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Srikripa Chandrasekaran, Andrew E Deffenbaugh, David A Ford, Eric Bailly, Neal Mathias, Dorota Skowyra
No abstract text is available yet for this article.
April 19, 2018: Molecular Cell
Sara Benedé, Evan Cody, Charuta Agashe, M Cecilia Berin
PURPOSE: It is well appreciated that mast cells (MCs) demonstrate tissue-specific imprinting, with different biochemical and functional properties between connective tissue MCs (CTMCs) and mucosal MCs (MMCs). Although in vitro systems have been developed to model these different subsets, there has been limited investigation into the functional characteristics of the 2 major MC subsets. Here, we report the immunologic characterization of 2 MCs subsets developed in vitro from bone marrow progenitors modeling MMCs and CTMCs...
May 2018: Allergy, Asthma & Immunology Research
Aliassa L Shane, Charlene R Apok, Michael J Doyle, Vanessa Y Hiratsuka, Denise A Dillard, Karen Caindec
Southcentral Foundation (SCF), a tribal health organization based in Anchorage, Alaska, operates and plans health care services in response to the priorities and tribal values of Alaska Native and American Indian (AN/AI) people, including traditional concepts of wellness, reciprocity, and working in relationship. In an effort to better incorporate AN/AI priorities and values in research dissemination, the SCF Research Department hosted the Alaska Native Health Research Forum (Forum) in May 2016. In this paper, we describe the communication strategies used by the SCF Public Relations Department, which were shared with Forum attendees, describe attendee recommendations for researchers to consider and implement, and then discuss future directions for dissemination...
2018: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
Lisa G Dirks, Jaedon P Avey, Vanessa Y Hiratsuka, Denise A Dillard, Karen Caindec, Renee F Robinson
Increased attention to diagnostic accuracy in depression screening and management within primary care has demonstrated inadequate care when patients prematurely discontinue recommended treatments such as medication and counseling. Decision-support tools can enhance the medical decision-making process. In 2010, the Southcentral Foundation (SCF) Research Department developed a stakeholder-driven decision support tool to aid in depression management. This paper describes feedback from attendees at SCF's 2016 Alaska Native Health Research Forum (Forum) regarding a dissemination product highlighting the aforementioned study...
2018: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
Jaedon P Avey, Vanessa Y Hiratsuka, Lisa G Dirks, Laurie A Moore, Barbara Beach, Douglas K Novins, Karen Caindec, Denise A Dillard
Exposure to trauma is consistently associated with co-occurrence of behavioral health disorders. Primary care settings are opportune places to screen for traumatic experiences and symptoms, as they are often the initial point of care for behavioral health concerns by the Alaska Native and American Indian (AN/AI) population. In this case study, we examine results dissemination activities at the SCF Research Department-hosted 2016 Alaska Native Health Research Forum (Forum) of a pilot study of a trauma-focused screening, brief intervention, and referral to treatment (T-SBIRT) process for AN/AI adults in primary care...
2018: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
Vanessa Y Hiratsuka, Julie A Beans, Lisa G Dirks, Jaedon P Avey, Karen Caindec, Denise A Dillard
In May 2016, Southcentral Foundation (SCF), a regional tribal health corporation based in Anchorage, Alaska convened a half-day health research forum for Alaska Native and American Indian community members to obtain feedback on communication of research findings. Thirty one individuals attended the Forum and 22 completed a pre and post survey. Respondents found the Forum to be a useful method to learn about research projects and their willingness to participate in health research reportedly increased because of the event...
2018: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
Denise A Dillard, Karen Caindec, Lisa G Dirks, Vanessa Y Hiratsuka
Alaska Native and American Indian (AN/AI) people have negative research experiences, including lack of timely, respectful, and relevant communication about research findings. Southcentral Foundation (SCF), a tribally owned and operated health care organization in Alaska, has redesigned the health care system, enacted research policies, and established a research department which uses best practices of Community Engaged Research with AN/AI people. Department staff and community members, however, perceive significant limitations in the reach of and satisfaction with ongoing engagement and dissemination efforts...
2018: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
Amartya S Banerjee, Lin Lin, Phanish Suryanarayana, Chao Yang, John E Pask
We describe a novel iterative strategy for Kohn-Sham density functional theory calculations aimed at large systems (> 1000 electrons), applicable to metals and insulators alike. In lieu of explicit diagonalization of the Kohn-Sham Hamiltonian on every self-consistent field (SCF) iteration, we employ a two-level Chebyshev polynomial filter based complementary subspace strategy to: 1) compute a set of vectors that span the occupied subspace of the Hamiltonian; 2) reduce subspace diagonalization to just partially occupied states; and 3) obtain those states in an efficient, scalable manner via an inner Chebyshev-filter iteration...
