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https://www.readbyqxmd.com/read/29132765/cortical-thinning-correlates-of-changes-in-visuospatial-and-visuoperceptual-performance-in-parkinson-s-disease-a-4-year-follow-up
#1
A I Garcia-Diaz, B Segura, H C Baggio, C Uribe, A Campabadal, A Abos, M J Marti, F Valldeoriola, Y Compta, N Bargallo, C Junque
BACKGROUND: Growing evidence highlights the relevance of posterior cortically-based cognitive deficits in Parkinson's disease (PD) as possible biomarkers of the evolution to dementia. Cross-sectional correlational studies have established a relationship between the degree of atrophy in posterior brain regions and visuospatial and visuoperceptual (VS/VP) impairment. The aim of this study is to address the progressive cortical thinning correlates of VS/VP performance in PD. METHODS: Forty-four PD patients and 20 matched healthy subjects were included in this study and followed for 4 years...
November 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29100980/the-limbic-and-neocortical-contribution-of-%C3%AE-synuclein-tau-and-%C3%AE-amyloid-to-disease-duration-in-dementia-with-lewy-bodies
#2
Tanis J Ferman, Naoya Aoki, Julia E Crook, Melissa E Murray, Neill R Graff-Radford, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Jonathan Graff-Radford, Otto Pedraza, Kejal Kantarci, Bradley F Boeve, Dennis W Dickson
INTRODUCTION: We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and β-amyloid to duration of illness in dementia with Lewy bodies (DLB). METHODS: Quantitative digital pathology of neocortical and limbic α-synuclein, tau, and β-amyloid was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration...
October 31, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29096546/memory-keeper-a-prototype-digital-application-to-improve-engagement-with-people-with-dementia-in-long-term-care-innovative-practice
#3
Margaret McAllister, Jeanne Dayton, Florin Oprescu, Mary Katsikitis, Christian M Jones
People with dementia living in long-term care commonly experience loneliness and lack of meaningful activity. Memory Keeper is a prototype digital application that presents personalised prompts to stimulate reminiscences and meaningful engagement with formal and informal carers. A trial involving three persons with dementia in long-term care and seven family and staff members revealed no negative responses to the device or application. Family members said it was valuable in improving the quality of engagement and made visits more enjoyable...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29084321/frailty-phenotype-and-neuropsychological-test-performance-a-preliminary-analysis
#4
Terrie B Ginsberg, Leonard Powell, Arif Patel, Sheina Emrani, Anita Chopra, Thomas Cavalieri, David J Libon
Context: Frailty is a common problem that affects adults older than 65 years. Correlations between the frailty phenotype and neuropsychological impairment have not been thoroughly researched. Objective: To examine the association between frailty phenotype, neuropsychological screening test results, and neuropsychological domains known to characterize patients with mild cognitive impairment and dementia. Methods: This retrospective medical record analysis consisted of ambulatory patients aged 65 years or older seen in an outpatient geriatric practice...
November 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29070027/absolute-and-relative-reliability-of-acute-effects-of-aerobic-exercise-on-executive-function-in-seniors
#5
Lars Donath, Sebastian Ludyga, Daniel Hammes, Anja Rossmeissl, Nadin Andergassen, Lukas Zahner, Oliver Faude
BACKGROUND: Aging is accompanied by a decline of executive function. Aerobic exercise training induces moderate improvements of cognitive domains (i.e., attention, processing, executive function, memory) in seniors. Most conclusive data are obtained from studies with dementia or cognitive impairment. Confident detection of exercise training effects requires adequate between-day reliability and low day-to-day variability obtained from acute studies, respectively. These absolute and relative reliability measures have not yet been examined for a single aerobic training session in seniors...
