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https://www.readbyqxmd.com/read/28448027/dry-powder-and-nebulized-aerosol-inhalation-of-pharmaceuticals-delivered-to-mice-using-a-nose-only-exposure-system
#1
Jonathan E Phillips, Xuxia Zhang, James A Johnston
Obstructive respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD) are currently treated by inhaled anti-inflammatory and bronchodilator drugs. Despite the availability of multiple treatments, both diseases are growing public health concerns. The majority of asthma patients are well controlled on current inhaled therapies but a substantial number of patients with severe asthma are not. Asthma affects an estimated 300 million people worldwide and approximately 20 percent have a severe form of the disease...
April 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447167/success-rate-of-natural-orifice-specimen-extraction-after-laparoscopic-colorectal-resections
#2
S Karagul, C Kayaalp, F Sumer, I Ertugrul, S Kirmizi, A Tardu, M A Yagci
PURPOSE: To date, no data have been available to inform which cases are appropriate for natural orifice specimen extraction (NOSE) after laparoscopic colorectal resections (LCRRs). Our aim was to evaluate the success rate and the factors affecting the failure in patients who were scheduled for NOSE after LCRRs. METHODS: Seventy-two consecutive cases that were intended for NOSE after LCRR were enrolled. The transanal route was always chosen as the first option, and when it failed, the transvaginal route was tried in female patients...
April 26, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28446669/salivary-blockade-protects-the-lower-respiratory-tract-of-mice-from-lethal-influenza
#3
Karen Ivinson, Georgia Deliyannis, Leanne McNabb, Lara Grollo, Brad Gilbertson, David Jackson, Lorena E Brown
It is possible to model progression of influenza virus from the upper respiratory tract to the lower respiratory tract in the mouse using viral inoculum delivered in a restricted manner to the nose. In this model, infection with the A/Udorn/307/72 (Udorn) strain of virus results ultimately in high viral titres in both the trachea and lungs. In contrast, the A/Puerto Rico/8/34 (PR8) strain causes an infection that is almost entirely limited to the nasal passages. The factors that govern the progression of virus down the respiratory tract are not well understood...
April 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28445360/facial-danger-zones-techniques-to-maximize-safety-during-soft-tissue-filler-injections
#4
Jack F Scheuer, David A Sieber, Ronnie A Pezeshk, Andrew A Gassman, Carey F Campbell, Rod J Rohrich
Given the short recovery and immediate results, facial fillers have become a popular alternative to surgical rejuvenation of the face. Reported complications arising from facial filler injections include erythema, tissue loss, blindness, stroke, and even death. In this article, the authors describe their anatomically based techniques to minimize risk and maximize safety when injecting in the facial danger zones, including the glabella/brow, temporal region, perioral region, nasolabial fold, nose, and infraorbital region...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445200/the-nasal-tip-rotation-flap-for-reconstruction-of-the-lateral-nasal-tip-anterior-ala-and-soft-triangle-the-authors-experience-with-55-patients
#5
Anastasia Benoit, S Tyler Hollmig, Brian C Leach
BACKGROUND: Defects of the lateral nasal tip, anterior ala, and soft triangle subunits lack reconstructive options that are consistently satisfactory. For such defects, the novel anterior-based nasal tip rotation flap provides functional and aesthetic results in a single operative session. OBJECTIVE: To describe the authors' experience with the nasal tip rotation flap, including patient selection and design modifications to enhance aesthetic success. METHODS: An IRB-approved retrospective database review of nasal tip rotation flap repairs was performed at the Medical University of South Carolina and Stanford University Medical Center...
April 24, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28444500/metastatic-follicular-thyroid-carcinoma-and-the-primary-thyroid-gross-examination-institutional-review-of-cases-from-1990-to-2015
#6
Krzysztof Glomski, Vania Nosé, William C Faquin, Peter M Sadow
The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less than a millimeter of tissue segregating them from adenomas and non-invasive follicular thyroid neoplasms with papillary-like nuclear features, opinions vary internationally over how much of the capsule to submit in order to deem it well enough represented, considering that even if grossly entirely submitted in microcassettes, without leveling through each tissue block, the capsule is truly never entirely examined microscopically...
