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https://www.readbyqxmd.com/read/28544213/bac-recombineering-of-the-agouti-loci-from-spotted-gar-and-zebrafish-reveals-the-evolutionary-ancestry-of-dorsal-ventral-pigment-asymmetry-in-fish
#1
Laura Cal, Manuel MegÍas, José Miguel Cerdá-Reverter, John H Postlethwait, Ingo Braasch, Josep Rotllant
Dorsoventral pigment patterning, characterized by a light ventrum and a dark dorsum, is one of the most widespread chromatic adaptations in vertebrate body coloration. In mammals, this countershading depends on differential expression of agouti-signaling protein (ASIP), which drives a switch of synthesis of one type of melanin to another within melanocytes. Teleost fish share countershading, but the pattern results from a differential distribution of multiple types of chromatophores, with black-brown melanophores most abundant in the dorsal body and reflective iridophores most abundant in the ventral body...
May 24, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28543966/development-of-a-quantitative-assessment-method-of-pigmentary-skin-disease-using-ultraviolet-optical-imaging
#2
Onseok Lee, Sunup Park, Jaeyoung Kim, Chilhwan Oh
BACKGROUND/PURPOSE: The visual scoring method has been used as a subjective evaluation of pigmentary skin disorders. Severity of pigmentary skin disease, especially melasma, is evaluated using a visual scoring method, the MASI (melasma area severity index). This study differentiates between epidermal and dermal pigmented disease. The study was undertaken to determine methods to quantitatively measure the severity of pigmentary skin disorders under ultraviolet illumination. METHODS: The optical imaging system consists of illumination (white LED, UV-A lamp) and image acquisition (DSLR camera, air cooling CMOS CCD camera)...
May 21, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28543699/immune-and-molecular-correlates-in-melanoma-treated-with-immune-checkpoint-blockade
#3
REVIEW
Elizabeth H Byrne, David E Fisher
Immunotherapy for metastatic melanoma has a decades-long history, and the relatively recent use of checkpoint inhibitors has revolutionized treatment. Durable and sometimes complete remission of metastatic melanoma is now achievable in some patients who receive checkpoint-blocking therapy. However, it is unclear why some patients fare better than others. This review highlights several molecular indicators of response to checkpoint inhibition in metastatic melanoma, focusing on tumor programmed death ligand 1 expression, major histocompatibility complex class I expression, mutational load in the tumor, and T-cell infiltration into the tumor...
June 1, 2017: Cancer
https://www.readbyqxmd.com/read/28541873/an-unusual-presentation-of-seborrheic-keratoses-in-a-man-with-hereditary-hemochromatosis
#4
Tiffany Y Loh, Philip R Cohen
Hereditary hemochromatosis is an autosomal recessive disorder that disturbs iron metabolism and results in iron deposition throughout the body. Iron accumulation in various organs may cause a wide range of systemic symptoms and cutaneous manifestations of the disease are particularly striking. Classically, hereditary hemochromatosis has been termed "bronze diabetes." Although diffuse hyperpigmentation is a well-described feature of this disease, other cutaneous symptoms may also occur, and a variety of anomalies may be observed...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28540108/scalpel-depigmentation-and-surgical-crown-lengthening-to-improve-anterior-gingival-esthetics
#5
K C Chethana, K Pradeep
A smile is a mesmerizing expression of joy, success, courtesy and reveals self-confidence. The harmony of the smile is determined not only by the shape, position and the color of teeth, but also by the gingival architecture. Gingival tissues form an important part of what we can consider to be a pleasing smile. The elegance of this pleasant smile could be, affected by highly pigmented gingiva. This gingival pigmentation occurs as a result of melanin granules, which are produced by melanoblast. Although melanin pigmentation does not present a medical problem, demand for cosmetic therapy is commonly sort by people with moderately pigmented gingiva...
