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https://www.readbyqxmd.com/read/28749236/are-males-and-females-with-autism-spectrum-disorder-more-similar-than-we-thought
#1
Joanna L Mussey, Nicole C Ginn, Laura G Klinger
Differences in behavioral and cognitive profiles have been suggested to potentially impact the presentation of social and communication symptoms in females with autism spectrum disorder. This study examined gender differences in age of diagnosis, cognitive profiles, social communication symptomatology, and autism spectrum disorder symptom severity in a community-based sample of 566 males and 113 females with autism spectrum disorder ranging in age from 1 year, 9 months to 56 years, 4 months. Results suggest either very small or no gender differences in age at diagnosis, intelligence quotient, cognitive profiles, or autism spectrum disorder symptom severity...
August 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28746075/fatigue-in-residency-education-understanding-the-influence-of-work-hours-regulations-in-europe
#2
Taryn S Taylor, Pim W Teunissen, Tim Dornan, Lorelei Lingard
PURPOSE: Although one proposed solution to the problem of fatigued medical trainees is the implementation of work hours regulations, concerns about the effectiveness of these regulations are growing. Canada remains one of the few Western jurisdictions without legislated regulation. Recent research suggests that fatigue is a complex social construct, rather than simply a lack of sleep; thus, the authors explored how regulations and fatigue are understood in countries with established work hours frameworks to better inform other jurisdictions looking to address trainee fatigue...
July 25, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28743852/-new-methods-for-the-evaluation-of-bone-quality-bone-quality-marker
#3
Masakazu Miura, Yuki Satoh
In recent years, undercarboxylated osteocalcin(ucOC), advanced glycation endproducts(AGEs)and homocysteine are attracting attention as factors defining bone strength. However, there are still many problems in its measurement, and it has not yet been routinely used in clinical practice. If solving the problem in the future, it is expected that the utility on bone quality will also increase.
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28741758/stem-cell-derived-exosomes-a-promising-strategy-for-fracture-healing
#4
REVIEW
Zi-Chen Hao, Jun Lu, Shan-Zheng Wang, Hao Wu, Yun-Tong Zhang, Shuo-Gui Xu
OBJECTIVES: To describe the biological characteristics of exosomes and to summarize the current status of stem cell-derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed. METHODS: Search and analyze the related articles in pubmed database through the multi-combination of keywords like "stem cells","exosomes","bone regeneration" and "fracture healing". CONCLUSION: Stem cell-derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention...
July 25, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28741419/measuring-and-diagnosing-unilateral-neglect-a-standardized-statistical-procedure
#5
Alessio Toraldo, Cristian Romaniello, Paolo Sommaruga
OBJECTIVE: Unilateral neglect is usually investigated by adminstering stimuli (targets) in different positions, with targets being responded to by the patient (Hit) or omitted. In spite of this homogeneity of data type, neglect indices and diagnostic criteria vary considerably, causing inconsistencies in both clinical and experimental settings. We aimed at deriving a standard analysis which would apply to all tasks sharing this data form. METHODS: A-priori theoretical reasoning demonstrated that the mean position of Hits in space (MPH) is an optimal index for correctly diagnosing and quantifying neglect...
July 25, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28741130/epigenetic-involvement-in-etiopathogenesis-and-implications-in-treatment-of-systemic-lupus-erythematous
#6
REVIEW
Arron Munggela Foma, Saeed Aslani, Jafar Karami, Ahmadreza Jamshidi, Mahdi Mahmoudi
BACKGROUND: Recent researches in the field of genetics have extended our knowledge through the discovery of genetic factors associated with autoimmune diseases (AID). Genetics by itself, however, cannot elucidate all the uncertainties encountered in the etiopathology of AID. On the other hand, incomplete harmony in the prevalence of AID in identical twins suggests that non-genetic factors may play an important role in determining the disease susceptibility. Besides, epigenetics, which is defined by changes in gene expression without a corresponding change in the DNA sequences, has come in to provide new awareness in the disease etiopathology by bridging the genetic and epigenetic factors...
