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https://www.readbyqxmd.com/read/29933075/toxicology-study-for-magnetic-injection-of-prednisolone-into-the-rat-cochlea
#1
M Shimoji, B Ramaswamy, M I Shukoor, P Benhal, A Broda, S Kulkarni, P Malik, B McCaffrey, J-F Lafond, A Nacev, I N Weinberg, B Shapiro, D A Depireux
This paper investigates the safety of a novel 'magnetic injection' method of delivering therapy to the cochlea, in a rodent model. In this method of administration, a magnetic field is employed to actively transport drug-eluting iron oxide-core nanoparticles into the cochlea, where they then release their drug payload (we delivered the steroid prednisolone). Our study design and selection of control groups was based on published regulatory guidance for safety studies that involve local drug delivery. We tested for both single and multiple delivery doses to the cochlea, and found that magnetic delivery did not harm hearing...
June 19, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29928088/unclassified-congenital-deformities-of-the-external-ear
#2
Madhubari Vathulya
Congenital ear deformities are a common entity. They are found in isolation or as a part of syndrome in patients. They may involve the external, middle or inner ear or in any of these combinations. Three patients of different ages presented with deformities including mirror image duplication of the superior auricle, unclassified deformities of ear lobule (wavy lobule) and deformity of superior auricle with unclassified variety of lateral ear pit. This article highlights that there are further cases of ear deformities that are noticed in the general population who come for cosmetic correction, and hence, there is a need for further modifying the classification of ear deformities...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29922125/key-genes-and-pathways-associated-with-inner-ear-malformation-in-sox10-p-r109w-mutation-pigs
#3
Qing-Qing Hao, Liang Li, Wei Chen, Qing-Qing Jiang, Fei Ji, Wei Sun, Hong Wei, Wei-Wei Guo, Shi-Ming Yang
SRY-box 10 (SOX10) mutation may lead to inner ear deformities. However, its molecular mechanisms on inner ear development are not clear. In this work, the inner ear morphology was investigated at different embryonic stages of the SOX10 mutation miniature porcine model with sensorineural hearing loss, and high-throughput RNA-seq and bioinformatics analyses were applied. Our results indicated that the SOX10 mutation in the miniature pigs led to an incomplete partition (IP) of the cochlea, a cystic apex caused by fusion from middle and apical turns, cochlear modiolar defects and a shortened cochlear duct...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29921359/aviation-fuel-exposure-resulting-in-otitis-externa-with-vertigo
#4
Robert J Long, Reese A Charles
BACKGROUND: Otitis externa secondary to irritant or chemical exposure is well documented; however, specifically secondary to jet fuel exposure and its associated toxicology is not. Over 2 million military and civilian personnel per year are occupationally exposed to aviation fuels. CASE REPORT: An aircraft maintainer presented with noninfectious acute otitis externa secondary to external ear canal exposure to JP-5 jet fuel. Proper exposure guidelines were followed, but it was not realized that the external ear canal was involved...
July 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29921050/-clinical-features-of-recurrences-in-benign-paroxysmal-positional-vertigo
#5
X X Li, Y K Ou, X W Tang, L Chen, P Liu, Q H Huang, Y Q Zheng
Objective: To study the clinical features of patients with recurrent benign paroxysmal positional vertigo (BPPV) and to analyze potential related factors of recurrences. Method: Eighty patients who suffered recurrent BPPV were enrolled in this study. Patients were divided into three groups: young group (21 cases), middle-aged group (25 cases) and old-aged group (34 cases). Theclinical data including age, gender, pathological pattern and canal type of BPPV were collected. We further analyzed the efficacy of repositioning treatment for recurrent BPPV...