April 25, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28444104/psychomotor-ability-and-short-term-memory-and-reading-and-mathematics-achievement-in-children
#7
Cherée Murrihy, Maria Bailey, John Roodenburg
Objective: The aim of our study was to examine whether the findings from previous research, indicating the role of short-term memory as a mediator of the relationship between motor coordination and academic achievement in adolescents, is also evident in a younger child population. Method: The study utilized a quantative cross-sectional design involving 133 children aged 8-12. The McCarron Assessment of Neuromuscular Development (MAND) provided four indicators of psychomotor ability (Finger Nose, Walking, Balancing, and Jumping)...
April 24, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28444021/evaluation-of-facial-attractiveness-in-black-people-according-to-the-subjective-facial-analysis-criteria
#8
Andréa Reis de Melo, Ana Cláudia de Castro Ferreira Conti, Renata Rodrigues Almeida-Pedrin, Victor Didier, Danilo Pinelli Valarelli, Leopoldino Capelozza Filho
OBJECTIVE: The objective of this study was to evaluate the facial attractiveness in 30 black individuals, according to the Subjective Facial Analysis criteria. METHODS: Frontal and profile view photographs of 30 black individuals were evaluated for facial attractiveness and classified as esthetically unpleasant, acceptable, or pleasant by 50 evaluators: the 30 individuals from the sample, 10 orthodontists, and 10 laymen. Besides assessing the facial attractiveness, the evaluators had to identify the structures responsible for the classification as unpleasant and pleasant...
February 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28443629/differences-in-peripheral-sensory-input-to-the-olfactory-bulb-between-male-and-female-mice
#9
Marley D Kass, Lindsey A Czarnecki, Andrew H Moberly, John P McGann
Female mammals generally have a superior sense of smell than males, but the biological basis of this difference is unknown. Here, we demonstrate sexually dimorphic neural coding of odorants by olfactory sensory neurons (OSNs), primary sensory neurons that physically contact odor molecules in the nose and provide the initial sensory input to the brain's olfactory bulb. We performed in vivo optical neurophysiology to visualize odorant-evoked OSN synaptic output into olfactory bub glomeruli in unmanipulated (gonad-intact) adult mice from both sexes, and found that in females odorant presentation evoked more rapid OSN signaling over a broader range of OSNs than in males...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28441829/-primary-ciliary-dyskinesia-with-hydin-gene-mutations-in-a-child-and-literature-review
#10
L L Chen, Y G Yang, J Z Wu, X R Chen
Objective: To review children's primary ciliary dyskinesia (PCD) in the pathogenesis, clinical manifestation, diagnosis and treatment. Method: To summarize and analyze the clinical data of a patient who was admitted to the first affiliated hospital of Xiamen University with primary ciliary dyskinesia in April 2014 while referring to related literature. Result: An 11 years old boy, weighting about 22 kg, had a course of more than 10 years with repeated cough, stuffy and runny nose shortly after the birth. Examinations after admission to hospital showed that he presented with visible clubbing, bilateral paranasal sinus area tenderness, pharynx posterior wall with visible yellow pussy stuff drip and bilateral lung had scattered wet rales...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28441423/reproductive-parameters-and-cub-survival-of-brown-bears-in-the-rusha-area-of-the-shiretoko-peninsula-hokkaido-japan
#11
Michito Shimozuru, Masami Yamanaka, Masanao Nakanishi, Jun Moriwaki, Fumihiko Mori, Masakatsu Tsujino, Yuri Shirane, Tsuyoshi Ishinazaka, Shinsuke Kasai, Takane Nose, Yasushi Masuda, Toshio Tsubota
Knowing the reproductive characteristics of a species is essential for the appropriate conservation and management of wildlife. In this study, we investigated the demographic parameters, including age of primiparity, litter size, inter-birth interval, reproductive rate, and cub survival rate, of Hokkaido brown bears (Ursus arctos yesoensis) in the Rusha area on the Shiretoko Peninsula, Hokkaido, Japan, based on a long-term, individual-based monitoring survey. A total of 15 philopatric females were observed nearly every year from 2006 to 2016, and these observations were used to estimate reproductive parameters...