July 24, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28739272/an-on-line-analytical-approach-for-detecting-haptens-in-shuang-huang-lian-powder-injection
#7
Hong Wang, Xiaotian Zhang, Daidong Wang, Hongyang Sun, Yuexiang Lan, Haixiu Jiang, Shizhong Chen, Zongtao Lin
Shuang-huang-lian powder injection (SHLPI) is a traditional Chinese medicine injection (TCMI) frequently used in the clinical treatment of faucitis, bronchitis, and other viral and bacterial infections of upper respiratory tract. However, its allergenic reactions, being the main adverse effects (AEs) of SHLPI, have been a serious problem of its clinical safety. This problem has not been solved due to short of methods for detecting haptens in complex TCMIs. In this study, an on-line high-performance liquid chromatography-diode-array detector-mass spectrometry combined with bovine serum albumin-fluorescence detector (HPLC-DAD-MS-BSA-FLD) system was established for the first time, validated and applied for identification of haptens in SHLPI...
July 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28727134/biological-markers-with-potential-clinical-value-in-endometrial-cancer-review-of-the-literature
#8
Nadia Taoussi, Ali Alghamdi, Konrad Futyma, Tomasz Rechberger
Endometrial carcinoma (EC) is the most common malignancy of the female genital tract encountered in western countries, making it the fourth most common cancer in women. The incidence of uterine cancer is on the rise throughout the developed world where diagnosis is increasingly observed among younger patients. With regard to this, attention has been focused on conducting more studies to achieve a better understanding of the molecular genetics related to endometrial carcinogenesis. Over the years, EC has been classified into two broad histopathological subtypes based on the mechanism of development, and we can therefore observe specific biomarkers related to the respective subtype...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28725145/hiv-pharmaceutical-care-in-primary-healthcare-improvement-in-cd4-count-and-reduction-in-drug-related-problems
#9
C G R C Molino, Renata Cavalcanti Carnevale, Aline Teotonio Rodrigues, Patricia Moriel, Priscila Gava Mazzola
Background: Highly active antiretroviral therapy (HAART) is complex and many factors contribute to a patient's response to initial therapy including adherence, drug effectiveness, and tolerance. Close HAART follow-up is needed, particularly when there are concurrent therapies such as prophylactic antibiotics and medications for the treatment of comorbidities. Objective: To assess the effectiveness of pharmacist intervention in reducing drug related problems in HIV/AIDS outpatients (intervention group) and in improving clinical parameters in the intervention group compared to the control group...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28724914/enhanced-learning-through-multimodal-training-evidence-from-a-comprehensive-cognitive-physical-fitness-and-neuroscience-intervention
#10
N Ward, E Paul, P Watson, G E Cooke, C H Hillman, N J Cohen, A F Kramer, A K Barbey
The potential impact of brain training methods for enhancing human cognition in healthy and clinical populations has motivated increasing public interest and scientific scrutiny. At issue is the merits of intervention modalities, such as computer-based cognitive training, physical exercise training, and non-invasive brain stimulation, and whether such interventions synergistically enhance cognition. To investigate this issue, we conducted a comprehensive 4-month randomized controlled trial in which 318 healthy, young adults were enrolled in one of five interventions: (1) Computer-based cognitive training on six adaptive tests of executive function; (2) Cognitive and physical exercise training; (3) Cognitive training combined with non-invasive brain stimulation and physical exercise training; (4) Active control training in adaptive visual search and change detection tasks; and (5) Passive control...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28722038/promises-facts-and-challenges-for-graphene-in-biomedical-applications
#11
Giacomo Reina, José Miguel González-Domínguez, Alejandro Criado, Ester Vázquez, Alberto Bianco, Maurizio Prato
The graphene family has captured the interest and the imagination of an increasing number of scientists working in different fields, ranging from composites to flexible electronics. In the area of biomedical applications, graphene is especially involved in drug delivery, biosensing and tissue engineering, with strong contributions to the whole nanomedicine area. Besides the interesting results obtained so far and the evident success, there are still many problems to solve, on the way to the manufacturing of biomedical devices, including the lack of standardization in the production of the graphene family members...