October 25, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29067331/inferior-parietal-transcranial-direct-current-stimulation-with-training-improves-cognition-in-anomic-alzheimer-s-disease-and-frontotemporal-dementia
#6
Carlos Roncero, Heike Kniefel, Erik Service, Alexander Thiel, Stephan Probst, Howard Chertkow
INTRODUCTION: We evaluated whether transcranial direct current stimulation (tDCS) can improve picture-naming abilities in subjects with anomic Alzheimer or frontotemporal dementias. METHODS: Using a double-blind crossover design, 10 participants were trained on picture naming over a series of 10 sessions with either 30 minutes of anodal (2 mA) tDCS stimulation to the left inferior parieto-temporal region (P3) or sham stimulation. We evaluated performance on a trained picture-naming list, an equivalent untrained list, and additional neuropsychological tasks...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29065116/serum-igf-1-is-associated-with-cognitive-functions-in-early-drug-na%C3%A3-ve-parkinson-s-disease
#7
Marina Picillo, Rosario Pivonello, Gabriella Santangelo, Claudia Pivonello, Riccardo Savastano, Renata Auriemma, Marianna Amboni, Sara Scannapieco, Angela Pierro, Annamaria Colao, Paolo Barone, Maria Teresa Pellecchia
OBJECTIVE: Cognitive deficits are common in Parkinson's disease (PD) since the early stages and many patients eventually develop dementia. Yet, occurrence of dementia in PD is unpredictable. Evidence supports the hypothesis that insulin-like growth factor-1 (IGF-1) is involved in cognitive deficits. Our aim was to evaluate the relationship between serum IGF-1 levels and neuropsychological scores in a large cohort of drug-naïve PD patients during the earliest stages of the disease. METHODS: Serum IGF-1 levels were determined in 405 early, drug-naïve PD patients and 191 healthy controls (HC) enrolled in the Parkinson's Progression Markers Initiative (PPMI)...
2017: PloS One
https://www.readbyqxmd.com/read/29036819/age-and-graphomotor-decision-making-assessed-with-the-digital-clock-drawing-test-the-framingham-heart-study
#8
Ryan J Piers, Kathryn N Devlin, Boting Ning, Yulin Liu, Ben Wasserman, Joseph M Massaro, Melissa Lamar, Catherine C Price, Rod Swenson, Randall Davis, Dana L Penney, Rhoda Au, David J Libon
BACKGROUND: Digital Clock Drawing Test (dCDT) technology enables the examination of detailed neurocognitive behavior as behavior unfolds in in real time; a capability that cannot be obtained using a traditional pen and paper testing format. OBJECTIVE: Parameters obtained from the dCDT were used to investigate neurocognitive constructs related to higher-order neurocognitive decision-making and information processing speed. The current research sought to determine the effect of age as related to combined motor and non-motor components of drawing, and higher-order, decision-making latencies...
October 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29023452/functional-imaging-of-cognition-in-an-old-old-population-a-case-for-portable-functional-near-infrared-spectroscopy
#9
Theodore J Huppert, Helmet Karim, Chia-Cheng Lin, Bader A Alqahtani, Susan L Greenspan, Patrick J Sparto
In this study, functional near-infrared spectroscopy (fNIRS) was used to record brain activation during cognitive testing in older individuals (88±6yo; N = 19) living in residential care communities. This population, which is often associated with loss of personal independence due to physical or cognitive decline associated with aging, is also often under-represented in neuroscience research because of a limited means to participate in studies which often take place in large urban or university centers. In this study, we demonstrate the feasibility and initial results using a portable 8-source by 4-detector fNIRS system to measure brain activity from participants within residential care community centers...
2017: PloS One
https://www.readbyqxmd.com/read/28973176/association-between-poor-cognitive-functioning-and-risk-of-incident-parkinsonism-the-rotterdam-study
#10
Sirwan K L Darweesh, Frank J Wolters, Ronald B Postuma, Bruno H Stricker, Albert Hofman, Peter J Koudstaal, M Kamran Ikram, M Arfan Ikram
Importance: Cognitive dysfunction is a common feature among patients with parkinsonism, including Parkinson disease (PD). However, there is a scarcity of data on cognitive functioning before parkinsonism diagnosis, a stage at which patients may still respond to putative disease-modifying interventions. Objective: To assess whether poor cognitive functioning is associated with an increased risk of parkinsonism. Design, Setting, and Participants: Between January 8, 2002, and December 14, 2008, baseline cognitive function was assessed in 7386 participants of the Rotterdam Study who were free of parkinsonism and dementia...
