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https://www.readbyqxmd.com/read/28647714/the-burden-of-multiple-sclerosis-and-patients-coping-strategies
#1
Lorena Lorefice, Giuseppe Fenu, Jessica Frau, Giancarlo Coghe, Maria Giovanna Marrosu, Eleonora Cocco
OBJECTIVES: Multiple sclerosis (MS) is a chronic disease that mainly affects young people. Patients with MS experience several emotional responses to changed perceptions of themselves and manage this situation in ways focused on controlling the overall burden of disease. This present study aimed to evaluate differences between patients with MS and healthy controls (HCs) in coping styles, identifying the MS clinical features that influence adaptive responses. METHODS: Patients with MS, according to the McDonald 2010 criteria, and HCs were recruited...
June 24, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28645961/cognitive-screening-and-behavioural-observation-of-functional-ability-in-patients-with-multiple-episode-schizophrenia-an-exploratory-study
#2
Eva Norlin Bagge, Eva Esbjörnsson, Katharina S Sunnerhagen
OBJECTIVES: To evaluate the usability of a neuropsychological screening instrument and two observation scales of everyday behaviour to describe cognitive and functional capacity of patients with multiepisode schizophrenia and considerable care needs, who frequently refuse to participate in cognitive testing or performance-based functional measurement. SETTING: One psychiatric unit specialised in severe mental illness at the Sahlgrenska University Hospital, Gothenburg, Sweden...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28644430/the-clinical-landscape-for-sma-in-a-new-therapeutic-era
#3
REVIEW
K Talbot, E F Tizzano
Despite significant advances in basic research, the treatment of degenerative diseases of the nervous system remains one of the greatest challenges for translational medicine. The childhood onset motor neuron disorder spinal muscular atrophy (SMA) has been viewed as one of the more tractable targets for molecular therapy, due to a detailed understanding of the molecular genetic basis of the disease. In SMA, inactivating mutations in the SMN1 gene can be partially compensated for by limited expression of SMN protein from a variable number of copies of the SMN2 gene, which provides both a molecular explanation for phenotypic severity and a target for therapy...
June 23, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28641984/bi-objective-approach-for-placing-ground-and-air-ambulance-base-and-helipad-locations-in-order-to-optimize-ems-response
#4
Milad Shahriari, Ali Bozorgi-Amiri, Shayan Tavakoli, Abolghasem Yousefi-Babadi
Shortening the travel time of patient transfer has clinical implications for many conditions such as cardiac arrest, trauma, stroke and STEMI. As resources are often limited precise calculations are needed. In this paper we consider the location problem for both ground and aerial emergency medical services. Given the uncertainty of when patients are in need of prompt medical attention we consider these demand points to be uncertain. We consider various ways in which ground and helicopter ambulances can work together to make the whole process go faster...
June 15, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28641249/eit-imaging-regularization-based-on-spectral-graph-wavelets
#5
Bo Gong, Benjamin Schullcke, Sabine Krueger-Ziolek, Marko Vauhkonen, Gerhard Wolf, Ullrich Mueller-Lisse, Knut Moeller
The objective of Electrical Impedance Tomographic reconstruction is to identify the distribution of tissue conductivity from electrical boundary conditions. This is an ill-posed inverse problem usually solved under the finite element method framework. In previous studies, standard sparse regularization was used for difference EIT to achieve a sparse solution. However, regarding element-wise sparsity, standard sparse regularization interferes with the smoothness of conductivity distribution between neighboring elements and is sensitive to noise...
