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https://www.readbyqxmd.com/read/29907232/intramuscular-e-selectin-adeno-associated-virus-gene-therapy-promotes-wound-healing-in-an-ischemic-mouse-model
#1
Punam P Parikh, Roberta M Lassance-Soares, Hongwei Shao, Manuela M Regueiro, Yan Li, Zhao-Jun Liu, Omaida C Velazquez
BACKGROUND: Poor wound healing in critical limb ischemia (CLI) is attributed to impaired neovascularization and reperfusion. Optimizing the ischemic wound with adhesion molecules that enhance stem cell homing may revolutionize treatment. The purpose of this study is to test the efficacy of adhesion molecule E-selectin on wound healing in an ischemic mouse wound. METHODS: Adult FVB/NJ mice underwent unilateral femoral artery and vein ligation to induce CLI. A 4-mm punch biopsy wound was created on the anterior thigh to simulate ischemic wounds...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29904181/relativistic-doppler-boosted-%C3%AE-rays-in-high-fields
#2
Remi Capdessus, Martin King, Dario Del Sorbo, Matthew Duff, Christopher P Ridgers, Paul McKenna
The relativistic Doppler effect is one of the most famous implications of the principles of special relativity and is intrinsic to moving radiation sources, relativistic optics and many astrophysical phenomena. It occurs in the case of a plasma sail accelerated to relativistic velocities by an external driver, such as an ultra-intense laser pulse. Here we show that the relativistic Doppler effect on the high energy synchrotron photon emission (~10 MeV), strongly depends on two intrinsic properties of the plasma (charge state and ion mass) and the transverse extent of the driver...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29904136/design-of-a-high-precision-and-non-contact-dynamic-angular-displacement-measurement-with-dual-laser-doppler-vibrometers
#3
Lei Chen, Dengwei Zhang, Yilan Zhou, Cheng Liu, Shuangliang Che
A wide dynamic range, high precision, non-contact and large bandwidth angular displacement measurement (ADM) is greatly necessary for the applications such as industrial control and military equipment. This paper proposes a simple and effective ADM method based on Doppler Effect, heterodyne detection and diffuse reflection, which can fulfill these requirements simultaneously. Two beams of parallel light generated by a pair of laser Doppler vibrometers are incident upon the surface of rotational target, then data processing unit acquires the velocity of dual laser incident points on the moving target, and resolves the rotational angular displacement and translation displacement of target through the relationship between dual laser beams dynamically...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902900/-preliminary-study-on-two-analytical-methods-for-evaluation-of-traditional-chinese-medicine-syndromes-model-in-rats-with-blood-stasis-due-to-sleep-deprivation
#4
Ting-Ting Hao, Hao Guo, Jian-Xun Liu, Jin-Cheng Chen, Jian-Xun Ren, Cheng-Ren Lin, Jun-Guo Ren
The comparison on evaluating blood stasis syndrome in sleep deprived rats was carried out by using R, G, B image analysis of Tongue and palm as well as auricle, palm surface laser Doppler flow perfusion. The experiment was performed by means of a small platform on the water environment for sleep deprivation. The rats were weekly weighed at fixed time, and their macroscopic signs were observed; and their tongue and palm images of the control and model group were respectively collected by the SLR camera at the 2nd, 4th and 6th week...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29901290/-outcomes-of-er-yag-laser-treatment-of-stress-urinary-incontinence-in-women
#5
A I Neimark, A Yu Yakovleva, G A Lapii
AIM: To evaluate the effectiveness of a new method of treatment for stress urinary incontinence in women using an ER: YAG laser in SMOOTH mode and investigate pathophysiological and pathomorphological changes induced by erbium laser. MATERIALS AND METHODS: This study comprised 98 women aged 37-63 years, who between 2014 and 2016 were diagnosed with SUI (type 1 and 2a, 2b) and grade 0-2 vaginal prolapse. The treatment was performed with a 2940 nm Er:YAG laser (Fotona, Slovenia) using a SMOOTH mode...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29900347/endothelial-microparticles-and-vascular-parameters-in-subjects-with-and-without-arterial-hypertension-and-coronary-artery-disease
#6
Roberto Sansone, Maximilian Baaken, Patrick Horn, Dominik Schuler, Ralf Westenfeld, Nicolas Amabile, Malte Kelm, Christian Heiss
Endothelial microparticles (EMPs) are markers of endothelial injury and activation. The role of EMPs in arterial hypertension is not well understood and EMPs are increased both in arterial hypertension and coronary artery disease (CAD). The data presented here show EMPs as defined by CD31+ /41- , CD62e+ , and CD144+ surface markers and vascular hemodynamic parameters including office and central blood pressure, heart rate, aortic augmentation index, pulse wave velocity, flow-mediated dilation, nitroglycerin-mediated dilation, brachial artery diameter, hyperemic wall shear stress, and laser Doppler perfusion of the cutaneous microcirculation of normotensives and hypertensives with and without CAD...
