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Microrna and serum

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https://www.readbyqxmd.com/read/29691399/a-serum-microrna-signature-predicts-trastuzumab-benefit-in-her2-positive-metastatic-breast-cancer-patients
#1
Huiping Li, Jiang Liu, Jianing Chen, Huiyun Wang, Linbin Yang, Fei Chen, Siting Fan, Jing Wang, Bin Shao, Dong Yin, Musheng Zeng, Mengfeng Li, Jun Li, Fengxi Su, Qiang Liu, Herui Yao, Shicheng Su, Erwei Song
Trastuzumab is a standard treatment for HER2-positive (HER2+ ) breast cancer, but some patients are refractory to the therapy. MicroRNAs (miRNAs) have been used to predict therapeutic effects for various cancers, but whether miRNAs can serve as biomarkers for HER2+ metastatic breast cancer (MBC) patients remains unclear. Using miRNA microarray, we identify 13 differentially expressed miRNAs in the serum of HER2+ MBC patients with distinct response to trastuzumab, and four miRNAs are selected to construct a signature to predict survival using LASSO model...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29689557/microrna-125b-affects-vascular-smooth-muscle-cell-function-by-targeting-serum-response-factor
#2
Zhibo Chen, Mian Wang, Kai Huang, Qiong He, Honghao Li, Guangqi Chang
BACKGROUND/AIMS: Increasing evidence links microRNAs to the pathogenesis of peripheral vascular disease. We recently found microRNA-125b (miR-125b) to be one of the most significantly down‑regulated microRNAs in human arteries with arteriosclerosis obliterans (ASO) of the lower extremities. However, its function in the process of ASO remains unclear. This study aimed to investigate the expression, regulatory mechanisms, and functions of miR-125b in the process of ASO. METHODS: Using the tissue explants adherent method, vascular smooth muscle cells (VSMCs) were prepared for this study...
April 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29689553/microrna-374-exerts-protective-effects-by-inhibiting-sp1-through-activating-the-pi3k-akt-pathway-in-rat-models-of-myocardial-ischemia-reperfusion-after-sevoflurane-preconditioning
#3
Shu-Bo Zhang, Tie-Jun Liu, Guo-Hua Pu, Bao-Yong Li, Xiao-Zeng Gao, Xiao-Liang Han
BACKGROUND/AIMS: Ischemic heart disease is a leading cause of death in cardiovascular diseases, and microRNAs (miRs) have been reported to be potential therapeutic targets in heart disease. Herein, this study aims to investigate the effects of microRNA (miR)-374 on myocardial ischemia-reperfusion (I/R) injury in rat models pretreated with sevoflurane by targeting SP1 through the PI3K/Akt pathway. METHODS: SD rats were grouped into sham, I/R and sevoflurane + I/R (sevoflurane preconditioning and I/R) groups...
April 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29687864/the-molecular-mechanism-of-serum-microrna124b-induced-coronary-heart-disease-by-inducing-myocardial-cell-senescence
#4
M-L Guo, L-L Guo, Q-J Qin, Y-Q Weng, Y-N Wang, J Yao, Y-B Wang, X-Z Zhang, Z-M Ge
OBJECTIVE: The incidence and mortality of coronary heart disease are rapidly increasing in recent years. Myocardial cell dysfunction and cell senescence may play a role in coronary heart disease. MicroRNA controls a variety of biological processes, but leaving its role in coronary heart disease has yet to be explored. PATIENTS AND METHODS: Patients with coronary heart disease were regarded as subjects, and healthy volunteers as the control, on both of which microRNA124b level of serum was studied by Real-time PCR, and the heart function of patients was detected by using ultrasound...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29683761/circulating-micrornas-associated-with-prolonged-overall-survival-in-lung-cancer-patients-treated-with-nivolumab
#5
Ann Rita Halvorsen, Vandana Sandhu, Mette Sprauten, Vidar G Flote, Elin H Kure, Odd Terje Brustugun, Åslaug Helland
BACKGROUND: The introduction of immune check-point inhibition in non-small cell lung cancer (NSCLC) therapy represents improved prospects for the patients. The response rates to check-point inhibitors are approximately 20% in unselected NSCLC patients. Increasing levels of tumor PD-L1 expression are associated with higher response rates. However, patients with low PD-L1 levels may also have durable responses, and improved strategies for patient stratification are needed. MATERIAL AND METHODS: In this study, we investigated circulating microRNAs aiming to identify circulating predictive biomarkers associated with increased overall survival after immune check-point treatment...
