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https://www.readbyqxmd.com/read/29332193/melanogenesis-inhibitory-activity-of-components-from-salam-leaf-syzygium-polyanthum-extract
#1
Andriyana Setyawati, Kae Hirabayashi, Kosei Yamauchi, Hiroyuki Hattori, Tohru Mitsunaga, Irmanida Batubara, Rudi Heryanto, Hiroshi Hashimoto, Mitsuyuki Hotta
In order to identify a novel whitening agent, the methanol extract of S. polyanthum leaf was focused on by the screening test using nine Indonesian medicinal plants for the inhibition of melanogenesis and tyrosinase activity in B16 melanoma cells. Three novel compounds [(1) 1-(2,3,5-trihydroxy-4-methylphenyl)hexane-1-one, (2) 1-(2,3,5-trihydroxy methylphenyl)octane-1-one, and (3) (4E)-1-(2,3,5-trihydroxy-4-methylphenyl)decan-1-one and one known compound [(4) 1-(2,3,5-trihydroxy-4-methylphenyl)decan-1-one were isolated from the methanol extract...
January 13, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329871/isolation-of-proanthocyanidins-from-red-wine-and-their-inhibitory-effects-on-melanin-synthesis-in-vitro
#2
Takahiro Fujimaki, Shoko Mori, Manabu Horikawa, Yuko Fukui
The red wines made from Vitis vinifera were identified as skin-whitening effectors by using in vitro assays. OPCs in the wine were evaluated for tyrosinase activity and melanogenesis. Strong tyrosinase inhibitory activity was observed in fractions with high oligomeric proanthocyanidin (OPC) content. Among OPC dimers, a strong inhibitory effect on tyrosinase was observed with OPCs which contain (+)-catechin as an upper unit. Melanogenesis inhibitory effect was observed with OPCs which have (-)-epicatechin as upper units...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329224/melanin-based-functional-materials
#3
EDITORIAL
Marco d'Ischia
Melanin biopolymers are currently the focus of growing interest for a broad range of applications at the cutting edge of biomedical research and technology. This Special Issue presents a collection of papers dealing with melanin-type materials, e.g., polydopamine, for classic and innovative applications, offering a stimulating perspective of current trends in the field. Besides basic scientists, the Special Issue is directed to researchers from industries and companies that are willing to invest in melanin research for innovative and inspiring solutions...
January 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29328033/-elemental-status-of-patients-with-various-forms-of-vitiligo
#4
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, I Charischarishvili
Vitiligo is a multifactorial disease in which, in each specific case of its manifestation, different mechanisms of its pathogenesis and different levels of melanin formation in the skin can be involved. Skin is one of the most metabolically active organs. Carrying out a number of vital functions (barrier, protective, respiratory, excretory, metabolic, immune, etc.), it needs microelementss. Of the 92 naturally occurring chemical elements, 81 are found in the human body. Lack of the vital elements, leads to the emergence of diseases, which are based on deficiency, excess or imbalance of micro- and macroelements in the body...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29327028/transition-metals-and-trace-elements-in-the-retinal-pigment-epithelium-and-choroid-correlative-ultrastructural-and-chemical-analysis-by-analytical-electron-microscopy-and-nano-secondary-ion-mass-spectrometry
#5
Antje Biesemeier, Oliver Eibl, Santhana Eswara, Jean-Nicolas Audinot, Tom Wirtz, Ulrich Schraermeyer
Understanding the localisation and abundance of structural elements, trace elements and especially transition metals like Cu and Zn in ocular tissue sections is important for physiology, and also for the characterisation of diseases related to oxidative stress like age-related macular degeneration. Transition metal abundances were investigated in an aged donor eye by nano-secondary ion mass spectrometry (nano-SIMS) elemental mapping using Cs+ and O- primary ions, respectively, and correlated to their respective mole fractions investigated by analytical electron microscopy (AEM)...
