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https://www.readbyqxmd.com/read/27921116/-the-pressure-equalizing-function-of-the-eustachian-tube-evaluation-in-a%C3%A2-hypo-hyperbaric-pressure-chamber
#1
S Jansen, M F Meyer, K-B Hüttenbrink, D Beutner
BACKGROUND: The Eustachian tube connects the tympanic cavity (cavum tympani) and the nasopharynx, and enables pressure equalization between the middle ear and ambient pressure. Functional pressure compensation is very important for flying and diving in particular, due to non-physiologically large pressure differences. OBJECTIVE: Evaluation of the pressure-equalizing function of the Eustachian tube is still a clinical challenge. This review article evaluates the existing data...
December 5, 2016: HNO
https://www.readbyqxmd.com/read/27919900/n-acetyl-l-cysteine-and-cysteamine-new-strategies-against-mixed-biofilms-of-non-encapsulated-streptococcus-pneumoniae-and-non-typeable-haemophilus-influenzae
#2
Mirian Domenech, Ernesto García
Acute otitis media, a polymicrobial disease of the middle ear cavity of children, is a significant public health problem worldwide. It is most frequently caused by encapsulated Streptococcus pneumoniae and non-typeable Haemophilus influenzae, although the widespread use of pneumococcal conjugate vaccines is apparently producing an increase in carriage of non-encapsulated S. pneumoniae Frequently, pneumococci and H. influenzae live together in the human nasopharynx forming a self-produced biofilm. Biofilms represent a global medical challenge since the inherent antibiotic resistance of their producers demands the use of high doses of antibiotics over prolonged periods...
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27919628/trivalent-pneumococcal-protein-vaccine-protects-against-experimental-acute-otitis-media-caused-by-streptococcus-pneumoniae-in-an-infant-murine-model
#3
Qingfu Xu, Karin Pryharski, Michael E Pichichero
BACKGROUND: Currently licensed serotype-based pneumococcal vaccines are effective in preventing invasive pneumococcal diseases, but less effective in preventing non-bacteremic pneumonia and acute otitis media (AOM). We previously reported that a trivalent pneumococcal protein recombinant vaccine (PPrV) protected against pneumonia in a murine model. Here we evaluated PPrV protection against AOM in an infant murine model. METHODS: C57BL/6J mice were intramuscularly vaccinated at 1-3weeks of age with monovalent pneumococcal histidine triad protein D (PhtD), or pneumococcal choline binding protein A (PcpA), or detoxified pneumolysin (PlyD1), or trivalent vaccine, and transtympanically challenged at 7-8weeks of age with 1×10(2)CFU of pneumococcal strain BG7322 (6A) or 1×10(4)CFU of pneumococcal nontypeable strain 0702064MEF...
December 2, 2016: Vaccine
https://www.readbyqxmd.com/read/27918787/an-ovine-model-for-exclusive-endoscopic-ear-surgery
#4
Lukas Anschuetz, Marco Bonali, Michael Ghirelli, Francesco Mattioli, Domenico Villari, Marco Caversaccio, Livio Presutti
Importance: With the international spread of exclusive transcanal endoscopic ear surgery, the need for a suitable and affordable surgical training model has grown during the past years. Objective: To develop and validate an ex vivo animal model for exclusive endoscopic ear surgery. Design, Setting, and Animal Models: In an experimental study, we compared ovine and human middle ear anatomy in 4 specimens and assessed the lamb as a model for endoscopic ear surgery...
December 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27918233/patient-satisfaction-after-auditory-implant-surgery-ten-year-experience-from-a-single-implanting-unit-center
#5
Simonetta Monini, Alessandra Bianchi, Rita Talamonti, Francesca Atturo, Chiara Filippi, Maurizio Barbara
CONCLUSIONS: The satisfaction rate of the subjects with an auditory implant appears strictly related to the resulting auditory improvement, and the surgical variables would play a prevailing role in respect to the esthetic factors. OBJECTIVES: To assess the rate of satisfaction in subjects who underwent the surgical application of an auditory device at a single Implanting Center Unit. METHOD: A series of validated questionnaires has been administered to subjects who underwent the surgical application of different auditory devices...
