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https://www.readbyqxmd.com/read/29215383/mood-stabilizing-anticonvulsants-spina-bifida-and-folate-supplementation-commentary
#1
Neil Patel, Adele C Viguera, Ross J Baldessarini
PURPOSE/BACKGROUND: High risks of neural tube defects and other teratogenic effects are associated with exposure in early pregnancy to some anticonvulsants, including in women with bipolar disorder. METHODS/PROCEDURES: Based on a semistructured review of recent literature, we summarized findings pertaining to this topic. FINDINGS/RESULTS: Valproate and carbamazepine are commonly used empirically (off-label) for putative long-term mood-stabilizing effects...
December 6, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29214704/definition-of-the-term-mood-stabilizer
#2
Terence A Ketter
No abstract text is available yet for this article.
December 7, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29212069/cellular-effects-of-the-antiepileptic-drug-valproic-acid-in-glioblastoma
#3
Marita Eckert, Lukas Klumpp, Stephan Huber
BACKGROUND/AIMS: Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug is used to treat epileptic seizure of glioblastoma patients. Besides its antiepileptic activity, VPA has been attributed further functions that improve the clinical outcome of glioblastoma patients. Those comprise the inhibition of some histone deacetylase (HDAC) isoforms which reportedly may result in radiosensitization. Retrospective analysis of patient data, however, could not unequivocally confirm a prolonged survival of glioblastoma patients receiving VPA...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29206349/mood-body-image-fear-of-kidney-failure-life-satisfaction-and-decisional-stability-following-living-kidney-donation-findings-from-the-kdoc-study
#4
J R Rodrigue, J D Schold, P Morrissey, J Whiting, J Vella, L K Kayler, D Katz, J Jones, B Kaplan, A Fleishman, M Pavlakis, D A Mandelbrot
Prior studies demonstrate that most living kidney donors (LKDs) report no adverse psychosocial outcomes; however, changes in psychosocial functioning at the individual donor level have not been routinely captured. We studied psychosocial outcomes pre-donation and at 1, 6, 12, and 24 months post-donation in 193 LKDs and 20 healthy controls (HCs). There was minimal to no mood disturbance, body image concerns, fear of kidney failure, or life dissatisfaction, indicating no incremental changes in these outcomes over time and no significant differences between LKDs and HCs...
December 5, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29205721/prophylactic-mood-stabilization-what-is-the-evidence-for-lithium-exposure-in-drinking-water
#5
Amine Awad, Andrea Cipriani
No abstract text is available yet for this article.
November 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29200666/prevention-of-memory-impairment-and-neurotrophic-factors-increased-by-lithium-in-wistar-rats-submitted-to-pneumococcal-meningitis-model
#6
Lutiana R Simões, Roberta R E S Abreu, Jaqueline S Generoso, Jéssica A Goularte, Allan Collodel, Vijayasree Vayalanellore Giridharan, Anitha Christy Sigamani Arumanayagam, Samira S Valvassori, João Quevedo, Tatiana Barichello
The aim of this study was to investigate the effects of lithium on brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell line-derived neurotrophic factor (GDNF) expression in the hippocampus and on memory in experimental pneumococcal meningitis. The mood-stabilizer lithium is known as a neuroprotective agent with many effects on the brain. In this study, animals received either artificial cerebrospinal fluid or Streptococcus pneumoniae suspension at a concentration of 5 × 109 CFU/mL...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29200553/sociodemographic-and-clinical-predictors-of-response-in-manic-episodes-a-naturalistic-prospective-cohort-study
#7
Jasmin Garg, Ajeet Sidana, B S Chavan, Shikha Goel
Background: Response to treatment of a manic episode is dependent on several sociodemographic and clinical factors as reported by researchers from other countries. The prescription of mood stabilizers and/or antipsychotics for manic episode depends on these factors. There is a lack of availability of data from India on this topic. Hence, this study was planned to identify the predictors of pharmacological response. Materials and Methods: Forty-two patients with a diagnosis of bipolar affective disorder current episode manic were enrolled and assessed for sociodemographic variables and clinical variables such as age of onset, family history, comorbidities, index episode, and number of past episodes...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29200548/mood-stabilisers-but-for-lithium-are-not-stabilizing-moods-bipolar-disorders-clinical-conundrums-2
#8
EDITORIAL
M S Reddy, Starlin Vijay Mythri, Swetha Reddy
No abstract text is available yet for this article.
