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https://www.readbyqxmd.com/read/28540289/stem-cell-induced-biobridges-as-possible-tools-to-aid-neuroreconstruction-after-cns-injury
#1
REVIEW
Jea Y Lee, Kaya Xu, Hung Nguyen, Vivian A Guedes, Cesar V Borlongan, Sandra A Acosta
Notch-induced mesenchymal stromal cells (MSCs) mediate a distinct mechanism of repair after brain injury by forming a biobridge that facilitates biodistribution of host cells from a neurogenic niche to the area of injury. We have observed the biobridge in an area between the subventricular zone and the injured cortex using immunohistochemistry and laser capture. Cells in the biobridge express high levels of extracellular matrix metalloproteinases (MMPs), specifically MMP-9, which co-localized with a trail of MSCs graft...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28537242/-murine-and-human-hematopoietic-progenitor-cultures-grown-on-stromal-layers-expressing-notch-ligands
#2
A A Raevskaya, M V Savvateeva, S S Bukhinnik, O F Kandarakov, P A Butylin, S V Zhuk, A M Demin, V P Krasnov A Y Zaritsky, A V Belyavsky
The ex vivo maintenance and expansion of hematopoietic stem cells and early progenitors is necessary for the successful treatment of hematopoietic and immune diseases. Multiple attempts to improve the expansion of hematopoietic stem cells (HSCs) by their cultivation in the presence of growth factor cocktails have so far failed. Novel approaches aimed at conserving the earliest precursors in their undifferentiated state are needed. These approaches should take into account local regulatory factors that are present in the HSC microenvironment and the three-dimensional architecture of their niche...
March 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28535682/ctrp6-regulates-porcine-adipocyte-proliferation-and-differentiation-by-the-adipor1-mapk-signaling-pathway
#3
Wenjing Wu, Jin Zhang, Chen Zhao, Yunmei Sun, Pang Wei-Jun, Gongshe Yang
Intramuscular fat (IMF) and subcutaneous fat (SCF), which are modulated by adipogenesis of intramuscular and subcutaneous adipocytes, play key roles in pork quality. C1q/tumor necrosis factor-related protein 6 (CTRP6), an adipokine , plays an important role in the differentiation of 3T3-L1 cells. However, the effect and regulatory mechanisms of CTRP6 on porcine adipogenesis, and whether CTRP6 has the same effect on intramuscular and subcutaneous adipocytes are still unknown. Here, we found that CTRP6 significantly inhibited both adipocyte proliferation assessed by proliferative marker expression, but CTRP6 decreased the proliferation rate of intramuscular adipocytes (IM) to a greater extent than subcutaneous adipocytes (SC)...
May 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28515316/dna-damage-induced-degradation-of-exo1-limits-dna-end-resection-to-ensure-accurate-dna-repair
#4
Nozomi Tomimatsu, Bipasha Mukherjee, Janelle Louise Harris, Francesca Ludovica Boffo, Molly Hardebeck, Patrick Ryan Potts, Kum Kum Khanna, Sandeep Burma
End resection of DNA double-strand breaks (DSBs) to generate 3'-single-stranded DNA facilitates DSB repair via error-free homologous recombination (HR) while stymieing repair by the error-prone non-homologous end joining (NHEJ) pathway. Activation of DNA end resection involves phosphorylation of the 5' to 3' exonuclease EXO1 by the phosphoinositide 3-kinase-like kinases ATM and ATR, and by the cyclin-dependent kinases 1 and 2. After activation, EXO1 must also be restrained in order to prevent over-resection which is known to hamper optimal HR and trigger global genomic instability...
May 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28513991/immunoprotective-effect-of-chitosan-particles-on-hymenolepis-nana-infected-mice
#5
Mahmoud Abdel-Latif, Gamal El-Shahawi, Shawky M Aboelhadid, Heba Abdel-Tawab
Hymenolepis nana is the most commonly known intestinal cestode infecting mainly human. The present study aimed to investigate the potential effect of chitosan particles (CSP) to enhance the immune system against H. nana infection. Determination of worm burden, egg output, histopathological changes, oxidative stress markers (lipid peroxidation & reduced glutathione), goblet (GCs) and mucosal mast cells (MMCs) counts in intestinal ileum were performed. In addition, levels of intestinal mRNA expression of interleukin (IL)-4, IL-9, stem cell factor (SCF), type I & II interferons (IFN)-α/ γ, tumor necrosis factor (TNF)-α, mucin 2 (MUC2), and inducible nitric oxide synthase (iNOs) were investigated using real-time PCR...
