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Digital dementia

Tamara Shiner, Anat Mirelman, Mali Gana Weisz, Anat Bar-Shira, Elissa Ash, Ron Cialic, Naomi Nevler, Tanya Gurevich, Noa Bregman, Avi Orr-Urtreger, Nir Giladi
Importance: Mutations in the glucocerebrosidase (GBA) gene are a risk factor for the development of dementia with Lewy bodies (DLB). These mutations are common among Ashkenazi Jews (AJ) and appear to have an effect on the natural history of the disease. Objectives: To evaluate the clinical and genetic characteristics of an AJ cohort of patients diagnosed with DLB, assess the association of phenotype of DLB with GBA mutations, and explore the effects of these mutations on the clinical course of the disease...
October 10, 2016: JAMA Neurology
Ponnusamy Subramaniam, Bob Woods
BACKGROUND AND AIM: There is increasing interest in using information and communication technology to help older adults with dementia to engage in reminiscence work. Now, the feasibility of such approaches is beginning to be established. The purpose of this study was to establish an evidence-base for the acceptability and efficacy of using multimedia digital life storybooks with people with dementia in care homes, in comparison with conventional life storybooks, taking into account the perspectives of people with dementia, their relatives, and care staff...
2016: Clinical Interventions in Aging
Éric Ettore, Emeline Wyckaert, Renaud David, Philippe Robert, Olivier Guérin, Frédéric Prate
New technologies offer innovations to improve the care of the elderly with Alzheimer's or and other forms of dementia. Robots, endowed with features such as monitoring of physiological parameters, cognitive training or occupational therapy, have appeared. They are not, however, intended to replace humans. Still underutilized, these robots are in development, much like the digital literacy of the elderly.
September 2016: Soins. Gérontologie
Younggwang Kim, Dongkyun Lee, Kyoo Ho Cho, Jae Jung Lee, Jee Hyun Ham, Byoung Seok Ye, Seung-Koo Lee, Jong-Min Lee, Young H Sohn, Phil Hyu Lee
BACKGROUND: Aging is the most important risk factor of development of dementia in Parkinson's disease (PD), but there are no data on clinical and radiological heterogeneity of PD dementia (PDD) depending on age at onset. OBJECTIVES: The goal of this study was to examine whether patients with PDD are clinically and radiologically heterogeneous depending on age at onset. METHODS: A total of 116 patients with PD dementia and 121 age- and sex-matched normal controls were enrolled...
September 23, 2016: Journal of Alzheimer's Disease: JAD
Chia-Kuang Tsai, Tung-Wei Kao, Jiunn-Tay Lee, Chen-Jung Wu, Dueng-Yuan Hueng, Chih-Sung Liang, Gia-Chi Wang, Fu-Chi Yang, Wei-Liang Chen
The number of old adults with cognitive impairment or dementia is anticipated to increase rapidly due to the aging population, especially the number of patients with multiple chronic conditions or metabolic perturbation. Metabolic syndrome (Mets) is among the most hazardous risk factors for cardiovascular disease and is linked to a chronic inflammatory disease. We investigated the National Health and Nutrition Examination Survey (NHANES) database for the years 1999 to 2002 to explore the connection between Mets and cognitive decline...
September 2016: Medicine (Baltimore)
Jianbin Zheng, Long Chen, Michael Schwake, Richard B Silverman, Dimitri Krainc
Gaucher's disease is a common genetic disease caused by mutations in the β-glucocerebrosidase (GBA1) gene that have been also linked to increased risk of Parkinson's disease and Lewy body dementia. Stabilization of misfolded mutant β-glucocerebrosidase (GCase) represents an important therapeutic strategy in synucleinopathies. Here we report a novel class of GCase quinazoline inhibitors, obtained in a high throughput screening, with moderate potency against wild-type GCase. Rational design and a SAR study of this class of compounds led to a new series of quinazoline derivatives with single-digit nanomolar potency...
September 22, 2016: Journal of Medicinal Chemistry
Wen-Chuin Hsu, Yi-Chuan Chu, Hon-Chung Fung, Yau-Yau Wai, Jiun-Jie Wang, Jiann-Der Lee, Yi-Chun Chen
Mounting evidence shows that hyperhomocysteinemia is a risk factor for cognitive decline. This study enrolled subjects with normal serum levels of B12 and folate and performed thorough neuropsychological assessments to illuminate the independent role of homocysteine on cognitive functions.Participants between ages 50 and 85 were enrolled with Modified Hachinski ischemic score of <4, adequate visual and auditory acuity to allow neuropsychological testing, and good general health. Subjects with cognitive impairment resulting from secondary causes were excluded...
