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https://www.readbyqxmd.com/read/29243789/relationship-between-blood-pressure-variability-and-target-organ-damage-in-elderly-patients
#1
C-L Li, R Liu, J-R Wang, J Yang
OBJECTIVE: To investigate the relationship between 24 h systolic blood pressure variability (SBPV) and target organ damage in elderly patients with essential hypertension. PATIENTS AND METHODS: 180 elderly patients (≥ 80 y) with hypertension admitted to our hospital from January 2015 to January 2017 were selected as hypertension group and divided into high blood pressure variability (BPV) group and low BPV group according to the 50th percentile (P50) of 24 h SBPV, while 90 elderly non-hypertension patients admitted during the same period were enrolled as control group...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29237836/structure-of-the-paramyxovirus-piv5-nucleoprotein-in-complex-with-an-amino-terminal-peptide-of-the-phosphoprotein
#2
Megha Aggarwal, George P Leser, Christopher A Kors, Robert A Lamb
Parainfluenza virus 5 (PIV5) belongs to the family Paramyxoviridae, which consists of enveloped viruses with a non-segmented negative strand RNA genome encapsidated by the nucleoprotein (N). Paramyxovirus replication is regulated by the phosphoprotein (P) through protein-protein interactions with N and the RNA polymerase (L). The chaperone activity of P is essential to maintain the unassembled RNA-free form of N in order to prevent non-specific RNA binding and premature N oligomerization. Here, we determined the crystal structure of unassembled PIV5 N in complex with a P peptide (N0P) derived from the N-terminus of P (P50) at 2...
December 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29232002/effects-of-microrna-93-on-mouse-cardiac-microvascular-endothelial-cells-injury-and-inflammatory-response-by-mediating-spp1-through-the-nf-%C3%AE-b-pathway
#3
Su-Xia Ma, Zhi-Feng Bai, Wei Wang, Hui-Ying Wu
BACKGROUND: This study aims to investigate the regulative role of microRNA-93 (miR-93) in mouse cardiac microvascular endothelial cells (CMECs) injury and inflammatory response by negatively targeting SPP1 gene via the NF-κB signaling pathway. METHODS: Healthy Balb/c mice were recruited to establish mouse model with myocarditis using CVB3 virus. Mice were grouped into the normal, blank, negative control (NC), miR-93 inhibitor, miR-93 mimic, SPP1 shRNA and miR-93 mimic + SPP1 shRNA groups...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29229533/xanthoceraside-attenuates-amyloid-%C3%AE-peptide1-42-induced-memory-impairments-by-reducing-neuroinflammatory-responses-in-mice
#4
Yue Qi, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Ge Jin, Qian Xu, Qing Jiao, Li-Hua Wang, Li-Bo Zou
Xanthoceraside, a novel triterpenoid saponin extracted from the husks of Xanthoceras sorbifolia Bunge, has neuroprotective effects in vivo and anti-inflammatory properties in vitro. However, the exact mechanism of xanthoceraside on anti-amyloid beta (Aβ)-induced neuroinflammatory responses has not been elucidated. Therefore, we used intracerebroventricular injection of amyloid 1-42 (Aβ1-42) to establish a mouse model to test the effects of xanthoceraside on Aβ-induced cognitive impairments and the TLR2/NF-κB and MAPK pathways...
December 8, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29225515/anticancer-activity-of-astragalus-polysaccharide-in-human-non-small-cell-lung-cancer-cells
#5
Chao-Yan Wu, Yuan Ke, Yi-Fei Zeng, Ying-Wen Zhang, Hai-Jun Yu
Background: We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-κB) activity during the development of diabetic nephropathy in mice. NF-κB plays important roles in genesis, growth, development and metastasis of cancer. NF-κB is also involved in the development of treatment resistance in tumors. Here we investigated the antitumor activity of APS in human non-small cell lung cells (A549 and NCI-H358) and the related mechanisms of action...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29212573/knockdown-of-nf-%C3%AE%C2%BAb1-by-shrna-inhibits-the-growth-of-renal-cell-carcinoma-in-vitro-and-in-vivo
#6
Amanda Ikegami, Luiz Felipe S Teixeira, Marina S Braga, Matheus Henrique Dos S Dias, Eduardo C Lopes, Maria Helena Bellini
Renal cell carcinoma (RCC) accounts for approximately 2-3% of human malignancies and is the most aggressive among urologic tumors. Biological heterogeneity, drug resistance and chemotherapy side effects are the biggest obstacles to the effective treatment of RCC. The NF-кB transcription factor is one of several molecules identified to be responsible for the aggressive phenotype of this tumor. In the past decade, several studies have demonstrated the activation of NF-kB in RCC, and many implicated NF-κB1 (p50) as an important molecule in tumor progression and metastasis...
