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https://www.readbyqxmd.com/read/28110416/lasiokaurin-derivatives-synthesis-antimicrobial-and-antitumor-biological-evaluation-and-apoptosis-inducing-effects
#1
Da-Hong Li, Ping Hu, Sheng-Tao Xu, Chun-Yan Fang, Shuang Tang, Xin-Yu Wang, Xing-Yan Sun, He Li, Ying Xu, Xiao-Ke Gu, Jin-Yi Xu
Herein, a series of lasiokaurin derivatives were designed and synthesized. All the derivatives together with lasiokaurin and oridonin were tested for their antimicrobial and antiproliferative activity. Compound 16 showed the most promising antimicrobial activity with MICs of 2.0 and 1.0 μg/mL against Gram-Positive bacteria S. aureus and B. subtilis, respectively. All the synthetic lasiokaurin derivatives showed better antiproliferative activity than parent compound lasiokaurin 1. Compound 10 exhibited the strongest cytotoxicity with IC50 values of 0...
January 21, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28110407/in-vitro-performance-of-cad-cam-fabricated-implant-supported-temporary-crowns
#2
Martin Rosentritt, Philipp Raab, Sebastian Hahnel, Matthias Stöckle, Verena Preis
OBJECTIVES: The aim of this study was to investigate the in-vitro performance and fracture resistance of a temporary computer-aided designed and computer-aided manufactured polymethylmethacrylate (CAD/CAM-PMMA) material as implant or tooth-supported single crown with respect to the clinical procedure (permanently bonded/temporarily cemented). MATERIALS AND METHODS: Sixty-four crowns were fabricated on implants or human molar teeth simulating (a) labside procedure on prefabricated titanium-bonding base ([TiBase] implant crown bonded in laboratory, screwed chairside), (b) labside procedure ([LAB] standard abutment and implant crown bonded in laboratory, screwed chairside), (c) chairside procedure ([CHAIR] implant crown bonded to abutment), and (d) reference ([TOOTH] crowns luted on prepared human teeth)...
January 21, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28110283/estimated-generic-prices-of-cancer-medicines-deemed-cost-ineffective-in-england-a-cost-estimation-analysis
#3
Andrew Hill, Christopher Redd, Dzintars Gotham, Isabelle Erbacher, Jonathan Meldrum, Ryo Harada
OBJECTIVES: The aim of this study was to estimate lowest possible treatment costs for four novel cancer drugs, hypothesising that generic manufacturing could significantly reduce treatment costs. SETTING: This research was carried out in a non-clinical research setting using secondary data. PARTICIPANTS: There were no human participants in the study. Four drugs were selected for the study: bortezomib, dasatinib, everolimus and gefitinib. These medications were selected according to their clinical importance, novel pharmaceutical actions and the availability of generic price data...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28110276/photosynthesis-in-c3-c4-intermediate-moricandia-species
#4
Urte Schlüter, Andrea Bräutigam, Udo Gowik, Michael Melzer, Pascal-Antoine Christin, Samantha Kurz, Tabea Mettler-Altmann, Andreas Pm Weber
Evolution of C4 photosynthesis is not distributed evenly in the plant kingdom. Particularly interesting is the situation in the Brassicaceae, because the family contains no C4 species, but several C3-C4 intermediates, mainly in the genus Moricandia Investigation of leaf anatomy, gas exchange parameters, the metabolome, and the transcriptome of two C3-C4 intermediate Moricandia species, M. arvensis and M. suffruticosa, and their close C3 relative M. moricandioides enabled us to unravel the specific C3-C4 characteristics in these Moricandia lines...
January 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28110268/metabolic-and-physiological-adjustment-of-suaeda-maritima-to-combined-salinity-and-hypoxia
#5
Jan H Behr, Alain Bouchereau, Solenne Berardocco, Charlotte E Seal, Timothy J Flowers, Christian Zörb
BACKGROUND AND AIMS: Suaeda maritima is a halophyte commonly found on coastal wetlands in the intertidal zone. Due to its habitat S. maritima has evolved tolerance to high salt concentrations and hypoxic conditions in the soil caused by periodic flooding. In the present work, the adaptive mechanisms of S. maritima to salinity combined with hypoxia were investigated on a physiological and metabolic level. METHODS: To compare the adaptive mechanisms to deficient, optimal and stressful salt concentrations, S...
