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https://www.readbyqxmd.com/read/29054992/suppression-of-adaptive-responses-to-targeted-cancer-therapy-by-transcriptional-repression
#1
Maria Rusan, Kapsok Li, Yvonne Li, Camilla L Christensen, Brian J Abraham, Nicholas Kwiatkowski, Kevin A Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li, Kevin Rhee, Haikuo Zhang, Wankun Chen, Hideki Terai, Tiffany Tavares, Alan L Leggett, Tianxia Li, Yichen Wang, Tinghu Zhang, Tae-Jung Kim, Sook-Hee Hong, Neermala Poudel-Neupane, Michael Silkes, Tenny Mudianto, Li Tan, Takeshi Shimamura, Matthew Meyerson, Adam J Bass, Hideo Watanabe, Nathanael S Gray, Richard A Young, Kwok-Kin Wong, Peter S Hammerman
Acquired drug resistance is a major factor limiting the effectiveness of targeted cancer therapies. Targeting tumors with kinase inhibitors induces complex adaptive programs that promote the persistence of a fraction of the original cell population, facilitating the eventual outgrowth of inhibitor-resistant tumor clones. We show that the addition of a newly identified CDK7/12 inhibitor, THZ1, to targeted therapy enhances cell killing and impedes the emergence of drug-resistant cell populations in diverse cellular and in vivo cancer models...
October 20, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29042799/asthma-symptoms-mannitol-reactivity-and-exercise-induced-bronchoconstriction-in-adolescent-swimmers-versus-tennis-players
#2
Kerstin Romberg, Ellen Tufvesson, Leif Bjermer
BACKGROUND: Strenuous physical activity at an elite level is associated with an increased risk for asthma and, in some sports, also prevalence of allergies. The aim of this study was to investigate the prevalence of asthma and allergy among elite swimmers and tennis players and compare airway hyperreactivity to mannitol and exercise. MATERIALS AND METHODS: One hundred and one adolescent swimmers and 86 tennis players answered a questionnaire about respiratory symptoms and allergy and performed mannitol challenge and sport-specific exercise challenge...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29039723/glenohumeral-internal-rotation-deficit-in-table-tennis-players
#3
Danilo Harudy Kamonseki, Luísa Cedin, Fernanda Assis Paes Habechian, Guigliano Franco Piccolomo, Paula Rezende Camargo
Table tennis requires rapid and extreme movements that may result in shoulder adaptations, such as glenohumeral internal rotation deficit, which is a risk factor for several injuries. This study compared range of motion of internal and external rotation and total rotation motion of glenohumeral joint between dominant and non-dominant shoulders of table tennis players. This is a cross-sectional observational study. Twenty healthy male table tennis players that were enrolled in an official table tennis league took part in this study (mean age: 22...
October 17, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29037620/the-effects-of-strengthening-exercises-for-wrist-flexors-and-extensors-on-muscle-strength-and-counter-stroke-performance-in-amateur-table-tennis-players
#4
Raoyrin Chanavirut, Nontawit Udompanich, Phraophimon Udom, Ponlapat Yonglitthipagon, Wanida Donpunha, Saowanee Nakmareong, Juinichiro Yamauchi
This study aims to evaluate the effects of strengthening exercises on wrist flexor and extensor strength, hand grip strength, and counter-stroke performance. Thirty amateur table tennis players were recruited and randomly allocated into two groups: the control and the training group (n = 15/group). Pre- and post-data were collected. The training group performed home exercises for six weeks using a bucket filled with water, while the controls were asked to keep their lifestyle as usual. The general characteristics were no significant differences...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29021912/a-study-of-intensity-fatigue-and-precision-in-two-specific-interval-trainings-in-young-tennis-players-high-intensity-interval-training-versus-intermittent-interval-training
#5
David Suárez Rodríguez, Miguel Del Valle Soto
BACKGROUND: The aim of this study is to find the differences between two specific interval exercises. We begin with the hypothesis that the use of microintervals of work and rest allow for greater intensity of play and a reduction in fatigue. METHODS: Thirteen competition-level male tennis players took part in two interval training exercises comprising nine 2 min series, which consisted of hitting the ball with cross-court forehand and backhand shots, behind the service box...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29020659/3d-gait-analysis-with-and-without-an-orthopedic-walking-boot
#6
H Gulgin, K Hall, A Luzadre, E Kayfish
INTRODUCTION: Orthopedic walking boots have been widely used in place of traditional fiberglass casts for a variety of orthopedic injuries and post-surgical interventions. These walking boots create a leg length discrepancy (LLD). LLD has been shown to alter the kinematics and kinetics of gait and are associated with lumbar and lower limb conditions such as: foot over pronation, low back pain, scoliosis, and osteoarthritis of the hip and knee joints. Past gait analyses research with orthopedic boots is limited to findings on the ipsilateral limb...
