keyword
https://read.qxmd.com/read/38495601/chatgpt-and-transcranial-direct-current-stimulation-for-chronic-pain
#21
EDITORIAL
Edson Silva-Filho, Rodrigo Pegado
OBJECTIVE: We aimed to open a discussion about the integration of artificial intelligence (AI) in science and clinical practice, specifically with regard to the use of transcranial direct current stimulation (tDCS) as a technique for managing chronic pain. MAIN POINTS OF DISCUSSION: To analyze the responses generated by ChatGPT and the best literature about tDCS, we formulated three questions. The answers from ChatGPT, compared to the guidelines and Cochrane review, showed that AI can be a potential strategy to help clinicians and researchers...
2024: Innovations in Clinical Neuroscience
https://read.qxmd.com/read/38495136/discovery-of-new-%C3%AE-glucosides-antiglycation-agent-and-in-silico-study-of-2-3-4-dihydroxyphenyl-7-8-dihydroxy-3-methoxy-4h-chromen-4-one-isolated-from-pistacia-chinensis
#22
JOURNAL ARTICLE
Tareq Abu-Izneid, Abdur Rauf, Zuneera Akram, Saima Naz, Abdul Wadood, Naveed Muhammad, Chandni Hayat, Yahya S Al-Awthan, Omar S Bahattab
Pistacia chinensis is locally practiced for treating diabetes, pain, inflammation, and erectile dysfunction. Therefore, the current studies subjected the crude extract/fractions and the isolated compound (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-3-methoxy-4H-chromen-4-one) to α-glucosidase inhibitor and anti-glycation activities. The development of long-term complications associated with diabetes is primarily caused by chronic hyperglycemia. Regarding α-glucosidase, the most significant inhibitory effect was observed with compound 1 (93...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38495065/management-of-neuropathic-pain-with-neurectomy-combined-with-dermal-sensory-regenerative-peripheral-nerve-interface-ds-rpni
#23
REVIEW
Geoffrey E Hespe, David L Brown
Neuropathic pain affects a large percentage of the U.S. population and leads to tremendous morbidity. Numerous nonsurgical and surgical treatments have been utilized to try and manage neuropathic pain with varying degrees of success. Recent research investigating ways to improve prosthetic control have identified new mechanisms for preventing neuromas in both motor and sensory nerves with free muscle and dermal grafts, respectively. These procedures have been used to treat chronic neuropathic pain in nonamputees, as well, in order to reduce failure rates found with traditional neurectomy procedures...
February 2024: Seminars in Plastic Surgery
https://read.qxmd.com/read/38495062/regenerative-peripheral-nerve-interface-surgery-for-the-management-of-chronic-posttraumatic-neuropathic-pain
#24
REVIEW
Jennifer C Lee, Stephen W P Kemp, Theodore A Kung
Chronic pain resulting from peripheral nerve injury remains a common issue in the United States and affects 7 to 10% of the population. Regenerative Peripheral Nerve Interface (RPNI) surgery is an innovative surgical procedure designed to treat posttraumatic neuropathic pain, particularly when a symptomatic neuroma is present on clinical exam. RPNI surgery involves implantation of a transected peripheral nerve into an autologous free muscle graft to provide denervated targets to regenerating axons. RPNI surgery has been found in animal and human studies to be highly effective in addressing postamputation pain...
February 2024: Seminars in Plastic Surgery
https://read.qxmd.com/read/38495000/associations-between-cognitive-test-scores-and-pain-tolerance-the-troms%C3%A3-study
#25
JOURNAL ARTICLE
Tonje Anita Melum, Ólöf A Steingrímsdóttir, Henrik B Jacobsen, Bente Johnsen, Audun Stubhaug, Henrik Schirmer, Ellisiv B Mathiesen, Christopher S Nielsen
OBJECTIVES: Previous studies have suggested that experimental pain sensitivity is associated with cognitive function. The aim of this study is to assess this relationship in a large population-based sample. METHODS: We included 5,753 participants (aged 40-84 years) from the seventh wave of the population-based Tromsø Study who had been examined with cognitive tests and experimental pain assessments, and for whom information on covariates were available. Cox regression models were fitted using standardized scores on cognitive tests (12-word immediate recall test, digit symbol coding test, and Mini-Mental State Examination [MMS-E]) as the independent variable and cold pressor or cuff pressure pain tolerance as the dependent variables...
