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Spinal glial cells

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https://www.readbyqxmd.com/read/28337574/the-rs504393-influences-the-level-of-nociceptive-factors-and-enhances-opioid-analgesic-potency-in-neuropathic-rats
#1
Klaudia Kwiatkowski, Anna Piotrowska, Ewelina Rojewska, Wioletta Makuch, Joanna Mika
Increasing evidence has indicated that activated glial cells releasing nociceptive factors, such as interleukins and chemokines, are of key importance for neuropathic pain. Significant changes in the production of nociceptive factors are associated with the low effectiveness of opioids in neuropathic pain. Recently, it has been suggested that CCL2/CCR2 signaling is important for nociception. Here, we studied the time course changes in the mRNA/protein level of CD40/Iba-1, CCL2 and CCR2 in the spinal cord/dorsal root ganglia (DRG) in rats following chronic constriction injury (CCI) of the sciatic nerve...
March 23, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28334550/geraniol-promotes-functional-recovery-and-attenuates-neuropathic-pain-in-rats-with-spinal-cord-injury
#2
Yan Lv, Liang Zhang, Na Li, Naiken Mai, Yu Zhang, Shuyi Pan
Geraniol, a plant derived monoterpene, has been extensively studied and showed a wide variety of beneficial effects. The aim of this study was to investigate the therapeutic effect of geraniol on functional recovery and neuropathic pain in rats with spinal cord injury (SCI). Rats received a clip-compression SCI and were treated with geraniol 6 hours following SCI. Treatment of SCI rats with geraniol markedly improved locomotor function, and reduced sensitivity to the mechanical allodynia and thermal hyperalgesia...
March 23, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28326946/polyamidoamine-dendrimer-conjugated-triamcinolone-acetonide-attenuates-nerve-injury-induced-spinal-cord-microglia-activation-and-mechanical-allodynia
#3
Hwisung Kim, Boomin Choi, Hyoungsub Lim, Hyunjung Min, Jae Hoon Oh, Sunghyun Choi, Joung Goo Cho, Jong-Sang Park, Sung Joong Lee
Background Accumulating evidence on the causal role of spinal cord microglia activation in the development of neuropathic pain after peripheral nerve injury suggests that microglial activation inhibitors might be useful analgesics for neuropathic pain. Studies also have shown that polyamidoamine dendrimer may function as a drug delivery vehicle to microglia in the central nervous system. In this regard, we developed polyamidoamine dendrimer-conjugated triamcinolone acetonide, a previously identified microglial activation inhibitor, and tested its analgesic efficacy in a mouse peripheral nerve injury model...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28326927/glial-activation-in-the-collagenase-model-of-nociception-associated-with-osteoarthritis
#4
Sara Adães, Lígia Almeida, Catarina S Potes, Ana Rita Ferreira, José M Castro-Lopes, Joana Ferreira-Gomes, Fani L Neto
Background Experimental osteoarthritis entails neuropathic-like changes in dorsal root ganglia (DRG) neurons. Since glial activation has emerged as a key player in nociception, being reported in numerous models of neuropathic pain, we aimed at evaluating if glial cell activation may also occur in the DRG and spinal cord of rats with osteoarthritis induced by intra-articular injection of collagenase. Methods Osteoarthritis was induced by two injections, separated by three days, of 500 U of type II collagenase into the knee joint of rats...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28319259/label-free-identification-of-the-microstructure-of-rat-spinal-cords-based-on-nonlinear-optical-microscopy
#5
C X Liao, Z Y Wang, Y Zhou, L Q Zhou, X Q Zhu, W G Liu, J X Chen
The spinal cord is a vital link between the brain and the body and mainly comprises neurons, glial cells and nerve fibres. In this work, nonlinear optical (NLO) microscopy based on intrinsic tissue properties was employed to label-freely analyze the cells and matrix in spinal cords at a molecular level. The high-resolution and high-contrast NLO images of unstained spinal cords demonstrate that NLO microscopy has the ability to show the microstructure of white and grey matter including ventral horn, intermediate area, dorsal horns, ventral column, lateral column and dorsal column...