January 20, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28110264/novel-phyto-derivative-brm270-inhibits-hepatocellular-carcinoma-cells-proliferation-by-inducing-g2-m-phase-cell-cycle-arrest-and-apoptosis-in-xenograft-mice-model
#6
Raj Kumar Mongre, Neelesh Sharma, Simrinder Singh Sodhi, Mrinmoy Ghosh, Amit Kumar Singh, Nameun Kim, Yang Ho Park, Young Gyu Shin, Sung Jin Kim, Zhang Jiao Jiao, Do Luong Huynh, Dong Kee Jeong
Hepatocellular carcinoma (HCC) is a major threat to human health worldwide and development of novel antineoplastic drug is demanding task. BRM270 is a proprietary combination of traditional medicinal herbs, has been shown to be effective against a wide range of stem-like cancer initiating cells (SLCICs). However, the underlying mechanism and antitumor efficacy of BRM270 in human hepatocellular carcinoma (HCC) cells have not been well elucidated till date. Here we studied the tumoricidal effect of BRM270 on human-CD133(+) expressing stem-like HepG-2 and SNU-398 cells...
January 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28110208/inflammatory-pathway-genes-associated-with-inter-individual-variability-in-the-trajectories-of-morning-and-evening-fatigue-in-patients-receiving-chemotherapy
#7
Fay Wright, Marilyn Hammer, Steven M Paul, Bradley E Aouizerat, Kord M Kober, Yvette P Conley, Bruce A Cooper, Laura B Dunn, Jon D Levine, Gail DEramo Melkus, Christine Miaskowski
Fatigue, a highly prevalent and distressing symptom during chemotherapy (CTX), demonstrates diurnal and interindividual variability in severity. Little is known about the associations between variations in genes involved in inflammatory processes and morning and evening fatigue severity during CTX. The purposes of this study, in a sample of oncology patients (N=543) with breast, gastrointestinal (GI), gynecological (GYN), or lung cancer who received two cycles of CTX, were to determine whether variations in genes involved in inflammatory processes were associated with inter-individual variability in initial levels as well as in the trajectories of morning and evening fatigue...
January 19, 2017: Cytokine
https://www.readbyqxmd.com/read/28110198/variation-of-atmospheric-14-co2-and-its-spatial-distribution
#8
Shugang Wu
The atmospheric (14)CO2 is usually presented in the Δ(14)C notation, which cannot reflect its absolute quantity change. This article presents the atmospheric radiocarbon activity concentrations (aacn, reported in mBq/m(3)) in recent years at nine observation stations. The aacn at Schauinsland decrease from 1977 to 1993 but between 1993 and 2003 keeps at a relative steady state. Atmospheric aacns were higher in the northern hemisphere than that in the southern hemisphere. The aacns in the northern hemisphere show clear seasonal cycle with higher value in winter and lower value in summer, while this seasonality is not obvious in the southern hemisphere...
January 19, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28110188/p53-dependent-apoptosis-and-cell-cycle-delay-induced-by-heteroleptic-complexes-in-human-cervical-cancer-cells
#9
Gunjan Sharma, Nishant Kumar Rana, Priya Singh, Pradeep Dubey, Daya Shankar Pandey, Biplob Koch
We previously reported synthesis of novel arene ruthenium (Ru) complexes and evaluated their antitumor activity in murine lymphoma (DL) cells. In this present study we further investigated the mechanism of action of two ruthenium complexes [complex 1 (η6-arene)RuCl(2-pcdpm)] and complex 2 (η6-arene)RuCl(4-mtdpm)] in cervical cancer cell line (HeLa). Our studies demonstrate that anticancer property of these two complexes was due to induction of apoptosis through p53 mediated pathway as well as arrest of cells in G2/M phase of cell cycle...
January 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28110182/a-large-taper-mismatch-is-one-of-the-key-factors-behind-high-wear-rates-and-failure-at-the-taper-junction-of-total-hip-replacements-a-finite-element-wear-analysis
#10
Ariyan Ashkanfar, David J Langton, Thomas J Joyce
Total hip replacement (THR) is one of the most successful orthopaedic surgeries; however, failures can occur due to adverse reactions to wear debris. Recently, a large number of failures linked to the release of metal particles from the taper junction between femoral head and femoral stem have been reported. One possible reason for this may be design variations such as taper mismatches associated with the taper and trunnion angles. Could a large taper mismatch lead to inappropriate contact mechanics and increase relative micromotion and thus wear? In this study, 3D finite element (FE) models of a commercial THR from a perfectly matched interface to large taper mismatches and a wear algorithm were used to investigate the extent of wear that could occur at this junction and identify the optimum tolerances in order to reduce the wear...
