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https://www.readbyqxmd.com/read/29345144/pilot-randomized-controlled-trial-of-the-go-game-intervention-on-cognitive-function
#1
Ai Iizuka, Hiroyuki Suzuki, Susumu Ogawa, Kimi Estela Kobayashi-Cuya, Momoko Kobayashi, Toru Takebayashi, Yoshinori Fujiwara
This study investigated the effects of an intervention using the game "GO" on cognitive function in nursing home residents and evaluated the acquisition of GO according to each stage of dementia. Participants were randomly assigned to either the GO intervention group or a control group, and the intervention was performed once weekly for 15 weeks. Cognitive tests were conducted before and after intervention, and 17 participants were included in the final analysis. Analysis of covariance demonstrated that in the intervention group, the digit span total score significantly improved and the digit span backward score was maintained, whereas these scores decreased in the control group...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29324267/clinical-validity-of-the-japanese-version-of-wais-iii-short-forms-adaptation-for-patients-with-mild-neurocognitive-disorder-and-dementia
#2
Mihoko Takeda, Makoto Nakaya, Yoko Kikuchi, Sayaka Inoue, Tomoyuki Kamata
We investigated the Japanese WAIS-III short form utility in mild neurocognitive disorder and dementia. Our sample consisted of 108 old patients (ages: 65-89; mean age = 78.3). Fifteen short forms (SFs) and full-scale (FS) IQs were compared. The SFs included Dyads (SF1, SF2), Triads (SF3), Tetrads (SF4, SF5, SF6, SF7), Pentad (SF8), Six-subtest (SF9), Seven-subtests (SF10(a)(b), SF11(a)(b), SF12), and Nine-subtest (SF13). Correlations between SFIQs and FSIQ were all significant. Significant differences also were found in paired t-test between FSIQ and 5 SFIQs (SF2: t = -4...
December 29, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29238390/modulatory-effect-of-association-of-brain-stimulation-by-light-and-binaural-beats-in-specific-brain-waves
#3
Mauricio Rocha Calomeni, Vernon Furtado da Silva, Bruna Brandão Velasques, Olavo Guimarães Feijó, Juliana Marques Bittencourt, Alair Pedro Ribeiro de Souza E Silva
Introduction: One of the positive effects of brain stimulation is interhemispheric modulation as shown in some scientific studies. This study examined if a type of noninvasive stimulation using binaural beats with led-lights and sound would show different modulatory effects upon Alfa and SMR brain waves of elderlies and children with some disease types. Subjects: The sample included 75 individuals of both genders, being, randomly, divided in 6 groups. Groups were named elderly without dementia diagnosis (EWD), n=15, 76±8 years, elderly diagnosed with Parkinson's disease (EDP), n=15, 72±7 years, elderly diagnosed with Alzheimer's disease (EDA), n=15, 81±6 years...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29228211/asymmetry-of-post-mortem-neuropathology-in-behavioural-variant-frontotemporal-dementia
#4
David J Irwin, Corey T McMillan, Sharon X Xie, Katya Rascovsky, Vivianna M Van Deerlin, H Branch Coslett, Roy Hamilton, Geoffrey Aguirre, Edward B Lee, Virginia M Y Lee, John Q Trojanowski, Murray Grossman
Antemortem behavioural and anatomic abnormalities have largely been associated with right hemisphere disease in behavioural-variant frontotemporal dementia, but post-mortem neuropathological examination of bilateral hemispheres remains to be defined. Here we measured the severity of post-mortem pathology in both grey and white matter using a validated digital image analysis method in four cortical regions sampled from each hemisphere in 26 patients with behavioural-variant frontotemporal dementia, including those with frontotemporal degeneration (i...