October 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28990575/a-systematic-review-of-the-concept-and-clinical-applications-of-bone-marrow-aspirate-concentrate-in-tendon-pathology
#7
Mohamed A Imam, James Holton, Saman Horriat, Ahmed S Negida, Florian Grubhofer, Rohit Gupta, Ali Narvani, Martyn Snow
Tendon pathologies are a group of musculoskeletal conditions frequently seen in clinical practice. They can be broadly classified into traumatic, degenerative and overuse-related tendinopathies. Rotator cuff tears, Achilles tendinopathy and tennis elbow are common examples of these conditions. Conventional treatments have shown inconsistent outcomes and might fail to provide satisfactory clinical improvement. With the growing trend towards the use of mesenchymal stem cells (MSCs) in other branches of medicine, there is an increasing interest in treating tendon pathologies using the bone marrow MSC...
2017: SICOT-J
https://www.readbyqxmd.com/read/28968153/exergaming-for-individuals-with-spinal-cord-injury-a-pilot-study
#8
Maziah Mat Rosly, Mark Halaki, Hadi Mat Rosly, Victor Cuesta, Nazirah Hasnan, Glen M Davis, Ruby Husain
OBJECTIVE: Commercially available exergames that are for wheelchair-bound individuals with spinal cord injury (SCI) are scarce. This study sought to identify exergames for individuals with SCI that are "dose-potent" for health benefits. MATERIALS AND METHODS: Six participants with SCI were recruited for a pilot study to investigate the exercise intensity of selected exergames (Move Tennis, Move Boxing, and Move Gladiator Duel) for the potential to improve health...
October 2017: Games for Health
https://www.readbyqxmd.com/read/28961061/sport-expertise-in-perception-action-coupling-revealed-in-a-visuomotor-tracking-task
#9
Maroua Mallek, Nicolas Benguigui, Matt Dicks, Regis Thouvarecq
We compared the visuomotor coordination of tennis players with different levels of expertise (Super-Experts, Experts and Non-Experts) in a visuomotor tracking (VMT) task. Participants were asked to track a moving target which could rebound on the sides of a 2D screen. Results indicated that the VMT task allowed the discrimination of expertise. Multiple regression analysis revealed that performance could be explained by the temporal adaptation of participants to rebounds and the number of movement adaptations...
September 29, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28959200/open-and-closed-skill-exercise-interventions-produce-different-neurocognitive-effects-on-executive-functions-in-the-elderly-a-6-month-randomized-controlled-trial
#10
Chia-Liang Tsai, Chien-Yu Pan, Fu-Chen Chen, Yu-Ting Tseng
This study aimed to explore the effects of open- and closed-skill exercise interventions on the neurocognitive performance of executive functions in the elderly. Sixty-four healthy elderly males were randomly assigned to either a closed-skill (bike riding or brisk walking/jogging, n = 22), open-skill (table tennis, n = 21), or control (n = 21) group. Various neuropsychological [e.g., accuracy rates (AR) and reaction time (RT)] and electrophysiological [e.g., event-related potential (ERP) P3 component] measures were assessed during a variant of the task-switching paradigm, as well as an N-back task at baseline and after either a 6-month exercise intervention or control period...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28952852/effects-of-self-myofascial-release-on-shoulder-function-and-perception-in-adolescent-tennis-players
#11
Julien Le Gal, Mickael Begon, Benoit Gillet, Isabelle Rogowski
CONTEXT: Tennis induces a decreased internal rotation range of motion at the dominant glenohumeral joint. The effects of self-myofascial release have not yet been investigated to restore glenohumeral range of motion. OBJECTIVE: This study aimed at investigating the effects of self-myofascial release on the shoulder function and perception in adolescent tennis players. DESIGN: Test-retest design. SETTING: Tennis training sport facilities...
September 27, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28951813/spontaneous-reoccurrence-of-scooping-a-wild-tool-use-behaviour-in-na%C3%A3-ve-chimpanzees
#12
Elisa Bandini, Claudio Tennie
Modern human technological culture depends on social learning. A widespread assumption for chimpanzee tool-use cultures is that they, too, are dependent on social learning. However, we provide evidence to suggest that individual learning, rather than social learning, is the driver behind determining the form of these behaviours within and across individuals. Low-fidelity social learning instead merely facilitates the reinnovation of these behaviours, and thus helps homogenise the behaviour across chimpanzees, creating the population-wide patterns observed in the wild (what here we call "socially mediated serial reinnovations")...
