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https://www.readbyqxmd.com/read/28109295/a-randomised-active-and-placebo-controlled-three-period-crossover-trial-to-investigate-short-term-effects-of-the-dipeptidyl-peptidase-4-inhibitor-linagliptin-on-macro-and-microvascular-endothelial-function-in-type-2-diabetes
#1
Thomas Jax, Alin Stirban, Arne Terjung, Habib Esmaeili, Andreas Berk, Sandra Thiemann, Robert Chilton, Maximilian von Eynatten, Nikolaus Marx
BACKGROUND: Studies of dipeptidyl peptidase (DPP)-4 inhibitors report heterogeneous effects on endothelial function in patients with type 2 diabetes (T2D). This study assessed the effects of the DPP-4 inhibitor linagliptin versus the sulphonylurea glimepiride and placebo on measures of macro- and microvascular endothelial function in patients with T2D who represented a primary cardiovascular disease prevention population. METHODS: This crossover study randomised T2D patients (n = 42) with glycated haemoglobin (HbA1c) ≤7...
January 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28108308/role-of-cyclooxygenase-in-the-vascular-response-to-locally-delivered-acetylcholine-in-caucasian-and-african-descent-individuals
#2
Matthew J Maley, James R House, Michael J Tipton, Clare M Eglin
INTRODUCTION: Individuals of African descent (AFD) are more susceptible to non-freezing cold injury (NFCI) compared with Caucasian individuals (CAU). Vasodilatation to acetylcholine (ACh) is lower in AFD compared with CAU in the non-glabrous foot and finger skin sites; the reason for this is unknown. Prostanoids are responsible, in part, for the vasodilator response to ACh, however it is not known whether the contribution differs between ethnicities. METHODS: 12 CAU and 12 AFD males received iontophoresis of ACh (1 w/v%) on non-glabrous foot and finger skin sites following placebo and then aspirin (600mg, single blinded)...
January 17, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28106663/the-role-of-laser-doppler-flowmetry-tests-serum-angiopoietin-2-asymmetric-and-symmetric-dimethylarginine-to-predict-outcome-in-chronic-kidney-disease
#3
János Nemcsik, Orsolya Cseprekál, József Egresits, Jan Kielstein, Philipp Kümpers, Alexander Lukasz, Ádám Tabák, Adrienn Marton, Zsófia K Németh, Zoltán Járai, Gabriella Godina, László Sallai, Katalin Farkas, István Kiss, András Tislér
OBJECTIVE: The role of biochemical and functional markers of microvascular dysfunction to predict cardiovascular outcomes in nondialyzed chronic kidney disease (CKD) remains unclear. In this prospective cohort study, we assessed whether biochemical [serum level of angiopoietin-2 (Ang-2), asymmetric and symmetric dimethylarginin] and functional (laser Doppler flowmetry) measures of microvascular function predicted cardiovascular events, cardiovascular and all-cause mortality in CKD patients...
January 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28103890/the-association-between-diabetes-and-dermal-microvascular-dysfunction-non-invasively-assessed-by-laser-doppler-with-local-thermal-hyperemia-a-systematic-review-with-meta-analysis
#4
REVIEW
Dagmar Fuchs, Pepijn P Dupon, Laura A Schaap, Richard Draijer
BACKGROUND/INTRODUCTION: Diabetes and cardiovascular disease develop in concert with metabolic abnormalities mirroring and causing changes in the vasculature, particularly the microcirculation. The microcirculation can be affected in different parts of the body of which the skin is the most easily accessible tissue. PURPOSE: The association between diabetes and dermal microvascular dysfunction has been investigated in observational studies. However, the strength of the association is unknown...
