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Childhood obesity

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https://www.readbyqxmd.com/read/27926527/meqtl-analysis-of-childhood-obesity-links-epigenetics-with-a-risk-snp-rs17782313-near-mc4r-from-meta-analysis
#1
Yuping Tang, Bo Jin, Lingling Zhou, Weifeng Lu
Earlier GWAS has identified that rs17782313 near MC4R was associated with obesity. However, subsequent studies showed conflicting results, especially among childhood. Besides, the mechanisms underlying the association between rs17782313 and childhood obesity remain largely unexplored, and genetic and epigenetic may interact and together affect the development of childhood obesity. We conducted a comprehensive meta-analysis to assess the association between rs17782313 and childhood obesity. MeQTL and eQTL analysis was applied to explore the effect of rs17782313 on DNA methylation and MC4R expression...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925457/now-is-the-time-to-improve-access-and-healthcare-systems-for-childhood-obesity-treatment
#2
Robert I Berkowitz, Stephen Daniels
No abstract text is available yet for this article.
December 7, 2016: Obesity
https://www.readbyqxmd.com/read/27925451/improving-access-and-systems-of-care-for-evidence-based-childhood-obesity-treatment-conference-key-findings-and-next-steps
#3
REVIEW
Denise E Wilfley, Amanda E Staiano, Myra Altman, Jeanne Lindros, Angela Lima, Sandra G Hassink, William H Dietz, Stephen Cook
OBJECTIVE: To improve systems of care to advance implementation of the U.S. Preventive Services Task Force recommendations for childhood obesity treatment (i.e., clinicians offer/refer children with obesity to intensive, multicomponent behavioral interventions of >25 h over 6 to 12 months to improve weight status) and to expand payment for these services. METHODS: In July 2015, 43 cross-sector stakeholders attended a conference supported by the Agency for Healthcare Research and Quality, American Academy of Pediatrics Institute for Healthy Childhood Weight, and The Obesity Society...
December 7, 2016: Obesity
https://www.readbyqxmd.com/read/27923861/critical-stakeholder-determinants-to-the-implementation-of-intersectoral-community-approaches-targeting-childhood-obesity
#4
R M J J van der Kleij, M R Crone, R Reis, T G W M Paulussen
Several intersectoral community approaches targeting childhood obesity (IACOs) have been launched in the Netherlands. Translation of these approaches into practice is however arduous and implementation. We therefore studied the implementation of five IACOs in the Netherlands for one-and-a-half years. IACO implementation was evaluated via an adapted version of the MIDI questionnaire, consisting of 18 theory-based constructs. A response rate of 62% was obtained. A hierarchical multivariate linear regression model was used to analyse our data; the final regression model predicted 65% of the variance in adherence...
December 2016: Health Education Research
https://www.readbyqxmd.com/read/27923101/secular-changes-in-physical-growth-and-obesity-among-southwestern-american-indian-children-over-four-decades
#5
P Vijayakumar, K M Wheelock, S Kobes, R G Nelson, R L Hanson, W C Knowler, M Sinha
BACKGROUND AND OBJECTIVES: Most studies describing childhood obesity in the United States are based on cross-sectional surveys and do not include substantial numbers of American Indians (AI). Secular trends in height and weight reflect general health status. This study describes weight trends and transitions among AI children over a 43-year period. METHODS: Anthropometric data were obtained from a prospective study conducted in a southwestern US AI population (1965 through 2007)...
December 6, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27923099/cesarean-birth-is-not-associated-with-early-childhood-body-mass-index
#6
L G Smithers, B W Mol, L Jamieson, J W Lynch
Cesarean birth leads to a markedly different microbiome compared to vaginal birth, and the microbiome has been implicated in childhood obesity. Among mothers who had a previous cesarean, we compared anthropometry of 3- to 6-year-old children who were subsequently born by cesarean section versus vaginal birth. This large population-based study involved linking de-identified administrative perinatal and anthropometric data. Children's weight and height were collected at community-based clinics and converted to age- and sex-adjusted z-scores of height-for-age (HFAz), weight-for-age (WFAz) and BMI-for-age (BMIz)...
December 6, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27922238/parental-perception-and-child-s-nutritional-status
#7
S Songül Yalçın, Esra Serdaroğlu, O Tolga İnce
Childhood obesity is a health hazard increasing worldwide. Preschool period which is under supervision of parents is a critical period to detect overweight and take precautions. We studied the factors affecting parental estimation of their preschool child's weight. Three hundred sixty seven mothers completed questionnaires consisting of child's and parents' anthropometric measurements, parents' assessment of their child's and their own weight status, and general information about their lifestyle. Mothers also chose their wish for current and future body image of their child from child drawings representing percentiles...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27921200/testing-an-integrated-model-of-program-implementation-the-food-health-choices-school-based-childhood-obesity-prevention-intervention-process-evaluation
#8
Marissa Burgermaster, Heewon Lee Gray, Elizabeth Tipton, Isobel Contento, Pamela Koch
Childhood obesity is a complex, worldwide problem. Significant resources are invested in its prevention, and high-quality evaluations of these efforts are important. Conducting trials in school settings is complicated, making process evaluations useful for explaining results. Intervention fidelity has been demonstrated to influence outcomes, but others have suggested that other aspects of implementation, including participant responsiveness, should be examined more systematically. During Food, Health & Choices (FHC), a school-based childhood obesity prevention trial designed to test a curriculum and wellness policy taught by trained FHC instructors to fifth grade students in 20 schools during 2012-2013, we assessed relationships among facilitator behaviors (i...