August 2016: Medicine (Baltimore)
Maxime Bertoux, Siddharth Ramanan, Andrea Slachevsky, Stephanie Wong, Fernando Henriquez, Gada Musa, Carolina Delgado, Emma Flanagan, Michel Bottlaender, Marie Sarazin, Michael Hornberger, Bruno Dubois
BACKGROUND: Memory impairment in behavioral variant frontotemporal dementia (bvFTD) is traditionally considered to be mild and attributed to prefrontal cortex dysfunction. Recent studies, however, indicated that some patients can present with a memory impairment of the hippocampal type, showing storage and consolidation deficits in addition to the more executive/prefrontal related encoding and strategic difficulties. OBJECTIVE: This study aimed to study the relationship between executive functions (EF) and memory processes in bvFTD via a data-driven approach...
October 4, 2016: Journal of Alzheimer's Disease: JAD
Michael L Thomas, Christopher N Kaufmann, Barton W Palmer, Colin A Depp, Averria Sirkin Martin, Danielle K Glorioso, Wesley K Thompson, Dilip V Jeste
OBJECTIVE: Studies of aging usually focus on trajectories of physical and cognitive function, with far less emphasis on overall mental health, despite its impact on general health and mortality. This study examined linear and nonlinear trends of physical, cognitive, and mental health over the entire adult lifespan. METHODS: Cross-sectional data were obtained from 1,546 individuals aged 21-100 years, selected using random digit dialing for the Successful AGing Evaluation (SAGE) study, a structured multicohort investigation that included telephone interviews and in-home surveys of community-based adults without dementia...
August 2016: Journal of Clinical Psychiatry
Deborah R Gustafson, Michelle M Mielke, Sheila A Keating, Susan Holman, Howard Minkoff, Howard A Crystal
CONTEXT: Case-control study of women with and without HIV infection. OBJECTIVE: To explore the association of cognition and the adipokines, leptin and adiponectin (total; high molecular weight, HMW), in women with (HIV+) and without HIV (HIV-) infection. DESIGN: Cross-sectional analyses of adipokines and cognition using linear regression models of log-transformed adipokines, and Trails A, Trails B, Stroop interference time, Stroop word recall, Stroop color naming and reading, and Symbol Digit Modalities Test (SDMT) with consideration for age, HIV infection status, education, CD4 count, diabetes, body mass index (BMI), waist circumference (WC) and race/ethnicity...
October 2015: Journal of Gerontology & Geriatric Research
Cathy Dalton
Concepts of responsive architecture have to date largely involved response to environmental context, in order to mediate ambient environmental factors and modify internal conditions for the comfort of users, with energy efficiency and sustainability as the main impetus. 'Smart' buildings often address little other than technically functional issues, with any ideas of 'design' as a unifying factor being disregarded. At the same time, music and performance art have been in the vanguard of creating digital interaction that intimately involves the user in aesthetic outcomes, in the creation of what Umberto Eco describes as an 'Open Work'...
2016: Studies in Health Technology and Informatics
Lydia Bunker, Tammy T Hshieh, Bonnie Wong, Eva M Schmitt, Thomas Travison, Jacqueline Yee, Kerry Palihnich, Eran Metzger, Tamara G Fong, Sharon K Inouye
OBJECTIVE: Neuropsychological test batteries are administered in person to assess cognitive function in both clinical and research settings. However, in-person administration holds a number of logistical challenges that makes it difficult to use in large or remote populations or for multiple serial assessments over time. The purpose of this descriptive study was to determine whether a telephone-administered neuropsychological test battery correlated well with in-person testing. METHODS: Fifty English-speaking patients without dementia, over 70 years old, and part of a cohort of patients in a prospective cohort study examining cognitive outcomes following elective surgery were enrolled in this study...
August 9, 2016: International Journal of Geriatric Psychiatry
Derya Guner, Bedile Irem Tiftikcioglu, Nilgun Tuncay, Yasar Zorlu
Cognitive dysfunction can emerge during the clinical course of Parkinson's disease (PD) even beginning in early stages, which requires extended neuropsychological tests for diagnosis. There is need for rapid, feasible, and practical tests in clinical practice to diagnose and monitor the patients without causing any discomfort. We investigated the utility of quantitative analysis of digital EEG (qEEG) for diagnosing subtle cognitive impairment in PD patients without evident cognitive deficits (ie, "normal cognition")...
August 3, 2016: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
YanHong Dong, Zhong Jie Kua, Eric Yin Hao Khoo, Edward H Koo, Reshma A Merchant
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with an increased risk for mild cognitive impairment and dementia in both middle-aged and older individuals. Brief cognitive tests can potentially serve as a reliable and cost effective approach to detect for cognitive decrements in clinical practice. OBJECTIVE: This systematic review examined the utility of brief cognitive tests in studies with patients with T2DM. METHOD: This systematic review was conducted according to guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses...
