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https://www.readbyqxmd.com/read/29145451/stromal-interaction-molecule-1-haploinsufficiency-causes-maladaptive-response-to-pressure-overload
#1
Takayoshi Ohba, Hiroyuki Watanabe, Manabu Murakami, Kenji Iino, Takeshi Adachi, Yoshihiro Baba, Tomohiro Kurosaki, Kyoichi Ono, Hiroshi Ito
Stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca2+ sensor, has been shown to control a Ca2+-dependent signal that promotes cardiac hypertrophy. However, whether STIM1 has adaptive role that helps to protect against cardiac overload stress remains unknown. We hypothesized that STIM1 deficiency causes a maladaptive response to pressure overload stress. We investigated STIM1 heterozygous KO (STIM1+/-) mice hearts, in which STIM1 protein levels decreased to 27% of wild-type (WT) with no compensatory increase in STIM2...
2017: PloS One
https://www.readbyqxmd.com/read/29135229/effects-of-nh4-k-mg-2-and-ca-2-on-the-cesium-adsorption-desorption-in-binding-sites-of-vermiculitized-biotite
#2
Xiangbiao Yin, Xinpeng Wang, Hao Wu, Hideharu Takahashi, Yusuke Inaba, Toshihiko Ohnuki, Kenji Takeshita
The reversibility of cesium adsorption in contaminated soil is largely dependent on its interaction with micaceous minerals, which may be greatly influenced by various cations. Herein, we systematically investigated the effects of NH4(+), K(+), Mg(2+), and Ca(2+) on the adsorption/desorption of Cs(+) into different binding sites of vermiculitized biotite (VB). Original VB was initially saturated by NH4(+), K(+), or Mg(2+); we then evaluated the adsorption of Cs(+) on three treated VBs, and the desorption by extraction with NH4(+), K(+), Mg(2+), or Ca(2+) was further evaluated...
November 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29133370/a-mucin-like-protein-of-planthopper-is-required-for-feeding-and-induces-immunity-response-in-plants
#3
Xinxin Shangguan, Jing Zhang, Bingfang Liu, Yan Zhao, Huiying Wang, Zhizheng Wang, Jianping Guo, Weiwei Rao, Shengli Jing, Wei Guan, Yinhua Ma, Yan Wu, Liang Hu, Rongzhi Chen, Bo Du, Lili Zhu, Dazhao Yu, Guangcun He
The brown planthopper, Nilaparvata lugens (Stål), is a pest that threatens rice production worldwide. While feeding on rice plants, planthoppers secrete saliva, which plays crucial roles in nutrient ingestion and modulating plant defense responses, although the specific functions of salivary proteins remain largely unknown. We identified a N. lugens-secreted mucin-like protein (NlMLP) by transcriptome and proteome analyses and characterized its function, both in brown planthopper and in plants. NlMLP is highly expressed in salivary glands and is secreted into rice during feeding...
November 13, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29132211/aggregation-behavior-of-dissolved-black-carbon-implications-for-vertical-mass-flux-and-fractionation-in-aquatic-systems
#4
Fanchao Xu, Chenhui Wei, Qingqing Zeng, Xuening Li, Pedro J J Alvarez, Qilin Li, Xiaolei Qu, Dongqiang Zhu
The fluvial export of dissolved black carbon (DBC) is a major land-ocean flux in the global black carbon cycle, affecting the size of refractory carbon pool in the oceans. The aggregation behavior of DBC is a significant determinant of its transport and vertical mass flux. In this study, the aggregation kinetics and interaction energy of DBC leached from biochar were investigated. DBC was mainly stabilized by hydration force and underwent structural compacting in divalent cation solutions. Na+ and Mg2+ had limited impact on the colloidal stability of DBC due to the strong hydration of these cations...
