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https://www.readbyqxmd.com/read/29667550/in-vitro-studies-on-cytotoxic-dna-protecting-antibiofilm-and-antibacterial-effects-of-biogenic-silver-nanoparticles-prepared-with-bergenia-ciliata-rhizome-extract
#1
Ghazna Zia, Haleema Sadia, Shabnam Nazir, Kiren Ejaz, Shaukat Ali, Ihsan-Ul-Haq, Tariq Iqbal, Muhammad Abdul Rauf Khan, Abida Raza, Saiqa Andleeb
BACKGROUND: Many health hazardous diseases are caused by clinical pathogens. Drug-resistant microbes are one of the major health problems in the world. To overcome the effect of infectious diseases new antimicrobial agent from nature has been explored which is environmentally friendly, less costly and more effective for the development of next-generation drugs. Bergenia ciliata and silver nitrate both have medicinal properties. OBJECTIVES: The aim of the current research was to evaluate the cytotoxic, and antibacterial effect of green synthesized nanoparticles using Bergenia ciliata rhizome against clinical bacterial pathogens...
April 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29666656/hepatitis-b-virus-infection-in-tanzania-current-status-and-challenges
#2
REVIEW
Semvua B Kilonzo, Daniel W Gunda, Bonaventura C T Mpondo, Fatma A Bakshi, Hyasinta Jaka
Hepatitis B is one of the most common infectious diseases in the world with high prevalence in most of sub-Saharan Africa countries. The complexity in its diagnosis and treatment poses a significant management challenge in the resource-limited settings including Tanzania, where most of the tests and drugs are either unavailable or unaffordable. This mini review aims at demonstrating the current status of the disease in the country and discussing the concomitant challenges in diagnosis, treatment, and prevention...
2018: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29663416/autophagy-induction-by-trehalose-molecular-mechanisms-and-therapeutic-impacts
#3
REVIEW
Kiana Hosseinpour-Moghaddam, Michele Caraglia, Amirhossein Sahebkar
The balance between synthesis and degradation is crucial to maintain cellular homeostasis and different mechanisms are known to keep this balance. In this review, we will provide a short overview on autophagy as an intracellular homeostatic degradative machinery. We will also describe the involvement of downregulation of autophagy in numerous diseases including neurodegenerative diseases, cancer, aging, metabolic disorders, and other infectious diseases. Therefore, modulation of autophagic processes can represent a promising way of intervention in different diseases including neurodegeneration and cancer...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29659523/antibacterial-efficacy-of-silver-nanoparticles-on-endometritis-caused-by-prevotella-melaninogenica-and-arcanobacterum-pyogenes-in-dairy-cattle
#4
Sangiliyandi Gurunathan, Yun-Jung Choi, Jin-Hoi Kim
Bovine postpartum diseases remain one of the most significant and highly prevalent illnesses with negative effects on the productivity, survival, and welfare of dairy cows. Antibiotics are generally considered beneficial in the treatment of endometritis; however, frequent usage of each antibiotic drug is reason for the emergence of multidrug resistance (MDR) of the pathogenic microorganisms, representing a major impediment for the successful diagnosis and management of infectious diseases in both humans and animals...
April 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29656829/-uveitis-treated-with-biotherapy-and-or-dmard-analysis-from-the-french-pharmacovigilance-study-base
#5
L Cabane, S Baillif, B Baldin, V Breuil, L Euller-Ziegler, N Tieulié
PURPOSE: To report the characteristics of uveitis cases occurring while on biologic therapy or disease-modifying antirheumatic drugs (DMARDs) reported to the French national pharmacovigilance database. METHODS: All the uveitis cases occurring in patients with chronic rheumatologic diseases, chronic inflammatory intestinal diseases or connective tissue diseases, while treated with DMARDs and/or biologic therapies between 2000 and 2015 and reported to the French National Pharmacovigilance Database were collected...
