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https://www.readbyqxmd.com/read/29929183/pre-clinical-evaluation-of-novel-mucoadhesive-bilayer-patches-for-local-delivery-of-clobetasol-17-propionate-to-the-oral-mucosa
#1
H E Colley, Z Said, M E Santocildes-Romero, S R Baker, K D'Apice, J Hansen, L Siim Madsen, M H Thornhill, P V Hatton, C Murdoch
Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are chronic inflammatory conditions often characterised by erosive and/or painful oral lesions that have a considerable impact on quality of life. Current treatment often necessitates the use of steroids in the form of mouthwashes, creams or ointments, but these are often ineffective due to inadequate drug contact times with the lesion. Here we evaluate the performance of novel mucoadhesive patches for targeted drug delivery. Electrospun polymeric mucoadhesive patches were produced and characterised for their physical properties and cytotoxicity before evaluation of residence time and acceptability in a human feasibility study...
June 14, 2018: Biomaterials
https://www.readbyqxmd.com/read/29929016/intralesional-steroid-injections-for-recurrent-vaginal-strictures
#2
Jessica Shim, Maggie Dwiggins, Veronica Gomez-Lobo
BACKGROUND: Postoperative complications after transverse vaginal septum excision include stricture formation. The purpose of this report is to describe use of intralesional corticosteroid injections for vaginal strictures. CASE: A 32-year-old gravida-0 with history of transverse vaginal septum and recurrent strictures presented for follow-up of chronic pelvic pain. After her fourth septum revision, the patient underwent a total of seven triamcinolone injections at the septum tissue...
June 18, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29928887/lipopolysaccharide-mediated-inflammatory-priming-potentiates-painful-post-traumatic-trigeminal-neuropathy
#3
Yves Boucher, Nathan Moreau, Annie Mauborgne, Wisam Dieb
We explored the molecular and behavioral effects of a perineural Lipopolysaccharide (LPS)-mediated inflammatory priming on the development and maintenance of painful post-traumatic trigeminal neuropathy (PPTTN) following infra-orbital nerve chronic constriction injury (CCI-IoN) in rats. Rats were pretreated with repetitive perineural injections in the vicinity of the IoN of either LPS or vehicle (Vhcl) before being submitted to CCI-IoN. Orofacial pain-like behaviors (response to Von Frey Filament testing and spontaneous isolated face grooming) were measured during the period of LPS injections (three weeks) and following CCI-IoN surgery (two weeks)...
June 18, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29928886/chronic-sleep-restriction-increases-pain-sensitivity-over-time-in-a-periaqueductal-gray-and-nucleus-accumbens-dependent-manner
#4
Natalia Fantin Sardi, Mayla Ketlyn Lazzarim, Vinicius Augusto Guilhen, Renata Scuzziatto Marcílio, Priscila Shizue Natume, Thainá Caldeiras Watanabe, Marcelo de Meira Santos Lima, Glaucia Tobaldini, Luana Fischer
Painful conditions and sleep disturbances are major public health problems worldwide and one directly affects the other. Sleep loss increases pain prevalence and severity; while pain disturbs sleep. However, the underlying mechanisms are largely unknown. Here we asked whether chronic sleep restriction for 6 h daily progressively increases pain sensitivity and if this increase is reversed after two days of free sleep. Also, whether the pronociceptive effect of chronic sleep restriction depends on the periaqueductal grey and on the nucleus accumbens, two key regions involved in the modulation of pain and sleep-wake cycle...
June 18, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29928864/definition-development-and-prevalence-of-new-persistent-opioid-use-following-hysterectomy
#5
Carolyn W Swenson, Neil S Kamdar, Kristian Seiler, Daniel M Morgan, Paul Lin, Sawsan As-Sanie
BACKGROUND: Opioids used for postoperative pain control after surgery have been associated with an increased risk of chronic opioid use. Hysterectomy is the most common major gynecologic procedure in the United States; however, we lack a data-driven definition of new persistent opioid use specific to hysterectomy. OBJECTIVE: 1) Determine a data-driven definition of new persistent opioid use among opioid naïve women undergoing hysterectomy; 2) Determine the prevalence of and risk factors for new persistent opioid use...