January 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28089920/g-protein-coupled-estrogen-receptor-mediated-non-genomic-facilitatory-effect-of-estrogen-on-cooling-induced-reduction-of-skin-blood-flow-in-mice
#5
Izumi Serizawa, Nozomi Iwasaki, Hirotake Ishida, Shin-Ya Saito, Tomohisa Ishikawa
An enhanced vasoconstrictor activity of cutaneous arteries participates in the reduction of skin blood flow induced by cooling stimulation. Raynaud's phenomenon, which is characterized by intense cooling-induced constriction of cutaneous arteries, is more common in women during the period from menarche to menopause. We thus investigated the effect of 17β-estradiol (E2) on cooling-induced reduction of plantar skin blood flow (PSBF) in mouse in vivo. Ovariectomized female ddY mice, anaesthetized with pentobarbital, were treated with tetrodotoxin for eliminating the sympathetic nerve tone and artificially ventilated...
January 13, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28079680/middle-ear-sound-transmission-under-normal-damaged-repaired-and-reconstructed-conditions
#6
Wei Dong, Ying Tian, Xin Gao, Timothy T K Jung
HYPOTHESIS: We hypothesize that current clinical treatment strategies for the disarticulated or eroded incus have the effect of combining the incus and stapes of the human middle ear (ME) into one rigid structure, which, while capable of adequately transmitting lower-frequency sounds, fails for higher frequencies. BACKGROUND: ME damage causes conductive hearing loss (CHL) and while great progress has been made in repairing or reconstructing damaged MEs, the outcomes are often far from ideal...
January 10, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28079524/spatial-heterogeneity-in-the-time-and-frequency-properties-of-skin-perfusion
#7
Michele Sorelli, Zlatka Stoyneva, Irina Mizeva, Leonardo Bocchi
Pathological alterations of the microcirculatory system can be identified by measuring the temporal and spectral properties of Laser Doppler Flowmetry (LDF) signals acquired on the skin, and their changes following physiological stimulation. A wide range of stimulation protocols and measurement locations are observed in literature. Researchers often use non-invasive stimulation techniques, such as post-occlusive hyperaemia, cold tests, and local heating. As concerns the stimulation/recording sites, the forearm, fingers, and toes are typically selected to conduct microcirculation studies...
January 12, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28071840/%C3%AE-adrenergic-blockade-does-not-impair-the-skin-blood-flow-sensitivity-to-local-heating-in-burned-and-non-burned-skin-under-neutral-and-hot-environments-in-children
#8
Eric Rivas, Serina J McEntire, David N Herndon, Ronald P Mlcak, Oscar E Suman
OBJECTIVE: Tested the hypothesis that propranolol, a drug given to burn patients to reduce hypermetabolism/cardiac stress, may inhibit heat dissipation by changing the sensitivity of skin blood flow (SkBF) to local heating under neutral and hot conditions. METHODS: In a randomized double-blind study, a placebo was given to 8 burned children while propranolol was given to 13 burned children with similar characteristics (mean ±SD: 11.9±3y, 147±20cm, 45±23kg, 56±12% TBSA)...
January 10, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28065673/spectral-analysis-of-reflex-cutaneous-vasodilatation-during-passive-heat-stress
#9
Matthew M Mallette, Gary J Hodges, Gregory W McGarr, David A Gabriel, Stephen S Cheung
Previous work has demonstrated that spectral analysis is a useful tool to non-invasively ascertain the mechanisms of control of the cutaneous circulation. The majority of work using spectral analysis has focused on local control mechanisms, with none examining reflex control. Skin blood flow was analysed using spectral analysis on the dorsal aspect of the forearm of 7 males and 7 females during passive heat stress, with mean forearm and local temperature at the site of measurement maintained at thermoneutral (33°C) to minimize the effect of local control mechanisms...
January 5, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28060875/correlations-of-neck-shoulder-perfusion-characteristics-and-pain-symptoms-of-the-female-office-workers-with-sedentary-lifestyle
#10
Jian-Guo Bau, Taipau Chia, Shan-Hua Wei, Yung-Hui Li, Fun-Chie Kuo
AIM: Modern office workers are often impacted by chronic neck/shoulder pain. Most of the previous studies which investigated the relationship of the occupational factors and musculoskeletal symptoms had adopted questionnaire survey. In this study the microcirculatory characteristics and perceived symptoms in neck/shoulder region were compared among office workers with sedentary lifestyle. METHODS: Thirty-seven female office workers were recruited in this study. Microcirculatory flow in neck/shoulder region characterized by the mean blood flow (MMBF value), pulsatile blood flow (PMBF value), and the PMBF/MMBF ratio (perfusion pulsatility, PP) were investigated using Laser Doppler Flowmetry (LDF)...
