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https://www.readbyqxmd.com/read/28231590/endotypes-in-chronic-rhinosinusitis-biomarkers-based-on-a-mechanistic-insight-for-targeted-treatment
#1
Martin Wagenmann, Kathrin Scheckenbach, Adam M Chaker
Chronic rhinosinusitis is an umbrella term for several phenotypes and mechanistically distinct inflammatory diseases of the nose and the paranasal sinuses affecting around 11% of the population in Europe and the USA. Approximately 20% of the patients present with uncontrolled disease despite adequate treatment, and revision surgery is common. While a clinical characterization alone does not improve treatment results, novel but expensive biologics have increasingly become available, but they require a better understanding of the mechanism...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28231381/hippocampal-prefrontal-theta-phase-synchrony-in-planning-of-multi-step-actions-based-on-memory-retrieval
#2
Seiya Ishino, Susumu Takahashi, Masaaki Ogawa, Yoshio Sakurai
Planning of multi-step actions based on the retrieval of acquired information is essential for efficient foraging. The hippocampus (HPC) and prefrontal cortex (PFC) may play critical roles in this process. However, in rodents, many studies investigating such roles utilized T-maze tasks that only require one-step actions (i.e., selection of one of two alternatives), in which memory retrieval and selection of an action based on the retrieval cannot be clearly differentiated. In monkeys, PFC has been suggested to be involved in planning of multi-step actions; however, the synchrony between HPC and PFC has not been evaluated...
February 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28231370/significance-of-imaging-in-the-diagnosis-of-olfactory-disorder
#3
Teemu Harju, Markus Rautiainen, Ilkka Kivekäs
The aim of this retrospective analysis was to examine olfactory disorders among the patients in the Ear, Nose, and Throat Clinic of Tampere University Hospital, Finland, from 2001 to 2011, and to evaluate the necessity of imaging in the examination of patients with olfactory disorders. Charts of 143 consecutive patients with a primary olfactory disorder were examined, and 69 patients who had undergone the necessary testing were included in the study. The most common causes of olfactory disorder were upper respiratory infection (23%), chronic rhinosinusitis (19%), head trauma (17%), and allergic or nonallergic rhinitis (6%)...
February 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28231369/estimation-of-partitioning-of-airflow-in-septal-surgery-a-prospective-study-with-reference-to-the-nose-scale
#4
Indranil Sen, Mainak Dutta, Dibakar Haldar, Ramanuj Sinha
Improper patient selection for septal surgery often has been found to result in therapeutic failure, and there needs to be an objective assessment of nasal obstruction before the surgery and for postoperative follow-up that can be applied in the routine otolaryngology practice. The purpose of this study is to assess the usefulness of a cost-effective device for objective measurement of the nasal airway partitioning in selecting patients for septal surgery and for postoperative outcome evaluation. A hospital-based, prospective, observational study was carried out in a tertiary-care teaching institution involving 74 patients waiting for septal surgery...
February 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28231133/soybean-enriched-snacks-based-on-african-rice
#5
Mauro Marengo, Hannah F Akoto, Miriam Zanoletti, Aristodemo Carpen, Simona Buratti, Simona Benedetti, Alberto Barbiroli, Paa-Nii T Johnson, Esther O Sakyi-Dawson, Firibu K Saalia, Francesco Bonomi, Maria Ambrogina Pagani, John Manful, Stefania Iametti
Snacks were produced by extruding blends of partially-defatted soybean flour with flours from milled or parboiled African-grown rice. The interplay between composition and processing in producing snacks with a satisfactory sensory profile was addressed by e-sensing, and by molecular and rheological approaches. Soybean proteins play a main role in defining the properties of the protein network in the products. At the same content in soybean flour, use of parboiled rice flour increases the snack's hardness. Electronic nose and electronic tongue discriminated samples containing a higher amount of soybean flour from those with a lower soybean flour content...
May 20, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230902/comparison-among-manual-facial-approximations-conducted-by-two-methodological-approaches-of-face-prediction
#6
Lara Maria Herrera, Raíssa Ananda Paim Strapasson, Alice Aquino Zanin, Jorge Vicente Lopes da Silva, Rodolfo Francisco Haltenhoff Melani
This study verified the difference between two methods of forensic facial approximation (FFA) regarding recognition and resemblance rates. Three-dimensional models of skulls were obtained from computerized tomography (CT) scans of two subjects (targets). Two manual FFAs were performed for each target, by applying two different guidelines for the facial structures (what we called "American method" (AM) and "Combined method" (CM)). Unfamiliar assessors evaluated the sculptures by recognition and resemblance tests...
