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Chiara Setti, Giulia Suarato, Giovanni Perotto, Athanassia Athanassiou, Ilker S Bayer
Emulsions are known to be effective carriers of hydrophobic drugs, and particularly injectable emulsions have been successfully implemented for in vivo controlled drug release. Recently, high internal phase emulsions have also been used to produce porous polymeric templates for pharmaceutical applications. However, emulsions containing dissolved biopolymers both in the oil and water phases are very scarce. In this study, we demonstrate such an emulsion, in which the oil phase contains a hydrophobic biodegradable polymer, MaterBi® , and the water phase is aqueous sodium alginate dispersion...
June 18, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Lihua Qi, Weihong Fan, Xian Xia, Lu Yao, Lirui Liu, Haiyan Zhao, Xiangyong Kong, Jie Liu
BACKGROUND: Candida parapsilosis is a common agew2nt of fungemia, but few outbreaks of Candida parapsilosis infection have been reported in China. AIM: This study aimed to elaborate an outbreak of nosocomial Candida parapsilosis sensu stricto fungemia in a neonatal intensive care unit (NICU) of a comprehensive hospital in China from July to October 2017. METHODS: Epidemics and characteristics of fungemia cases were investigated. Surveillance samples were collected...
June 18, 2018: Journal of Hospital Infection
Adem Emre Ilhan, Yusuf Muhammed Durna, Ahmet Mahmut Tekin, Fahrettin Yilmaz, Yetkin Zeki Yilmaz
AIM: To examine the effect of the piezoelectric application used increasingly for osteotomy and correction of nasal dorsum in septorhinoplasty surgeries on early auditory functions. METHODS: Our study was conducted after the decision of 10840098-604.01.01-E.9057 taken from Istanbul Medipol University Clinical Research Local Ethics Committee. This study was designed to be prospective, randomized and controlled. Twenty patients between 18 and 50 years of age that piezoelectric technique was used in the study group and 10 patients in the same age range who underwent nasal surgery (endoscopic sinus surgery, septoplasty, lower concha radiofrequency and nasal valve surgery) for any reason in the control group were included in the study...
June 20, 2018: Journal of Craniofacial Surgery
Pilib Ó Broin, Michael V Beckert, Tomohisa Takahashi, Takeshi Izumi, Kenny Ye, Gina Kang, Patricia Pouso, Mackenzie Topolski, Jose L Pena, Noboru Hiroi
Neonatal vocalization is structurally altered in mouse models of autism spectrum disorder (ASD). Our published data showed that pup vocalization, under conditions of maternal separation, contains sequences whose alterations in a genetic mouse model of ASD impair social communication between pups and mothers. We describe details of a method which reveals the statistical structure of call sequences that are functionally critical for optimal maternal care. Entropy analysis determines the degree of non-random call sequencing...
June 2018: Current Protocols in Mouse Biology
Michelle Samuel, Sara M Thomasy, Allison S Calderon, Philip H Kass, Keith Collins, Christopher J Murphy
OBJECTIVE: To determine the effect of 5% sodium chloride ophthalmic ointment (5% NaCl) on thickness and morphology of the normal canine cornea using ultrasonic pachymetry (USP), in vivo confocal microscopy (IVCM), and Fourier-domain optical coherence tomography (FD-OCT). METHODS: Five healthy laboratory Beagles received ophthalmic examinations including USP, IVCM, and FD-OCT prior to and at fixed intervals following treatment. The right and left eyes were treated with 5% NaCl and artificial tears ophthalmic ointment (AT), respectively, every 2 hours for 4 treatments/d (days 2-9), and then hourly for 7 treatments/d (day 10)...
June 21, 2018: Veterinary Ophthalmology
Anping Yan, Yunlan Guo, Chao Liu, Zhao Deng, Yi Guo, Xiujian Zhao
Topotactic anion exchange has been developed to tune the composition and band gap energies of cesium lead halide (CsPbX3 ) perovskite nanocrystals (NCs). However, current anion exchange methods either require harsh conditions or take a long time to realize substantial substitution. Here, we present a method to modulate the composition of colloidal CsPbBr3 NCs through ultrasonication-assisted anion exchange with CsX (X = Cl, I) solution. Efficient anion exchange of CsPbBr3 NCs with Cl- or I- is realized with substitution ratio up to 93% and preservation of the pristine shape and structure of CsPbBr3 NCs...
June 20, 2018: Nanoscale Research Letters
Wenrong Si, Chenzhao Fu, Delin Li, Haoyong Li, Peng Yuan, Yiting Yu
Extrinsic Fabry⁻Perot (FP) interferometric sensors are being intensively applied for partial discharge (PD) detection and localization. Previous research work has mainly focused on novel structures and materials to improve the sensitivity and linear response of these sensors. However, the directional response behavior of an FP ultrasonic sensor is also of particular importance in localizing the PD source, which is rarely considered. Here, the directional sensitivity of a microelectromechanical system (MEMS)-based FP ultrasonic sensor with a 5-μm-thick micromechanical vibrating diaphragm is experimentally investigated...