2017: PeerJ
https://www.readbyqxmd.com/read/28937802/epidemiology-of-stress-fractures-in-collegiate-student-athletes-2004-2005-through-2013-2014-academic-years
#13
Katherine H Rizzone, Kathryn E Ackerman, Karen G Roos, Thomas P Dompier, Zachary Y Kerr
CONTEXT:   Stress fractures are injuries caused by cumulative, repetitive stress that leads to abnormal bone remodeling. Specific populations, including female athletes and endurance athletes, are at higher risk than the general athletic population. Whereas more than 460 000 individuals participate in collegiate athletics in the United States, no large study has been conducted to determine the incidence of stress fractures in collegiate athletes. OBJECTIVE:   To assess the incidence of stress fractures in National Collegiate Athletic Association (NCAA) athletes and investigate rates and patterns overall and by sport...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28928115/stretching-the-evidence-behind-tennis-elbow-mobile-app-user-guide
#14
Luke J Heales, Michele Lastella, Brooke K Coombes, Bill Vicenzino
No abstract text is available yet for this article.
September 19, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28922090/microsaccades-and-interest-areas-during-free-viewing-sport-task
#15
Alessandro Piras, Milena Raffi, Monica Perazzolo, Ivan Malagoli Lanzoni, Salvatore Squatrito
Microsaccades are important fixation eye movements for visual scene perception. Compared to novices, athletes make fewer fixations of longer duration toward limited interest areas crucial for action prediction. Thus, our aim was to study the microsaccade features during those fixations. Gaze behaviour of expert and novice table tennis players was recorder during a task in which subjects were instructed to predict the direction of the ball after the opponent's throw. Three interest areas from the opponent's body and one from the ball trajectory were identified...
September 18, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28920966/-prevention-of-cardiovascular-diseases-prophylactic-program-in-a-selected-enterprise
#16
Jadwiga Siedlecka, Elżbieta Gadzicka, Agata Szyjkowska, Patryk Siedlecki, Wiesław Szymczak, Teresa Makowiec-Dąbrowska, Alicja Bortkiewicz
BACKGROUND: In Poland cardiovascular diseases (CVD), classified as work-related diseases, are responsible for 25% of disability and cause 50% of all deaths, including 26.9% of deaths in people aged under 65 years. The aim of the study was to analyze employee expectations regarding CVD- oriented prophylactic activities in the selected enterprise. MATERIAL AND METHODS: A questionnaire, developed for this study, consists of: socio-demographic data, job characteristics, occupational factors, and questions about the respondents' expectations concerning the prevention program...
September 18, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28920488/broomsticks-tennis-balls-and-locking-plates
#17
Jack Schuberth
No abstract text is available yet for this article.
October 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28919493/heat-stress-incident-prevalence-and-tennis-matchplay-performance-at-the-australian-open
#18
Matthew T Smith, Machar Reid, Stephanie Kovalchik, Tim O Woods, Rob Duffield
OBJECTIVES: To examine the association of wet bulb globe temperature (WBGT) with the occurrence of heat-related incidents and changes in behavioural and matchplay characteristics in men's Grand Slam tennis. DESIGN: On-court calls for trainers, doctors, cooling devices and water, post-match medical consults and matchplay characteristic data were collected from 360 Australian Open matches (first 4 rounds 2014-2016). METHODS: Data were referenced against estimated WBGT and categorised into standard zones...
September 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28905685/helping-coaches-apply-the-principles-of-representative-learning-design-validation-of-a-tennis-specific-practice-assessment-tool
#19
Lyndon Krause, Damian Farrow, Machar Reid, Tim Buszard, Ross Pinder
Representative Learning Design (RLD) is a framework for assessing the degree to which experimental or practice tasks simulate key aspects of specific performance environments (i.e. competition). The key premise being that when practice replicates the performance environment, skills are more likely to transfer. In applied situations, however, there is currently no simple or quick method for coaches to assess the key concepts of RLD (e.g. during on-court tasks). The aim of this study was to develop a tool for coaches to efficiently assess practice task design in tennis...
September 14, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28895466/lower-limb-muscle-activity-during-table-tennis-strokes
#20
Yann Le Mansec, Sylvain Dorel, François Hug, Marc Jubeau
This study aimed to compare the muscle activity of lower limbs across typical table tennis strokes. Fourteen high-level players participated in this study in which five typical strokes (backhand top, forehand top, forehand spin, forehand smash, flick) were analysed. Surface electromyography activity (EMG) of eight muscles was recorded (gluteus maximus, biceps femoris, vastus medialis, vastus lateralis, rectus femoris, gastrocnemius medialis, gastrocnemius lateralis, soleus) and normalised to the maximal activity measured during squat jump or isometric maximal voluntary contractions...
September 12, 2017: Sports Biomechanics
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