August 2018: Data in Brief
https://www.readbyqxmd.com/read/29894856/the-response-of-peripheral-microcirculation-to-gravity-induced-changes
#7
Zehava Ovadia-Blechman, Ashley Gritzman, Maya Shuvi, Benjamin Gavish, Vered Aharonson, Neta Rabin
BACKGROUND: The peripheral microcirculation supplies fresh blood to the small blood vessels, providing oxygen and nutrients to the tissues, removing waste, and maintaining normal homeostatic conditions. The goal of this study was to characterize the response of the peripheral microcirculation, in terms of blood flow and tissue oxygenation variables, to gravity-induced changes. METHODS: The study included 20 healthy volunteers and the experiment involved monitoring central and peripheral variables with the right hand positioned at different heights...
June 5, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29889530/immunopet-of-cd146-in-a-murine-hindlimb-ischemia-model
#8
Carolina A Ferreira, Reinier Hernandez, Yunan Yang, Hector F Valdovinos, Jonathan W Engle, Weibo Cai
Peripheral Arterial Disease (PAD) is a chronic occlusion of lower-extremity arteries distal to the aortic bifurcation attributable to atherosclerosis. PAD is associated with an elevated risk of morbidity and mortality as well as of deterioration of the quality of life with claudication and chronic leg ischemia being the most frequent complications. Therapeutic angiogenesis is a promising therapeutic strategy that aims to restore the blood flow to the ischemic limb. In this context, assessing the efficacy of pro-angiogenic treatment using a reliable non-invasive imaging technique would greatly benefit the implementation of this therapeutic approach...
June 11, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29889061/early-sign-of-microangiopathy-in-systemic-sclerosis-the-significance-of-cold-stress-test-in-dynamic-laser-doppler-flowmetry
#9
Sebastian Yu, Stephen Chu-Sung Hu, Hsin-Su Yu, Yi-Ying Chin, Yang-Chun Cheng, Chih-Hung Lee
BACKGROUND: Skin physiology measurement is receiving more attention for detecting vasculopathy in systemic sclerosis (SSc). Laser Doppler flowmetry (LDF) is a widely used physiological measurement to assess cutaneous microcirculation. However, findings of LDF may be normal during early stage of microangiopathy in SSc. OBJECTIVE: We hypothesized that cold stress test combined with LDF could detect early-stage microangiopathy in patients with SSc. METHODS: A 67-year-old male came with multiple ulcerations on his fingers for one year...
June 5, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29885586/a-novel-bioscaffold-with-naturally-occurring-extracellular-matrix-promotes-hepatocyte-survival-and-vessel-patency-in-mouse-models-of-heterologous-transplantation
#10
Wei Yang, Quanyu Chen, Renpei Xia, Yujun Zhang, Ling Shuai, Jiejuan Lai, Xiaolin You, Yan Jiang, Ping Bie, Leida Zhang, Hongyu Zhang, Lianhua Bai
BACKGROUND: Naïve decellularized liver scaffold (nDLS)-based tissue engineering has been impaired by the lack of a suitable extracellular matrix (ECM) to provide "active micro-environmental" support. AIM: The present study aimed to examine whether a novel, regenerative DLS (rDLS) with an active ECM improves primary hepatocyte survival and prevents thrombosis. METHODS: rDLS was obtained from a 30-55% partial hepatectomy that was maintained in vivo for 3-5 days and then perfused with detergent in vitro...