November 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28539864/comparative-evaluation-of-diode-laser-ablation-and-surgical-stripping-technique-for-gingival-depigmentation-a-clinical-and-immunohistochemical-study
#6
Gaurav Bakutra, Rajesh Shankarapillai, Lalit Mathur, Balaji Manohar
INTRODUCTION: There are various treatment modalities to remove the black patches of melanin pigmentation. The aim of the study is to clinically compare the diode laser ablation and surgical stripping technique for gingival depigmentation and to evaluate their effect on the histological changes in melanocyte activity. MATERIALS AND METHODS: A total of 40 sites of 20 patients with bilateral melanin hyperpigmentation were treated with the surgical stripping and diode laser ablation technique...
April 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28539591/characterization-of-the-adult-head-transcriptome-and-identification-of-migration-and-olfaction-genes-in-the-oriental-armyworm-mythimna-separate
#7
Hai-Xu Bian, Hong-Fang Ma, Xi-Xi Zheng, Ming-Hui Peng, Yu-Ping Li, Jun-Fang Su, Huan Wang, Qun Li, Run-Xi Xia, Yan-Qun Liu, Xing-Fu Jiang
The oriental armyworm Mythimna separate is an economically important insect with a wide distribution and strong migratory activity. However, knowledge about the molecular mechanisms regulating the physiological and behavioural responses of the oriental armyworm is scarce. In the present study, we took a transcriptomic approach to characterize the gene network in the adult head of M. separate. The sequencing and de novo assembly yielded 63,499 transcripts, which were further assembled into 46,459 unigenes with an N50 of 1,153 bp...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28538817/in-vitro-and-cellular-activities-of-the-selected-fruits-residues-for-skin-aging-treatment
#8
Nattaya Lourith, Mayuree Kanlayavattanakul, Puxvadee Chaikul, Chaisak Chansriniyom, Pichaporn Bunwatcharaphansakun
Peel extracts of litchi and rambutan, and that of tamarind seed coat were investigated in relation to their utility in skin-aging treatments. Standardized extracts of tamarind were significantly (p < 0.05) more efficient at O2 •- scavenging (IC50 = 27.44 ± 0.09) than those of litchi and rambutan (IC50 = 29.57 ± 0.30 and 39.49 ± 0.52 μg/ml, respectively) and the quercetin standard (IC50 = 31.88 ± 0.15 μg/ml). Litchi extract proved significantly (p < 0.05) more effective for elastase and collagenase inhibition (88...
May 22, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28535415/dual-hypopigmentary-effects-of-punicalagin-via-the-erk-and-akt-pathways
#9
Jun Seob Shin, Jun Hee Cho, Hana Lee, Hyo-Soon Jeong, Myo-Kyoung Kim, Hye-Young Yun, Nyoun Soo Kwon, Dong-Seok Kim
Punicalagin is a phenolic compound with antioxidant properties. However, the effects of punicalagin on melanin synthesis have been poorly evaluated. Therefore, we investigated the effects of punicalagin on melanogenesis in Mel-Ab cells. Punicalagin significantly inhibited melanin synthesis in a dose-dependent manner. In accordance with the melanin content, punicalagin also dose-dependently decreased tyrosinase activity. Punicalagin did not directly inhibit tyrosinase in a cell-free system but did downregulate the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase...
May 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28533464/the-colours-of-humanity-the-evolution-of-pigmentation-in-the-human-lineage
#10
REVIEW
Nina G Jablonski, George Chaplin
Humans are a colourful species of primate, with human skin, hair and eye coloration having been influenced by a great variety of evolutionary forces throughout prehistory. Functionally naked skin has been the physical interface between the physical environment and the human body for most of the history of the genus Homo, and hence skin coloration has been under intense natural selection. From an original condition of protective, dark, eumelanin-enriched coloration in early tropical-dwelling Homo and Homo sapiens, loss of melanin pigmentation occurred under natural selection as Homo sapiens dispersed into non-tropical latitudes of Africa and Eurasia...