February 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28230602/subcutaneous-c-shape-muscular-flap-for-correcting-the-depression-of-alar-base-in-affected-side-in-patients-with-unilateral-complete-cleft-lip-palate-during-primary-surgery
#7
Dandan Wu, Guomin Wang, Ningjuan Ouyang, Yuhen Lin, Yang Chen, Jiewen Dai
PURPOSE: The depression of alar base in affected side in patients with unilateral complete cleft lip/palate (CL/P) is one of common clinical features. In this study, the authors try to explore the effect of subcutaneous C shape muscular flap for correcting the depression of alar base in affected side in patients with unilateral complete CL/P during primary surgery. METHODS: A total of 30 patients with unilateral complete CL/P who received primary correction of the lip nose deformity were included in this study...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28229115/data-on-the-auditory-duration-mismatch-negativity-for-different-sound-pressure-levels-and-visual-perceptual-loads
#8
Stefan Wiens, Malina Szychowska, Rasmus Eklund, Mats E Nilsson
The data presented in this article are related to our research article entitled "Effects of sound pressure level and visual perceptual load on the auditory mismatch negativity" (M. Szychowska, R. Eklund, M.E. Nilsson, S. Wiens, 2016) [1]. The duration MMN was recorded at three sound pressure levels (SPLs) during two levels of visual perceptual load. In an oddball paradigm (standard=75 ms, deviant=30 ms, within-subjects design), participants were presented with tones at 56, 66, or 76 dB SPL (between-subjects design)...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28227688/development-of-a-finger-like-mechanism-of-end-effector-for-micro-surgery
#9
S M Kim, C M Park, J H Yoo, K Kim, S M Kim, C M Park, J H Yoo, K Kim, J H Yoo, K Kim, C M Park, S M Kim
Neurosurgery had been considered nearly impossible due to its technical difficulty and the danger to its special target organ, but with endoscopic methods, many such surgeries can be made safely through the nose. Endoscopic neurosurgery is limited by available instruments, however, and there remain some areas of the human body inaccessible to standard surgical tools. To overcome some of these limitations, in this study we developed a simple mechanism that could form a high curvature in a narrow space. The end product is a finger-like mechanism consisting of five body parts and four joints...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226375/trends-in-nasal-subunit-reconstruction-by-facial-plastic-and-reconstructive-surgeons
#10
Yuna C Larrabee, David J Phillips, Anthony P Sclafani
To determine if facial plastic and reconstructive surgeons still adhere to the classic nasal subunit principle as described by Burget and Menick. Observational survey. A Weill Cornell Medicine institutional review board approved electronic survey that was sent via e-mail to active members of the American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS). The survey consisted of 32 multiple-choice questions pertaining to the operative management of small (22-30%), medium (50-58%), and large (75-81%) defects of each subunit of the nose, as well as demographic, provider, and practice characteristics...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226373/microvascular-flaps-in-nasal-reconstruction
#11
Irene A Kim, Kofi D O Boahene, Patrick J Byrne, Shaun C Desai
Nasal reconstruction for subtotal and total rhinectomy defects is a challenging endeavor, which requires technical finesse, a keen artistic eye, and the ability to anticipate long-term changes that accompany postoperative healing. While local and regional flaps have traditionally been utilized to reconstitute missing nasal elements, certain situations may not provide sufficient or acceptable tissue for optimal reconstruction. In these situations, the three major components of the nose-lining, structural support, and external skin-may require reconstruction with tissues harvested from distant sites through microvascular free tissue transfer...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226371/nasal-reconstruction-involving-multiple-subunit-defects
#12
Artemus Cox, Matthew Fort
The challenges of nasal reconstruction are readily apparent to any surgeon who has undertaken this task. Defects involving multiple subunits of the nose usually require adjacent tissue transferred to the wound typically in the form of a forehead flap or other local flaps. Herein, we describe current thought on the subunit principle and the application of local flaps and grafts in reconstructing larger superficial defects of the nose. Primary attention is paid to analysis and patient counseling.