December 5, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27917157/otopathogenic-pseudomonas-aeruginosa-enters-and-survives-inside-macrophages
#6
Rahul Mittal, Christopher V Lisi, Hansi Kumari, M'hamed Grati, Patricia Blackwelder, Denise Yan, Chaitanya Jain, Kalai Mathee, Paulo H Weckwerth, Xue Z Liu
Otitis media (OM) is a broad term describing a group of infectious and inflammatory disorders of the middle ear. Despite antibiotic therapy, acute OM can progress to chronic suppurative otitis media (CSOM) characterized by ear drum perforation and purulent discharge. Pseudomonas aeruginosa is the most common pathogen associated with CSOM. Although, macrophages play an important role in innate immune responses but their role in the pathogenesis of P. aeruginosa-induced CSOM is not known. The objective of this study is to examine the interaction of P...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27915026/effects-of-model-definitions-and-parameter-values-in-finite-element-modeling-of-human-middle-ear-mechanics
#7
Daniel De Greef, Felipe Pires, Joris J J Dirckx
BACKGROUND: Despite continuing advances in finite element software, the realistic simulation of middle ear response under acoustic stimulation continues to be challenging. One reason for this is the wide range of possible choices that can be made during the definition of a model. Therefore, an explorative study of the relative influences of some of these choices is potentially very helpful. METHOD: Three finite element models of the human middle ear were constructed, based on high-resolution micro-computed tomography scans from three different human temporal bones...
November 30, 2016: Hearing Research
https://www.readbyqxmd.com/read/27913068/occult-infratemporal-fossa-neurofibroma-presenting-with-persistent-unilateral-tinnitus-and-middle-ear-effusion-more-than-meets-the-eye
#8
Lucas P Carlstrom, Kathryn M Van Abel, Matthew L Carlson, Eric J Moore, Janalee K Stokken
Herein, we present the case of a previously healthy 54year-old female who developed several weeks of unilateral tinnitus and aural fullness. She subsequently underwent unilateral pressure equalization tube placement at an outside institution after exam demonstrated a middle ear effusion, conductive hearing loss and normal nasopharyngoscopy. Ultimately, an MRI revealed an occult mass in the infratemporal fossa (ITF), which was successfully removed via an endoscopic transnasal ITF approach. Following resection of a histopathologically confirmed benign neurofibroma, she reported complete resolution of her symptoms...
November 23, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27908034/the-effect-of-the-helicotrema-on-low-frequency-loudness-perception
#9
Carlos Jurado, Torsten Marquardt
Below approximately 40 Hz, the cochlear travelling wave reaches the apex, and differential pressure is shunted through the helicotrema, reducing hearing sensitivity. Just above this corner frequency, a resonance feature is often observed in objectively measured middle-ear-transfer functions (METFs). This study inquires whether overall and fine structure characteristics of the METF are also perceptually evident. Equal-loudness-level contours (ELCs) were measured between 20 and 160 Hz for 14 subjects in a purpose-built test chamber...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27905291/two-cases-of-myiasis-of-middle-ear-caused-by-sarcophaga
#10
Erdal Polat, Serhat Sirekbasan, Hakkı Caner İnan
Middle ear myiasis and factors determining the types of flies. To the laboratory in saline with 10% formaldehyde and sent them larvae stereo-microscope (Olympus 10×) were examined. Adult by making one portion of the surviving larvae instar larvae and adults are defined utilizing state properties. The larvae and live larvae of the fly Sarcophaga sp. rendered adults were determined. In both patients, the middle ear causing myiasis flies species Sarcophaga sp. was determined to be.