April 13, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29651937/an-emerging-role-of-endometrial-inflammasome-in-reproduction-new-therapeutic-approaches
#6
Fiorella Di Nicuolo, Monia Specchia, Lorenza Trentavizi, Giovanni Scambia, Nicoletta Di Simone
One of the common complications of pregnancy is spontaneous pregnancy loss which occurs in an estimated 5- 15% of pregnancies. Of all women 1%-5% suffer from recurrent pregnancy loss (RPL). Despite the fact that RPL has been associated to various anatomic, hormonal, immune, hematologic, and genetic defects, in 30% of the patients, screening tests included in the RPL workup may have negative results. Recently, we demonstrated a significant increased activation of endometrial NALP-3 inflammasome, and a caspase-1 dependent secretion of IL-18 and IL-1β in the endometrial tissues obtained from RPL women compared with a fertile women group...
April 12, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29651860/risk-factors-for-clostridium-difficile-infections-in-baranya-county-southern-hungary
#7
Szabolcs Vigvári, Dávid Sipos, Ágnes Kappéter, Zsófia Feiszt, Beáta Kovács, Zoltán Péterfi
In the past decade, Clostridium difficile infections (CDIs) have become a major public health challenge. Their epidemiology has radically changed with a significant rise in the number of cases and an increase in severe episodes. Recurrence and failure of conventional treatments are very common. Furthermore, a spread of CDI has emerged in general population without the usual risk factors (unexposed to antibiotic treatment, young people, etc.). The conventional treatments (metronidazole and vancomycin) are still effective and are the first-line antibiotics with new recommendations...
April 13, 2018: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/29651691/pattern-of-antimicrobial-resistance-among-bacterial-isolates-from-urogenital-clinical-specimens-a-descriptive-study-from-the-buea-health-district-cameroon
#8
Elvis Tajoache Amin, Charles Njumkeng, Belmond T Kika, Akemfua Fualefac, Patrick Njukeng
INTRODUCTION: Antimicrobial resistance has become a global concern and is particularly affecting developing countries where infectious diseases and poverty are endemic. The effectiveness of currently available antimicrobials is decreasing as a result of increasing resistant strains among clinical isolates. OBJECTIVES: The aim of this study was to determine the resistance pattern of bacterial isolates from different clinical urogenital specimens at different hospitals in the Buea Health District, Cameroon...
April 12, 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29651420/the-human-replicative-helicase-the-cmg-complex-as-a-target-for-anti-cancer-therapy
#9
REVIEW
Yeon-Soo Seo, Young-Hoon Kang
DNA helicases unwind or rearrange duplex DNA during replication, recombination and repair. Helicases of many pathogenic organisms such as viruses, bacteria, and protozoa have been studied as potential therapeutic targets to treat infectious diseases, and human DNA helicases as potential targets for anti-cancer therapy. DNA replication machineries perform essential tasks duplicating genome in every cell cycle, and one of the important functions of these machineries are played by DNA helicases. Replicative helicases are usually multi-subunit protein complexes, and the minimal complex active as eukaryotic replicative helicase is composed of 11 subunits, requiring a functional assembly of two subcomplexes and one protein...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29649840/-therapeutic-concepts-for-treatment-of-patients-with-non-infectious-uveitis-biologic-disease-modifying-antirheumatic-drugs
#10
Karoline Walscheid, Uwe Pleyer, Arnd Heiligenhaus
Biologic disease modifying antirheumatic drugs (bDMARDs) can be highly efficient in the treatment of various non-infectious uveitis entities. Currently, the TNF-α-inhibitor Adalimumab is the only in-label therapeutic option, whereas, all other bDMARDs need to be given as an off-label therapy. bDMARDs are indicated in diseases refractory to conventional synthetic DMARD therapy and/or systemic steroids, or in patients in whom treatment with those is not possible due to side effects. Therapeutic mechanisms currently employed are cytokine-specific (interferons, inhibition of TNF-α or of interleukin [IL]-1-, IL-6- or IL-17-signalling), inhibit T cell costimulation (CTLA-4 fusion protein), or act via depletion of B cells (anti-CD20)...
