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Akihito Nagano, Takatoshi Ohno, Koji Oshima, Daichi Ishimaru, Yutaka Nishimoto, Yoshiyuki Ohno, Akihiro Hirakawa, Tatsuhiko Miyazaki, Haruhiko Akiyama
Soft tissue metastases of prostate cancer to other sites are extremely rare, and, to our best knowledge, there have been no reports of metastasis to soft tissue of the hand. A 63-year-old man was diagnosed with prostatic cancer. During treatment, bone and soft tissue metastases to the right hand, appearing in the first web space, were observed. The tumor was resected, along with both the first and second metacarpal bones. The thumb was reconstructed by pollicization of the remaining index finger, enabling the patient to use the pollicized thumb for activities of daily living...
2016: Case Reports in Orthopedics
Carlo Salerno, Pompilio Vergine, Giovanni Berardi, Alfieri Pollice
The Membrane BioReactor (MBR) is a well-established filtration-based technology for wastewater treatment. Despite the high quality of the effluent produced, one of the main drawbacks of the MBR is membrane fouling. In this context, a possible evolution towards systems having potentially lower installation and operating costs is the Self Forming Dynamic Membrane BioReactor (SFD MBR). Key of this technology is the self-formation of a biological filtering layer on a support of inert material. In this work, a lab-scale aerobic SFD MBR equipped with a nylon mesh was operated at approximately 95Lm(-2)h(-1)...
January 2017: Bioresource Technology
David Graham, Praveen Bhardwaj, S Raja Sabapathy
The thumb plays an integral role in hand function. Traumatic amputation results in significant morbidity. With loss of the thumb, up to a 40% reduction in hand function may result. Thumb replantation must be attempted when possible. The goals of thumb reconstruction are to replicate normal function as closely as possible, minimize donor site morbidity, and expedite recovery. In the setting of a mutilated hand, the status of the remaining digits must be carefully assessed. Toe transfers, osteoplastic thumb reconstruction, and pollicization are commonly used...
November 2016: Hand Clinics
U Moser, G Singer, B Schmidt, S Spendel
Congenital thumb hypoplasia is a radial deficiency occurring in the form of sole dysplasia or in combination with additional aberrations. Thumb hypoplasia can be categorised into 5 grades ranging from mild deformity to complete absence of the thumb. Thumb hypoplasia leads to a disturbance of grip function depending on its severity. The choice of treatment is based on the degree of thumb hypoplasia. For hypoplasia greater than grade 3B, restoration of the thumb using pollicization of the index finger is the treatment of choice...
August 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Clotilde Strugarek-Lecoanet, Jérémie Chevrollier, Nicolas Pauchard, Alain Blum, François Dap, Gilles Dautel
PURPOSE: To evaluate outcome and function of the reconstructed basilar thumb joint after index finger pollicization in patients presenting congenital thumb deficiency. METHODS: Plain radiographs and 4-dimensional dynamic volume computed tomography scan were used to evaluate the outcome of 23 pollicizations performed on 14 children between 1996 and 2009. The mean follow-up was 8 years. Patients performed continuous movements of thumb opposition during the imaging studies...
September 2016: Journal of Hand Surgery
Kagan Ozer
Blood supply to the index finger is maintained through volar (palmar arch) and dorsal (intermetacarpal arteries) vascular networks. In traditional index finger pollicization, blood supply is maintained on the volar palmar arch. In case of index finger loss at the metacarpophalangeal joint, remaining length of the second metacarpal is often not used for pollicization because the arc of rotation is limited on digital arteries. In this report, we present a surgical technique for the transfer of the index metacarpal to the thumb on the dorsal vascular network...
September 2016: Journal of Hand Surgery
B Di Luccia, E D'Apuzzo, F Varriale, L Baccigalupi, E Ricca, A Pollice
The interaction between the enteric microbiota and intestinal cells often involves signal molecules that affect both microbial behaviour and host responses. Examples of such signal molecules are the molecules secreted by bacteria that induce quorum sensing mechanisms in the producing microorganism and signal transduction pathways in the host cells. The pentapeptide competence and sporulation factor (CSF) of Bacillus subtilis is a well characterized quorum sensing factor that controls competence and spore formation in the producing bacterium and induces cytoprotective heat shock proteins in intestinal epithelial cells...