October 1, 2016: Journal of the American Medical Directors Association
Bart Hattink, Rose-Marie Droes, Sietske Sikkes, Ellen Oostra, Afina W Lemstra
BACKGROUND: Dementia is a progressive and highly disabling neurodegenerative disease that will likely become highly prevalent in the future due to the globally aging population. To improve health care efficiency and quality for dementia care, eHealth could help with, for example, an online portal, such as the Digital Alzheimer Center (DAC) of the Vrije Universiteit Medical Center Amsterdam. It provides up-to-date disease information, peer-to-peer contact, and methods for contacting the hospital and health professionals...
2016: JMIR Research Protocols
Jessica J Weyerman, Cassidy Rose, Maria C Norton
OBJECTIVES: We determined the feasibility of accessing personal journals and correlating markers of linguistic complexity with all-cause dementia and Alzheimer's disease (AD). METHOD: A stratified random sample of 215 older adults reported on lifetime journal writing habits. From 66 of these participants (49% of those with journals), digital photographs of journal text were transcribed then subjected to the Linguistic Inquiry Word Count program to measure linguistic complexity markers: Words per Sentence, Percentage of 6+ Letter Words, Cognitive Mechanics, Percentage of Unique Words, and Percentage of Words that are Numerals...
July 8, 2016: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Elke Kalbe, Sarah Petra Rehberg, Ines Heber, Martin Kronenbuerger, Jörg B Schulz, Alexander Storch, Katharina Linse, Christine Schneider, Susanne Gräber, Inga Liepelt-Scarfone, Daniela Berg, Judith Dams, Monika Balzer-Geldsetzer, Rüdiger Hilker, Carola Oberschmidt, Karsten Witt, Nele Schmidt, Brit Mollenhauer, Claudia Trenkwalder, Annika Spottke, Sandra Roeske, Hans-Ulrich Wittchen, Oliver Riedel, Richard Dodel
OBJECTIVE: Inconsistent results exist regarding the cognitive profile in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). We aimed at providing data on this topic from a large cohort of patients with PD-MCI. METHODS: Sociodemographic, clinical and neuropsychological baseline data from patients with PD-MCI recruited in the multicentre, prospective, observational DEMPARK/LANDSCAPE study were analysed. RESULTS: 269 patients with PD-MCI (age 67...
October 2016: Journal of Neurology, Neurosurgery, and Psychiatry
Margot J Overman, Neil Pendleton, Terence W O'Neill, Gyorgy Bartfai, Felipe F Casanueva, Joseph D Finn, Gianni Forti, Giulia Rastrelli, Aleksander Giwercman, Thang S Han, Ilpo T Huhtaniemi, Krzysztof Kula, Michael E J Lean, Margus Punab, David M Lee, Elon S Correa, Tomas Ahern, Sabine M P Verschueren, Leen Antonio, Evelien Gielen, Martin K Rutter, Dirk Vanderschueren, Frederick C W Wu, Jos Tournoy
PURPOSE: Although lower levels of vitamin D have been related to poor cognitive functioning and dementia in older adults, evidence from longitudinal investigations is inconsistent. The objective of this study was to determine whether 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] levels are associated with specified measures of cognitive decline in ageing men. METHODS: The European Male Ageing Study (EMAS) followed 3369 men aged 40-79 over 4...
July 1, 2016: European Journal of Nutrition
Sasan Mosadeghi, Mark William Reid, Bibiana Martinez, Bradley Todd Rosen, Brennan Mason Ross Spiegel
BACKGROUND: Virtual reality (VR) offers immersive, realistic, three-dimensional experiences that "transport" users to novel environments. Because VR is effective for acute pain and anxiety, it may have benefits for hospitalized patients; however, there are few reports using VR in this setting. OBJECTIVE: The aim was to evaluate the acceptability and feasibility of VR in a diverse cohort of hospitalized patients. METHODS: We assessed the acceptability and feasibility of VR in a cohort of patients admitted to an inpatient hospitalist service over a 4-month period...
2016: JMIR Mental Health
Hector M González, Wassim Tarraf, Natalia Gouskova, Carlos J Rodríguez, Tatjana Rundek, Ellen Grober, Amber Pirzada, Patricia González, Pamela L Lutsey, Alvaro Camacho, Martha L Daviglus, Clinton Wright, Thomas H Mosley
BACKGROUND: Hispanics/Latinos are purportedly at increased risk for neurocognitive decline and dementias. Without dementia cures, low-cost, well-tolerated public health means for mitigating neurocognitive decline are needed. OBJECTIVE: We examined associations between neurocognition and cardiovascular health (CVH) metrics (Life's Simple 7; LS7) among diverse Hispanics/Latinos. We hypothesized that higher LS7 would be associated with healthier brain function (neurocognitive performance)...
June 18, 2016: Journal of Alzheimer's Disease: JAD
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