May 17, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28512235/identifying-the-niche-controlling-melanocyte-differentiation
#6
REVIEW
Manuel Zocco, Cédric Blanpain
Melanocytes present in hair follicles are responsible for their pigmentation. Melanocyte differentiation and hair pigmentation depend on the stem cell factor (SCF)/c-Kit signaling pathway, but the niche that regulates melanocyte differentiation is not well characterized. In this issue of Genes & Development, Liao and colleagues (pp. 744-756) identify Krox20(+)-derived cells of the hair shaft as the niche and the essential source of SCF required for melanocyte maturation. This study delineates the niche factors regulating melanocyte differentiation and hair pigmentation and opens up new avenues to further characterize the cross-talk between the hair follicle and melanocytes that controls melanocyte maintenance and differentiation...
April 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28505565/dft-and-td-dft-theoretical-studies-on-photo-induced-electron-transfer-process-on-cefamandole-c60-nano-complex
#7
Avat Arman Taherpour, Morteza Jamshidi, Omid Rezaei
The C60 fullerene displays a considerable electronegativity. It has a unique photophysical and electrochemical behavior that can be used as a suitable drug carrier. In the present study, the interaction of C60 fullerene as an electron recipient with the Cefamandole antibiotic was investigated in both ground and excited states using DFT and TD-DFT methods. The study of the interaction of C60 and Cefamandole via electron localization function (ELF) and reduced density gradient (RDG) revealed that the complex formation is of van der Waals type...
April 27, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28500896/a-microrna-ubiquitin-ligase-feedback-loop-regulates-slug-mediated-invasion-in-breast-cancer
#8
Rajesh Kumar Manne, Yashika Agrawal, Anil Bargale, Asha Patel, Debasish Paul, Neha Anilkumar Gupta, Srikanth Rapole, Vasudevan Seshadri, Deepa Subramanyam, Praveenkumar Shetty, Manas Kumar Santra
The transformation of a normal cell to cancer requires the derail of multiple pathways. Normal signaling in a cell is regulated at multiple stages by the presence of feedback loops, calibration of levels of proteins by their regulated turnover, and posttranscriptional regulation, to name a few. The tumor suppressor protein FBXO31 is a component of the SCF E3 ubiquitin ligase and is required to arrest cells at G1 following genotoxic stresses. Due to its growth-suppression activity, it is underexpressed in many cancers...
May 9, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28494021/rice-black-streaked-dwarf-virus-p7-2-forms-a-scf-complex-through-binding-to-oryza-sativa-skp1-like-proteins-and-interacts-with-gid2-involved-in-the-gibberellin-pathway
#9
Tao Tao, Cui-Ji Zhou, Qian Wang, Xiang-Ru Chen, Qian Sun, Tian-Yu Zhao, Jian-Chun Ye, Ying Wang, Zong-Ying Zhang, Yong-Liang Zhang, Ze-Jian Guo, Xian-Bing Wang, Da-Wei Li, Jia-Lin Yu, Cheng-Gui Han
As a core subunit of the SCF complex that promotes protein degradation through the 26S proteasome, S-phase kinase-associated protein 1 (SKP1) plays important roles in multiple cellular processes in eukaryotes, including gibberellin (GA), jasmonate, ethylene, auxin and light responses. P7-2 encoded by Rice black streaked dwarf virus (RBSDV), a devastating viral pathogen that causes severe symptoms in infected plants, interacts with SKP1 from different plants. However, whether RBSDV P7-2 forms a SCF complex and targets host proteins is poorly understood...