2017: PloS One
https://www.readbyqxmd.com/read/28440960/is-humidified-better-than-non-humidified-low-flow-oxygen-therapy-a-systematic-review-and-meta-analysis
#12
REVIEW
Zunjia Wen, Wenting Wang, Haiying Zhang, Chao Wu, Jianping Ding, Meifen Shen
AIMS: To determine the effects of low-flow oxygen therapy with humidified or non-humidified oxygen in adult patients. BACKGROUND: Although non-humidified oxygen in low-flow oxygen therapy is recommended by many guidelines, humidifying oxygen regardless of oxygen flow has been routinely performed in China and Japan and further studies are needed to evaluate the evidence. DESIGN: A systematic review and meta-analysis that comply with the recommendations of the Cochrane Collaboration were conducted...
April 25, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28439976/eye-retraction-and-rotation-during-corvis-st-air-puff-intraocular-pressure-measurement-and-its-quantitative-analysis
#13
Agnieszka Boszczyk, Henryk Kasprzak, Agnieszka Jóźwik
PURPOSE: The aim of this study was to analyse the indentation and deformation of the corneal surface, as well as eye retraction, which occur during air puff intraocular pressure (IOP) measurement. METHODS: A group of 10 subjects was examined using a non-contact Corvis ST tonometer, which records image sequences of corneas deformed by an air puff. Obtained images were processed numerically in order to extract information about corneal deformation, indentation and eyeball retraction...
May 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28438259/variation-in-olfactory-neuron-repertoires-is-genetically-controlled-and-environmentally-modulated
#14
Ximena Ibarra-Soria, Thiago S Nakahara, Jingtao Lilue, Yue Jiang, Casey Trimmer, Mateus Aa Souza, Paulo Hm Netto, Kentaro Ikegami, Nicolle R Murphy, Mairi Kusma, Andrea Kirton, Luis R Saraiva, Thomas M Keane, Hiroaki Matsunami, Joel Mainland, Fabio Papes, Darren W Logan
The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000. Thus, the nose is sub-stratified into more than a thousand OSN subtypes. Here, we employ and validate an RNA-sequencing-based method to quantify the abundance of all OSN subtypes in parallel, and investigate the genetic and environmental factors that contribute to neuronal diversity. We find that the OSN subtype distribution is stereotyped in genetically identical mice, but varies extensively between different strains...
April 25, 2017: ELife
https://www.readbyqxmd.com/read/28437259/utility-of-esophageal-mucosal-impedance-as-a-diagnostic-test-for-esophageal-disease
#15
Dhyanesh A Patel, Michael F Vaezi
PURPOSE OF REVIEW: The aim of this review is to summarize the use of direct mucosal impedance (MI) for the evaluation and management of esophageal diseases. RECENT FINDINGS: Esophageal multichannel intraluminal impedance with pH (MII-pH) monitoring has been considered the most sensitive test for gastroesophageal reflux disease (GERD), but recent studies have failed to establish impedance parameters that reliably predict treatment response to medical and surgical GERD therapies...
