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Crack cocaine and neuronal damage

D J Meyerhoff, C Bloomer, N Schuff, F Ezekiel, D Norman, W Clark, M W Weiner, G Fein
Chronic abuse of cocaine or alcohol is associated with structural, neuropathological and cognitive impairments that have been documented extensively. Little is known, however, about neurobiochemical changes in chronic substance abusers.We performed MRI and multi-slice brain proton magnetic resonance spectroscopic imaging (MRSI) to assess neuronal viability (via N-acetylaspartate (NAA)) and white matter metabolite status in 22 4-months-abstinent individuals dependent on crack cocaine only and on both crack cocaine and alcohol...
October 1999: Addiction Biology
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