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Microrna and serum

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https://www.readbyqxmd.com/read/29457379/levels-of-cytokines-and-micrornas-in-individuals-with-asymptomatic-hyperuricemia-and-ultrasonographic-findings-of-gout-a-bench-to-bedside-approach
#1
Irving O Estevez-Garcia, Selma Gallegos-Nava, Erika Vera-Pérez, Luis H Silveira, Lucio Ventura-Ríos, Gonzalo Vancini, Cristina Hernández-Díaz, Fausto Sánchez-Muñoz, Martha A Ballinas-Verdugo, Marwin Gutierrez, Carlos Pineda, Pedro Rodriguez-Henriquez, Diana Castillo-Martínez, Luis M Amezcua-Guerra
OBJECTIVE: To assess potential associations among serum cytokines and microRNA (miR) levels with ultrasound (US) findings suggestive of urate deposits in chronic asymptomatic hyperuricemia and gout. METHODS: All participants underwent musculoskeletal US and measurements of serum IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IFN-γ, TNF, MCP-1, and ENA-78, as well as miR-146a, miR-155, and miR-223 levels. RESULTS: Thirty individuals with asymptomatic hyperuricemia, 31 normouricemic controls, and 30 gouty patients were included...
February 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29456723/mir-96-promotes-breast-cancer-metastasis-by-suppressing-mtss1
#2
Wei Xie, Feng Sun, Lin Chen, Xinjian Cao
Novel, non-invasive biomarkers with high sensitivity and specificity are critical for breast cancer treatment, and prognosis. MicroRNA (miR)-96 has been demonstrated to be highly expressed in several solid malignancies, including breast cancer. However, its expression and function in the metastasis and prognosis of breast cancer have not been fully explored, and its regulation mechanisms remain unclear. In the present study, the serum miR-96 expression in healthy controls, benign and malignant breast cancer types was compared by using reverse transcription-quantitative polymerase chain reaction...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29455432/serum-mirna-27a-and-mirna-18b-as-potential-predictive-biomarkers-of-hepatitis-c-virus-associated-hepatocellular-carcinoma
#3
Nearmeen M Rashad, Amal S El-Shal, Sally M Shalaby, Salem Y Mohamed
Hepatitis C virus (HCV) infection remains the main risk factor for chronic hepatitis (CHC), liver cirrhosis, and hepatocellular carcinoma (HCC). Changes in microRNA (miRNA) profiles can be associated with HCV infection and may either favor or inhibit the virus and/or its complication. Moreover, miRNAs have emerged as key regulators of various cancers including HCC. The aim of this work was to investigate the potentail role of miRNA-27a and miRNA-18b expression levels as non-invasive predictive biomarkers of hepatitis C virus-associated HCC...
February 17, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29453920/effect-of-trans-chalcone-on-hepatic-il-8-through-the-regulation-of-mir-451-in-male-rats
#4
Elham Karimi-Sales, Sajad Jeddi, Arshad Ghaffari-Nasab, Mina Salimi, Mohammad Reza Alipour
OBJECTIVE: Trans-chalcone is a chalcone with hepatoprotective and anti-inflammatory effects. However, the mechanism of these positive effects, especially on miR-451 as an inflammatory regulator, is poorly understood. In this regard, this microRNA (miRNA) acts by inhibition of hepatic interleukin-8 (IL-8) production in the liver which is one of the main proinflammatory cytokines. Th is study for the first time examined the effect of trans-chalcone on miR-451/IL-8 pathway. METHODS: In present study, 21 male rats were randomly divided into 3 groups (n=7 per each group): control which received solvent (NS), groups 2 (N2T) and 3 (N6T), which received transchalcone for 2 and 6 weeks, respectively...
January 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29453719/microrna-411-promoted-the-osteosarcoma-progression-by-suppressing-mtss1-expression
#5
Zhange Yu, Ning Xu, Weiliang Yang, Yang Liu, Feng Yan
MicroRNAs (miRNAs) play crucial roles in the progression of different tumors. In our study, we investigated the expression and roles of miR-411 in human osteosarcoma. In this study, we first confirmed that the miR-411 expression was higher in the serum of patients with osteosarcoma than in the serum of healthy volunteers. In addition, we found that the miR-411 expression was upregulated in the osteosarcoma tissues compared to that in the matched normal bone tissues. We also demonstrated that the miR-411 expression was upregulated in the four osteosarcoma cell lines...