June 18, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29928613/development-of-a-clinically-relevant-symptom-index-to-assess-patients-with-chronic-orchialgia-chronic-scrotal-content-pain
#6
Alan Scott Polackwich, Hans Chin Arora, Jianbo Li, Laurence Levine, Bayo Tojuola, Sijo Parekattil, Daniel A Shoskes
Background: The purpose of this study was to develop a candidate symptom index for men with an established diagnosis of chronic orchialgia. Methods: Based on interviews with patients and providers, we developed a 70-item questionnaire that focused on seven areas of orchialgia symptoms: pain, location, urinary symptoms, sexual dysfunction, medical history and quality of life (QOL) impact. The questionnaire was completed by patients at two medical centers. Cluster analysis was performed with the software package R (3...
May 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29928200/chronic-prurigo-an-unusual-presentation-of-hodgkin-lymphoma
#7
Shireen Dumont, Marc Péchère, Laurence Toutous Trellu
Background: Prurigo nodularis is a condition of unknown origin defined by papulonodular eruption and intense pruritus. Hodgkin lymphoma often presents nonspecific initial symptoms. An association between systemic malignancy and cutaneous manifestations has long been documented. We report a case of prurigo nodularis as a first presentation of Hodgkin lymphoma. Case: A 35-year-old woman presented with a 2-year history of pruritus. Previously diagnosed with bedbugs, the pruritus persisted even after insect eradication, with the appearance of papulonodular lesions consistent with chronic prurigo...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29928122/the-effect-of-evening-primrose-oil-on-fatigue-and-quality-of-life-in-patients-with-multiple-sclerosis
#8
Nastaran Majdinasab, Foroogh Namjoyan, Mohsen Taghizadeh, Hamid Saki
Background: Multiple sclerosis (MS) is a chronic progressive and inflammatory disease of the central nervous system that is characterized by demyelination in the central nervous system. In regard to the prevalence of diseases and enormous costs imposed on society and the health system, finding a way to stop the progression of the disease using drugs with fewer side effects seems a serious sanitation issue to the health of the international community. This study aimed to evaluate the effect of evening primrose oil (EPO) on fatigue and quality of life in patients with MS...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29927949/snps-in-inflammatory-genes-ccl11-ccl4-and-mefv-in-a-fibromyalgia-family-study
#9
Zhifang Zhang, Jinong Feng, Allen Mao, Keith Le, Deirdre La Placa, Xiwei Wu, Jeffrey Longmate, Claudia Marek, R Paul St Amand, Susan L Neuhausen, John E Shively
BACKGROUND: Fibromyalgia (FM) is a chronic pain syndrome with a high incidence in females that may involve activation of the immune system. We performed exome sequencing on chemokine genes in a region of chromosome 17 identified in a genome-wide family association study. METHODS AND FINDINGS: Exome sequence analysis of 100 FM probands was performed at 17p13.3-q25 followed by functional analysis of SNPs found in the chemokine gene locus. Missense SNPs (413) in 17p13...
2018: PloS One
https://www.readbyqxmd.com/read/29927872/nutritional-considerations-in-pediatric-pancreatitis-a-position-paper-from-the-nasphan-pancreas-committee-and-esphan-cystic-fibrosis-pancreas-working-group
#10
Maisam Abu-El-Haija, Aliye Uc, Steven L Werlin, Alvin Jay Freeman, Miglena Georgieva, Danijela Jojkić-Pavkov, Daina Kalnins, Brigitte Kochavi, Bart G P Koot, Stephanie Van Biervliet, Jaroslaw Walkowiak, Michael Wilschanski, Veronique D Morinville
OBJECTIVES: Wide variations exist in how physicians manage the nutritional aspects of children affected by acute pancreatitis (AP), acute recurrent pancreatitis (ARP), and chronic (CP) pancreatitis. Better consensus for optimal management is needed. METHODS: This consensus statement on nutrition in pediatric pancreatic diseases was developed through a joint ESPGHAN-NASPGHAN working group that performed an evidence-based search of the literature on nutrition in AP, ARP, and CP with a focus on pediatrics...