July 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28533189/potential-therapeutic-effects-of-odorants-through-their-ectopic-receptors-in-pigmented-cells
#11
REVIEW
Barbara Pavan, Antonio Capuzzo, Alessandro Dalpiaz
Several olfactory receptors (ORs) have been characterized outside the olfactory neuroepithelium in neuronal and non-neuronal tissues, where they were implicated in the recognition of diverse chemical signals. ORs have been found to regulate melanogenesis in skin melanocytes, and OR expression has been found in the human brain nigrostriatal dopaminergic neurons, where production of melanin occurs as neuromelanin and can change with age; OR expression is downregulated in Parkinson's disease. Therefore, we propose several odorants as new functional ligands to ORs expressed in non-olfactory pigmented cells as dopaminergic neurons and melanocytes, where, by acting on cAMP-induced melanin production, they could help to counteract melanogenic and neurodegenerative dysfunctions, including melanoma and Parkinson's disease...
May 19, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28532039/bioactivity-mechanical-properties-and-drug-delivery-ability-of-bioactive-glass-ceramic-scaffolds-coated-with-a-natural-derived-polymer
#12
M Araújo, R Viveiros, A Philippart, M Miola, S Doumett, G Baldi, J Perez, A R Boccaccini, A Aguiar-Ricardo, E Verné
In this work, hybrid melanin-coated bioactive glass-ceramic multifunctional scaffolds were developed and characterized in terms of mechanical strength, in vitro bioactivity in simulated body fluid (SBF) and ability to load ibuprofen. The coated scaffolds exhibited an accelerated bioactivity in comparison with the uncoated ones, being able of developing hydroxyapatite-like crystals after 7days soaking in simulated body fluid (SBF). Besides its positive influence on the scaffolds bioactivity, the melanin coating was able to enhance their mechanical properties, increasing the initial compressive strength by a factor of >2...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28529514/two-rab5-homologs-are-essential-for-the-development-and-pathogenicity-of-the-rice-blast-fungus-magnaporthe-oryzae
#13
Cheng D Yang, Xie Dang, Hua W Zheng, Xiao F Chen, Xiao L Lin, Dong M Zhang, Yakubu S Abubakar, Xin Chen, Guodong Lu, Zonghua Wang, Guangpu Li, Jie Zhou
The rice blast fungus, Magnaporthe oryzae, infects many economically important cereal crops, particularly rice. It has emerged as an important model organism for studying the growth, development, and pathogenesis of filamentous fungi. RabGTPases are important molecular switches in regulation of intracellular membrane trafficking in all eukaryotes. MoRab5A and MoRab5B are Rab5 homologs in M. oryzae, but their functions in the fungal development and pathogenicity are unknown. In this study, we have employed a genetic approach and demonstrated that both MoRab5A and MoRab5B are crucial for vegetative growth and development, conidiogenesis, melanin synthesis, vacuole fusion, endocytosis, sexual reproduction, and plant pathogenesis in M...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28527391/melanin-concentrating-hormone-and-sleep
#14
REVIEW
Jozelia Gomes Pacheco Ferreira, Jackson Cioni Bittencourt, Antoine Adamantidis
The melanin-concentrating hormone (MCH) is an essential neuromodulator involved with homeostatic regulation and motivated behaviors. The majority of MCH neurons are localized within the zona incerta, lateral hypothalamic and incerto-hypothalamic areas but others regions, as the olfactory turbecle, the laterodorsal tegmental nucleus, the paramediam pontine reticular formation and the medial preoptic area, can also express the peptide depending on the gender and metabolic state of the animal. If the MCH on these novel sites of expression are also related with the control of wake-sleep cycle will be discuss in this review...
May 17, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28526633/facial-skin-rejuvenation-by-autologous-dermal-microfat-transfer-in-photoaged-patients-clinical-evaluation-and-skin-surface-digital-profilometry-analysis
#15
Angelo Trivisonno, Alfredo Rossi, Massimo Monti, Donato Di Nunno, Christophe Desouches, Claudio Cannistra, Gabriele Toietta
Cumulative long-term exposure to solar ultraviolet radiation promotes premature skin aging characterized by wrinkle formation and reduced skin elasticity. In this study, we assessed whether microfat transfer could improve dermal and subcutaneous tissue thickness loss associated with photoaging. Twenty-one patients affected by facial photoaging (photodamage grade II-IV; age range 35-62 years; 19 females, 2 males; all of Caucasian origin) were treated using minimally invasive autologous dermal white fat transfer harvested with a recently designed microcannula...