January 12, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29321357/mapping-of-id-locus-for-dermal-shank-melanin-in-a-chinese-indigenous-chicken-breed
#6
Jiguo Xu, Shudai Lin, Xinfeng Gao, Qinghua Nie, Qingbin Luo, Xiquan Zhang
The dermal shank pigmentation, one of the defining traits of chicken breeds, is caused by an abnormal deposition of melanin in the dermis of the shank. The abnormal deposition is controlled by the sex-linked inhibitor of dermal melanin (Id). In this study, we aim to locate the gene responsible for the dermal shank pigmentation in chickens by an association analysis and a differential expression analysis. Based on our results, 72 single-nucleotide polymorphisms (SNPs) located in Z chromosome (chrZ): 71-73 Mb (galGal3) were selected to further explore their relationships with the dermal shank pigmentation in pure lines of 96 Gushi hens and 96 Gushi hens with a yellow shank skin colour...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29320400/posidonia-oceanica-l-delile-ethanolic-extract-modulates-cell-activities-with-skin-health-applications
#7
Laura Cornara, Giulia Pastorino, Barbara Borghesi, Annalisa Salis, Marco Clericuzio, Carla Marchetti, Gianluca Damonte, Bruno Burlando
Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activities on skin cells of an ethanolic extract obtained from the leaves of Posidonia oceanica (L.) Delile, family Potamogetonaceae, herein named Posidonia ethanolic extract (PEE). PEE showed high radical scavenging activity, high phenolic content, and resulted rich in chicoric acid, as determined through HPLC-MS analysis...
January 10, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29318654/modification-of-the-fitzpatrick-system-of-skin-phototype-classification-for-the-indian-population-and-its-correlation-with-narrowband-diffuse-reflectance-spectrophotometry
#8
V K Sharma, V Gupta, B L Jangid, M Pathak
BACKGROUND: The Fitzpatrick classification for skin phototyping is widely used, but its usefulness in dark-skinned populations has been questioned by some researchers. Recently, skin colour measurement has been proposed for phototyping skin colour objectively. AIMS: To modify the Fitzpatrick system of skin phototyping for the Indian population and to study its correlation with skin colour using narrowband diffuse reflectance spectrophotometry METHODS: Answer choices for three items (eye colour, hair colour, colour of unexposed skin) out of 10 in the original Fitzpatrick questionnaire were modified, followed by self-administration of the original and the modified Fitzpatrick questionnaire by 70 healthy Indian volunteers...
January 10, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29318595/the-early-repigmentation-pattern-of-vitiligo-is-related-to-the-source-of-melanocytes-and-by-the-choice-of-therapy-a-retrospective-cohort-study
#9
Ke Yang, Xixi Xiong, Gorkhali Pallavi, Yuting Ling, Fei Ding, Weiwei Duan, Weiling Sun, Gaozhong Ding, Qingli Gong, Wenyuan Zhu, Yan Lu
BACKGROUND: Patients with vitiligo present with different repigmentation patterns in the early recovery stage. OBJECTIVES: To analyze the relationships between early repigmentation patterns in vitiliginous patches, their clinical characteristics, and therapeutic choices. METHODS: Patients with vitiligo seen in the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University from 2010 to 2015, were included, and their clinical records, especially photographs and medical treatments, were reviewed...
January 10, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29316744/anti-pigmentation-effect-of-phellinus-linteus-fermented-eight-traditional-crude-herbalextracts-in-brown-guinea-pigsof-ultraviolet-b-uvb-induced-hyperpigmentation
#10
Hee-Young Ahn, Young-Moo Choo, Young-Su Cho
We have previously found that mycelia culture broth of eight kinds of traditional herbal extracts fermented with Phellinus linteus (previously named as 8-HsPLCB) not only inhibited melanin and tyrosinase activity, but also reduced the contents of melanogenesis-related proteins including tyrosinase and microphthalmia-associated transcription factor (MITF) in 3- isobutyl-1-methylxanthine (IBMX)-stimulated B16F0 melanoma cells. For a further study, the effect of 8-HsPLCB against skin pigmentation in brown guinea pigs of ultraviolet B (UVB)-induced hyperpigmentation was investigated...
