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Cancer drug delivery

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https://www.readbyqxmd.com/read/29045226/science-to-practice-molecular-targeted-drug-delivery-in-combination-with-radiofrequency-ablation-of-liver-cancer-a-magic-bullet
#1
Lucas Christoph Adam, Nikitha Murali, Julius Chapiro, Jean-François Geschwind
In an effort to improve the technical success rates and clinical outcomes of radiofrequency (RF) ablation, Yan et al validated the use of a tumor-penetrating peptide and thermosensitive doxorubicin (DOX)-loaded nanoparticles in combination with RF ablation in a hepatocellular carcinoma mouse model. By achieving higher chemotherapeutic drug concentrations in target lesions, fewer toxic effects, and improved survival end points in an animal tumor model, the authors conclude that superior tumor treatment with RF ablation is possible when combined with molecular-targeted drug delivery systems...
November 2017: Radiology
https://www.readbyqxmd.com/read/29044986/spectroscopic-investigation-of-the-anticancer-alkaloid-piperlongumine-binding-to-human-serum-albumin-from-the-viewpoint-of-drug-delivery
#2
Yu Liu, Qian-Yu Li, Yu-Ping Wang, Yi-Ming Liu, Bin Liu, Mei-Mei Liu, Bing-Mi Liu
Piperlongumine (PL) is a very promising natural agent with a high potential for cancer treatment. To overcome the poor water solubility of PL, there is a need to develop a novel water-soluble formulation in which PL is non-covalently bound to human serum albumin (HSA). PL binding to HSA was studied by various spectroscopic techniques under simulated physiological conditions. Spectroscopic evidence showed that the interaction of PL with HSA could form a PL-HSA complex. The binding constant (Ka ) values increased with increasing temperature, and a similar dependence was observed for the number of binding sites (n) values...
October 18, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29044971/drug-nanocrystals-for-cancer-therapy
#3
REVIEW
Xiaoqing Miao, Wuwei Yang, Tao Feng, Jing Lin, Peng Huang
Drug nanocrystals (NCs) with fascinating physicochemical properties have attracted great attention in drug delivery. High drug-loading efficiency, great structural stability, steady dissolution, and long circulation time are a few examples of these properties, which makes drug NCs an excellent formulation for efficient cancer therapy. In the last two decades, there are a lot of hydrophobic or lipophilic drugs, such as paclitaxel (PTX), camptothecin (CPT), thymectacin, busulfan, cyclosporin A, 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide (HPPH), and so on, which have been formulated into drug NCs for cancer therapy...
October 17, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29044377/heparosan-coated-liposomes-for-drug-delivery
#4
Rachel S Lane, F Michael Haller, Anais A E Chavaroche, Andrew Almond, Paul L DeAngelis
Liposomal encapsulation is a useful drug delivery strategy for small molecules, especially chemotherapeutic agents such as doxorubicin. Doxil® is a doxorubicin-containing liposome ("dox-liposome") that passively targets drug to tumors while reducing side effects caused by free drug permeating and poisoning healthy tissues. Polyethylene glycol (PEG) is the hydrophilic coating of Doxil® that protects the formulation from triggering the mononuclear phagocyte system (MPS). Evading the MPS prolongs dox-liposome circulation time thus increasing drug deposition at the tumor site...
