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https://www.readbyqxmd.com/read/27882654/digital-technologies-as-truth-bearers-in-health-care
#1
Ruth Bartlett, Andrew Balmer, Petula Brannelly
In this study, we explore the idea of digital technologies as truth-bearers in health care and argue that devices like SenseCam, which facilitate reflection and memory recall, have a potentially vital role in healthcare situations when questions of veracity are at stake (e.g., when best interest decisions are being made). We discuss the role of digital technologies as truth-bearers in the context of nursing people with dementia, as this is one area of health care in which the topic of truth-telling has been hotly debated...
November 23, 2016: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/27878426/the-differential-effects-of-alzheimer-s-disease-and-lewy-body-pathology-on-cognitive-performance-a-meta-analysis
#2
REVIEW
Ashita S Gurnani, Brandon E Gavett
Differential diagnosis of Alzheimer's disease (AD) from normal aging and other dementia etiologies is imperative for disease specific treatment options and long-term care planning. Neuropathological confirmation is the gold standard for neurodegenerative disease diagnosis, yet most published studies examining the use of neuropsychological tests in the differential diagnosis of dementia rely upon clinical diagnostic outcomes. The present study undertook a meta-analytic review of the literature to identify cognitive tests and domains that allow for the differentiation of individuals with AD pathology from individuals with dementia with Lewy Bodies (DLB) pathology and pathology-free individuals...
November 22, 2016: Neuropsychology Review
https://www.readbyqxmd.com/read/27861718/effect-of-cognitively-stimulating-activities-on-symptom-management-of-delirium-superimposed-on-dementia-a-randomized-controlled-trial
#3
Ann Kolanowski, Donna Fick, Mark Litaker, Paula Mulhall, Linda Clare, Nikki Hill, Jacqueline Mogle, Malaz Boustani, David Gill, Andrea Yevchak-Sillner
OBJECTIVE: To determine whether cognitively stimulating activities would reduce duration and severity of delirium and improve cognitive and physical function to a greater extent than usual care. DESIGN: Single-blind randomized clinical trial. SETTING: Eight post-acute care (PAC) facilities. PARTICIPANTS: Community-dwelling older adults with dementia and delirium (N = 283). INTERVENTION: Research staff provided cognitively stimulating activities daily for up to 30 days...
November 12, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27858717/diagnostic-value-of-a-tablet-based-drawing-task-for-discrimination-of-patients-in-the-early-course-of-alzheimer-s-disease-from-healthy-individuals
#4
Stephan Müller, Oliver Preische, Petra Heymann, Ulrich Elbing, Christoph Laske
There is a considerable delay in the diagnosis of dementia, which may reduce the effectiveness of available treatments. Thus, it is of great interest to develop fast and easy to perform, non-invasive and non-expensive diagnostic measures for the early detection of cognitive impairment and dementia. Here we investigate movement kinematics between 20 patients with early dementia due to Alzheimer's disease (eDAT), 30 patients with amnestic MCI (aMCI), and 20 cognitively healthy control (HC) individuals while copying a three-dimensional house using a digitizing tablet...
November 14, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27828876/improving-detection-of-hiv-associated-cognitive-impairment-comparison-of-the-international-hiv-dementia-scale-and-a-brief-screening-battery
#5
Sergio Monteiro de Almeida, Rujvi Kamat, Mariana Cherner, Anya Umlauf, Clea Elisa Ribeiro, Ana Paula de Pereira, Donald Franklin, Robert K Heaton, Ronald J Ellis
OBJECTIVES: The International HIV Dementia Scale (IHDS) was developed to screen for HIV-associated dementia (HAD), but it has been used more generally for HIV-associated neurocognitive disorder (HAND). This study sought to examine the accuracy of the IHDS in a cohort of Brazilian HIV-infected individuals and compare its performance to an alternative screening battery for detecting HAND. METHODS: 108 participants (including 60 HIV-infected persons), completed the IHDS and a gold standard neuropsychological (NP) battery of 17 tests...
