumor suppression in the past and the tropical flora, by its diversity, continues to provide new antitumor drugs. Acacia seyal is a plant used in Cameroonian traditional system to treat cancer. It exhibited cytotoxic effects towards human breast adenocarcinoma cells...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29782931/optimal-gut-size-of-small-birds-and-its-dependence-on-environmental-and-physiological-parameters
#10
Adnane Ez-Zizi, John M McNamara, Gaurav Malhotra, Alasdair I Houston
Most optimal foraging models assume that the foraging behaviour of small birds depends on a single state variable, their energy reserves in the form of stored fat. Here, we include a second state variable-the contents of the bird's gut-to investigate how a bird should optimise its gut size to minimise its long-term mortality, depending on the availability of food, the size of meal and the bird's digestive constraints. Our results show that (1) the current level of fat is never less important than gut contents in determining the bird's survival; (2) there exists a unique optimal gut size, which is determined by a trade-off between the energetic gains and costs of maintaining a large digestive system; (3) the optimal gut size increases as the bird's digestive cycle becomes slower, allowing the bird to store undigested food; (4) the critical environmental factor for determining the optimal gut size is the mass of food found in a successful foraging effort ("meal size")...
May 18, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29782928/a-mathematical-approach-to-effects-of-ctls-on-cancer-virotherapy-in-the-second-injection-of-virus
#11
A Ashyani, O RabieiMotlagh, H M Mohammadinezhad
This paper proposes a planar delay differential equation for cancer virotherapy. The model simulates the situation in which an oncolytic virus is injected for the second time, and the immune system suppresses the viral infection with a time delay. Our purpose is to provide theoretical conditions so that the therapy can be continued successfully. With the help of the characteristic equation, we examine the singularities and their local stability. Hopf bifurcation is also investigated around the endemic singularity...
May 18, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29782921/flight-duration-and-flight-muscle-ultrastructure-of-unfed-hawk-moths
#12
Bernard W M Wone, Jaika Pathak, Goggy Davidowitz
Flight muscle breakdown has been reported for many orders of insects, but the basis of this breakdown in insects with lifelong dependence on flight is less clear. Lepidopterans show such muscle changes across their lifespans, yet how this change affects the ability of these insects to complete their life cycles is not well documented. We investigated the changes in muscle function and ultrastructure of unfed aging adult hawk moths (Manduca sexta). Flight duration was examined in young, middle-aged, and advanced-aged unfed moths...
May 18, 2018: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29782919/animal-models-to-study-bile-acid-metabolism
#13
REVIEW
Jianing Li, Paul A Dawson
The use of animal models, particularly genetically modified mice, continues to play a critical role in studying the relationship between bile acid metabolism and human liver disease. Over the past 20 years, these studies have been instrumental in elucidating the major pathways responsible for bile acid biosynthesis and enterohepatic cycling, and the molecular mechanisms regulating those pathways. This work also revealed bile acid differences between species, particularly in the composition, physicochemical properties, and signaling potential of the bile acid pool...
May 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29782872/oxyfadichalcone-c-inhibits-melanoma-a375-cell-proliferation-and-metastasis-via-suppressing-pi3k-akt-and-mapk-erk-pathways
#14
Xiaolin Peng, Zhengming Wang, Yang Liu, Xin Peng, Yao Liu, Shan Zhu, Zhe Zhang, Yuling Qiu, Meihua Jin, Ran Wang, Qingying Zhang, Dexin Kong
AIMS: Melanoma remains to be one of the most incurable cancers. Discovery of novel antitumor agent for melanoma therapy is expected. We recently isolated Oxyfadichalcone C from Oxytropis falcate and investigated the anti-proliferative and anti-metastatic activity on human melanoma A375 cells in vitro. MAIN METHODS: Cell viability was determined using MTT assay and soft agar cloning formation assay. The effect of Oxyfadichalcone C on cell cycle distribution and apoptosis were analyzed by flow cytometry...
May 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29782852/atp6v1h-regulates-the-growth-and-differentiation-of-bone-marrow-stromal-cells
#15
Lin Li, Shaoqing Yang, Yanli Zhang, Dongrui Ji, Zuolin Jin, Xiaohong Duan
ATP6V1H encodes subunit H of vacuolar ATPase (V-ATPase) and may regulate osteoclastic function. The deficiency of ATP6V1H caused bone loss in human, mouse and zebrafish. In this report, we identified the mechanisms by which ATP6V1H regulates proliferation and differentiation of bone marrow stromal cells (BMSCs). We found that ATP6V1H was expressed in BMSCs, andAtp6v1h+/- BMSCs exhibited the lower proliferation rate, cell cycle arrest and reduced osteogenic differentiation capacity, as well as the increased adipogenic potentials...