April 12, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29649310/administration-of-oral-fluoroquinolone-and-the-risk-of-rhegmatogenous-retinal-detachment-a-nationwide-population-based-study-in-korea
#11
Seung Yong Choi, Hyun-A Lim, Hyeon Woo Yim, Young-Hoon Park
PURPOSE: To investigate the association between oral fluoroquinolones (FQ) and the risk of rhegmatogenous retinal detachment (RRD) using a nationwide population-based study in Korea, designed to control for time-related bias. METHODS: As a nested case-control study within a cohort, the KNHIS-NSC 2002-2013 (Korean National Health Insurance Service National Sample Cohort) data used for the investigation. The subjects who visited an ophthalmologist were included in a cohort...
2018: PloS One
https://www.readbyqxmd.com/read/29649190/updated-cdc-recommendations-for-using-artemether-lumefantrine-for-the-treatment-of-uncomplicated-malaria-in-pregnant-women-in-the-united-states
#12
Sarah-Blythe Ballard, Allison Salinger, Paul M Arguin, Meghna Desai, Kathrine R Tan
Malaria infection during pregnancy is associated with an increased risk for maternal and fetal complications. In the United States, treatment options for uncomplicated, chloroquine-resistant Plasmodium falciparum and P. vivax malaria in pregnant women are limited to mefloquine or quinine plus clindamycin (1). However, limited availability of quinine and increasing resistance to mefloquine restrict these options. Strong evidence now demonstrates that artemether-lumefantrine (AL) (Coartem) is effective and safe in the treatment of malaria in pregnancy...
April 13, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29629843/folate-biosynthesis-pathway-mechanisms-and-insights-into-drug-design-for-infectious-diseases
#13
Marcio V Bertacine Dias, Jademilson C Santos, Gerardo A Libreros-Zúñiga, João A Ribeiro, Sair M Chavez-Pacheco
Folate pathway is a key target for the development of new drugs against infectious diseases since the discovery of sulfa drugs and trimethoprim. The knowledge about this pathway has increased in the last years and the catalytic mechanism and structures of all enzymes of the pathway are fairly understood. In addition, differences among enzymes from prokaryotes and eukaryotes could be used for the design of specific inhibitors. In this review, we show a panorama of progress that has been achieved within the folate pathway obtained in the last years...
April 9, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29626047/risk-factors-and-biomarkers-of-non-alcoholic-fatty-liver-disease-an-observational-cross-sectional-population-survey
#14
Xiao-Yu Hu, Yun Li, Long-Quan Li, Yuan Zheng, Jia-Hong Lv, Shu-Chun Huang, Weinong Zhang, Liang Liu, Ling Zhao, Zhuiguo Liu, Xiu-Ju Zhao
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a major public health burden in China, and its prevalence is increasing. This study aimed to determine the risk factors and biomarkers of NAFLD. DESIGN: An observational cross-sectional primary survey. SETTING: Central China. PARTICIPANTS: The study included 1479 participants aged over 18 and below 80 years, not currently being treated for cancer or infectious disease or no surgery in the previous year, and no history of cancer or an infectious disease...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29623708/-gut-microbiota-its-development-and-relation-to-certain-diseases
#15
Hana Kiňová Sepová, Boris Dudík, Andrea Bilková
Coexistence of humans with microorganisms is well known for a long time. Besides the association with infectious diseases, personal microbiota is important for human health, possibly for some non-infectious diseases. Colonization of the human body with appropriate microorganisms after delivery is essential for physiological immune system maturation and also has an influence on central nervous system development. The composition of the gut microbiota is affected by the mode of delivery, early life nutrition and last but not least by lifestyle and drug, especially antibiotics intake...
