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https://www.readbyqxmd.com/read/28811566/injectable-phosphorescence-based-oxygen-biosensors-identify-post-ischemic-reactive-hyperoxia
#1
Jennifer S Chien, Mahmoud Mohammed, Hysem Eldik, Mohamed M Ibrahim, Jeremy Martinez, Scott P Nichols, Natalie Wisniewski, Bruce Klitzman
Novel injectable biosensors were used to measure interstitial oxygenation before, during, and after transient ischemia. It is well known that reactive hyperemia occurs following a period of ischemia. However, increased blood flow does not necessarily mean increased oxygen tension in the tissue. Therefore, the purpose of this study was to test the hypothesis that tissue reactive hyperoxia occurs following release of hind-limb tourniquet occlusions. Rats were injected with bilateral hind-limb biosensors and were simultaneously subjected to a unilateral femoral vessel ligation...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810961/resuscitation-of-hypotensive-traumatic-brain-injured-animals-with-spray-dried-plasma-does-not-adversely-alter-physiology-and-improves-blood-brain-barrier-function
#2
Steven McDaniel, Stephanie Golla, Anthony N Moore, Joe DaCorta, Arthur Bode, Shibani Pati, Pramod K Dash, Jing Zhao
INTRODUCTION: According to the Defense and Veterans Brain Injury Center and the Armed Forces Health Surveillance Center, the number of soldiers who have sustained a traumatic brain injury (TBI) has risen dramatically over the past decade. Studies have shown that brain damage can be exacerbated if blood loss occurs (often occurring in polytrauma). As blood supply is critical for brain function and survival, TBI patients must be properly resuscitated to maintain blood volume, blood pressure, and cerebral perfusion...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28803174/intraoperative-vascular-neuromonitoring-in-patients-with-subarachnoid-hemorrhage-a-pilot-study-using-combined-laser-doppler-spectrophotometry
#3
Emilija Schmitz, Barbara Bischoff, Dennis Wolf, Hubert Schmitt, Ilker Y Eyupoglu, Karl Roessler, Michael Buchfelder, Björn Sommer
OBJECTIVE: Intraoperative monitoring of cerebral microcirculation in patients with subarachnoid hemorrhage (SAH) may predict the postoperative neurological outcome. In this pilot study, we examined the value of a novel non-invasive real-time measurement technique to detect changes in local microcirculation. METHODS: We used the laser-Doppler spectrophotometry system "Oxygen-to-see(O2C)" in 14 patients with SAH Hunt & Hess grade 2 to 5, who underwent microsurgical clipping of cerebral aneurysms...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28801985/between-day-reliability-of-local-thermal-hyperaemia-in-the-forearm-and-index-finger-using-single-point-laser-doppler-flowmetry
#4
Gregory W McGarr, Gary J Hodges, Stephen S Cheung
OBJECTIVE: To assess between-day reliability for local thermal hyperaemia (LTH) in glabrous and non-glabrous index finger skin and non-glabrous forearm skin, with single point laser-Doppler flowmetry. METHODS: Part-1: In healthy, habitually active males (n=10), LTH was examined twice (~7-10 d apart) for both skin types on the index finger. Part-2: Identical testing was performed on the volar forearm. Local heating (33-42°C at 1°C·20 s(-1) +20 min at 44°C) was performed at all skin sites and baseline, initial peak, and plateau phases were identified...