February 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29453660/verification-of-candidate-microrna-markers-for-parathyroid-carcinoma
#6
Ya Hu, Xiang Zhang, Ming Cui, Zhe Su, Mengyi Wang, Quan Liao, Yupei Zhao
PURPOSE: Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of miRNA markers in a new series of samples to explore their potential significance in PCa diagnosis. METHODS: A total of 58 tissue samples, including 17 PCa lesions and 41 sporadic parathyroid adenomas (PAds), were obtained from 56 primary hyperparathyroidism (pHPT) patients...
February 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29445851/beta-cell-extracellular-vesicle-mir-21-5p-cargo-is-increased-in-response-to-inflammatory-cytokines-and-serves-as-a-biomarker-of-type-1-diabetes
#7
Alexander J Lakhter, Rachel E Pratt, Rachel E Moore, Kaitlin K Doucette, Bernhard F Maier, Linda A DiMeglio, Emily K Sims
AIMS/HYPOTHESIS: Improved biomarkers are acutely needed for the detection of developing type 1 diabetes, prior to critical loss of beta cell mass. We previously demonstrated that elevated beta cell microRNA 21-5p (miR-21-5p) in rodent and human models of type 1 diabetes increased beta cell apoptosis. We hypothesised that the inflammatory milieu of developing diabetes may also increase miR-21-5p in beta cell extracellular vesicle (EV) cargo and that circulating EV miR-21-5p would be increased during type 1 diabetes development...
February 14, 2018: Diabetologia
https://www.readbyqxmd.com/read/29439651/serum-and-blood-based-biomarkers-for-lung-cancer-screening-a-systematic-review
#8
Gavin C W Chu, Kim Lazare, Frank Sullivan
BACKGROUND: Lung cancer is the second most common cancer and the leading cause of cancer death for both men and women. Although low-dose CT (LDCT) is recommended for lung cancer screening in high-risk populations and may decrease lung cancer mortality, there is a need to improve the accuracy of lung cancer screening to decrease over-diagnosis and morbidity. Blood and serum-based biomarkers, including EarlyCDT-lung and microRNA based biomarkers, are promising adjuncts to LDCT in lung cancer screening...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29439315/downregulated-mir-217%C3%A2-expression-predicts-a-poor-outcome-in-acute%C3%A2-myeloid-leukemia
#9
Jinhua Yan, Guohe Wu, Jianlan Chen, Lifang Xiong, Guoan Chen, Ping Li
BACKGROUND: Circulating microRNAs (miRNAs) play an essential role in the development and progression of acute myeloid leukemia (AML). However, the clinical value of serum miR-217 in AML remained poorly known. OBJECTIVE: This study aimed to explore the clinical significance of serum miR-217 in AML. METHODS: Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was performed to detect miR-217 levels in the blood samples obtained from 89 AML patients and 60 healthy controls...
January 29, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29437039/microrna-1246-is-an-exosomal-biomarker-for-aggressive-prostate-cancer
#10
Divya Bhagirath, Thao Ly Yang, Nathan Bucay, Kirandeep Sekhon, Shahana Majid, Varahram Shahryari, Rajvir Dahiya, Yuichiro Tanaka, Sharanjot Saini
Due to high heterogeneity, molecular characterization of prostate cancer (PCa) based on biopsy sampling is often challenging. Hence, a minimally invasive method to determine the molecular imprints of a patient's tumor for risk stratification would be advantageous. In this study, we employ a novel, digital amplification-free quantification method using the nCounter technology (Nanostring Technologies) to profile exosomal serum miRNAs (ex-miRNA) from aggressive PCa cases, benign prostatic hyperplasia (BPH), and disease-free controls...