November 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/29044154/cryo-em-visualization-of-lipid-and-polymer-stabilized-perfluorocarbon-gas-nanobubbles-a-step-towards-nanobubble-mediated-drug-delivery
#5
Christopher Hernandez, Sahil Gulati, Gabriella Fioravanti, Phoebe L Stewart, Agata A Exner
Gas microbubbles stabilized with lipids, surfactants, proteins and/or polymers are widely used clinically as ultrasound contrast agents. Because of their large 1-10 µm size, applications of microbubbles are confined to the blood vessels. Accordingly, there is much interest in generating nanoscale echogenic bubbles (nanobubbles), which can enable new uses of ultrasound contrast agents in molecular imaging and drug delivery, particularly for cancer applications. While the interactions of microbubbles with ultrasound have been widely investigated, little is known about the activity of nanobubbles under ultrasound exposure...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044153/tripalmitin-nanoparticle-formulations-significantly-enhance-paclitaxel-antitumor-activity-against-breast-and-lung-cancer-cells-in-vitro
#6
María Carmen Leiva, Raúl Ortiz, Rafael Contreras-Cáceres, Gloria Perazzoli, Iryna Mayevych, Juan Manuel López-Romero, Francisco Sarabia, Jose Manuel Baeyens, Consolación Melguizo, Jose Prados
Paclitaxel (PTX) is one of the drugs of choice in the treatment of breast and lung cancer. However, its severe side effects, including mielosuppression, cardiotoxicity and neurotoxicity, frequently cause treatment to be discontinued. Solid lipid nanoparticles (NPs) of glyceril tripalmitate (tripalmitin) loaded with PTX (Tripalm-NPs-PTX) including modifications by the addition of hexa(ethylene glycol), β-cyclodextrin and macelignan were developed. All NPs-PTX formulations displayed excellent hemocompatibility and significantly enhanced PTX antitumor activity in human breast (MCF7, MDAMB231, SKBR3 and T47D) and lung (A549, NCI-H520 and NCI-H460) cancer cells...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043319/triple-function-nanocomposites-of-porous-silica-cofe2o4-mwcnts-as-a-carrier-for-ph-sensitive-anti-cancer-drug-controlled-delivery
#7
Huitao Fan, Xiaojing Xing, Yuhan Yang, Bo Li, Congcong Wang, Dongfang Qiu
Cobalt ferrite nanoparticles loaded on multiwalled carbon nanotube (MWCNT) magnetic hybrids have been demonstrated to be promising magnetic resonance imaging contrast agents and drug carriers. However, the hydrophobic, less biocompatible characteristics and low loading capacity for the drug hamper their wide biological applications. To solve the above problem, an alternative strategy is to coat the MWCNTs@CoFe2O4 nanoparticles with a mesoporous silica (mSiO2) shell. Herein, the reasonable fabrication process results in successful coating mSiO2 on the as-obtained MWCNTs@CoFe2O4 nanoparticles, forming well-defined core-shell-structured MWCNTs@CoFe2O4@mSiO2 nanocomposites...
October 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29039917/multifunctional-theranostic-nanoparticles-based-on-exceedingly-small-magnetic-iron-oxide-nanoparticles-for-t1-weighted-magnetic-resonance-imaging-and-chemotherapy
#8
Zheyu Shen, Tianxiang Chen, Xuehua Ma, Wenzhi Ren, Zijian Zhou, Guizhi Zhu, Ariel Zhang, Yijing Liu, Jibin Song, Zihou Li, Huimin Ruan, Wenpei Fan, Lisen Lin, Jeeva Munasinghe, Xiaoyuan Chen, Aiguo Wu
The recently emerged exceedingly small magnetic iron oxide nanoparticles (ES-MIONs) (< 5 nm) are promising T1-weighted contrast agents for magnetic resonance imaging (MRI) due to their good biocompatibility compared with Gd-chelates. However, the best particle size of ES-MIONs for T1 imaging is still unknown because the synthesis of ES-MIONs with precise size control to clarify the relationship between the r1 (or r2/r1) and the particle size remains a challenge. In this study, we synthesized ES-MIONs with 7 different sizes below 5 nm and found that 3...
October 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/29039650/programmed-nanococktail-based-on-ph-responsive-function-switch-for-self-synergistic-tumor-targeting-therapy
#9
Yang Li, Liang Song, Jinyan Lin, Zhou Pan, Jinyuan Ma, Yinying Zhang, Guanghao Su, Shefang Ye, Fang-Hong Luo, Xuan Zhu, Zhenqing Hou
Tumor-targeting combination chemotherapy is an important way to improve the therapeutic index and reduce the side effects compared to traditional cancer treatments. However, one of the major challenges in surface functionalization of nanoparticle (NP) is accomplishing multiple purposes through one single ligand. Upon such consideration, methotrexate (MTX), an anticancer drug with a targeting moiety inspired by the similar structure of folate, could be used to covalently link with lipid-polymer conjugate (DSPE-PEG) via pH-sensitive dynamic covalent imine (CH=N) bond to synthesize the acid-induced function "Targeting-Anticancer" switching DSPE-PEG-CH=N-MTX...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29039088/evaluating-nanomedicines-obstacles-and-advancements
#10
Magdalena Swierczewska, Rachael M Crist, Scott E McNeil
Continued advancements in nanotechnology are expanding the boundaries of medical research, most notably as drug delivery agents for treatment against cancer. Drug delivery with nanotechnology can offer greater control over the biodistribution of therapeutic agents to improve the therapeutic index. In the last 20 years, a number of nanomedicines have transitioned into the clinic. As nanomedicines evolve, techniques to properly evaluate their safety and efficacy must also evolve. Characterization methods for nano-based materials must be adapted to the demands of nanomedicine developers and regulators...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29038232/tissue-force-programs-cell-fate-and-tumor-aggression
#11
REVIEW
Jason J Northey, Laralynne Przybyla, Valerie M Weaver
Biomechanical and biochemical cues within a tissue collaborate across length scales to direct cell fate during development and are critical for the maintenance of tissue homeostasis. Loss of tensional homeostasis in a tissue not only accompanies malignancy but may also contribute to oncogenic transformation. High mechanical stress in solid tumors can impede drug delivery and may additionally drive tumor progression and promote metastasis. Mechanistically, biomechanical forces can drive tumor aggression by inducing a mesenchymal-like switch in transformed cells so that they attain tumor-initiating or stem-like cell properties...