November 4, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27807922/cognitive-performance-of-older-adults-in-a-specialized-diabetes-clinic
#6
Schimming Corbett, Luo Xiaodong, Zhang Cen, Sano Mary
BACKGROUND: Diabetes mellitus is a risk factor for cognitive changes, but assessment for cognitive disorders in this population is performed infrequently. This study examines the frequency of cognitive disorders and patterns of deficit in patients enrolled in a specialized clinic for diabetes. METHODS: A cross-sectional study was conducted to assess cognition in Mount Sinai Diabetes Center patients. Thirty eligible subjects age 50 or older were assessed and compared with non-diabetic cognitively normal control subjects, as well as non-diabetic subjects with Mild Cognitive Impairment (MCI)...
November 3, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27786168/computerized-respiratory-sound-analysis-in-people-with-dementia-a-first-step-towards-diagnosis-and-monitoring-of-respiratory-conditions
#7
Vânia Rocha, Cristina Melo, Alda Marques
Computerized respiratory sound analysis has been shown to be an objective and reliable way to assess respiratory diseases. However, its application in non-collaborative populations, such as people with dementia, is still unknown. Therefore this study aimed to characterize normal and adventitious respiratory sounds (NRS; ARS) in older people with and without dementia. A cross-sectional study including two groups of 30 subjects with dementia and 30 subjects without dementia was performed. Digital auscultation was used to record NRS and ARS per breathing-phase (inspiration/expiration) at trachea and thorax...
November 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27781389/genetic-variants-associated-with-risk-of-alzheimer-s-disease-contribute-to-cognitive-change-in-midlife-the-atherosclerosis-risk-in-communities-study
#8
Jan Bressler, Thomas H Mosley, Alan Penman, Rebecca F Gottesman, Beverly Gwen Windham, David S Knopman, Lisa M Wruck, Eric Boerwinkle
Alzheimer's disease (AD) is the most common form of dementia and is characterized by impairment in memory, behavioral changes, and gradual loss of autonomy. Since there is a long latent period prior to diagnosis, the aim of this study was to determine whether twenty single nucleotide polymorphisms identified in genome-wide association analyses of AD are associated with cognitive change in 8,320 white and 2,039 African-American middle-aged adults enrolled in the prospective Atherosclerosis Risk in Communities (ARIC) study...
October 26, 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/27780496/cognitive-and-anatomical-correlates-of-anosognosia-in-amnestic-mild-cognitive-impairment-and-early-stage-alzheimer-s-disease
#9
Gulben Senturk, Basar Bilgic, Ali Bilgin Arslan, Ali Bayram, Hasmet Hanagasi, Hakan Gurvit, Murat Emre
BACKGROUND: Anosognosia is a common feature in Alzheimer's disease (AD). The brain substrates of anosognosia are not fully understood, and less is known about the cognitive substrates of anosognosia in prodromal and early stages of AD. METHODS: Fourty-seven patients with amnestic-type mild cognitive impairment (aMCI) (n = 26) and early-stage AD (n = 21) were included, and Clinical Insight Rating Scale and Anosognosia Questionnaire for Dementia (AQ-D) were used to assess anosognosia...
October 26, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27723861/high-frequency-of-gba-gene-mutations-in-dementia-with-lewy-bodies-among-ashkenazi-jews
#10
Tamara Shiner, Anat Mirelman, Mali Gana Weisz, Anat Bar-Shira, Elissa Ash, Ron Cialic, Naomi Nevler, Tanya Gurevich, Noa Bregman, Avi Orr-Urtreger, Nir Giladi
Importance: Mutations in the glucocerebrosidase (GBA) gene are a risk factor for the development of dementia with Lewy bodies (DLB). These mutations are common among Ashkenazi Jews (AJ) and appear to have an effect on the natural history of the disease. Objectives: To evaluate the clinical and genetic characteristics of an AJ cohort of patients diagnosed with DLB, assess the association of phenotype of DLB with GBA mutations, and explore the effects of these mutations on the clinical course of the disease...