November 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29122954/pregnancy-adapted-uterine-artery-endothelial-cell-ca2-signaling-and-its-relationship-with-membrane-potential
#5
Roxanne E Alvarez, Derek S Boeldt, Bikash R Pattnaik, Hannah L Friedman, Ian M Bird
Pregnancy-derived uterine artery endothelial cells (P-UAEC) express P2Y2 receptors and at high cell density show sustained and synchronous [Ca2+]i burst responses in response to ATP Bursts in turn require coupling of transient receptor potential canonical type3 channel (TRPC3) and inositol 1,4,5-triphosphate receptor type 2 (IP3R2), which is upregulated in P-UAEC in a manner dependent on connexin 43 (Cx43) gap junctions. While there is no known direct interaction of TRPC3 with Cx43, early descriptions of TRPC3 function showed it may also be influenced by altered membrane potential (Vm)...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29112819/humidity-and-sunlight-driven-motion-of-a-chemically-bonded-polymer-bilayer-with-programmable-surface-patterns
#6
Lidong Zhang, Xiaxin Qiu, Yihui Yuan, Ting Zhang
We report a bilayer of sodium alginate/polyvinylidene fluoride (SA/PVDF) that is chemically bonded through a series of interfacial coupling reactions. The SA layer is hydrophilic in structure and is capable of strong interaction with water molecules, thus presenting high sensitivity to humidity, whereas the PVDF layer is hydrophobic, inert to humidity. This structural feature results in the bilayer having asymmetric humidity-responsive performances that can thus make its shape change with directionality, which cannot be achieved in an SA single layer...
November 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29107707/time-of-day-but-not-aging-regulates-5-ht7-receptor-binding-sites-in-the-hamster-hippocampus
#7
Marilyn J Duncan, J Tyler Smith, Kathleen M Franklin
Activation of 5-HT7 receptors influences memory as well as circadian rhythms and other processes. This study investigated the regulation of the 5-HT7 receptors in the hippocampus, a likely substrate for the effects of 5-HT7 receptor compounds on memory. Because endogenous serotonin release is higher during the active phase, and chronic treatment with a serotonin-selective reuptake inhibitor down-regulates 5-HT7 receptors, we hypothesized that 5-HT7 receptors exhibit 24-h variations. We also hypothesized that aging decreases 5-HT7 receptors in the hippocampus, as it does in the dorsal raphe nucleus, a brain site for serotonergic resetting of circadian rhythms...
October 28, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29081402/conformational-memory-in-the-association-of-the-transmembrane-protein-phospholamban-with-the-sarcoplasmic-reticulum-calcium-pump-serca
#8
Serena Smeazzetto, Gareth P Armanious, Marai Rosa Moncelli, Jessi J Bak, M Joanne Lemieux, Howard S Young, Francesco Tadini-Buoninsegni
The sarcoplasmic reticulum Ca2+-ATPase SERCA promotes muscle relaxation by pumping calcium ions from the cytoplasm into the sarcoplasmic reticulum. SERCA activity is regulated by a variety of small transmembrane peptides, most notably by phospholamban in cardiac muscle and sarcolipin in skeletal muscle. However, how phospholamban and sarcolipin regulate SERCA is not fully understood. In the present study, we evaluated the effects of phospholamban and sarcolipin on calcium translocation and ATP hydrolysis by SERCA under conditions that mimic environments in sarcoplasmic reticulum membranes...
October 29, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29077388/adsorption-behaviors-of-organic-micropollutants-on-zirconium-metal-organic-framework-uio-66-analysis-of-surface-interactions
#9
Caiqin Chen, Dezhi Chen, Shasha Xie, Hongying Quan, Xubiao Luo, Lin Guo
Herein, we studied the adsorption behaviors of organic micropollutants, such as anticonvulsant carbamazepine (CBZ) and antibiotic tetracycline hydrochloride (TC), on zirconium metal-organic framework UiO-66 in water. The maximum adsorption capacities of CBZ and TC on the UiO-66 were 37.2 and 23.1 mg·g(-1) at 25 °C, respectively. The adsorption isotherms and kinetics of CBZ and TC were well described by using the Langmuir model and pseudo-second-order model, respectively, and the adsorptions on UiO-66 are endothermic reactions...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29076615/ultrasensitive-dnazyme-based-ca-2-detection-boosted-by-ethanol-and-a-solvent-compatible-scaffold-for-aptazyme-design
#10
Tianmeng Yu, Wenhu Zhou, Juewen Liu
Functional DNA includes aptamers and DNAzymes, and metal ions are often important for achieving the chemical functions of such DNA. Biosensors based on functional DNA have mainly been tested in aqueous buffers. By introducing organic solvents with much lower dielectric constants, the interaction between metal ions and DNA can be significantly enhanced, and this might affect the performance of DNA-based biosensors. In this work, the effect of ethanol on the activity of the EtNa DNAzyme was studied for Ca(2+) detection...