January 1, 2024: Scandinavian Journal of Pain
https://read.qxmd.com/read/38494735/ketogenic-diet-alleviates-mechanical-allodynia-in-the-models-of-inflammatory-and-neuropathic-pain-in-male-mice
#26
JOURNAL ARTICLE
Kei Eto, Masanori Ogata, Yoshitaka Toyooka, Toru Hayashi, Hitoshi Ishibashi
Inflammation is involved in the induction of chronic inflammatory and neuropathic pain. Moreover, the ketogenic diet, a high-fat, low-carbohydrate, and adequate protein diet, has an anti-inflammatory effect. Thus, we hypothesized that a ketogenic diet has a therapeutic effect on both types of chronic pain. In the present study, we investigated the effect of a ketogenic diet on mechanical allodynia, a chronic pain symptom, in formalin-induced chronic inflammatory pain and nerve injury-induced neuropathic pain models using adult male mice...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38494402/health-coaching-improves-physical-activity-disability-and-pain-in-adults-with-chronic-non-cancer-pain-a-systematic-review
#27
JOURNAL ARTICLE
Talia Barnet-Hepples, Amabile Dario, Juliana Oliveira, Christopher Maher, Anne Tiedemann, Anita Amorim
QUESTION: What is the effect of health coaching on physical activity, disability, pain and quality of life compared with a non-active control in adults with chronic non-cancer pain? DESIGN: Systematic review and meta-analysis of randomised controlled trials. Evidence was synthesised as standardised mean differences with 95% confidence intervals using random-effects models. Risk of bias was assessed using the revised Cochrane risk of bias tool. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to determine evidence certainty...
March 16, 2024: Journal of Physiotherapy
https://read.qxmd.com/read/38494346/the-problem-of-pain-in-lupus-epidemiological-profiles-of-patients-attending-multidisciplinary-pain-clinics
#28
JOURNAL ARTICLE
Tiffany E Jiang, Alissa P Pascual, Nathan Le, Thy B Nguyen, Sean Mackey, Beth D Darnall, Julia F Simard, Titilola Falasinnu
INTRODUCTION: Patients with systemic lupus erythematosus (SLE) bear a significant burden of pain. We aimed to identify factors that distinguish patients with SLE referred to comprehensive pain clinics and those who are not. Characterizing this patient population will identify unmet needs in SLE management and inform efforts to improve pain care in rheumatology. METHODS: Among patients with SLE with ≥2 rheumatology clinic visits in a large hospital system from 1998 to 2023 (n = 1319), we examined factors that distinguished those who had at least one visit to multidisciplinary pain clinics (n = 77, 5...
March 16, 2024: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://read.qxmd.com/read/38494195/the-clinical-value-of-intelligent-wound-measurement-devices-in-patients-with-chronic-wounds-a-scoping-review
#29
JOURNAL ARTICLE
Yujie Wu, Liping Wu, Mingfeng Yu
Chronic wounds are common in clinical practice, with long treatment cycle and high treatment cost. Changes in wound area can well predict the effectiveness of treatment and the possibility of healing. Therefore, continuous wound monitoring and evaluation are particularly important. Traditional manual wound measurement tends to overestimate wound area. Recently, various intelligent wound measurement devices have been introduced into clinical practice. This review aims to summarise the reliability, validity, types and measurement principles of different intelligent wound measurement devices, so as to analyse the clinical value and application prospect...
March 2024: International Wound Journal
https://read.qxmd.com/read/38494111/predictive-factors-of-postoperative-pain-in-patients-with-tibiotalocalcaneal-arthrodesis-with-an-intramedullary-nail-a-retrospective-review
#30
JOURNAL ARTICLE
Bryanna D Vesely, Jennifer Kipp, Gregory Russell, Lindsay LeSavage, Hayden Hoffler, Ashleigh W Medda, Aaron T Scott
Tibiotalocalcaneal arthrodesis has been shown in literature to have good results in regards to low complication rates and deformity correction. While previous studies have investigated functional outcomes and complication rates, no large-scale studies have looked at pain outcomes. The present study used a retrospective review of 154 extremities to analyze how a patient's comorbidities and characteristics influence pain outcomes following a tibiotalocalcaneal arthrodesis. The present study found an average change of pain from 7...
