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https://www.readbyqxmd.com/read/27933352/intracochlear-drug-delivery-in%C3%A2-combination-with-cochlear-implants-current-aspects
#1
S K Plontke, G Götze, T Rahne, A Liebau
Local drug application to the inner ear offers a number of advantages over systemic delivery. Local drug therapy currently encompasses extracochlear administration (i. e., through intratympanic injection), intracochlear administration (particularly for gene and stem cell therapy), as well as various combinations with auditory neurosensory prostheses, either evaluated in preclinical or clinical studies, or off-label. To improve rehabilitation with cochlear implants (CI), one focus is the development of drug-releasing electrode carriers, e...
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27933350/endoscopic-ear-surgery%C3%A2-a%C3%A2-complement-to-microscopic-ear-surgery
#2
S Preyer
Wullstein, the founder of modern microscopic ear surgery, already used an oto-endoscope intraoperatively. However, it is only after the recent development of modern video-endoscopy with high-definition, 4K, and 3‑dimensional imaging that endoscopically guided surgery of the middle ear is gaining some importance. Key ventilation routes like the isthmus tympani and the epitympanic diaphragm can be visualized far better using an endoscope than with a microscope. Going through the external meatus, surgery of middle ear pathologies is possible without external incision...
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27932858/one-stage-bone-strip-reconstruction-technique-with-balloon-sinus-dilatation-surgery-for-chronic-maxillary-atelectasis
#3
Tomoyuki Kashima, Robert A Goldberg, Jocelyne C Kohn, Daniel B Rootman
PURPOSE: Chronic maxillary atelectasis is characterized by unilateral spontaneous enophthalmos and hypoglobus due to increased orbital volume secondary to maxillary sinus inward deformation. Reformation of the sinus architecture and reconstruction of the orbit are key to a successful outcome. Here, we introduce a one-staged surgery that addresses both these goals. PATIENTS AND METHODS: We retrospectively reviewed 11 patients treated with one-stage orbital and sinus surgery...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27932750/-a-case-report-of-spontaneous-cerebrospinal-fluid-otorrhea
#4
Hidenori Anami, Shigeru Ikeda, Kotaro Nakaya, Makoto Sugiura, Takakazu Kawamata
Spontaneous cerebrospinal fluid(CSF)otorrhea is less common than CSF leakage caused by trauma, and rarely occurs in adults. We report an adult case of CSF otorrhea. A 71-year-old woman with no traumatic or otologic history was hospitalized due to bacterial meningitis. After hospitalization, CSF leakage started suddenly from the left external ear canal. A high resolution CT scan with intrathecal administration of contrast material revealed CSF leakage in the left ear canal and multiple bone erosions in both the tegmen mastoideum and the posterior fossa aspect of the petrous bone...
December 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27932517/allergin-1-inhibits-tlr2-mediated-mast-cell-activation-and-suppresses-dermatitis
#5
Satoshi Tsurusaki, Satoko Tahara-Hanaoka, Shohei Shibagaki, Shota Miyake, Masamichi Imai, Shiro Shibayama, Masato Kubo, Akira Shibuya
TLR2 recognizes cell wall components of Staphylococcus aureus, which colonizes >90% of atopic eczematous skin lesions. The regulatory mechanisms of TLR2 signaling in the skin remain unclear. Allergin-1, an inhibitory immunoglobulin-like receptor containing an ITIM, is expressed on mast cells (MCs) and inhibits IgE-mediated anaphylaxis in mice. Here, we show that Allergin-1 inhibits TLR2-mediated activation of, and inflammatory cytokine production by, MCs in vitro Compared with wild-type mice, Allergin-1-deficient mice showed enhanced ear swelling with enhanced collagen deposition and greater Ly6G(+) neutrophil recruitment after intra-dermal injection of Pam2CSK4 into pinnae...