October 27, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29072343/low-cost-and-scaled-up-production-of-fluorine-free-substrate-independent-large-area-superhydrophobic-coatings-based-on-hydroxyapatite-nanowires-bundles
#11
Fei-Fei Chen, Zi-Yue Yang, Ying-Jie Zhu, Zhi-Chao Xiong, Li-Ying Dong, Bing-Qiang Lu, Jin Wu, Ri-Long Yang
Up to date, the scaled-up production and large-area applications of the superhydrophobic coatings are limited because the complicated procedures, environmentally harmful fluorinated compounds, restrictive substrates, expensive equipments and raw materials are usually involved in the fabrication process. Herein, we report the facile, low-cost and green production of the superhydrophobic coatings based on hydroxyapatite nanowire bundles (HNBs). Hydrophobic HNBs are synthesized by one-step solvothermal method using oleic acid as the structure-directing and hydrophobic agent...
October 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29046349/differential-regulation-of-the-rac1-gtpase-activating-protein-gap-bcr-during-oxygen-glucose-deprivation-in-hippocampal-and-cortical-neurons
#12
Katharine R Smith, Dipen Rajgor, Jonathan G Hanley
Brain ischemia causes oxygen and glucose deprivation (OGD) in neurons, triggering a cascade of events leading to synaptic accumulation of glutamate. Excessive activation of glutamate receptors causes excitotoxicity and delayed cell death in vulnerable neurons. Following global cerebral ischemia, hippocampal CA1 pyramidal neurons are more vulnerable to injury than their cortical counterparts, but the mechanisms that underlie this difference are unclear. Signalling via Rho-family small GTPases, their upstream Guanine nucleotide Exchange Factors (GEFs) and GTPase Activating Proteins (GAPs) is differentially dysregulated in response to OGD/ischemia in hippocampal and cortical neurons...
October 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29045780/mechanisms-of-activation-and-subunit-release-in-ca-2-calmodulin-dependent-protein-kinase-ii
#13
Filippo Pullara, Eliana K Asciutto, Ignacio J General
Calcium/calmodulin-dependent protein kinase II is an enzyme involved in many different functions, including the so-called long-term potentiation, a mechanism that strengthens synapses in a persistent mode and is believed to be a basic cellular mechanism for memory formation. Here we study the conformational changes of the enzyme due to phosphorylation of some key residues that are believed to drive the transition from an inhibited to an active state; it is this active state the one associated with long-term potentiation...
November 1, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29045717/interaction-between-calcium-and-potassium-modulates-elongation-rate-in-cotton-fiber-cells
#14
Kai Guo, Lili Tu, Yonghui He, Jinwu Deng, Maojun Wang, Hui Huang, Zhonghua Li, Xianlong Zhang
Calcium (Ca2+) is necessary for fiber cell development in cotton (Gossypium hirsutum), both as a cell wall structural component and for environmental signaling responses. It is also known that potassium (K+) plays a critical role in cotton fiber cell elongation. However, it is unclear whether Ca2+ integrates its activities with K+ to regulate fiber elongation. Here, we report the novel discovery that Ca2+ deficiency, when integrated with K+ signaling, promotes fiber elongation. Using inductively coupled plasma-mass spectrometry (ICP-MS), we determined dynamic profiles of the ionome in ovules and fibers at different developmental stages, and found that a high accumulation of macro-elements, but not Ca2+, was associated with longer fibers...
October 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29045568/loss-of-protein-kinase-novel-1-pkn1-is-associated-with-mild-systolic-and-diastolic-contractile-dysfunction-increased-phospholamban-thr17-phosphorylation-and-exacerbated-ischaemia-reperfusion-injury
#15
Asvi A Francois, Kofo Obasanjo-Blackshire, James E Clark, Andrii Boguslavskyi, Mark R Holt, Peter Parker, Michael S Marber, Richard J Heads
Aims: PKN1 is a stress-responsive protein kinase acting downstream of small GTP-binding proteins of the Rho/Rac family. The aim was to determine its role in endogenous cardioprotection. Methods and Results: Hearts from PKN1 knockout (KO) or wild type (WT) littermate control mice were perfused in Langendorff mode and subjected to global ischemia and reperfusion (I/R). Myocardial infarct size was doubled in PKN1 KO hearts compared to WT hearts. PKN1 was basally phosphorylated on the activation loop Thr778 PDK1 target site which was unchanged during I/R...