April 21, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28436022/ventilation-via-the-2-4%C3%A2-mm-internal-diameter-tritube-%C3%A2-with-cuff%C3%A2-new-possibilities-in-airway-management
#16
REVIEW
M S Kristensen, M W P de Wolf, L S Rasmussen
BACKGROUND: A small tube may facilitate tracheal intubation and improve surgical access. We describe our initial experience with the Tritube(®) that is a novel cuffed endotracheal tube with a 2.4 mm internal diameter. METHODS: The Tritube(®) was used in seven adult Ear-Nose-and Throat surgical patients with airway narrowing or whose surgical access was facilitated by this small-bore endotracheal tube. Ventilation through Tritube(®) is performed with the manually operated Ventrain(®) -ventilator that allows active suctioning during expiration, therefore facilitating normoventilation through small diameter airways...
April 23, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28434058/medical-conditions-in-the-first-years-of-life-associated-with-future-diagnosis-of-asd-in-children
#17
Stacey E Alexeeff, Vincent Yau, Yinge Qian, Meghan Davignon, Frances Lynch, Phillip Crawford, Robert Davis, Lisa A Croen
This study examines medical conditions diagnosed prior to the diagnosis of autism spectrum disorder (ASD). Using a matched case control design with 3911 ASD cases and 38,609 controls, we found that 38 out of 79 medical conditions were associated with increased ASD risk. Developmental delay, mental health, and neurology conditions had the strongest associations (ORs 2.0-23.3). Moderately strong associations were observed for nutrition, genetic, ear nose and throat, and sleep conditions (ORs 2.1-3.2). Using machine learning methods, we clustered children based on their medical conditions prior to ASD diagnosis and demonstrated ASD risk stratification...
April 22, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28434014/prospective-open-label-evaluation-of-long-term-low-dose-doxycycline-for-difficult-to-treat-chronic-rhinosinusitis-with-nasal-polyps
#18
A C Pinto Bezerra Soter, T F Bezerra, R Pezato, T R Teles Abdo, R M Pilan, F R Pinna, P Gevaert, T van Zele, C Bachert, R L Voegels
BACKGROUND: This study aimed to assess clinical outcomes of long-term low-dose oral doxycycline therapy in difficult-to-treat chronic rhinosinusitis with polyps (CRSwNP). METHODS: This was a prospective, open-label study of 60 patients with difficult-to-treat CRSwNP who had undergone endoscopic sinus surgery. Patients were divided into two groups: 28 received nasal steroids, saline irrigation, and doxycycline (200 mg on the first day, followed by 100 mg once daily) for 12 weeks, while 30 received only nasal steroids and saline irrigation...
April 23, 2017: Rhinology
https://www.readbyqxmd.com/read/28432762/microvascular-replantation-of-head-and-neck-amputated-parts-a-systematic-review
#19
REVIEW
Johnny I Efanov, Ixchel J Montoya, Ke N Huang, Charles Guertin, Patrick G Harris, Joseph Bou-Merhi, Alain M Danino
BACKGROUND: As opposed to upper and lower extremity amputations representing a considerable volume of admissions, the prowess of microsurgeons is seldom solicited in complex cases of head and neck replantation. Our aim was to determine the rate of successful replantation of craniofacial parts in a systematic review of the literature. METHODS: We performed a systematic review of English literature using PubMed/MEDLINE for every replantation of a head and neck parts...
April 22, 2017: Microsurgery
https://www.readbyqxmd.com/read/28432416/commentary-on-3d-photogrammetric-analysis-of-the-nasal-tip-projection-and-derotation-based-on-the-nasal-tip-quadripod-concept
#20
Cerkes Nazım
Asian noses are mainly characterized by a low nasal dorsum, a short nose and an underprojected nasal tip due to underdeveloped (short and weak) alar cartilages. The goals of the surgery are to increase the tip projection, elongate the nose and augment the dorsum. In Asian noses the structural approach helps strengthen the weak cartilages and add definition to the nasal tip. There are various methods to increase tip projection and definition. Columellar strut, caudal septal extension graft, tip grafts and lateral crural grafts in order to elongate the upper legs of the nasal tip tripod can be used...
April 21, 2017: Aesthetic Plastic Surgery
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