April 23, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29683112/a-panel-of-serum-noncoding-rnas-for-the-diagnosis-and-monitoring-of-response-to-therapy-in-patients-with-breast-cancer
#6
Sheng-Kai Huang, Qing Luo, Hua Peng, Jia Li, Mei Zhao, Jia Wang, Yu-Yu Gu, Yan Li, Peng Yuan, Guo-Hua Zhao, Chang-Zhi Huang
BACKGROUND The aim of this study was to identify a panel of serum noncoding RNAs (ncRNAs) as potential diagnostic and prognostic biomarkers for breast cancer. MATERIAL AND METHODS Patients with breast cancer (n=30), and normal controls (n=30) were included in the 'training set.' A 'validation set' included cases of breast cancer (n=128) and controls (n=77). All cases provided blood samples for serum analysis. All cases of breast cancer were confirmed histologically and were staged. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to detect the expression of 11 candidate ncRNAs, including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), in the serum...
April 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29683066/identification-of-circulating-micrornas-as-diagnostic-biomarkers-for-ovarian-cancer-a-pooled-analysis-of-individual-studies
#7
Quan Zhou, Man-Zhen Zuo, Ze He, Hai-Rong Li, Wei Li
BACKGROUND: Circulating microRNAs (miRNAs) are proposed as promising non-invasive diagnostic biomarkers for many cancers. However, the diagnostic value of circulating miRNAs in ovarian cancer is inconsistent in different studies. Thus we performed this meta-analysis to systematically evaluate the diagnostic value of circulating miRNAs in ovarian cancer. METHODS: Eligible studies that were published prior to 30 June 2017 were searched from the PubMed, EMBASE, Cochrane Library, and Chinese National Knowledge Infrastructure...
April 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29682178/prognostic-value-of-circulating-micrornas-in-upper-tract-urinary-carcinoma
#8
Ruth Montalbo, Laura Izquierdo, Mercedes Ingelmo-Torres, Juan José Lozano, David Capitán, Antonio Alcaraz, Lourdes Mengual
The identification of upper tract urinary carcinoma (UTUC) prognostic biomarkers is urgently needed to predict tumour progression. This study aimed to identify serum microRNAs (miRNAs) that may be useful as minimally invasive predictive biomarkers of tumour progression and survival in UTUC patients. To this end, 33 UTUC patients who underwent radical nephroureterectomy at the Hospital Clinic of Barcelona were prospectively included. Expression of 800 miRNAs was evaluated in serum samples from these patients using nCounter® miRNA Expression Assays...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681887/circulating-microrna-profile-as-a-potential-predictive-biomarker-for-early-diagnosis-of-spontaneous-abortion-in-patients-with-subclinical-hypothyroidism
#9
Yingying Zhou, Xinyi Wang, Yuanyuan Zhang, Tong Zhao, Zhongyan Shan, Weiping Teng
An increasing number of studies suggest that subclinical hypothyroidism (SCH) is associated with complications of gestation, including spontaneous abortion (SA). However, the underlying mechanism is not clear. MicroRNA (miRNA) has been demonstrated to be closely related to gynecological reproductive diseases. We determined miRNA expression in patients with SCH, SCH with SA (SCH + SA), and in those with SA as well as healthy controls (HCs), and analyzed whether dysregulation in several miRNAs was specific to these cohorts...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29680855/mir-1226-detection-in-gcf-as-potential-biomarker-of-chronic-periodontitis-a-pilot-study
#10
P Mico-Martinez, J-L Garcia-Gimenez, M Seco-Cervera, A Lopez-Roldan, P-J Alminana-Pastor, F Alpiste-Illueca, F-V Pallardo
BACKGROUND: The study and identification of new biomarkers for periodontal disease, such as microRNAs (miRNAs), may give us more information about the location and severity of the disease and will serve as a basis for treatment planning and disease-monitoring. miRNAs are a group of small RNAs which are involved in gene regulation by binding to their messenger RNA target (mRNA). In this pilot study, the procedure for purifying miRNAs from gingival crevicular fluid (GCF) was, for the first time, described...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29677902/re-microrna-mir-371a-3p-a-novel-serum-biomarker-of-testicular-germ-cell-tumors-evidence-for-specificity-from-measurements-in-testicular-vein-blood-and-in-neoplastic-hydrocele-fluid