April 16, 2018: Journal of Chemical Theory and Computation
Marieke Goedhart, Anne Cornelissen, Carlijn Kuijk, Sulima Geerman, Marion Kleijer, Jaap D van Buul, Stephan Huveneers, Marc Raaijmakers, Howard A Young, Monika C Wolkers, Carlijn Voermans, Martijn A Nolte
Bone marrow (BM) mesenchymal stromal cells (MSCs) provide micro-environmental support to hematopoietic stem and progenitor cells (HSPCs). Culture-expanded MSCs are interesting candidates for cellular therapies due to their immunosuppressive and regenerative potential which can be further enhanced by pre-treatment with interferon-gamma (IFN-γ). However, it remains unknown whether IFN-γ can also influence hematopoietic support by BM-MSCs. Here, we elucidate the impact of IFN-γ on the hematopoietic support of BM-MSCs...
March 12, 2018: Stem Cells and Development
Keyvan Mostofi, Reza Karimi Khouzani
Background: The incidence of Disc herniation is about 2-3% of population. Each year 300,000 procedures performed in USA. The aim of this paper is to describe the utility of endoscopic procedure in treatment of lumbar disc herniation. Methods: We operated 359 patients from September 2013 to December 2016 for lumbar disk herniation by Endoscopic DESTANDAU method (EDM). The average length of surgery was 47 min. We operated 211 male and 148 female patients. In average, patients had pain for 4...
March 2018: Journal of Clinical Orthopaedics and Trauma
Chengjian Cao, Liang Li, Huiming Li, Xueling He, Wu Geng, Yu Xiaoqin
A physical stimuli, it has been reported that cyclic tensile strain can promote bone marrow-derived mesenchymal stem cells (BMSCs) to differentiate into cardiomyocytes, but the underlying mechanisms have been poorly elucidated so far. Here, we used a mimicking loading strain, cyclic biaxial tensile strain (CBTS), and found it can promote BMSCs to differentiate into cardiomyocytes. When the CBTS were loaded, the cells expressed cardiac-specific markers GATA4, TNNT2, MEF-2c, and Cx43, meanwhile we found miR-27a decreased and stem cell factor (SCF) increased...
April 5, 2018: International Journal of Biochemistry & Cell Biology
C Laldinsangi, B Senthilkumaran
C-kit receptor is a member of a family of growth factor receptors that have tyrosine kinase activity, and are involved in the transduction of growth regulatory signals across plasma membrane by activation of its ligand, kitl/scf. The present study analysed mRNA and protein expression profiles of c-kit in the gonads of catfish, Clarias gariepinus, using real time PCR, in situ hybridization and immunohistochemistry. Tissue distribution analysis revealed higher expression mainly in the catfish gonads. Ontogeny studies showed minimal expression during early developmental stages and highest during 50-75 days post hatch, and the dimorphic expression in gonads decreased gradually till adulthood, which might suggest an important role for this gene around later stages of sex differentiation and gonadal development...
April 3, 2018: General and Comparative Endocrinology
Meng Ji, Shuang Tang, Wenhua Pei, Mingming Ning, Yuehui Ma, Xiangchen Li, Weijun Guan
In vitro production of functional spermatids has special significance in the research of spermatogenesis and the treatment of male infertility. Primordial germ cells (PGCs) are the precursors of oocyte and sperm, which generate the totipotent cells. Studies have shown that PGCs have the potential ability to develop meiotic spermatids in vitro. Here we have shown that retinoic acid (RA) leads to PGC differentiation, and SCF can improve the efficiency of induction. We indicate an efficient approach to produce haploid spermatids from chicken PGCs in the presence of RA and stem cell factor (SCF)...
March 30, 2018: International Journal of Molecular Medicine
Ali Kadivar, Mohamed Ibrahim Noordin, Arya Aditya, Behnam Kamalidehghan, Ehsan Taghizadeh Davoudi, Reihaneh Sedghi, Hamid Akbari Javar
Imatinib mesylate is an anti‑neoplastic targeted chemotherapeutic agent, which can inhibit tyrosine kinase receptors, including BCR‑ABL, platelet‑derived growth factor receptors (PDGFRs) and c‑Kit. Cellular processes, including differentiation, proliferation and survival are regulated by these receptors. The present study aimed to evaluate the antiproliferative effects of imatinib mesylate, and its effects on apoptotic induction and cell cycle arrest in breast cancer cell lines. In addition, the study aimed to determine whether the effects of this drug were associated with the mRNA and protein expression levels of PDGFR‑β, c‑Kit, and their corresponding ligands PDGF‑BB and stem cell factor (SCF), which may potentially modulate cell survival and proliferation...