May 28, 2018: Biomaterials
https://www.readbyqxmd.com/read/29881274/cholesteryl-oleate-loaded-cationic-solid-lipid-nanoparticles-as-carriers-for-efficient-gene-silencing-therapy
#11
Marc Suñé-Pou, Silvia Prieto-Sánchez, Younes El Yousfi, Sofía Boyero-Corral, Anna Nardi-Ricart, Isaac Nofrerias-Roig, Pilar Pérez-Lozano, Encarna García-Montoya, Montserrat Miñarro-Carmona, Josep Ramón Ticó, Josep Mª Suñé-Negre, Cristina Hernández-Munain, Carlos Suñé
Background: Cationic solid lipid nanoparticles (SLNs) have been given considerable attention for therapeutic nucleic acid delivery owing to their advantages over viral and other nanoparticle delivery systems. However, poor delivery efficiency and complex formulations hinder the clinical translation of SLNs. Aim: The aim of this study was to formulate and characterize SLNs incorporating the cholesterol derivative cholesteryl oleate to produce SLN-nucleic acid complexes with reduced cytotoxicity and more efficient cellular uptake...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29880004/soft-tissue-microcirculation-around-the-healthy-achilles-tendon-a-cross-sectional-study-focusing-on-the-achilles-tendon-and-dorsal-surgical-approaches-to-the-hindfoot
#12
Kajetan Klos, Boyko Gueorguiev, John Bennet Carow, Ali Modabber, Sven Nebelung, Bong-Sung Kim, Klemens Horst, Christian David Weber, Matthias Knobe
BACKGROUND: Dorsal approaches to the hindfoot are frequently used. Furthermore, the vascular supply is discussed as a possible cause for ruptures and degeneration of the Achilles tendon. The aim of this study was to evaluate the microperfusion of three possible posterior approaches to the hindfoot and different areas of the Achilles tendon. METHODS: In 111 subjects, a laser Doppler/white light spectroscopy was used to measure microperfusion in terms of blood flow (Flow) and capillary venous oxygen saturation (SO2) in the hindfoot and Achilles tendon...
June 7, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29877391/perturbative-solution-to-the-two-component-atmosphere-dial-equation-for-improving-the-accuracy-of-the-retrieved-absorption-coefficient
#13
Catharine E Bunn, Kevin S Repasky, Matthew Hayman, Robert A Stillwell, Scott M Spuler
Thermodynamic profiling using ground-based remote sensing instruments such as differential absorption lidar (DIAL) has the potential to fill observational needs for climate and weather-related research and improve weather forecasting. The DIAL technique uses the return signal resulting from atmospherically scattered light at two closely spaced wavelengths to determine the range-resolved absorption coefficient for a molecule of interest. Temperature profiles can be retrieved using a temperature-sensitive absorption feature of a molecule with a known mixing ratio such as oxygen...
June 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29873123/folic-acid-supplementation-does-not-attenuate-thermoregulatory-or-cardiovascular-strain-of-older-adults-exposed-to-extreme-heat-and-humidity
#14
Daniel Gagnon, Steven A Romero, Matthew N Cramer, Ken Kouda, Paula Ys Poh, Hai Ngo, Ollie Jay, Craig G Crandall
What is the central question of this study? Few studies have evaluated potential strategies to alleviate thermoregulatory and cardiovascular strain of older adults during heat exposure. We studied the effects of folic acid supplementation on thermoregulatory and cardiovascular responses of healthy older adults exposed to extreme heat and humidity. What is the main finding and its importance? Supplementation did not affect whole-limb blood flow/vasodilation, core and skin temperatures, heart rate, blood pressure and cardiac output...
June 5, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29869899/effects-of-morroniside-on-the-viability-of-random-skin-flaps-in-rats
#15
Yuting Lin, Bin Lin, Dingsheng Lin
OBJECTIVE: The purpose of our experiment was to determine whether morroniside can improve the survival of ischemic skin flaps in rats. METHODOLOGY: A total of 40 male Sprague-Dawley rats were randomly divided into two groups (control group and treatment group). Modified McFarlane flaps were performed (causally based, 9 cm × 3 cm). The percentage of survival of each flap was calculated. Flap blood flows were measured by Laser-Doppler flowmeter. Flap vasculature was assessed by angiography after Lead oxide-gelatin injection...