December 1, 2017: Oncology Research
https://www.readbyqxmd.com/read/29206300/effects-of-mtor-nf-%C3%AE%C2%BAb-signaling-pathway-and-high-thoracic-epidural-anesthesia-on-myocardial-ischemia-reperfusion-injury-via-autophagy-in-rats
#7
Wei-Qiang Huang, Jian-Lin Wen, Ri-Qi Lin, Peng Wei, Feng Huang
We investigated the role of mammalian target of rapamycin/nuclear factor-kappa B (mTOR/NF-κB) signaling pathway in high thoracic epidural anesthesia (HTEA) against myocardial ischemia-reperfusion (I/R) injury in rats. The rat model of myocardial I/R injury was established. Ninety rats were divided into the normal, sham, I/R, eHTEA, the PDTC and HTEA + PDTC groups. ELISA was applied to detect cardiac function indexes. HE staining was conducted to observe histopathological changes of myocardial tissues, and TTC staining was performed to detect the myocardial infarction size...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29202656/clinical-and-cognitive-significance-of-auditory-sensory-processing-deficits-in-schizophrenia
#8
Holly K Hamilton, Terrance J Williams, Joseph Ventura, Leland J Jasperse, Emily M Owens, Gregory A Miller, Kenneth L Subotnik, Keith H Nuechterlein, Cindy M Yee
OBJECTIVE: Although patients with schizophrenia exhibit impaired suppression of the P50 event-related brain potential in response to the second of two identical auditory stimuli during a paired-stimulus paradigm, uncertainty remains over whether this deficit in inhibitory gating of auditory sensory processes has relevance for patients' clinical symptoms or cognitive performance. The authors examined associations between P50 suppression deficits and several core features of schizophrenia to address this gap...
December 5, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29199120/understanding-the-molecular-basis-of-the-high-oxygen-affinity-variant-human-hemoglobin-coimbra
#9
S E Jorge, M Bringas, A A Petruk, M Arrar, M A Marti, M S Skaf, F F Costa, L Capece, M F Sonati, D Estrin
Human hemoglobin (Hb) Coimbra (βAsp99Glu) is one of the seven βAsp99 Hb variants described to date. All βAsp99 substitutions result in increased affinity for O2 and decreased heme-heme cooperativity and their carriers are clinically characterized by erythrocytocis, caused by tissue hypoxia. Since βAsp99 plays an important role in the allosteric α1β2 interface and the mutation in Hb Coimbra only represents the insertion of a CH2 group in this interface, the present study of Hb Coimbra is important for a better understanding of the global impact of small modifications in this allosteric interface...
November 30, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29196978/the-role-of-soluble-epoxide-hydrolase-enzyme-on-daunorubicin-mediated-cardiotoxicity
#10
Zaid H Maayah, Ghada Abdelhamid, Osama H Elshenawy, Ahmed A El-Sherbeni, Hassan N Althurwi, Erica McGinn, Doaa Dawood, Ahmad H Alammari, Ayman O S El-Kadi
Several studies have demonstrated the role of cytochrome P450 (CYP) and its associated arachidonic acid (AA) metabolites in the anthracyclines-induced cardiac toxicity. However, the ability of daunorubicin (DNR) to induce cardiotoxicity through the modulation of CYP and its associated AA metabolites has not been investigated yet. Therefore, we hypothesized that DNR-induced cardiotoxicity is mediated through the induction of cardiotoxic hydroxyeicosatetraenoic acids and/or the inhibition of cardioprotctive epoxyeicosatrienoic acids (EETs)...
