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https://www.readbyqxmd.com/read/29728595/pkc-dependent-p14arf-phosphorylation-on-threonine-8-drives-cell-proliferation
#1
Rosa Fontana, Daniela Guidone, Felicia Sangermano, Viola Calabrò, Alessandra Pollice, Girolama La Mantia, Maria Vivo
ARF role as tumor suppressor has been challenged in the last years by several findings of different groups ultimately showing that its functions can be strictly context dependent. We previously showed that ARF loss in HeLa cells induces spreading defects, evident as rounded morphology of depleted cells, accompanied by a decrease of phosphorylated Focal Adhesion Kinase (FAK) protein levels and anoikis. These data, together with previous finding that a PKC dependent signalling pathway can lead to ARF stabilization, led us to the hypothesis that ARF functions in cell proliferation might be regulated by phosphorylation...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29705012/an-alternative-thumb-reconstruction-by-double-microsurgical-transfer-from-the-great-and-second-toe-for-a-carpometacarpal-amputation
#2
REVIEW
Ignacio Roger de Oña, Andrea Garcia Villanueva, Alexis Studer de Oya
Thumb amputation at the carpometacarpal level is very incapacitating. Pollicization may be considered. We describe an alternate technique for thumb reconstruction at the level of the metacarpal base using a trimmed great toe along with a vascularized second metatarsophalangeal joint, including the second metatarsal, all supplied on a single vascular pedicle. Two patients who had a combined soft tissue defect and amputation of the thumb close to the carpometacarpal joint were reconstructed with this method. A transposition of the second toe was performed on top of the remaining proximal phalanx of the great toe to decrease donor site morbidity...
April 25, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29623751/scapular-muscle-activity-during-static-yoga-postures
#3
Jaclyn N Chopp-Hurley, Courtney Prophet, Brynn Thistle, Jessica Pollice, Monica R Maly
Study Design Controlled laboratory study; cross-sectional. Background Despite the growing popularity of yoga, little is known about the muscle activity of the scapular stabilizers during isometric yoga postures and their potential utility in shoulder rehabilitation. Objectives To examine scapular stabilizer muscle activation during various yoga postures. Methods Twenty women with yoga experience and no shoulder pain or injury participated. Electromyography was used to record upper, middle and lower trapezius as well as serratus ante-rior muscle activity during 15 yoga postures...
April 6, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29605519/a-new-direct-measure-of-thumb-use-in-children-after-index-pollicization-for-congenital-thumb-hypoplasia
#4
Kathleen M Kollitz, Wendy A Tomhave, Ann E Van Heest, Steven L Moran
PURPOSE: After index pollicization for congenital thumb hypoplasia, time-based hand dexterity tests do not indicate whether the new thumb is being used by a child. The Thumb Grasp and Pinch assessment (T-GAP) is a new outcome measure that classifies grasp and pinch styles to quantify use of the new thumb. The goal of this study was to establish concurrent validity and construct validity in the T-GAP. METHODS: Data from children treated with index finger pollicization for congenital thumb hypoplasia were retrospectively reviewed...
March 28, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29558847/variations-in-the-origins-and-absence-of-the-common-digital-arteries-of-the-hand-a-cadaveric-study
#5
Ahmed M Hashem, Rebecca W Knackstedt, Steven Bernard, Mark Hendrickson, Jennifer M McBride, Risal Djohan
We studied anomalies of the common digital arteries by dissecting 33 fresh cadaver hands under magnification. In the majority of the dissected hands (25 hands), common digital arteries took off from the superficial palmar arch and ran superficial and parallel to the flexor tendons. Variations were found in eight out of 33 hands. In four hands the common digital artery to the second web space was replaced by an atypical vessel, originating from the deep palmar arch, that crossed posterior to the index flexor tendons proximal to the A1 pulley...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29481400/change-in-hand-function-and-dexterity-with-age-after-index-pollicization-for-congenital-thumb-hypoplasia
#6
Kathleen M Kollitz, Wendy Tomhave, Ann E Van Heest, Steven L Moran
BACKGROUND: Little is known about how performance on strength, range of motion, and dexterity measures changes as children with index finger pollicization mature. The authors reviewed performance in range of motion, strength, and dexterity over a 7-year period and report outcomes over time. METHODS: Data from children treated with index finger pollicization for congenital thumb hypoplasia from 2007 to 2014 were reviewed retrospectively. Children were followed for an average of 3...
March 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29246538/sumoylation-and-ubiquitylation-crosstalk-in-the-control-of-%C3%AE-np63%C3%AE-protein-stability
#7
Michela Ranieri, Maria Vivo, Marco De Simone, Luisa Guerrini, Alessandra Pollice, Girolama La Mantia, Viola Calabrò
ΔNp63α is finely and strictly regulated during embryogenesis and differentiation. ΔNp63α is the only p63 isoform degraded by the proteasome after Ubiquitin and SUMO (Small Ubiquitin-like MOdifier) conjugation. Here, we show that p63 ubiquitylation per se is not the signal triggering p63 proteasomal degradation. Taking advantage of natural ΔNp63α mutants isolated by patients with Split Hand and Foot Malformation IV syndrome, we found that SUMO and Ub modifications are not redundant and both are required to guarantee efficient ΔNp63α degradation...