August 12, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28801284/-yiqihuoxue-prescription-promotes-nerve-regeneration-by-mir-124-mediated-regulation-of-wnt-signaling-in-rats
#5
Hui Tan, Jian Wang, Ting-Ting Yin, Ling He, Yong Deng, Feng Li, Yu-Feng Wang
OBJECTIVE: To investigate the effect of Yiqihuoxue prescription (NLXT) on nerve regeneration in MCAO-R rat models of qi deficiency and blood stasis syndrome and explore the underlying mechanisms. METHODS: The rats were randomized into 4 groups, namely the control group, model group, NLXT group and TXL group. The rats in NLXT group and TXL group were treated with gavage of NLXT and TXL solutions, respectively. The NFDS, QDSS and BSSS of the rats were evaluated. The regional cerebral blood flow (rCBF) were dynamically monitored with laser Doppler scanning, and the volume of cerebral infarction was detected with TTC-dye; the expression levels of nestin and BrdU were assayed with immunohistochemistry and mmunofluorescent staining...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28800207/optically-derived-metabolic-and-hemodynamic-parameters-predict-hippocampal-neurogenesis-in-the-btbr-mouse-model-of-autism
#6
David Abookasis, Danit Lerman, Hava Roth, Mati Tfilin, Gadi Turgeman
In the present study, we made use of dual-wavelength laser speckle imaging (DW-LSI) to assess cerebral blood flow in the BTBR genetic mouse model of Autism Spectrum Disorder, as well as control (C57Bl/6J) mice. Since the deficits in social behavior demonstrated by BTBR mice are attributed to changes in neural tissue structure and function, we postulated that these changes can be detected optically using DW-LSI. BTBR mice demonstrated reductions in both cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2 ), as suggested by studies using conventional neuroimaging technologies to reflect impaired neuronal activation and cognitive function...
August 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28796601/time-dependent-behavior-of-microvascular-blood-flow-and-oxygenation-a-predictor-of-functional-outcomes
#7
Kasia Z Kuliga, Rodney Gush, Geraldine F Clough, Andrew J Chipperfield
OBJECTIVE: This study investigates the time-dependent behaviour and algorithmic complexity of low frequency, periodic oscillations in blood flux and oxygenation signals from the microvasculature. METHODS: Microvascular blood flux (BF) and oxygenation (OXY: oxyHb, deoxyHb, totalHb and SO2%) was recorded from 15 healthy young adult males using combined laser Doppler fluximetry and white light spectroscopy with local skin temperature clamped to 33C and during local thermal hyperaemia (LTH) at 43C...
August 7, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28792613/peripheral-perfusion-and-oxygenation-in-areas-of-risk-of-skin-integrity-impairment-exposed-to-pressure-patterns-a-phase-i-trial-poter-study
#8
Silvia Garcia-Mayor, Juan Carlos Morilla-Herrera, Inmaculada Lupiáñez-Pérez, Shakira Kaknani Uttumchandani, Álvaro Leon Campos, Marta Aranda-Gallardo, Ana Belén Moya-Suárez, José Miguel Morales-Asencio
AIM: To analyse the changes in peripheral oxygenation and microvascular flow in tissues subjected to different pressure regimes in healthy subjects and in hospitalised patients. BACKGROUND: The presence of pressure ulcers in hospitalised patients is a common complication that has a negative impact on health and often prolongs hospital stay and increases health care costs. DESIGN: Experimental non-controlled, non-randomised study in two phases: preclinical and clinical...
August 9, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28777054/an-investigation-of-skin-perfusion-in-venous-leg-ulcer-after-exercise
#9
Omar Mutlak, Mohammed Aslam, Nigel J Standfield
INTRODUCTION: A venous leg ulcer (VLU) has a major impact on the quality of life and functional ability of individuals, but no single treatment is yet effective. This study investigates the changes induced by dorsiflexion exercise on skin perfusion in VLU patients to achieve a better understanding of venous ulcer pathophysiology. METHODS: Seventy-eight venous leg ulcer patients were randomised into four groups. The non-exercise groups included a control group (n = 18) and a compression therapy group (n = 20) and the exercise groups included an exercise-only group (n = 20) and a compression and exercise group (n = 20)...
July 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28776087/efficacy-of-in-vivo-electroporation-mediated-il-10-gene-delivery-on-survival-of-skin-flaps
#10
S Morteza Seyed Jafari, Maziar Shafighi, Helmut Beltraminelli, Benedikt Weber, Ralph A Schmid, Thomas Geiser, Amiq Gazdhar, Robert E Hunger
Despite advances in understanding the underlying mechanisms of flap necrosis and improvement in surgical techniques, skin flap necrosis after reconstructive surgery remains a crucial issue. We investigated the efficacy of electroporation-mediated IL-10 gene transfer to random skin flap with an aim to accelerate wound healing and improve skin flap survival. Nine male Wistar rats (300-330 g) were divided in two groups (a) control group (n = 5), only surgery no gene transfer, and (b) experimental group, received electroporation-mediated IL-10 gene transfer 24 h before the surgery as prophylaxis (n = 4)...