June 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29916767/development-of-an-ear-cap-in-chronic-suppurative-otitis-media-using-additive-manufacturing-and-triz
#6
Mahesh B Mawale, Abhaykumar Kuthe, Anupama M Mawale, Sandeep W Dahake
The prevalence rate of chronic suppurative otitis media is high and its treatment continues to be a challenge for the otorhinolaryngologists. Due to middle ear infection, there may be pain, hearing loss and spontaneous rupture of the eardrum which results in perforation. Infections can cause a hole in the eardrum as a side effect of otitis media. The patients suffering from ear perforation or having a hole in eardrum require preventing entry of water in the ear. This article describes the development of ear cap using additive manufacturing and TRIZ (a collaborative tool) to prevent the entry of water in the ear during chronic otitis media...
June 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29915938/-state-of-the-art-of-quality-of-life-measurement-in-patients-with-chronic-otitis-media-and-conductive-hearing-loss
#7
REVIEW
S Lailach, I Baumann, T Zahnert, M Neudert
The evaluation of results after middle ear reconstruction has been mainly based on functional parameters. In clinical practice as well as in otological research, the pure tone audiogram represents the gold standard in the assessment of the postoperative outcome. In order to assess the patient's subjective outcome, outcome analyzes focus increasingly on the health-related quality of life (HRQOL). However, the evaluation of HRQOL requires reliable and validated measuring instruments. A modest number of validated questionnaires for determination of the disease-specific HRQOL in patients with chronic otitis media and/or conductive hearing loss are currently available...
June 18, 2018: HNO
https://www.readbyqxmd.com/read/29915406/characterization-of-mucoid-and-serous-middle-ear-effusions-from-patients-with-chronic-otitis-media-implication-of-different-biological-mechanisms
#8
Stéphanie Val, Marian Poley, Krueger Anna, Gustavo Nino, Kristy Brown, Marcos Pérez-Losada, Heather Gordish-Dressman, Diego Preciado
BACKGROUND: Chronic otitis media with effusion (COME) is characterized by persistent middle ear effusions that are in most cases highly viscous, but some patients present with serous fluid. This study aimed at comprehensively characterizing the macromolecular composition of mucoid vs. serous middle ear effusions (MEEs). METHODS: MEEs from patients with COME were analyzed for proteins by mass spectrometry (MS) and western blot techniques, total DNA quantity, bacterial DNA (16S sequencing), and cytokine content...
May 28, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29912830/intracochlear-pressures-in-simulated-otitis-media-with-effusion-a-temporal-bone-study
#9
Mohamed A Alhussaini, Renee M Banakis Hartl, Victor Benichoux, Daniel J Tollin, Herman A Jenkins, Nathaniel T Greene
HYPOTHESIS: Simulated otitis media with effusion reduces intracochlear pressures comparable to umbo velocity. BACKGROUND: Otitis media with effusion is a common cause of temporary hearing loss, particularly in children, producing deficits of 30 to 40 dB. Previous studies measured the effects of simulated effusion on ossicular mechanics; however, no studies have measured cochlear stimulation directly. Here, we compare pressures in the scala vestibuli and tympani to umbo velocity, before and after induction of simulated effusion in cadaveric human specimens...
June 15, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29912826/comparison-of-postoperative-pain-in-patients-following-transcanal-endoscopic-versus-microscopic-ear-surgery
#10
Seiji Kakehata, Takatoshi Furukawa, Tsukasa Ito, Toshinori Kubota, Kazunori Futai, Tomoo Watanabe
OBJECTIVE: To compare levels and causes of postoperative pain after cholesteatoma removal by transcanal endoscopic ear surgery (TEES) versus microscopic ear surgery (MES). STUDY DESIGN: Prospective case series. SETTING: Tertiary referral center. PATIENTS: One-hundred-and-sixty-one patients who had undergone middle ear surgery between February 2013 and April 2016. INTERVENTIONS: Comparison of postoperative pain between TEES and MES groups and among TEES and MES subgroups divided by range of bone removal...