#11
https://www.readbyqxmd.com/read/29674977/serum-derived-extracellular-vesicles-protect-against-acute-myocardial-infarction-by-regulating-mir-21-pdcd4-signaling-pathway
#12
Huanyu Gu, Zhuyuan Liu, Yongqin Li, Yuan Xie, Jianhua Yao, Yujiao Zhu, Jiahong Xu, Qiying Dai, Chongjun Zhong, Hao Zhu, Shengguang Ding, Lei Zhou
Acute myocardial infarction (AMI) represents a leading cause of morbidity and mortality worldwide. Extracellular vesicles (EVs) are being recognized as a promising therapeutic approach in protecting against MI. Serum is a rich source of EVs, which transports various microRNAs (miRNAs, miRs). EVs from serum have been shown beneficial for protecting against ischemia-reperfusion injury; however, their roles in AMI are unclear. In addition, whether a miRNA might be responsible for the effects of serum EVs on protecting against AMI is undetermined...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29674765/clinical-and-functional-significance-of-intracellular-and-extracellular-microrna-25-3p-in-osteosarcoma
#13
Aki Yoshida, Tomohiro Fujiwara, Koji Uotani, Takuya Morita, Masahiro Kiyono, Suguru Yokoo, Joe Hasei, Eiji Nakata, Toshiyuki Kunisada, Toshifumi Ozaki
Although there is considerable evidence indicating that the dysregulation of microRNAs (miRNAs) in malignant tumors plays a role in tumor development, the overall function of miRNAs and their clinicopathological significance are not well understood. In this retrospective analysis of 45 biopsy specimens from osteosarcoma (OS) patients, we investigated the functional and clinical significance of miR-25-3p in OS, which we previously identified as a highly expressed miRNA in OS patients' serum. We observed that miR-25-3p dysregulation in human OS tissues was negatively correlated with the clinical prognosis, whereas the expression level of its target gene, Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3), was positively correlated with the clinical prognosis...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29673400/long-noncoding-rna-h19-upregulates-vascular-endothelial-growth-factor-a-to-enhance-mesenchymal-stem-cells-survival-and-angiogenic-capacity-by-inhibiting-mir-199a-5p
#14
Jingying Hou, Lingyun Wang, Quanhua Wu, Guanghui Zheng, Huibao Long, Hao Wu, Changqing Zhou, Tianzhu Guo, Tingting Zhong, Lei Wang, Xuxiang Chen, Tong Wang
BACKGROUND: Currently, the overall therapeutic efficiency of mesenchymal stem cells (MSCs) transplantation for the treatment of cardiovascular disease is not satisfactory. The low viability and angiogenic capacity of the implanted cells in the local infarct tissues restrict their further application. Evidence shows that long noncoding RNA H19 (lncRNA-H19) mediates cell survival and angiogenesis. Additionally, it is also involved in MSCs biological activities. This study aimed to explore the functional role of lncRNA-H19 in MSCs survival and angiogenic capacity as well as the underlying mechanism...
April 19, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29672637/optimisation-of-quantitative-mirna-panels-to-consolidate-the-diagnostic-surveillance-of-hbv-related-hepatocellular-carcinoma
#15
Ngo Tat Trung, Dang Chieu Duong, Hoang Van Tong, Tran Thi Thu Hien, Phan Quoc Hoan, Mai Hong Bang, Mai Thanh Binh, Thai Doan Ky, Nguyen Lam Tung, Nguyen Tien Thinh, Vu Viet Sang, Le Thi Phuong Thao, C-Thomas Bock, Thirumalaisamy P Velavan, Christian G Meyer, Le Huu Song, Nguyen Linh Toan
BACKGROUND: Circulating microRNAs (miRNA) are biomarkers for several neoplastic diseases, including hepatocellular carcinoma (HCC). We performed a literature search, followed by experimental screening and validation in order to establish a miRNA panel in combination with the assessment of alpha-fetoprotein (AFP) levels and to evaluate its performance in HCC diagnostics. METHODS: Expression of miRNAs was quantified by quantitative PCR (qPCR) in 406 serum samples from 118 Vietnamese patients with hepatitis B (HBV)-related HCC, 69 patients with HBV-related liver cirrhosis (LC), 100 chronic hepatitis B (CHB) patients and 119 healthy controls (HC)...
