Ornella Cuomo, Giuseppe Pignataro, Rosaria Gala, Francesca Boscia, Anna Tortiglione, Pasquale Molinaro, Gianfranco Di Renzo, Jonathan Lytton, Lucio Annunziato
Sodium/calcium exchangers are neuronal plasma membrane transporters, which by coupling Ca2+ and Na+ fluxes, may play a relevant role in brain ischemia. The exchanger gene superfamily comprises two arms: the K+-independent (NCX) and K+-dependent (NCKX) exchangers. In the brain, three different NCX (NCX1, NCX2, NCX3) and three NCKX (NCKX2, NCKX3, NCKX4) family members have been described. Up to now, no sutides about the role played by NCKX proteins in cerebral ischemia have been published. The aim of the present study was to investigate the role of NCKX2 in an in vivo model of permanent middle cerebral artery occlusion (pMCAO)...
March 2007: Annals of the New York Academy of Sciences