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https://www.readbyqxmd.com/read/29908299/construction-and-biological-evaluation-of-different-self-assembled-nanoarchitectures-of-fzu-03-010
#1
Tingting Lv, Liang Xu, Guolin Wu, Cailong Li, Yibo Wen, Tao Zhang, Haijun Chen, Yu Gao
Chemotherapy is currently one of the promising therapeutic methods for non-small-cell lung cancer (NSCLC), but the emergence of multidrug resistance (MDR) is the greatest obstacle to efficient drug delivery for successful chemotherapy. Nanotechnology-based drug delivery holds great promise to promote intracellular drug delivery to reverse MDR. In this work, we used our previously synthesized ursolic acid (UA) derivative, FZU-03,010 (F3), to prepare nanodrugs of F3 with different architectures and study the role of the structure on the physiochemical properties and the biological effects against A549 and its PTX-resistant A549/PTX lung cancer cells...
June 13, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29908100/exosomes-in-cancer-development-and-clinical-applications
#2
REVIEW
Yu-Ling Tai, Ko-Chien Chen, Jer-Tsong Hsieh, Tang-Long Shen
Exosomes participate in cancer progression and metastasis by transferring bioactive molecules between cancer and varied cells in the local and distant microenvironments. Such intercellular cross-talks result in changes in multiple cellular and biological functions in recipient cells. Several hallmarks of cancer have been reportedly impacted by this exosome-mediated cell-to-cell communication, including modulating immune responses, re-programming stromal cells, re-modeling the architecture of extracellular matrix, or even endowing cancer cells with characteristics of drug resistance...
June 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29908009/amphiphilic-y-shaped-miktoarm-star-copolymer-for-anti-cancer-hydrophobic-and-hydrophilic-drugs-co-delivery-synthesis-characterization-in-vitro-and-in-vivo-biocompatibility-study
#3
Mozhgan Aghajanzadeh, Mostafa Zamani, Hamid Rashidzadeh, Kobra Rostamizadeh, Ali Sharafi, Hossein Danafar
In this project, a core-shell Polymersome based on miktoarm star-copolymer: methoxy Poly Ethylene Glycol-Lysine-(Poly Caprolactone)2 (PEG-Lys-PCL2 ) was synthesized by a new method as controlled targeted drug delivery systems for co-delivery of the chemotherapeutic methotrexate (MTX) and curcumin (CUR). Some properties of these nano carriers (NCs) such as surface morphology, structure, surface charge, stability and biocompatibility were evaluated by Proton nuclear magnetic resonance (1 HNMR), dynamic scanning colorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), Dynamic light scattering (DLS), atomic force microscopy (AFM), Critical aggregation concentration (CAC), hemolysis test, MTT assay and lethal dose 50 (LD50)...
June 16, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29907974/the-fabrication-of-rgo-pll-pasp-3-dox-nanorods-with-ph-switch-for-photothermal-therapy-and-chemotherapy
#4
Xiangming Li, Yihe Zhang, Zequn Ma, Meng Fu, Qi An
The development of well-controlled drug carriers that are stable and highly effective for the delivery of anticancer agents is challenging. Herein, we report a novel pH-controlled drug delivery system, utilizing reducing graphene oxide (rGO) -polymer self-assembly films as carriers, for the preparation of effective drug nanocomplex. In this system, rGO-polymer carriers were constructed by the alternating assembly of poly-L-lysine (PLL) and polyaspartic acid (PASP) around the rGO sheets. Furthermore, the rGO-polymer cores could assemble with negatively charged doxorubicin (DOX) via electrostatic interactions...
June 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29906554/flim-reveals-alternative-ev-mediated-cellular-up-take-pathways-of-paclitaxel
#5
REVIEW
H Saari, E Lisitsyna, K Rautaniemi, T Rojalin, L Niemi, O Nivaro, T Laaksonen, M Yliperttula, E Vuorimaa-Laukkanen
In response to physiological and artificial stimuli, cells generate nano-scale extracellular vesicles (EVs) by encapsulating biomolecules in plasma membrane-derived phospholipid envelopes. These vesicles are released to bodily fluids, hence acting as powerful endogenous mediators in intercellular signaling. EVs provide a compelling alternative for biomarker discovery and targeted drug delivery, but their kinetics and dynamics while interacting with living cells are poorly understood. Here we introduce a novel method, fluorescence lifetime imaging microscopy (FLIM) to investigate these interaction attributes...