February 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/29435115/fibrosis-related-mirnas-as-serum-biomarkers-for-pancreatic-ductal-adenocarcinoma
#11
Rei Suzuki, Hiroyuki Asama, Yuichi Waragai, Tadayuki Takagi, Takuto Hikichi, Mitsuru Sugimoto, Naoki Konno, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Yuki Sato, Shigeru Marubashi, Atsushi Masamune, Hiromasa Ohira
We investigated whether serum microRNAs (miRNAs) could be diagnostic or prognostic markers in pancreatic ductal adenocarcinoma (PDAC). We first identified miRNAs showing altered expression in human pancreatic stellate cells (hPSCs) co-cultured with PDAC cells (Panc-1 and BxPC-3) as compared to hPSCs cultured alone. Among the miRNAs with altered expression, let-7d exhibited reduced expression in an in silico analysis of The Cancer Genome Atlas data. Inhibition of let-7d resulted in enhanced expression of fibrosis-related genes...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435069/serum-microrna-193b-as-a-promising-biomarker-for-prediction-of-chemoradiation-sensitivity-in-esophageal-squamous-cell-carcinoma-patients
#12
Chung Man Chan, Kenneth K Y Lai, Enders K O Ng, Mei Na Kiang, Tiffany W H Kwok, Hector K Wang, Kwok Wah Chan, Tsz Ting Law, Daniel K Tong, Kin Tak Chan, Nikki P Lee, Simon Law
Esophageal squamous cell carcinoma (ESCC) is the most predominantly occurring type of esophageal cancer worldwide. Locally advanced ESCC patients are treated by neoadjuvant chemoradiation for tumor downstaging prior to tumor resection. Patients receiving this treatment have an increased expectation of cure via the following tumor resection and have better survival outcomes. However, not all patients respond well to chemoradiation and poor responders suffer from treatment-associated toxicity and complications without benefits...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434773/human-adipose-derived-mesenchymal-stem-cell-conditioned-media-suppresses-inflammatory-bone-loss-in-a-lipopolysaccharide-induced-murine-model
#13
Yu Li, Xin Gao, Jinbing Wang
Conditioned media (CM) from mesenchymal stem cells (MSCs) contains various cytokines, growth factors and microRNAs, which may serve important roles in modulating the inflammatory process. However, the effect of MSC-CM on inflammatory bone loss remains unknown. The present study investigated the effects of conditioned media from human adipose-derived mesenchymal stem cells (AMSC-CM) on the prevention of lipopolysaccharide (LPS)-mediated bone loss in mice. To investigate the underlying mechanisms of this effect, the effects of AMSC-CM on serum levels of inflammation-associated cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6 and IL-10] in LPS-treated mice, in addition to their mRNA expression in LPS-treated macrophages, was investigated...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434712/function-and-mechanism-of-microrna-210-in-acute-cerebral-infarction
#14
Jun Wang, Yuezhan Zhang, Feng Xu
Acute cerebral infarction (ACI) is a common cerebrovascular disease. Previous studies have indicated that microRNAs (miRs) are aberrantly expressed in patients with ACI. However, the functions of miRs in the pathogenesis of ACI still require further investigation. The aim of the present study was to investigate the function of miR-210 in ACI and its associated mechanism. The expression of miR-210 in the serum of 40 patients with ACI and 40 normal controls was examined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434260/circulating-exosomal-micrornas-reveal-the-mechanism-of-fructus-meliae-toosendan-induced-liver-injury-in-mice
#15
Jie Zheng, Lingqi Yu, Wen Chen, Xiaoyan Lu, Xiaohui Fan
The toxicological mechanisms of liver injury caused by most traditional Chinese medicine (TCM) remain largely unknown. Due to the unique features, exosomal microRNAs (miRNAs) are currently attracting major interests to provide further insights into toxicological mechanisms. Thus, taking Fructus Meliae Toosendan as an example of hepatoxic TCM, this study aimed to elucidate its hepatotoxicity mechanisms through profiling miRNAs in circulating exosomes of Fructus Meliae Toosendan water extract (FMT)-exposed mice...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29431644/induction-of-microrna-199-by-nitric-oxide-in-endothelial-cells-is-required-for-nitrovasodilator-resistance-via-targeting-of-prostaglandin-i2-synthase
#16
Yong-Ping Bai, Jia-Xiong Zhang, Quan Sun, Ji-Peng Zhou, Jing-Min Luo, Ling-Fang He, Xing-Chi Lin, Ling-Ping Zhu, Wan-Zhou Wu, Zhen-Yu Wang, Guo-Gang Zhang
Background -Nitrates are widely used to treat coronary artery disease, but their therapeutic value is compromised by nitrate tolerance, owing to the dysfunction of prostaglandin I2 synthase (PTGIS). Micro RNAs (miRNAs) repress target gene expression and are recognized as important epigenetic regulators of endothelial function. The aim of this study was to determine whether nitrates induce nitrovasodilator resistance via microRNA-dependent repression of PTGIS gene expression. Methods -Nitrovasodilator resistance was induced by nitroglycerin (GTN; 100 mg/kg/day, 3 days) infusion in Apoe-/- mice...
