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https://www.readbyqxmd.com/read/29775023/-the-role-of-th1-th2-cells-imbalance-in-the-pathogenesis-of-secretory-otitis-media
#1
Z H Li, Q Y Fu, Z Y Li, K X Wang, Y C Xu, J P Xue
Objective: The aim of this study is to explore the role of Th1/Th2 cells imbalance in the pathogenesis of secretory otitis media. Method: Ninety secretory otitis media patients were enrolled in observation group. According to medical history, they were divided into acute and chronic group. In addition, 90 healthy volunteers during the same period were selected as the control group. The levels of Th1-type cytokines IFN-γ, Th2-type cytokines interleukin-4 (IL-4) and IFN-γ/IL-4 in peripheral blood were compared between observation group and control group...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775021/-the-correlation-between-radiological-classification-and-clinical-audiometry-in-otosclerosis
#2
Y Ren, K Wang, J Q Zhang
Objective: The aim of this study is to explore the correlation between radiological classification on HRCT and effects on surgery with hearing improvement in otosclerosis. Method: Thirty three patients (66 ears) with otosclerosis were enrolled to this study, who would be done operation using Fischs stapes surgery technique. All patients were classified according to axial HRCT preoperatively. All patients were evaluated by pure tone test preoperatively and 6 months postoperatively. Correlation between radiological classification and hearing effects were studied...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775000/-the-treatment-efficiency-of-a-new-ear-moding-device-in-the-infants-with-congenital-ear-abnormalities
#3
P W Chen, J Li, S Q Zhao, J S Yang, J M Dou, C Y Wei
Objective: To observe the nonsurgical treatment effciency of a new ear moding device on congenital auricle deformities in order to promote clinical application. Method: Twenty-nine patients (38 ears) from Beijing Tongren Hospital Outpatient received ear molding treatment using the EarWell Infant Ear Correction System. We keep regular follow-up and close observation during the moding period. The treatment effciency was judged by the otologist, plastic surgeons and parents based on the preprocedure and postprocedure photographs and divided into 3 grades: excellent, good and poor...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774994/-comparative-study-of-intratympanic-dexamethasone-injection-for-sudden-deafness-at-different-time-intervals
#4
P L Yang, Z P Zhang
Objective: Comparative study of intratympanic Dexamethasone injection for sudden deafness at different time intervals. Method: One hundred and sixty cases which had been diagnosed sudden deafness were treated by vasodilatortrophic nerve drugs and high pressure oxygen and the same time dexamethasone injective in the middle ear. Injection time intervals were divided into qd, qod, and twice a week. Contral group is not use dexamethasone. Result: The cure rate of qd and qod groups were higher than twice a week group, and the difference was statistically significant ( P <0...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774586/genome-wide-association-study-reveals-novel-genes-for-the-ear-size-in-sheep-ovis-aries
#5
L Gao, S-S Xu, J-Q Yang, M Shen, M-H Li
Variations in ear size can be observed in livestock such as sheep; however, the genetic basis of variable ear size in sheep is still poorly understood. To investigate causative genes associated with ear size in sheep, a genome-wide association study was performed in 115 adult Duolang sheep with different-sized floppy ears using the Ovine Infinium HD BeadChip. We found 38 significant SNPs at the genome-wide or chromosome-wise 5% significance level after Bonferroni correction. The most significant association (P = 1...
May 18, 2018: Animal Genetics
https://www.readbyqxmd.com/read/29774497/safety-of-commercial-airflight-in-patients-with-brain-tumors-a-case-series
#6
Michelle Phillips, Marlon Saria, Amy Eisenberg, Daniel F Kelly, Garni Barkhoudarian
INTRODUCTION: Patients with intracranial masses are often advised to avoid airflight due to concerns of worsening neurological symptoms or deterioration. However, many patients often travel cross-country or internationally to tertiary care centers for definitive care. This study assesses the safety of commercial airflight for brain and skull base tumor patients without severe or progressive neurological deficits. METHODS: Patients that had traveled to our institution for surgery via commercial airflight from 2014 to 2017 were identified...
May 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29774461/nonlinear-analysis-of-electrodermal-activity-signals-for-healthy-subjects-and-patients-with-chronic-obstructive-pulmonary-disease
#7
Serife Gokce Caliskan, Mehmet Dincer Bilgin, Mehmet Polatli
It is known that signals recorded from physiological systems represent nonlinear features. Several recent studies report that quantitative information about signal complexity is obtained by using nonlinear analysis algorithms. Chronic obstructive pulmonary disease (COPD) is one of the causes of mortality worldwide with an increasing prevalence. This study aims to investigate nonlinear parameters such as largest Lyapunov exponent (LLE) and correlation dimension of electrodermal activity signals recorded from healthy subjects and patients with COPD...