October 16, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29028796/bak1-is-involved-in-atralf1-induced-inhibition-of-root-cell-expansion
#16
Keini Dressano, Paulo H O Ceciliato, Aparecida L Silva, Juan Carlos Guerrero-Abad, Tábata Bergonci, Fausto Andrés Ortiz-Morea, Marco Bürger, Marcio C Silva-Filho, Daniel S Moura
The rapid alkalinization factor (RALF) peptide negatively regulates cell expansion, and an antagonistic relationship has been demonstrated between AtRALF1, a root-specific RALF isoform in Arabidopsis, and brassinosteroids (BRs). An evaluation of the response of BR signaling mutants to AtRALF1 revealed that BRI1-associated receptor kinase1 (bak1) mutants are insensitive to AtRALF1 root growth inhibition activity. BAK1 was essential for the induction of AtRALF1-responsive genes but showed no effect on the mobilization of Ca2+ and alkalinization responses...
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28987883/galnac-bio-functionalization-of-nanoparticles-assembled-by-electrostatic-interactions-improves-sirna-targeting-to-the-liver
#17
Efrat Korin, Tzlil Bejerano, Smadar Cohen
RNA interference (RNAi) has the potential to reversibly silence any gene with high efficiency and specificity. To fulfill the clinical potential of RNAi, delivery vehicles are required to transport the short interfering RNA (siRNA) to the site of action in the cells of target tissues. Here, we describe the features of novel liver-targeted siRNA nanoparticles (NPs), co-assembled due to the complexation of alginate sulfate (AlgS) with siRNA, mediated by calcium ions bridges (AlgS-Ca(2+)-siRNA NPs) and then bioconjugation of a targeting ligand onto the AlgS upon the NP surface...
October 4, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28981598/mixed-lineage-kinase-domain-like-protein-induces-rgc-5-necroptosis-following-elevated-hydrostatic-pressure
#18
Lvshuang Liao, Lei Shang, Na Li, Shuchao Wang, Mi Wang, Yanxia Huang, Dan Chen, Jufang Huang, Kun Xiong
Receptor-interacting protein 3 (RIP3) is an essential component of the necroptosis signaling pathway. Phosphorylation of its downstream target, mixed lineage kinase domain-like protein (MLKL), has been proposed to induce necroptosis by initiating Ca2+ influx. Our previous studies have shown that RGC-5 retinal ganglion cells undergo RIP3-mediated necroptosis following elevated hydrostatic pressure (EHP). However, the molecular mechanism underlying necroptosis induction downstream of RIP3 is still not well understood...
October 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28973908/substance-p-induces-plasticity-and-synaptic-tagging-capture-in-rat-hippocampal-area-ca2
#19
Ananya Dasgupta, Nimmi Baby, Kumar Krishna, Muhammad Hakim, Yuk Peng Wong, Thomas Behnisch, Tuck Wah Soong, Sreedharan Sajikumar
The hippocampal area Cornu Ammonis (CA) CA2 is important for social interaction and is innervated by Substance P (SP)-expressing supramammillary (SuM) nucleus neurons. SP exerts neuromodulatory effects on pain processing and central synaptic transmission. Here we provide evidence that SP can induce a slowly developing NMDA receptor- and protein synthesis-dependent potentiation of synaptic transmission that can be induced not only at entorhinal cortical (EC)-CA2 synapses but also at long-term potentiation (LTP)-resistant Schaffer collateral (SC)-CA2 synapses...
October 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28973175/amyotrophic-lateral-sclerosis-associated-mutant-sod1-inhibits-anterograde-axonal-transport-of-mitochondria-by-reducing-miro1-levels
#20
Annekathrin Moller, Claudia S Bauer, Rebecca N Cohen, Christopher P Webster, Kurt J De Vos
Defective axonal transport is an early neuropathological feature of amyotrophic lateral sclerosis (ALS). We have previously shown that ALS-associated mutations in Cu/Zn superoxide dismutase 1 (SOD1) impair axonal transport of mitochondria in motor neurons isolated from SOD1 G93A transgenic mice and in ALS mutant SOD1 transfected cortical neurons, but the underlying mechanisms remained unresolved.The outer mitochondrial membrane protein mitochondrial Rho GTPase 1 (Miro1) is a master regulator of mitochondrial axonal transport in response to cytosolic calcium (Ca2+) levels ([Ca2+]c) and mitochondrial damage...
September 14, 2017: Human Molecular Genetics
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