March 1, 2018: Gene
https://www.readbyqxmd.com/read/28964869/anti-proliferative-and-pro-apoptotic-effects-of-uncaria-tomentosa-aqueous-extract-in-squamous-carcinoma-cells
#8
Francesca Ciani, Simona Tafuri, Annaelena Troiano, Alessio Cimmino, Bianca Saveria Fioretto, Andrea Maria Guarino, Alessandra Pollice, Maria Vivo, Antonio Evidente, Domenico Carotenuto, Viola Calabrò
Uncaria tomentosa (Willd.) DC. (Rubiacee), also known as uña de gato, is a plant that grows wild in the upper Amazon region of Peru and has been widely used in folk medicine to treat several health conditions including cancer. We have produced an aqueous extract from Uncaria tomentosa (UT-ex) and analyzed its effects on squamous carcinoma cells and immortalized HaCaT keratinocytes. Squamous cell carcinoma (SCC) is an uncontrolled growth of abnormal cells arising in the skin's squamous layer of epidermis. When detected at an early stage, SCCs are almost curable, however, if left untreated, they can penetrate the underlying tissue and become disfiguring...
September 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28917547/growth-of-the-new-thumb-metacarpal-after-pollicization-for-thumb-hypoplasia
#9
Michael A Tonkin, Nathan D Trist, Dirk J van der Spuy, Albert Yoon, Harvinder P Singh, Richard D Lawson
PURPOSE: To investigate the radiographic length and width of the new thumb metacarpal in relation to the middle finger proximal phalanx; to assess the incidence of premature physeal closure of the new metacarpal; and to consider whether there is a relationship between growth characteristics and the presence of union or nonunion of the new trapezium to the retained index finger metacarpal base. METHODS: Forty pollicizations were assessed with preoperative or immediate postoperative radiographs and follow-up radiographs to establish the growth characteristics of the new thumb metacarpal...
January 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28914662/a-concealed-case-of-takotsubo-syndrome-as-consequence-of-ab-ingestis-episode-in-a-revascularized-patient
#10
Andrea I Guaricci, Rita L Musci, Paolo Pollice, Vito Marangelli, Martino Pepe, Filippo Masi, Frida Nacci, Domenico Zanna, Stefano Favale
No abstract text is available yet for this article.
December 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28783363/quaternary-ammonium-salts-as-alkylating-reagents-in-c-h-activation-chemistry
#11
Manuel Spettel, Robert Pollice, Michael Schnürch
A rhodium(I)-catalyzed alkylation reaction of benzylic amines via C(sp(3))-H activation using quaternary ammonium salts as alkyl source is described. The reaction proceeds via in situ formation of an olefin via Hofmann elimination, which is the actual alkylating reagent. This represents an operationally simple method for substituting gaseous and liquid olefins with solid quaternary ammonium salts as alkylating reagents, which is transferable to other C-H activation protocols as well.
August 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28606622/reconstruction-of-combined-thumb-amputation-at-the-metacarpal-base-level-and-index-amputation-at-the-metacarpal-level-with-pollicization-and-bilateral-double-toe-composite-transfer
#12
Zhenglin Chi, Da Jiang Song, Lin Tian, Fu Hua Hu, Xiao Fang Shen, Harvey Chim
BACKGROUND: This study aimed to describe the technique and report our experience with the reconstruction of combined proximal thumb amputations at the metacarpal base level and index finger amputation at the metacarpal level with pollicization and bilateral double toe composite transfer. METHODS: The technique consists of pollicization of the remnant index ray. Then a contralateral composite medial great toe pulp and vascularized second toe proximal interphalangeal joint flap are harvested to reconstruct the metacarpophalangeal joint of the thumb...
August 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28509696/on-top-index-pollicization-after-a-partial-amputation-of-a-syndactylized-hypoplastic-thumb-in-a-patient-with-townes-brocks-syndrome
#13
Mia Lorencin, Kresimir Bulic
Townes-Brocks syndrome is a rare autosomal dominant syndrome characterized by multiple malformations, including thumb anomalies. Thumb hypoplasia poses a specific problem, where a deficient thumb creates a significant handicap in hand function. The treatment goal is enabling pinch and grip activity, and the preferred procedure for a severely hypoplastic thumb is index finger pollicization. We present a case of on-top index pollicization in a 10-year-old, after a partial amputation of a previously syndactylized hypoplastic thumb, with a well-formed first carpometacarpal joint...