August 3, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28774328/curcumin-induces-therapeutic-angiogenesis-in-a-diabetic-mouse-hindlimb-ischemia-model-via-modulating-the-function-of-endothelial-progenitor-cells
#11
Jinzhi You, Jiacheng Sun, Teng Ma, Ziying Yang, Xu Wang, Zhiwei Zhang, Jingjing Li, Longgang Wang, Masaaki Ii, Junjie Yang, Zhenya Shen
BACKGROUND: Neovascularization is impaired in diabetes mellitus, which leads to the development of peripheral arterial disease and is mainly attributed to the dysfunction of endothelial progenitor cells (EPCs). Previous studies proved the promotional effect of curcumin on neovascularization in wound healing of diabetes. Thus, we hypothesize that curcumin could promote neovascularization at sites of hindlimb ischemia in diabetes and might take effect via modulating the function of EPCs...
August 3, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28772431/inspection-of-piezoceramic-transducers-used-for-structural-health-monitoring
#12
Inka Mueller, Claus-Peter Fritzen
The use of piezoelectric wafer active sensors (PWAS) for structural health monitoring (SHM) purposes is state of the art for acousto-ultrasonic-based methods. For system reliability, detailed information about the PWAS itself is necessary. This paper gives an overview on frequent PWAS faults and presents the effects of these faults on the wave propagation, used for active acousto-ultrasonics-based SHM. The analysis of the wave field is based on velocity measurements using a laser Doppler vibrometer (LDV). New and established methods of PWAS inspection are explained in detail, listing advantages and disadvantages...
January 16, 2017: Materials
https://www.readbyqxmd.com/read/28772005/the-effects-of-antioxidants-on-ocular-blood-flow-in-patients-with-glaucoma
#13
Alon Harris, Josh Gross, Nicholas Moore, Thai Do, Amelia Huang, Willy Gama, Brent Siesky
PURPOSE: To investigate the effects of an antioxidant dietary supplement that includes Ginkgo biloba, on retinal and retrobulbar blood flow in patients with open-angle glaucoma (OAG). METHODS: Forty-five patients with confirmed OAG were enroled in a randomized, double blinded, placebo-controlled cross-over study. Baseline and postadministration measurements of intraocular pressure (IOP), ocular perfusion pressure (OPP), retrobulbar blood flow, and retinal capillary blood flow were non-invasively measured (ultrasound and laser Doppler modalities, respectively) before and one month after antioxidant nutraceuticals and placebo administration...
August 3, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28762949/laser-doppler-flowmetry-and-transcutaneous-oximetry-in-chronic-skin-ulcers-a-comparative-evaluation
#14
Edoardo Raposio, Nicolò Bertozzi, Rebecca Moretti, Eugenio Grignaffini, Michele P Grieco
INTRODUCTION/OBJECTIVE: Laser Doppler Flowmetry (LDF) and transcutaneous oximetry (TcpO2) are established methods for investigating cutaneous perfusion. To date, no study previously performed has compared data obtained from these 2 methodologies in cases of chronic cutaneous ulcers. MATERIALS AND METHODS: Laser Doppler Flowmetry and TcpO2 were performed in 25 consecutive outpatients with chronic lower limb ulcers (group A, experimental; 9 women and 16 men; mean age 67 years [range, 52-81 years]) and 25 age- and sex-matched healthy control subjects (group B, control) enrolled for the study...
