Xiao-Lu Ma, Yan-Yan Nie, Su-Hong Xie, Hui Zheng, Ying Tong, Yan-Chun Wang, Tian-Qing Yan, Xin Meng, Jia-Zhen Cao, Wei-Guo Tang, Lin Guo, Ren-Quan Lu
BACKGROUND: Sustained activation of hepatocyte growth factor (HGF)/c-MET signaling is a major driver of hepatocellular carcinoma (HCC) progression, but underlying mechanism is unclear. ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 2 (ASAP2) can reportedly activate GTPases and promote receptor tyrosine kinase signaling. However, the exact role of ASAP2 in HCC, especially for c-MET activation, also remains elusive. METHODS: ASAP2 expression levels in HCC tissues and cells were quantified using qRT-PCR, western blot (WB) analysis, and immunohistochemistry staining...
April 15, 2023: Experimental Hematology & Oncology