June 15, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29912645/use-of-a-modified-bubble-continuous-positive-airway-pressure-bcpap-device-for-children-in-respiratory-distress-in-low-and-middle-income-countries-a-safety-study
#11
Ashley R Bjorklund, Beatrice Odongkara Mpora, Marie E Steiner, Gwenyth Fischer, Cynthia S Davey, Tina M Slusher
BACKGROUND: While bubble continuous positive airway pressure (bCPAP) is commonly used in low- and middle-income countries (LMIC) to support neonates with respiratory distress, there are limited non-invasive support options for non-neonatal children. AIM: To demonstrate safety of a new device designed to support children during respiratory distress in LMIC. METHODS: A paediatric bCPAP device was designed called SEAL-bCPAP (Simplified Ear-plug Adapted-bCPAP)...
June 18, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29909612/clinical-characteristics-of-temporal-bone-metastases
#12
Kunho Song, Ki-Wan Park, Jae-Hyung Heo, Ik-Chan Song, Yong-Ho Park, Jin Woong Choi
Objectives: The purposes of this study were to evaluate the clinical characteristics of temporal bone metastasis (TBM) and to determine whether the characteristics differed according to primary malignancy. Methods: We retrospectively analyzed data on 20 patients diagnosed with TBM between January 2000 and January 2017. Demographics, the period from diagnosis of primary malignancy to TBM diagnosis, the period from TBM diagnosis to death, the type and staging of primary malignancy, otologic manifestations, and TBM sites were assessed...
June 19, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29909018/successful-treatment-of-eosinophilic-otitis-media-associated-with-severe-bronchial-asthma-with-an-anti-il-5-monoclonal-antibody-mepolizumab
#13
Isao Suzaki, Yurika Kimura, Akihiko Tanaka, Kojiro Hirano, Atsushi Ishibashi, Tomomi Mizuyoshi, Izumi Ando, Tatsuya Kitajima, So Watanabe, Yasuyuki Hinonira, Hitome Kobayashi
Eosinophilic otitis media (EOM), which is characterized by the accumulation of eosinophils in middle ear effusion and the middle ear mucosa, is a refractory type of otitis media that is often associated with asthma. Although an early diagnosis and appropriate treatment are necessary to prevent the progression of hearing loss in patients with EOM, there are currently no well-established treatments for this condition. We treated a 60-year-old male patient with asthma and EOM. The patient's asthma was poorly controlled, despite the use of high-dose inhaled corticosteroids, long-acting beta-agonist treatment, and the regular use of systemic corticosteroids...
June 13, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29908720/incidence-of-intraoperative-hearing-loss-during-middle-cranial-fossa-approach-for-repair-of-superior-semicircular-canal-dehiscence
#14
Michael Johanis, Isaac Yang, Quinton Gopen
INTRODUCTION: Superior semicircular canal dehiscence is a rare inner ear disorder characterized by an abnormal third opening between the superior semicircular canal and middle fossa. Symptoms include amplification of internal sounds, aural fullness, tinnitus, hearing loss, autophony, sound-induced vertigo (Tullio phenomenon), pressure-induced vertigo (Hennebert sign), disequilibrium, nystagmus, oscillopsia, and headache. While no cure exists for SSCD, surgical treatment has proven to effectively minimize these symptoms...
June 13, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29902786/the-impact-of-two-stage-subtotal-petrosectomy-and-round-window-vibroplasty-on-bone-conduction-thresholds
#15
Nils Kristian Prenzler, Lennart Gruber, Thomas Lenarz, Hannes Maier, Burkard Schwab
OBJECTIVE: To evaluate possible increases in bone conduction (BC) hearing thresholds in patients undergoing subtotal petrosectomy (SP) with fat obliteration and blind sac closure of the outer ear canal and subsequent round window vibroplasty. PATIENTS AND INTERVENTIONS: Between 1997 and 2013, 43 patients (45 ears) with combined hearing loss and recurrent chronic otitis or status post formation of a radical cavity underwent SP around 6 months prior to implantation of a Vibrant SoundbridgeTM...