December 5, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27916426/high-body-mass-index-in-infancy-may-predict-severe-obesity-in-early-childhood
#9
Allison Smego, Jessica G Woo, Jillian Klein, Christina Suh, Danesh Bansal, Sherri Bliss, Stephen R Daniels, Christopher Bolling, Nancy A Crimmins
OBJECTIVE: To characterize growth trajectories of children who develop severe obesity by age 6 years and identify clinical thresholds for detection of high-risk children before the onset of obesity. STUDY DESIGN: Two lean (body mass index [BMI] 5th to ≤75th percentile) and 2 severely obese (BMI ≥99th percentile) groups were selected from populations treated at pediatric referral and primary care clinics. A population-based cohort was used to validate the utility of identified risk thresholds...
December 2, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27916004/sugars-and-health-a-review-of-current-evidence-and-future-policy
#10
Charlotte Elizabeth Louise Evans
The automation of the process of extracting sugars in the 1900s reduced cost and increased availability of sugars leading to a dramatic rise in consumption, which reached a peak in the 1970s. There are different definitions for sugars not naturally available in foods, and free sugars is the term used by WHO. The epidemiological evidence of the associations between sugars and obesity and type 2 diabetes mellitus is fairly strong and consistent, particularly for sugar sweetened drinks in adults. The Department of Health in the UK and many other countries have recently updated their recommendations for free sugars as a result of this scientific evidence...
December 5, 2016: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/27915138/parental-misclassification-of-child-overweight-obese-status-the-role-of-parental-education-and-parental-weight-status
#11
John Cullinan, John Cawley
Childhood overweight and obesity is a major public health challenge for policymakers in many countries. As the most common supervisors of children's activities, parents have a potentially important role to play in obesity prevention. However, a precondition for parents to improve their children's diets, encourage them to be more physically active, or take them to see a doctor about their weight is for the parent to first recognize that their child is overweight or obese. This paper examines the extent of parental misclassification of child weight status, and its correlates, focusing on the role of parental education and the parent's own obesity status...
November 17, 2016: Economics and Human Biology
https://www.readbyqxmd.com/read/27914588/obesity-in-pediatric-trauma
#12
Cordelie E Witt, Saman Arbabi, Avery B Nathens, Monica S Vavilala, Frederick P Rivara
BACKGROUND/PURPOSE: The implications of childhood obesity on pediatric trauma outcomes are not clearly established. Anthropomorphic data were recently added to the National Trauma Data Bank (NTDB) Research Datasets, enabling a large, multicenter evaluation of the effect of obesity on pediatric trauma patients. METHODS: Children ages 2 to 19years who required hospitalization for traumatic injury were identified in the 2013-2014 NTDB Research Datasets. Age and gender-specific body mass indices (BMI) were calculated...
November 23, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27913907/development-of-a-culturally-informed-child-safety-curriculum-for-american-indian-families
#13
Ryan M Berns, Emily J Tomayko, Kate A Cronin, Ronald J Prince, Tassy Parker, Alexandra K Adams
American Indian (AI) children are disproportionately affected by unintentional injuries, with injury mortality rates approximately 2.3 times higher than the combined rates for all children in the United States. Although multiple risk factors are known to contribute to these increased rates, a comprehensive, culturally informed curriculum that emphasizes child safety is lacking for this population. In response to this need, academic and tribal researchers, tribal community members, tribal wellness staff, and national child safety experts collaborated to develop a novel child safety curriculum...