March 15, 2024: Journal of Foot and Ankle Surgery
https://read.qxmd.com/read/38494091/senolytic-therapeutics-an-emerging-treatment-modality-for-osteoarthritis
#31
REVIEW
Md Meraj Ansari, Mrinmoy Ghosh, Dong-Sun Lee, Young-Ok Son
Osteoarthritis (OA), a chronic joint disease affecting millions of people aged over 65 years, is the main musculoskeletal cause of diminished joint mobility in the elderly. It is characterized by lingering pain and increasing deterioration of articular cartilage. Aging and accumulation of senescent cells (SCs) in the joints are frequently associated with OA. Apoptosis resistance; irreversible cell cycle arrest; increased p16INK4a expression, secretion of senescence-associated secretory phenotype factors, senescence-associated β-galactosidase levels, secretion of extracellular vesicles, and levels of reactive oxygen and reactive nitrogen species; and mitochondrial dysregulation are some common changes in cellular senescence in joint tissues...
March 15, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38493828/laparoscopic-multibipolar-radiofrequency-myolysis-for-symptomatic-myomas-in-10-steps
#32
JOURNAL ARTICLE
Raphael Niddam, Antoine Netter, Blandine Courbière, Aubert Agostini, Laura Miquel
OBJECTIVE: To describe a minimal invasive 10-step technique of laparoscopic multibipolar radiofrequency myolysis for symptomatic myomas. DESIGN: A step-by-step video demonstration of the technique SETTING: A woman with symptomatic FIGO 5 myoma of 60 mm of diameter, confirmed by magnetic resonance imaging. The patient included in this video gave consent for publication of the video and posting of the video online including social media, the journal website, scientific literature websites (such as PubMed, ScienceDirect, Scopus, etc...
March 15, 2024: Journal of Minimally Invasive Gynecology
https://read.qxmd.com/read/38493580/isoliquiritigenin-reduces-experimental-autoimmune-prostatitis-by-facilitating-nrf2-activation-and-suppressing-the-nlrp3-inflammasome-pathway
#33
JOURNAL ARTICLE
Rui Feng, Tong Meng, Xiaohu Zhao, Weidong Yu, Haolin Li, Zicheng Wang, Jing Chen, Cheng Yang
BACKGROUND: Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) lead to severe irritation and impaired sperm quality in males. However, current therapeutic options often fail to achieve satisfactory effects. Consequently, the investigation of novel treatment strategies or remedies holds substantial clinical importance. As a flavonoid monomer, isoliquiritigenin (ISL) has been shown to possess anti-inflammatory activity, especially in several chronic nonspecific-inflammatory conditions...
March 16, 2024: Molecular Immunology
https://read.qxmd.com/read/38493566/the-prevalence-of-cannabis-use-disorders-in-people-who-use-medicinal-cannabis-a-systematic-review-and-meta-analysis
#34
REVIEW
Danielle Dawson, Daniel Stjepanović, Valentina Lorenzetti, Christy Cheung, Wayne Hall, Janni Leung
BACKGROUND: The prevalence of cannabis use disorders (CUDs) in people who use cannabis recreationally has been estimated at 22%, yet there is a dearth of literature exploring CUDs among people who use medicinal cannabis. We aimed to systematically review the prevalence of CUDs in people who use medicinal cannabis. METHODS: In our systematic review and meta-analysis, we followed PRISMA guidelines and searched three databases (PsychInfo, Embase and PubMed) to identify studies examining the prevalence of CUDs in people who use medicinal cannabis...
March 8, 2024: Drug and Alcohol Dependence
https://read.qxmd.com/read/38493551/mesh-less-laparoscopic-extraperitoneal-linear-suspension-treatment-of-vaginal-vault-prolapse
#35
JOURNAL ARTICLE
Wenhui Wang, Haiyan Liang, Huan Yu, Chunhong Rong, Yuxiao Dong, Ming Xue, Xiaodie Liu, Jing Liang, Bin Ling
OBJECTIVES: To report the results of a mesh-less laparoscopic extraperitoneal linear suspension technique for the treatment of post-hysterectomy vaginal vault prolapse (PHVP). STUDY DESIGN: A retrospective observational study was conducted collecting medical records of 41 patients with symptomatic PHVP treated between November 2017 to November 2019 in Gynecologic department of China-Japan Friendship Hospital. All patients had Pelvic Organ Prolapse Quantification (POP-Q) scores indicating stage 3-4 PHVP and underwent mesh-less laparoscopic extraperitoneal linear suspension...
