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https://www.readbyqxmd.com/read/27914046/production-of-computationally-designed-small-soluble-and-membrane-proteins-cloning-expression-and-purification
#1
Barsa Tripathy, Rudresh Acharya
This book chapter focuses on expression and purification of computationally designed small soluble proteins and membrane proteins that are ordinarily difficult to express in good amounts for experiments. Over-expression of such proteins can be achieved by using the solubility tag such as maltose binding protein (MBP), Thioredoxin (Trx), and Gultathione-S-transferase (GST) fused to the protein of interest. Here, we describe and provide the protocols for cloning, expression and purification of such proteins using the solubility tag...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27911773/accurate-and-scalable-social-recommendation-using-mixed-membership-stochastic-block-models
#2
Antonia Godoy-Lorite, Roger Guimerà, Cristopher Moore, Marta Sales-Pardo
With increasing amounts of information available, modeling and predicting user preferences-for books or articles, for example-are becoming more important. We present a collaborative filtering model, with an associated scalable algorithm, that makes accurate predictions of users' ratings. Like previous approaches, we assume that there are groups of users and of items and that the rating a user gives an item is determined by their respective group memberships. However, we allow each user and each item to belong simultaneously to mixtures of different groups and, unlike many popular approaches such as matrix factorization, we do not assume that users in each group prefer a single group of items...
November 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911113/a-tribute-to-professor-steven-l-wechsler-1948-2016-the-man-and-the-scientist
#3
Anthony B Nesburn, Lbachir BenMohamed
Professor Steven L. Wechsler, a world-renowned eye researcher and virologist, passed away unexpectedly on June 12, 2016 at the age of 68. Many scientists came to know Professor Wechsler as a gifted researcher in the field of ocular Herpes Simplex Virus (HSV-1) latency, reactivation, and pathogenesis. Professor Wechsler published over 150 peer-reviewed scientific papers during his career, pushing forward the frontiers of his field eye research. His colleagues would say, 'Steve literally wrote the book on herpes latency and reactivation...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27910735/birth-of-the-cool-a-two-centuries-decline-in-emotional-expression-in-anglophone-fiction
#4
Olivier Morin, Alberto Acerbi
The presence of emotional words and content in stories has been shown to enhance a story's memorability, and its cultural success. Yet, recent cultural trends run in the opposite direction. Using the Google Books corpus, coupled with two metadata-rich corpora of Anglophone fiction books, we show a decrease in emotionality in English-speaking literature starting plausibly in the nineteenth century. We show that this decrease cannot be explained by changes unrelated to emotionality (such as demographic dynamics concerning age or gender balance, changes in vocabulary richness, or changes in the prevalence of literary genres), and that, in our three corpora, the decrease is driven almost entirely by a decline in the proportion of positive emotion-related words, while the frequency of negative emotion-related words shows little if any decline...
December 2, 2016: Cognition & Emotion
https://www.readbyqxmd.com/read/27909990/orexin-hypocretin-signaling
#5
Jyrki P Kukkonen
Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX1 and OX2 orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been investigated in diverse endogenously orexin receptor-expressing cells - mainly neurons but also other types of cells - and in recombinant cells expressing the receptors in a heterologous manner. Findings in the different systems are partially convergent but also indicate cellular background-specific signaling...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27909181/emergency-radiology-coffee-case-book-case-oriented-fast-focused-effective-education
#6
E Edmund Kim
No abstract text is available yet for this article.
December 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27909020/the-design-and-transformation-of-biofundamentals-a-nonsurvey-introductory-evolutionary-and-molecular-biology-course
#7
Michael W Klymkowsky, Jeremy D Rentsch, Emina Begovic, Melanie M Cooper
Many introductory biology courses amount to superficial surveys of disconnected topics. Often, foundational observations and the concepts derived from them and students' ability to use these ideas appropriately are overlooked, leading to unrealistic expectations and unrecognized learning obstacles. The result can be a focus on memorization at the expense of the development of a meaningful framework within which to consider biological phenomena. About a decade ago, we began a reconsideration of what an introductory course should present to students and the skills they need to master...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27907224/single-versus-combination-intravenous-anti-pseudomonal-antibiotic-therapy-for-people-with-cystic-fibrosis
#8
REVIEW
Heather E Elphick, Alison Scott
BACKGROUND: Choice of antibiotic, and the use of single or combined therapy are controversial areas in the treatment of respiratory infection due to Pseudomonas aeruginosa in cystic fibrosis (CF). Advantages of combination therapy include wider range of modes of action, possible synergy and reduction of resistant organisms; advantages of monotherapy include lower cost, ease of administration and reduction of drug-related toxicity. Current evidence does not provide a clear answer and the use of intravenous antibiotic therapy in cystic fibrosis requires further evaluation...