June 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29906508/platinated-graphene-oxide-a-nanoplatform-for-efficient-gene-chemo-combination-cancer-therapy
#6
Peng Liu, Shengfeng Wang, Xuanjun Liu, Jinsong Ding, Wenhu Zhou
Cisplatin (CisPt) is one of the most effective antitumor drugs against a wide range of solid cancers, and recent studies have indicated that combination of CisPt and RNA interference (RNAi) agents would effectively enhance therapeutic index, while the development of simple yet robust dual-delivery systems still remains a challenge. Here, we demonstrated that platinated graphene oxide is an excellent platform to achieve such goal. Nano-Graphene oxide (NGO) was easily platinated by CisPt, and the resulting CisPt/NGO was characterized by several aspects...
June 12, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29906389/biotin-tagged-polysaccharide-vesicular-nanocarriers-for-receptor-mediated-anticancer-drug-delivery-in-cancer-cells
#7
Nilesh Umakant Deshpande, Manickam Jayakannan
Biotin-conjugated multi-stimuli-responsive polysaccharide vesicular nanocarriers are designed and developed, for the first time, to accomplish receptor-mediated endocytosis in cancer cells and to deliver anticancer drugs at the intracellular compartments. For this purpose, a new renewable hydrophobic unit was custom designed with redox-degradable disulphide and enzyme-biodegradable aliphatic ester chemical linkages and it was conjugated along with biotin on the dextran backbone. The dextran derivative self-assembled into nanovesicles of < 200 nm in size which were characterized by dynamic and static light scattering, electron and atomic force microscopes...
June 15, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29905493/carbon-nanotubes-in-the-delivery-of-anticancer-herbal-drugs
#8
Hardi Jogi, Rahul Maheshwari, Nidhi Raval, Kaushik Kuche, Vishakha Tambe, Kit-Kay Mak, Mallikarjuna Rao Pichika, Rakesh Kumar Tekade
Cancer is estimated to be a significant health problem of the 21st century. The situation gets even tougher when it comes to its treatment using chemotherapy employing synthetic anticancer molecules with numerous side effects. Recently, there has been a paradigm shift toward the adoption of herbal drugs for the treatment of cancer. In this context, a suitable delivery system is principally warranted to deliver these herbal biomolecules specifically at the tumorous site. To achieve this goal, carbon nanotubes (CNTs) have been widely explored to deliver anticancer herbal molecules with improved therapeutic efficacy and safety...
June 15, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29905462/the-human-biomolecular-corona-of-liposomal-doxorubicin-the-overlooked-factor-in-anticancer-drug-delivery
#9
Giulio Caracciolo, Sara Palchetti, Luca Digiacomo, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Heinz Amenitsch, Paolo Maria Tentori, Valentina Palmieri, Massimiliano Papi, Francesco Cardarelli, Daniela Pozzi, Aldo Laganà
More than twenty years after its approval by the Food and Drug Administration (FDA) liposomal doxorubicin (DOX) is still the drug of choice for the treatment of breast cancer and other conditions such as ovarian cancer and multiple myeloma. Yet, despite the efforts, liposomal DOX did not satisfy expectations at the clinical level. When liposomal drugs enter a physiological environment, their surface gets coated by a dynamic biomolecular corona (BC). The BC changes liposome's synthetic identity, providing it with a new one, referred to as 'biological identity' (size, aggregation state, and BC composition)...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29905067/surface-functionalization-of-polymeric-nanoparticles-with-umbilical-cord-derived-mesenchymal-stem-cell-membrane-for-tumor-targeted-therapy
#10
Na Yang, Yanping Ding, Yinlong Zhang, Bin Wang, Xiao Zhao, Keman Cheng, Yixin Huang, Mohammad Taleb, Jing Zhao, Wen-Fei Dong, Lirong Zhang, Guangjun Nie
Multiple cell plasma membranes have been utilized for surface functionalization of synthetic nanomaterials and construction of biomimetic drug delivery systems for cancer treatment. The natural characters and facile isolation of original cells facilitate the biomedical applications of plasma membranes in functionalizing nanocarriers. Human umbilical cord-derived mesenchymal stem cells (MSC) have been identified to show tropism towards malignant lesions and have great advantages in ease of acquisition, low immunogenicity, and high proliferative ability...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29903061/self-assembly-of-succinated-paclitaxel-into-supramolecular-hydrogel-for-local-cancer-chemotherapy
#11
Qianqian Song, Renshu Zhang, Lei Lei, Xingyi Li
In the present study, we reported the generation of a molecular hydrogel of succinated paclitaxel (PTX-SA) by a self-hydrolytic strategy for potential local cancer chemotherapy. Upon self-hydrolysis of the ester bond of PTX-SA in phosphate-buffered saline (pH = 7.4) for 24 h, a PTX-SA supramolecular hydrogel formed spontaneously with a minimal gelation concentration of 0.25 wt%. The formed PTX-SA supramolecular hydrogel displayed a filamentous nanostructure, the nanofibers of which were typically several micrometers in length with a diameter of 10-15 nm...
