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opiate use disorder

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https://www.readbyqxmd.com/read/28631421/impact-of-synthetic-cannabinoids-on-the-duration-of-opioid-related-withdrawal-and-craving-among-patients-of-addiction-clinics-in-kazakhstan-a-prospective-case-control-study
#1
Mariya Prilutskaya, Francesco Saverio Bersani, Ornella Corazza, Sergey Molchanov
OBJECTIVE: The aim of the study was to prospectively assess whether regular use of synthetic cannabinoids (SCs) affects the duration of opioid-related withdrawal and craving symptoms in patients undergoing drug detoxification treatments. METHODS: Patients (n = 193) with opioid use disorder, among which 47 patients are regularly using SCs, underwent integrated drug detoxification therapies. The Clinical Opiate Withdrawal Scale and a specific visual analogue scale were used to assess opioid withdrawal and craving symptoms over time...
June 20, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28630256/the-small-gtpase-rac1-contributes-to-extinction-of-aversive-memories-of-drug-withdrawal-by-facilitating-gabaa-receptor-endocytosis-in-the-vmpfc
#2
Wei-Sheng Wang, Yun-Yue Ju, Qi-Xin Zhou, Jian-Xin Tang, Meng Li, Lei Zhang, Shuo Kang, Zhong-Guo Chen, Yu-Jun Wang, Hui Ji, Yu-Qiang Ding, Lin Xu, Jing-Gen Liu
Extinction of aversive memories has been a major concern in neuropsychiatric disorders such as anxiety disorders and drug addiction. However, the mechanisms underlying extinction of aversive memories are not fully understood. Here, we report that extinction of conditioned place aversion (CPA) to naloxone-precipitated opiate withdrawal in male rats activates Rho GTPase Rac1 in the ventromedial prefrontal cortex (vmPFC) in a BDNF-dependent manner, which determines GABAA receptor (GABAAR) endocytosis via triggering synaptic translocation of activity-regulated cytoskeleton-associated protein (Arc) through facilitating actin polymerization...
June 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28598698/beyond-serotonin-newer-antidepressants-in-the-future
#3
Gopalkumar Rakesh, Chi-Un Pae, Prakash S Masand
There are numerous antidepressants for the treatment of major depressive disorder (MDD) on the market. However, inadequate treatment response, therapeutic lag between drug administration and the onset of clinical improvement, and safety/tolerability issues with the use of contemporary antidepressants have accelerated the search for newer antidepressants with novel mechanisms of action. Areas covered: The authors review novel antidepressants with rapid efficacy for diverse MDD symptoms and have fewer adverse effects (AEs)...
June 19, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28581025/clinical-characteristics-and-treatment-patterns-among-patients-diagnosed-with-cluster-headache-in-u-s-healthcare-claims-data
#4
Casey K Choong, Janet H Ford, Allen W Nyhuis, Shivang G Joshi, Rebecca L Robinson, Sheena K Aurora, James M Martinez
OBJECTIVE: To characterize demographics, clinical characteristics, and treatment patterns of patients with cluster headache (CH). BACKGROUND: CH is an uncommon trigeminal autonomic cephalalgia with limited evidence-based treatment options. Patients suffer from extremely painful unilateral headache attacks and autonomic symptoms with episodic and chronic cycles. DESIGN/METHODS: This retrospective analysis used insurance claims from Truven Health Analytics MarketScan(®) research databases from 2009 to 2014...
June 5, 2017: Headache
https://www.readbyqxmd.com/read/28554599/pharmacokinetics-and-pharmacodynamics-of-a-buprenorphine-subcutaneous-depot-formulation-cam2038-for-once-weekly-dosing-in-patients-with-opioid-use-disorder
#5
Christian Haasen, Margareta Linden, Fredrik Tiberg
INTRODUCTION: Sublingual buprenorphine is effective for opioid dependence treatment but associated with misuse, abuse, and diversion. The present Phase I/II study evaluated a novel buprenorphine subcutaneous depot formulation for once-weekly dosing (CAM2038 q1w) in patients receiving maintenance treatment for opioid use disorder with daily sublingual buprenorphine. METHODS: After discontinuation of buprenorphine for 48h, patients received a single CAM2038 q1w dose based on their pre-study daily sublingual maintenance dose...