June 16, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28635905/-algorithm-for-the-management-of-patients-with-stable-coronary-artery-disease-and-high-grade-ventricular-arrhythmias
#6
Е А Ryngach, T V Treshkur, A A Tatarinova, E V Shlyakhto
The paper gives an original algorithm for the management of patients with stable coronary artery disease, preserved/moderately reduced left ventricular systolic function, and high-grade ventricular arrhythmias from the first registration of the latter to the choice of treatment policy. Great attention is paid to the assessment of a private clinical case, by determining the nature of arrhythmias, and to the involvement of autonomic regulation in the genesis of ventricular arrhythmias. The importance of topical diagnosis of ventricular arrhythmias and identification of psychological disorders is emphasized...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28631900/-experimental-development-and-rationale-for-a-renal-decellularization-protocol-with-subsequent-comprehensive-assessment-of-the-biological-scaffold
#7
P V Glybochko, S N Alekseenko, E A Gubareva, E V Kuevda, A A Basov, A S Sotnichenko, S S Dzhimak, I S Gumenyuk, I Kh Egiev, V N Chechelyan, R Z Nakokhov, O M Lyasota, Yu V Teterin
Chronic renal failure (CRF) is one of the most challenging problems of contemporary medicine. Patients with chronic renal failure usually need renal replacement therapy as either hemodialysis, peritoneal dialysis or a kidney transplant. The latter is the most promising option for end-stage kidney disease. However, the shortage of donor organs, the complexity of their delivery, the difficulty in finding an immunologically compatible donor and the need for lifelong immunosuppression triggered advances in modern tissue engineering...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28631640/concept-map-as-an-adjunct-tool-to-teach-pathology
#8
Shivayogi R Bhusnurmath, Bharti Bhusnurmath, Shefali Goyal, Safina Hafeez, Ashraf Abugroun, John Okpe
CONTEXT: Concept maps (CMs) were tested for their effectiveness in teaching pathology in a conceptual manner. AIMS: To correlate the quality of CMs drawn by students with their performance on tests involving clinical problem-solving. SUBJECTS AND METHODS: Students were taught "how, why, and so what" about CMs at the start of the course. Each student drew one CM every week and a minimum of ten throughout the course and submitted them for evaluation and corrections...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28627355/-recent-advances-in-the-pathogenesis-and-treatment-of-hypoproteinemia-after-surgical-stress
#9
Siyuan Jiang, Jin Zhang
After major operation, a series of complicated pathological and physiological changes will occur during the trauma and stress state. The protein synthesis is affected, which results in negative nitrogen balance. In addition, the release of inflammatory factors can damage the capillary endothelial cells and increase the permeability of micrangium, induce vascular colloidal albumin leakage to the extravascular tissue, decrease plasma albumin, make wound edema, eventually lead to postoperative hypoproteinemia...
March 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28625914/prioritizing-disease-causing-microbes-based-on-random-walking-on-the-heterogeneous-network
#10
Xianjun Shen, Yao Chen, Xingpeng Jiang, Xiaohua Hu, Tingting He, Jincai Yang
As we all know, the microbiota show remarkable variability within individuals. At the same time, those microorganisms living in the human body play a very important role in our health and disease, so the identification of the relationships between microbes and diseases will contribute to better understanding of microbes interactions, mechanism of functions. However, the microbial data which are obtained through the related technical sequencing is too much, but the known associations between the diseases and microbes are very less...
June 15, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28618848/the-stroke-caregiving-trajectory-in-relation-to-caregiver-depressive-symptoms-burden-and-intervention-outcomes
#11
Rachel Graf, Jennifer LeLaurin, Magda Schmitzberger, I Magaly Freytes, Tatiana Orozco, Stuti Dang, Constance R Uphold
BACKGROUND: Caregiver depression and burden have a detrimental effect on stroke survivors' rehabilitation and are contributors to stroke survivors' hospital readmission and institutionalization. The stroke caregiving trajectory is unique compared to other illnesses, and the effect of length of caregiving on stroke caregiver outcomes is poorly understood. Interventions can improve caregiver outcomes, but the optimal timing of these interventions is unclear. OBJECTIVES: We sought to determine the relationship between: (1) length of caregiving and stroke caregiver depressive symptoms and burden, and (2) length of caregiving and amount of change in depressive symptoms and burden following the Resources and Education for Stroke Caregivers' Understanding and Empowerment (RESCUE) intervention - an online and telephone problem-solving, education, and support intervention...
June 15, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28616875/stakeholders-qualitative-perspectives-of-effective-telepractice-pedagogy-in-speech-language-pathology
#12
Megan S Overby
BACKGROUND: Academic programmes in speech-language pathology are increasingly providing telehealth/telepractice clinical education to students. Despite this growth, there is little information describing effective ways to teach it. AIMS: The current exploratory study analyzed the perceptions of speech-language pathology/therapy (SLP/SLT) faculty, student and SLP/SLT clinicians to ascertain effective pedagogical approaches for telepractice service delivery, rank the relative importance of telepractice skills and knowledge competencies, and define any pedagogical challenges to teaching them...
June 14, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/28616401/recent-advancements-in-stent-therapy-in-patients-with-malignant-gastroduodenal-outlet-obstruction
#13
REVIEW
Hironari Kato, Koichiro Tsutsumi, Hiroyuki Okada
Gastric outlet obstruction (GOO) is one of severe comorbidities caused by many kinds of malignant diseases and is associated with not only degradation of patients' quality of life but also mortality. Although surgical bypass is one of the main therapies for malignant GOO, it is often difficult to perform in end-stage patients. The deployment of self-expandable metallic stents (SEMSs) has recently become a viable alternative to surgical bypass for malignant GOO. This technique is less invasive and more effective, particularly in patients with poor prognoses...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28614702/de-identification-of-psychiatric-intake-records-overview-of-2016-cegs-n-grid-shared-tasks-track-1
#14
Amber Stubbs, Michele Filannino, Özlem Uzuner
The 2016 CEGS N-GRID shared tasks for clinical records contained three tracks. Track 1 focused on de-identification of a new corpus of 1,000 psychiatric intake records. This track tackled de-identification in two sub-tracks: Track 1.A was a "sight unseen" task, where nine teams ran existing de-identification systems, without any modifications or training, on 600 new records in order to gauge how well systems generalize to new data. The best-performing system for this track scored an F1 of 0.799. Track 1.B was a traditional Natural Language Processing (NLP) shared task on de-identification, where 15 teams had two months to train their systems on the new data, then test it on an unannotated test set...
