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https://www.readbyqxmd.com/read/28945017/-a-strategy-of-constructing-the-technological-system-for-quality-control-of-chinese-medicine-based-on-process-control-and-management
#1
Yi-Yu Cheng, Zhong-Zhi Qian, Bo-Li Zhang
The current situation, bottleneck problems and severe challenges in quality control technology of Chinese Medicine (CM) are briefly described. It is presented to change the phenomenon related to the post-test as the main means and contempt for process control in drug regulation, reverse the situation of neglecting the development of process control and management technology for pharmaceutical manufacture and reconstruct the technological system for quality control of CM products. The regulation and technology system based on process control and management for controlling CM quality should be established to solve weighty realistic problems of CM industry from the root causes, including backwardness of quality control technology, weakness of quality risk control measures, poor reputation of product quality and so on...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944347/fiber-orientation-estimation-guided-by-a-deep-network
#2
Chuyang Ye, Jerry L Prince
Diffusion magnetic resonance imaging (dMRI) is currently the only tool for noninvasively imaging the brain's white matter tracts. The fiber orientation (FO) is a key feature computed from dMRI for tract reconstruction. Because the number of FOs in a voxel is usually small, dictionary-based sparse reconstruction has been used to estimate FOs. However, accurate estimation of complex FO configurations in the presence of noise can still be challenging. In this work we explore the use of a deep network for FO estimation in a dictionary-based framework and propose an algorithm named Fiber Orientation Reconstruction guided by a Deep Network (FORDN)...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28943682/residual-weighted-learning-for-estimating-individualized-treatment-rules
#3
Xin Zhou, Nicole Mayer-Hamblett, Umer Khan, Michael R Kosorok
Personalized medicine has received increasing attention among statisticians, computer scientists, and clinical practitioners. A major component of personalized medicine is the estimation of individualized treatment rules (ITRs). Recently, Zhao et al. (2012) proposed outcome weighted learning (OWL) to construct ITRs that directly optimize the clinical outcome. Although OWL opens the door to introducing machine learning techniques to optimal treatment regimes, it still has some problems in performance. (1) The estimated ITR of OWL is affected by a simple shift of the outcome...
2017: Journal of the American Statistical Association
https://www.readbyqxmd.com/read/28942692/the-role-of-tele-medicine-in-patients-with-respiratory-diseases
#4
Nicolino Ambrosino, Claudio Fracchia
Tele-medicine is a clinical application connecting a patient with specialized care consultants by means of electronic platforms, potentially able to improve patients' self-management and allow for the care of patients with limited access to health services. This article summarizes the use of tele-medicine as a tool in managing patients suffering from some pathological respiratory conditions. Areas covered: We searched papers published between 1990 and 2017 dealing with tele-medicine and respiratory diseases, COPD, asthma, interstitial lung disease, chronic respiratory failure, neuromuscular diseases, critical illness, home mechanical ventilation, and also legal and economic issues...
September 25, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28942096/evaluation-of-students-knowledge-about-paediatric-dosage-calculations
#5
Nurcan Özyazıcıoğlu, Ayla İrem Aydın, Semra Sürenler, Hava Gökdere Çinar, Dilek Yılmaz, Burcu Arkan, Gülseren Çıtak Tunç
Medication errors are common and may jeopardize the patient safety. As paediatric dosages are calculated based on the child's age and weight, risk of error in dosage calculations is increasing. In paediatric patients, overdose drug prescribed regardless of the child's weight, age and clinical picture may lead to excessive toxicity and mortalities while low doses may delay the treatment. This study was carried out to evaluate the knowledge of nursing students about paediatric dosage calculations. This research, which is of retrospective type, covers a population consisting of all the 3rd grade students at the bachelor's degree in May, 2015 (148 students)...
September 19, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28941757/contrast-enhanced-spectral-mammography-as-work-up-tool-in-patients-recalled-from-breast-cancer-screening-has-low-risks-and-might-hold-clinical-benefits
#6
I P L Houben, P Van de Voorde, C R L P N Jeukens, J E Wildberger, L F Kooreman, M L Smidt, M B I Lobbes
OBJECTIVE: Contrast-enhanced spectral mammography (CESM) is a reliable problem solving tool in the work-up of women recalled from breast cancer screening. We evaluated additional findings caused by CESM alone and outweighed them against the disadvantages of this technique. METHODS: From December 2012 to December 2015, all women recalled from screening who underwent CESM were considered for this study. Radiation exposure and number of adverse contrast reactions were analysed...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28936445/principal-components-analysis-in-clinical-studies
#7
EDITORIAL
Zhongheng Zhang, Adela Castelló
In multivariate analysis, independent variables are usually correlated to each other which can introduce multicollinearity in the regression models. One approach to solve this problem is to apply principal components analysis (PCA) over these variables. This method uses orthogonal transformation to represent sets of potentially correlated variables with principal components (PC) that are linearly uncorrelated. PCs are ordered so that the first PC has the largest possible variance and only some components are selected to represent the correlated variables...