May 17, 2018: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29773841/ocular-counter-rolling-in-astronauts-after-short-and-long-duration-spaceflight
#8
Millard F Reschke, Scott J Wood, Gilles Clément
Ocular counter-rolling (OCR) is a reflex generated by the activation of the gravity sensors in the inner ear that stabilizes gaze and posture during head tilt. We compared the OCR measures that were obtained in 6 astronauts before, during, and after a spaceflight lasting 4-6 days with the OCR measures obtained from 6 astronauts before and after a spaceflight lasting 4-9 months. OCR in the short-duration fliers was measured using the afterimage method during head tilt at 15°, 30°, and 45°. OCR in the long-duration fliers was measured using video-oculography during whole body tilt at 25°...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773191/anti-inflammatory-and-antinociceptive-effects-of-2-2-dipyridyl-diselenide-through-reduction-of-inducible-nitric-oxide-synthase-nuclear-factor-kappa-b-and-c-jun-n-terminal-kinase-phosphorylation-levels-in-the-mouse-spinal-cord
#9
Suzan Gonçalves Rosa, César Augusto Brüning, Ana Paula Pesarico, Ana Cristina Guerra de Souza, Cristina Wayne Nogueira
Appropriate treatment of pain requires analgesics and anti-inflammatory drugs generally associated with undesirable side effects and not fully effective in a significant proportion of patients. Organoselenium compounds elicit a plenty of pharmacological effects in different animal models. Among these compounds, the 2,2`-dipyridyl diselenide (DPD) has a potent antioxidant effect and low toxicity. In this way, the aim of this study was to investigate the possible DPD antinociceptive effect and its mechanism of action, as well as the safety of the compound...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29772954/electric-acoustic-stimulation-suppresses-tinnitus-in-a-subject-with-high-frequency-single-sided-deafness
#10
Griet Mertens, Vincent Van Rompaey, Paul Van de Heyning
BACKGROUND: A suggested solution to suppress tinnitus is to restore the normal sensory input. This is based on the auditory deprivation hypothesis. It is known that hearing aids can provide sufficient activation of the auditory nervous system and reduce tinnitus in subjects with mild to moderate hearing loss and that cochlear implantation can reduce tinnitus in subjects with severe to profound hearing loss. This applies to subjects with single-sided deafness (SSD) or bilateral hearing loss...
May 17, 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29772756/developing-an-acoustic-sensing-yarn-for-health-surveillance-in-a-military-setting
#11
Theodore Hughes-Riley, Tilak Dias
Overexposure to high levels of noise can cause permanent hearing disorders, which have a significant adverse effect on the quality of life of those affected. Injury due to noise can affect people in a variety of careers including construction workers, factory workers, and members of the armed forces. By monitoring the noise exposure of workers, overexposure can be avoided and suitable protective equipment can be provided. This work focused on the creation of a noise dosimeter suitable for use by members of the armed forces, where a discrete dosimeter was integrated into a textile helmet cover...
May 17, 2018: Sensors
https://www.readbyqxmd.com/read/29771904/development-of-an-otitis-media-strategy-in-the-pacific-key-informant-perspectives
#12
Elizabeth Holt, Judith McCool, Vili Nosa, Peter Thorne
AIM: Ear and hearing health services are scarce within Pacific Island countries. Where available, they remain under-resourced, despite there being a high estimated prevalence of otitis media and otitis media-related hearing loss. This study examines the potential for improving ear and hearing health strategies by examining key factors, opportunities and challenges, working with Fiji as a case study. METHOD: A series of semi-structured interviews were conducted with professionals who had experience in otitis media programme implementation and/or professionals with working experience within the Pacific region and the Fiji health system...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29771872/outbreaks-associated-with-treated-recreational-water-united-states-2000-2014
#13
Michele C Hlavsa, Bryanna L Cikesh, Virginia A Roberts, Amy M Kahler, Marissa Vigar, Elizabeth D Hilborn, Timothy J Wade, Dawn M Roellig, Jennifer L Murphy, Lihua Xiao, Kirsten M Yates, Jasen M Kunz, Matthew J Arduino, Sujan C Reddy, Kathleen E Fullerton, Laura A Cooley, Michael J Beach, Vincent R Hill, Jonathan S Yoder
Outbreaks associated with exposure to treated recreational water can be caused by pathogens or chemicals in venues such as pools, hot tubs/spas, and interactive water play venues (i.e., water playgrounds). During 2000-2014, public health officials from 46 states and Puerto Rico reported 493 outbreaks associated with treated recreational water. These outbreaks resulted in at least 27,219 cases and eight deaths. Among the 363 outbreaks with a confirmed infectious etiology, 212 (58%) were caused by Cryptosporidium (which causes predominantly gastrointestinal illness), 57 (16%) by Legionella (which causes Legionnaires' disease, a severe pneumonia, and Pontiac fever, a milder illness with flu-like symptoms), and 47 (13%) by Pseudomonas (which causes folliculitis ["hot tub rash"] and otitis externa ["swimmers' ear"])...