December 8, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29200836/computerized-cognitive-stimulation-and-engagement-programs-in-older-adults-with-mild-cognitive-impairment-comparing-feasibility-acceptability-and-cognitive-and-psychosocial-effects
#5
Leila Djabelkhir, Ya-Huei Wu, Jean-Sébastien Vidal, Victoria Cristancho-Lacroix, Fabienne Marlats, Hermine Lenoir, Ariela Carno, Anne-Sophie Rigaud
Purpose: Mild cognitive impairment (MCI) is associated with a higher risk of dementia and is becoming a topic of interest for pharmacological and nonpharmacological interventions. With advances in technology, computer-based cognitive exercises are increasingly integrated into traditional cognitive interventions, such as cognitive training. Another type of cognitive intervention involving technology use is cognitive engagement, consisting of involving participants in highly motivational and mentally challenging activities, such as learning to use a form of new digital technology...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29197200/conscious-attention-defect-and-inhibitory-control-deficit-in-parkinson-s-disease-mild-cognitive-impairment-a-comparison-study-with-amnestic-mild-cognitive-impairment-multiple-domain
#6
Davide Maria Cammisuli, Marco Timpano Sportiello
BACKGROUND: Frontal/executive dysfunction commonly occurs in Parkinso's disease - Mild Cognitive Impairment (PD-MCI patients). However, to date, the number of studies comparing PD-MCI and MCI patients of other etiologies are too small. The present study aims at clarifying the attention/working memory and executive dysfunction of PD-MCI patients in comparison to amnestic MCI multiple domain patients with first extended then abbreviated structural brain changes suggesting preclinical Alzheimer's Disease...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29192511/the-kinect-project-group-motion-based-gaming-for-people-living-with-dementia
#7
Erica Dove, Arlene Astell
Engaging in enjoyable activities is an essential part of well-being, but people with dementia can find participation increasingly difficult. Motion-based technologies can provide meaningful engagement in a wide range of activities, but for people with dementia to take advantage of these devices requires a good understanding of how best to select and present these activities to this population. The objective of this study was to explore the use of motion-based technology (Xbox Kinect) as a group activity for people with dementia who attend adult day programmes...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29165082/easy-screening-for-mild-alzheimer-s-disease-and-mild-cognitive-impairment-from-elderly-speech
#8
Shohei Kato, Akira Homma, Takuto Sakuma
OBJECTIVE: This study presents a novel approach for early detection of cognitive impairment in the elderly. The approach incorporates the use of speech sound analysis, multivariate statistics, and data-mining techniques. We have developed a speech prosody-based cognitive impairment rating (SPCIR) that can distinguish between cognitively normal controls and elderly people with mild Alzheimer's disease (mAD) or mild cognitive impairment (MCI) using prosodic signals extracted from elderly speech while administering a questionnaire...
November 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29164314/cross-national-gender-variations-of-digit-ratio-2d-4d-correlate-with-life-expectancy-suicide-rate-and-other-causes-of-death
#9
Bernd Lenz, Johannes Kornhuber
The second-to-fourth finger length ratio (2D:4D) is an indication of prenatal sex hormone exposure, and has sex-specifically been associated with several lethal illnesses including ischemic heart disease, diverse cancers, and suicide. Our primary aim was to verify that 2D:4D sex-specifically relates to life expectancy and suicide numbers on a national level (23 countries). We also used a hypothesis-free approach to investigate associations with other causes of death [p value adjustment for multiple hypothesis testing using the false discovery rate procedure (FDR)]...
November 21, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29132765/cortical-thinning-correlates-of-changes-in-visuospatial-and-visuoperceptual-performance-in-parkinson-s-disease-a-4-year-follow-up
#10
A I Garcia-Diaz, B Segura, H C Baggio, C Uribe, A Campabadal, A Abos, M J Marti, F Valldeoriola, Y Compta, N Bargallo, C Junque
BACKGROUND: Growing evidence highlights the relevance of posterior cortically-based cognitive deficits in Parkinson's disease (PD) as possible biomarkers of the evolution to dementia. Cross-sectional correlational studies have established a relationship between the degree of atrophy in posterior brain regions and visuospatial and visuoperceptual (VS/VP) impairment. The aim of this study is to address the progressive cortical thinning correlates of VS/VP performance in PD. METHODS: Forty-four PD patients and 20 matched healthy subjects were included in this study and followed for 4 years...