March 20, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28315275/sigma-1-receptor-in-motoneuron-disease
#6
Renzo Mancuso, Xavier Navarro
Amyotrophic Lateral Sclerosis (ALS ) is a neurodegenerative disease affecting spinal cord and brain motoneurons , leading to paralysis and early death. Multiple etiopathogenic mechanisms appear to contribute in the development of ALS , including glutamate excitotoxicity, oxidative stress , protein misfolding, mitochondrial defects, impaired axonal transport, inflammation and glial cell alterations. The Sigma-1 receptor is highly expressed in motoneurons of the spinal cord, particularly enriched in the endoplasmic reticulum (ER) at postsynaptic cisternae of cholinergic C-terminals...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28304238/remote-motor-system-metabolic-profile-and-surgery-outcome-in-cervical-spondylotic-myelopathy
#7
Sorin C Craciunas, Mircea R Gorgan, Bogdan Ianosi, Phil Lee, Joseph Burris, Carmen M Cirstea
OBJECTIVE In patients with cervical spondylotic myelopathy (CSM), the motor system may undergo progressive functional/structural changes rostral to the lesion, and these changes may be associated with clinical disability. The extent to which these changes have a prognostic value in the clinical recovery after surgical treatment is not yet known. In this study, magnetic resonance spectroscopy (MRS) was used to test 2 primary hypotheses. 1) Based on evidence of corticospinal and spinocerebellar, rubro-, or reticulospinal tract degeneration/dysfunction during chronic spinal cord compression, the authors hypothesized that the metabolic profile of the primary motor cortices (M1s) and cerebellum, respectively, would be altered in patients with CSM, and these alterations would be associated with the extent of the neurological disabilities...
March 17, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28300871/glial-scar-modulation-as-therapeutic-tool-in-spinal-cord-injury-in-animal-models
#8
Jéssica Rodrigues Orlandin, Carlos Eduardo Ambrósio, Valéria Maria Lara
PURPOSE: Spinal Cord injury represents, in veterinary medicine, most of the neurological attendances and may result in permanent disability, death or euthanasia. Due to inflammation resulting from trauma, it originates the glial scar, which is a cell interaction complex system. Its function is to preserve the healthy circuits, however, it creates a physical and molecular barrier that prevents cell migration and restricts the neuroregeneration ability. METHODS: This review aims to present innovations in the scene of treatment of spinal cord injury, approaching cell therapy, administration of enzyme, anti-inflammatory, and other active principles capable of modulating the inflammatory response, resulting in glial scar reduction and subsequent functional improvement of animals...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28296347/gdnf-schwann-cells-in-hydrogel-scaffolds-promote-regional-axon-regeneration-remyelination-and-functional-improvement-after-spinal-cord-transection-in-rats
#9
Bingkun K Chen, Nicolas N Madigan, Jeffrey S Hakim, Mahrokh Dadsetan, Siobhan S McMahon, Michael J Yaszemski, Anthony J Windebank
Positively-charged oligo[poly(ethylene glycol)fumarate] (OPF(+) ) is a biodegradable hydrogel used for spinal cord injury repair. We compared scaffolds containing primary Schwann cells (SCs) to scaffolds delivering SCs genetically modified to secrete high concentrations of glial cell-derived neurotrophic factor (GDNF). Multichannel OPF(+) scaffolds loaded with SCs or GDNF-SCs were implanted into transected rat spinal cords for 4 weeks. GDNF-SCs promoted regeneration of more axons into OPF(+) scaffolds (2773...