July 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28552055/promising-treatments-for-obsessive-compulsive-disorder-a-call-for-additional-research
#6
Lorrin M Koran, Elias Aboujaoude
Many patients with OCD respond partially or not at all to standard medications and cognitive behavioral therapy approaches, making alternate treatments necessary. We review the preliminary evidence that exists in support of the use of stimulants, high-dose caffeine, opiates, memantine, ondansetron, ketamine, and transcranial magnetic stimulation in some patients with OCD. Although limited by small or modest sample sizes, open-label study designs, and brief follow-up periods, studies suggest that each of these strategies can help some patients who have inadequately responded to first-line treatments...
May 26, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28550519/drug-abuse-associated-mortality-across-the-lifespan-a-population-based-longitudinal-cohort-and-co-relative-analysis
#7
Kenneth S Kendler, Henrik Ohlsson, Kristina Sundquist, Jan Sundquist
PURPOSE: Nationwide data have been lacking on drug abuse (DA)-associated mortality. We do not know the degree to which this excess mortality results from the characteristics of drug-abusing individuals or from the effects of DA itself. METHOD: DA was assessed from medical, criminal, and prescribed drug registries. Relative pairs discordant for DA were obtained from the Multi-Generation and Twin Registers. Mortality was obtained from the Swedish Mortality registry...
May 26, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28542470/differential-physiological-changes-following-internet-exposure-in-higher-and-lower-problematic-internet-users
#8
Phil Reed, Michela Romano, Federica Re, Alessandra Roaro, Lisa A Osborne, Caterina Viganò, Roberto Truzoli
Problematic internet use (PIU) has been suggested as in need of further research with a view to being included as a disorder in future Diagnostic and Statistical Manual (DSM) of the American Psychiatric Association, but lack of knowledge about the impact of internet cessation on physiological function remains a major gap in knowledge and a barrier to PIU classification. One hundred and forty-four participants were assessed for physiological (blood pressure and heart rate) and psychological (mood and state anxiety) function before and after an internet session...
2017: PloS One
https://www.readbyqxmd.com/read/28535456/effectiveness-of-treatment-for-opioid-use-disorder-a-national-five-year-prospective-observational-study-in-england
#9
Brian Eastwood, John Strang, John Marsden
BACKGROUND: This the first 5-year effectiveness study of publicly funded treatment for opioid use disorder (OUD) in England. METHODS: All adults initiating treatment in 2008/09 in all 149 local treatment systems reporting to the National Drug Treatment Monitoring System (n=54,347). Admission polydrug use sub-populations were identified by Latent Class Analysis. The treatment outcome measure was 'successful completion and no re-presentation within six months' (SCNR) analysed by multilevel, multivariable logistic regression and funnel plots to contrast outcome by treatment system...
May 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28511097/the-relationship-between-social-desirability-bias-and-self-reports-of-health-substance-use-and-social-network-factors-among-urban-substance-users-in-baltimore-maryland
#10
Carl A Latkin, Catie Edwards, Melissa A Davey-Rothwell, Karin E Tobin
BACKGROUND: Social desirability response bias may lead to inaccurate self-reports and erroneous study conclusions. The present study examined the relationship between social desirability response bias and self-reports of mental health, substance use, and social network factors among a community sample of inner-city substance users. METHODS: The study was conducted in a sample of 591 opiate and cocaine users in Baltimore, Maryland from 2009 to 2013. Modified items from the Marlowe-Crowne Social Desirability Scale were included in the survey, which was conducted face-to-face and using Audio Computer Self Administering Interview (ACASI) methods...