November 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29100980/the-limbic-and-neocortical-contribution-of-%C3%AE-synuclein-tau-and-amyloid-%C3%AE-to-disease-duration-in-dementia-with-lewy-bodies
#11
Tanis J Ferman, Naoya Aoki, Julia E Crook, Melissa E Murray, Neill R Graff-Radford, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Jonathan Graff-Radford, Otto Pedraza, Kejal Kantarci, Bradley F Boeve, Dennis W Dickson
INTRODUCTION: We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and amyloid β (Aβ) to duration of illness in dementia with Lewy bodies (DLB). METHODS: Quantitative digital pathology of limbic and neocortical α-synuclein, tau, and Aβ was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration...
October 31, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29096546/memory-keeper-a-prototype-digital-application-to-improve-engagement-with-people-with-dementia-in-long-term-care-innovative-practice
#12
Margaret McAllister, Jeanne Dayton, Florin Oprescu, Mary Katsikitis, Christian M Jones
People with dementia living in long-term care commonly experience loneliness and lack of meaningful activity. Memory Keeper is a prototype digital application that presents personalised prompts to stimulate reminiscences and meaningful engagement with formal and informal carers. A trial involving three persons with dementia in long-term care and seven family and staff members revealed no negative responses to the device or application. Family members said it was valuable in improving the quality of engagement and made visits more enjoyable...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29084321/frailty-phenotype-and-neuropsychological-test-performance-a-preliminary-analysis
#13
Terrie B Ginsberg, Leonard Powell, Arif Patel, Sheina Emrani, Anita Chopra, Thomas Cavalieri, David J Libon
Context: Frailty is a common problem that affects adults older than 65 years. Correlations between the frailty phenotype and neuropsychological impairment have not been thoroughly researched. Objective: To examine the association between frailty phenotype, neuropsychological screening test results, and neuropsychological domains known to characterize patients with mild cognitive impairment and dementia. Methods: This retrospective medical record analysis consisted of ambulatory patients aged 65 years or older seen in an outpatient geriatric practice...
November 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29070027/absolute-and-relative-reliability-of-acute-effects-of-aerobic-exercise-on-executive-function-in-seniors
#14
Lars Donath, Sebastian Ludyga, Daniel Hammes, Anja Rossmeissl, Nadin Andergassen, Lukas Zahner, Oliver Faude
BACKGROUND: Aging is accompanied by a decline of executive function. Aerobic exercise training induces moderate improvements of cognitive domains (i.e., attention, processing, executive function, memory) in seniors. Most conclusive data are obtained from studies with dementia or cognitive impairment. Confident detection of exercise training effects requires adequate between-day reliability and low day-to-day variability obtained from acute studies, respectively. These absolute and relative reliability measures have not yet been examined for a single aerobic training session in seniors...
October 25, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29067331/inferior-parietal-transcranial-direct-current-stimulation-with-training-improves-cognition-in-anomic-alzheimer-s-disease-and-frontotemporal-dementia
#15
Carlos Roncero, Heike Kniefel, Erik Service, Alexander Thiel, Stephan Probst, Howard Chertkow
INTRODUCTION: We evaluated whether transcranial direct current stimulation (tDCS) can improve picture-naming abilities in subjects with anomic Alzheimer or frontotemporal dementias. METHODS: Using a double-blind crossover design, 10 participants were trained on picture naming over a series of 10 sessions with either 30 minutes of anodal (2 mA) tDCS stimulation to the left inferior parieto-temporal region (P3) or sham stimulation. We evaluated performance on a trained picture-naming list, an equivalent untrained list, and additional neuropsychological tasks...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29065116/serum-igf-1-is-associated-with-cognitive-functions-in-early-drug-na%C3%A3-ve-parkinson-s-disease
#16
Marina Picillo, Rosario Pivonello, Gabriella Santangelo, Claudia Pivonello, Riccardo Savastano, Renata Auriemma, Marianna Amboni, Sara Scannapieco, Angela Pierro, Annamaria Colao, Paolo Barone, Maria Teresa Pellecchia
OBJECTIVE: Cognitive deficits are common in Parkinson's disease (PD) since the early stages and many patients eventually develop dementia. Yet, occurrence of dementia in PD is unpredictable. Evidence supports the hypothesis that insulin-like growth factor-1 (IGF-1) is involved in cognitive deficits. Our aim was to evaluate the relationship between serum IGF-1 levels and neuropsychological scores in a large cohort of drug-naïve PD patients during the earliest stages of the disease. METHODS: Serum IGF-1 levels were determined in 405 early, drug-naïve PD patients and 191 healthy controls (HC) enrolled in the Parkinson's Progression Markers Initiative (PPMI)...