January 11, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29316635/skin-protective-effect-of-epigallocatechin-gallate
#11
Eunji Kim, Kyeonghwan Hwang, Jongsung Lee, Sang Yun Han, Eun-Mi Kim, Junseong Park, Jae Youl Cho
Epigallocatechin gallate (EGCG) is a catechin and an abundant polyphenol in green tea. Although several papers have evaluated EGCG as a cosmetic constituent, the skin hydration effect of EGCG is poorly understood. We aimed to investigate the mechanism by which EGCG promotes skin hydration by measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression and antioxidant and anti-pigmentation properties using cell proliferation assay, Western blotting analysis, luciferase assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and reverse transcription polymerase chain reaction (RT-PCR) analysis...
January 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29315745/aspergillus-niger-mutants-affected-in-conidial-pigmentation-do-not-have-an-increased-susceptibility-to-water-stress-during-growth-at-low-water-activity
#12
Frank J J Segers, Han A B Wösten, Jan Dijksterhuis
Aspergillus niger forms conidia that contain melanin in their cell wall. This black pigment has been shown to protect fungi against UV-radiation and experimental evidence has indicated that it also protects against drought and high salt concentrations. In this study, growth of A. niger was evaluated at low water activity (aw ) and after changes in relative humidity (RH). In addition, deletion strains of A. niger affected in the melanin synthesis pathway were compared. Germination of conidia of the wild-type and deletion strains was observed at 0...
January 8, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29311485/evaluation-of-antimelanogenic-activity-and-mechanism-of-galangin-in-silico-and-in-vivo
#13
Ki Wung Chung, Hyeong Oh Jeong, Eun Kyeong Lee, Su Jeong Kim, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Abnormal pigmentation owing to excessive melanin synthesis can result in serious problems such as freckles, age-spots, and melanoma. Tyrosinase inhibitors have been an interesting target for the treatment of hyperpigmentation because tyrosinase is the rate-limiting enzyme in melanin synthesis. The screening for strong tyrosinase inhibitors led to the finding of the flavonoid galangin, which showed notable inhibitory effects on mushroom tyrosinase. The IC50 value of galangin (3.55±0.39 µM) was lower than that of kojic acid (48...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29306981/unusual-stability-of-a-recombinant-verrucomicrobium-spinosum-tyrosinase-to-denaturing-agents-and-its-use-for-a-production-of-a-protein-with-adhesive-properties
#14
A S Axambayeva, L R Zhaparova, Zh S Shagyrova, E M Ramankulov, A V Shustov
Tyrosinases catalyze oxidation of phenols with a formation of biphenols, quinones, and highly polymerized melanins. Tyrosinases have prospects for industrial use to remove phenols, also in biosensors, in bioorganic synthesis, and for a production of biocompatible adhesives (medical glues). Despite growing fields of potential applications, a selection of commercially available tyrosinases are currently limited to a single enzyme which is isolated from fruiting bodies of mushrooms. This article describes a preparation of recombinant tyrosinase from a bacterium Verrucomicrobium spinosum using a heterologous expression in Escherichia coli...
January 6, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29302212/ethyl-linoleate-inhibits-%C3%AE-msh-induced-melanogenesis-through-akt-gsk3%C3%AE-%C3%AE-catenin-signal-pathway
#15
Gyeong-A Ko, Somi Kim Cho
Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent. In this study, we investigated the effect of ethyl linoleate on the melanogenesis and the mechanism underlying its action on melanogenesis in B16F10 murine melanoma cells. Our results revealed that ethyl linoleate significantly inhibited melanin content and intracellular tyrosinase activity in α-MSH-induced B16F10 cells, but it did not directly inhibit activity of mushroom tyrosinase...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29300356/synergistic-promotion-on-tyrosinase-inhibition-by-antioxidants
#16
Yan Wang, Mi-Mi Hao, Ying Sun, Li-Feng Wang, Hao Wang, Yan-Jun Zhang, Hong-Yan Li, Peng-Wei Zhuang, Zhen Yang
When exposed to ultraviolet radiation, the human skin produces profuse reactive oxygen species (ROS), which in turn activate a variety of biological responses. Mounting ROS levels activate tyrosinase by mobilizing α-melanocyte-stimulating hormone in the epidermis and finally stimulates the melanocytes to produce melanin. Meanwhile, the Keap1-Nrf2/ARE pathway, which removes ROS, is activated at increased ROS levels, and antioxidant compounds facilitates the dissociation of Nrf2. In this study, we explored the possible suppressing effects of antioxidant compounds and tyrosine inhibitors on melanin formation and the promotory effects of these compounds on ROS scavenging...