2018: PloS One
https://www.readbyqxmd.com/read/29671027/comparison-of-commercial-exosome-isolation-kits-for-circulating-exosomal-microrna-profiling
#16
Meng Ding, Cheng Wang, Xiaolan Lu, Cuiping Zhang, Zhen Zhou, Xi Chen, Chen-Yu Zhang, Ke Zen, Chunni Zhang
Circulating exosomal microRNAs (miRNAs) are valuable biomarker candidates; however, information on the characterization and mutual agreement of commercial kits for circulating exosomal miRNA profiling is scarce. Here, we analyzed the advantages and weaknesses of four commonly used commercial kits for exosomal miRNA profiling and their application to the sample of serum and/or plasma, respectively. NanoSight and Western blotting were conducted to evaluate the efficiency and purity of the isolated exosomes. In our conditions, the size distribution of the isolated particles was appropriate (40-150 nm), and ExoQuick™ Exosome Precipitation Solution (EXQ) generated a relatively high yield of exosomes...
April 18, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29670247/effects-of-microrna-292-5p-on-myocardial-ischemia-reperfusion-injury-through-the-peroxisome-proliferator-activated-receptor-%C3%AE-%C3%AE-signaling-pathway
#17
Zhen-Dong Zhu, Ji-Yun Ye, Hua Niu, Yu-Mei Ma, Xue-Mei Fu, Zhong-Hua Xia, Xuan Zhang
Ischemia-reperfusion injury (IRI) is a major cause of cardiac damage following various pathological processes, such as free radical damage and cell apoptosis. This study aims to investigate whether microRNA-292-5p (miR-292-5p) protects against myocardial ischemia-reperfusion injury (IRI) via the peroxisome proliferator-activated receptor (PPAR)-α/-γ signaling pathway in myocardial IRI mice models. Mouse models of myocardial IRI were established. Adult male C57BL/6 mice were divided into different groups. The hemodynamic indexes, levels of related inflammatory factors and serum myocardial enzymes, and malondialdehyde (MDA) content and the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were detected...
April 18, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29669324/clinical-significance-of-mir-210-and-its-prospective-signaling-pathways-in-non-small-cell-lung-cancer-evidence-from-gene-expression-omnibus-and-the-cancer-genome-atlas-data-mining-with-2763-samples-and-validation-via-real-time-quantitative-pcr
#18
Rong-Quan He, Wei-Luan Cen, Jie-Mei Cen, Wei-Ning Cen, Jia-Yi Li, Mei-Wei Li, Ting-Qing Gan, Xiao-Hua Hu, Gang Chen
BACKGROUND/AIMS: Since the function of microRNA (miR)-210 in non-small cell lung cancer (NSCLC) remains unclear, we aimed to explore the clinical significance of miR-210 in NSCLC. METHODS: NSCLC-related data from 1673 samples on Gene Expression Omnibus and 1090 samples on The Cancer Genome Atlas were obtained and analyzed. The expression level of miR-210 was validated via real-time quantitative PCR analysis with 125 paired clinical samples. A meta-analysis was performed to generate a comprehensive understanding of miR-210 expression and its clinical significance in NSCLC...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29668922/circulating-and-fecal-micrornas-as-biomarkers-for-inflammatory-bowel-diseases
#19
Katharina Schönauen, Nha Le, Ulrike von Arnim, Christian Schulz, Peter Malfertheiner, Alexander Link
Background: Assessment of the disease activity in inflammatory bowel disease (IBD) is essential for adequate treatment management and reliable noninvasive biomarkers for verification of mucosal healing are still needed. MicroRNAs (miRNAs) are differentially expressed in IBD and cancer. We aimed to evaluate the potential of circulating and fecal miRNAs as diagnostic biomarkers for IBD. Methods: In this proof-of-principle study we used 2 independent patient cohorts...
April 12, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29663998/-microrna-34a-participates-in-lipopolysaccharide-mediated-sepsis-related-renal-function-impairment-via-kruppel-like-factor-4
#20
Qidong Jiang, Changxue Wu, Qiong Zhang
OBJECTIVE: To investigate whether microRNA-34a (miR-34a) participates in lipopolysaccharide (LPS) mediated sepsis related renal function impairment via Kruppel-like factor 4 (KLF4). METHODS: Thirty healthy male Sprague-Dawley (SD) rats, weighing 180-200 g, were randomly divided into two groups: control group and model group, with 15 rats in each group. The SD rats from model group were injected with LPS 7.5 mg/kg to induce sepsis related renal function impairment model, the SD rats from control group were injected with normal saline...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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