keyword
https://read.qxmd.com/read/38493143/low-intensity-pulsed-ultrasound-delays-the-progression-of-osteoarthritis-by-regulating-the-yap-ripk1-nf-%C3%AE%C2%BAb-axis-and-influencing-autophagy
#1
JOURNAL ARTICLE
Chunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo, Tao Xu
BACKGROUND: Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even disability. The risk factors for OA include genetics, gender, trauma, obesity, and age. Unfortunately, due to limited understanding of its pathological mechanism, there are currently no effective drugs or treatments to suspend the progression of osteoarthritis. In recent years, some studies found that low-intensity pulsed ultrasound (LIPUS) may have a positive effect on osteoarthritis...
March 16, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38493079/the-relationship-between-pregnancy-and-temporomandibular-disorder-tmd-through-diagnostic-criteria-for-temporomandibular-disorders-dc-tmd-axis-ii-evaluation-a-case-control-cross-sectional-study
#2
JOURNAL ARTICLE
Giuseppe Minervini, Maria Maddalena Marrapodi, Marco La Verde, Aida Meto, Yuliia Siurkel, Marco Cicciù, Diana Russo
INTRODUCTION: This study focuses on temporomandibular disorders (TMDs), which affect the temporomandibular joint and related muscles and have multiple causes. Recent studies have examined the connection between menstrual cycles, estrogen levels, and TMDs, but results are inconsistent, highlighting the need for more research. The aim is to explore the prevalence of TMDs in pregnant women and consider how hormonal changes during pregnancy might influence these disorders. METHODS: In this cross-sectional case-control study, we compared 32 pregnant women with 35 non-pregnant women...
March 16, 2024: BMC Oral Health
https://read.qxmd.com/read/38492991/online-learning-to-improve-nurses-knowledge-attitudes-and-self-efficacy-about-managing-postoperative-pain-in-older-adults
#3
JOURNAL ARTICLE
Phichpraorn Youngcharoen, Chayada Piyakhachornrot
BACKGROUND: Older adults undergoing total knee arthroplasty may develop chronic pain without effective postoperative pain management. Increasing nurses' knowledge, changing their attitudes, and developing their pain management self-efficacy could improve the effectiveness of pain management. AIM: To determine the effectiveness of an online learning program to help registered nurses to manage postoperative pain in older adults undergoing total knee arthroplasty. DESIGN: A quasi-experimental pre-test-post-test design with intervention and control groups...
March 15, 2024: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://read.qxmd.com/read/38492990/fatigue-and-depressive-mood-in-chronic-low-back-pain
#4
JOURNAL ARTICLE
Anitha Saravanan, Prempreet Bajaj, Herbert L Matthews, Dina Tell, Angela Starkweather, Linda Janusek
PURPOSE: Fatigue is prevalent, problematic, and co-occurs in chronic low back pain. When left untreated, fatigue can increase depressive mood, and intensify pain burden and disability in patients with chronic low back pain. The purpose of this study was to examine the relationship of fatigue to depressive mood, pain severity, and pain interference in patients with chronic low back pain. DESIGN AND METHODS: A cross-sectional design was used to enroll and evaluate adults (n = 67) with chronic low back pain (>6 months) during their visit to an outpatient pain clinic...
March 15, 2024: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://read.qxmd.com/read/38492895/olfactory-ensheathing-cells-as-candidate-cells-for-chronic-pain-treatment
#5
REVIEW
Mei-Chen Liu, Qing-Fa Guo, Wei-Wei Zhang, Hong-Liang Luo, Wen-Jun Zhang, Hai-Jun Hu
Chronic pain is often accompanied by tissue damage and pain hypersensitivity. It easily relapses and is challenging to cure, which seriously affects the patients' quality of life and is an urgent problem to be solved. Current treatment methods primarily rely on morphine drugs, which do not address the underlying nerve injury and may cause adverse reactions. Therefore, in recent years, scientists have shifted their focus from chronic pain treatment to cell transplantation. This review describes the classification and mechanism of chronic pain through the introduction of the characteristics of olfactory ensheathing cells (OECs), an in-depth discussion of special glial cells through the phagocytosis of nerve debris, receptor-ligand interactions, providing nutrition, and other inhibition of neuroinflammation, and ultimately supporting axon regeneration and mitigation of chronic pain...