September 25, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28961688/the-use-of-short-versions-of-the-japanese-wais-iii-to-aid-in-differentiation-between-alzheimer-s-disease-and-dementia-with-lewy-bodies
#11
Kazumi Ota, Eizo Iseki, Norio Murayama, Kiyoshi Sato, Heii Arai
Objective: We examined the cognitive characteristics of patients with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) using the Wechsler Adult Intelligent Scale-Third Edition (WAIS-III). In addition, the utility of short versions of WAIS-III for estimating IQ scores and index scores were examined. Methods: The subjects were 83 patients with probable AD, 33 patients with probable DLB, and 83 cognitively normal individuals. Results: Patients with DLB showed significantly lower scores in Performance IQ and Processing Speed compared with those with AD...
August 31, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28934192/metabolomics-and-cognition-in-african-american-adults-in-midlife-the-atherosclerosis-risk-in-communities-study
#12
J Bressler, B Yu, T H Mosley, D S Knopman, R F Gottesman, A Alonso, A R Sharrett, L M Wruck, E Boerwinkle
Clinical studies have shown alterations in metabolic profiles when patients with mild cognitive impairment and Alzheimer's disease dementia were compared to cognitively normal subjects. Associations between 204 serum metabolites measured at baseline (1987-1989) and cognitive change were investigated in 1035 middle-aged community-dwelling African American participants in the biracial Atherosclerosis Risk in Communities (ARIC) Study. Cognition was evaluated using the Delayed Word Recall Test (DWRT; verbal memory), the Digit Symbol Substitution Test (DSST; processing speed) and the Word Fluency Test (WFT; verbal fluency) at visits 2 (1990-1992) and 4 (1996-1998)...
July 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28921611/dendritic-spines-provide-cognitive-resilience-against-alzheimer-s-disease
#13
Benjamin D Boros, Kelsey M Greathouse, Erik G Gentry, Kendall A Curtis, Elizabeth L Birchall, Marla Gearing, Jeremy H Herskowitz
OBJECTIVE: Neuroimaging and other biomarker assays suggest that the pathological processes of Alzheimer's disease (AD) begin years prior to clinical dementia onset. However, some 30 to 50% of older individuals who harbor AD pathology do not become symptomatic in their lifetime. It is hypothesized that such individuals exhibit cognitive resilience that protects against AD dementia. We hypothesized that in cases with AD pathology, structural changes in dendritic spines would distinguish individuals who had or did not have clinical dementia...
October 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28876361/the-five-digits-test-in-the-assessment-of-older-adults-with-low-formal-education-construct-validity-and-reliability-in-a-brazilian-clinical-sample
#14
Jonas Jardim de Paula, Thaís Dell'Oro Oliveira, Emanuel Henrique Gonçalves Querino, Leandro Fernandes Malloy-Diniz
INTRODUCTION: In the assessment of older adults with very low formal education, typical tests of selective attention and inhibitory control are biased by reading abilities. In this sense, we aim to assess the psychometric characteristics of the Five Digits Test (FDT), a numerical Stroop paradigm, in older adults without cognitive disorders, with mild cognitive impairment, and with dementia. METHODS: We assessed 211 Brazilian older adults with low formal education using the FDT and other cognitive measures...