June 5, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29869055/pyruvate-kinase-m2-increases-angiogenesis-neurogenesis-and-functional-recovery-mediated-by-upregulation-of-stat3-and-focal-adhesion-kinase-activities-after-ischemic-stroke-in-adult-mice
#16
Dongdong Chen, Ling Wei, Zhi-Ren Liu, Jenny J Yang, Xiaohuan Gu, Zheng Z Wei, Li-Ping Z Liu, Shan Ping Yu
Ischemic stroke remains a serious threat to human life. Generation of neuronal and vascular cells is an endogenous regenerative mechanism in the adult brain, which may contribute to tissue repair after stroke. However, the regenerative activity is typically insufficient for significant therapeutic effects after brain injuries. Pyruvate kinase isoform M2 (PKM2) is a key regulator for energy metabolism. PKM2 also has nonmetabolic roles involving regulations of gene expression, cell proliferation, and migration in cancer cells as well as noncancerous cells...
June 4, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29866368/different-modalities-of-exercise-improve-macrovascular-function-but-not-microvascular-function-in-metabolic-syndrome-the-resolve-randomized-trial
#17
Agnès Vinet, Philippe Obert, Daniel Courteix, Robert Chapier, Bruno Lesourd, Julien Verney, Frédéric Dutheil, Guillaume Walther
OBJECTIVE: To determine which modality of exercise program (endurance and/or resistance dominance) is the most effective for improving vascular function in the micro- and macrocirculation in metabolic syndrome (MetS). METHODS: Sixty-two MetS patients were enrolled in a 6-month lifestyle intervention program based on diet and exercise training. Each participant was randomly assigned to one of 3 groups categorized by exercise modality (e.g. high-intensity resistance or endurance training, or combined moderate-intensity)...
May 23, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29862855/a-feasibility-study-of-a-novel-low-level-light-therapy-for-digital-ulcers-in-systemic-sclerosis
#18
M Hughes, T Moore, J Manning, J Wilkinson, S Watson, P Samraj, G Dinsdale, C Roberts, L E Rhodes, A L Herrick, A Murray
BACKGROUND: Locally acting, well-tolerated treatments for systemic sclerosis (SSc) digital ulcers (DUs) are needed. OBJECTIVES: Our primary aim was to investigate the safety, feasibility and tolerability of a novel low level light therapy (LTTT). A secondary aim was to tentatively assess efficacy. METHODS: A custom-built device comprising infrared (850nm), red (660nm) and violet (405nm) LEDs was utilised. DUs were irradiated with 10J/cm2 twice weekly for three weeks, with follow-up at weeks 4&8...
June 4, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29862837/bioengineering-with-endothelial-progenitor-cells-improves-the-vascular-engraftment-of-transplanted-human-islets
#19
Liza Grapensparr, Gustaf Christoffersson, Per-Ola Carlsson
Pancreatic islets isolated for transplantation are disconnected from their vascular supply and need to establish a new functional network posttransplantation. Due to poor revascularization, prevailing hypoxia with correlating increased apoptosis rates in experimental studies can be observed for months posttransplantation. Endothelial progenitor cells (EPCs) are bone marrow-derived cells that promote neovascularization. The present study tested the hypothesis that EPCs, isolated from human umbilical cord blood, could be coated to human islet surfaces and be used to promote islet vascular engraftment...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29862266/redesign-of-the-hannover-coupler-optimized-vibration-transfer-from-floating-mass-transducer-to-round-window
#20
Mathias Müller, Rolf Salcher, Nils Prenzler, Thomas Lenarz, Hannes Maier
Introduction: In order to reduce the large variations in clinical outcomes of patients with implanted MED-EL Floating Mass Transducer (FMT) at the round window (RW), several approaches were proposed to optimize FMT-RW coupling. Our previous study showed improved FMT-RW coupling by applying static RW loads utilizing the "Hannover Coupler" (HC) FMT-prosthesis but also demonstrated insufficient low frequency performance. Hence, a redesigned HC version (HCv2) was investigated in this study...
2018: BioMed Research International
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