March 14, 2024: Journal of Chemical Neuroanatomy
https://read.qxmd.com/read/38492711/age-race-ethnicity-and-sex-of-participants-in-clinical-trials-focused-on-chronic-pain
#6
JOURNAL ARTICLE
Taylor Boyd, Joseph Chibueze, Bethany D Pester, Rhea Saini, Nir Bar, Robert R Edwards, Meredith C B Adams, Julie K Silver, Samantha M Meints, Helen Burton-Murray
There are limited data on equitable inclusion in chronic pain trials. We aimed to (1) identify frequency of reporting age, race, ethnicity, and sex in clinical trials targeting chronic pain, and (2) compare sociodemographic representation to the United States (US) population. We examined US-based intervention trials for chronic pain registered on ClinicalTrials.gov initiated between 2007-2021. We (1) assessed the frequency of reporting each demographic variable, (2) compared representation with US population estimates, and (3) explored change in reporting over time...
March 14, 2024: Journal of Pain
https://read.qxmd.com/read/38492710/parent-anxiety-depression-protective-responses-and-parenting-stress-in-the-context-of-parent-and-child-chronic-pain-a-daily-diary-study-of-parent-variability
#7
JOURNAL ARTICLE
Jaimie K Beveridge, Andrew Walker, Serena L Orr, Anna C Wilson, Kathryn A Birnie, Melanie Noel
Parents with (versus without) chronic pain report poorer psychosocial functioning (e.g., worse mental health, parenting difficulties), which has been linked to poorer child outcomes (e.g., child pain). However, emerging research suggests that individuals vary in their functioning from day-to-day, particularly those with chronic pain. This study used daily diaries to compare parents with (versus without) chronic pain on variability in their anxiety, mood, protective responses, and parenting stress. We also examined parent chronic pain status as a moderator of the associations between parent variability and youth daily pain and interference...
March 14, 2024: Journal of Pain
https://read.qxmd.com/read/38492631/quantitative-sensory-testing-in-canine-musculoskeletal-pain-findings-from-a-systematic-review-meta-analysis-feasibility-assessment-and-limitations
#8
JOURNAL ARTICLE
B P Monteiro, C Otis, R Nitulescu, E Troncy
Quantitative sensory testing (QST) allows the study of pain mechanisms, patient phenotyping, and response to therapy. The goals of this study were to conduct a systematic review of the use of QST in dogs with musculoskeletal disease including osteoarthritis (OA), and to assess, by means of a meta-analysis, the ability of QST to differentiate affected dogs from healthy controls. The study protocol was registered; three bibliographic databases were screened. Studies involving QST in healthy dogs and those with musculoskeletal disease were included...
March 14, 2024: Veterinary Journal
https://read.qxmd.com/read/38491460/is-erenumab-an-efficient-alternative-for-the-prevention-of-episodic-and-chronic-migraine-in-spain-results-of-a-cost-effectiveness-analysis
#9
JOURNAL ARTICLE
Patricia Pozo-Rosich, José Luis Poveda, Carlos Crespo, María Martínez, José Manuel Rodríguez, Pablo Irimia
BACKGROUND: The reimbursement of erenumab in Spain and other European countries is currently restricted because of the cost of this novel therapy to patients with migraine who have experienced previous failures to traditional preventive treatments. However, this reimbursement policy should be preferably based on cost-effectiveness studies, among other criteria. This study performed a cost-effectiveness analysis of erenumab versus topiramate for the prophylactic treatment of episodic migraine (EM) and versus placebo for chronic migraine (CM)...
March 15, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38491439/daoyin-therapy-in-chronic-neck-pain-study-protocol-for-a-randomized-controlled-trial
#10
JOURNAL ARTICLE
Xiangxu Chen, Mingze Zhu, Wei Li, Daan Wang, Jing Liu
BACKGROUND: Daoyin therapy (DT), an ancient therapeutic approach with a history spanning thousands of years, has traditionally been employed to address musculoskeletal pain and psychosomatic disorders. However, the application of DT for chronic neck pain (CNP) has received limited attention in the existing literature, and systematic randomized clinical trials (RCTs) in this context remain scarce. This manuscript outlines an RCT protocol designed to investigate whether DT is more effective at alleviating CNP in adult individuals compared to other interventions...