July 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29927768/an-update-on-the-basic-and-clinical-science-of-ketamine-analgesia
#11
Lisa V Doan, Jing Wang
OBJECTIVE: In the context of the current opioid epidemic, there has been a renewed interest in the use of ketamine as an analgesic agent. METHODS: We have reviewed ketamine analgesia. RESULTS: Ketamine is well-known as an antagonist for N-methyl-D-aspartate receptors. In addition, it can regulate the function of opioid receptors and sodium channels. Ketamine also increases signaling through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors...
June 20, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29927633/imaging-findings-in-essure-related-complications
#12
Hachem Djeffal, Marie Blouet, Anne-Cécile Pizzoferrato, Delphine Vardon, Frederique Belloy, Jean-Pierre Pelage
Tubal sterilization with Essure inserts has become a prevalent alternative to laparoscopic sterilization because of its minimal invasiveness. It is a well-tolerated ambulatory procedure that provides reliable permanent contraception without the risks associated with laparoscopic surgery and general anesthesia. Correct positioning of the Essure device is necessary to achieve the fibrotic reaction induced by the polyethylene terephthalate fibers, subsequently resulting in tubal occlusion usually within 3 months...
June 21, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29927422/-prognostic-models-of-the-severity-of-acute-dynamic-pain-on-the-first-postoperative-day-and-the-likelihood-of-chronic-postoperative-pain-in-spine-surgery
#13
P G Genov, V Kh Timerbaev, N S Dolgasheva, A A Efanov, A A Grin', O Yu Rebrova
The risk factors for acute pain as well as chronic pain syndrome (CPS) in spine surgery have not been defined to date. PURPOSE: To define the prognostic parameters of acute pain severity and the risk of CPS in patients operated on for spinal diseases and injuries. MATERIAL AND METHODS: The study included 291 patients operated on for degenerative diseases and injuries of the spine at the Sklifosovsky Research Institute of Emergency Medicine in 2010-2016. Sociodemographic and clinical data and the psychological status of patients were evaluated...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29926951/periodontitis-consensus-report-of-workgroup-2-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#14
Panos N Papapanou, Mariano Sanz, Nurcan Buduneli, Thomas Dietrich, Magda Feres, Daniel H Fine, Thomas F Flemmig, Raul Garcia, William V Giannobile, Filippo Graziani, Henry Greenwell, David Herrera, Richard T Kao, Moritz Kebschull, Denis F Kinane, Keith L Kirkwood, Thomas Kocher, Kenneth S Kornman, Purnima S Kumar, Bruno G Loos, Eli Machtei, Huanxin Meng, Andrea Mombelli, Ian Needleman, Steven Offenbacher, Gregory J Seymour, Ricardo Teles, Maurizio S Tonetti
A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and are further characterized based on a multi-dimensional staging and grading system. Staging is largely dependent upon the severity of disease at presentation as well as on the complexity of disease management, while grading provides supplemental information about biological features of the disease including a history-based analysis of the rate of periodontitis progression; assessment of the risk for further progression; analysis of possible poor outcomes of treatment; and assessment of the risk that the disease or its treatment may negatively affect the general health of the patient...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926915/the-characteristics-of-women-recommended-a-laparoscopy-for-chronic-pelvic-pain-at-a-tertiary-institution
#15
Kelly L Mirowska-Allen, Megan Sewell, Samantha Mooney, Peter Maher, Damian J Ianno, Sonia R Grover
BACKGROUND: Clinician and patient factors impact on the management of chronic pelvic pain (CPP) with medical, surgical or combined approaches possible, although none have proven superior. AIMS: To understand the characteristics of women offered laparoscopic pelvic surgery for CPP. MATERIALS AND METHODS: We performed an observational study of women referred with CPP. They were asked to complete a study questionnaire regarding their symptoms, medical history, quality of life and pain catastrophisation...