September 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28933614/coping-strategies-and-adjustment-to-multiple-sclerosis-among-recently-diagnosed-patients-the-mediating-role-of-sense-of-coherence
#8
Emanuela Calandri, Federica Graziano, Martina Borghi, Silvia Bonino
OBJECTIVE: To examine the relationship between coping strategies (problem solving, emotional release, and avoidance) and adjustment (health-related quality of life, depression, and affective well-being) in a group of recently diagnosed multiple sclerosis patients (up to three years since diagnosis), and to explore the mediating role of sense of coherence between coping strategies and adjustment. DESIGN: Cross-sectional. SETTING: Multiple Sclerosis Clinic Centre...
October 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28932227/targeted-delivery-of-neutralizing-anti-c5-antibody-to-renal-endothelium-prevents-complement-dependent-tissue-damage
#9
Paolo Durigutto, Daniele Sblattero, Stefania Biffi, Luca De Maso, Chiara Garrovo, Gabriele Baj, Federico Colombo, Fabio Fischetti, Antonio F Di Naro, Francesco Tedesco, Paolo Macor
Complement activation is largely implicated in the pathogenesis of several clinical conditions and its therapeutic neutralization has proven effective in preventing tissue and organ damage. A problem that still needs to be solved in the therapeutic control of complement-mediated diseases is how to avoid side effects associated with chronic neutralization of the complement system, in particular, the increased risk of infections. We addressed this issue developing a strategy based on the preferential delivery of a C5 complement inhibitor to the organ involved in the pathologic process...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28926293/the-development-of-a-novel-wound-healing-material-silk-elastin-sponge
#10
Shingo Kawabata, Katsuya Kawai, Satoshi Somamoto, Kazuo Noda, Yoshitaka Matsuura, Yoko Nakamura, Shigehiko Suzuki
Silk-elastin is a recombinant protein polymer with repeating units of silk and elastin blocks. This novel wound healing promoting material has the ability to self-assemble from a liquid to a gel. We have already reported that an aqueous solution of silk-elastin has the potential to accelerate wound healing; however, there are several problems in applying silk-elastin in the clinical setting. To solve these problems, we developed a silk-elastin sponge that is easy to use in the clinical setting. In the present study, we examined whether the wound healing effect of the silk-elastin sponge is equal to the aqueous solution of silk-elastin in vivo...
September 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28925287/assessing-and-developing-the-written-reflective-practice-skills-of-speech-language-pathology-students
#11
Kate Cook, Gina Tillard, Christine Wyles, Daniel Gerhard, Tika Ormond, Megan McAuliffe
PURPOSE: Written reflective practice aims to support critical thinking and problem solving skills in speech-language pathology (SLP) clinical education programmes. Yet, there has been limited investigation of students' development of written reflective practice skills over time and during a real-time clinical experience. The purpose of this study was to investigate students' development of breadth and depth of written reflective practice across a six-week clinical experience. METHOD: Participants were 59 undergraduate and 14 postgraduate SLP students...
September 19, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28921660/rapid-whole-brain-gray-matter-imaging-using-single-slab-three-dimensional-dual-echo-fast-spin-echo-a-feasibility-study
#12
Hyunyeol Lee, Eung Yeop Kim, Chul-Ho Sohn, Jaeseok Park
PURPOSE: To achieve rapid, high resolution whole-brain gray matter (GM) imaging by developing a novel, single-slab three-dimensional dual-echo fast-spin-echo pulse sequence and GM-selective reconstruction. METHODS: Unlike conventional GM imaging that uses time-consuming double-inversion-recovery preparation, the proposed pulse sequence was designed to have two split portions along the echo train, in which the first half was dedicated to yield short inversion recovery (IR)-induced white matter suppression and variable-flip-angle-induced two-step GM signal evolution while the second half cerebrospinal fluid-only signals...
September 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28921043/slow-wave-activity-and-executive-dysfunction-in-children-with-sleep-disordered-breathing
#13
Jessica A Christiansz, Chloe R Lappin, Aidan J Weichard, Gillian M Nixon, Margot J Davey, Rosemary S C Horne, Sarah N Biggs
PURPOSE: This study aimed to examine slow wave activity (SWA), a marker of homeostatic regulation, as a potential mechanism linking sleep disordered breathing (SDB) with executive dysfunction in children. METHODS: Executive function domains of working memory, spatial planning, information processing, and sustained attention were assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB) in children (N = 40; 5-12 years) referred for clinical diagnosis of SDB...