March 15, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38491415/cgrp-monoclonal-antibodies-in-japan-insights-from-an-online-survey-of-physician-members-of-the-japanese-headache-society
#11
JOURNAL ARTICLE
Tsubasa Takizawa, Keiko Ihara, Narumi Watanabe, Ryo Takemura, Nobuyuki Takahashi, Naoki Miyazaki, Mamoru Shibata, Keisuke Suzuki, Noboru Imai, Norihiro Suzuki, Koichi Hirata, Takao Takeshima, Jin Nakahara
BACKGROUND: Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) have greatly changed migraine treatment options. In Japan, although CGRPmAb guidelines (≥ 4 monthly migraine days (MMDs) and ≥ 1 previous preventive failure) are well-acknowledged, the actual use of CGRPmAbs and the circumstances of the related headache care are unknown. METHODS: We conducted an online survey of Japanese Headache Society members, inquiring about the physicians' experience with CGRPmAbs and how they make decisions related to their use...
March 15, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38491303/the-effect-of-breathing-exercises-and-mindset-with-or-without-cold-exposure-on-mental-and-physical-health-in-persons-with-a-spinal-cord-injury-a-protocol-for-a-three-arm-randomised-controlled-trial
#12
JOURNAL ARTICLE
Sven Hoekstra, Frank Ettema, Max van der Bijll, Vera van der Sterren, Ellen van Binsbergen, Ludwine van Orsouw, Wendy Achterberg, Hein Daanen, Thomas Janssen, Sonja de Groot
STUDY DESIGN: A three-arm randomized controlled trial. OBJECTIVES: To investigate the effects of the Wim Hof Method (WHM), with (WHM-C) and without cold exposure (WHM-NC), on mental and physical health in persons with chronic spinal cord injury (SCI). SETTING: Rehabilitation centre (assessments and once-weekly intervention sessions) and home-based (daily intervention sessions). METHODS: Sixty adults with chronic SCI will be randomised (1:1:1) to one of three groups: participants in the intervention groups (i...
March 15, 2024: Spinal Cord
https://read.qxmd.com/read/38491245/plant-produced-therapeutic-crizanlizumab-monoclonal-antibody-binds-p-selectin-to-alleviate-vaso-occlusive-pain-crises-in-sickle-cell-disease
#13
REVIEW
Taewon Yang, Hyunjoo Hwang, Kibum Kim, Yerin Kim, Richard D Cummings, Yong Kyoo Shin, Taejin Lee, Kisung Ko
Sickle Cell Disease (SCD) is a severe genetic disorder causing vascular occlusion and pain by upregulating the adhesion molecule P-selectin on endothelial cells and platelets. It primarily affects infants and children, causing chronic pain, circulatory problems, organ damage, and complications. Thus, effective treatment and management are crucial to reduce SCD-related risks. Anti-P-selectin antibody Crizanlizumab (Crimab) has been used to treat SCD. In this study, the heavy and light chain (HC and LC) genes of anti-P-Selectin antibody Crimab were cloned into a plant expression binary vector...
March 15, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38490830/surgical-outcomes-of-ipsilateral-inguinal-hernia-after-kidney-transplantation
#14
JOURNAL ARTICLE
Hirosuke Ishikawa, Takashi Kobayashi, Kohei Miura, Masayuki Tasaki, Kazuhide Saito, Kazuyasu Takizawa, Jun Sakata, Toshifumi Wakai
OBJECTIVES: We aimed to clarify the clinical features and outcomes of ipsilateral inguinal hernias after kidney transplantation. PATIENTS AND METHODS: Eleven patients diagnosed with inguinal hernia on the ipsilateral side after kidney transplantation between 2011 and 2022 were analyzed. Clinical data were retrospectively reviewed from the medical records. RESULT: Eleven patients were included in the analysis (median age, 68 [range, 28-75] years, male, n = 11)...
March 14, 2024: Transplantation Proceedings
https://read.qxmd.com/read/38490776/vibratory-impact-of-3-different-ambulance-suspension-systems-on-the-simulated-neonate-and-health-care-provider-during-normal-driving-conditions
#15
JOURNAL ARTICLE
Trevor Pier, Justin S Misuraca, Maria J Mandt
OBJECTIVE: Patients and health care providers experience varying degrees of vibration during interfacility ground transport. The impact of vibration on term and preterm neonates may result in physiologic instability and increased risk of intracranial hemorrhage, whereas the impact on health care providers has been shown to include an increase in perceived and physiologic stress levels and may contribute to chronic back and neck pain. This study aimed to evaluate 3 common ambulance suspension systems and the corresponding vibratory impact produced during typical interfacility driving conditions on adult caregiver and neonatal patient mannequins...