March 27, 2018: International Journal of Molecular Medicine
R Swapna Sonale, K Ramalakshmi, K Udaya Sankar
Extraction process employing Supercritical fluid carbon dioxide (SCF) yields bioactive compounds near natural forms without any artifact formation. Neem seed was subjected to SCF at different temperatures and pressure conditions. These extracts were partitioned to separate volatile fraction and were analyzed by Gas Chromatography-Mass spectroscopy along with the volatiles extracted by the hydro-distillation method. Experimental results show that there is a significant effect of pressure and temperature on isolation of a number of volatile compounds as well as retention of biologically active compounds...
April 2018: Journal of Food Science and Technology
Chung-Ping Liao, Reid C Booker, Jean-Philippe Brosseau, Zhiguo Chen, Juan Mo, Edem Tchegnon, Yong Wang, D Wade Clapp, Lu Q Le
Neurofibromatosis type 1 associates with multiple neoplasms and the Schwann cell tumor neurofibroma is the most prevalent. A hallmark feature of neurofibroma is mast cell infiltration which is recruited by chemoattractant stem cell factor (SCF) that has been suggested to sustain neurofibroma tumorigenesis. In this study, using new genetically engineered Scf mice, we decipher the contributions of tumor-derived SCF and mast cells to neurofibroma development. We demonstrate that mast cell infiltration is dependent on SCF from tumor Schwann cells...
March 29, 2018: Journal of Clinical Investigation
Kanaka Durga Devi Gorrepati, Wei He, Blaz Lupse, Ting Yuan, Kathrin Maedler, Amin Ardestani
Loss of pancreatic β-cell function and/or mass is a central hallmark of all forms of diabetes but its molecular basis is incompletely understood. β-cell apoptosis contributes to the reduced β-cell mass in diabetes. Therefore, the identification of important signaling molecules that promote β-cell survival in diabetes could lead to a promising therapeutic intervention to block β-cell decline during development and progression of diabetes. In the present study, we identified F-box protein 28 (FBXO28), a substrate-recruiting component of the Skp1-Cul1-F-box (SCF) ligase complex, as a regulator of pancreatic β-cell survival...
March 24, 2018: International Journal of Molecular Sciences
Kang Guo, Honglin Zhang, Shujun Cao, Chen Gu, Huating Zhou, Jie Li, Yingguang Zhu
A novel and efficient copper-catalyzed cascade cyclization/trifluoromethylthiolation of unactivated olefins has been achieved with the stable and readily available AgSCF3 as the SCF3 source. A range of SCF3 -substituted pyrrolines have been easily obtained under mild conditions in good yields via the present process. This method represents a facile and rapid access to valuable pyrrolines with fluorine-containing groups, and it is amenable to gram-scale synthesis.
March 27, 2018: Organic Letters
Yaman Hamade, Ahmad El Sobbahi
Our investigation is devoted to the theoretical study of the low-lying electronic structure of the LaCl molecule by using ab initio quantum methods. We are concerned with several methods such as the complete active space-self consistent field (CAS-SCF) and the multi reference of configuration interaction (MRCI + Q) methods. These methods are applied for the purpose of drawing the potential energy curves (PECs) and calculating the molecular spectroscopic constants for a given number of electronic states of singlet and triplet multiplicity...
March 22, 2018: Journal of Molecular Modeling
Dan-Dan Yin, Jun-Hui Luo, Zhu-Ye Zhao, Ying-Jun Liao, Ying Li
Renal interstitial fibrosis is a final pathway that is observed in various types of kidney diseases, including diabetic kidney disease (DKD). The present study investigated the effect of tranilast on renal interstitial fibrosis and the association between its role and mast cell infiltration in a rat model of DKD. A total of 30 healthy 6‑week‑old male Sprague‑Dawley rats were randomly divided into the following four groups: Normal control group; DKD model group; low‑dose tranilast group (200 mg/kg/day); and high‑dose tranilast group (400 mg/kg/day)...
May 2018: Molecular Medicine Reports
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