December 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27905447/books-in-brief
#9
Barbara Kiser
No abstract text is available yet for this article.
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27905414/book-publishing-university-presses-adapt
#10
Roger Schonfeld
No abstract text is available yet for this article.
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27905265/learning-together-part-2-training-costs-and-health-gain-a-cost-analysis
#11
Katherine Cullen, Wendy Riches, Chloe Macaulay, John Spicer
: Learning Together is a complex educational intervention aimed at improving health outcomes for children and young people. There is an additional cost as two doctors are seeing patients together for a longer appointment than a standard general practice (GP) appointment. Our approach combines the impact of the training clinics on activity in South London in 2014-15 with health gain, using NICE guidance and standards to allow comparison of training options. METHODS: Activity data was collected from Training Practices hosting Learning Together...
December 1, 2016: Education for Primary Care
https://www.readbyqxmd.com/read/27905084/-book-review
#12
(no author information available yet)
No abstract text is available yet for this article.
November 30, 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27905057/book-review
#13
Chun Wang, Jack Kostal
No abstract text is available yet for this article.
November 30, 2016: Psychometrika
https://www.readbyqxmd.com/read/27904813/glycyrrhetinic-acid-might-increase-the-nephrotoxicity-of-bakuchiol-by-inhibiting-cytochrome-p450-isoenzymes
#14
Aifang Li, Nana Ma, Zijing Zhao, Mei Yuan, Hua Li, Qi Wang
BACKGROUND: Licorice, a popular traditional Chinese medicine (TCM), is widely used to moderate the effects (detoxification) of other herbs in TCM and often combined with Fructus Psoraleae. However, the classical TCM book states that Fructus Psoraleae is incompatible with licorice; the mechanism underlying this incompatibility has not been identified. Glycyrrhetinic acid (GA), the active metabolite of licorice, may increase the toxicity of bakuchiol (BAK), the main chemical ingredient in Psoralea corylifolia, by inhibiting its detoxification enzymes CYP450s...
2016: PeerJ
https://www.readbyqxmd.com/read/27903787/book-review-oxford-textbook-of-fundamentals-of-surgery
#15
Ankit Ajmera, Prakash P Punjabi
No abstract text is available yet for this article.
November 30, 2016: Perfusion
https://www.readbyqxmd.com/read/27903761/book-review-rehabilitation-a-post-critical-approach
#16
Lisette Farias
No abstract text is available yet for this article.
November 30, 2016: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/27902154/the-bell-lap-stories-for-compassionate-nursing-care-murch-muriel-a-the-bell-lap-stories-for-compassionate-nursing-care-155pp-%C3%A2-16-99-crc-press-9781785231605-178523160x-formula-see-text
#17
(no author information available yet)
Key issues around ageing and care of older people are covered in this book. It offers an impressive selection of short stories that give an insight into the lives of those who can feel vulnerable when what was once 'normal' for them gradually or suddenly changes.
November 30, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27901461/book-reviews
#18
(no author information available yet)
No abstract text is available yet for this article.
December 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27900901/whistle-blowing-and-ethics-in-health-and-social-care-ash-angie-whistle-blowing-and-ethics-in-health-and-social-care-184pp-%C3%A2-17-99-jessica-kingsley-9781849056328-1849056323-formula-see-text
#19
(no author information available yet)
Accessible in terms of language and presentation, this book's nine chapters cover three themes: organisational culture and leadership, whistle-blowing as a moral activity, and policy and regulatory systems and frameworks.
November 30, 2016: Nursing Older People
https://www.readbyqxmd.com/read/27900772/hematopoietic-stem-cell-transplantation-for-people-with-%C3%A3-thalassaemia-major
#20
REVIEW
Vanitha A Jagannath, Zbys Fedorowicz, Amani Al Hajeri, Akshay Sharma
BACKGROUND: Thalassemia is an inherited autosomal recessive blood disorder, caused by mutations in globin genes or their regulatory regions. This results in a reduced rate of synthesis of one of the globin chains that make up haemoglobin. In ß-thalassaemia major there is an underproduction of ß-globin chains combined with excess of free α-globin chains. The excess free α-globin chains precipitate in red blood cells, leading to their destruction (haemolysis) and ineffective erythropoiesis...
November 30, 2016: Cochrane Database of Systematic Reviews
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