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29199496/recent-trends-on-the-role-of-epigenomics-metabolomics-and-noncoding-rnas-in-rationalizing-mood-stabilizing-treatment
#9
Claudia Pisanu, Theodora Katsila, George P Patrinos, Alessio Squassina
Mood stabilizers are the cornerstone in treatment of mood disorders, but their use is characterized by high interindividual variability. This feature has stimulated intensive research to identify predictive biomarkers of response and disentangle the molecular bases of their clinical efficacy. Nevertheless, findings from studies conducted so far have only explained a small proportion of the observed variability, suggesting that factors other than DNA variants could be involved. A growing body of research has been focusing on the role of epigenetics and metabolomics in response to mood stabilizers, especially lithium salts...
December 4, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/29189421/asenapine-in-the-management-of-impulsivity-and-aggressiveness-in-bipolar-disorder-and-comorbid-borderline-personality-disorder-an-open-label-uncontrolled-study
#10
Andrea Aguglia, Ludovico Mineo, Alessandro Rodolico, Maria S Signorelli, Eugenio Aguglia
Borderline personality disorder (BPD) often co-occurres with bipolar disorder (BD). Impulsivity and aggressiveness represent core shared features and their pharmacological management is mainly based on mood stabilizers and antipsychotics, although scarce evidence is available for this context of comorbidity. The aim of the present study was to evaluate the role of Asenapine as an adjunctive drug for reducing aggressiveness and impulsivity in a sample of Italian BD type I outpatients with or without a comorbid BPD...
November 17, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29188151/arachnoid-cyst-and-psychosis
#11
Afaque H Khan, Syed E Ahmed
Few case reports discuss suspected psychiatric disturbances secondary to arachnoid cysts. To the best of our knowledge, psychosis from arachnoid cysts has not been reported in the recent literature. This case report discusses our experience with a 55-year-old male patient who manifested multiple psychotic episodes suspected in association with an arachnoid cyst. During the initial examinations, a computed tomography (CT) scan of his head revealed a relatively large left anterior superior arachnoid cyst with a mass effect on the frontal lobe...
September 21, 2017: Curēus
https://www.readbyqxmd.com/read/29188027/recent-advances-in-the-understanding-and-management-of-bipolar-disorder-in-adults
#12
REVIEW
Janusz K Rybakowski
This article focuses on some aspects of recent progress in the neurobiology and treatment of bipolar disorder (BD) in adults. A molecular-genetic approach to the etiopathogenesis of the illness resulted in the findings of a genetic overlap between BD and other major psychiatric disorders. Furthermore, a poly-gene-environmental interaction in the development of the illness has been demonstrated. For the management of BD, new drugs with putative mood-stabilizing properties have been introduced in the past two decades...
2017: F1000Research
https://www.readbyqxmd.com/read/29179438/valproate-hampers-podocyte-acquisition-of-immune-phenotypes-via-intercepting-the-gsk3%C3%AE-facilitated-nfkb-activation
#13
Pei Wang, Sijie Zhou, Yan Ge, Minglei Lu, Zhangsuo Liu, Rujun Gong
Glomerular podocytes are able to transdifferentiate under disease conditions, acquire de novo immune phenotypes and behave as immunocompetent cells, like phagocytes or antigen-presenting cells. Upon stimulation with lipopolysaccharide (LPS), a prototypical pathogen-associated molecular pattern, podocytes demonstrated de novo expression of a variety of NFkB-dependent immune molecules that are pivotal for immune response, including major histocompatibility complex (MHC) class II, costimulatory molecule CD80, lysosomal protease cathepsin L as well as CC chemokine ligand 2 and 5, ultimately resulting in podocyte dysfunction, characterized by cellular shrinkage, a spindle-like or asterlike cell shape and impairment of actin cytoskeleton integrity...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29175881/sing-your-heart-out-community-singing-as-part-of-mental-health-recovery
#14
Tom Shakespeare, Alice Whieldon
This paper reports on a qualitative evaluation of a Norfolk-based network of community singing workshops aimed at people with mental health conditions and the general public. The aims of the study were (a) to evaluate the effectiveness of the Sing Your Heart Out (SYHO) project and (b) to identify the key features which made the project distinctive. The study draws on 20 interviews with participants, two focus groups with organisers and workshop leaders, and participative observation over a 6-month period. Interviewees all reported improvement in or maintenance of their mental health and well-being as a direct result of engagement in the singing workshops...