September 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28915872/risk-factors-of-chronic-periodontitis-on-healing-response-a-multilevel-modelling-analysis
#14
J Song, H Zhao, C Pan, C Li, J Liu, Y Pan
BACKGROUND: Chronic periodontitis is a multifactorial polygenetic disease with an increasing number of associated factors that have been identified over recent decades. Longitudinal epidemiologic studies have demonstrated that the risk factors were related to the progression of the disease. A traditional multivariate regression model was used to find risk factors associated with chronic periodontitis. However, the approach requirement of standard statistical procedures demands individual independence...
September 15, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28906232/the-pharmaceutical-industry-and-the-canadian-government-folie-%C3%A3-deux
#15
Joel Lexchin
The interest of the pharmaceutical industry is in achieving a profit for its shareholders while the interest of the Canadian government should be in protecting public health. However, over the course of the past few decades the actions of the Canadian government have been tilted in favour of industry in two areas. The first is in the relationship between industry and Health Canada and is manifested in the regulation of clinical trials, the drug approval system, drug safety and promotion. The second is in economic policy as it applies to policies about patent protection, the price of medications and measures taken to incentivize research and development...
August 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28903566/biobanking-the-first-step-to-successful-liquid-biopsy-experiments
#16
M Almasi, S Sevcikova, M Penka, M Krejci, Z Adam, P Vrublova, T Jelínek, R Hájek
BACKGROUND: Archiving of biological materials in biobanks is considered to be the initial crucial part of research activities. Most often, biobanks are founded for research purposes since they allow collection of sufficient material for analysis of new or testing of previously identified biomarkers. Biobanking needs to quickly react to current needs of researchers as well as clinicians, it is not a rigid system. Laboratory analyses of monoclonal gammopathies are based on separation of plasma cells from bone marrow of patients...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28902237/bonding-efficiency-and-durability-current-possibilities
#17
Adriana Bona Matos, Livia Tosi Trevelin, Beatriz Togoro Ferreira da Silva, Luciana Fávaro Francisconi-Dos-Rios, Luciana Kfouri Siriani, Marcio Vivan Cardoso
Bonding plays a major role in dentistry nowadays. Dental adhesives are used in association with composites to solve many restorative issues. However, the wide variety of bonding agents currently available makes it difficult for clinicians to choose the best alternative in terms of material and technique, especially when different clinical situations are considered. Moreover, although bonding agents allow for a more conservative restorative approach, achieving a durable adhesive interface remains a matter of concern, and this mainly due to degradation of the bonding complex in the challenging oral environment...
August 28, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28901829/resilience-to-discrimination-and-rejection-among-young-sexual-minority-males-and-transgender-females-a-qualitative-study-on-coping-with-minority-stress
#18
Laura Jane Bry, Brian Mustanski, Robert Garofalo, Michelle Nicole Burns
Sexual minority and transgender status is associated with mental health disparities, which have been empirically and theoretically linked to stressors related to social stigma. Despite exposure to these unique stressors, many sexual minority and transgender individuals will not experience mental health disorders in their lifetime. Little is known about the specific processes that sexual minority and transgender youth use to maintain their wellbeing in the presence of discrimination and rejection. Semi-structured interviews were conducted with 10 sexual minority males and transgender females aged 18-22 years, who currently met criteria for an operationalized definition of resilience to depression and anxiety...
September 13, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28900666/-psychotherapeutic-approaches-for-treatment-of-the-elderly
#19
REVIEW
M Hautzinger, P Dykierek, A Fellgiebel, M Hüll
BACKGROUND: This article focusses on the possibilities, varieties, indications, and benefits of psychotherapy with elderly patients. OBJECTIVE: Which basic principles can be differentiated, what theoretical rationales are helpful for psychotherapy with the elderly and what kind and forms of psychotherapy are available? MATERIAL AND METHODS: Based on relevant references and research, clinically relevant and evidence-based psychotherapies are described, to understand the theoretical rationale, the goals, the procedure and main strategies...
September 12, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28898193/molecular-breast-imaging-in-breast-cancer-screening-and-problem-solving
#20
Robin B Shermis, Roberta E Redfern, Jessica Burns, Haris Kudrolli
In the United States, legislative actions in over 28 states require radiologists to notify women who undergo breast screening mammography of their breast density. This has led to increased public interest in supplemental screening, but radiologists have not come to a consensus on a supplemental screening modality. In choosing between the most common options, whole-breast ultrasonography (US) and magnetic resonance (MR) imaging, one must weigh the benefits and drawbacks of each modality, as increased cancer detection may be accompanied by increased examination costs and biopsy rates...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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