2017: PloS One
https://www.readbyqxmd.com/read/29036819/age-and-graphomotor-decision-making-assessed-with-the-digital-clock-drawing-test-the-framingham-heart-study
#17
Ryan J Piers, Kathryn N Devlin, Boting Ning, Yulin Liu, Ben Wasserman, Joseph M Massaro, Melissa Lamar, Catherine C Price, Rod Swenson, Randall Davis, Dana L Penney, Rhoda Au, David J Libon
BACKGROUND: Digital Clock Drawing Test (dCDT) technology enables the examination of detailed neurocognitive behavior as behavior unfolds in in real time; a capability that cannot be obtained using a traditional pen and paper testing format. OBJECTIVE: Parameters obtained from the dCDT were used to investigate neurocognitive constructs related to higher-order neurocognitive decision-making and information processing speed. The current research sought to determine the effect of age as related to combined motor and non-motor components of drawing, and higher-order, decision-making latencies...
October 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29023452/functional-imaging-of-cognition-in-an-old-old-population-a-case-for-portable-functional-near-infrared-spectroscopy
#18
Theodore J Huppert, Helmet Karim, Chia-Cheng Lin, Bader A Alqahtani, Susan L Greenspan, Patrick J Sparto
In this study, functional near-infrared spectroscopy (fNIRS) was used to record brain activation during cognitive testing in older individuals (88±6yo; N = 19) living in residential care communities. This population, which is often associated with loss of personal independence due to physical or cognitive decline associated with aging, is also often under-represented in neuroscience research because of a limited means to participate in studies which often take place in large urban or university centers. In this study, we demonstrate the feasibility and initial results using a portable 8-source by 4-detector fNIRS system to measure brain activity from participants within residential care community centers...
2017: PloS One
https://www.readbyqxmd.com/read/28973176/association-between-poor-cognitive-functioning-and-risk-of-incident-parkinsonism-the-rotterdam-study
#19
Sirwan K L Darweesh, Frank J Wolters, Ronald B Postuma, Bruno H Stricker, Albert Hofman, Peter J Koudstaal, M Kamran Ikram, M Arfan Ikram
Importance: Cognitive dysfunction is a common feature among patients with parkinsonism, including Parkinson disease (PD). However, there is a scarcity of data on cognitive functioning before parkinsonism diagnosis, a stage at which patients may still respond to putative disease-modifying interventions. Objective: To assess whether poor cognitive functioning is associated with an increased risk of parkinsonism. Design, Setting, and Participants: Between January 8, 2002, and December 14, 2008, baseline cognitive function was assessed in 7386 participants of the Rotterdam Study who were free of parkinsonism and dementia...
December 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28961688/the-use-of-short-versions-of-the-japanese-wais-iii-to-aid-in-differentiation-between-alzheimer-s-disease-and-dementia-with-lewy-bodies
#20
Kazumi Ota, Eizo Iseki, Norio Murayama, Kiyoshi Sato, Heii Arai
Objective: We examined the cognitive characteristics of patients with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) using the Wechsler Adult Intelligent Scale-Third Edition (WAIS-III). In addition, the utility of short versions of WAIS-III for estimating IQ scores and index scores were examined. Methods: The subjects were 83 patients with probable AD, 33 patients with probable DLB, and 83 cognitively normal individuals. Results: Patients with DLB showed significantly lower scores in Performance IQ and Processing Speed compared with those with AD...
August 31, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
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