December 1, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29192407/de-novo-lipogenesis-and-desaturation-of-fatty-acids-during-adipogenesis-in-bovine-adipose-derived-mesenchymal-stem-cells
#11
Yongli Yue, Lichun Zhang, Xiang Zhang, Xueling Li, Haiquan Yu
Adipose-derived mesenchymal stem cells (ADSCs) are useful cell model to study adipogenesis and energy metabolism. However, the biological characteristics of bovine ADSCs (bADSCs) remain unclear. This study aimed to isolate and identify bADSCs and further investigate fatty acid (FA)-related gene expression and composition of FAs during adipogenesis. The growth curve showed the bADSCs of P5 cells had rapid proliferation superior to P10-P50. The colony formation assay showed colony number of P5 cells was higher than that of P50 cells (51...
November 30, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29191918/pml-nuclear-body-disruption-cooperates-in-apl-pathogenesis-and-impairs-dna-damage-repair-pathways-in-mice
#12
Edwige Voisset, Eva Moravcsik, Eva W Stratford, Amie Jaye, Christopher J Palgrave, Robert K Hills, Paolo Salomoni, Scott C Kogan, Ellen Solomon, David Grimwade
A hallmark of acute promyelocytic leukemia (APL) is altered nuclear architecture, with disruption of PML nuclear bodies (NBs) mediated by the PML-RARα oncoprotein. To address whether this phenomenon plays a role in disease pathogenesis, we generated a knock-in mouse model with NB disruption mediated by two point mutations (C62A/C65A) in the Pml RING domain. While no leukemias developed in PmlC62A/C65A mice, these transgenic mice also expressing RARα linked to a dimerization domain (p50-RARα model) exhibited a doubling in the rate of leukemia, with a reduced latency period...
November 30, 2017: Blood
https://www.readbyqxmd.com/read/29189196/iron-zinc-vitamin-a-and-selenium-status-in-a-cohort-of-indonesian-infants-after-adjusting-for-inflammation-using-several-different-approaches
#13
Aly Diana, Jillian J Haszard, Dwi M Purnamasari, Ikrimah Nurulazmi, Dimas E Luftimas, Sofa Rahmania, Gaga I Nugraha, Juergen Erhardt, Rosalind S Gibson, Lisa Houghton
Inflammation confounds the interpretation of several micronutrient biomarkers resulting in estimates that may not reflect the true burden of deficiency. We aimed to assess and compare the micronutrient status of a cohort of Indonesian infants (n 230) at aged 6, 9 and 12 months by ignoring inflammation (unadjusted) and adjusting four micronutrient biomarkers for inflammation with C-reactive protein (CRP) and α-1-glycoprotein (AGP) using the following methods: (1) arithmetic correction factors with the use of a four-stage inflammation model; and (2) regression modelling...
November 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29188404/enhanced-igg1-production-by-overexpression-of-nuclear-factor-kappa-b-inhibitor-zeta-nfkbiz-in-chinese-hamster-ovary-cells
#14
Masayoshi Onitsuka, Yukie Kinoshita, Akitoshi Nishizawa, Tomomi Tsutsui, Takeshi Omasa
Several engineering strategies have been employed to improve the production of therapeutic recombinant proteins in Chinese hamster ovary (CHO) cell lines. We have focused on unfolded protein response-based engineering and reported that ATF4 overexpression increases protein production. In this study, transcriptome analysis of ATF4-overexpressed CHO cells was performed using high-coverage expression profiling, to search for another key factor contributing to recombinant protein production. We observed the upregulated expression of transcription factor, nuclear factor (NF)-kappa-B inhibitor zeta (NFKBIZ or Iκbζ), in ATF4-overexpressed cells...
November 29, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29186964/yeast-two-hybrid-and-pull-down-assays-propose-an-interaction-between-p50-of-apple-chlorotic-leaf-spot-virus-and-pr-10-of-malus-sylvestris-cv-r12740-7a
#15
Y Wang, N Li, X Zhao, J Hu, Y He, T Hu, S Wang, Y Wang, K Cao
Apple chlorotic leaf spot virus (ACLSV) movement protein (P50) is involved in cell-to-cell transport and influences the long-distance spread of silencing activity. Previously, we obtained 69 P50-interacting proteins from Malus sylvestris cv. R12740-7A and using bioinformatics analyzed their biological functions. In this study, we used the GAL4-based two-hybrid yeast system and His pull-down assays to confirm an interaction between PR-10 of M. sylvestris cv. R12740-7A and ACLSV P50. Our results provide a theoretical basis for further research on the biological function of PR-10 in ACLSV infection and the interacting mechanism between host and virus...