March 10, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28293643/neutrophils-infiltrate-the-spinal-cord-parenchyma-of-rats-with-experimental-diabetic-neuropathy
#10
Victoria L Newton, Jonathan D Guck, Mary A Cotter, Norman E Cameron, Natalie J Gardiner
Spinal glial cell activation and cytokine secretion have been implicated in the etiology of neuropathic pain in a number of experimental models, including diabetic neuropathy. In this study, streptozotocin- (STZ-) induced diabetic rats were either untreated or treated with gabapentin (50 mg/kg/day by gavage for 2 weeks, from 6 weeks after STZ). At 8 weeks after STZ, hypersensitivity was confirmed in the untreated diabetic rats as a reduced response threshold to touch, whilst mechanical thresholds in gabapentin-treated diabetic rats were no different from controls...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28290147/temporal-profile-and-severity-correlation-of-a-panel-of-rat-spinal-cord-injury-protein-biomarkers
#11
Zhihui Yang, Helen M Bramlett, Ahmed Moghieb, Dongnan Yu, Ping Wang, Fan Lin, Carl Bauer, Tyler M Selig, Emily Jaalouk, Amanda S Weissman, Disa S Rathore, Pammela Romo, Zhiqun Zhang, Ronald L Hayes, Michael Y Wang, W Dalton Dietrich, Kevin K W Wang
In the USA, there are approximately 12,000 new cases of spinal cord injury (SCI) each year and some 1.2 million people living with paralysis due to SCI. Seven percent of them are paralyzed due to an accident or injury occurring while serving in the military. Here, we report a systematic study on protein biomarker candidates in a rat SCI model with either moderate or severe injury. Tissue, cerebrospinal fluid (CSF), and serum samples were obtained at 4 h, 24 h, and 7 days post-injury. The candidate biomarkers included axonal injury markers αII-spectrin breakdown products (SBDP150/145/120), neuronal cell body injury marker ubiquitin C-terminal hydrolase-L1 (UCH-L1), astrogliosis/astroglial injury markers S100 calcium-binding protein-β (S100β), glial fibrillary acidic protein (GFAP) and GFAP breakdown products (GBDPs), demyelination marker myelin basic protein (MBP), axonal injury marker phosphorylated neurofilament-H (pNF-H), and neuroinflammation marker interleukin-6 (IL-6)...
March 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28290135/spinal-cord-injury-impairs-neurogenesis-and-induces-glial-reactivity-in-the-hippocampus
#12
Ignacio Jure, Luciana Pietranera, Alejandro F De Nicola, Florencia Labombarda
The incorporation of newborn neurons with increased synaptic remodeling and activity-dependent plasticity in the dentate gyrus enhances hippocampal-dependent learning performances. Astrocytes and microglial cells are components of the neurogenic niche and regulate neurogenesis under normal and neurophatological conditions leading to functional consequences for learning and memory. Although cognitive impairments were reported in patients after spinal cord injury (SCI), only few studies have considered remote changes in brain structures which are not related with sensory and motor cortex...
March 13, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28285347/endothelin-1-induces-degeneration-of-cultured-motor-neurons-through-a-mechanism-mediated-by-nitric-oxide-and-pi3k-akt-pathway
#13
S D'Antoni, E Ranno, M Spatuzza, S Cavallaro, M V Catania
Endothelin-1 (ET-1) is a vasoactive peptide produced by activated astrocytes and microglia and is implicated in initiating and sustaining reactive gliosis in neurodegenerative diseases. We have previously suggested that ET-1 can play a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). Indeed, we reported that this peptide is abundantly expressed in reactive astrocytes in the spinal cord of SOD1-G93A mice and ALS patients and exerts a toxic effect on motor neurons (MNs) in an in vitro model of mixed spinal cord cultures enriched with reactive astrocytes...
March 11, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28281545/il-17-induces-reactive-astrocytes-and-up-regulation-of-vascular-endothelial-growth-factor-vegf-through-jak-stat-signaling
#14
Tao You, Yihui Bi, Jun Li, Mingkai Zhang, Xuezhou Chen, Keke Zhang, Jun Li
Spinal cord injury is a grave neurological disability resulting in neuron degeneration and permanent paralysis. The inflammation triggered by the injury would promote the spinal cord lesion in turn. Activated astrocytes during inflammatory response could promote glial scar formation and contribute to the progression of the spinal cord injury. Interleukin 17 (IL-17) was upregulated in inflammatory responses to contusion or compression of the spinal cord. in this study, IL-17 could induce reactive astrocytes which was indicated by a well-known hallmark glial fibrillary acidic protein (GFAP) in vitro and in vivo...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274846/acute-granulocyte-macrophage-colony-stimulating-factor-treatment-modulates-neuroinflammatory-processes-and-promotes-tactile-recovery-after-spinal-cord-injury
#15
Sandie Thomaty, Laurent Pezard, Christian Xerri, Jean-Michel Brezun
Neuroinflammation is known to play a key role in the prognosis of functional recovery after spinal cord injury (SCI). The involvement of microglial and mast cells in early and late stages of inflammation has been receiving increasing attention. This study was aimed at determining the influence of a pro-inflammatory cytokine, the granulocyte macrophage-colony stimulating factor (GM-CSF), on microglia and mast cell activation, glial scar formation and functional recovery following SCI. Rats were randomly injected with saline or GM-CSF one hour after a C4-C5 medio-lateral hemisection...