June 21, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29926490/periodontitis-consensus-report-of-workgroup-2-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#16
Panos N Papapanou, Mariano Sanz, Nurcan Buduneli, Thomas Dietrich, Magda Feres, Daniel H Fine, Thomas F Flemmig, Raul Garcia, William V Giannobile, Filippo Graziani, Henry Greenwell, David Herrera, Richard T Kao, Moritz Kebschull, Denis F Kinane, Keith L Kirkwood, Thomas Kocher, Kenneth S Kornman, Purnima S Kumar, Bruno G Loos, Eli Machtei, Huanxin Meng, Andrea Mombelli, Ian Needleman, Steven Offenbacher, Gregory J Seymour, Ricardo Teles, Maurizio S Tonetti
A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and are further characterized based on a multi-dimensional staging and grading system. Staging is largely dependent upon the severity of disease at presentation as well as on the complexity of disease management, while grading provides supplemental information about biological features of the disease including a history-based analysis of the rate of periodontitis progression; assessment of the risk for further progression; analysis of possible poor outcomes of treatment; and assessment of the risk that the disease or its treatment may negatively affect the general health of the patient...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29926357/preperitoneal-bupivacaine-infiltration-reduces-postoperative-opioid-consumption-acute-pain-and-chronic-postsurgical-pain-after-bariatric-surgery-a-randomized-controlled-trial
#17
Saskia L Boerboom, Ann de Haes, Lianne Vd Wetering, Edo O Aarts, Ignace M C Janssen, Jose W Geurts, Ed T Kamphuis
INTRODUCTION: A multimodal pain treatment including local anesthetics is advised for perioperative analgesia in bariatric surgery. Due to obesity, bariatric surgery patients are at risk of respiratory complications. Opioid consumption is an important risk factor for hypoventilation. Furthermore, acute postoperative pain is an important risk factor for chronic postsurgical pain. In this study, we aimed to evaluate whether preperitoneal anesthesia with bupivacaine would reduce pain and opioid consumption after bariatric surgery...
June 20, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29926144/lappaconitine-a-c18-diterpenoid-alkaloid-exhibits-antihypersensitivity-in-chronic-pain-through-stimulation-of-spinal-dynorphin-a-expression
#18
Ming-Li Sun, Jun-Ping Ao, Yi-Rui Wang, Qian Huang, Teng-Fei Li, Xin-Yan Li, Yong-Xiang Wang
Lappaconitine is a representative C18-diterpenoid alkaloid extracted from Aconitum sinomontanum Nakai and has been prescribed as a pain relief medicine in China for more than 30 years. This study evaluated its antihypersensitivity activity in the rat models of neuropathic and cancer pains and explored its underlying mechanisms. Subcutaneous injection of cumulative doses of lappaconitine produced dose-dependent mechanical antiallodynia and thermal antihyperalgesia in spinal nerve ligation-induced neuropathic rats...
June 20, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29926066/-dexmedetomidine-suppresses-mechanical-allodynia-by-inhibiting-hyperpolarization-activated-inward-current
#19
Fang Zhang, Rui Gu, Ya-Xing Feng, Yao-Lei Zhang, Wei Li, Ting Li, Ming Zhang
The purpose of the present study was to investigate the effects of dexmedetomidine (DEX) on neuropathic pain in the chronic compression of dorsal root ganglion (CCD) rat model and the underlying mechanism. Pain behavioral tests were applied to observe the effects of DEX on mechanical allodynia in Sprague Dawley (SD) rats. Whole cell patch clamp was used to observe the influence of DEX on excitability and hyperpolarization-activated inward current (Ih ) of C- and Aδ -type dorsal root ganglion (DRG) neurons...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29925724/influence-of-regional-anesthesia-on-the-rate-of-chronic-postthoracotomy-pain-syndrome-in-lung-cancer-patients
#20
Victoria Khoronenko, Danil Baskakov, Marc Leone, Anna Malanova, Andrey Ryabov, Oleg Pikin, Maksim Golovashchenko
PURPOSE: Our study aimed to assess whether the type of regional anesthesia influenced the incidence of chronic postthoracotomy pain syndrome (CPTPS). METHODS: This was a prospective, randomized study that included 300 patients undergoing lung cancer resection using thoracotomy. They were randomized into three groups: paravertebral nerve block (PVB), thoracic epidural anesthesia (TEA), and intercostal nerve block (INB). General anesthesia was similar in the groups...
June 20, 2018: Annals of Thoracic and Cardiovascular Surgery
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