2017: PloS One
https://www.readbyqxmd.com/read/28492325/theoretical-study-of-the-solvation-effect-on-the-reductive-reaction-of-vinylene-carbonate-in-the-electrolyte-solution-of-lithium-ion-batteries
#10
Kento Kasahara, Hiroshi Nakano, Hirofumi Sato
Carbon monoxide generation reaction of vinylene carbonate (VC) in the electrolyte solution of lithium ion batteries (ethylene carbonate (EC) and 1.0 M LiClO4/EC) is studied using the RISM-SCF-SEDD method, a hybrid methodology of statistical mechanics for molecular liquids and quantum chemistry. The analytical treatment of the solvent and lithium salt enables us to treat the complicated composition of the solution such as the concentration of the salt which is difficult for the methods based on the molecular dynamics (MD) simulation...
May 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28485978/second-order-self-consistent-field-density-matrix-renormalization-group
#11
Yingjin Ma, Stefan Knecht, Sebastian Keller, Markus Reiher
We present a matrix-product state (MPS)-based quadratically convergent density-matrix renormalization group self-consistent-field (DMRG-SCF) approach. Following a proposal by Werner and Knowles (JCP 82, 5053, (1985)), our DMRG-SCF algorithm is based on a direct minimization of an energy expression which is correct to second-order with respect to changes in the molecular orbital basis. We exploit a simultaneous optimization of the MPS wave function and molecular orbitals in order to achieve quadratic convergence...
May 9, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28485938/excitation-energies-of-uo2-2-nuo-and-nun-based-on-equation-of-motion-coupled-cluster-theory-with-spin-orbit-coupling
#12
Shuo Zhang, Fan Wang
Obtaining reliable excitation energies of the isoelectronic series, UO2(2+), NUO(+), and UN2, is a challenge in quantum chemistry calculations due to importance of electron correlation and spin-orbit coupling (SOC). Vertical spin-free and spin-orbit coupled excitation energies of these molecules are calculated in this work using equation-of-motion coupled-cluster approach at the CC singles and doubles level (EOM-CCSD). SOC is included in post-SCF calculations and this treatment has been shown to provide SOC effects with high accuracy for heavy elements...
May 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28483055/the-improvement-of-salt-tolerance-in-transgenic-tobacco-by-overexpression-of-wheat-f-box-gene-tafba1
#13
Zhongxian Zhao, Guangqiang Zhang, Shumei Zhou, Yuanqing Ren, Wei Wang
F-box protein is a major subunit of the Skp1-Cullin-F-box (SCF) complex. We previously isolated an F-box gene from wheat, TaFBA1, and here we show that overexpression of TaFBA1 in transgenic plants under salt stress increases germination rate, root elongation, and biomass accumulation compared with WT plants. Improvements in the photosynthetic rate and its corresponding parameters were also found in the transgenic plants. These results suggest that overexpression of TaFBA1 improves salt stress tolerance in transgenic tobacco...
June 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28481685/a-case-series-of-imatinib-induced-generalized-hypopigmentation-and-progression-of-existing-acquired-dermal-melanocytosis
#14
Wai Leong Kok, Qiping Chen, Siong See Joyce Lee, Sze Hon Chua, See Ket Ng
Imatinib mesylate is a tyrosine kinase inhibitor used in the treatment of oncological conditions, including chronic myeloid leukemia and gastrointestinal stromal tumors. The most frequent dermatological side effect reported is pigmentary abnormalities. We report a case series of three Asian Chinese females with pre-existing acquired dermal melanocytosis that progressed after initiation of imatinib treatment, and concurrently developed generalized hypopigmentation of the skin. All three patients had similar histological findings on skin biopsy...
May 8, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28479304/understanding-hematopoietic-stem-cell-development-through-functional-correlation-of-their-proliferative-status-with-the-intra-aortic-cluster-architecture
#15
Antoniana Batsivari, Stanislav Rybtsov, Celine Souilhol, Anahi Binagui-Casas, David Hills, Suling Zhao, Paul Travers, Alexander Medvinsky
During development, hematopoietic stem cells (HSCs) emerge in the aorta-gonad-mesonephros (AGM) region through a process of multi-step maturation and expansion. While proliferation of adult HSCs is implicated in the balance between self-renewal and differentiation, very little is known about the proliferation status of nascent HSCs in the AGM region. Using Fucci reporter mice that enable in vivo visualization of cell-cycle status, we detect increased proliferation during pre-HSC expansion followed by a slowing down of cycling once cells start to acquire a definitive HSC state, similar to fetal liver HSCs...