December 2, 2016: Journal of Primary Prevention
https://www.readbyqxmd.com/read/27913605/non-alcoholic-fatty-liver-disease-is-associated-with-early-left-ventricular-dysfunction-in-childhood-acute-lymphoblastic-leukaemia-survivors
#14
Maurizio Delvecchio, Paola Muggeo, Mariantonietta Monteduro, Giuseppe Lassandro, Chiara Novielli, Federica Valente, Emanuela Salinaro, Annapaola Zito, Marco Matteo Ciccone, Vito Leonardo Miniello, Nicola Santoro, Paola Giordano, Maria Felicia Faienza
BACKGROUND: Childhood acute lymphoblastic leukaemia (ALL) survivors have an increased risk of metabolic and cardiovascular disease. We aimed to assess the presence of non-alcoholic fatty liver disease (NAFLD) in childhood ALL and if it is associated with early cardiovascular dysfunction. METHODS: In total, 53 childhood ALL survivors and 34 controls underwent auxological evaluation, biochemical assay, liver, heart and vascular ultrasound study. RESULTS: NAFLD was more frequent in ALL patients than in controls (39...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27912924/obesity-as-a-mediator-between-cardiorespiratory-fitness-and-blood-pressure-in-preschoolers
#15
Diana P Pozuelo-Carrascosa, Mairena Sánchez-López, Iván Cavero-Redondo, Ana Torres-Costoso, Alberto Bermejo-Cantarero, Vicente Martínez-Vizcaíno
OBJECTIVES: To analyze the relationships between body mass index (BMI), cardiorespiratory fitness (CRF), and blood pressure (BP), and to examine whether obesity acts as a mediator between fitness and BP in children. STUDY DESIGN: A cross-sectional analysis using a population-based sample of 1604 school children aged 4-7 years attending 21 schools from the provinces of Ciudad Real and Cuenca, Spain, was undertaken. Data on anthropometric variables, BP measurements, and CRF were collected...
November 29, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27912741/impact-of-a-school-based-intervention-on-nutritional-education-and-physical-activity-in-primary-public-schools-in-chile-kind-programme-study-protocol-cluster-randomised-controlled-trial
#16
Nelly Bustos, Sonia Olivares, Bárbara Leyton, Marcelo Cano, Cecilia Albala
BACKGROUND: Chile has suffered a fast increase in childhood obesity in the last 10 years. As a result, several school programmes have been implemented, however the effectiveness of these needs to be evaluated to identify and prioritize strategies to curve this trend. METHODS: Cluster randomized controlled trial. Twelve primary public schools chosen at random over three regions of the country will take part in this study. The sample size consisted of a total of 1,655 children...
December 3, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27911984/home-visitation-programs-an-untapped-opportunity-for-the-delivery-of-early-childhood-obesity-prevention
#17
S-J Salvy, K de la Haye, T Galama, M I Goran
BACKGROUND: Extant obesity efforts have had limited impact among low-income underserved children, in part because of limitations inherent to existing programs: (i) short duration and low intensity; (ii) late timing of implementation, when children are already overweight or obese; (iii) intervention delivery limiting their accessibility and sustainability; and (iv) failure to address barriers such as a lack of culturally competent services, poverty and housing instability, which interfere with healthy lifestyle changes...
December 2, 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27909901/obesity-and-breast-cancer
#18
Renée T Fortner, Verena Katzke, Tilman Kühn, Rudolf Kaaks
The relationship between adiposity and breast cancer risk and prognosis is complex, with associations that differ depending on when body size is assessed (e.g., pre- vs. postmenopausal obesity) and when breast cancer is diagnosed (i.e., pre- vs. postmenopausal disease). Further, the impact of obesity on risk differs by tumor hormone receptor status (e.g., estrogen (ER) and progesterone (PR) receptor) and, among postmenopausal women, use of exogenous hormones (i.e., hormone replacement therapy (HRT)). In the context of these complexities, this review focuses on associations between childhood and adolescent adiposity, general adiposity, weight changes (i...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27909900/obesity-and-colorectal-cancer
#19
Carmen Jochem, Michael Leitzmann
There is strong evidence that modifiable lifestyle factors such as obesity play a key role in colorectal carcinogenesis. Epidemiologic data have consistently reported a positive association between obesity and colorectal cancer. The relative risk associated with general obesity (as assessed by BMI) is higher in men than in women and for cancer of the colon than for cancer of the rectum. Abdominal obesity (as assessed by waist circumference (WC) or waist-to-hip ratio) is associated with an increased risk of colorectal cancer in both sexes, with stronger associations for cancer of the colon than for cancer of the rectum...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27909843/increased-risk-of-large-for-gestational-age-birthweight-in-singleton-siblings-conceived-with-in-vitro-fertilization-in-frozen-versus-fresh-cycles
#20
Barbara Luke, Morton B Brown, Ethan Wantman, Judy E Stern, James P Toner, Charles C Coddington
BACKGROUND: Children born from fresh in vitro fertilization (IVF) cycles are at greater risk of being born smaller and earlier, even when limited to singletons; those born from frozen cycles have an increased risk of large-for-gestational age (LGA) birthweight (z-score ≥1.28). This analysis sought to overcome limitations in other studies by using pairs of siblings, and accounting for prior cycle outcomes, maternal characteristics, and embryo state and stage. METHODS: Pairs of singleton births conceived with IVF and born between 2004 and 2013 were identified from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database, matched for embryo stage (blastocyst versus non-blastocyst) and infant gender, categorized by embryo state (fresh versus frozen) in 1st and 2nd births (four groups)...
December 1, 2016: Journal of Assisted Reproduction and Genetics
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