November 25, 2017: Medical Humanities
https://www.readbyqxmd.com/read/29174949/impaired-repair-of-dna-damage-is-associated-with-autistic-like-traits-in-rats-prenatally-exposed-to-valproic-acid
#15
Michela Servadio, Antonia Manduca, Francesca Melancia, Loris Leboffe, Sara Schiavi, Patrizia Campolongo, Maura Palmery, Paolo Ascenzi, Alessandra di Masi, Viviana Trezza
Prenatal exposure to the antiepileptic and mood stabilizer valproic acid (VPA) is an environmental risk factor for autism spectrum disorders (ASD), although recent epidemiological studies show that the public awareness of this association is still limited. Based on the clinical findings, prenatal VPA exposure in rodents is a widely used preclinical model of ASD. However, there is limited information about the precise biochemical mechanisms underlying the link between ASD and VPA. Here, we tested the effects of increasing doses of VPA on behavioral features resembling core and secondary symptoms of ASD in rats...
November 23, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29174738/symptoms-and-functioning-with-aripiprazole-once-monthly-injection-as-maintenance-treatment-for-bipolar-i-disorder
#16
Joseph R Calabrese, Raymond Sanchez, Na Jin, Joan Amatniek, Kevin Cox, Brian Johnson, Pamela Perry, Peter Hertel, Pedro Such, Robert D McQuade, Margaretta Nyilas, William H Carson
BACKGROUND: Effects of maintenance treatment with aripiprazole once-monthly 400mg (AOM 400) on symptoms and functioning were assessed in adults with bipolar I disorder (BP-I) after a manic episode. METHODS: Patients were stabilized on oral aripiprazole, cross-titrated to AOM 400, then randomized in a 52-week, double-blind, placebo-controlled, withdrawal phase. Prespecified secondary outcomes are reported: time to hospitalization for mood episode, Young Mania Rating Scale (YMRS), Montgomery-Åsberg Depression Rating Scale (MADRS), Clinical Global Impression-Bipolar scale, Functioning Assessment Short Test (FAST), and Brief Quality of Life in Bipolar Disorder questionnaire...
October 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29173781/psychopharmacology-of-bipolar-disorders-in-children-and-adolescents
#17
REVIEW
Ekaterina Stepanova, Robert L Findling
Bipolar disorder is a debilitating illness that often leads to functional impairment when untreated. Monotherapy with mood stabilizers is preferable, although combination therapy may be necessary in refractory cases. Most studies focus on the use of lithium, anticonvulsants, and second-generation antipsychotics in the treatment of acute manic or depressive phases, as well as maintaining adequate response after the episode. More research is needed in the area of psychopharmacology of pediatric bipolar disorder to bridge the gap between clinical needs and the available data...
December 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/29167038/oral-contraceptives-positively-affect-mood-in-healthy-pms-free-women-a-longitudinal-study
#18
Danielle A Hamstra, E Ronald de Kloet, Mischa de Rover, Willem Van der Does
OBJECTIVE: Menstrual cycle phase and oral contraceptives (OC) use influence mood and cognition and these effects may be moderated by the mineralocorticoid receptor (MR) genotype. The effect of menstrual cycle phase on mood may be increased if participants know that this is the focus of study. We assessed aspects associated with reproductive depression such as mood, interpersonal sensitivity, affect lability and depressive cognitions in MR-genotyped OC-users and naturally cycling (NC) women in a carefully masked design...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29157006/chronotype-description-in-search-of-a-solid-subjective-amplitude-scale
#19
Halszka Oginska, Justyna Mojsa-Kaja, Olivier Mairesse
The term "subjective circadian amplitude" refers to the range or the distinctness of diurnal variations of arousal, that is, the awareness (or lack thereof) of difference between hyper- and hypo-activation phases, the ability to volitionally modulate one's own psychophysiological state, the strength of morning-evening preferences and flexibility of the rhythm or perceived stability of the circadian phase. The complexity of this construct is the source of difficulties in research and measurement. The psychometric features of distinctness subscales of the Chronotype Questionnaire and the Caen Chronotype Questionnaire are not satisfactory...
November 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29156592/activation-of-trek-1-but-not-trek-2-channel-by-mood-stabilizers
#20
Eun-Jin Kim, Dong Kun Lee, Seong-Geun Hong, Jaehee Han, Dawon Kang
Earlier studies have demonstrated that the tandem pore domain weak inward rectifying K⁺ channel (TWIK)-related K⁺ (TREK)-1 channel is inhibited by antidepressants and is associated with major depression. However, little is known about the effect of mood stabilizers that are commonly used for treatment of bipolar disorder on TREK channels, members of the two-pore domain K⁺ (K2P) channel family. This study sought to investigate the effect of mood stabilizers on TREK-1 and TREK-2 channels. HEK-293A cells were transfected with human TREK-1 or TREK-2 DNA...
November 19, 2017: International Journal of Molecular Sciences
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