September 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28450097/near-infrared-vein-visualization-in-index-finger-pollicization
#14
REVIEW
Brooks W Ficke, Erin F Ransom, Jean E Oakes
Near-infrared vein visualization devices allow for noninvasive identification of superficial veins. During index finger pollicization, preservation of the dorsal veins is important for protecting blood outflow from the digit. Near-infrared vein visualization devices can be used to identify the location of the dorsal veins prior to skin incision, allowing increased confidence during dissection. We describe the use of this device to identify veins during index finger pollicization.
April 25, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28436949/p14arf-interacts-with-the-focal-adhesion-kinase-and-protects-cells-from-anoikis
#15
M Vivo, R Fontana, M Ranieri, G Capasso, T Angrisano, A Pollice, V Calabrò, G La Mantia
The ARF protein functions as an important sensor of hyper-proliferative stimuli restricting cell proliferation through both p53-dependent and -independent pathways. Although to date the majority of studies on ARF have focused on its anti-proliferative role, few studies have addressed whether ARF may also have pro-survival functions. Here we show for the first time that during the process of adhesion and spreading ARF re-localizes to sites of active actin polymerization and to focal adhesion points where it interacts with the phosphorylated focal adhesion kinase...
August 24, 2017: Oncogene
https://www.readbyqxmd.com/read/28362302/identification-of-the-faecal-indicator-escherichia-coli-in-wastewater-through-the-%C3%AE-d-glucuronidase-activity-comparison-between-two-enumeration-methods-membrane-filtration-with-tbx-agar-and-colilert-%C3%A2-18
#16
COMPARATIVE STUDY
P Vergine, C Salerno, E Barca, G Berardi, A Pollice
Escherichia coli (E. coli) is one of the most commonly adopted indicators for the determination of the microbiological quality in water and treated wastewater. Two main types of methods are used for the enumeration of this faecal indicator: membrane filtration (MF) and enzyme substrate tests. For both types, several substrates based on the β-D-glucuronidase activity have been commercialized. The specificity of this enzyme for E. coli bacteria has generated considerable use of methods that identify the β-D-glucuronidase activity as a definite indication of the presence of E...
April 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/27843661/metastatic-prostate-cancer-of-hand
#17
Akihito Nagano, Takatoshi Ohno, Koji Oshima, Daichi Ishimaru, Yutaka Nishimoto, Yoshiyuki Ohno, Akihiro Hirakawa, Tatsuhiko Miyazaki, Haruhiko Akiyama
Soft tissue metastases of prostate cancer to other sites are extremely rare, and, to our best knowledge, there have been no reports of metastasis to soft tissue of the hand. A 63-year-old man was diagnosed with prostatic cancer. During treatment, bone and soft tissue metastases to the right hand, appearing in the first web space, were observed. The tumor was resected, along with both the first and second metacarpal bones. The thumb was reconstructed by pollicization of the remaining index finger, enabling the patient to use the pollicized thumb for activities of daily living...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27816351/influence-of-air-scouring-on-the-performance-of-a-self-forming-dynamic-membrane-bioreactor-sfd-mbr-for-municipal-wastewater-treatment
#18
Carlo Salerno, Pompilio Vergine, Giovanni Berardi, Alfieri Pollice
The Membrane BioReactor (MBR) is a well-established filtration-based technology for wastewater treatment. Despite the high quality of the effluent produced, one of the main drawbacks of the MBR is membrane fouling. In this context, a possible evolution towards systems having potentially lower installation and operating costs is the Self Forming Dynamic Membrane BioReactor (SFD MBR). Key of this technology is the self-formation of a biological filtering layer on a support of inert material. In this work, a lab-scale aerobic SFD MBR equipped with a nylon mesh was operated at approximately 95Lm(-2)h(-1)...
January 2017: Bioresource Technology
https://www.readbyqxmd.com/read/27712753/secondary-thumb-reconstruction-in-a-mutilated-hand
#19
REVIEW
David Graham, Praveen Bhardwaj, S Raja Sabapathy
The thumb plays an integral role in hand function. Traumatic amputation results in significant morbidity. With loss of the thumb, up to a 40% reduction in hand function may result. Thumb replantation must be attempted when possible. The goals of thumb reconstruction are to replicate normal function as closely as possible, minimize donor site morbidity, and expedite recovery. In the setting of a mutilated hand, the status of the remaining digits must be carefully assessed. Toe transfers, osteoplastic thumb reconstruction, and pollicization are commonly used...
November 2016: Hand Clinics
https://www.readbyqxmd.com/read/27580437/-pollicization-of-the-index-finger-in-patients-with-congenital-thumb-hypoplasia
#20
U Moser, G Singer, B Schmidt, S Spendel
Congenital thumb hypoplasia is a radial deficiency occurring in the form of sole dysplasia or in combination with additional aberrations. Thumb hypoplasia can be categorised into 5 grades ranging from mild deformity to complete absence of the thumb. Thumb hypoplasia leads to a disturbance of grip function depending on its severity. The choice of treatment is based on the degree of thumb hypoplasia. For hypoplasia greater than grade 3B, restoration of the thumb using pollicization of the index finger is the treatment of choice...
August 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
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