May 3, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28475177/the-role-of-hybrid-ubiquitin-chains-in-the-myd88-and-other-innate-immune-signalling-pathways
#16
REVIEW
Philip Cohen, Sam Strickson
The adaptor protein MyD88 is required for signal transmission by toll-like receptors and receptors of the interleukin-1 family of cytokines. MyD88 signalling triggers the formation of Lys63-linked and Met1-linked ubiquitin (K63-Ub, M1-Ub) chains within minutes. The K63-Ub chains, which are formed by the E3 ubiquitin ligases TRAF6, Pellino1 and Pellino2, activate TAK1, the master kinase that switches on mitogen-activated protein (MAP) kinase cascades and initiates activation of the canonical IκB kinase (IKK) complex...
May 5, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28469796/low-dose-radiation-modulates-human-mesenchymal-stem-cell-proliferation-through-regulating-cdk-and-rb
#17
Lei Yang, Ziling Liu, Chen Chen, Xiaofeng Cong, Zhi Li, Shasha Zhao, Meng Ren
Low-dose radiation (LDR) has been known to stimulate cell proliferation. The effect of LDR on human bone marrow mesenchymal stem cells (BMSCs), however, remains to be determined. The current study, therefore, aimed to investigate the effect of LDR on human BMSC proliferation and its mechanisms. To accomplish this, human BMSCs were isolated from ribs and cultured with or without exposition to LDR (75 mGy) for 24 h. Cell proliferation was assessed by MTT assay, the cytokines secreted by the BMSCs were quantified by ELISA, and the proteins associated with cell proliferation and cell cycle were evaluated by immunoblot analysis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28466425/iterative-stochastic-subspace-self-consistent-field-method
#18
Pierre-François Loos, Jean-Louis Rivail, Xavier Assfeld
We propose a new self-consistent field (SCF) algorithm based on an iterative, partially stochastic "Divide & Conquer"-type approach. This new SCF algorithm is a simple variant of the usual SCF procedure and can be easily implemented in parallel. A detailed description of the algorithm is reported. We illustrate this new method on one-dimensional hydrogen chains and three-dimensional hydrogen clusters. Graphical Abstract Stochastic partition of the molecular orbitals.
June 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28465357/identification-of-hair-shaft-progenitors-that-create-a-niche-for-hair-pigmentation
#19
Chung-Ping Liao, Reid C Booker, Sean J Morrison, Lu Q Le
Hair differentiates from follicle stem cells through progenitor cells in the matrix. In contrast to stem cells in the bulge, the identities of the progenitors and the mechanisms by which they regulate hair shaft components are poorly understood. Hair is also pigmented by melanocytes in the follicle. However, the niche that regulates follicular melanocytes is not well characterized. Here, we report the identification of hair shaft progenitors in the matrix that are differentiated from follicular epithelial cells expressing transcription factor KROX20...
May 2, 2017: Genes & Development
https://www.readbyqxmd.com/read/28461484/protein-mediated-viral-latency-is-a-novel-mechanism-for-merkel-cell-polyomavirus-persistence
#20
Hyun Jin Kwun, Yuan Chang, Patrick S Moore
Viral latency, in which a virus genome does not replicate independently of the host cell genome and produces no infectious particles, is required for long-term virus persistence. There is no known latency mechanism for chronic small DNA virus infections. Merkel cell polyomavirus (MCV) causes an aggressive skin cancer after prolonged infection and requires an active large T (LT) phosphoprotein helicase to replicate. We show that evolutionarily conserved MCV LT phosphorylation sites are constitutively recognized by cellular Fbw7, βTrCP, and Skp2 Skp-F-box-cullin (SCF) E3 ubiquitin ligases, which degrade and suppress steady-state LT protein levels...
May 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
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