May 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29782832/nup159-weakens-gle1-binding-to-dbp5-but-does-not-accelerate-adp-release
#16
Emily V Wong, Shawn Gray, Wenxiang Cao, Rachel Montpetit, Ben Montpetit, Enrique M De La Cruz
Dbp5, DDX19 in humans, is an essential DEAD-box protein involved in mRNA export, which has also been linked to other cellular processes, including rRNA export and translation. Dbp5 ATPase activity is regulated by several factors, including RNA, the nucleoporin proteins Nup159 and Gle1, and the endogenous small molecule inositol hexakisphosphate (InsP6 ). To better understand how these factors modulate Dbp5 activity and how this modulation relates to in vivo RNA metabolism, a detailed characterization of the Dbp5 mechanochemical cycle in the presence of those regulators individually or together is necessary...
May 18, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29782816/a-new-microsporidium-apotaspora-heleios-n-g-n-sp-from-the-riverine-grass-shrimp-palaemonetes-paludosus-decapoda-caridea-palaemonidae
#17
Yuliya Y Sokolova, Robin M Overstreet
We report a new microsporidium from a key species of the estuarine communities of the Gulf States, the Riverine grass shrimp, Palaemonetes paludosus. A milky-white shrimp was found in the Mobile Bay Delta, a large, oligohaline-freshwater wetland in Alabama, USA. Light microscopy of smears and thick sections of the abdominal tissues demonstrated infection with microsporidian spores enclosed in sporophorous vesicles (SVs) in sets of eight. Broadly oval spores measured 2.9 ± 0.06 x 1.7 ± 0.03 µm (2.5-3.3 x 1...
May 18, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29782795/rna-modulates-the-interaction-between-influenza-a-virus-ns1-and-human-pabp1
#18
Bryan H Arias-Mireles, Cyrus M de Rozieres, Kevin Ly, Simpson Joseph
Non-Structural Protein 1 (NS1) is a multifunctional protein involved in preventing host-interferon response in Influenza A Virus (IAV). Previous studies have indicated that NS1 also stimulates the translation of viral mRNA by binding to conserved sequences in the viral 5'-UTR. Additionally, NS1 binds to Poly (A) Binding Protein (PABP1) and eukaryotic Initiation Factor 4G (eIF4G). The interaction of NS1 with the viral 5'-UTR, PABP1, and eIF4G has been suggested to specifically enhance the translation of viral mRNAs...
May 21, 2018: Biochemistry
https://www.readbyqxmd.com/read/29782624/the-underlying-mechanisms-involved-in-the-protective-effects-of-ischemic-postconditioning
#19
Rong Xie, Jinquan Li, Heng Zhao
Cerebral ischemic postconditioning (PostC) refers to a series of brief ischemia and reperfusion (I/R) cycles applied at the onset of reperfusion following an ischemic event. PostC has been shown to have neuroprotective effects, and represents a promising clinical strategy against cerebral ischemia-reperfusion injury. Many studies have indicated that cerebral PostC can effectively reduce neural cell death, cerebral edema and infarct size, improve cerebral circulation, and relieve inflammation, apoptosis and oxidative stress...
2018: Conditioning medicine
https://www.readbyqxmd.com/read/29782551/structural-insights-on-the-efficient-catalysis-of-hydroperoxide-reduction-by-ohr-crystallographic-and-molecular-dynamics-approaches
#20
Erika Piccirillo, Thiago G P Alegria, Karen F Discola, José R R Cussiol, Renato M Domingos, Marcos A de Oliveira, Leandro de Rezende, Luis E S Netto, Antonia T-do Amaral
Organic hydroperoxide resistance (Ohr) enzymes are highly efficient Cys-based peroxidases that play central roles in bacterial response to fatty acid hydroperoxides and peroxynitrite, two oxidants that are generated during host-pathogen interactions. In the active site of Ohr proteins, the conserved Arg (Arg19 in Ohr from Xylella fastidiosa) and Glu (Glu51 in Ohr from Xylella fastidiosa) residues, among other factors, are involved in the extremely high reactivity of the peroxidatic Cys (Cp) toward hydroperoxides...
2018: PloS One
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