2017: Acta Virologica
https://www.readbyqxmd.com/read/29182579/antarctic-krill-oil-diet-protects-against-lipopolysaccharide-induced-oxidative-stress-neuroinflammation-and-cognitive-impairment
#16
Ji Yeon Choi, Jun Sung Jang, Dong Ju Son, Hyung-Sik Im, Ji Yeong Kim, Joung Eun Park, Won Rak Choi, Sang-Bae Han, Jin Tae Hong
Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer's disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We examined whether krill oil diet (80 mg/kg/day for one month) prevents amyloidogenesis and cognitive impairment induced by intraperitoneal lipopolysaccharide (LPS) (250 µg/kg, seven times daily) injections in AD mice model and found that krill oil treatment inhibited the LPS-induced memory loss...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29179451/anti-cancer-effects-of-dopamine-in-human-glioma-involvement-of-mitochondrial-apoptotic-and-anti-inflammatory-pathways
#17
Yu-Long Lan, Xun Wang, Jin-Shan Xing, Zhen-Long Yu, Jia-Cheng Lou, Xiao-Chi Ma, Bo Zhang
Despite the emergence of innovative cancer treatment strategies, the global burden imposed by malignant glioma is expected to increase; thus, new approaches for treating the disease are urgently required. Dopamine, a monoamine catecholamine neurotransmitter, is currently regarded as an important endogenous regulator of tumor growth. Dopamine may play an important role in glioma treatment; however, the mechanism underlying the anti-tumor activity of dopamine remains poorly understood. Here, we explored the potential roles of dopamine in glioma and highlight the importance of endogenous regulators of tumor growth...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29177476/functional-relationships-between-wood-structure-and-vulnerability-to-xylem-cavitation-in-races-of-eucalyptus-globulus-differing-in-wood-density
#18
Antonio José Barotto, Silvia Monteoliva, Javier Gyenge, Alejandro Martinez-Meier, María Elena Fernandez
Wood density can be considered as a measure of the internal wood structure, and it is usually used as a proxy measure of other mechanical and functional traits. Eucalyptus is one of the most important commercial forestry genera worldwide, but the relationship between wood density and vulnerability to cavitation in this genus has been little studied. The analysis is hampered by, among other things, its anatomical complexity, so it becomes necessary to address more complex techniques and analyses to elucidate the way in which the different anatomical elements are functionally integrated...
November 21, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29176558/intraspecific-variation-and-plasticity-in-mitochondrial-oxygen-binding-affinity-as-a-response-to-environmental-temperature
#19
Dillon J Chung, P R Morrison, H J Bryant, E Jung, C J Brauner, P M Schulte
Mitochondrial function has been suggested to underlie constraints on whole-organism aerobic performance and associated hypoxia and thermal tolerance limits, but most studies have focused on measures of maximum mitochondrial capacity. Here we investigated whether variation in mitochondrial oxygen kinetics could contribute to local adaptation and plasticity in response to temperature using two subspecies of the Atlantic killifish (Fundulus heteroclitus) acclimated to a range of temperatures (5, 15, and 33 °C)...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29174381/anti-neuroinflammatory-effect-of-6-8-1-tri-o-methylaverantin-a-metabolite-from-a-marine-derived-fungal-strain-aspergillus-sp-via-upregulation-of-heme-oxygenase-1-in-lipopolysaccharide-activated-microglia
#20
Kwan-Woo Kim, Hye Jin Kim, Jae Hak Sohn, Joung Han Yim, Youn-Chul Kim, Hyuncheol Oh
In the course of searching for anti-neuroinflammatory metabolites from marine-derived fungi, three fungal metabolites, 6,8,1'-tri-O-methylaverantin, 6,8-di-O-methylaverufin, and 5-methoxysterigmatocystin were isolated from a marine-derived fungal strain Aspergillus sp. SF-6796. Among these, 6,8,1'-tri-O-methylaverantin induced the expression of heme oxygenase (HO)-1 protein in BV2 microglial cells. The induction of HO-1 protein was mediated by the activation of nuclear transcription factor erythroid-2 related factor 2 (Nrf2), and was regulated by the p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase/protein kinase B signaling pathways...
November 21, 2017: Neurochemistry International
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