April 22, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28526553/hypothalamic-regulation-of-the-sleep-wake-cycle
#16
REVIEW
Daisuke Ono, Akihiro Yamanaka
Sleep is one of the most important physiological functions in mammals. It is regulated by not only homeostatic regulation but also circadian clock. Several neuropeptide-producing neurons located in the hypothalamus are implicated in the regulation of sleep/wakefulness. Among them, orexin/hypocretin-producing neurons (orexin neurons) are a crucial component for maintenance of wakefulness, because lack of orexin function results in narcolepsy, which is a sleep disorder. Recent findings have identified substances that excite or inhibit neural activity of orexin neurons...
May 16, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28525626/skin-pigmentation-and-risk-of-hearing-loss-in-women
#17
Brian M Lin, Wen-Qing Li, Sharon G Curhan, Konstantina M Stankovic, Abrar A Qureshi, Gary C Curhan
Black individuals have a lower risk of hearing loss than do whites, possibly because of differences in cochlear melanocytes. Previous studies have suggested that darker-skinned individuals tend to have more inner ear melanin, and cochlear melanocytes are important in generating the endocochlear potential. We investigated the relationship between self-reported hearing loss and skin pigmentation by using hair color, skin tanning ability, and skin reaction to prolonged sun exposure as surrogate measures of pigmentation among 49,323 white women in the Nurses' Health Study...
May 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28517364/a-cryptic-pigment-biosynthetic-pathway-uncovered-by-heterologous-expression-is-essential-for-conidial-development-in-pestalotiopsis-fici
#18
Peng Zhang, Xiuna Wang, Aili Fan, Yanjing Zheng, Xingzhong Liu, Shihua Wang, Huixi Zou, Berl R Oakley, Nancy P Keller, Wen-Bing Yin
Spore pigmentation is very common in the fungal kingdom. The best studied pigment in fungi is melanin which coats the surface of single cell spores. What and how pigments function in a fungal species with multiple cell conidia is poorly understood. Here, we identified and deleted a polyketide synthase (PKS) gene PfmaE and showed that it is essential for multicellular conidial pigmentation and development in a plant endophytic fungus, Pestalotiopsis fici. To further characterize the melanin pathway, we utilized an advanced Aspergillus nidulans heterologous system for the expression of the PKS PfmaE and the Pfma gene cluster...
May 18, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28515769/inhibitory-effects-of-different-fractions-of-nepeta-satureioides-on-melanin-synthesis-through-reducing-oxidative-stress
#19
Seyed Ahmad Emami, Rezvan Yazdian-Robati, Mohammad Sadeghi, Javad Baharara, Elaheh Amini, Farzaneh Salek, Zahra Tayarani-Najaran
Nepeta satureioides Boiss. has been used in traditional medicine of eastern countries and is famous for its medicinal properties. The aim of this study was to evaluate the effect of methanol (MeOH), n-hexane and dichloromethane (CH2Cl2) fractions of the extract on melanin synthesis and oxidative stress in B16F10 melanoma cell line. The B16F10 cell line viability after treatment with increasing concentrations of different fractions of the plant (5-60 μg/mL) was measured using MTT assay. The inhibitory effect on synthesis of melanin, mushroom tyrosinase activity, cellular tyrosinase and oxidative stress were determined by the colorimetric and fluorometric methods...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28515332/the-unusual-tracheal-system-within-the-wing-membrane-of-a-dragonfly
#20
Rhainer Guillermo-Ferreira, Esther Appel, Paulina Urban, Pitágoras C Bispo, Stanislav N Gorb
Some consider that the first winged insects had living tissue inside the wing membrane, resembling larval gills or developing wing pads. However, throughout the developmental process of the wing membrane of modern insects, cells and tracheoles in the lumen between dorsal and ventral cuticle disappear and both cuticles become fused. This process results in the rather thin rigid stable structure of the membrane. The herewith described remarkable case of the dragonfly Zenithoptera lanei shows that in some highly specialized wings, the membrane can still be supplemented by tracheae...
May 2017: Biology Letters
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