January 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29299589/hypolipidemic-effect-and-protection-ability-of-liver-kidney-functions-of-melanin-from-lachnum-ym226-in-high-fat-diet-fed-mice
#17
Fang Shi, Jinglei Li, Liuqing Yang, Guohua Hou, Ming Ye
In the present study, we investigated the hypolipidemic properties of melanin from Lachnum YM226 (LM) in high-fat diet induced hyperlipidemic mice. After the hyperlipidemic model was established, mice were randomly divided into six groups, as follows: normal control group (NC), hyperlipidemic control group (HC), positive control group (7 mg kg-1 d-1 simvastatin) (PC) and LM groups (50, 100 and 200 mg kg-1 d-1 denoted as LM-50, LM-100 and LM-200, respectively). Subsequently, the body weight, organ indices, lipid metabolism, antioxidant properties and liver-kidney functions of the mice were examined...
January 4, 2018: Food & Function
https://www.readbyqxmd.com/read/29298480/evaluation-of-the-active-targeting-of-melanin-granules-after-intravenous-injection-of-dendronized-nanoparticles
#18
Catalina Bordeianu, Audrey Parat, Sébastien Piant, Aurélie Walter, Christine Zbaraszczuk-Affolter, Florent Meyer, Sylvie Begin-Colin, Sébastien Boutry, Robert N Muller, Elodie Jouberton, Jean-Michel Chezal, Bruno Labeille, Elisa Cinotti, Jean-Luc Perrot, Elisabeth Miot-Noirault, Sophie Laurent, Delphine Felder-Flesch
The biodistribution of dendronized iron oxides, NPs10@D1_DOTAGA and melanin-targeting NPs10@D1_ICF_DOTAGA, was studied in vivo using MRI and planar scintigraphy through [177Lu]Lu-radiolabeling. MRI experiments showed high contrast power of both dendronized nanoparticles (DPs) and hepatobiliary and urinary excretions. Little tumor uptake could be highlighted after intravenous injection probably as a consequence of the negatively charged DOTAGA-derivatized shell which reduces the diffusion across the cells' membrane...
January 4, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29297258/novel-tyrosinase-inhibitors-from-liquid-culture-of-neolentinus-lepideus
#19
Atsushi Ishihara, Yuri Ide, Tomohiro Bito, Naoki Ube, Naoki Endo, Kozue Sotome, Nitaro Maekawa, Kotomi Ueno, Akira Nakagiri
Tyrosinase is the key enzyme that controls melanin formation in the human skin. We performed a screening of 96 extracts of mushroom cultures and fruiting bodies for examining their inhibitory activity against mushroom tyrosinase. The ethyl acetate extracts of culture filtrate of Neolentinus lepideus exhibited the strongest inhibitory activity. The active compounds 1 and 2 were purified by repeated chromatographic separations from the extract. On the basis of spectroscopic analyses, 1 and 2 were identified to be 1,3-dihydroisobenzofuran-4,5,7-triol and 5-methoxy-1,3-dihydroisobenzofuran-4,7-diol, respectively...
January 3, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29296499/momentum-transfer-monte-carlo-for-the-simulation-of-laser-speckle-imaging-and-its-application-in-the-skin
#20
Caitlin Regan, Carole Hayakawa, Bernard Choi
Due to its simplicity and low cost, laser speckle imaging (LSI) has achieved widespread use in biomedical applications. However, interpretation of the blood-flow maps remains ambiguous, as LSI enables only limited visualization of vasculature below scattering layers such as the epidermis and skull. Here, we describe a computational model that enables flexible in-silico study of the impact of these factors on LSI measurements. The model uses Monte Carlo methods to simulate light and momentum transport in a heterogeneous tissue geometry...
December 1, 2017: Biomedical Optics Express
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