October 10, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27698556/digital-life-storybooks-for-people-with-dementia-living-in-care-homes-an-evaluation
#11
Ponnusamy Subramaniam, Bob Woods
BACKGROUND AND AIM: There is increasing interest in using information and communication technology to help older adults with dementia to engage in reminiscence work. Now, the feasibility of such approaches is beginning to be established. The purpose of this study was to establish an evidence-base for the acceptability and efficacy of using multimedia digital life storybooks with people with dementia in care homes, in comparison with conventional life storybooks, taking into account the perspectives of people with dementia, their relatives, and care staff...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27664357/-robotics-and-improvement-of-the-quality-of-geriatric-care
#12
Éric Ettore, Emeline Wyckaert, Renaud David, Philippe Robert, Olivier Guérin, Frédéric Prate
New technologies offer innovations to improve the care of the elderly with Alzheimer's or and other forms of dementia. Robots, endowed with features such as monitoring of physiological parameters, cognitive training or occupational therapy, have appeared. They are not, however, intended to replace humans. Still underutilized, these robots are in development, much like the digital literacy of the elderly.
September 2016: Soins. Gérontologie
https://www.readbyqxmd.com/read/27662310/cognitive-and-neuroanatomical-correlates-in-early-versus-late-onset-parkinson-s-disease-dementia
#13
Younggwang Kim, Dongkyun Lee, Kyoo Ho Cho, Jae Jung Lee, Jee Hyun Ham, Byoung Seok Ye, Seung-Koo Lee, Jong-Min Lee, Young H Sohn, Phil Hyu Lee
BACKGROUND: Aging is the most important risk factor of development of dementia in Parkinson's disease (PD), but there are no data on clinical and radiological heterogeneity of PD dementia (PDD) depending on age at onset. OBJECTIVES: The goal of this study was to examine whether patients with PDD are clinically and radiologically heterogeneous depending on age at onset. METHODS: A total of 116 patients with PD dementia and 121 age- and sex-matched normal controls were enrolled...
September 23, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27603384/increased-risk-of-cognitive-impairment-in-patients-with-components-of-metabolic-syndrome
#14
Chia-Kuang Tsai, Tung-Wei Kao, Jiunn-Tay Lee, Chen-Jung Wu, Dueng-Yuan Hueng, Chih-Sung Liang, Gia-Chi Wang, Fu-Chi Yang, Wei-Liang Chen
The number of old adults with cognitive impairment or dementia is anticipated to increase rapidly due to the aging population, especially the number of patients with multiple chronic conditions or metabolic perturbation. Metabolic syndrome (Mets) is among the most hazardous risk factors for cardiovascular disease and is linked to a chronic inflammatory disease. We investigated the National Health and Nutrition Examination Survey (NHANES) database for the years 1999 to 2002 to explore the connection between Mets and cognitive decline...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27598312/design-and-synthesis-of-potent-quinazolines-as-selective-%C3%AE-glucocerebrosidase-modulators
#15
Jianbin Zheng, Long Chen, Michael Schwake, Richard B Silverman, Dimitri Krainc
Gaucher's disease is a common genetic disease caused by mutations in the β-glucocerebrosidase (GBA1) gene that have been also linked to increased risk of Parkinson's disease and Lewy body dementia. Stabilization of misfolded mutant β-glucocerebrosidase (GCase) represents an important therapeutic strategy in synucleinopathies. Here we report a novel class of GCase quinazoline inhibitors, obtained in a high throughput screening, with moderate potency against wild-type GCase. Rational design and a SAR study of this class of compounds led to a new series of quinazoline derivatives with single-digit nanomolar potency...