April 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28761667/correlation-between-capillary-oxygen-saturation-and-small-intestinal-wall-thickness-in-the-equine-colic-patient
#15
Elisabeth Mirle, Anna Wogatzki, Robert Kunzmann, Axel M Schoenfelder, Lutz F Litzke
The surgical evaluation of haemorrhagic infarcted intestine and the decision for or against bowel resection require a lot of experience and are subjective. The aim of this prospective, clinical study was to examine the correlation between oxygen saturation and small intestinal wall (IW) thickness, using two objective methods. In 22 colicky horses, the blood flow, oxygen saturation and relative amount of haemoglobin were measured intraoperatively via laser Doppler and white light spectroscopy (O2C, oxygen to see, LEA Medizintechnik) at six measuring points (MPs) in small and large intestines...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/28758555/sequential-motion-of-the-ossicular-chain-measured-by-laser-doppler-vibrometry
#16
Yasuomi Kunimoto, Kensaku Hasegawa, Shiro Arii, Hideyuki Kataoka, Hiroaki Yazama, Junko Kuya, Kazunori Fujiwara, Hiromi Takeuchi
OBJECTIVE: In order to help a surgeon make the best decision, a more objective method of measuring ossicular motion is required. METHODS: A laser Doppler vibrometer was mounted on a surgical microscope. To measure ossicular chain vibrations, eight patients with cochlear implants were investigated. To assess the motions of the ossicular chain, velocities at five points were measured with tonal stimuli of 1 and 3 kHz, which yielded reproducible results. The sequential amplitude change at each point was calculated with phase shifting from the tonal stimulus...
July 31, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28756648/objective-assessment-of-hearing-during-second-stage-of-tympanoplasty-surgical-technique-and-measurement-methodology-presented-in-ten-patients
#17
Kazimierz Niemczyk, Krzysztof Morawski, Rafael Delgado, Antoni Bruzgielewicz, Magdalena Lachowska
In this paper, a complete integrated method of intraoperative monitoring of hearing (IOMH) during ossiculoplasty performed via posterior tympanotomy is presented. The method integrates auditory steady state responses (ASSR) with Laser-Doppler Vibrometry (LDV) and allows intraoperative optimization of ossicular prosthesis positioning and coupling. Both ASSR and LDV are acquired simultaneously. The results of the integrated measurements are analyzed and evaluated automatically on-line which makes this strategy unaffected by individual differences in interpretations of collected recordings...
July 30, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28753355/demonstrating-an-in%C3%A2-situ-topological-band-transition-in-cylindrical-granular-chains
#18
R Chaunsali, E Kim, A Thakkar, P G Kevrekidis, J Yang
We numerically investigate and experimentally demonstrate an in situ topological band transition in a highly tunable mechanical system made of cylindrical granular particles. This system allows us to tune its interparticle stiffness in a controllable way, simply by changing the contact angles between the cylinders. The spatial variation of particles' stiffness results in an in situ transition of the system's topology. This manifests as the emergence of a boundary mode in the finite system, which we observe experimentally via laser Doppler vibrometry...
July 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28751169/differences-in-laser-doppler-indices-between-skin-surface-measurement-sites-in-subjects-with-diabetes
#19
Hsin Hsiu, Hsiao-Feng Hu, Hung-Chi Tsai
This study performed laser-Doppler flowmetry (LDF) measurements with the aim of identifying differences in diabetes-induced microcirculatory-blood-flow (MBF) responses between the following skin surface measurement sites: an acupoint around the wrist, an acupoint around the ankle, and a nearby nonacupoint around the ankle. The 67 study subjects were assigned to diabetic, prediabetic, and healthy groups according to the results of oral glucose tolerance tests. Beat-to-beat and spectral analyses were applied to the LDF waveform to obtain the foot delay time (FDT), the flow rise time (FRT), and the relative energy contributions (RECs) in five frequency bands...
July 25, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28747975/blood-flow-improving-activity-of-methyl-jasmonate-treated-adventitious-roots-of-mountain-ginseng
#20
Young-Hwan Ban, Yeseul Cha, Jieun Choi, Eun Suk An, Ji Young Lee, Nu Ry Han, Da Woom Seo, Gooyoung Jung, Da-Hye Jeong, Man Hee Rhee, Ehn-Kyoung Choi, Yun-Bae Kim
Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% FeCl3-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe...
June 2017: Laboratory Animal Research
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