May 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28509838/long-term-effect-of-a-stigma-reduction-educational-intervention-for-physician-assistants
#11
Kathleen Crapanzano, Richard J Vath
PURPOSE: Stigma towards people with substance use disorders is a common phenomenon with far reaching effects. This study evaluated the long-term effect of using an educational intervention on the attitudes of physician assistant students. METHODS: Physician assistant students received a one-week educational intervention focused on substance abuse. Changes in student attitudes were measured one year later using the Attitude to Mental Health Questionnaire (AMIQ). RESULTS: Significant and sustained improvement was noted in attitudes in the AMIQ score for the opiate use disorder vignette; no significant change was noted in the alcohol use disorder vignette...
June 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28494249/evaluation-of-problematic-psychoactive-substances-use-in-people-placed-in-police-custody
#12
Marie Gérardin, Gabriel Guigand, Laura Wainstein, Pascale Jolliet, Caroline Victorri-Vigneau, Renaud Clément
INTRODUCTION AND AIMS: In France, the law states that any person held in custody could be examined by a doctor. The main objective of the medical examination is to give medical evidence of health compatibility with custody. This review identifies health risks such as addictive behaviour. We wanted to know which psychoactive substances are used in this particular population, and how problematic these uses are. DESIGN AND METHODS: A prospective, monocentric, open-ended study conducted via a structured questionnaire was carried out on detainees who reported having taken drugs or illegal substances...
July 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28479900/opiate-withdrawal-syndrome-in-buprenorphine-abusers-admitted-to-a-rehabilitation-center-in-tunisia
#13
Ines Derbel, Asma Ghorbel, Férièle Messadi Akrout, Abdelmajid Zahaf
BACKGROUND: Illicit use of high dosage buprenorphine has been well documented in several countries, including Tunisia. OBJECTIVES: The aim of this survey is to assess the buprenorphine withdrawal syndrome time course, and how it may be affected by the population characteristics among subjects admitted to a rehabilitation center in Tunisia. METHODS: A prospective research has permitted study of the socio-demographic characteristics and assessment of buprenorphine withdrawal syndrome among 32 subjects admitted for buprenorphine dependence by using the clinical opiate withdrawal scale...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28464965/risk-of-transition-to-schizophrenia-following-first-admission-with-substance-induced-psychotic-disorder-a-population-based-longitudinal-cohort-study
#14
H L Alderson, D M Semple, C Blayney, F Queirazza, V Chekuri, S M Lawrie
BACKGROUND: The potential for drugs of abuse to induce acute psychotic symptoms is well recognised. However, the likelihood of transition from initial substance-induced psychotic disorder (SIPD) to chronic psychosis is much less well understood. This study investigated the rate of SIPD transition to schizophrenia (F20), the time to conversion and other possible related factors. METHODS: Using data from the Scottish Morbidity Record, we examined all patients (n = 3486) since their first admission to psychiatric hospital with a diagnosis of SIPD [International Classification of Diseases, Tenth Revision (ICD-10) codes F10-F19, with third digit five] from January 1997 to July 2012...
May 3, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28461172/upregulation-of-iras-nischarin-i1-imidazoline-receptor-a-regulatory-protein-of-%C3%AE-opioid-receptor-trafficking-in-postmortem-prefrontal-cortex-of-long-term-opiate-and-mixed-opiate-cocaine-abusers
#15
Benjamin Keller, Romano La Harpe, Jesús A García-Sevilla
Imidazoline receptor antisera-selected (IRAS)/nischarin, a putative I1-imidazoline receptor, has recently been shown to regulate μ-opioid receptor (OR) trafficking and resensitisation. To study a possible involvement of this μ-OR regulator in opiate dependence, the present study assessed by Western blot analysis the contents of IRAS/nischarin and μ-OR in total homogenates and subcellular preparations of postmortem human prefrontal cortex (PFC/BA9) of long-term opiate and mixed opiate/cocaine abusers as well as of matched healthy control subjects...