July 19, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28720581/hit-ndrive-patient-specific-multi-driver-gene-prioritization-for-precision-oncology
#12
Raunak Shrestha, Ermin Hodzic, Thomas Sauerwald, Phuong Dao, Kendric Wang, Jake Yeung, Shawn Anderson, Fabio Vandin, Gholamreza Haffari, Colin C Collins, Cenk Sahinalp
Prioritizing molecular alterations that act as drivers of cancer remains a crucial bottleneck in therapeutic development. Here we introduce HIT'nDRIVE, a computational method that integrates genomic and transcriptomic data to identify a set of patient-specific, sequence-altered genes, with sufficient collective influence over dysregulated transcripts. HIT'nDRIVE aims to solve the "random walk facility location" (RWFL) problem in a gene (or protein) interaction network, which differs from the standard facility location problem by its use of an alternative distance measure: "multi-hitting time", the expected length of the shortest random walk from any one of the set of sequence-altered genes to an expression-altered target gene...
July 18, 2017: Genome Research
https://www.readbyqxmd.com/read/28720092/a-qualitative-study-of-clinic-and-community-member-perspectives-on-intervention-toolkits-unless-the-toolkit-is-used-it-won-t-help-solve-the-problem
#13
Melinda M Davis, Sonya Howk, Margaret Spurlock, Paul B McGinnis, Deborah J Cohen, Lyle J Fagnan
BACKGROUND: Intervention toolkits are common products of grant-funded research in public health and primary care settings. Toolkits are designed to address the knowledge translation gap by speeding implementation and dissemination of research into practice. However, few studies describe characteristics of effective intervention toolkits and their implementation. Therefore, we conducted this study to explore what clinic and community-based users want in intervention toolkits and to identify the factors that support application in practice...
July 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28719151/staged-treatment-in-early-psychosis-a-sequential-multiple-assignment-randomised-trial-of-interventions-for-ultra-high-risk-of-psychosis-patients
#14
REVIEW
Barnaby Nelson, G Paul Amminger, Hok Pan Yuen, Nicky Wallis, Melissa J Kerr, Lisa Dixon, Cameron Carter, Rachel Loewy, Tara A Niendam, Martha Shumway, Sarah Morris, Julie Blasioli, Patrick D McGorry
AIM: Previous research indicates that preventive intervention is likely to benefit patients "at risk" of psychosis, in terms of functional improvement, symptom reduction and delay or prevention of onset of threshold psychotic disorder. The primary aim of the current study is to test outcomes of ultra high risk (UHR) patients, primarily functional outcome, in response to a sequential intervention strategy consisting of support and problem solving (SPS), cognitive-behavioural case management and antidepressant medication...
July 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28717981/effects-of-counselling-on-adherence-to-antiretroviral-treatment-among-people-with-hiv-in-estonia-a-randomized-controlled-trial
#15
Anneli Uusküla, Kaja-Triin Laisaar, Mait Raag, Liis Lemsalu, Liilia Lõhmus, Kristi Rüütel, K Rivet Amico
To assess the efficacy of an education- and strengths-based counselling programme to promote antiretroviral therapy (ART) adherence in a cohort of HIV-infected individuals with high prevalence of injection drug use in Estonia. Parallel-group randomized (1:1) controlled trial (RCT). Adults receiving ART in two clinics were followed for 12 months. The trial compared: (i) an intervention (three sessions) incorporated into routine clinic visits, providing education about HIV, ART, the role of adherence, and tailoring regimen to daily routines using problem-solving skills to address adherence barriers versus (ii) usual care (control)...