2017: PloS One
https://www.readbyqxmd.com/read/28059556/effects-of-genital-response-measurement-device-and-stimulus-characteristics-on-sexual-concordance-in-women
#11
Katrina N Bouchard, Meredith L Chivers, Caroline F Pukall
Investigations of sexual concordance suggest that, on average, women exhibit a low, positive correlation between their subjective sexual arousal and genital response. However, this relationship appears to be stronger, on average, when genital response is measured via the external tissues of the vulva than within the vagina walls. Given the methodological variations, such as stimulus content and duration, in studies of vulvar and vaginal concordance, direct comparisons between individual studies are limited...
January 6, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28059297/absolute-distance-measurement-system-with-micron-grade-measurement-uncertainty-and-24-m-range-using-frequency-scanning-interferometry-with-compensation-of-environmental-vibration
#12
Cheng Lu, Guodong Liu, Bingguo Liu, Fengdong Chen, Yu Gan
We establish a theoretical model of the Doppler effect in absolute distance measurements using frequency scanning interferometry (FSI) and propose a novel FSI absolute distance measurement system. This system incorporates a basic FSI system and a laser Doppler velocimeter (LDV). The LDV results are used to correct for the Doppler effect in the absolute distance measurement signal obtained by the basic FSI system. In the measurement of a target located at 16 m, a measurement resolution of 65.5 μm is obtained, which is close to the theoretical resolution, and a standard deviation of 3...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28059254/nonmechanical-scanning-laser-doppler-velocimetry-for-distribution-measurements-of-two-dimensional-velocity-vectors-based-on-optical-quadrature-detection
#13
Koichi Maru
This paper proposes a nonmechanical scanning laser Doppler velocimeter (LDV) for measuring the distribution of two-dimensional velocity vectors. In the proposed LDV, an optical quadrature detection technique and a nonmechanical axial scanning technique are introduced into a reference-type LDV. Consequently, the LDV has a simple optical system without multiple light sources or frequency shifting and does not have any moving mechanisms in the probe. The experimental results obtained using a sensor probe setup indicate that the function of measuring two-dimensional velocity vectors and the scanning function are successfully demonstrated...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28043699/effect-of-phosphate-buffer-on-aggregation-kinetics-of-citrate-coated-silver-nanoparticles-induced-by-monovalent-and-divalent-electrolytes
#14
K Afshinnia, M Baalousha
The attachment efficiency (α) is an important parameter that can be used to characterize nanoparticle (NPs) aggregation behavior and has been a topic of discussion of several papers in the past few years. The importance of α is because it is one of the key parameters that can be used to model NP environmental fate and behavior. This study uses UV-vis and laser Doppler electrophoresis to monitor the aggregation behavior of citrate-coated silver nanoparticles (cit-AgNPs) induced by Na(+) and Ca(2+) as counter ions in the presence and absence of Suwannee River fulvic acid (SRFA) as a surrogate of natural organic matter and different concentrations of phosphate buffer (0-1mM)...
December 30, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28034564/acute-black-tea-consumption-improves-cutaneous-vascular-function-in-healthy-middle-aged-humans
#15
Kirsty A Woodward, Nicola D Hopkins, Richard Draijer, Young de Graaf, David A Low, Dick H J Thijssen
BACKGROUND & AIMS: Dietary flavonoids, such as those present in black tea, are associated with reduced risk of cardiovascular disease (CVD), possibly through improving nitric oxide (NO) mediated vascular function. The aim of this study was to examine the effect of acute black tea ingestion on cutaneous microvascular function. METHODS: Twenty healthy participants (58 ± 5 y, 9 men) attended two experimental trials (tea, placebo), 7-days apart in a randomised, controlled, double-blind, cross-over design...