April 28, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28429200/achalasia-it-is-not-all-black-and-white
#16
REVIEW
Santosh Sanagapalli, Rami Sweis
PURPOSE OF REVIEW: This review aims to shed light on subtleties of achalasia diagnosis, including potential pitfalls that may lead to errors. Optimal methods for assessment of disease severity and the relationship between achalasia and other motility disorders will also be reviewed with an emphasis on recent findings from the literature. RECENT FINDINGS: Adjunctive testing with viscous substances or larger water volumes should be used routinely as it improves the accuracy of achalasia diagnosis...
June 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28428748/resting-state-neuroimaging-and-neuropsychological-findings-in-opioid-use-disorder-during-abstinence-a-review
#17
REVIEW
Hada Fong-Ha Ieong, Zhen Yuan
Dependence to opiates, including illicit heroin and prescription pain killers, and treatment of the opioid use disorder (OUD) have been longstanding problems over the world. Despite intense efforts to scientific investigation and public health care, treatment outcomes have not significantly improved for the past 50 years. One reason behind the continuing use of heroin worldwide despite such efforts is its highly addictive nature. Brain imaging studies over the past two decades have made significant contribution to the understanding of the addictive properties as to be due in part to biological processes, specifically those in the brain structure and function...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28412916/cannabis-epidemiological-neurobiological-and-psychopathological-issues-an-update
#18
Maria Antonietta De Luca, Gaetano Di Chiara, Cristina Cadoni, Daniele Lecca, Laura Orsolini, Duccio Papanti, John Corkery, Fabrizio Schifano
Cannabis is the illicit drug with both the largest current levels of consumption and the highest lifetime prevalence in the world. Across different countries, the prevalence of cannabis use varies according to the individual income, with the highest use reported in North America, Australia and Europe. Despite its 'soft drug' reputation, cannabis misuse may be associated with several acute and chronic adverse effects. The present article aims at reviewing several papers on epidemiological, neurobiological and psychopathological aspects of the use of cannabis...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28363609/maternal-fetal-monitoring-of-opioid-exposed-pregnancies-analysis-of-a-pilot-community-based-protocol-and-review-of-the-literature
#19
Gareth Ryan, Joe Dooley, Rory Windrim, Megan Bollinger, Lianne Gerber Finn, Len Kelly
OBJECTIVES: To describe/analyse a novel, community-based prenatal monitoring protocol for opioid-exposed pregnancies developed by our centre in 2014 to optimize prenatal care for this population. A literature review of published monitoring protocols for this population is also presented. METHODS: Retrospective comparison of pre-protocol (n = 215) and post-protocol (n = 251) cohorts. Medline and Embase were searched between 2000-2016 using MeSH terms: [fetal monitoring OR prenatal care] AND [opioid-related disorders OR substance-related disorders] in Medline and [fetal monitoring OR prenatal care] AND [opiate addiction OR substance abuse] in Embase, producing 518 results...
June 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28343423/management-of-precipitated-opiate-withdrawal-syndrome-induced-by-nalmefene-mistakenly-prescribed-in-opiate-dependent-patients-a-review-for-clinicians
#20
REVIEW
Nicolas Franchitto, Benedicte Jullian, Juliette Salles, Fanny Pelissier, Benjamin Rolland
Nalmefene, a long-acting µ-opioid antagonist approved to treat alcohol use disorder, is occasionally mistakenly prescribed to opiate-dependent or opioid-treated patients. We review recent literature on drug-drug interactions between nalmefene and opioids that lead to precipitated opioid withdrawal, and focus on its management and planning for care at discharge. Areas covered: This article provides a brief and comprehensive review of management of precipitated opioid withdrawal syndrome when nalmefene is associated with an opioid, whether misused or legally prescribed...
June 2017: Expert Opinion on Drug Metabolism & Toxicology
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