October 16, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29036899/targeting-strategies-for-the-combination-treatment-of-cancer-using-drug-delivery-systems
#12
REVIEW
Janel Kydd, Rahul Jadia, Praveena Velpurisiva, Aniket Gad, Shailee Paliwal, Prakash Rai
Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy treatment-due to the hostile tumor microenvironment-that create a significant challenge for effective therapeutic regimens. Multidrug resistance, collateral toxicity to normal cells, and detrimental systemic side effects present significant obstacles, necessitating alternative and safer treatment strategies. Traditional administration of chemotherapeutics has demonstrated minimal success due to the non-specificity of action, uptake and rapid clearance by the immune system, and subsequent metabolic alteration and poor tumor penetration...
October 14, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/29036883/microrna-34a-a-versatile-regulator-of-myriads-of-targets-in-different-cancers
#13
REVIEW
Ammad Ahmad Farooqi, Sobia Tabassum, Aamir Ahmad
MicroRNA-34a (miR-34a) is a tumor suppressor that has attracted considerable attention in recent years. It modulates cancer cell invasion, metastasis, and drug resistance, and has also been evaluated as a diagnostic and/or prognostic biomarker. A number of targets of miR-34a have been identified, including some other non-coding RNAs, and it is believed that the modulation of these myriads of targets underlines the versatile role of miR-34a in cancer progression and pathogenesis. Seemingly appealing results from preclinical studies have advocated the testing of miR-34a in clinical trials...
October 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29035823/ratiometric-drug-delivery-using-non-liposomal-nanocarriers-as-an-approach-to-increase-efficacy-and-safety-of-combination-chemotherapy
#14
REVIEW
Marina Santiago Franco, Mônica Cristina Oliveira
The observation that different drug ratios of the same drug combination can lead to synergistic or antagonistic effects when tested against the same cancer cell line in vitro gave rise to a new trend, the ratiometric delivery. This strategy consists of co-encapsulating a specific synergistic ratio of a drug combination into a nanocarrier so that synergism observed in vitro will be faithfully translated to in vivo, optimizing combination therapy. In this review we focus on how to quantify synergism in vitro, followed by how this affected the evolution of nanocarriers culminating in the ratiometric delivery, and finally we summarize the results of the non-liposomal formulations that were built upon this concept...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29035739/physical-oncology-new-targets-for-nanomedicine
#15
REVIEW
Alba Nicolas-Boluda, Amanda K A Silva, Sylvie Fournel, Florence Gazeau
Physical oncology is an emerging paradigm which recognizes tissue mechanics, per se, as an active modulator of tumorigenesis, treatment resistance and clinical outcome, mediated by mechanosignaling pathways, matrix remodeling and physical barriers to drugs. The tumor microenvironment displays abnormal physical properties in comparison to healthy tissue which contribute to cancer progression and resistance to current treatments. Physical aberrancies comprise the chaotic organization of tumor vasculature, an increased interstitial pressure, an increased solid stress, hypoxia, an abundant extracellular matrix and a progressive stiffening of solid tumors...