November 8, 2016: International Immunology
https://www.readbyqxmd.com/read/27932389/fifteen-minute-consultation-investigation-and-management-of-an-infant-with-stridor
#6
E Hoskison, J Grainger
Stridor is an abnormal sound caused by turbulent airflow through the airway. In an infant under 3 months of age presenting with stridor, there are many different underlying aetiologies. Some key assessment points help to differentiate those patients who can be reassured and monitored versus those requiring referral to an ear, nose and throat (ENT) surgeon for further assessment or management. We present a structured approach to guide the clinician through initial assessment, examination and management, including referral to ENT surgery...
December 8, 2016: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/27931699/recovery-after-same-day-surgery-in-patients-receiving-general-anesthesia-a-cohort-study-using-the-quality-of-recovery-40-questionnaire
#7
Herdis Sveinsdottir, Thordis Borgthorsdottir, Maria Titia Asgeirsdottir, Kolbrun Albertsdottir, Lara Borg Asmundsdottir
BACKGROUND: The contemporary rise in the number of elective procedures performed in same-day surgery (SDS) requires that health care professionals increase their knowledge of patient satisfaction and recovery, including patient-assessed quality of life. This study investigates the quality of recovery (QoR) of anesthetized SDS patients. METHODS: Data from SDS patients were collected from hospital records at T1 (the morning before operation), T2 (day 1 postsurgery), and T3 (day 4 postsurgery)...
December 2016: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/27931523/a-blue-middle-ear-mass-cholesterol-granuloma-mimicking-a-glomus-tumor-and-endolymphatic-sac-tumor
#8
Clara Olcott, Barry Strasnick
Cholesterol granuloma (CG) is the most common benign lesion of the petrous apex, however, it can grow significantly large and become destructive causing a diagnostic dilemma. This case presents a 25-year-old female with 2-year history of left-sided progressive and profound hearing loss, a transient left-sided facial paralysis and cranial nerve 10 palsy who presented with a blue middle ear mass. Her diagnosis did not become apparent until direct visualization intraoperatively. The objective of this case study is to highlight the destructive capabilities of CG and the importance to keep it in the differential diagnosis of a large, erosive, expansile skull base lesion in order to avoid overly aggressive resection or other unnecessary treatment...
January 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27931024/acoustic-characteristics-of-long-calls-produced-by-male-orang-utans-pongo-pygmaeus-wurmbii-advertising-individual-identity-context-and-travel-direction
#9
James A Askew, Helen C Morrogh-Bernard
Acoustic characteristics and context of the long-distance call of male orang-utans (Pongo pygmaeus wurmbii) were examined in a population of orang-utans from Central Kalimantan, Borneo. Male orang-utans produced long calls under different circumstances, including calls made spontaneously, in response to conspecifics, when accompanied by a snag crash and when travelling with a female. It was shown by acoustic analyses that there was individual discrimination between the male's calls, discrimination between the calls made under different contexts, and between calls from one individual from different years, which coincided with a change in his dominance status...
December 9, 2016: Folia Primatologica; International Journal of Primatology
https://www.readbyqxmd.com/read/27930688/a-time-to-wean-impact-of-weaning-age-on-anxiety-like-behaviour-and-stability-of-behavioural-traits-in-full-adulthood
#10
S Helene Richter, Niklas Kästner, Dirk-Heinz Loddenkemper, Sylvia Kaiser, Norbert Sachser
In mammals, weaning constitutes an important phase in the progression to adulthood. It comprises the termination of suckling and is characterized by several changes in the behaviour of both mother and offspring. Furthermore, numerous studies in rodents have shown that the time point of weaning shapes the behavioural profile of the young. Most of these studies, however, have focused on 'early weaning', while relatively little work has been done to study 'late weaning' effects. The aim of the present study was therefore to explore behavioural effects of 'late weaning', and furthermore to gain insights into modulating effects of weaning age on the consistency of behavioural expressions over time...