September 2016: Beneficial Microbes
Shaheel Chummun, Neil R McLean, Peter J Anderson, Christianne van Nieuwenhoven, Irene Mathijssen, David J David
INTRODUCTION: Nager syndrome is a rare condition characterized by craniofacial and upper limb abnormalities. It is commonly mistaken for Treacher Collins syndrome, with which it shares the same craniofacial phenotype. However, patients with Treacher Collins do not exhibit hand anomalies, which are seen in patients with Nager syndrome. This paper reviews the multidisciplinary management of patients with Nager syndrome who were treated at the Australian Craniofacial Unit, Adelaide and the Erasmus Medical Centre, Rotterdam...
June 2016: Journal of Craniofacial Surgery
Orsola di Martino, Annaelena Troiano, Andrea M Guarino, Alessandra Pollice, Maria Vivo, Girolama La Mantia, Viola Calabrò
Y-box binding protein 1 (YBX-1 or YB-1) is an oncoprotein that promotes replicative immortality, tumor cell invasion and metastasis. The increase in the abundance of YB-1 in the cell or YB-1 translocation from the cytoplasm to the nucleus is characteristic of malignant cell growth. We have previously reported that ΔNp63α, a transcription factor that is known to play a pivotal role in keratinocyte proliferation and differentiation, promotes YB-1 nuclear accumulation. Here, we show that YB-1 is highly expressed in proliferating keratinocytes and is down-regulated during keratinocyte differentiation...
June 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
Carlo Salerno, Dirk Benndorf, Sabine Kluge, Luigi Leonardo Palese, Udo Reichl, Alfieri Pollice
In biological wastewater treatments, microbial populations of the so-called activated sludge work together in the abatement of pollutants. In this work, the metabolic behavior of the biomass of a lab-scale plant treating industrial pharmaceutical wastewater was investigated through a metaproteomic approach. The complete treatment process included a membrane biological reactor (MBR) coupled with an advanced oxidation process (AOP) for partial breakdown of non-biodegradable molecules. Proteins from biomass samples collected pre- and post-AOP application were investigated by two-dimensional gel electrophoresis (2DE), mass spectrometry (MS), and finally identified by database search...
July 2016: Microbial Ecology
Jean-Philippe Giot, Laurence Paek, Geneviève Mercier-Couture, Edouard Coeugniet, Joseph Bou-Merhi, Patrick Harris, Alain Danino
The authors report the case of a 30-year-old male with 52% TBSA high-voltage electrical injury of the upper half of the body. Injuries included a cervical burn with associated alteration of the left brachial plexus as well as extensive soft tissue burn of the right hand. Three months later, he developed osteomyelitis of the right thumb metacarpal bone requiring amputation proximal to the metacarpophalangeal joint. Following initial management, the patient had a permanent distal left upper extremity paralysis with nonfunctional but relatively undamaged ipsilateral hand digits...
March 30, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
Robert Pollice, Michael Schnürch
The observation and investigation of nonlinear effects in catalytic reactions provides valuable mechanistic insight. However, the applicability of this method was, until now, limited to molecules possessing chirality and therefore to asymmetric synthesis. The concept of nonlinear effects is expanded to catalytic reactions beyond asymmetric catalysis by using derivatives instead of enantiomers and by considering rates instead of enantiomeric excess. Additionally, its systematic application to investigate the mechanism of catalytic reactions is presented...
April 11, 2016: Chemistry: a European Journal
James J Lee, Jabed Seraj, Kenichiro Yoshida, Hirokazu Mizuguchi, Sandra Strychor, Jillian Fiejdasz, Tyeler Faulkner, Robert A Parise, Patrick Fawcett, Laura Pollice, Scott Mason, Jeremy Hague, Marie Croft, James Nugteren, Charles Tedder, Weijing Sun, Edward Chu, Jan Hendrik Beumer
BACKGROUND: TAS-102 is an oral fluoropyrimidine prodrug composed of trifluridine (FTD) and tipiracil hydrochloride (TPI) in a 1:0.5 ratio. FTD is a thymidine analog, and it is degraded by thymidine phosphorylase (TP) to the inactive trifluoromethyluracil (FTY) metabolite. TPI inhibits degradation of FTD by TP, increasing systemic exposure to FTD. METHODS: Patients with advanced solid tumors (6 M/2 F; median age 58 years; PS 0-1) were enrolled on this study. Patients in group A (N = 4) received 60 mg TAS-102 with 200 nCi [(14)C]-FTD, while patients in group B (N = 4) received 60 mg TAS-102 with 1000 nCi [(14)C]-TPI orally...