February 5, 2018: Circulation
https://www.readbyqxmd.com/read/29430184/application-of-serum-microrna-9-5p-21-5p-and-223-3p-combined-with-tumor-markers-in-the-diagnosis-of-non-small-cell-lung-cancer-in-yunnan-in-southwestern-china
#17
Yanlong Yang, Kai Chen, Yongchun Zhou, Zaoxiu Hu, Shuai Chen, Yunchao Huang
Purpose: Xuanwei City is located in late Permian coal-accumulating areas of the northeastern region of Yunnan Province. In China, morbidity and mortality from lung cancer are highest in Yunnan. Identifying useful circulating markers suitable for the diagnosis of lung cancer in this region is quite meaningful. In this study, we evaluated diagnostic roles of serum miR-9-5p, 21-5p, 223-3p, 135b-5p, 339-5p, and 501-5p in patients with non-small-cell lung cancer (NSCLC) in Yunnan. Moreover, we evaluated the diagnostic performance of several tumor markers, including carcinoembryonic antigen (CEA), cytokeratin 19 fragment 21-1 (CYFRA21-1), and squamous cell carcinoma-related antigen (SCC)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29424904/mir-212-3p-reduced-proliferation-and-promoted-apoptosis-of-fibroblast-like-synoviocytes-via-down-regulating-sox5-in-rheumatoid-arthritis
#18
Y Liu, X-L Zhang, X-F Li, Y-C Tang, X Zhao
OBJECTIVE: Several microRNAs have been reported to contribute the progression of rheumatoid arthritis (RA) due to the ectopic expression of miRNAs in fibroblast-like synoviocytes (FLS). However, the function of miR-212-3p in RA still has not been mentioned before. PATIENTS AND METHODS: We obtained serum, synovial tissues, and FLS samples from RA patients and normal donors. Quantitative Real-time polymerase chain reaction (qRT-PCR) was used to analysis the expression level of miR-212-3p...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29419680/mir-664a-3p-expression-in-patients-with-obstructive-sleep-apnea-a-potential-marker-of-atherosclerosis
#19
Kun Li, Zhiting Chen, Yanwen Qin, Yongxiang Wei
The early prediction of atherosclerosis (AS) is important in the management of obstructive sleep apnea patients (OSA). MicroRNA (miRNA) plays a vital role in the evolution of OSA and AS. Its differential expression may therefore serve as a diagnostic and prognostic biomarker of AS in OSA. The aim of this study was to identify specific serum miRNAs that could serve as a novel screening signature of AS in OSA patients. The specificity and sensitivity of these miRNAs in the early diagnosis of AS in OSA patients were then determined...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29416771/menopause-and-adipose-tissue-mir-19a-3p-is-sensitive-to-hormonal-replacement
#20
Reeta Kangas, Cristina Morsiani, Grazia Pizza, Catia Lanzarini, Pauliina Aukee, Jaakko Kaprio, Sarianna Sipilä, Claudio Franceschi, Vuokko Kovanen, Eija K Laakkonen, Miriam Capri
Tissue-specific effects of 17β-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat distribution in women. This investigation aimed at identifying menopause- and hormone replacement therapy (HRT)-associated miR profiles and miR targets in subcutaneous abdominal adipose tissue and serum from the same women. A discovery phase using array technology was performed in 13 women, including monozygotic twin pairs discordant for HRT and premenopausal young controls...
January 5, 2018: Oncotarget
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