September 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27583864/digit-symbol-substitution-test-score-and-hyperhomocysteinemia-in-older-adults
#16
Wen-Chuin Hsu, Yi-Chuan Chu, Hon-Chung Fung, Yau-Yau Wai, Jiun-Jie Wang, Jiann-Der Lee, Yi-Chun Chen
Mounting evidence shows that hyperhomocysteinemia is a risk factor for cognitive decline. This study enrolled subjects with normal serum levels of B12 and folate and performed thorough neuropsychological assessments to illuminate the independent role of homocysteine on cognitive functions.Participants between ages 50 and 85 were enrolled with Modified Hachinski ischemic score of <4, adequate visual and auditory acuity to allow neuropsychological testing, and good general health. Subjects with cognitive impairment resulting from secondary causes were excluded...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27567869/so-close-yet-so-far-executive-contribution-to-memory-processing-in-behavioral-variant-frontotemporal-dementia
#17
Maxime Bertoux, Siddharth Ramanan, Andrea Slachevsky, Stephanie Wong, Fernando Henriquez, Gada Musa, Carolina Delgado, Emma Flanagan, Michel Bottlaender, Marie Sarazin, Michael Hornberger, Bruno Dubois
BACKGROUND: Memory impairment in behavioral variant frontotemporal dementia (bvFTD) is traditionally considered to be mild and attributed to prefrontal cortex dysfunction. Recent studies, however, indicated that some patients can present with a memory impairment of the hippocampal type, showing storage and consolidation deficits in addition to the more executive/prefrontal related encoding and strategic difficulties. OBJECTIVE: This study aimed to study the relationship between executive functions (EF) and memory processes in bvFTD via a data-driven approach...
October 4, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27561149/paradoxical-trend-for-improvement-in-mental-health-with-aging-a-community-based-study-of-1-546-adults-aged-21-100-years
#18
Michael L Thomas, Christopher N Kaufmann, Barton W Palmer, Colin A Depp, Averria Sirkin Martin, Danielle K Glorioso, Wesley K Thompson, Dilip V Jeste
OBJECTIVE: Studies of aging usually focus on trajectories of physical and cognitive function, with far less emphasis on overall mental health, despite its impact on general health and mortality. This study examined linear and nonlinear trends of physical, cognitive, and mental health over the entire adult lifespan. METHODS: Cross-sectional data were obtained from 1,546 individuals aged 21-100 years, selected using random digit dialing for the Successful AGing Evaluation (SAGE) study, a structured multicohort investigation that included telephone interviews and in-home surveys of community-based adults without dementia...
August 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27536467/leptin-adiponectin-and-cognition-in-middle-aged-hiv-infected-and-uninfected-women-the-brooklyn-women-s-interagency-hiv-study
#19
Deborah R Gustafson, Michelle M Mielke, Sheila A Keating, Susan Holman, Howard Minkoff, Howard A Crystal
CONTEXT: Case-control study of women with and without HIV infection. OBJECTIVE: To explore the association of cognition and the adipokines, leptin and adiponectin (total; high molecular weight, HMW), in women with (HIV+) and without HIV (HIV-) infection. DESIGN: Cross-sectional analyses of adipokines and cognition using linear regression models of log-transformed adipokines, and Trails A, Trails B, Stroop interference time, Stroop word recall, Stroop color naming and reading, and Symbol Digit Modalities Test (SDMT) with consideration for age, HIV infection status, education, CD4 count, diabetes, body mass index (BMI), waist circumference (WC) and race/ethnicity...
October 2015: Journal of Gerontology & Geriatric Research
https://www.readbyqxmd.com/read/27534322/interaction-design-in-the-built-environment-designing-for-the-universal-user
#20
Cathy Dalton
Concepts of responsive architecture have to date largely involved response to environmental context, in order to mediate ambient environmental factors and modify internal conditions for the comfort of users, with energy efficiency and sustainability as the main impetus. 'Smart' buildings often address little other than technically functional issues, with any ideas of 'design' as a unifying factor being disregarded. At the same time, music and performance art have been in the vanguard of creating digital interaction that intimately involves the user in aesthetic outcomes, in the creation of what Umberto Eco describes as an 'Open Work'...
2016: Studies in Health Technology and Informatics
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