Ludovic Trefond, Raphael Lhote, Alexis Mathian, Marc Pineton de Chambrun, Micheline Pha, Miguel Hie, Makoto Miyara, Matthias Papo, Quentin Moyon, Dov Taieb, Sonia Saade, Thouraya Ben Salem, Julien Haroche, François Chasset, Fleur Cohen Aubart, Noël Zahr, Zahir Amoura
BACKGROUND: Long-term hydroxychloroquine (HCQ) or chloroquine (CQ) intake causes retinal toxicity in 0.3-8 % of patients with rheumatic diseases. Numerous risk factors have been described, eg, daily dose by weight, treatment duration, chronic kidney disease, concurrent tamoxifen therapy and pre-existing retinal or macular disease. However, those factors cannot explain the entire risk of developing antimalarial retinopathy. OBJECTIVE: This study was undertaken to identify new risk factors associated with HCQ or CQ retinopathy (QRNP) in systemic lupus erythematosus (SLE) patients...
February 12, 2024: Seminars in Arthritis and Rheumatism