2016: PloS One
https://www.readbyqxmd.com/read/27930657/the-effects-of-auricular-electro-acupuncture-on-ameliorating-the-dysfunction-of-interstitial-cells-of-cajal-networks-and-nnosmrna-expression-in-antrum-of-stz-induced-diabetic-rats
#11
Huan Chen, Weijian Zhu, Jing Lu, Jinqing Fan, Luning Sun, Xiaoke Feng, Hao Liu, Zhaohui Zhang, Yongqing Wang
BACKGROUD: Interstitial cells of Cajal (ICCs) and nNOS play a crucial role in diabetic gastrointestinal dysmotility(DGD). Our previous study found that electro-acupuncture(EA) on ear point 'stomach' could repair the gastric dysrhythmias in rats induced by rectal distention(RD) after meal. However, little were known about the possible effect of auricular electro-acupuncture (AEA) on diabetic rats. Thus, we designed this study to investigate the effect of AEA on streptozotocin(STZ)-induced diabetic rats...
2016: PloS One
https://www.readbyqxmd.com/read/27930470/correction-of-lying-ears-by-augmentation-of-the-conchoscaphal-angle
#12
Sung-Eun Kim, Chi-Ho Yeo, Taegon Kim, Yong-Ha Kim, Jun Ho Lee, Kyu-Jin Chung
Lying ears are defined as ears that protrude less from the head, and in frontal view, are characterized by lateral positioning of antihelical contour relative to the helical rim. These aesthetically displeasing ears require correction in accord with the goals of otoplasty stated by McDowell. The authors present a case of lying ears treated by correcting the conchomastoid angle using Z-plasty, resection of posterior auricular muscle, and correction of the conchoscaphal angle by releasing cartilage using 2 full-thickness incisions and grafting of a conchal cartilage spacer...
December 7, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27930375/comparison-of-intra-arterial-and-subcutaneous-testicular-hyaluronidase-injection-treatments-and-the-vascular-complications-of-hyaluronic-acid-filler
#13
Muyao Wang, Wei Li, Yan Zhang, Weidong Tian, Hang Wang
BACKGROUND: Hyaluronidase is a key preventative treatment against vascular complications of hyaluronic acid (HA) filler injection, but the degradation profile of HA to hyaluronidase is limited, and the comparison between intra-arterial and subcutaneous injections of hyaluronidase has not been studied. OBJECTIVE: To evaluate HA degradation to hyaluronidase and compare different treatments between intra-arterial and subcutaneous testicular hyaluronidase injections...
December 2, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27928634/pressurized-wideband-acoustic-stapedial-reflex-thresholds-normal-development-and-relationships-to-auditory-function-in-infants
#14
Lisa L Hunter, Douglas H Keefe, M Patrick Feeney, Denis F Fitzpatrick
This study analyzed effects of pressurization on wideband acoustic stapedial-muscle reflex (ASR) tests in infants cared for in normal newborn (NN) and neonatal intensive care units (NICU). Effects of hearing-screening outcomes on ASR threshold measurements were also evaluated, and a subsequent longitudinal study established normative threshold ranges over the first year after birth. An initial experiment compared thresholds in newborns measured at ambient pressure in the ear canal and at the tympanometric peak pressure...
December 7, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27928451/bilateral-external-ear-canal-osteomas-discussion-on-a-clinical-case
#15
Gheorghe Dc, Stanciu Ae, Ulici A, Zamfir-Chiru-Anton A
Osteomas of the external ear are uncommon benign tumors that need to be differentiated from the external ear canal exostoses, bony proliferations that are linked mainly to cold-water exposure. Clinical manifestations vary from no symptoms to recurrent local infections and external ear cholesteatoma. Objective: presenting a rare case that we did not find described in the published literature. A patient with multiple long-term asymptomatic osteomas of both external ear canals presented to our department. Material: Data recorded from the patient's medical record was reviewed and analyzed...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27927982/evidence-for-a-right-ear-advantage-in-newborn-hearing-screening-results
#16
Daphne Ari-Even Roth, Minka Hildesheimer, Ilan Roziner, Yael Henkin
The aim of the present study was to investigate the effect of ear asymmetry, order of testing, and gender on transient-evoked otoacoustic emission (TEOAE) pass rates and response levels in newborn hearing screening. The screening results of 879 newborns, of whom 387 (study group) passed screening successfully in only one ear in the first TEOAE screening, but passed screening successfully in both ears thereafter, and 492 (control group) who passed screening successfully in both ears in the first TEOAE, were retrospectively examined for pass rates and TEOAE characteristics...