March 2016: Cancer Chemotherapy and Pharmacology
Morad Askari, Kevin N Christensen, Shaun Heath, Steven L Moran, Nirusha Lachman
PURPOSE: Mirror hand or ulnar dimelia is a rare and poorly studied congenital anomaly of the upper extremity. Understanding of its anatomy is limited by the rarity of the deformity and the variability in presentation. We present the case of an 80-year-old female donor with an incidental finding of mirror hand. METHODS: Medical history indicated no record of any surgical procedures or interventions to the right upper extremity suggesting that the donor had lived an independent life without the need for prosthetic aids...
September 2016: Surgical and Radiologic Anatomy: SRA
Efrén Martínez-Quintana, Fayna Rodríguez-González
Patients with mild pulmonary hypoplasia typically use to have minimal respiratory symptoms. Nonetheless, other associated anomalies such as cardiac, gastrointestinal, genitourinary, or skeletal defects may be seen. We report the case of a 17-year-old male patient with hypoplastic right lung with secondary cardiac dextroposition, an ostium secundum atrial septal defect, a hypoplastic right pulmonary artery arising from the posterior wall of the left pulmonary artery with a retrocava course, vertebral bone fusion and pollicization due to right congenital thumb absence...
2015: Pneumologia: Revista Societății Române de Pneumologie
Simona Arcuti, Alessio Pollice, Nunziata Ribecco, Gianfranco D'Onghia
We evaluate the spatiotemporal changes in the density of a particular species of crustacean known as deep-water rose shrimp, Parapenaeus longirostris, based on biological sample data collected during trawl surveys carried out from 1995 to 2006 as part of the international project MEDITS (MEDiterranean International Trawl Surveys). As is the case for many biological variables, density data are continuous and characterized by unusually large amounts of zeros, accompanied by a skewed distribution of the remaining values...
March 2016: Biometrical Journal. Biometrische Zeitschrift
Valeria Bianchini, Laura Giusti, Maurizio Malavolta, Donatella Ussorio, Maria Grazia Cifone, Leila Fabiani, Massimo Casacchia, Rita Roncone, Rocco Pollice
AIM: Observational study on a young sample at the onset of affective disorder seeking help to a dedicated service, with the aim to evaluate the age of onset, the duration of untreated psychosis (DUP), and the functional outcome at 2-year follow-up. METHODS: For 57 young people at First Episode Psychosis (FEP) of Affective Disorder, consecutively recruited to SMILE service, were collected socio-demographic and clinical (DUP, psychiatric history, age of onset) data and psychopathological (BPRS e SCL-90), perceived distress (GHQ-12) and functioning (VGF) evaluations...
July 2015: Rivista di Psichiatria
Velagala Satyanarayana Reddy, Adam Sierakowski, Madhu Periasamy, Shanmuganathan Raja Sabapathy
Soft tissue sarcomas in the thumb are rare, but often require amputation to ensure tumour clearance. This can severely impair the use of the entire upper limb and negatively impact quality of life. We describe a 63-year-old male patient with a large malignant fibrous histiocytoma affecting the base of his dominant right thumb. A wide resection of this tumour was performed, followed immediately by index finger pollicization and first web space reconstruction with a reverse pedicled posterior interosseous artery flap...
October 2015: Hand Surgery
P Vergine, R Saliba, C Salerno, G Laera, G Berardi, A Pollice
Treated wastewater reuse is increasing in semi-arid regions as a response to the effects of climate change and increased competition for natural water resources. Investigating the fate of bacterial indicators is relevant to assess their persistence in the environment and possible transfer to groundwater or to the food chain. A long-term field-scale experimental campaign and a soil column test were carried out to evaluate the fate of the fecal indicator Escherichia coli (E. coli) in a cultivated soil when contaminated water resources are used for irrigation...
November 15, 2015: Water Research
Scott H Kozin, Dan A Zlotolow
LEARNING OBJECTIVES: After reading this article, the participant should be able to: 1. Accurately diagnose congenital differences that affect the hand. 2. Develop a surgical plan for syndactyly with regard to timing of intervention to prevent progressive deformity and principles to restore the commissure. 3. List the potential complications following polydactyly reconstruction. 4. State the indications for pollicization for thumb hypoplasia. SUMMARY: Congenital conditions of the hand are commonly encountered in a pediatric hand surgery practice...
August 2015: Plastic and Reconstructive Surgery
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