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226370/osseous-and-cartilaginous-nasal-reconstruction
#13
Samuel Hahn
The nose is a complex, three-dimensional structure that is supported by a framework of osseous and cartilaginous structures. Disruption of this framework can result in nasal deformity and functional deficits. Nasal reconstruction requires restoration of the osseous and cartilaginous framework. This requires careful preoperative assessment of the nasal defect and understanding the nasal and facial aesthetics that are supported by the osseous and cartilaginous support structures. Structural grafts can be classified as restorative, supportive, or contouring...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226369/interpolated-flaps
#14
Samkon Kaltho Gado, Kaveh Karimnejad, Ian A Maher, Paul J Gruber, Scott Walen
Nasal reconstruction has been articulated in the literature since 700 B.C. when the earliest iteration of the forehead flap was described in the Indian medical treatise, the Sushruta Samhita. Since then it has evolved into the interpolated flap which has served as a powerful tool for facial reconstruction. The interpolated flap is constructed from nonadjacent donor tissue that has an inherent blood supply. It requires a multistaged approach and is best suited for reconstruction of large or deep defects of the nose...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226366/principles-of-nasal-reconstruction
#15
Emily Spataro, Gregory H Branham
The rise in cutaneous malignancies over the past 20 years has led to significant advances in reconstructing the nose from an aesthetic and functional standpoint. The principles of nasal reconstruction center on application of the nasal subunit principle, three-layered reconstruction, nasal skin characteristics, and patient factors. Reconstructive planning starts with proper defect analysis, followed by application of the reconstructive ladder for soft-tissue repair, adequate structural support, and repair of nasal lining deficits...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226365/nasal-anatomy-and-function
#16
Ruchin G Patel
The nose is a complex structure important in facial aesthetics and in respiratory physiology. Nasal defects can pose a challenge to reconstructive surgeons who must re-create nasal symmetry while maintaining nasal function. A basic understanding of the underlying nasal anatomy is thus necessary for successful nasal reconstruction.
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28225496/impact-of-nasal-symptoms-on-the-evaluation-of-asthma-control
#17
Chien-Chia Huang, Po-Hung Chang, Pei-Wen Wu, Chun-Hua Wang, Chia-Hsiang Fu, Chi-Che Huang, Hsiao-Jung Tseng, Ta-Jen Lee
The united airways concept suggests that patients with asthma typically exhibit parallel inflammation in the upper airway. The resulting nasal symptoms should reduce quality of life and substantially affect the evaluation of asthma control among these patients. This study aimed to assess the association of nasal symptoms with the evaluation of asthma control.Fifty-eight patients with asthma and persistent nasal symptoms were prospectively recruited for evaluations of their sinonasal symptoms and asthma control in a cross-sectional study from August 2013 to June 2016...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28225490/clinical-characteristics-and-outcome-of-spanish-patients-with-anca-associated-vasculitides-impact-of-the-vasculitis-type-anca-specificity-and-treatment-on-mortality-and-morbidity
#18
Roser Solans-Laqué, Guadalupe Fraile, Monica Rodriguez-Carballeira, Luis Caminal, Maria J Castillo, Ferran Martínez-Valle, Luis Sáez, Juan J Rios, Xavier Solanich, Joaquim Oristrell, Francisco Pasquau, Eva Fonseca, Monica Zamora, Jose L Callejas, Begoña Frutos, Monica Abdilla, Patricia Fanlo, Isabel García-Sánchez, Miguel López-Dupla, Bernardo Sopeña, Almudena Pérez-Iglesias, Josep A Bosch
The aim of this study was to describe the clinical characteristics of ANCA-associated vasculitides (AAV) at presentation, in a wide cohort of Spanish patients, and to analyze the impact of the vasculitis type, ANCA specificity, prognostic factors, and treatments administered at diagnosis, in the outcome.A total of 450 patients diagnosed between January 1990 and January 2014 in 20 Hospitals from Spain were included. Altogether, 40.9% had granulomatosis with polyangiitis (GPA), 37.1% microscopic polyangiitis (MPA), and 22% eosinophilic granulomatosis with polyangiitis (EGPA)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28224628/quality-of-life-of-patients-who-underwent-aesthetic-rhinoplasty-100-cases-assessed-with-the-glascow-benefit-inventory
#19
Dimitrios Kotzampasakis, Anastasia Piniara, Sotirios Themelis, Stylianos Kotzampasakis, Eustratios Gabriel, Nikos Maroudias, Thomas Nikolopoulos
OBJECTIVES/HYPOTHESIS: The aim of the present study is to assess the long-term effect of classic rhinoplasty on patients' quality of life. STUDY DESIGN: Outcomes research. METHODS: The study included 100 operated patients; there were 34 males and 66 females. The ages ranged between 23 and 57 years old, with a mean of 36.4 years. A minimum of 3 years between the operation and the study was selected to assess the long-term effect of the operation on the patients' quality of life and exclude any short-term impressions...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28224626/intranasal-trigeminal-function-in-patients-with-empty-nose-syndrome
#20
Iordanis Konstantinidis, Evangelia Tsakiropoulou, Angelos Chatziavramidis, Christos Ikonomidis, Konstantinos Markou
OBJECTIVES/HYPOTHESIS: Trigeminal nerve mediates the perception of nasal airflow. This study examines whether impaired intranasal trigeminal function is a part of the paradoxical nasal obstruction sensation in patients with empty nose syndrome (ENS). STUDY DESIGN: Prospective case-control study in a tertiary hospital. METHODS: Three groups were examined: 1) ENS patients with previous bilateral near total inferior turbinectomy, 2) patients who underwent near total inferior turbinate removal (ITR) without ENS symptoms, and 3) control participants...
February 22, 2017: Laryngoscope
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