December 6, 2016: Trends in Hearing
https://www.readbyqxmd.com/read/27926945/ear-structures-of-the-naked-mole-rat-heterocephalus-glaber-and-its-relatives-rodentia-bathyergidae
#17
Matthew J Mason, Hannah L Cornwall, Ewan St J Smith
Although increasingly popular as a laboratory species, very little is known about the peripheral auditory system of the naked mole-rat, Heterocephalus glaber. In this study, middle and inner ears of naked mole-rats of a range of ages were examined using micro-computed tomography and dissection. The ears of five other bathyergid species (Bathyergus suillus, Cryptomys hottentotus, Fukomys micklemi, Georychus capensis and Heliophobius argenteocinereus) were examined for comparative purposes. The middle ears of bathyergids show features commonly found in other members of the Ctenohystrica rodent clade, including a fused malleus and incus, a synovial stapedio-vestibular articulation and the loss of the stapedius muscle...
2016: PloS One
https://www.readbyqxmd.com/read/27926851/energy-output-from-a-single-outer-hair-cell
#18
Kuni H Iwasa
Electromotility of outer hair cells (OHCs) has been extensively studied with in vitro experiments because of its physiological significance to the cochlear amplifier, which provides the exquisite sensitivity and frequency selectivity of the mammalian ear. However, these studies have been performed largely under load-free conditions or with static load, while these cells function in vivo in a dynamic environment, receiving electrical energy to enhance mechanical oscillation in the inner ear. This gap leaves uncertainties in addressing a key issue, how much mechanical energy an OHC provides...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27925669/biochemical-biophysical-and-cellular-techniques-to-study-the-guanine-nucleotide-exchange-factor-giv-girdin
#19
Pradipta Ghosh, Nicolas Aznar, Lee Swanson, I-Chung Lo, Inmaculada Lopez-Sanchez, Jason Ear, Cristina Rohena, Nicholas Kalogriopoulos, Linda Joosen, Ying Dunkel, Nina Sun, Peter Nguyen, Deepali Bhandari
Canonical signal transduction via heterotrimeric G proteins is spatiotemporally restricted, i.e., triggered exclusively at the plasma membrane, only by agonist activation of G protein-coupled receptors via a finite process that is terminated within a few hundred milliseconds. Recently, a rapidly emerging paradigm has revealed a noncanonical pathway for activation of heterotrimeric G proteins via the nonreceptor guanidine-nucleotide exchange factor, GIV/Girdin. Biochemical, biophysical, and functional studies evaluating this pathway have unraveled its unique properties and distinctive spatiotemporal features...
December 7, 2016: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/27925221/pharmacokinetic-pharmacodynamic-evaluation-of-grapiprant-in-a-carrageenan-induced-inflammatory-pain-model-in-the-rabbit
#20
V De Vito, M Salvadori, A Poapolathep, H Owen, R Rychshanova, M Giorgi
Grapiprant is the novel selective EP4 receptor inhibitor recently issued on the veterinary market for dogs affected by osteoarthritis. The aim of this study was twofold: to evaluate the pharmacokinetics and the pharmacodynamics of grapiprant in the induced inflammatory pain model in the rabbit after a single IV injection of 2 mg/kg; to compare the thermal antinociception effect after 2 mg/kg IV grapiprant, with that generated by 0.5 mg/kg meloxicam SC injected. Rabbits (n = 12) were randomly assigned to two crossover studies (single-dose, two-period crossover)...
December 7, 2016: Journal of Veterinary Pharmacology and Therapeutics
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