June 11, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28614554/efficacy-of-a-maternal-depression-prevention-strategy-in-head-start-a-randomized-clinical-trial
#15
Michael Silverstein, Yaminette Diaz-Linhart, Howard Cabral, William Beardslee, Mark Hegel, Winta Haile, Jenna Sander, Gregory Patts, Emily Feinberg
Importance: Low-income and minority mothers experience a disproportionate incidence of depression and lack access to treatment services. Development of prevention strategies in accessible community-based venues is a potentially important public health strategy. Objective: To determine the efficacy of a depression prevention strategy embedded in Head Start. Design, Setting, and Participants: This randomized clinical trial was performed from February 15, 2011, through May 9, 2016, at 6 Head Start agencies serving families at or below the federal poverty level...
June 14, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28608399/from-couple-therapy-1-0-to-a-comprehensive-model-a-roadmap-for-sequencing-and-integrating-systemic-psychodynamic-and-behavioral-approaches-in-couple-therapy
#16
Arthur C Nielsen
Couple therapy is a complex undertaking that proceeds best by integrating various schools of thought. Grounded in an in-depth review of the clinical and research literature, and drawing on the author's 40-plus years of experience, this paper presents a comprehensive, flexible, and user-friendly roadmap for conducting couple therapy. It begins by describing "Couple Therapy 1.0," the basic conjoint couple therapy format in which partners talk to each other with the help of the therapist. After noting the limitations of this model, the paper introduces upgrades derived from systemic, psychodynamic, and behavioral/educational approaches, and shows how to combine and sequence them...
June 13, 2017: Family Process
https://www.readbyqxmd.com/read/28607655/challenges-of-osce-national-board-exam-in-iran-from-participants-perspective
#17
Ali Emadzadeh, Yalda Ravanshad, Abass Makarem, Anoush Azarfar, Sahar Ravanshad, Shapour Badiee Aval, Hassan Mehrad-Majd, Anahita Alizadeh
BACKGROUND: The national board exam for residents in Iran is held in two parts: Multiple-choice and Objective Structured Clinical Examination (OSCE). The OSCE is a suitable method for evaluation of residents' clinical qualifications. However, it requires experienced human resources, accurate planning, facilities and reliable evaluation tools. OBJECTIVE: To determine the challenges of the OSCE National Board Exam in Iran. METHODS: This cross-sectional study was conducted on all the final-year pediatrics and gynecology residents of Mashhad University of Medical Science, who participated in the board exam in September 2014...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28606261/-investigation-of-reason-and-treatment-methods-for-active-refractory-and-recurrence-thyroid-associated-ophthalmopathy
#18
Q L Luo
TAO is a common autoimmune orbital disease. 20% to 30% patients in active phase of moderate to severe TAO have no reponse to treatment or relapse after treatment, which become a difficult problem in clinical treatment. In this paper, the necessity of the treatment, etiology, treatment difficulties and treatment measures of TAO are discussed, in order to make great efforts to solve the clinical problems and to treat such patients. (Chin J Ophthalmol, 2017, 53: 408-412).
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28603934/model-based-t1-mapping-with-sparsity-constraints-using-single-shot-inversion-recovery-radial-flash
#19
Xiaoqing Wang, Volkert Roeloffs, Jakob Klosowski, Zhengguo Tan, Dirk Voit, Martin Uecker, Jens Frahm
PURPOSE: To develop a model-based reconstruction technique for single-shot T1 mapping with high spatial resolution, accuracy, and precision using an inversion-recovery (IR) fast low-angle shot (FLASH) acquisition with radial encoding. METHODS: The proposed model-based reconstruction jointly estimates all model parameters, that is, the equilibrium magnetization, steady-state magnetization, 1/ T1*, and all coil sensitivities from the data of a single-shot IR FLASH acquisition with a small golden-angle radial trajectory...
June 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28603407/simultaneous-tumor-segmentation-image-restoration-and-blur-kernel-estimation-in-pet-using-multiple-regularizations
#20
Laquan Li, Jian Wang, Wei Lu, Shan Tan
Accurate tumor segmentation from PET images is crucial in many radiation oncology applications. Among others, partial volume effect (PVE) is recognized as one of the most important factors degrading imaging quality and segmentation accuracy in PET. Taking into account that image restoration and tumor segmentation are tightly coupled and can promote each other, we proposed a variational method to solve both problems simultaneously in this study. The proposed method integrated total variation (TV) semi-blind de-convolution and Mumford-Shah segmentation with multiple regularizations...
February 2017: Computer Vision and Image Understanding: CVIU
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