2024: Air Medical Journal
https://read.qxmd.com/read/38490687/neurophysiological-outcomes-that-sustained-clinically-significant-improvements-over-3-years-of-physiologic-ecap-controlled-closed-loop-spinal-cord-stimulation-for-the-treatment-of-chronic-pain
#16
JOURNAL ARTICLE
Nagy A Mekhail, Robert M Levy, Timothy R Deer, Leonardo Kapural, Sean Li, Kasra Amirdelfan, Corey W Hunter, Steven M Rosen, Shrif J Costandi, Steven M Falowski, Abram H Burgher, Jason E Pope, Christopher A Gilmore, Farooq A Qureshi, Peter S Staats, James Scowcroft, Tory McJunkin, Christopher K Kim, Michael I Yang, Thomas Stauss, Richard Rauck, Rui V Duarte, Nicole Soliday, Angela Leitner, Erin Hanson, Zhonghua Ouyang, Dave Mugan, Lawrence Poree
INTRODUCTION: A novel, spinal cord stimulation (SCS) system with a physiologic closed-loop (CL) feedback mechanism controlled by evoked compound action potentials (ECAPs) enables the optimization of physiologic neural dose and the accuracy of the stimulation, not possible with any other commercially available SCS systems. The report of objective spinal cord measurements is essential to increase the transparency and reproducibility of SCS therapy. Here, we report a cohort of the EVOKE double-blind randomized controlled trial treated with CL-SCS for 36 months to evaluate the ECAP dose and accuracy that sustained the durability of clinical improvements...
March 15, 2024: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/38490193/promotion-of-physical-activity-by-qu%C3%A3-bec-primary-care-physicians-what-has-changed-in-the-last-decade
#17
JOURNAL ARTICLE
Suzanne Laberge, Véronique Gosselin, Kim Lestage, Miguel Chagnon, Claude Guimond
OBJECTIVE: This study aimed to assess the changes in the frequency of physical activity (PA) counseling and in the predictors of primary care PA promotion in Québec primary care physicians (PCPs) between 2010 and 2020. METHODS: In 2010, we conducted a survey among Québec PCPs. Questions included: frequency of promoting PA to patients, perceived barriers, needs to improve PA promotion practice, frequency of PCPs' PA practice, and sociodemographic information...
March 15, 2024: Journal of Physical Activity & Health
https://read.qxmd.com/read/38490158/painful-diabetic-neuropathy-the-role-of-ion-channels
#18
REVIEW
Qi Wang, Yifei Ye, Linghui Yang, Lifan Xiao, Jin Liu, Wensheng Zhang, Guizhi Du
Painful diabetic neuropathy (PDN) is a common chronic complication of diabetes that causes neuropathic pain and negatively affects the quality of life. The management of PDN is far from satisfactory. At present, interventions are primarily focused on symptomatic treatment. Ion channel disorders are a major cause of PDN, and a complete understanding of their roles and mechanisms may provide better options for the clinical treatment of PDN. Therefore, this review summarizes the important role of ion channels in PDN and the current drug development targeting these ion channels...
March 14, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38490051/prevalence-of-chronic-pain-after-severe-lower-limb-injury-slli-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Shareef Mahdi, Rebecca Stoner, James Wyatt, Henry De'Ath, Zane Perkins
BACKGROUND: Globally, severe lower limb injuries (SLLIs) are the predominant cause of long-term injury related disability and poor functional outcomes. Chronic pain is a major source of this morbidity, but the magnitude of the contribution is not clearly understood. The aim of this systematic review and meta-analysis was to determine the prevalence of chronic pain following SLLIs in civilian and military patients. METHOD: This systematic review was prospectively registered with The International Prospective Register of Systematic Reviews (PROSPERO) with study ID CRD42022313615...
March 12, 2024: Injury
https://read.qxmd.com/read/38489798/visualizing-global-chronic-pain
#20
JOURNAL ARTICLE
Jacob Michael Lurie, Amal Javaid
No abstract text is available yet for this article.
April 1, 2024: Anesthesia and Analgesia
keyword
keyword
330
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.