July 17, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28716130/psychometric-properties-and-relations-with-coping-and-family-strain-of-the-health-services-and-caregiver-experience-questionnaire-hsce-an-outcome-measure-of-informal-caregivers-experience-for-inpatient-care-in-italy
#16
Anna Coluccia, Fabio Ferretti, Andrea Fagiolini, Andrea Pozza
BACKGROUND: In the last decade, the number of patients supported by informal caregivers has substantially increased. In the Italian healthcare context, informal caregivers' experience of care is a new under-recognized construct, and no assessment tool is available. Measuring caregivers' experience is important since in Italy the relationship between doctors and patients/relatives is still considered asymmetrical. The current study presented development and initial psychometric properties of the Health Services and Caregiver Experience questionnaire (HSCE), a self-report tool of caregivers' global experience for inpatient clinical care, including factor structure, reliability and its relations with measures of coping strategies and family strain...
July 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28713072/link-worker-social-prescribing-to-improve-health-and-well-being-for-people-with-long-term-conditions-qualitative-study-of-service-user-perceptions
#17
Suzanne Moffatt, Mel Steer, Sarah Lawson, Linda Penn, Nicola O'Brien
OBJECTIVES: To describe the experiences of patients with long-term conditions who are referred to and engage with a Link Worker social prescribing programme and identify the impact of the Link Worker programme on health and well-being. DESIGN: Qualitative study using semistructured interviews with thematic analysis of the data. INTERVENTION: Link Worker social prescribing programme comprising personalised support to identify meaningful health and wellness goals, ongoing support to achieve agreed objectives and linkage into appropriate community services...
July 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28711750/web-based-tailored-psycho-education-for-breast-cancer-patients-at-the-onset-of-the-survivorship-phase-a-multicenter-randomized-controlled-trial
#18
Jolien M Admiraal, Annette W G van der Velden, Jenske I Geerling, Johannes G M Burgerhof, Grietje Bouma, Annemiek M E Walenkamp, Elisabeth G E de Vries, Carolien P Schröder, Anna K L Reyners
CONTEXT: Many breast cancer patients have unmet informational and psychosocial needs after treatment completion. A psycho-educational intervention may be well-suited to support these patients. OBJECTIVES: The purpose of this multicenter randomized controlled trial was to examine the effectiveness of a web-based tailored psycho-educational program (ENCOURAGE) for breast cancer patients which aims to empower patients to take control over prevailing problems. METHODS: Female breast cancer patients from two hospitals in the Netherlands who recently completed (neo-)adjuvant chemotherapy were randomly assigned to standard care or 12-week access to the ENCOURAGE program providing fully automated information, problem-solving strategies, resources and services for reported problems...
July 12, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28708632/innovating-with-rehabilitation-technology-in-the-real-world-promises-potentials-and-perspectives
#19
Karen Sui Geok Chua, Christopher Wee Keong Kuah
In this article, we discuss robotic-assisted therapy as an emerging and significant field of clinical rehabilitation and its value proposition for innovating rehabilitation clinical practice. Attempts to achieve integration among clinicians' practices and bioengineers' machines often generate new challenges and controversies. To date, the literature is indicative of a sizeable number and variety of robotic devices in the field of clinical rehabilitation, some are commercially available; however, large-scale clinical outcomes are less positive than expected...
July 13, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28707137/surface-modification-of-esophageal-stent-materials-by-a-polyethylenimine-layer-aiming-at-anti-cancer-function
#20
Kun Zhang, Yuxin Bai, Xiaofeng Wang, Qian Li, Fangxia Guan, Jingan Li
Esophageal cancer is difficult to cure globally and possesses high mortality rate, and it is generally accepted that palliative care such as stent implantation is the main therapy method for esophageal cancer in later period. However, the restenosis caused by tumor cells and inflammatory cells seriously interferes the stent clinical application and limits its long-term services. To solve this problem, series of drug delivery stents were developed and proven rather effective in the early stage of implantation, but more serious restenosis occurred after the drug delivery was over, which endangered the patients' life...
August 2017: Journal of Materials Science. Materials in Medicine
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