August 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29903056/viral-capsids-mimicking-based-on-ph-sensitive-biodegradable-polymeric-micelles-for-efficient-anticancer-drug-delivery
#12
Lutao Jiang, Yan Liang, Qingqing Huo, Yuji Pu, Wei Lu, Shangcong Han, Jie Cao, Bin He, Yong Sun
Bio-inspired supramolecular self-assembly have been widely explored in biomedical engineering, especially in the field of drug delivery. Here, viral capsid analogue pH-Sensitive polymeric micelles HA-Hyd-DOX were reported, where natural polysacarrides hyaluronic acid (HA) and anticancer drug doxorubicin (DOX), were linked through a hydrazone bond with a high drug loading content of 33.09 wt%. The polymeric micelles look like artificial virus capsids from "core-shell" structures. In addition, the polymeric backbone HA and hydrazone bonds were destroyed in the presence of hyaluronidase in cancer cells and under the acidic conditions of pH = 5 respectively, thereby prodrug-based polymeric micelles could penetrate into the tumor and DOX could be released in lysosomes to enhance anticancer efficacy...
August 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29902537/nucleolin-is-expressed-in-patient-derived-samples-and-glioblastoma-cells-enabling-improved-intracellular-drug-delivery-and-cytotoxicity
#13
Joana Balça-Silva, Anália do Carmo, Hermínio Tão, Olinda Rebelo, Marcos Barbosa, Vivaldo Moura-Neto, Ana Bela Sarmento-Ribeiro, Maria Celeste Lopes, João Nuno Moreira
One of the major challenges in Glioblastoma (GBM) therapy relates with the existence of glioma stem-like cells (GSCs), known to be chemo- and radio-resistant. GSCs and non-stem GBM cells have the ability to interchange, emphasizing the importance of identifying common molecular targets among those cell sub-populations. Nucleolin overexpression has been recently associated with breast cancer sub-populations with different stem-like phenotype. The goal of this work was to evaluate the potential of cell surface nucleolin as a target in GBM cells...
June 11, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29902013/glutathione-scavenging-poly-disulfide-amide-nanoparticles-for-effective-delivery-of-pt-iv-prodrugs-and-reversal-of-cisplatin-resistance
#14
Xiang Lin, Xing Chen, Imogen A Riddell, Wei Tao, Junqing Wang, Geoffrey Hollett, Stephen J Lippard, Omid C Farokhzad, Jinjun Shi, Jun Wu
Despite the broad antitumor spectrum of cisplatin, its therapeutic efficacy in cancer treatment is compromised by development of drug resistance in tumor cells and systemic side effects. A close correlation has been drawn between cisplatin resistance in tumor cells and increased levels of intracellular thiol-containing species, especially glutathione (GSH). The construction of a unique nanoparticle (NP) platform composed of poly(disulfide amide) polymers with a high disulfide density for effective delivery of Pt(IV) prodrugs capable of reversing cisplatin resistance through disulfide group-based GSH-scavenging process, as described herein, is a promising route to overcome limitations associated with tumor resistance...
June 14, 2018: Nano Letters
https://www.readbyqxmd.com/read/29902012/tumor-targeted-nanoparticles-deliver-a-vitamin-d-based-drug-payload-for-treatment-of-egfr-tyrosine-kinase-inhibitor-resistant-lung-cancer
#15
Chang Liu, Tatiana Shaurova, Suzanne Shoemaker, Martin Petkovich, Pamela A Hershberger, Yun Wu
Mutation in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene drives the development of lung cancer. EGFR tyrosine kinase inhibitors (EGFR TKI) including erlotinib and afatinib are initially effective in treating EGFR mutant non-small cell lung cancer (NSCLC). However, drug resistance quickly develops due to several mechanisms, including induction of the epithelial-mesenchymal transition (EMT). No effective therapies are currently available for patients who develop EMT-associated EGFR TKI resistance...
June 14, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29901986/ultrasound-triggered-conversion-of-porphyrin-camptothecin-fluoroxyuridine-triad-microbubbles-into-nanoparticles-overcomes-multidrug-resistance-in-colorectal-cancer
#16
Min Chen, Xiaolong Liang, Chuang Gao, Ranran Zhao, Nisi Zhang, Shumin Wang, Wen Chen, Bo Zhao, Jinrui Wang, Zhifei Dai
Multidrug resistance remains a major obstacle to efficient chemotherapy of colorectal cancer. Herein, an efficient drug delivery and combination therapeutic strategy is proposed based on porphyrin/camptothecin-fluxoridine triad microbubbles (PCF-MBs), which show remarkably high drug loading content, highly stable co-delivery drug combinations and no premature release. The triad PCF-MBs can act not only as a contrast agent for ultrasound/fluorescence bi-modal imaging but also a multi-modal therapeutic agent for synergetic combined chemo-photodynamic therapy...
June 14, 2018: ACS Nano
https://www.readbyqxmd.com/read/29899537/preliminary-investigation-of-focused-ultrasound-facilitated-drug-delivery-for-the-treatment-of-leptomeningeal-metastases
#17
Meaghan A O'Reilly, Tricia Chinnery, My-Linh Yee, Sheng-Kai Wu, Kullervo Hynynen, Robert S Kerbel, Gregory J Czarnota, Kathleen I Pritchard, Arjun Sahgal
Leptomeningeal metastases (LM) are a serious complication of cancer in the central nervous system (CNS) and are diagnosed in approximately 5% of patients with solid tumors. Effective treatment using systemically administered therapeutics is hindered by the barriers of the CNS. Ultrasound can mediate delivery of drugs through these barriers. The goal of this study was to test the feasibility of using ultrasound-mediated drug delivery to improve the treatment of LM. LM was induced in the spinal cord of athymic rats by injecting HER2-expressing breast cancer cells into the subarachnoid space of the thoracic spine...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29898774/arsenic-trioxide-induces-cell-cycle-arrest-and-affects-trk-receptor-expression-in-human-neuroblastoma-sk-n-sh-cells
#18
Xilin Xiong, Yang Li, Ling Liu, Kai Qi, Chi Zhang, Yueqin Chen, Jianpei Fang
BACKGROUND: Arsenic trioxide (As2 O3 ), a drug that has been used in China for approximately two thousand years, induces cell death in a variety of cancer cell types, including neuroblastoma (NB). The tyrosine kinase receptor (Trk) family comprises three members, namely TrkA, TrkB and TrkC. Various studies have confirmed that TrkA and TrkC expression is associated with a good prognosis in NB, while TrkB overexpression can lead to tumor cell growth and invasive metastasis. Previous studies have shown that As2 O3 can inhibit the growth and proliferation of a human NB cell line and can also affect the N-Myc mRNA expression...
June 13, 2018: Biological Research
https://www.readbyqxmd.com/read/29898364/hyaluronic-acid-surface-modified-liposomes-prepared-via-orthogonal-aminoxy-coupling-synthesis-of-nontoxic-aminoxylipids-based-on-symmetrically-%C3%AE-branched-fatty-acids-preparation-of-liposomes-by-microfluidic-mixing-and-targeting-to-cancer-cells-expressing-cd44
#19
Eliška Bartheldyová, Roman Effenberg, Josef Mašek, Lubomir Prochazka, Pavlína Knötigová, Pavel Kulich, Frantisek Hubatka, Kamila Velinska, Jaroslava Zelnickova, Darina Zouharova, Martina Fojtíková, Dominik Hrebik, Pavel Plevka, Robert Mikulík, Andrew David Miller, Stuart Macaulay, Daniel Zyka, Ladislav Drož, Milan Raška, Miroslav Ledvina, Jaroslav Turanek
New synthetic aminoxy lipids are designed and synthesized as building blocks for the formulation of functionalised nanoliposomes by microfluidisation using a NanoAssemblr®. Orthogonal binding of hyaluronic acid onto the outer surface of functionalised nanoliposomes via aminoxy coupling (N-oxy ligation) is achieved at hemiacetal function of hyaluronic acid and the structure of hyaluronic acid-liposomes is visualised by transmission electron microscopy and cryo- transmission electron microscopy. Observed structures are in a good correlation with data obtained by dynamic light scattering (size and ζ-potential)...
June 13, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29897733/stimuli-responsive-nano-carrier-for-co-delivery-of-mir-31-and-doxorubicin-to-suppress-high-mtef4-cancer
#20
Fang Wang, Lingyun Zhang, Xiufeng Bai, Xintao Cao, Xiangyu Jiao, Yan Huang, Yansheng Li, Yan Qin, Yongqiang Wen
Gene interference-based therapeutics represents a fascinating challenge and shows enormous potential for cancer treatment, in which microRNA is used to correct abnormal gene. Based on the above, we introduced microRNA-31 to bind to 3' untranslated region of mtEF4, resulting in the downregulation of its messenger RNA and protein to trigger cancer cells apoptosis through mitochondria-related pathway. To achieve better therapeutic effect, a mesoporous silica nanoparticles-based controlled nanoplatform had been developed...
June 13, 2018: ACS Applied Materials & Interfaces
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