June 14, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29891397/immediate-effects-of-a-rhino-pharyngeal-clearance-protocol-in-nasal-obstruction-and-middle-ear-condition-of-children-under-3-years-of-age-with-upper-respiratory-infections-a-randomized-controlled-trial
#16
Ana Silva Alexandrino, Rita Santos, Cristina Melo, David Tomé, José Mesquita Bastos, Guy Postiaux
INTRODUCTION AND OBJECTIVES: Children up to 2 years old are at high risk of respiratory infections and nasal irrigation is often prescribed. Yet, to date there is no sufficient knowledge about its immediate effects on the nasopharynx and middle ear. Therefore, this study aimed to analyze the effect of a rhino-pharyngeal clearance intervention protocol on nasal obstruction and middle ear condition in children under 3 years of age with URTI. MATERIALS AND METHODS: Randomized controlled trial in a day-care centre of Porto, including 44 children randomized to Intervention Group (IG) and Control Group (CG)...
June 8, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29891020/the-increased-incidence-of-bony-metastasis-in-p16-positive-oropharyngeal-carcinoma-a-method-to-enhance-reliability-and-speed-for-performing-anterior-rhinomanometry-and-the-new-soundbridge-middle-ear-implant-and-magnetic-resonance-imaging-compatibility
#17
https://www.readbyqxmd.com/read/29891017/an-alternative-approach-to-mixed-hearing-loss-in-otosclerosis-stapes-surgery-combined-with-an-active-middle-ear-implant
#18
H R F Powell, I Pai, H Ghulam, D Jiang
OBJECTIVE: To report a novel management strategy for mixed hearing loss in advanced otosclerosis. METHODS: A 50-year-old male was referred to St Thomas' Hearing Implant Centre with otosclerosis; he was no longer able to wear conventional hearing aids because of recurrent otitis externa. The patient underwent short process incus vibroplasty (using the Med-El Vibrant Soundbridge device), followed at a suitable interval (six weeks) by stapes surgery. The main outcome measures were: pure tone audiometry, functional gain and monosyllabic word recognition scores...
May 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29890895/otopathologic-changes-in-the-cochlea-following-head-injury-without-temporal-bone-fracture
#19
Reuven Ishai, Renata M Knoll, Jenny X Chen, Kevin Wong, Katherine L Reinshagen, Joseph B Nadol, Aaron K Remenschneider, David H Jung, Elliott D Kozin
Objective Hearing loss following temporal bone (TB) fracture may result from direct transection of the middle and inner ear. The pathophysiology of hearing loss due to head injury without TB fracture, however, is not well understood. Few reports describe otopathologic findings. Herein, we investigate the pathologic findings of patients who sustained a head injury without evidence of a TB fracture. Study Design Otopathology study. Setting Otopathology laboratory. Subjects Subjects with a history of head injury without TB fracture...
June 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29890817/nonshaved-ear-surgery-effect-of-hair-on-surgical-site-infection-of-the-middle-ear-mastoid-surgery-and-patients-preference-for-the-hair-removal
#20
Dong-Hee Lee, Soonil Yoo, Eunhye Shin, Yesun Cho
Background and Objectives: This study aimed 1) to compare the rates of surgical site infection (SSI) between two groups with and without preoperative hair shaving, 2) to compare the bacterial colonization just before the skin incision between them, and 3) to evaluate people's preference for the hair shaving. Subjects and Methods: The retrospective study enrolled cases in which middle ear and mastoid surgery was performed with as well as without hair removal. Main measurement outcomes were the SSI rate within 3 months following the surgery, bacterial culture results obtained from the incision area just before the skin incision, and questionnaire to evaluate the preference for hair shaving from patients with chronic suppurative otitis media but without experience with the ear surgery...
June 14, 2018: Journal of Audiology & Otology
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