June 20, 2018: Sensors
Lili Ling, Yawei Feng, Sa Yan, Donglai Pan, Hao Ge, Hao Li, Hexing Li, Zhenfeng Bian
The introduction of piezoelectric field has been proven a promising method to enhance photocatalytic activity by preventing photoelectron-hole recombination. However, the formation of piezoelectric field requires additional mechanical force or high-frequency ultrasonic baths, which limits its potential application in industrial scale. Therefore, it is of great practical significance to design the catalyst which can harvest the discrete energy such as the fluid mechanical energy to form the electric field. Herein, PZT/TiO2 catalyst with a core-shell configuration was prepared by a simple coating method...
June 21, 2018: Environmental Science & Technology
L Huang, T Yang, W Li, X T Wang, C M Xiong, X H Ni, Q Gu, J G He
Objective: To analyze the clinical features of post-splenectomy pulmonary hypertension and effects of its target therapy, and improve the diagnosis and treatment of the disease. Methods: Clinical data of 18 patients with post-splenectomy pulmonary hypertension admitted to Fuwai Hospital from October 2006 to March 2017 were systematically reviewed and analyzed. Results: Among the 18 patients with a mean age of (41±11) years old, 11 were women and 7 were men. The interval between splenectomy and the diagnosis of pulmonary hypertension was (11±6) years...
June 12, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
M G Yin, X T Wang, D W Liu, Y G Chao, X D Guan, Y Kang, J Yan, X C Ma, Y Q Tang, Z J Hu, K J Yu, D C Chen, Y H Ai, L N Zhang, H M Zhang, J Wu, L X Liu, R Zhu, W He, Q Zhang, X Ding, L Li, Y Li, H T Liu, Q B Zeng, X Si, H Chen, J W Zhang, Q H Xu, W J Chen, X K Chen, D Z Huang, S H Cai, X L Shang, J Guan, J Du, L Zhao, M J Wang, S Cui, X M Wang, R Zhou, X Y Zeng, Y P Wang, L W Lyu, W H Zhu, Y Zhu, J Duan, J Yang, H Yang
Critical ultrasonography(CUS) is different from the traditional diagnostic ultrasound, the examiner and interpreter of the image are critical care medicine physicians. The core content of CUS is to evaluate the pathophysiological changes of organs and systems and etiology changes. With the idea of critical care medicine as the soul, it can integrate the above information and clinical information, bedside real-time diagnosis and titration treatment, and evaluate the therapeutic effect so as to improve the outcome...
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Beatriz Picazo-Angelin, Juan Ignacio Zabala-Argüelles, Robert H Anderson, Damian Sánchez-Quintana
The rapid changes that have taken place in recent years in relation to techniques used to image the fetal heart have emphasized the need to have a detailed knowledge ofnormal cardiac anatomy. Without such knowledge, it is difficult, if not impossible, to recognize the multiple facets of congenital cardiac disease. From the inception of fetal echocardiographic screening, the importance of basic knowledge of cardiac anatomy has been well recognized. The current machines used for imaging, however, now make it possible potentially to recognize features not appreciated at the start of the specialty...
May 2018: Annals of Pediatric Cardiology
Ernst Niederleithinger, Xin Wang, Martin Herbrand, Matthias Müller
Ultrasonic transmission measurements have been used for decades to monitor concrete elements, mostly on a laboratory scale. Recently, coda wave interferometry (CWI), a technique adapted from seismology, was introduced to civil engineering experiments. It can be used to reveal subtle changes in concrete laboratory samples and even large structural elements without having a transducer directly at the place where the change is taking place. Here, several load tests until failure on large posttensioned concrete beams have been monitored using networks of embedded transducers...
June 19, 2018: Sensors
Yuan Zhang, Wei-E Zhou, Jia-Qing Yan, Min Liu, Yu Zhou, Xin Shen, Ying-Lin Ma, Xue-Song Feng, Jun Yang, Guo-Hui Li
Vitamins are a class of essential nutrients in the body; thus, they play important roles in human health. The chemicals are involved in many physiological functions and both their lack and excess can put health at risk. Therefore, the establishment of methods for monitoring vitamin concentrations in different matrices is necessary. In this review, an updated overview of the main pretreatments and determination methods that have been used since 2010 is given. Ultrasonic assisted extraction, liquid⁻liquid extraction, solid phase extraction and dispersive liquid⁻liquid microextraction are the most common pretreatment methods, while the determination methods involve chromatography methods, electrophoretic methods, microbiological assays, immunoassays, biosensors and several other methods...