February 23, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38493143/low-intensity-pulsed-ultrasound-delays-the-progression-of-osteoarthritis-by-regulating-the-yap-ripk1-nf-%C3%AE%C2%BAb-axis-and-influencing-autophagy
#36
JOURNAL ARTICLE
Chunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo, Tao Xu
BACKGROUND: Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even disability. The risk factors for OA include genetics, gender, trauma, obesity, and age. Unfortunately, due to limited understanding of its pathological mechanism, there are currently no effective drugs or treatments to suspend the progression of osteoarthritis. In recent years, some studies found that low-intensity pulsed ultrasound (LIPUS) may have a positive effect on osteoarthritis...
March 16, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38493079/the-relationship-between-pregnancy-and-temporomandibular-disorder-tmd-through-diagnostic-criteria-for-temporomandibular-disorders-dc-tmd-axis-ii-evaluation-a-case-control-cross-sectional-study
#37
JOURNAL ARTICLE
Giuseppe Minervini, Maria Maddalena Marrapodi, Marco La Verde, Aida Meto, Yuliia Siurkel, Marco Cicciù, Diana Russo
INTRODUCTION: This study focuses on temporomandibular disorders (TMDs), which affect the temporomandibular joint and related muscles and have multiple causes. Recent studies have examined the connection between menstrual cycles, estrogen levels, and TMDs, but results are inconsistent, highlighting the need for more research. The aim is to explore the prevalence of TMDs in pregnant women and consider how hormonal changes during pregnancy might influence these disorders. METHODS: In this cross-sectional case-control study, we compared 32 pregnant women with 35 non-pregnant women...
March 16, 2024: BMC Oral Health
https://read.qxmd.com/read/38492991/online-learning-to-improve-nurses-knowledge-attitudes-and-self-efficacy-about-managing-postoperative-pain-in-older-adults
#38
JOURNAL ARTICLE
Phichpraorn Youngcharoen, Chayada Piyakhachornrot
BACKGROUND: Older adults undergoing total knee arthroplasty may develop chronic pain without effective postoperative pain management. Increasing nurses' knowledge, changing their attitudes, and developing their pain management self-efficacy could improve the effectiveness of pain management. AIM: To determine the effectiveness of an online learning program to help registered nurses to manage postoperative pain in older adults undergoing total knee arthroplasty. DESIGN: A quasi-experimental pre-test-post-test design with intervention and control groups...
March 15, 2024: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://read.qxmd.com/read/38492990/fatigue-and-depressive-mood-in-chronic-low-back-pain
#39
JOURNAL ARTICLE
Anitha Saravanan, Prempreet Bajaj, Herbert L Matthews, Dina Tell, Angela Starkweather, Linda Janusek
PURPOSE: Fatigue is prevalent, problematic, and co-occurs in chronic low back pain. When left untreated, fatigue can increase depressive mood, and intensify pain burden and disability in patients with chronic low back pain. The purpose of this study was to examine the relationship of fatigue to depressive mood, pain severity, and pain interference in patients with chronic low back pain. DESIGN AND METHODS: A cross-sectional design was used to enroll and evaluate adults (n = 67) with chronic low back pain (>6 months) during their visit to an outpatient pain clinic...
March 15, 2024: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://read.qxmd.com/read/38492895/olfactory-ensheathing-cells-as-candidate-cells-for-chronic-pain-treatment
#40
REVIEW
Mei-Chen Liu, Qing-Fa Guo, Wei-Wei Zhang, Hong-Liang Luo, Wen-Jun Zhang, Hai-Jun Hu
Chronic pain is often accompanied by tissue damage and pain hypersensitivity. It easily relapses and is challenging to cure, which seriously affects the patients' quality of life and is an urgent problem to be solved. Current treatment methods primarily rely on morphine drugs, which do not address the underlying nerve injury and may cause adverse reactions. Therefore, in recent years, scientists have shifted their focus from chronic pain treatment to cell transplantation. This review describes the classification and mechanism of chronic pain through the introduction of the characteristics of olfactory ensheathing cells (OECs), an in-depth discussion of special glial cells through the phagocytosis of nerve debris, receptor-ligand interactions, providing nutrition, and other inhibition of neuroinflammation, and ultimately supporting axon regeneration and mitigation of chronic pain...
March 14, 2024: Journal of Chemical Neuroanatomy
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