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27904919/-seasonal-differences-of-tympanogram-and-middle-ear-findings-in-children-german-version
#11
S Knopke, A Böttcher, P Chadha, H Olze, F Bast
BACKGROUND: It is a known fact that bacterial or viral acute otitis media occurs more frequently in the winter months. Only a few older studies on seasonal differences in middle ear findings are available. These studies are based solely on tympanography, without correlation to intraoperative middle ear findings. This study addresses the question of whether seasonal differences can be found in the preoperative tympanogram and in the corresponding intraoperative findings in children with chronic middle ear problems...
November 30, 2016: HNO
https://www.readbyqxmd.com/read/27898607/effects-of-intratympanic-dexamethasone-on-high-dose-radiation-ototoxicity-in-vivo
#12
Christine T Dinh, Si Chen, John Dinh, Stefania Goncalves, Esperanza Bas, Kyle Padgett, Perry Johnson, Nagy Elsayyad, Fred Telischi, Thomas Van De Water
BACKGROUND: Stereotactic radiosurgery for lateral skull base tumors can cause hearing loss when the cochleae are exposed to high doses of single-fraction radiation. Currently, there are no known nondosimetric preventative treatments for radiation-induced ototoxicity. HYPOTHESIS: Intratympanic (IT) dexamethasone (DXM), a synthetic steroid, protects against radiation-induced auditory hair cell (HC) and hearing losses in rats in vivo. METHODS: Seven rats received radiation (12 Gy) to both cochleae...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27897131/an-iatrogenic-cholesteatoma-of-the-squamous-part-of-the-temporal-bone
#13
Daniela Páez Mantilla, Claudio Krstulovic, Manuel Mateos Fernández, Herminio Pérez Garrigues
A cholesteatoma is a relatively common condition within the middle ear cavity, whereas a cholesteatoma of the squamous part of the temporal bone is an exceptionally rare entity. A case of an iatrogenic cholesteatoma located in the squamous part of the temporal bone is presented, which was revealed by an intermittent purulent discharge from an opening above the right ear 20 years after retroauricular myringoplasty. The diagnosis of an iatrogenic cholesteatoma is often made after several years of evolution, sometimes even at the stage of complications...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27896820/ppar%C3%AE-targeted-oral-cancer-treatment-and-additional-utility-of-genomics-analytic-techniques
#14
Nathan Handley, Jacob Eide, Randall Taylor, Beverly Wuertz, Patrick Gaffney, Frank Ondrey
OBJECTIVE: Peroxisome proliferator-activated receptor γ (PPARγ) agonists have been shown to have anti-proliferative, anti-angiogenic, and proapoptotic effects, leading to interest in their use as cancer therapeutics. Pioglitazone, a U.S. Food and Drug Administration-approved type II diabetes medication and PPARγ agonist, may have a role in adjuvant head-and-neck squamous cell carcinoma treatment or prevention. Therefore, the purpose of this study was: 1) to treat oral cavity cancer cells with the PPARγ activator, pioglitazone, to analyze gene expression changes; and 2) to compare those changes with our preexisting genomic data for development of hypothesis-driven additional basic and clinical studies...
November 29, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27896803/the-effect-of-craniokinesis-on-the-middle-ear-of-domestic-chickens-gallus-gallus-domesticus
#15
Raf Claes, Pieter G G Muyshondt, Luc Van Hoorebeke, Jelle Dhaene, Joris J J Dirckx, Peter Aerts
The avian middle ear differs from that of mammalians and contains a tympanic membrane, one ossicle (bony columella and cartilaginous extra-columella), some ligaments and one muscle. The rim of the eardrum (closing the middle ear cavity) is connected to the neurocranium and, by means of a broad ligament, to the otic process of the quadrate. Due to the limited number of components in the avian middle ear, the possibilities of attenuating the conduction of sound seem to be limited to activity of the stapedius muscle...