June 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Gil Chernin, Iris Szwarcfiter, Dierk Scheinert, Erwin Blessing, Nicolas Diehm, Jo Dens, Antony Walton, Stefan Verheye, Sharad Shetty, Michael Jonas
PURPOSE: To report results of renal denervation (RDN) with the first catheter-based, non-balloon occlusion ultrasonic system in patients with resistant hypertension. MATERIALS AND METHODS: In a multicenter, single-arm trial, 39 patients with resistant hypertension (defined as uncontrolled hypertension while taking ≥ 3 antihypertensive medications) were treated. The cohort consisted of 4 groups: severe resistant hypertension (office systolic blood pressure [OSBP] ≥ 160 mm Hg) treated with a unidirectional catheter (group 1; n = 14); severe resistant hypertension treated with a multidirectional catheter (group 2; n = 18); moderate resistant hypertension (OSBP 140-159 mm Hg) treated with a multidirectional catheter (group 3; n = 5); and recurrent severe resistant hypertension, after an initial response to RF RDN (group 4; n = 2)...
June 16, 2018: Journal of Vascular and Interventional Radiology: JVIR
Milan Gautam, Sae Kwang Ku, Jong Oh Kim, Jeong Hoon Byeon
Chemophototherapy is an advanced cancer therapeutic that uses photothermal nanocarriers (NCs) responsive to near-infrared (NIR) light. For the past decade, chemophototherapy has been investigated intensively for clinical translation, and continuous-flow production of biofunctional compounds (NCs, drugs, probes, nanocomposites) has received increasing attention for future therapeutics. However, in situ supply of a stimuli-responsive inorganic core and subsequent tight drug loading on the core are challenging tasks in the practical use of on-demand nanomedicines...
June 19, 2018: Nanoscale
Breeanne M Soteros, Qifei Cong, Christian R Palmer, Gek-Ming Sia
The FoxP2 transcription factor and its target genes have been implicated in developmental brain diseases with a prominent language component, such as developmental verbal dyspraxia and specific language impairment. How FoxP2 affects neural circuitry development remains poorly understood. The sushi domain protein SRPX2 is a target of FoxP2, and mutations in SRPX2 are associated with language defects in humans. We have previously shown that SRPX2 is a synaptogenic protein that increases excitatory synapse density...
2018: PloS One
Luhui Yang, Allison Yu, Rolf Mueller
The ultrasonic emission in the biosonar systems of bats such as the Old World leaf-nosed bats (family Hipposideridae) and the related horseshoe bats (family Rhinolophidae) is characterized by a unique dynamics where baffle shapes ("noseleaves") deform while diffracting the outgoing wave packets. As of now, nothing comparable to this dynamics has been used in any related engineering application (e.g., sonar or radar). Prior work with simple concave baffle shapes has demonstrated an impact of the dynamics on the emission characteristics, but it has remained unclear if this was simply due to the change in aperture size or also influenced by geometrical shape detail...
June 19, 2018: Bioinspiration & Biomimetics
Jia Ye, Siyang Tang, Long Meng, Xia Li, Xiaoxu Wen, Sihan Chen, Lili Niu, Xiangyao Li, Weibao Qiu, Hailan Hu, Mizu Jiang, Shiqiang Shang, Qiang Shu, Hairong Zheng, Shumin Duan, Yuezhou Li
Externally controlling the excitation of a neuronal subset through ion channels activation can modulate the firing pattern of an entire neural circuit in vivo. As nanovalves in the cell membrane, ion channels can be opened by light (optogenetics) or ultrasonic (sonogenetics) means. A thoroughly analyzed force sensor is the Escherichia coli mechano sensitive channel of large conductance (MscL). Here we expressed MscL in rat hippocampal neurons in a primary culture and showed that it could be activated by low-pressure ultrasound pulses...
June 19, 2018: Nano Letters
Hongyan Ma, Qi Huang, Wenshan Qu, Linyuan Li, Min Wang, Shao Li, Fujiang Chu
ETHNOPHARMACOLOGICAL RELEVANCE: The dried roots of Sophora flavescens Ait. (Leguminosae) is traditionally used as antipyretic medicine to reduce inflammation. It is well known that alkaloids and flavonoids are the main constituents of S. flavescens. However, the clinical researches and applications of S. flavescens is mainly based on its water-extracted alkaloids, its flavonoids may still remain in residues and have been underused. With development and manufacturing of S. flavescens in recent years, more herb residues are being produced...
June 15, 2018: Journal of Ethnopharmacology
Chanapai Chaiyakulsil, Marut Chantra, Poomiporn Katanyuwong, Anant Khositseth, Nattachai Anantasit
INTRODUCTION: Hemodynamic parameters measurements were widely conducted using pulmonary artery catheter (PAC) with thermodilution as a reference standard. Due to its technical difficulties in children, transthoracic echocardiography (TTE) has been widely employed instead. Nonetheless, TTE requires expertise and is time-consuming. Noninvasive cardiac output monitoring such as ultrasonic cardiac output monitor (USCOM) and electrical velocimetry (EV) can be performed rapidly with less expertise requirement...
2018: PloS One
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