January 12, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28110156/maternal-childhood-trauma-postpartum-depression-and-infant-outcomes-avoidant-affective-processing-as-a-potential-mechanism
#11
Karmel W Choi, Kathleen J Sikkema, Bavi Vythilingum, Lut Geerts, Sheila C Faure, Melissa H Watt, Annerine Roos, Dan J Stein
BACKGROUND: Women who have experienced childhood trauma may be at risk for postpartum depression, increasing the likelihood of negative outcomes among their children. Predictive pathways from maternal childhood trauma to child outcomes, as mediated by postpartum depression, require investigation. METHODS: A longitudinal sample of South African women (N=150) was followed through pregnancy and postpartum. Measures included maternal trauma history reported during pregnancy; postpartum depression through six months; and maternal-infant bonding, infant development, and infant physical growth at one year...
January 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28110143/non-denitrifying-polyphosphate-accumulating-organisms-obviate-requirement-for-anaerobic-condition
#12
A Anisa Cokro, Yingyu Law, Rohan B H Williams, Yeshi Cao, Per H Nielsen, Stefan Wuertz
Enhanced biological phosphorus removal (EBPR) is a widely used process in wastewater treatment that requires anaerobic/aerobic or anaerobic/anoxic cycling. Surprisingly, phosphorus (P) release was observed in the presence of nitrate in the anoxic compartment of the activated sludge tank in a full-scale treatment plant with the Modified Ludzack Ettinger configuration. We therefore studied the potential of this full-scale activated sludge community to perform EBPR under anoxic/aerobic cycling. The polyphosphate accumulating organism (PAO) Candidatus Accumulibacter represented 3...
January 3, 2017: Water Research
https://www.readbyqxmd.com/read/28110128/application-of-a-breakthrough-biosorbent-for-removing-heavy-metals-from-synthetic-and-real-wastewaters-in-a-lab-scale-continuous-fixed-bed-column
#13
Atefeh Abdolali, Huu Hao Ngo, Wenshan Guo, John L Zhou, Jian Zhang, Shuang Liang, Soon W Chang, Dinh Duc Nguyen, Yi Liu
A continuous fixed-bed study was carried out utilising a breakthrough biosorbent, specifically multi-metal binding biosorbent (MMBB) for removing cadmium, copper, lead and zinc. The effect of operating conditions, i.e. influent flow rate, metal concentration and bed depth was investigated at pH 5.5±0.1 for a synthetic wastewater sample. Results confirmed that the total amount of metal adsorption declined with increasing influent flow rate and also rose when each metal concentration also increased. The maximum biosorption capacities of 38...
January 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28110065/stochasticity-heterogeneity-and-variance-in-longevity-in-human-populations
#14
Nienke Hartemink, Trifon I Missov, Hal Caswell
Inter-individual variance in longevity (or any other demographic outcome) may arise from heterogeneity or from individual stochasticity. Heterogeneity refers to differences among individuals in the demographic rates experienced at a given age or stage. Stochasticity refers to variation due to the random outcome of demographic rates applied to individuals with the same properties. The variance due to individual stochasticity can be calculated from a Markov chain description of the life cycle. The variance due to heterogeneity can be calculated from a multistate model that incorporates the heterogeneity...
January 18, 2017: Theoretical Population Biology
https://www.readbyqxmd.com/read/28110019/cancer-cell-metabolism-and-mitochondria-nutrient-plasticity-for-tca-cycle-fueling
#15
REVIEW
Cyril Corbet, Olivier Feron
Warburg's hypothesis that cancer cells take up a lot of glucose in the presence of ambient oxygen but convert pyruvate into lactate due to impaired mitochondrial function led to the misconception that cancer cells rely on glycolysis as their major source of energy. Most recent (13)C-based metabolomic studies, including in cancer patients, indicate that cancer cells may also fully oxidize glucose. In addition to glucose-derived pyruvate, lactate, fatty acids and amino acids supply substrates to the TCA cycle to sustain mitochondrial metabolism...