October 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/29035507/sequential-delivery-of-doxorubicin-and-zoledronic-acid-to-breast-cancer-cells-by-cb-7-modified-iron-oxide-nanoparticles
#16
Farah Benyettou, Marwa Alhashimi, Matthew O'Connor, Renu Pasricha, Jérémy Brandel, Hassan Trabousli, Javed Mazher, John-Carl Olsen, Ali Trabolsi
Drug-loaded magnetic nanoparticles were synthesized and used for the sequential delivery of the anti-resorptive agent zoledronic acid (Zol) and the cytotoxic drug doxorubicin (Dox) to breast cancer cells (MCF-7). Zol was attached to bare iron oxide nanoparticles (IONPs) via phosphonate coordination to form Z-NPs. The unbound imidazole of Zol was then used to complex the organic macrocycle CB[7] to obtain CZ-NPs. Dox was then complexed to the CZ-NPs to form the fully loaded particles (DCZ-NPs), which were stable in solution at 37 ºC and physiological pH (7...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29034940/near-infrared-light-and-ph-responsive-au-carbon-calcium-phosphate-nanoparticles-for-imaging-and-chemo-photothermal-cancer-therapy-of-cancer-cells
#17
Huiyuan Wang, Manjie Zhang, Lingyu Zhang, Shengnan Li, Lu Li, Xiliang Li, Min Yu, Zhongcheng Mou, Tingting Wang, Chungang Wang, Zhongmin Su
A simple, mild and reproducible synthetic route was developed to fabricate the multifunctional Au@carbon/calcium phosphate core-shell nanoparticles (Au@C/CaP NPs), which act as an efficient nanoplatform for pH/near-infrared (NIR) dual-responsive drug delivery, X-ray computed tomography (CT) imaging and synergistic chemo-photothermal cancer therapy in vitro.
October 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29034837/dual-purpose-injectable-doxorubicin-conjugated-alginate-gel-containing-polycaprolactone-microparticles-for-anti-cancer-and-anti-inflammatory-therapy
#18
Vaishali Pawar, Vivek Borse, Riya Thakkar, Rohit Srivastava
In situ gel formulations have been widely reported as a carrier for sustained release delivery systems due to certain advantages such as targeted drug delivery, minimal invasiveness and potent therapeutic activity. Herein, in situ gel system for sustained release of doxorubicin and ibuprofen for anti-cancer and anti-inflammatory activity is reported. Doxorubicin-conjugated alginate (dox-alg) gel was prepared using EDC-NHS chemistry and loaded with ibuprofen encapsulated polycaprolactone (PCL) microparticles (dox-alg composite)...
October 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29034126/development-and-characterization-of-methylene-blue-oleate-salt-loaded-polymeric-nanoparticles-and-their-potential-application-as-a-treatment-for-glioblastoma
#19
J M Castañeda-Gill, A P Ranjan, J K Vishwanatha
Glioblastoma (GBM) is an aggressive, grade IV brain tumor that develops from astrocytes located within the cerebrum, resulting in poor prognosis and survival rates following an accepted treatment regimen of surgery, radiation, and temozolomide. Thus, development of new therapeutics is necessary. During the last two decades, methylene blue (MB) has received increased attention as a potential neurotherapeutic due to its duality in brain cancers and neurodegenerative diseases. While MB is capable of easily permeating the blood-brain barrier, its therapeutic concentrations in GBM are known to induce off-target cytotoxicity and thus, another mode of drug delivery must be considered...
August 2017: Journal of Nanomedicine & Nanotechnology
https://www.readbyqxmd.com/read/29033565/double-receptor-targeting-multifunctional-iron-oxide-nanoparticles-drug-delivery-system-for-the-treatment-and-imaging-of-prostate-cancer
#20
Md Shakir Uddin Ahmed, Ahmad Bin Salam, Clayton Yates, Kyle Willian, Jesse Jaynes, Timothy Turner, Mohamed O Abdalla
As an alternative therapeutic treatment to reduce or eliminate the current side effects associated with advanced prostate cancer (PCa) chemotherapy, a multifunctional double-receptor-targeting iron oxide nanoparticles (IONPs) (luteinizing hormone-releasing hormone receptor [LHRH-R] peptide- and urokinase-type plasminogen activator receptor [uPAR] peptide-targeted iron oxide nanoparticles, LHRH-AE105-IONPs) drug delivery system was developed. Two tumor-targeting peptides guided this double-receptor-targeting nanoscale drug delivery system...
2017: International Journal of Nanomedicine
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