May 18, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29771843/facial-paralysis-in-patients-with-hemifacial-microsomia-frequency-distribution-and-association-with-other-omens-abnormalities
#14
Qiang Li, Xu Zhou, Yue Wang, Jin Qian, Qingguo Zhang
Although facial paralysis is a fundamental feature of hemifacial microsomia, the frequency and distribution of nerve abnormalities in patients with hemifacial microsomia remain unclear. In this study, the authors classified 1125 cases with microtia (including 339 patients with hemifacial microsomia and 786 with isolated microtia) according to Orbital Distortion Mandibular Hypoplasia Ear Anomaly Nerve Involvement Soft Tissue Dependency (OMENS) scheme. Then, the authors performed an independent analysis to describe the distribution feature of nerve abnormalities and reveal the possible relationships between facial paralysis and the other 4 fundamental features in the OMENS system...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29771089/-an-analysis-of-electrocochleography-in-patients-with-osahs
#15
W T Sun, Y Chen, H H Lu, H Y Ruan, R M Liang, C Chen, J P Zhang
Objective: To investigate the values of electrocochleograph(ECochG)in patients with OSAHS. Method: ECochG was performed in 31 (62 ears) OSAHS patients (moderately 5 cases, severely 26 cases) and 28 healthy adults (56 ears). AP latency ,AP amplitude and SP/AP were measured and analyzed. Result: There was no difference between the two groups in SP/AP amplitude ratio( P >0.05) while both AP latency( P <0.05) and AP amplitude( P <0.05) were significantly different. Conclusion: ECochG can confirm the damage of cochlear and auditory nerve near the cochlear segment in patients with moderate to severe OSAHS...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770276/the-evaluation-of-anoxia-responsive-e2f-dna-binding-activity-in-the-red-eared-slider-turtle-trachemys-scripta-elegans
#16
Kyle K Biggar, Kenneth B Storey
In many cases, the DNA-binding activity of a transcription factor does not change, while its transcriptional activity is greatly influenced by the make-up of bound proteins. In this study, we assessed the protein composition and DNA-binding ability of the E2F transcription factor complex to provide insight into cell cycle control in an anoxia tolerant turtle through the use of a modified ELISA protocol. This modification also permits the use of custom DNA probes that are tailored to a specific DNA binding region, introducing the ability to design capture probes for non-model organisms...
2018: PeerJ
https://www.readbyqxmd.com/read/29770252/utility-of-magnetic-resonance-cisternography-with-intrathecal-gadolinium-in-detection-of-cerebrospinal-fluid-fistula-associated-with-mondini-dysplasia-in-a-patient-with-recurrent-meningitis-case-report-and-literature-review
#17
Enrique Caro-Osorio, Alba Espino-Ojeda, Lino Guevara-Maldonado, José C Herrea-Castro
Background: The intrathecal contrast-enhanced magnetic resonance cisternography (MRC) is a diagnostic method that has been proven effective in selected patients with various disorders of the cerebrospinal system, including the detection of cerebrospinal fluid (CSF) leaks. The Mondini dysplasia is a malformation of the inner ear characterized by an incomplete cochlear development. The cerebrospinal fistula associated with Mondini dysplasia usually occurs in the first 5-10 years. Case Description: The case of a 34-year-old woman with CSF rhinorrhea and recurrent meningitis associated with CSF fistula into the right inner ear, which was detected by MRC with intrathecal gadolinium, is presented...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29770082/first-reported-case-of-multidrug-resistant-candida-auris-in-canada
#18
I S Schwartz, G W Hammond
Candida auris is a fungal pathogen that has recently emerged as a global threat to public health. It was first described in Japan in 2009 and has since been reported in 17 countries on five continents. This case report describes the first reported case of multidrug-resistant C. auris in Canada. In May 2017, a 64-year-old individual was evaluated for chronic otitis externa. Past medical history included a recent hospitalization in India for elective oral surgery that was complicated by an odontogenic brain abscess...
July 6, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769366/mate-choice-in-the-eye-and-ear-of-the-beholder-female-multimodal-sensory-configuration-influences-her-preferences
#19
Kelly L Ronald, Esteban Fernández-Juricic, Jeffrey R Lucas
A common assumption in sexual selection studies is that receivers decode signal information similarly. However, receivers may vary in how they rank signallers if signal perception varies with an individual's sensory configuration. Furthermore, receivers may vary in their weighting of different elements of multimodal signals based on their sensory configuration. This could lead to complex levels of selection on signalling traits. We tested whether multimodal sensory configuration could affect preferences for multimodal signals...
May 16, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29769265/reciprocal-negative-regulation-between-lmx1a-and-lmo4-is-required-for-inner-ear-formation
#20
Yanhan Huang, Jennifer Hill, Andrew Yatteau, Loksum Wong, Tao Jiang, Jelena Petrovic, Lin Gan, Lijin Dong, Doris K Wu
LIM-domain containing transcription factors (LIM-TFs) are conserved factors important for embryogenesis. The specificity of these factors in transcriptional regulation is conferred by the complexes they form with other proteins such as LIM-domain-binding (Ldb) proteins and LIM-domain only (LMO) proteins. Unlike LIM-TF, these proteins do not bind DNA directly. LMO are negative regulators of LIM-TF and they function by competing with LIM-TFs for binding to Ldbs. Although the LIM-TF Lmx1a is expressed in the developing mouse hindbrain, which provides many of the extrinsic signals for inner ear formation, conditional knockout embryos of both sexes show that the inner ear source of Lmx1a is the major contributor of ear patterning...
May 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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