January 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28109982/altered-glutamate-metabolism-contributes-to-antiepileptogenic-effects-in-the-progression-from-focal-seizure-to-generalized-seizure-by-low-frequency-stimulation-in-the-ventral-hippocampus
#16
Hong-Liu Sun, Wei Zhu, Yu-Rong Zhang, Xiao-Hong Pan, Jun-Ru Zhang, Xiang-Ming Chen, Yu-Xia Liu, Shu-Cui Li, Qiao-Yun Wang, Da-Ping Deng
As a promising method for treating intractable epilepsy, the inhibitory effect of low-frequency stimulation (LFS) is well known, although its mechanisms remain unclear. Excessive levels of cerebral glutamate are considered a crucial factor for epilepsy. Therefore, we designed experiments to investigate the crucial parts of the glutamate cycle. We evaluated glutamine synthetase (GS, metabolizes glutamate), glutaminase (synthesizes glutamate), and glutamic acid decarboxylase (GAD, a γ-aminobutyric acid [GABA] synthetase) in different regions of the brain, including the dentate gyrus (DG), CA3, and CA1 subregions of the hippocampus, and the cortex, using western blots, immunohistochemistry, and enzyme activity assays...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28109940/proteome-response-of-fish-under-multiple-stress-exposure-effects-of-pesticide-mixtures-and-temperature-increase
#17
Allison Gandar, Pascal Laffaille, Nathalie Marty-Gasset, Didier Viala, Caroline Molette, Séverine Jean
Aquatic systems can be subjected to multiple stressors, including pollutant cocktails and elevated temperature. Evaluating the combined effects of these stressors on organisms is a great challenge in environmental sciences. To the best of our knowledge, this is the first study to assess the molecular stress response of an aquatic fish species subjected to individual and combined pesticide mixtures and increased temperatures. For that, goldfish (Carassius auratus) were acclimated to two different temperatures (22 and 32°C) for 15 days...
January 15, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28109914/anti-inflammatory-and-toxicological-evaluation-of-essential-oil-from-piper-glabratum-leaves
#18
Lidiane Schultz Branquinho, Joyce Alencar Santos, Claudia Andrea Lima Cardoso, Jonas da Silva Mota, Ubirajara Lanza Junior, Cândida Aparecida Leite Kassuya, Arielle Cristina Arena
ETHNOPHARMACOLOGICAL RELEVANCE: Although some of the species of the genus Piper exhibit interesting biological properties, studies on Piper glabratum Kunth are very limited. AIM OF THE STUDY: This study investigated the anti-inflammatory activity and the toxicological profile of the essential oil from P. glabratum leaves (OEPG) in mice. MATERIALS AND METHODS: The acute toxicity of OEPG was evaluated by oral administration to female mice as single doses of 500, 1000, 2000 or 5000mg/kg/body weight...
January 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28109906/succinate-in-the-cancer-immune-cycle
#19
Shuai Jiang, Wei Yan
Succinate is an important intermediate of the tricarboxylic acid (TCA) cycle. In mitochondria, it plays a crucial role in generating adenosine triphosphate. Succinate metabolism is also intertwined with the metabolism of other metabolites and with the "GABA shunt" of the glutamine pathway. Recently, it has become increasingly apparent that the roles of succinate extend into the realms of immunity and cancer. Succinate is a key modulator of the hypoxic response, an important player in tumorigenesis; succinate is also involved in protein succinylation, a novel posttranslational modification pathway...
January 18, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28109900/microcystin-lr-retards-gonadal-maturation-through-disrupting-the-growth-hormone-insulin-like-growth-factors-system-in-zebrafish
#20
Jie Hou, Yujing Su, Wang Lin, Honghui Guo, Ping Xie, Jun Chen, Zemao Gu, Li Li
Recent studies have documented that microcystins (MCs) have potential toxic effects on growth and reproduction in fish. However, no systematic data exist on whether MCs cause gonadal development retardation through disrupting the growth hormone/insulin-like growth factors (GH/IGFs) system. To this end, zebrafish hatchlings (5 d post-fertilization) were exposed to 0, 0.3, 3 and 30µg/L microcystin-LR (MC-LR) for 90 d until they reached sexual maturity. Life-cycle exposure to MC-LR caused delayed ovarian maturation and sperm development along with ultrapathological lesions in the brain and liver...
January 18, 2017: Ecotoxicology and Environmental Safety
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