November 29, 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27896001/long-range-wide-field-swept-source-optical-coherence-tomography-with-gpu-accelerated-digital-lock-in-doppler-vibrography-for-real-time-in-vivo-middle-ear-diagnostics
#16
Dan MacDougall, Joshua Farrell, Jeremy Brown, Manohar Bance, Robert Adamson
We present the design, implementation and validation of a swept-source optical coherence tomography (OCT) system for real-time imaging of the human middle ear in live patients. Our system consists of a highly phase-stable Vernier-tuned distributed Bragg-reflector laser along with a real-time processing engine implemented on a graphics processing unit. We use the system to demonstrate, for the first time in live subjects, real-time Doppler measurements of middle ear vibration in response to sound, video rate 2D B-mode imaging of the middle ear and 3D volumetric B-mode imaging...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27895002/impression-material-in-the-external-and-middle-ear-an-overview-of-the-literature-and-a-stepwise-approach-for-removal
#17
Froukje Verdam, Rinze Tange, Hans Thomeer
Here, we provide a literature overview of cases with protruding molding material for earplugs or hearing aids and subsequent required treatment, including our own cases. Patients at risk are those with impaired tympanic membranes or who previously underwent otologic surgery. Symptoms such as otalgia, tinnitus, and vertigo are alarming but do not always arise. In case of doubt, a CT scan is of additive value to prepare for adequate surgical removal and to limit potential damage. A stepwise approach for the clinician on how to address these challenging cases is presented, based upon the literature and our own experience...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27895001/surgical-management-and-hearing-outcome-of-traumatic-ossicular-injuries
#18
Stefan Delrue, Nicolas Verhaert, Joost van Dinther, Andrzej Zarowski, Thomas Somers, Christian Desloovere, Erwin Offeciers
OBJECTIVE: The purpose of this study was to investigate etiological, clinical, and pathological characteristics of traumatic injuries of the middle ear ossicular chain and to evaluate hearing outcome after surgery. MATERIAL AND METHODS: Thirty consecutive patients (31 ears) with traumatic ossicular injuries operated on between 2004 and 2015 in two tertiary referral otologic centers were retrospectively analyzed. Traumatic events, clinical features, ossicular lesions, treatment procedures, and audiometric results were evaluated...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27889249/analysis-of-streptococcus-pneumoniae-and-haemophilus-influenzae-isolated-from-middle-ear-fluid-before-and-after-the-introduction-of-government-subsidies-for-pneumococcal-and-h-%C3%A2-influenzae-type-b-vaccines-in-japan
#19
Tadashi Hoshino, Noriko Takeuchi, Chie Fukasawa, Shoko Hirose, Hideyuki Okui, Hiroko Sato, Mari Sato, Yukiko Arimoto, Atsuko Nakano, Naruhiko Ishiwada
This study aimed to identify trends in frequency, serotype, and antimicrobial susceptibility of Streptococcus pneumoniae and Haemophilus influenzae isolated from middle ear fluid specimens of children aged≤15 years (mean, 2 years), before and after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) and the H. influenzae type b vaccine, at a pediatric facility in Japan. Sixty-six S. pneumoniae and 88 H. influenzae strains were isolated from 820 middle ear fluid samples. Serotyping and antimicrobial susceptibility testing were performed...
November 23, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27880959/morphology-and-ciliary-motion-of-the-middle-ear-mucosa-of-neonatal-and-adult-gerbils
#20
Jun Li, Huizhan Liu, Nancy T He, Na Shen, Yi Li
BACKGROUND/AIMS: Since the middle ear cavity plays an important role in middle ear effusion, the goal of this study is to examine the morphological and functional development of the middle ear mucosa in neonatal and adult gerbils. METHODS: Gerbils aged between postnatal day 1 (P1) and P26 were used for the experiments. The morphological development of the middle ear cavity was measured by using the celloidin embedding method and scanning electronic microscope. Ciliary motion was determined and calibrated by a photodiode-based measurement system...
November 24, 2016: ORL; Journal for Oto-rhino-laryngology and its related Specialties
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