March 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/28273090/fingolimod-effects-in-neuroinflammation-regulation-of-astroglial-glutamate-transporters
#16
De-Hyung Lee, Silvia Seubert, Konstantin Huhn, Lukas Brecht, Caroline Rötger, Anne Waschbisch, Johannes Schlachetzki, Alice Klausmeyer, Arthur Melms, Stefan Wiese, Jürgen Winkler, Ralf A Linker
Fingolimod is an oral sphingosine-1-phosphate-receptor modulator which reduces the recirculation of immune cells and may also directly target glial cells. Here we investigate effects of fingolimod on expression of astroglial glutamate transporters under pro-inflammatory conditions. In astrocyte cell culture, the addition of pro-inflammatory cytokines led to a significant downregulation of glutamate transporters glutamate transporter-1 (slc1a2/SLC1A2) and glutamate aspartate transporter (slc1a3/SLC1A3) expression on the mRNA or protein level...
2017: PloS One
https://www.readbyqxmd.com/read/28270702/unconventional-role-of-caspase-6-in-spinal-microglia-activation-and-chronic-pain
#17
REVIEW
Temugin Berta, Jee Eun Lee, Chul-Kyu Park
Chronic pain affects ~20% of the worldwide population. The clinical management of chronic pain is mostly palliative and results in limited success. Current treatments mostly target the symptoms or neuronal signaling of chronic pain. It has been increasingly recognized that glial cells, such as microglia, and inflammatory signaling play a major role in the pathogenesis of chronic pain. Caspases (CASPs) are a family of protease enzymes involved in apoptosis and inflammation. They are pivotal components in a variety of neurological diseases...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28267560/neurogenic-bladder-dysfunction-does-not-correlate-with-astrocyte-and-microglia-activation-produced-by-graded-force-in-a-contusion-induced-spinal-cord-injury
#18
Alvaro Munoz
Rodent models for the study of neurogenic bladder dysfunction after spinal cord injury (SCI) are difficult to standardize, particularly when evaluating the specific contribution of the SCI to end-organ function. The purpose of this study was to evaluate the degree of bladder dysfunction associated with a highly reproducible, contusion-induced SCI in female rats. An infinite horizon impactor was used to create a contusion SCI with a magnitude of either 100 or 150 kDyne at the T8/T9 thoracic region of female Sprague-Dawley rats...
March 3, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28262732/transplantation-of-huc-mscs-seeded-collagen-scaffolds-reduces-scar-formation-and-promotes-functional-recovery-in-canines-with-chronic-spinal-cord-injury
#19
Xing Li, Jun Tan, Zhifeng Xiao, Yannan Zhao, Sufang Han, Dingyang Liu, Wen Yin, Jing Li, Juan Li, Siyi Wanggou, Bing Chen, Caiping Ren, Xingjun Jiang, Jianwu Dai
Spinal cord injury (SCI) can lead to locomotor deficits, and the repair of chronic SCI is considered one of the most challenging clinical problems. Although extensive studies have evaluated treatments for acute SCI in small animals, comparatively fewer studies have been conducted on large-animal SCI in the chronic phase, which is more clinically relevant. Here, we used a collagen-based biomaterial, named the NeuroRegen scaffold, loaded with human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in a canine chronic SCI model...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254289/a-combination-of-gdnf-and-hucmsc-transplantation-loaded-on-sf-ags-composite-scaffolds-for-spinal-cord-injury-repair
#20
Genlong Jiao, Guofeng Lou, Yunfei Mo, Yongqin Pan, Ziyong Zhang, Rui Guo, Zhizhong Li
Spinal cord injury (SCI) is a severe trauma for which no effective treatment is currently available. In this study, a composited treatment system was prepared using a silk fibroin/alginates/glial cell line-derived neurotrophic factor (SF/AGs/GDNF) scaffold seeded with human umbilical cord mesenchymal stem cells (hUCMSCs) and the combined therapeutic effects of the composite scaffold to repair SCI rats were evaluated. The use of SF as a scaffold material could act as a biomimetic platform allowing neurons to properly accommodate and rebuild the target tissue...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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