December 22, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28033625/-analysis-of-critically-perfused-tissues-by-laser-speckle-contrast-analysis-lasca-perfusion-imaging
#16
A Limbourg, C Radtke, R Ipaktchi, P M Vogt
Background: The success of tissue transplantation and long-term tissue stability after wound healing depends on sufficient tissue perfusion. Laser Doppler-supported procedures allow for an objective measurement of relative tissue perfusion. The development of Speckle-based Laser Doppler imaging now enables a real-time representation of tissue perfusion. The perfusion of tissues relevant in plastic surgery such as scars, phalangeal replantations and burn wounds were systematically analysed by Laser Speckle Contrast Analysis (LASCA) imaging...
December 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28033183/investigation-of-osteoinductive-effects-of-different-compositions-of-bioactive-glass-nanoparticles-for-bone-tissue-engineering
#17
AmirHossein Tavakolizadeh, Mehdi Ahmadian, MohammadHossein Fathi, Ali Doostmohammadi, Ehsan Seyedjafari, Abdolreza Ardeshirylajimi
Bioactive glasses (BG) is one of the well-known materials that used as dental and bone implants, for this reason it is always interesting for researchers has been to increase BG efficiency in the bone tissue engineering. The aim of this work was to evaluate the osteoinductivity of BG different composition nanoparticles with SiO2-CaO-P2O5. The 45S, 58S, and 63S compositions were prepared via the sol-gel technique. Characterization techniques such as X-ray diffraction, field emission scanning electron microscopy (FE-SEM), and laser Doppler electrophoresis (LDE) were used...
December 26, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28031354/intra-arterial-nitroglycerin-as-directed-acute-treatment-in-experimental-ischemic-stroke
#18
Michael E Maniskas, Jill M Roberts, Rebecca Trueman, Annastazia E Learoyd, Amanda Gorman, Justin F Fraser, Gregory J Bix
BACKGROUND: Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke. The completed Efficacy of Nitric Oxide in Stroke trial suggested that GTN has therapeutic benefit with acute (within 6 hours) transdermal systemic sustained release therapy. OBJECTIVE: To examine an alternative use of GTN as an acute therapy for ischemic stroke following successful recanalization...
December 28, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28027937/reduced-perfusion-in-systemic-sclerosis-digital-ulcers-both-fingertip-and-extensor-can-be-increased-by-topical-application-of-glyceryl-trinitrate
#19
M Hughes, T Moore, J Manning, J Wilkinson, G Dinsdale, C Roberts, A Murray, A L Herrick
OBJECTIVES: In patients with systemic sclerosis (SSc), fingertip digital ulcers (DUs) are believed to be ischaemic, and extensor surface DUs a result of mechanical factors/microtrauma. Our aim was to assess blood flow response to topical glyceryl trinitrate (GTN) compared to placebo in SSc DUs, looking for differences in pathophysiology between fingertip and extensor lesions. METHOD: This was a double-blind, randomised, crossover, placebo-controlled study. Sixteen (6 fingertip, 10 extensor) DUs were each studied twice (one day apart): once with GTN and once with placebo ointment...
December 24, 2016: Microvascular Research
https://www.readbyqxmd.com/read/28027930/tocilizumab-improves-the-proatherothrombotic-profile-of-rheumatoid-arthritis-patients-modulating-endothelial-dysfunction-netosis-and-inflammation
#20
P Ruiz-Limón, R Ortega, I Arias de la Rosa, M C Abalos-Aguilera, C Perez Sanchez, Y Jimenez Gomez, E Peralbo-Santaella, P Font, D Ruiz-Vilches, G Ferrin, E Collantes-Estevez, A Escudero, C H López Pedrera, N Barbarroja
Tocilizumab (TCZ) is an effective treatment for rheumatoid arthritis (RA). However, the changes that occurred after TCZ therapy on endothelial dysfunction, monocyte activity, NETosis, and oxidative stress, the principal effectors of atherosclerosis and cardiovascular disease, have not been analyzed yet. A total of 20 RA patients received 162 mg per week subcutaneous TCZ for 6 months. Endothelial function was measured through postocclusive hyperemia using Laser Doppler. Oxidative stress markers in monocytes and neutrophils were analyzed by flow cytometry...
December 9, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
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