July 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28873856/development-testing-of-a-monitoring-system-assisting-mci-patients-the-european-project-inlife
#15
Evangelos Kaimakamis, Vaia Karavidopoulou, Vassilios Kilintzis, Leandros Stefanopoulos, Valentini Papageorgiou
INLIFE is a project cofounded from the European Union aiming in prolonging independent living of elderly people with cognitive impairment based on open, seamless ICT services supporting communication, daily activities, providing health services and professional care to the elderly. The main innovation stems from ICT solutions offering 19 different services adapted on specific characteristics elderly people with mild cognitive impairment, early and later stages of Dementia, cognitive impairment and co-morbid condition, as well as their formal and informal caregivers...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28873772/home-testing-of-a-digital-prompter-for-people-with-dementia
#16
Hazel Boyd, Nina Evans, Richard Cheston, Krist Noonan, Nigel Harris
This technology evaluation study assessed a personalised digital prompter designed for people with dementia, by trialling its use in the home by people with dementia and their carers. Technology based prompting may be used to support people with dementia to complete multi-step tasks in the home, provided that suitable tasks can be chosen and that a carer is able to load appropriate task steps onto the prompter. A prompter was developed specifically for this purpose, along with a detailed guidance manual. Twelve participants with mild or moderate dementia carried out cognitive tests and their carers completed carer burden and carer competence scales...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28855392/neuropathology-of-white-matter-lesions-blood-brain-barrier-dysfunction-and-dementia
#17
Atticus H Hainsworth, Thais Minett, Joycelyn Andoh, Gillian Forster, Ishaan Bhide, Thomas R Barrick, Kay Elderfield, Jamuna Jeevahan, Hugh S Markus, Leslie R Bridges
BACKGROUND AND PURPOSE: We tested whether blood-brain barrier dysfunction in subcortical white matter is associated with white matter abnormalities or risk of clinical dementia in older people (n=126; mean age 86.4, SD: 7.7 years) in the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study). METHODS: Using digital pathology, we quantified blood-brain barrier dysfunction (defined by immunohistochemical labeling for the plasma marker fibrinogen)...
October 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28855146/categorizing-health-outcomes-and-efficacy-of-mhealth-apps-for-persons-with-cognitive-impairment-a-systematic-review
#18
REVIEW
Daniel R Bateman, Bhavana Srinivas, Thomas W Emmett, Titus K Schleyer, Richard J Holden, Hugh C Hendrie, Christopher M Callahan
BACKGROUND: Use of mobile health (mHealth) apps is growing at an exponential rate in the United States and around the world. Mild cognitive impairment (MCI), Alzheimer disease, and related dementias are a global health problem. Numerous mHealth interventions exist for this population, yet the effect of these interventions on health has not been systematically described. OBJECTIVE: The aim of this study is to catalog the types of health outcomes used to measure effectiveness of mHealth interventions and assess which mHealth interventions have been shown to improve the health of persons with MCI, Alzheimer disease, and dementia...
August 30, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28844148/the-association-of-apolipoprotein-e-gene-polymorphism-with-cognitive-performance-in-nondemented-polish-adults-aged-55-to-75
#19
Małgorzata T Piskunowicz, Katarzyna Linkowska, Szymon Gołota, Tomasz Grzybowski, Kornelia Kędziora-Kornatowska, Alina Borkowska
The ε4 allele of the apolipoprotein E (APOE) gene is known as a risk factor for dementia. How APOE ε polymorphism affects cognitive performance in nondemented aging subjects remains less clear. In this study, the relationship between APOE status and cognitive performance across various cognitive domains in adults aged 55 to 75 years ( n = 74) without dementia was investigated. E4 carriers ( n = 11) performed worse versus noncarriers on forward Digit Span and delayed recall of the Rey-Osterrieth complex figure...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28817745/association-of-vision-loss-with-cognition-in-older-adults
#20
Stephanie P Chen, Jay Bhattacharya, Suzann Pershing
Importance: Visual dysfunction and poor cognition are highly prevalent among older adults; however, the relationship is not well defined. Objective: To evaluate the association of measured and self-reported visual impairment (VI) with cognition in older US adults. Design, Setting, and Participants: Cross-sectional analysis of 2 national data sets: the National Health and Nutrition Examination Survey (NHANES), 1999-2002, and the National Health and Aging Trends Study (NHATS), 2011-2015...
September 1, 2017: JAMA Ophthalmology
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