2018: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/29619441/a-new-copper-ii-imidazole-derivative-effectively-inhibits-replication-of-denv-2-in-vero-cell
#16
Teguh Hari Sucipto, Siti Churrotin, Harsasi Setyawati, Fahimah Martak, Kris Cahyo Mulyatno, Ilham Harlan Amarullah, Tomohiro Kotaki, Masanori Kameoka, Subagyo Yotopranoto, And Soegeng Soegijanto
Background: Dengue is a kind of infectious disease that was distributed in the tropical and sub-tropical areas. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the complex compounds, copper(II)-imidazole derivatives are of interest because of their biological and medicinal benefits. Materials and Methods: In the present study, antiviral activity of [Cu(2,4,5-triphenylimidazole)2 ]n , was evaluated against different stages of dengue virus type 2 (DENV-2) replication in Vero cell using focus forming unit reduction assay and quantitative ELISA...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29617899/in-ovo-applications-in-poultry-a-review
#17
E D Peebles
The various methods employed for the in ovo administration of different materials for promoting the health and productivity of poultry are discussed in this review article. The amnion has proven to be an effective site for injection and the timing of in ovo injection has commonly occurred at transfer. However, the volumes and dosages or concentrations of the materials administered vary depending on bird type, egg size, timing and site of injection, incubation system and regimen, and the type of material. Both manual and automated injections have been shown to be effective...
March 28, 2018: Poultry Science
https://www.readbyqxmd.com/read/29617685/incidence-of-antibiotic-related-rash-in-children-with-epstein-barr-virus-infection-and-evaluation-of-the-frequency-of-confirmed-antibiotic-hypersensitivity
#18
Emine Dibek Misirlioglu, Hakan Guvenir, Aslinur Ozkaya Parlakay, Muge Toyran, Hasan Tezer, Arif Ismet Catak, Can Naci Kocabas
BACKGROUND: The incidence of rash after aminopenicillin treatment in children with Epstein-Barr Virus (EBV) infection was reported to be 80-100%. A few recent studies suggested that the incidence may be much lower during EBV infection. There are no clear data on the incidence of true drug hypersensitivity among these patients. The aim of this study is to determine the incidence of rash and antibiotic allergy after antibiotic treatment in children with EBV infection. METHODS: Drug hypersensitivity was investigated in antibiotic-treated patients with a positive EBV IgM who developed a rash between 2013 and 2016...
April 4, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29615054/anti-plasmodial-effect-of-plant-extracts-from-picrolemma-huberi-and-picramnia-latifolia
#19
Wendy Berthi, Alexa González, Alexandra Rios, Silvia Blair, Álvaro Cogollo, Adriana Pabón
BACKGROUND: Malaria is an infectious disease caused by parasites of the genus Plasmodium, of which Plasmodium vivax and Plasmodium falciparum are the major species that cause the disease in humans. As there are relatively few alternatives for malaria treatment, it is necessary to search for new chemotherapeutic options. Colombia possesses a great diversity of plants, which are potential sources of new compounds of medical interest. Thus, in this study the antiplasmodial effect of extracts from two species of plants from the families Simaroubaceae and Picramniaceae (Picramnia latifolia and Picrolemma huberi) was evaluated in vitro and in vivo...
April 4, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29611626/quinoxaline-and-quinoxaline-1-4-di-n-oxides-an-emerging-class-of-antimycobacterials
#20
REVIEW
Rangappa S Keri, Sudam S Pandule, Srinivasa Budagumpi, Bhari M Nagaraja
Tuberculosis (TB) is a highly dreaded, infectious, chronic, airborne disease affecting more than two million people all around the world, with more than eight million cases every calendar year. TB is the second leading infectious cause of death after HIV/AIDS. Over the past few decades, numerous efforts have been undertaken to develop new anti-TB agents. The current frontline therapy for TB consists of administering three or more different drugs (usually isoniazid, rifampin, pyrazinamide, and ethambutol) over an extended period of time...
April 3, 2018: Archiv der Pharmazie
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