Ashraf B Abdel-Naim, Abdullah A Alghamdi, Mardi M Algandaby, Fahad A Al-Abbasi, Ahmed M Al-Abd, Hossam M Abdallah, Ali M El-Halawany, Masao Hattori
Osteoporosis is a serious health problem characterized by decreased bone mineral density and deterioration of bone microarchitecture. Current antiosteoporotic agents exhibit a wide range of adverse effects; meanwhile, phytochemicals are effective and safer alternatives. In the current work, nine compounds belonging to hydroxyphenylalkane and diarylheptanoid groups were isolated from Aframomum meleguea seeds and identified as 6-gingerol ( 1 ), 6-paradol ( 2 ), 8-dehydrogingerdione ( 3 ), 8-gingerol ( 4 ), dihydro-6-paradol ( 5 ), dihydrogingerenone A ( 6 ), dihydrogingerenone C ( 7 ), 1,7-bis(3,4-dihydroxy-5-methoxyphenyl)heptane-3,5-diyl diacetate ( 8 ), and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(3,4-dihydroxyphenyl)heptane-3,5-diyl diacetate ( 9 )...
September 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry